Search to RefSeq (Human) database
Query= 20030531C-001071 (20030531C-001071) 20030531C-001071
(1041 letters)
Database: RefSeq (Homo Sapiens/Amino Acid)
19,244 sequences; 10,046,356 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
Alignment gi|16117781|ref|NP_361014.1| (NM_033632) F-box protein FBW7 iso... 112 3e-25
Alignment gi|16117779|ref|NP_060785.2| (NM_018315) F-box protein FBW7 iso... 112 3e-25
Alignment gi|21071067|ref|NP_008882.2| (NM_006951) TBP-associated factor ... 109 4e-24
Alignment gi|16554629|ref|NP_438172.1| (NM_052821) WD repeat domain 5 pro... 100 2e-21
Alignment gi|16554627|ref|NP_060058.1| (NM_017588) WD repeat domain 5 pro... 100 2e-21
Alignment gi|4557741|ref|NP_000421.1| (NM_000430) platelet-activating fac... 100 2e-21
Alignment gi|23199987|ref|NP_061942.2| (NM_019069) WD repeat domain 5B [H... 98 1e-20
Alignment gi|16306498|ref|NP_387449.1| (NM_033645) F-box and WD-40 domain... 97 2e-20
Alignment gi|16306496|ref|NP_387448.1| (NM_033644) F-box and WD-40 domain... 97 2e-20
Alignment gi|16306494|ref|NP_036432.1| (NM_012300) F-box and WD-40 domain... 97 2e-20
>gi|16117781|ref|NP_361014.1| (NM_033632) F-box protein FBW7 isoform
1; archipelago, Drosophila, homolog of; F-box protein
FBW7; F-box protein SEL-10; homolog of C elegans sel-10
[Homo sapiens]
Length = 707
Score = 112 bits (281), Expect = 3e-25
Identities = 63/194 (32%), Positives = 91/194 (46%)
Frame = +3
Query: 459 GQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLEDEAAFTCSADCTIRKWDVLT 638
G R+++GS+D T ++WS G+C L GH V Q+ D + S D T++ W+ T
Sbjct: 391 GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDNIIISGSTDRTLKVWNAET 450
Query: 639 GQCLQVFRGHTSIVNRILVTNNQLFSSSYDRTARAWSVDKGQVSREFRGHRNCVLTLAYS 818
G+C+ GHTS V + + ++ S S D T R W ++ GQ GH V + Y
Sbjct: 451 GECIHTLYGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYD 510
Query: 819 APWDLPGAPCVEEAVAGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGH 998
G +V+G+ D KVW + C TL+GHT V L D G
Sbjct: 511 ----------------GRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFD--GI 552
Query: 999 TAFTGSTDATIRAW 1040
+GS D +IR W
Sbjct: 553 HVVSGSLDTSIRVW 566
Score = 102 bits (253), Expect = 6e-22
Identities = 57/196 (29%), Positives = 90/196 (45%), Gaps = 3/196 (1%)
Frame = +3
Query: 462 QRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLEDEAAFTCSADCTIRKWDVLTG 641
+R+++GS D T R+W GQC +L GH + V Q + + + D ++ WD T
Sbjct: 472 KRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYDGRRVVSGAYDFMVKVWDPETE 531
Query: 642 QCLQVFRGHTSIVNRILVTNNQLFSSSYDRTARAWSVDKGQVSREFRGHRNCVLTLAYSA 821
CL +GHT+ V + + S S D + R W V+ G GH++ +
Sbjct: 532 TCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGM---- 587
Query: 822 PWDLPGAPCVEEAVAGGLLVTGSTDGTAKVWQVASGCCHQTLRG---HTGAVLCLVLDTP 992
+ +LV+G+ D T K+W + +G C QTL+G H AV CL +
Sbjct: 588 ------------ELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNK- 634
Query: 993 GHTAFTGSTDATIRAW 1040
+ T S D T++ W
Sbjct: 635 -NFVITSSDDGTVKLW 649
Score = 84.7 bits (208), Expect = 9e-17
Identities = 46/161 (28%), Positives = 77/161 (47%), Gaps = 3/161 (1%)
Frame = +3
Query: 456 DGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLEDEAAFTCSADCTIRKWDVL 635
DG+R+++G+ D ++W C LQGH + V Q + + S D +IR WDV
Sbjct: 510 DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVE 569
Query: 636 TGQCLQVFRGHTSIVNRILVTNNQLFSSSYDRTARAWSVDKGQVSREFRG---HRNCVLT 806
TG C+ GH S+ + + + +N L S + D T + W + GQ + +G H++ V
Sbjct: 570 TGNCIHTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTC 629
Query: 807 LAYSAPWDLPGAPCVEEAVAGGLLVTGSTDGTAKVWQVASG 929
L ++ ++T S DGT K+W + +G
Sbjct: 630 LQFNK----------------NFVITSSDDGTVKLWDLKTG 654
Score = 78.6 bits (192), Expect = 7e-15
Identities = 40/113 (35%), Positives = 61/113 (53%), Gaps = 3/113 (2%)
Frame = +3
Query: 444 SLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLEDEAAFTCSADCTIRK 623
SL DG +++GS D + R+W G C L GH+S + +L+D + +AD T++
Sbjct: 546 SLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDNILVSGNADSTVKI 605
Query: 624 WDVLTGQCLQVFRG---HTSIVNRILVTNNQLFSSSYDRTARAWSVDKGQVSR 773
WD+ TGQCLQ +G H S V + N + +SS D T + W + G+ R
Sbjct: 606 WDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIR 658
Score = 65.9 bits (159), Expect = 5e-11
Identities = 41/131 (31%), Positives = 59/131 (44%), Gaps = 1/131 (0%)
Frame = +3
Query: 651 QVFRGHTS-IVNRILVTNNQLFSSSYDRTARAWSVDKGQVSREFRGHRNCVLTLAYSAPW 827
+V +GH ++ + N++ S S D T + WS G+ R GH V W
Sbjct: 374 KVLKGHDDHVITCLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGV--------W 425
Query: 828 DLPGAPCVEEAVAGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAF 1007
+ ++++GSTD T KVW +G C TL GHT V C+ L
Sbjct: 426 --------SSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHE--KRVV 475
Query: 1008 TGSTDATIRAW 1040
+GS DAT+R W
Sbjct: 476 SGSRDATLRVW 486
>gi|16117779|ref|NP_060785.2| (NM_018315) F-box protein FBW7 isoform
2; archipelago, Drosophila, homolog of; F-box protein
FBW7; F-box protein SEL-10; homolog of C elegans sel-10
[Homo sapiens]
Length = 627
Score = 112 bits (281), Expect = 3e-25
Identities = 63/194 (32%), Positives = 91/194 (46%)
Frame = +3
Query: 459 GQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLEDEAAFTCSADCTIRKWDVLT 638
G R+++GS+D T ++WS G+C L GH V Q+ D + S D T++ W+ T
Sbjct: 311 GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDNIIISGSTDRTLKVWNAET 370
Query: 639 GQCLQVFRGHTSIVNRILVTNNQLFSSSYDRTARAWSVDKGQVSREFRGHRNCVLTLAYS 818
G+C+ GHTS V + + ++ S S D T R W ++ GQ GH V + Y
Sbjct: 371 GECIHTLYGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYD 430
Query: 819 APWDLPGAPCVEEAVAGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGH 998
G +V+G+ D KVW + C TL+GHT V L D G
Sbjct: 431 ----------------GRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFD--GI 472
Query: 999 TAFTGSTDATIRAW 1040
+GS D +IR W
Sbjct: 473 HVVSGSLDTSIRVW 486
Score = 102 bits (253), Expect = 6e-22
Identities = 57/196 (29%), Positives = 90/196 (45%), Gaps = 3/196 (1%)
Frame = +3
Query: 462 QRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLEDEAAFTCSADCTIRKWDVLTG 641
+R+++GS D T R+W GQC +L GH + V Q + + + D ++ WD T
Sbjct: 392 KRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYDGRRVVSGAYDFMVKVWDPETE 451
Query: 642 QCLQVFRGHTSIVNRILVTNNQLFSSSYDRTARAWSVDKGQVSREFRGHRNCVLTLAYSA 821
CL +GHT+ V + + S S D + R W V+ G GH++ +
Sbjct: 452 TCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGM---- 507
Query: 822 PWDLPGAPCVEEAVAGGLLVTGSTDGTAKVWQVASGCCHQTLRG---HTGAVLCLVLDTP 992
+ +LV+G+ D T K+W + +G C QTL+G H AV CL +
Sbjct: 508 ------------ELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNK- 554
Query: 993 GHTAFTGSTDATIRAW 1040
+ T S D T++ W
Sbjct: 555 -NFVITSSDDGTVKLW 569
Score = 84.7 bits (208), Expect = 9e-17
Identities = 46/161 (28%), Positives = 77/161 (47%), Gaps = 3/161 (1%)
Frame = +3
Query: 456 DGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLEDEAAFTCSADCTIRKWDVL 635
DG+R+++G+ D ++W C LQGH + V Q + + S D +IR WDV
Sbjct: 430 DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVE 489
Query: 636 TGQCLQVFRGHTSIVNRILVTNNQLFSSSYDRTARAWSVDKGQVSREFRG---HRNCVLT 806
TG C+ GH S+ + + + +N L S + D T + W + GQ + +G H++ V
Sbjct: 490 TGNCIHTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTC 549
Query: 807 LAYSAPWDLPGAPCVEEAVAGGLLVTGSTDGTAKVWQVASG 929
L ++ ++T S DGT K+W + +G
Sbjct: 550 LQFNK----------------NFVITSSDDGTVKLWDLKTG 574
Score = 78.6 bits (192), Expect = 7e-15
Identities = 40/113 (35%), Positives = 61/113 (53%), Gaps = 3/113 (2%)
Frame = +3
Query: 444 SLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLEDEAAFTCSADCTIRK 623
SL DG +++GS D + R+W G C L GH+S + +L+D + +AD T++
Sbjct: 466 SLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDNILVSGNADSTVKI 525
Query: 624 WDVLTGQCLQVFRG---HTSIVNRILVTNNQLFSSSYDRTARAWSVDKGQVSR 773
WD+ TGQCLQ +G H S V + N + +SS D T + W + G+ R
Sbjct: 526 WDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIR 578
Score = 65.9 bits (159), Expect = 5e-11
Identities = 41/131 (31%), Positives = 59/131 (44%), Gaps = 1/131 (0%)
Frame = +3
Query: 651 QVFRGHTS-IVNRILVTNNQLFSSSYDRTARAWSVDKGQVSREFRGHRNCVLTLAYSAPW 827
+V +GH ++ + N++ S S D T + WS G+ R GH V W
Sbjct: 294 KVLKGHDDHVITCLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGV--------W 345
Query: 828 DLPGAPCVEEAVAGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAF 1007
+ ++++GSTD T KVW +G C TL GHT V C+ L
Sbjct: 346 --------SSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHE--KRVV 395
Query: 1008 TGSTDATIRAW 1040
+GS DAT+R W
Sbjct: 396 SGSRDATLRVW 406
>gi|21071067|ref|NP_008882.2| (NM_006951) TBP-associated factor 5
isoform 1; TATA box binding protein (TBP)-associated
factor 2D; TAF5 RNA polymerase II, TATA box binding
protein (TBP)-associated factor, 100 kD; TATA box binding
protein (TBP)-associated factor, RNA polymerase II, D,
100kD; transcription initiation factor TFIID 100 kD
subunit [Homo sapiens]
Length = 800
Score = 109 bits (272), Expect = 4e-24
Identities = 73/219 (33%), Positives = 95/219 (43%), Gaps = 4/219 (1%)
Frame = +3
Query: 396 SALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQL 575
S L++ H G + S SPD LL+ SEDGT RLWS C +GH V Q
Sbjct: 534 SELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQF 593
Query: 576 EDEAAFTCSA--DCTIRKWDVLTGQCLQVFRGHTSIVN--RILVTNNQLFSSSYDRTARA 743
+ S D R W Q L++F GH + VN R +N + + S DRT R
Sbjct: 594 SPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRL 653
Query: 744 WSVDKGQVSREFRGHRNCVLTLAYSAPWDLPGAPCVEEAVAGGLLVTGSTDGTAKVWQVA 923
W V G R F GH+ + +L +S G L TG+TDG +W +
Sbjct: 654 WDVLNGNCVRIFTGHKGPIHSLTFSPN--------------GRFLATGATDGRVLLWDIG 699
Query: 924 SGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAW 1040
G L+GHT V L G +GS D T+R W
Sbjct: 700 HGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLW 738
>gi|16554629|ref|NP_438172.1| (NM_052821) WD repeat domain 5 protein;
WD-repeat protein 5; likely ortholog of mouse WD repeat
protein BIG-3 (BMP-2-induced gene 3 kb) [Homo sapiens]
Length = 334
Score = 100 bits (249), Expect = 2e-21
Identities = 62/219 (28%), Positives = 101/219 (45%), Gaps = 7/219 (3%)
Frame = +3
Query: 405 RVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLEDE 584
+ + H+ GI+ ++ S D L++ S+D T ++W + G+C L+GH +YV C +
Sbjct: 81 KTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQ 140
Query: 585 AAFTCSA--DCTIRKWDVLTGQCLQVFRGHTSIVNRILVT--NNQLFSSSYDRTARAWSV 752
+ S D ++R WDV TG+CL+ H+ V+ + + + SSSYD R W
Sbjct: 141 SNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDT 200
Query: 753 DKGQVSREFRGHRNCVLTLAYSAPWDLPGAPCVEEAVAGGLLVTGSTDGTAKVWQVASGC 932
GQ C+ TL D P V+ + G ++ + D T K+W + G
Sbjct: 201 ASGQ----------CLKTLIDD---DNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGK 247
Query: 933 CHQTLRGHTGAVLCLVLD---TPGHTAFTGSTDATIRAW 1040
C +T GH C+ + T G +GS D + W
Sbjct: 248 CLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIW 286
Score = 88.2 bits (217), Expect = 9e-18
Identities = 55/214 (25%), Positives = 98/214 (45%), Gaps = 5/214 (2%)
Frame = +3
Query: 414 ADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLEDEAAF 593
A H ++ + SP+G+ L + S D ++W DG+ + GH+ ++ ++
Sbjct: 42 AGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNL 101
Query: 594 TCSA--DCTIRKWDVLTGQCLQVFRGHTSIV--NRILVTNNQLFSSSYDRTARAWSVDKG 761
SA D T++ WDV +G+CL+ +GH++ V +N + S S+D + R W V G
Sbjct: 102 LVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTG 161
Query: 762 QVSREFRGHRNCVLTLAYSAPWDLPGAPCVEEAVAGGLLVTGSTDGTAKVWQVASGCCHQ 941
+ + H + V + ++ G L+V+ S DG ++W ASG C +
Sbjct: 162 KCLKTLPAHSDPVSAVHFNRD--------------GSLIVSSSYDGLCRIWDTASGQCLK 207
Query: 942 TLRGHTGAVLCLVLDTP-GHTAFTGSTDATIRAW 1040
TL + V +P G + D T++ W
Sbjct: 208 TLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLW 241
Score = 69.7 bits (169), Expect = 3e-12
Identities = 51/224 (22%), Positives = 91/224 (39%), Gaps = 11/224 (4%)
Frame = +3
Query: 402 LRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLED 581
L+ H + + +P +++GS D + R+W G+C L H V+
Sbjct: 122 LKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNR 181
Query: 582 EAAFTCSA--DCTIRKWDVLTGQCLQVF----RGHTSIVNRILVTNNQLFSSSYDRTARA 743
+ + S+ D R WD +GQCL+ S V + + +++ D T +
Sbjct: 182 DGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFV-KFSPNGKYILAATLDNTLKL 240
Query: 744 WSVDKGQVSREFRGHRN---CVLTLAYSAPWDLPGAPCVEEAVAGGLLVTGSTDGTAKVW 914
W KG+ + + GH+N C+ A + + G G +V+GS D +W
Sbjct: 241 WDYSKGKCLKTYTGHKNEKYCIF-----ANFSVTG---------GKWIVSGSEDNLVYIW 286
Query: 915 QVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGS--TDATIRAW 1040
+ + Q L+GHT V+ + + + D TI+ W
Sbjct: 287 NLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330
Score = 66.6 bits (161), Expect = 3e-11
Identities = 43/180 (23%), Positives = 78/180 (42%), Gaps = 8/180 (4%)
Frame = +3
Query: 402 LRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCC-ALLQGHESYVTFCQLE 578
L+ H ++ + + DG +++ S DG R+W TA GQC L+ V+F +
Sbjct: 164 LKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFS 223
Query: 579 DEAAFTCSA--DCTIRKWDVLTGQCLQVFRGHTS-----IVNRILVTNNQLFSSSYDRTA 737
+ +A D T++ WD G+CL+ + GH + N + + S S D
Sbjct: 224 PNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLV 283
Query: 738 RAWSVDKGQVSREFRGHRNCVLTLAYSAPWDLPGAPCVEEAVAGGLLVTGSTDGTAKVWQ 917
W++ ++ ++ +GH + V++ A E +A L D T K+W+
Sbjct: 284 YIWNLQTKEIVQKLQGHTDVVISTACHP---------TENIIASAAL---ENDKTIKLWK 331
>gi|16554627|ref|NP_060058.1| (NM_017588) WD repeat domain 5 protein;
WD-repeat protein 5; likely ortholog of mouse WD repeat
protein BIG-3 (BMP-2-induced gene 3 kb) [Homo sapiens]
Length = 334
Score = 100 bits (249), Expect = 2e-21
Identities = 62/219 (28%), Positives = 101/219 (45%), Gaps = 7/219 (3%)
Frame = +3
Query: 405 RVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLEDE 584
+ + H+ GI+ ++ S D L++ S+D T ++W + G+C L+GH +YV C +
Sbjct: 81 KTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQ 140
Query: 585 AAFTCSA--DCTIRKWDVLTGQCLQVFRGHTSIVNRILVT--NNQLFSSSYDRTARAWSV 752
+ S D ++R WDV TG+CL+ H+ V+ + + + SSSYD R W
Sbjct: 141 SNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDT 200
Query: 753 DKGQVSREFRGHRNCVLTLAYSAPWDLPGAPCVEEAVAGGLLVTGSTDGTAKVWQVASGC 932
GQ C+ TL D P V+ + G ++ + D T K+W + G
Sbjct: 201 ASGQ----------CLKTLIDD---DNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGK 247
Query: 933 CHQTLRGHTGAVLCLVLD---TPGHTAFTGSTDATIRAW 1040
C +T GH C+ + T G +GS D + W
Sbjct: 248 CLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIW 286
Score = 88.2 bits (217), Expect = 9e-18
Identities = 55/214 (25%), Positives = 98/214 (45%), Gaps = 5/214 (2%)
Frame = +3
Query: 414 ADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLEDEAAF 593
A H ++ + SP+G+ L + S D ++W DG+ + GH+ ++ ++
Sbjct: 42 AGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNL 101
Query: 594 TCSA--DCTIRKWDVLTGQCLQVFRGHTSIV--NRILVTNNQLFSSSYDRTARAWSVDKG 761
SA D T++ WDV +G+CL+ +GH++ V +N + S S+D + R W V G
Sbjct: 102 LVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTG 161
Query: 762 QVSREFRGHRNCVLTLAYSAPWDLPGAPCVEEAVAGGLLVTGSTDGTAKVWQVASGCCHQ 941
+ + H + V + ++ G L+V+ S DG ++W ASG C +
Sbjct: 162 KCLKTLPAHSDPVSAVHFNRD--------------GSLIVSSSYDGLCRIWDTASGQCLK 207
Query: 942 TLRGHTGAVLCLVLDTP-GHTAFTGSTDATIRAW 1040
TL + V +P G + D T++ W
Sbjct: 208 TLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLW 241
Score = 69.7 bits (169), Expect = 3e-12
Identities = 51/224 (22%), Positives = 91/224 (39%), Gaps = 11/224 (4%)
Frame = +3
Query: 402 LRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLED 581
L+ H + + +P +++GS D + R+W G+C L H V+
Sbjct: 122 LKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNR 181
Query: 582 EAAFTCSA--DCTIRKWDVLTGQCLQVF----RGHTSIVNRILVTNNQLFSSSYDRTARA 743
+ + S+ D R WD +GQCL+ S V + + +++ D T +
Sbjct: 182 DGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFV-KFSPNGKYILAATLDNTLKL 240
Query: 744 WSVDKGQVSREFRGHRN---CVLTLAYSAPWDLPGAPCVEEAVAGGLLVTGSTDGTAKVW 914
W KG+ + + GH+N C+ A + + G G +V+GS D +W
Sbjct: 241 WDYSKGKCLKTYTGHKNEKYCIF-----ANFSVTG---------GKWIVSGSEDNLVYIW 286
Query: 915 QVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGS--TDATIRAW 1040
+ + Q L+GHT V+ + + + D TI+ W
Sbjct: 287 NLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330
Score = 66.6 bits (161), Expect = 3e-11
Identities = 43/180 (23%), Positives = 78/180 (42%), Gaps = 8/180 (4%)
Frame = +3
Query: 402 LRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCC-ALLQGHESYVTFCQLE 578
L+ H ++ + + DG +++ S DG R+W TA GQC L+ V+F +
Sbjct: 164 LKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFS 223
Query: 579 DEAAFTCSA--DCTIRKWDVLTGQCLQVFRGHTS-----IVNRILVTNNQLFSSSYDRTA 737
+ +A D T++ WD G+CL+ + GH + N + + S S D
Sbjct: 224 PNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLV 283
Query: 738 RAWSVDKGQVSREFRGHRNCVLTLAYSAPWDLPGAPCVEEAVAGGLLVTGSTDGTAKVWQ 917
W++ ++ ++ +GH + V++ A E +A L D T K+W+
Sbjct: 284 YIWNLQTKEIVQKLQGHTDVVISTACHP---------TENIIASAAL---ENDKTIKLWK 331
>gi|4557741|ref|NP_000421.1| (NM_000430) platelet-activating factor
acetylhydrolase, isoform Ib, alpha subunit (45kD);
lissencephaly 1 protein; Platelet-activating factor
acetylhydrolase, isoform 1B, alpha subunit [Homo sapiens]
Length = 410
Score = 100 bits (248), Expect = 2e-21
Identities = 65/224 (29%), Positives = 103/224 (45%), Gaps = 12/224 (5%)
Frame = +3
Query: 405 RVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQL--E 578
R H + +S G+ L + S D T +LW +C + GH+ V+ +
Sbjct: 144 RTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPN 203
Query: 579 DEAAFTCSADCTIRKWDVLTGQCLQVFRGHTSIVNRILVTNNQ----LFSSSYDRTARAW 746
+ + S D TI+ W+V TG C++ F GH V +V NQ + S S D+T R W
Sbjct: 204 GDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVR--MVRPNQDGTLIASCSNDQTVRVW 261
Query: 747 SVDKGQVSREFRGHRNCVLTLA------YSAPWDLPGAPCVEEAVAGGLLVTGSTDGTAK 908
V + E R H + V ++ YS+ + G+ + G L++GS D T K
Sbjct: 262 VVATKECKAELREHEHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIK 321
Query: 909 VWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAW 1040
+W V++G C TL GH V ++ + G + + D T+R W
Sbjct: 322 MWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVW 365
Score = 82.8 bits (203), Expect = 4e-16
Identities = 56/237 (23%), Positives = 91/237 (37%), Gaps = 24/237 (10%)
Frame = +3
Query: 402 LRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLED 581
+R H ++ +++ P+G +++ S D T ++W G C GH +V +
Sbjct: 185 IRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQ 244
Query: 582 EAAF--TCSADCTIRKWDVLTGQCLQVFRGHTSIVNRIL------------VTNNQ---- 707
+ +CS D T+R W V T +C R H +V I T ++
Sbjct: 245 DGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSETKKS 304
Query: 708 ------LFSSSYDRTARAWSVDKGQVSREFRGHRNCVLTLAYSAPWDLPGAPCVEEAVAG 869
L S S D+T + W V G GH N V + + + G
Sbjct: 305 GKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHS--------------GG 350
Query: 870 GLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAW 1040
+++ + D T +VW + C +TL H V L TGS D T++ W
Sbjct: 351 KFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVW 407
Score = 70.1 bits (170), Expect = 2e-12
Identities = 52/192 (27%), Positives = 79/192 (41%), Gaps = 26/192 (13%)
Frame = +3
Query: 420 HRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLEDEAAFTC 599
HR + + + DG + + S D T R+W A +C A L+ HE V E++++
Sbjct: 233 HREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSS 292
Query: 600 ----------------------SADCTIRKWDVLTGQCLQVFRGHTSIVNRILVTNNQLF 713
S D TI+ WDV TG CL GH + V +L + F
Sbjct: 293 ISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKF 352
Query: 714 --SSSYDRTARAWSVDKGQVSREFRGHRNCVLTLAY--SAPWDLPGAPCVEEAVAGGLLV 881
S + D+T R W + + H + V +L + +AP+ +V
Sbjct: 353 ILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPY----------------VV 396
Query: 882 TGSTDGTAKVWQ 917
TGS D T KVW+
Sbjct: 397 TGSVDQTVKVWE 408
Score = 65.9 bits (159), Expect = 5e-11
Identities = 52/172 (30%), Positives = 73/172 (42%), Gaps = 4/172 (2%)
Frame = +3
Query: 537 LQGHESYVTFCQLEDEAAFTCSA--DCTIRKWDVLTGQCLQVFRGHTSIVNRILV--TNN 704
L GH S VT + SA D TI+ WD TG + +GHT V I +
Sbjct: 104 LSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGK 163
Query: 705 QLFSSSYDRTARAWSVDKGQVSREFRGHRNCVLTLAYSAPWDLPGAPCVEEAVAGGLLVT 884
L S S D T + W + R GH + V ++A +P G +V+
Sbjct: 164 LLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAI-----MPN---------GDHIVS 209
Query: 885 GSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAW 1040
S D T K+W+V +G C +T GH V + + G + S D T+R W
Sbjct: 210 ASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVW 261
>gi|23199987|ref|NP_061942.2| (NM_019069) WD repeat domain 5B [Homo
sapiens]
Length = 330
Score = 97.8 bits (242), Expect = 1e-20
Identities = 62/214 (28%), Positives = 97/214 (44%), Gaps = 7/214 (3%)
Frame = +3
Query: 420 HRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLEDEAAFTC 599
H I+ ++ S D RL++ S+D T +LW G+C L+GH +YV C +
Sbjct: 82 HNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLII 141
Query: 600 SA--DCTIRKWDVLTGQCLQVFRGHTSIVNRI--LVTNNQLFSSSYDRTARAWSVDKGQV 767
S D T++ W+V TG+CL+ H+ V+ + + + + S SYD R W GQ
Sbjct: 142 SGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQ- 200
Query: 768 SREFRGHRNCVLTLAYSAPWDLPGAPCVEEAVAGGLLVTGSTDGTAKVWQVASGCCHQTL 947
C+ TL D P V+ + G ++T + D T K+W + G C +T
Sbjct: 201 ---------CLKTLVDD---DNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTY 248
Query: 948 RGHTGAVLCLVLD---TPGHTAFTGSTDATIRAW 1040
GH C+ + T G +GS D + W
Sbjct: 249 TGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIW 282
Score = 92.4 bits (228), Expect = 5e-19
Identities = 57/212 (26%), Positives = 99/212 (45%), Gaps = 5/212 (2%)
Frame = +3
Query: 420 HRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLEDEAAFTC 599
H ++ + SP+G+ L + S D +W DG+ L GH ++ +++
Sbjct: 40 HTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSSRLV 99
Query: 600 SA--DCTIRKWDVLTGQCLQVFRGHTSIV--NRILVTNNQLFSSSYDRTARAWSVDKGQV 767
SA D T++ WDV +G+CL+ +GH++ V +N + S S+D T + W V G+
Sbjct: 100 SASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKC 159
Query: 768 SREFRGHRNCVLTLAYSAPWDLPGAPCVEEAVAGGLLVTGSTDGTAKVWQVASGCCHQTL 947
+ H + V + ++ +G L+V+GS DG ++W ASG C +TL
Sbjct: 160 LKTLSAHSDPVSAVHFNC--------------SGSLIVSGSYDGLCRIWDAASGQCLKTL 205
Query: 948 RGHTGAVLCLVLDTP-GHTAFTGSTDATIRAW 1040
+ V +P G T + D T++ W
Sbjct: 206 VDDDNPPVSFVKFSPNGKYILTATLDNTLKLW 237
Score = 70.1 bits (170), Expect = 2e-12
Identities = 45/172 (26%), Positives = 77/172 (44%), Gaps = 4/172 (2%)
Frame = +3
Query: 537 LQGHESYVTFCQLEDEAAF--TCSADCTIRKWDVLTGQCLQVFRGHTSIVNRILVTNN-- 704
L GH V+ + + + SAD I W G+ + GH ++ + +++
Sbjct: 37 LVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSS 96
Query: 705 QLFSSSYDRTARAWSVDKGQVSREFRGHRNCVLTLAYSAPWDLPGAPCVEEAVAGGLLVT 884
+L S+S D+T + W V G+ + +GH N V ++ P L+++
Sbjct: 97 RLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPP--------------SNLIIS 142
Query: 885 GSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAW 1040
GS D T K+W+V +G C +TL H+ V + + G +GS D R W
Sbjct: 143 GSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIW 194
Score = 67.8 bits (164), Expect = 1e-11
Identities = 50/224 (22%), Positives = 89/224 (39%), Gaps = 11/224 (4%)
Frame = +3
Query: 402 LRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLED 581
L+ H + + +P +++GS D T ++W G+C L H V+
Sbjct: 118 LKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNC 177
Query: 582 EAAFTCSA--DCTIRKWDVLTGQCLQVF----RGHTSIVNRILVTNNQLFSSSYDRTARA 743
+ S D R WD +GQCL+ S V + + +++ D T +
Sbjct: 178 SGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFV-KFSPNGKYILTATLDNTLKL 236
Query: 744 WSVDKGQVSREFRGHRN---CVLTLAYSAPWDLPGAPCVEEAVAGGLLVTGSTDGTAKVW 914
W +G+ + + GH+N C+ A + + G G +V+GS D +W
Sbjct: 237 WDYSRGRCLKTYTGHKNEKYCIF-----ANFSVTG---------GKWIVSGSEDNLVYIW 282
Query: 915 QVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGS--TDATIRAW 1040
+ + Q L+GHT V+ + + + D TI+ W
Sbjct: 283 NLQTKEIVQKLQGHTDVVISAACHPTENLIASAALENDKTIKLW 326
>gi|16306498|ref|NP_387449.1| (NM_033645) F-box and WD-40 domain
protein 1B isoform A; F-box protein Fbw1b;
beta-transducin repeat-containing protein 2 [Homo
sapiens]
Length = 508
Score = 97.1 bits (240), Expect = 2e-20
Identities = 61/216 (28%), Positives = 95/216 (43%), Gaps = 3/216 (1%)
Frame = +3
Query: 402 LRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLED 581
L+V H G + L L D + ++TGS D T R+W G+ L H V + +
Sbjct: 239 LKVLTGHTGSV--LCLQYDERVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFSN 296
Query: 582 EAAFTCSADCTIRKWDVLTGQCL---QVFRGHTSIVNRILVTNNQLFSSSYDRTARAWSV 752
TCS D +I WD+ + + +V GH + VN + + + S+S DRT + WS
Sbjct: 297 GLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWST 356
Query: 753 DKGQVSREFRGHRNCVLTLAYSAPWDLPGAPCVEEAVAGGLLVTGSTDGTAKVWQVASGC 932
+ R GH+ + L Y L+V+GS+D T ++W + G
Sbjct: 357 STCEFVRTLNGHKRGIACLQY----------------RDRLVVSGSSDNTIRLWDIECGA 400
Query: 933 CHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAW 1040
C + L GH V C+ D +G+ D I+ W
Sbjct: 401 CLRVLEGHEELVRCIRFD--NKRIVSGAYDGKIKVW 434
Score = 74.3 bits (181), Expect = 1e-13
Identities = 37/116 (31%), Positives = 59/116 (49%)
Frame = +3
Query: 405 RVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLEDE 584
RV HR +N + D + +++ S D T ++WST+ + L GH+ + Q D
Sbjct: 323 RVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRDR 380
Query: 585 AAFTCSADCTIRKWDVLTGQCLQVFRGHTSIVNRILVTNNQLFSSSYDRTARAWSV 752
+ S+D TIR WD+ G CL+V GH +V I N ++ S +YD + W +
Sbjct: 381 LVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDL 436
Score = 67.0 bits (162), Expect = 2e-11
Identities = 52/203 (25%), Positives = 80/203 (38%), Gaps = 12/203 (5%)
Frame = +3
Query: 468 LLTGSEDGTARLWSTADGQCCAL---LQGHESYVTFCQLEDEAAFTCSADCTIRKWDVLT 638
++T S+D + +W A L L GH + V +D+ + S D TI+ W T
Sbjct: 299 MVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWSTST 358
Query: 639 GQCLQVFRGHTSIVNRILVTNNQLFSSSYDRTARAWSVDKGQVSREFRGHRNCVLTLAYS 818
+ ++ GH + + + + S S D T R W ++ G R GH V + +
Sbjct: 359 CEFVRTLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFD 418
Query: 819 APWDLPGAPCVEEAVAGGLLVTGSTDGTAKVWQV---------ASGCCHQTLRGHTGAVL 971
+V+G+ DG KVW + AS C +TL H+G V
Sbjct: 419 ----------------NKRIVSGAYDGKIKVWDLQAALDPRAPASTLCLRTLVEHSGRVF 462
Query: 972 CLVLDTPGHTAFTGSTDATIRAW 1040
L D + S D TI W
Sbjct: 463 RLQFDE--FQIISSSHDDTILIW 483
>gi|16306496|ref|NP_387448.1| (NM_033644) F-box and WD-40 domain
protein 1B isoform B; F-box protein Fbw1b;
beta-transducin repeat-containing protein 2 [Homo
sapiens]
Length = 529
Score = 97.1 bits (240), Expect = 2e-20
Identities = 61/216 (28%), Positives = 95/216 (43%), Gaps = 3/216 (1%)
Frame = +3
Query: 402 LRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLED 581
L+V H G + L L D + ++TGS D T R+W G+ L H V + +
Sbjct: 260 LKVLTGHTGSV--LCLQYDERVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFSN 317
Query: 582 EAAFTCSADCTIRKWDVLTGQCL---QVFRGHTSIVNRILVTNNQLFSSSYDRTARAWSV 752
TCS D +I WD+ + + +V GH + VN + + + S+S DRT + WS
Sbjct: 318 GLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWST 377
Query: 753 DKGQVSREFRGHRNCVLTLAYSAPWDLPGAPCVEEAVAGGLLVTGSTDGTAKVWQVASGC 932
+ R GH+ + L Y L+V+GS+D T ++W + G
Sbjct: 378 STCEFVRTLNGHKRGIACLQY----------------RDRLVVSGSSDNTIRLWDIECGA 421
Query: 933 CHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAW 1040
C + L GH V C+ D +G+ D I+ W
Sbjct: 422 CLRVLEGHEELVRCIRFD--NKRIVSGAYDGKIKVW 455
Score = 74.3 bits (181), Expect = 1e-13
Identities = 37/116 (31%), Positives = 59/116 (49%)
Frame = +3
Query: 405 RVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLEDE 584
RV HR +N + D + +++ S D T ++WST+ + L GH+ + Q D
Sbjct: 344 RVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRDR 401
Query: 585 AAFTCSADCTIRKWDVLTGQCLQVFRGHTSIVNRILVTNNQLFSSSYDRTARAWSV 752
+ S+D TIR WD+ G CL+V GH +V I N ++ S +YD + W +
Sbjct: 402 LVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDL 457
Score = 67.0 bits (162), Expect = 2e-11
Identities = 52/203 (25%), Positives = 80/203 (38%), Gaps = 12/203 (5%)
Frame = +3
Query: 468 LLTGSEDGTARLWSTADGQCCAL---LQGHESYVTFCQLEDEAAFTCSADCTIRKWDVLT 638
++T S+D + +W A L L GH + V +D+ + S D TI+ W T
Sbjct: 320 MVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWSTST 379
Query: 639 GQCLQVFRGHTSIVNRILVTNNQLFSSSYDRTARAWSVDKGQVSREFRGHRNCVLTLAYS 818
+ ++ GH + + + + S S D T R W ++ G R GH V + +
Sbjct: 380 CEFVRTLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFD 439
Query: 819 APWDLPGAPCVEEAVAGGLLVTGSTDGTAKVWQV---------ASGCCHQTLRGHTGAVL 971
+V+G+ DG KVW + AS C +TL H+G V
Sbjct: 440 ----------------NKRIVSGAYDGKIKVWDLQAALDPRAPASTLCLRTLVEHSGRVF 483
Query: 972 CLVLDTPGHTAFTGSTDATIRAW 1040
L D + S D TI W
Sbjct: 484 RLQFDE--FQIISSSHDDTILIW 504
>gi|16306494|ref|NP_036432.1| (NM_012300) F-box and WD-40 domain
protein 1B isoform C; F-box protein Fbw1b;
beta-transducin repeat-containing protein 2 [Homo
sapiens]
Length = 542
Score = 97.1 bits (240), Expect = 2e-20
Identities = 61/216 (28%), Positives = 95/216 (43%), Gaps = 3/216 (1%)
Frame = +3
Query: 402 LRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLED 581
L+V H G + L L D + ++TGS D T R+W G+ L H V + +
Sbjct: 273 LKVLTGHTGSV--LCLQYDERVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFSN 330
Query: 582 EAAFTCSADCTIRKWDVLTGQCL---QVFRGHTSIVNRILVTNNQLFSSSYDRTARAWSV 752
TCS D +I WD+ + + +V GH + VN + + + S+S DRT + WS
Sbjct: 331 GLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWST 390
Query: 753 DKGQVSREFRGHRNCVLTLAYSAPWDLPGAPCVEEAVAGGLLVTGSTDGTAKVWQVASGC 932
+ R GH+ + L Y L+V+GS+D T ++W + G
Sbjct: 391 STCEFVRTLNGHKRGIACLQY----------------RDRLVVSGSSDNTIRLWDIECGA 434
Query: 933 CHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAW 1040
C + L GH V C+ D +G+ D I+ W
Sbjct: 435 CLRVLEGHEELVRCIRFD--NKRIVSGAYDGKIKVW 468
Score = 74.3 bits (181), Expect = 1e-13
Identities = 37/116 (31%), Positives = 59/116 (49%)
Frame = +3
Query: 405 RVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLEDE 584
RV HR +N + D + +++ S D T ++WST+ + L GH+ + Q D
Sbjct: 357 RVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRDR 414
Query: 585 AAFTCSADCTIRKWDVLTGQCLQVFRGHTSIVNRILVTNNQLFSSSYDRTARAWSV 752
+ S+D TIR WD+ G CL+V GH +V I N ++ S +YD + W +
Sbjct: 415 LVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDL 470
Score = 67.0 bits (162), Expect = 2e-11
Identities = 52/203 (25%), Positives = 80/203 (38%), Gaps = 12/203 (5%)
Frame = +3
Query: 468 LLTGSEDGTARLWSTADGQCCAL---LQGHESYVTFCQLEDEAAFTCSADCTIRKWDVLT 638
++T S+D + +W A L L GH + V +D+ + S D TI+ W T
Sbjct: 333 MVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWSTST 392
Query: 639 GQCLQVFRGHTSIVNRILVTNNQLFSSSYDRTARAWSVDKGQVSREFRGHRNCVLTLAYS 818
+ ++ GH + + + + S S D T R W ++ G R GH V + +
Sbjct: 393 CEFVRTLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFD 452
Query: 819 APWDLPGAPCVEEAVAGGLLVTGSTDGTAKVWQV---------ASGCCHQTLRGHTGAVL 971
+V+G+ DG KVW + AS C +TL H+G V
Sbjct: 453 ----------------NKRIVSGAYDGKIKVWDLQAALDPRAPASTLCLRTLVEHSGRVF 496
Query: 972 CLVLDTPGHTAFTGSTDATIRAW 1040
L D + S D TI W
Sbjct: 497 RLQFDE--FQIISSSHDDTILIW 517
Database: RefSeq (Homo Sapiens/Amino Acid)
Posted date: Jul 1, 2003 6:07 AM
Number of letters in database: 10,046,356
Number of sequences in database: 19,244
Lambda K H
0.318 0.135 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24264286
Number of Sequences: 19244
Number of extensions: 710234
Number of successful extensions: 5693
Number of sequences better than 10.0: 235
Number of HSP's better than 10.0 without gapping: 2479
Number of HSP's successfully gapped in prelim test: 112
Number of HSP's that attempted gapping in prelim test: 542
Number of HSP's gapped (non-prelim): 4491
length of query: 347
length of database: 10,046,356
effective HSP length: 47
effective length of query: 299
effective length of database: 9,141,888
effective search space: 2733424512
effective search space used: 2733424512
frameshift window, decay const: 50, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 61 (28.1 bits)
Search to RefSeq (Mouse) database
Query= 20030531C-001071 (20030531C-001071) 20030531C-001071
(1041 letters)
Database: RefSeq (Mus Musculus/Amino Acid)
15,330 sequences; 7,155,815 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
Alignment gi|21218434|ref|NP_536353.2| (NM_080428) F-box and WD-40 domain... 112 2e-25
Alignment gi|28893469|ref|NP_796316.1| (NM_177342) RIKEN cDNA 6330528C20 ... 109 3e-24
Alignment gi|18252790|ref|NP_543124.1| (NM_080848) WD repeat domain 5; Bm... 100 1e-21
Alignment gi|7305363|ref|NP_038653.1| (NM_013625) platelet-activating fac... 100 2e-21
Alignment gi|23956270|ref|NP_598776.1| (NM_134015) F-box and WD-40 domain... 97 1e-20
Alignment gi|21312318|ref|NP_081389.1| (NM_027113) WD repeat domain 5B [M... 95 6e-20
Alignment gi|6753210|ref|NP_033901.1| (NM_009771) beta-transducin repeat ... 93 2e-19
Alignment gi|31980791|ref|NP_058064.2| (NM_016784) pleiotropic regulator ... 89 3e-18
Alignment gi|29789080|ref|NP_056642.1| (NM_015827) coatomer protein compl... 87 1e-17
Alignment gi|19527184|ref|NP_598727.1| (NM_133966) TAF5-like RNA polymera... 86 4e-17
>gi|21218434|ref|NP_536353.2| (NM_080428) F-box and WD-40 domain
protein 7, archipelago homolog; f-box only protein 30;
F-box-WD40 repeat protein 6 [Mus musculus]
Length = 629
Score = 112 bits (281), Expect = 2e-25
Identities = 63/194 (32%), Positives = 91/194 (46%)
Frame = +3
Query: 459 GQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLEDEAAFTCSADCTIRKWDVLT 638
G R+++GS+D T ++WS G+C L GH V Q+ D + S D T++ W+ T
Sbjct: 313 GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDNIIISGSTDRTLKVWNAET 372
Query: 639 GQCLQVFRGHTSIVNRILVTNNQLFSSSYDRTARAWSVDKGQVSREFRGHRNCVLTLAYS 818
G+C+ GHTS V + + ++ S S D T R W ++ GQ GH V + Y
Sbjct: 373 GECIHTLYGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYD 432
Query: 819 APWDLPGAPCVEEAVAGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGH 998
G +V+G+ D KVW + C TL+GHT V L D G
Sbjct: 433 ----------------GRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFD--GI 474
Query: 999 TAFTGSTDATIRAW 1040
+GS D +IR W
Sbjct: 475 HVVSGSLDTSIRVW 488
Score = 102 bits (253), Expect = 4e-22
Identities = 57/196 (29%), Positives = 90/196 (45%), Gaps = 3/196 (1%)
Frame = +3
Query: 462 QRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLEDEAAFTCSADCTIRKWDVLTG 641
+R+++GS D T R+W GQC +L GH + V Q + + + D ++ WD T
Sbjct: 394 KRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYDGRRVVSGAYDFMVKVWDPETE 453
Query: 642 QCLQVFRGHTSIVNRILVTNNQLFSSSYDRTARAWSVDKGQVSREFRGHRNCVLTLAYSA 821
CL +GHT+ V + + S S D + R W V+ G GH++ +
Sbjct: 454 TCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGM---- 509
Query: 822 PWDLPGAPCVEEAVAGGLLVTGSTDGTAKVWQVASGCCHQTLRG---HTGAVLCLVLDTP 992
+ +LV+G+ D T K+W + +G C QTL+G H AV CL +
Sbjct: 510 ------------ELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPSKHQSAVTCLQFNK- 556
Query: 993 GHTAFTGSTDATIRAW 1040
+ T S D T++ W
Sbjct: 557 -NFVITSSDDGTVKLW 571
Score = 84.7 bits (208), Expect = 7e-17
Identities = 46/161 (28%), Positives = 77/161 (47%), Gaps = 3/161 (1%)
Frame = +3
Query: 456 DGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLEDEAAFTCSADCTIRKWDVL 635
DG+R+++G+ D ++W C LQGH + V Q + + S D +IR WDV
Sbjct: 432 DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVE 491
Query: 636 TGQCLQVFRGHTSIVNRILVTNNQLFSSSYDRTARAWSVDKGQVSREFRG---HRNCVLT 806
TG C+ GH S+ + + + +N L S + D T + W + GQ + +G H++ V
Sbjct: 492 TGNCIHTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPSKHQSAVTC 551
Query: 807 LAYSAPWDLPGAPCVEEAVAGGLLVTGSTDGTAKVWQVASG 929
L ++ ++T S DGT K+W + +G
Sbjct: 552 LQFNK----------------NFVITSSDDGTVKLWDLKTG 576
Score = 78.6 bits (192), Expect = 5e-15
Identities = 40/113 (35%), Positives = 61/113 (53%), Gaps = 3/113 (2%)
Frame = +3
Query: 444 SLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLEDEAAFTCSADCTIRK 623
SL DG +++GS D + R+W G C L GH+S + +L+D + +AD T++
Sbjct: 468 SLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDNILVSGNADSTVKI 527
Query: 624 WDVLTGQCLQVFRG---HTSIVNRILVTNNQLFSSSYDRTARAWSVDKGQVSR 773
WD+ TGQCLQ +G H S V + N + +SS D T + W + G+ R
Sbjct: 528 WDIKTGQCLQTLQGPSKHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIR 580
Score = 65.9 bits (159), Expect = 3e-11
Identities = 41/131 (31%), Positives = 59/131 (44%), Gaps = 1/131 (0%)
Frame = +3
Query: 651 QVFRGHTS-IVNRILVTNNQLFSSSYDRTARAWSVDKGQVSREFRGHRNCVLTLAYSAPW 827
+V +GH ++ + N++ S S D T + WS G+ R GH V W
Sbjct: 296 KVLKGHDDHVITCLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGV--------W 347
Query: 828 DLPGAPCVEEAVAGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAF 1007
+ ++++GSTD T KVW +G C TL GHT V C+ L
Sbjct: 348 --------SSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHE--KRVV 397
Query: 1008 TGSTDATIRAW 1040
+GS DAT+R W
Sbjct: 398 SGSRDATLRVW 408
>gi|28893469|ref|NP_796316.1| (NM_177342) RIKEN cDNA 6330528C20 gene
[Mus musculus]
Length = 801
Score = 109 bits (272), Expect = 3e-24
Identities = 73/219 (33%), Positives = 95/219 (43%), Gaps = 4/219 (1%)
Frame = +3
Query: 396 SALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQL 575
S L++ H G + S SPD LL+ SEDGT RLWS C +GH V Q
Sbjct: 535 SELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQF 594
Query: 576 EDEAAFTCSA--DCTIRKWDVLTGQCLQVFRGHTSIVN--RILVTNNQLFSSSYDRTARA 743
+ S D R W Q L++F GH + VN R +N + + S DRT R
Sbjct: 595 SPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRL 654
Query: 744 WSVDKGQVSREFRGHRNCVLTLAYSAPWDLPGAPCVEEAVAGGLLVTGSTDGTAKVWQVA 923
W V G R F GH+ + +L +S G L TG+TDG +W +
Sbjct: 655 WDVLNGNCVRIFTGHKGPIHSLTFSPN--------------GRFLATGATDGRVLLWDIG 700
Query: 924 SGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAW 1040
G L+GHT V L G +GS D T+R W
Sbjct: 701 HGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLW 739
>gi|18252790|ref|NP_543124.1| (NM_080848) WD repeat domain 5;
Bmp2-induced gene [Mus musculus]
Length = 334
Score = 100 bits (249), Expect = 1e-21
Identities = 62/219 (28%), Positives = 101/219 (45%), Gaps = 7/219 (3%)
Frame = +3
Query: 405 RVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLEDE 584
+ + H+ GI+ ++ S D L++ S+D T ++W + G+C L+GH +YV C +
Sbjct: 81 KTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQ 140
Query: 585 AAFTCSA--DCTIRKWDVLTGQCLQVFRGHTSIVNRILVT--NNQLFSSSYDRTARAWSV 752
+ S D ++R WDV TG+CL+ H+ V+ + + + SSSYD R W
Sbjct: 141 SNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDT 200
Query: 753 DKGQVSREFRGHRNCVLTLAYSAPWDLPGAPCVEEAVAGGLLVTGSTDGTAKVWQVASGC 932
GQ C+ TL D P V+ + G ++ + D T K+W + G
Sbjct: 201 ASGQ----------CLKTLIDD---DNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGK 247
Query: 933 CHQTLRGHTGAVLCLVLD---TPGHTAFTGSTDATIRAW 1040
C +T GH C+ + T G +GS D + W
Sbjct: 248 CLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIW 286
Score = 88.2 bits (217), Expect = 6e-18
Identities = 55/214 (25%), Positives = 98/214 (45%), Gaps = 5/214 (2%)
Frame = +3
Query: 414 ADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLEDEAAF 593
A H ++ + SP+G+ L + S D ++W DG+ + GH+ ++ ++
Sbjct: 42 AGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNL 101
Query: 594 TCSA--DCTIRKWDVLTGQCLQVFRGHTSIV--NRILVTNNQLFSSSYDRTARAWSVDKG 761
SA D T++ WDV +G+CL+ +GH++ V +N + S S+D + R W V G
Sbjct: 102 LVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTG 161
Query: 762 QVSREFRGHRNCVLTLAYSAPWDLPGAPCVEEAVAGGLLVTGSTDGTAKVWQVASGCCHQ 941
+ + H + V + ++ G L+V+ S DG ++W ASG C +
Sbjct: 162 KCLKTLPAHSDPVSAVHFNRD--------------GSLIVSSSYDGLCRIWDTASGQCLK 207
Query: 942 TLRGHTGAVLCLVLDTP-GHTAFTGSTDATIRAW 1040
TL + V +P G + D T++ W
Sbjct: 208 TLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLW 241
Score = 69.7 bits (169), Expect = 2e-12
Identities = 51/224 (22%), Positives = 91/224 (39%), Gaps = 11/224 (4%)
Frame = +3
Query: 402 LRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLED 581
L+ H + + +P +++GS D + R+W G+C L H V+
Sbjct: 122 LKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNR 181
Query: 582 EAAFTCSA--DCTIRKWDVLTGQCLQVF----RGHTSIVNRILVTNNQLFSSSYDRTARA 743
+ + S+ D R WD +GQCL+ S V + + +++ D T +
Sbjct: 182 DGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFV-KFSPNGKYILAATLDNTLKL 240
Query: 744 WSVDKGQVSREFRGHRN---CVLTLAYSAPWDLPGAPCVEEAVAGGLLVTGSTDGTAKVW 914
W KG+ + + GH+N C+ A + + G G +V+GS D +W
Sbjct: 241 WDYSKGKCLKTYTGHKNEKYCIF-----ANFSVTG---------GKWIVSGSEDNLVYIW 286
Query: 915 QVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGS--TDATIRAW 1040
+ + Q L+GHT V+ + + + D TI+ W
Sbjct: 287 NLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330
Score = 66.6 bits (161), Expect = 2e-11
Identities = 43/180 (23%), Positives = 78/180 (42%), Gaps = 8/180 (4%)
Frame = +3
Query: 402 LRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCC-ALLQGHESYVTFCQLE 578
L+ H ++ + + DG +++ S DG R+W TA GQC L+ V+F +
Sbjct: 164 LKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFS 223
Query: 579 DEAAFTCSA--DCTIRKWDVLTGQCLQVFRGHTS-----IVNRILVTNNQLFSSSYDRTA 737
+ +A D T++ WD G+CL+ + GH + N + + S S D
Sbjct: 224 PNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLV 283
Query: 738 RAWSVDKGQVSREFRGHRNCVLTLAYSAPWDLPGAPCVEEAVAGGLLVTGSTDGTAKVWQ 917
W++ ++ ++ +GH + V++ A E +A L D T K+W+
Sbjct: 284 YIWNLQTKEIVQKLQGHTDVVISTACHP---------TENIIASAAL---ENDKTIKLWK 331
>gi|7305363|ref|NP_038653.1| (NM_013625) platelet-activating factor
acetylhydrolase, isoform 1b, beta1 subunit;
lissencephaly-1 protein; platelet-activating factor
acetylhydrolase IB alpha subunit [Mus musculus]
Length = 410
Score = 100 bits (248), Expect = 2e-21
Identities = 65/224 (29%), Positives = 103/224 (45%), Gaps = 12/224 (5%)
Frame = +3
Query: 405 RVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQL--E 578
R H + +S G+ L + S D T +LW +C + GH+ V+ +
Sbjct: 144 RTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPN 203
Query: 579 DEAAFTCSADCTIRKWDVLTGQCLQVFRGHTSIVNRILVTNNQ----LFSSSYDRTARAW 746
+ + S D TI+ W+V TG C++ F GH V +V NQ + S S D+T R W
Sbjct: 204 GDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVR--MVRPNQDGTLIASCSNDQTVRVW 261
Query: 747 SVDKGQVSREFRGHRNCVLTLA------YSAPWDLPGAPCVEEAVAGGLLVTGSTDGTAK 908
V + E R H + V ++ YS+ + G+ + G L++GS D T K
Sbjct: 262 VVATKECKAELREHEHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIK 321
Query: 909 VWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAW 1040
+W V++G C TL GH V ++ + G + + D T+R W
Sbjct: 322 MWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVW 365
Score = 82.8 bits (203), Expect = 3e-16
Identities = 56/237 (23%), Positives = 91/237 (37%), Gaps = 24/237 (10%)
Frame = +3
Query: 402 LRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLED 581
+R H ++ +++ P+G +++ S D T ++W G C GH +V +
Sbjct: 185 IRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQ 244
Query: 582 EAAF--TCSADCTIRKWDVLTGQCLQVFRGHTSIVNRIL------------VTNNQ---- 707
+ +CS D T+R W V T +C R H +V I T ++
Sbjct: 245 DGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSETKKS 304
Query: 708 ------LFSSSYDRTARAWSVDKGQVSREFRGHRNCVLTLAYSAPWDLPGAPCVEEAVAG 869
L S S D+T + W V G GH N V + + + G
Sbjct: 305 GKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHS--------------GG 350
Query: 870 GLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAW 1040
+++ + D T +VW + C +TL H V L TGS D T++ W
Sbjct: 351 KFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVW 407
Score = 70.1 bits (170), Expect = 2e-12
Identities = 52/192 (27%), Positives = 79/192 (41%), Gaps = 26/192 (13%)
Frame = +3
Query: 420 HRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLEDEAAFTC 599
HR + + + DG + + S D T R+W A +C A L+ HE V E++++
Sbjct: 233 HREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSS 292
Query: 600 ----------------------SADCTIRKWDVLTGQCLQVFRGHTSIVNRILVTNNQLF 713
S D TI+ WDV TG CL GH + V +L + F
Sbjct: 293 ISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKF 352
Query: 714 --SSSYDRTARAWSVDKGQVSREFRGHRNCVLTLAY--SAPWDLPGAPCVEEAVAGGLLV 881
S + D+T R W + + H + V +L + +AP+ +V
Sbjct: 353 ILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPY----------------VV 396
Query: 882 TGSTDGTAKVWQ 917
TGS D T KVW+
Sbjct: 397 TGSVDQTVKVWE 408
Score = 65.9 bits (159), Expect = 3e-11
Identities = 52/172 (30%), Positives = 73/172 (42%), Gaps = 4/172 (2%)
Frame = +3
Query: 537 LQGHESYVTFCQLEDEAAFTCSA--DCTIRKWDVLTGQCLQVFRGHTSIVNRILV--TNN 704
L GH S VT + SA D TI+ WD TG + +GHT V I +
Sbjct: 104 LSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGK 163
Query: 705 QLFSSSYDRTARAWSVDKGQVSREFRGHRNCVLTLAYSAPWDLPGAPCVEEAVAGGLLVT 884
L S S D T + W + R GH + V ++A +P G +V+
Sbjct: 164 LLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAI-----MPN---------GDHIVS 209
Query: 885 GSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAW 1040
S D T K+W+V +G C +T GH V + + G + S D T+R W
Sbjct: 210 ASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVW 261
>gi|23956270|ref|NP_598776.1| (NM_134015) F-box and WD-40 domain
protein 1B [Mus musculus]
Length = 563
Score = 97.1 bits (240), Expect = 1e-20
Identities = 61/216 (28%), Positives = 95/216 (43%), Gaps = 3/216 (1%)
Frame = +3
Query: 402 LRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLED 581
L+V H G + L L D + ++TGS D T R+W G+ L H V + +
Sbjct: 294 LKVLTGHTGSV--LCLQYDERVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFSN 351
Query: 582 EAAFTCSADCTIRKWDVLTGQCL---QVFRGHTSIVNRILVTNNQLFSSSYDRTARAWSV 752
TCS D +I WD+ + + +V GH + VN + + + S+S DRT + WS
Sbjct: 352 GLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWST 411
Query: 753 DKGQVSREFRGHRNCVLTLAYSAPWDLPGAPCVEEAVAGGLLVTGSTDGTAKVWQVASGC 932
+ R GH+ + L Y L+V+GS+D T ++W + G
Sbjct: 412 STCEFVRTLNGHKRGIACLQY----------------RDRLVVSGSSDNTIRLWDIECGA 455
Query: 933 CHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAW 1040
C + L GH V C+ D +G+ D I+ W
Sbjct: 456 CLRVLEGHEELVRCIRFD--NKRIVSGAYDGKIKVW 489
Score = 74.3 bits (181), Expect = 9e-14
Identities = 37/116 (31%), Positives = 59/116 (49%)
Frame = +3
Query: 405 RVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLEDE 584
RV HR +N + D + +++ S D T ++WST+ + L GH+ + Q D
Sbjct: 378 RVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRDR 435
Query: 585 AAFTCSADCTIRKWDVLTGQCLQVFRGHTSIVNRILVTNNQLFSSSYDRTARAWSV 752
+ S+D TIR WD+ G CL+V GH +V I N ++ S +YD + W +
Sbjct: 436 LVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDL 491
Score = 67.0 bits (162), Expect = 1e-11
Identities = 52/203 (25%), Positives = 80/203 (38%), Gaps = 12/203 (5%)
Frame = +3
Query: 468 LLTGSEDGTARLWSTADGQCCAL---LQGHESYVTFCQLEDEAAFTCSADCTIRKWDVLT 638
++T S+D + +W A L L GH + V +D+ + S D TI+ W T
Sbjct: 354 MVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWSTST 413
Query: 639 GQCLQVFRGHTSIVNRILVTNNQLFSSSYDRTARAWSVDKGQVSREFRGHRNCVLTLAYS 818
+ ++ GH + + + + S S D T R W ++ G R GH V + +
Sbjct: 414 CEFVRTLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFD 473
Query: 819 APWDLPGAPCVEEAVAGGLLVTGSTDGTAKVWQV---------ASGCCHQTLRGHTGAVL 971
+V+G+ DG KVW + AS C +TL H+G V
Sbjct: 474 ----------------NKRIVSGAYDGKIKVWDLQAALDPRAPASTLCLRTLVEHSGRVF 517
Query: 972 CLVLDTPGHTAFTGSTDATIRAW 1040
L D + S D TI W
Sbjct: 518 RLQFDE--FQIISSSHDDTILIW 538
>gi|21312318|ref|NP_081389.1| (NM_027113) WD repeat domain 5B [Mus
musculus]
Length = 328
Score = 94.7 bits (234), Expect = 6e-20
Identities = 65/221 (29%), Positives = 104/221 (46%), Gaps = 7/221 (3%)
Frame = +3
Query: 399 ALRVC-ADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQL 575
ALR+ A H I+ + SP+G+ L + + D +W DG C L GH ++
Sbjct: 30 ALRLTLAGHSAAISSVKFSPNGEWLASSAADALIIIWGAYDGNCKKTLYGHSLEISDVAW 89
Query: 576 EDEAAFTCSA--DCTIRKWDVLTGQCLQVFRGHTSIV--NRILVTNNQLFSSSYDRTARA 743
+++ SA D T++ WD+ +G+CL+ +GH+ V +N + S S+D + +
Sbjct: 90 SSDSSRLVSASDDKTLKVWDMRSGKCLKTLKGHSDFVFCCDFNPPSNLIVSGSFDESVKI 149
Query: 744 WSVDKGQVSREFRGHRNCVLTL-AYSAPWDLPGAPCVEEAVAGGLLVTGSTDGTAKVWQV 920
W V G+ C+ TL A+S P C G L+V+GS DG ++W
Sbjct: 150 WEVKTGK----------CLKTLSAHSDPISAVNFNC-----NGSLIVSGSYDGLCRIWDA 194
Query: 921 ASGCCHQTLRGHTGAVLCLVLDTP-GHTAFTGSTDATIRAW 1040
ASG C +TL + V +P G T + D T++ W
Sbjct: 195 ASGQCLRTLADEGNPPVSFVKFSPNGKYILTATLDNTLKLW 235
Score = 89.7 bits (221), Expect = 2e-18
Identities = 59/214 (27%), Positives = 93/214 (42%), Gaps = 7/214 (3%)
Frame = +3
Query: 420 HRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLEDEAAFTC 599
H I+ ++ S D RL++ S+D T ++W G+C L+GH +V C +
Sbjct: 80 HSLEISDVAWSSDSSRLVSASDDKTLKVWDMRSGKCLKTLKGHSDFVFCCDFNPPSNLIV 139
Query: 600 SA--DCTIRKWDVLTGQCLQVFRGHTSIVNRILVTNN--QLFSSSYDRTARAWSVDKGQV 767
S D +++ W+V TG+CL+ H+ ++ + N + S SYD R W GQ
Sbjct: 140 SGSFDESVKIWEVKTGKCLKTLSAHSDPISAVNFNCNGSLIVSGSYDGLCRIWDAASGQ- 198
Query: 768 SREFRGHRNCVLTLAYSAPWDLPGAPCVEEAVAGGLLVTGSTDGTAKVWQVASGCCHQTL 947
C+ TLA P V+ + G ++T + D T K+W + G C +T
Sbjct: 199 ---------CLRTLADEGN---PPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTY 246
Query: 948 RGHTGAVLCLVLD---TPGHTAFTGSTDATIRAW 1040
GH CL T +GS D + W
Sbjct: 247 TGHKNEKYCLFASFSVTGRKWVVSGSEDNMVYIW 280
Score = 64.3 bits (155), Expect = 9e-11
Identities = 45/180 (25%), Positives = 83/180 (46%), Gaps = 9/180 (5%)
Frame = +3
Query: 402 LRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALL--QGHE--SYVTFC 569
L+ + H I+ ++ + +G +++GS DG R+W A GQC L +G+ S+V F
Sbjct: 158 LKTLSAHSDPISAVNFNCNGSLIVSGSYDGLCRIWDAASGQCLRTLADEGNPPVSFVKFS 217
Query: 570 QLEDEAAFTCSADCTIRKWDVLTGQCLQVFRGHTS----IVNRILVTNNQ-LFSSSYDRT 734
+ T + D T++ WD G+CL+ + GH + + VT + + S S D
Sbjct: 218 P-NGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCLFASFSVTGRKWVVSGSEDNM 276
Query: 735 ARAWSVDKGQVSREFRGHRNCVLTLAYSAPWDLPGAPCVEEAVAGGLLVTGSTDGTAKVW 914
W++ ++ + +GH + V++ A ++ + +E D T KVW
Sbjct: 277 VYIWNLQTKEIVQRLQGHTDVVISAACHPTKNIIASAALE------------NDKTIKVW 324
>gi|6753210|ref|NP_033901.1| (NM_009771) beta-transducin repeat
containing protein; SCF b-TRCP [Mus musculus]
Length = 569
Score = 92.8 bits (229), Expect = 2e-19
Identities = 59/215 (27%), Positives = 94/215 (43%), Gaps = 3/215 (1%)
Frame = +3
Query: 405 RVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLEDE 584
R+ H G + L L D + ++TGS D T R+W G+ L H V + +
Sbjct: 301 RILTGHTGSV--LCLQYDERVIITGSSDSTVRVWDVNAGEMLNTLIHHCEAVLHLRFNNG 358
Query: 585 AAFTCSADCTIRKWDVLTGQCL---QVFRGHTSIVNRILVTNNQLFSSSYDRTARAWSVD 755
TCS D +I WD+ + + +V GH + VN + + + S+S DRT + W+
Sbjct: 359 MMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWNTS 418
Query: 756 KGQVSREFRGHRNCVLTLAYSAPWDLPGAPCVEEAVAGGLLVTGSTDGTAKVWQVASGCC 935
+ R GH+ + L Y L+V+GS+D T ++W + G C
Sbjct: 419 TCEFVRTLNGHKRGIACLQY----------------RDRLVVSGSSDNTIRLWDIECGAC 462
Query: 936 HQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAW 1040
+ L GH V C+ D +G+ D I+ W
Sbjct: 463 LRVLEGHEELVRCIRFD--NKRIVSGAYDGKIKVW 495
Score = 73.2 bits (178), Expect = 2e-13
Identities = 36/116 (31%), Positives = 59/116 (50%)
Frame = +3
Query: 405 RVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLEDE 584
RV HR +N + D + +++ S D T ++W+T+ + L GH+ + Q D
Sbjct: 384 RVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQYRDR 441
Query: 585 AAFTCSADCTIRKWDVLTGQCLQVFRGHTSIVNRILVTNNQLFSSSYDRTARAWSV 752
+ S+D TIR WD+ G CL+V GH +V I N ++ S +YD + W +
Sbjct: 442 LVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDL 497
>gi|31980791|ref|NP_058064.2| (NM_016784) pleiotropic regulator 1 [Mus
musculus]
Length = 513
Score = 89.4 bits (220), Expect = 3e-18
Identities = 63/216 (29%), Positives = 96/216 (44%), Gaps = 4/216 (1%)
Frame = +3
Query: 405 RVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYV--TFCQLE 578
RV + H G + +++ P Q +TGS D T ++W A G+ L GH S V
Sbjct: 197 RVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTR 256
Query: 579 DEAAFTCSADCTIRKWDVLTGQCLQVFRGHTSIVNRILV--TNNQLFSSSYDRTARAWSV 752
F+C D ++ WD+ + ++ + GH S V + + T + L + S D TAR W V
Sbjct: 257 SPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTLDVLVTCSRDSTARIWDV 316
Query: 753 DKGQVSREFRGHRNCVLTLAYSAPWDLPGAPCVEEAVAGGLLVTGSTDGTAKVWQVASGC 932
GH N V T+ A A ++TGS D T ++W + +G
Sbjct: 317 RTKASVHTLSGHTNAVATVRCQA--------------AEPQIITGSHDTTIRLWDLVAGK 362
Query: 933 CHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAW 1040
TL H +V +VL +T +GS D I+ W
Sbjct: 363 TRVTLTNHKKSVRAVVLHPLLYTFASGSPD-NIKQW 397
Score = 67.4 bits (163), Expect = 1e-11
Identities = 59/220 (26%), Positives = 84/220 (37%), Gaps = 13/220 (5%)
Frame = +3
Query: 420 HRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTF--CQLEDEAAF 593
H + L L P L+T S D TAR+W L GH + V CQ +
Sbjct: 286 HLSAVYGLDLHPTLDVLVTCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQII 345
Query: 594 TCSADCTIRKWDVLTGQCLQVFRGHTSIVNRILVTNNQL--FSSSYDRTARAWSVDKGQV 767
T S D TIR WD++ G+ H V R +V + L F+S + W G
Sbjct: 346 TGSHDTTIRLWDLVAGKTRVTLTNHKKSV-RAVVLHPLLYTFASGSPDNIKQWKFPDGGF 404
Query: 768 SREFRGHRNCVLTLAYSAPWDLPGAPCVEEAVAGGLLVTGSTDGTAKVWQVASGCCHQ-- 941
+ GH + TLA +A G+LV+G+ +GT +W +G Q
Sbjct: 405 IQNLSGHNAIINTLAVNAD---------------GVLVSGADNGTMHLWDWRTGYNFQRV 449
Query: 942 -------TLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAW 1040
+L +G C D T D TI+ +
Sbjct: 450 HAAVQPGSLDSESGIFAC-AFDRSESRLLTAEADKTIKVY 488
Score = 43.1 bits (100), Expect = 2e-04
Identities = 28/119 (23%), Positives = 48/119 (39%), Gaps = 2/119 (1%)
Frame = +3
Query: 396 SALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQL 575
+++ + H + + +++TGS D T RLW G+ L H+ V L
Sbjct: 320 ASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLVAGKTRVTLTNHKKSVRAVVL 379
Query: 576 EDEA-AFTCSADCTIRKWDVLTGQCLQVFRGHTSIVNRILVTNNQLFSSSYDR-TARAW 746
F + I++W G +Q GH +I+N + V + + S D T W
Sbjct: 380 HPLLYTFASGSPDNIKQWKFPDGGFIQNLSGHNAIINTLAVNADGVLVSGADNGTMHLW 438
Score = 31.2 bits (69), Expect = 0.87
Identities = 12/35 (34%), Positives = 19/35 (54%)
Frame = +3
Query: 936 HQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAW 1040
++ + GH G V C+ ++ TGS D TI+ W
Sbjct: 196 YRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIW 230
>gi|29789080|ref|NP_056642.1| (NM_015827) coatomer protein complex,
subunit beta 2 (beta prime) [Mus musculus]
Length = 905
Score = 87.0 bits (214), Expect = 1e-17
Identities = 57/197 (28%), Positives = 85/197 (42%), Gaps = 6/197 (3%)
Frame = +3
Query: 468 LLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLEDEAAF--TCSADCTIRKWDV-LT 638
++TG++D R+++ + + + H Y+ + F T S D I+ WD
Sbjct: 72 VVTGADDMQIRVFNYNTLERVHMFEAHSDYIRCIAVHPTQPFILTSSDDMLIKLWDWDKK 131
Query: 639 GQCLQVFRGHTSIVNRILVT---NNQLFSSSYDRTARAWSVDKGQVSREFRGHRNCVLTL 809
C QVF GHT V +I++ NNQ S+S DRT + W + + GH V +
Sbjct: 132 WSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSPNFTLEGHEKGVNCI 191
Query: 810 AYSAPWDLPGAPCVEEAVAGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDT 989
Y + D P L++G+ D K+W + C QTL GH V C
Sbjct: 192 DYYSGGDKP------------YLISGADDRLVKIWDYQNKTCVQTLEGHAQNVSCASFHP 239
Query: 990 PGHTAFTGSTDATIRAW 1040
TGS D T+R W
Sbjct: 240 ELPIIITGSEDGTVRIW 256
Score = 37.0 bits (84), Expect = 0.016
Identities = 20/73 (27%), Positives = 33/73 (44%), Gaps = 4/73 (5%)
Frame = +3
Query: 420 HRGGINWLSLSPDGQR--LLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLEDE--A 587
H G+N + G + L++G++D ++W + C L+GH V+ E
Sbjct: 184 HEKGVNCIDYYSGGDKPYLISGADDRLVKIWDYQNKTCVQTLEGHAQNVSCASFHPELPI 243
Query: 588 AFTCSADCTIRKW 626
T S D T+R W
Sbjct: 244 IITGSEDGTVRIW 256
Score = 33.1 bits (74), Expect = 0.23
Identities = 29/124 (23%), Positives = 48/124 (38%), Gaps = 7/124 (5%)
Frame = +3
Query: 396 SALRVCADHRGGINWLSLSP-DGQRLLTGSEDGTARLWSTADGQCCALLQGHE---SYVT 563
S +V H + + ++P D + + S D T ++W L+GHE + +
Sbjct: 133 SCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSPNFTLEGHEKGVNCID 192
Query: 564 FCQLEDEAAFTCSADCTIRK-WDVLTGQCLQVFRGHTSIVNRILVTNNQ--LFSSSYDRT 734
+ D+ AD + K WD C+Q GH V+ + + S D T
Sbjct: 193 YYSGGDKPYLISGADDRLVKIWDYQNKTCVQTLEGHAQNVSCASFHPELPIIITGSEDGT 252
Query: 735 ARAW 746
R W
Sbjct: 253 VRIW 256
Score = 31.6 bits (70), Expect = 0.67
Identities = 12/32 (37%), Positives = 20/32 (62%)
Frame = +3
Query: 420 HRGGINWLSLSPDGQRLLTGSEDGTARLWSTA 515
H ++ S P+ ++TGSEDGT R+W ++
Sbjct: 228 HAQNVSCASFHPELPIIITGSEDGTVRIWHSS 259
>gi|19527184|ref|NP_598727.1| (NM_133966) TAF5-like RNA polymerase II,
p300/CBP-associated factor (PCAF)-associated factor [Mus
musculus]
Length = 589
Score = 85.5 bits (210), Expect = 4e-17
Identities = 60/217 (27%), Positives = 91/217 (41%), Gaps = 4/217 (1%)
Frame = +3
Query: 402 LRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLED 581
+++ H G + D LL+ SED + R W L QGH V +
Sbjct: 335 MKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPVWDVDISP 394
Query: 582 EAAFTCSA--DCTIRKWDVLTGQCLQVFRGHTSIVNRILV--TNNQLFSSSYDRTARAWS 749
+ + S D T R W L+++ GH + V+ + +N L + S D+T R WS
Sbjct: 395 FSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKTVRLWS 454
Query: 750 VDKGQVSREFRGHRNCVLTLAYSAPWDLPGAPCVEEAVAGGLLVTGSTDGTAKVWQVASG 929
+G R F GHR VL+L++S G L + D K+W +ASG
Sbjct: 455 AQQGNSVRLFTGHRGPVLSLSFSPN--------------GKYLASAGEDQRLKLWDLASG 500
Query: 930 CCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAW 1040
+ LRGHT ++ L + S D ++R W
Sbjct: 501 TLFKELRGHTDSITSLAFSPDSGLIASASMDNSVRVW 537
Score = 78.2 bits (191), Expect = 6e-15
Identities = 49/181 (27%), Positives = 82/181 (45%), Gaps = 4/181 (2%)
Frame = +3
Query: 441 LSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLEDEAAF--TCSADCT 614
+ +SP +GS D TARLWS + GH + V + + + T S D T
Sbjct: 390 VDISPFSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKT 449
Query: 615 IRKWDVLTGQCLQVFRGHTSIVNRILVTNN--QLFSSSYDRTARAWSVDKGQVSREFRGH 788
+R W G +++F GH V + + N L S+ D+ + W + G + +E RGH
Sbjct: 450 VRLWSAQQGNSVRLFTGHRGPVLSLSFSPNGKYLASAGEDQRLKLWDLASGTLFKELRGH 509
Query: 789 RNCVLTLAYSAPWDLPGAPCVEEAVAGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAV 968
+ + +LA+S GL+ + S D + +VW + S CC+ G +G +
Sbjct: 510 TDSITSLAFSPD--------------SGLIASASMDNSVRVWDIRSTCCNTPADGSSGEL 555
Query: 969 L 971
+
Sbjct: 556 V 556
Score = 65.5 bits (158), Expect = 4e-11
Identities = 40/155 (25%), Positives = 66/155 (41%), Gaps = 15/155 (9%)
Frame = +3
Query: 402 LRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLED 581
LR+ A H ++ + P+ L TGS D T RLWS G L GH V
Sbjct: 419 LRIYAGHLADVDCVKFHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLSFSP 478
Query: 582 EAAFTCSA--DCTIRKWDVLTGQCLQVFRGHTSIVNRILVT--NNQLFSSSYDRTARAWS 749
+ SA D ++ WD+ +G + RGHT + + + + + S+S D + R W
Sbjct: 479 NGKYLASAGEDQRLKLWDLASGTLFKELRGHTDSITSLAFSPDSGLIASASMDNSVRVWD 538
Query: 750 V-----------DKGQVSREFRGHRNCVLTLAYSA 821
+ G++ + G + VL++ + A
Sbjct: 539 IRSTCCNTPADGSSGELVGVYTGQMSNVLSVQFMA 573
Score = 52.0 bits (123), Expect = 5e-07
Identities = 27/86 (31%), Positives = 44/86 (50%), Gaps = 2/86 (2%)
Frame = +3
Query: 396 SALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQL 575
+++R+ HRG + LS SP+G+ L + ED +LW A G L+GH +T
Sbjct: 459 NSVRLFTGHRGPVLSLSFSPNGKYLASAGEDQRLKLWDLASGTLFKELRGHTDSITSLAF 518
Query: 576 EDEAAFTCSA--DCTIRKWDVLTGQC 647
++ SA D ++R WD+ + C
Sbjct: 519 SPDSGLIASASMDNSVRVWDIRSTCC 544
Database: RefSeq (Mus Musculus/Amino Acid)
Posted date: Jul 1, 2003 6:07 AM
Number of letters in database: 7,155,815
Number of sequences in database: 15,330
Lambda K H
0.318 0.135 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16835167
Number of Sequences: 15330
Number of extensions: 471362
Number of successful extensions: 3648
Number of sequences better than 10.0: 174
Number of HSP's better than 10.0 without gapping: 2008
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3092
length of query: 347
length of database: 7,155,815
effective HSP length: 47
effective length of query: 299
effective length of database: 6,435,305
effective search space: 1924156195
effective search space used: 1924156195
frameshift window, decay const: 50, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 60 (27.7 bits)