Search to RefSeq (Human) database
Query= 20030531S-017538 (20030531S-017538) 20030531S-017538
(791 letters)
Database: RefSeq (Homo Sapiens/Amino Acid)
19,244 sequences; 10,046,356 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
Alignment gi|27597085|ref|NP_000357.3| (NM_000366) tropomyosin 1 (alpha) ... 253 2e-68
Alignment gi|4507649|ref|NP_003280.1| (NM_003289) tropomyosin 2 (beta) [H... 252 7e-68
Alignment gi|4507651|ref|NP_003281.1| (NM_003290) tropomyosin 4 [Homo sap... 167 6e-45
Alignment gi|22748619|ref|NP_689476.1| (NM_152263) tropomyosin 3 [Homo sa... 155 4e-40
Alignment gi|24119203|ref|NP_705935.1| (NM_153649) tropomyosin 3 [Homo sa... 136 2e-34
Alignment gi|24431997|ref|NP_078857.2| (NM_024581) chromosome 6 open read... 50 1e-06
Alignment gi|21735548|ref|NP_009117.2| (NM_007186) centrosomal protein 2;... 49 4e-06
Alignment gi|6005904|ref|NP_009045.1| (NM_007114) TATA element modulatory... 49 5e-06
Alignment gi|7669506|ref|NP_005954.2| (NM_005963) myosin, heavy polypepti... 45 6e-05
Alignment gi|4503469|ref|NP_003557.1| (NM_003566) early endosome antigen ... 45 8e-05
>gi|27597085|ref|NP_000357.3| (NM_000366) tropomyosin 1 (alpha)
[Homo sapiens]
Length = 284
Score = 253 bits (645), Expect(2) = 2e-68
Identities = 137/203 (67%), Positives = 155/203 (75%)
Frame = +1
Query: 139 MEAIKKKMQMLKLDKENAIDRAEQAESDKKAAEEKCKQVEEELTHLQKKLKGTEDELDKY 318
M+AIKKKMQMLKLDKENA+DRAEQAE+DKKAAE++ KQ+E+EL LQKKLKGTEDELDKY
Sbjct: 1 MDAIKKKMQMLKLDKENALDRAEQAEADKKAAEDRSKQLEDELVSLQKKLKGTEDELDKY 60
Query: 319 SENLKDAQEKLELSEKKASDAEGDVAALNRRIQLVEEELDRAQERXXXXXXXXXXXXXXX 498
SE LKDAQEKLEL+EKKA+DAE DVA+LNRRIQLVEEELDRAQER
Sbjct: 61 SEALKDAQEKLELAEKKATDAEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAA 120
Query: 499 XXXXRGMKVIENRAMKDEEKMEIQEMQLXEAKHIAEEADRKYEEVARKLVIXXXXXXXXX 678
RGMKVIE+RA KDEEKMEIQE+QL EAKHIAE+ADRKYEEVARKLVI
Sbjct: 121 DESERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEEVARKLVIIESDLERAE 180
Query: 679 XXXXVSELKCGDL*EETQNVTNT 747
+SE + L E+ + + T
Sbjct: 181 ERAELSEGQVRQLEEQLRIMDQT 203
Score = 51.2 bits (121), Expect = 8e-07
Identities = 29/98 (29%), Positives = 53/98 (53%)
Frame = +1
Query: 142 EAIKKKMQMLKLDKENAIDRAEQAESDKKAAEEKCKQVEEELTHLQKKLKGTEDELDKYS 321
E + +K+ +++ D E A +RAE +E + EE+ + +++ L L + D+Y
Sbjct: 163 EEVARKLVIIESDLERAEERAELSEGQVRQLEEQLRIMDQTLKALMAAEDKYSQKEDRYE 222
Query: 322 ENLKDAQEKLELSEKKASDAEGDVAALNRRIQLVEEEL 435
E +K +KL+ +E +A AE V L + I +E+EL
Sbjct: 223 EEIKVLSDKLKEAETRAEFAERSVTKLEKSIDDLEDEL 260
Score = 25.0 bits (53), Expect(2) = 2e-68
Identities = 11/17 (64%), Positives = 14/17 (81%)
Frame = +3
Query: 741 QHLKSLEAASEKYSEKE 791
Q LK+L AA +KYS+KE
Sbjct: 202 QTLKALMAAEDKYSQKE 218
>gi|4507649|ref|NP_003280.1| (NM_003289) tropomyosin 2 (beta) [Homo
sapiens]
Length = 284
Score = 252 bits (644), Expect(2) = 7e-68
Identities = 134/200 (67%), Positives = 154/200 (77%)
Frame = +1
Query: 139 MEAIKKKMQMLKLDKENAIDRAEQAESDKKAAEEKCKQVEEELTHLQKKLKGTEDELDKY 318
M+AIKKKMQMLKLDKENAIDRAEQAE+DKK AE++CKQ+EEE LQKKLKGTEDE++KY
Sbjct: 1 MDAIKKKMQMLKLDKENAIDRAEQAEADKKQAEDRCKQLEEEQQALQKKLKGTEDEVEKY 60
Query: 319 SENLKDAQEKLELSEKKASDAEGDVAALNRRIQLVEEELDRAQERXXXXXXXXXXXXXXX 498
SE++K+AQEKLE +EKKA+DAE DVA+LNRRIQLVEEELDRAQER
Sbjct: 61 SESVKEAQEKLEQAEKKATDAEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAA 120
Query: 499 XXXXRGMKVIENRAMKDEEKMEIQEMQLXEAKHIAEEADRKYEEVARKLVIXXXXXXXXX 678
RGMKVIENRAMKDEEKME+QEMQL EAKHIAE++DRKYEEVARKLVI
Sbjct: 121 DESERGMKVIENRAMKDEEKMELQEMQLKEAKHIAEDSDRKYEEVARKLVILEGELERSE 180
Query: 679 XXXXVSELKCGDL*EETQNV 738
V+E + L EE + +
Sbjct: 181 ERAEVAESRARQLEEELRTM 200
Score = 58.5 bits (140), Expect = 5e-09
Identities = 35/103 (33%), Positives = 59/103 (56%)
Frame = +1
Query: 142 EAIKKKMQMLKLDKENAIDRAEQAESDKKAAEEKCKQVEEELTHLQKKLKGTEDELDKYS 321
E + +K+ +L+ + E + +RAE AES + EE+ + +++ L L + + DKY
Sbjct: 163 EEVARKLVILEGELERSEERAEVAESRARQLEEELRTMDQALKSLMASEEEYSTKEDKYE 222
Query: 322 ENLKDAQEKLELSEKKASDAEGDVAALNRRIQLVEEELDRAQE 450
E +K +EKL+ +E +A AE VA L + I +EE L A+E
Sbjct: 223 EEIKLLEEKLKEAETRAEFAERSVAKLEKTIDDLEETLASAKE 265
Score = 23.5 bits (49), Expect(2) = 7e-68
Identities = 11/17 (64%), Positives = 13/17 (75%)
Frame = +3
Query: 741 QHLKSLEAASEKYSEKE 791
Q LKSL A+ E+YS KE
Sbjct: 202 QALKSLMASEEEYSTKE 218
>gi|4507651|ref|NP_003281.1| (NM_003290) tropomyosin 4 [Homo
sapiens]
Length = 248
Score = 167 bits (423), Expect(2) = 6e-45
Identities = 91/160 (56%), Positives = 106/160 (65%)
Frame = +1
Query: 265 LTHLQKKLKGTEDELDKYSENLKDAQEKLELSEKKASDAEGDVAALNRRIQLVEEELDRA 444
L +++K++ + + D+ + + Q +L+ ++ AEGDVAALNRRIQLVEEELDRA
Sbjct: 7 LEAVKRKIQALQQQADEAEDRAQGLQRELDGERERREKAEGDVAALNRRIQLVEEELDRA 66
Query: 445 QERXXXXXXXXXXXXXXXXXXXRGMKVIENRAMKDEEKMEIQEMQLXEAKHIAEEADRKY 624
QER RGMKVIENRAMKDEEKMEIQEMQL EAKHIAEEADRKY
Sbjct: 67 QERLATALQKLEEAEKAADESERGMKVIENRAMKDEEKMEIQEMQLKEAKHIAEEADRKY 126
Query: 625 EEVARKLVIXXXXXXXXXXXXXVSELKCGDL*EETQNVTN 744
EEVARKLVI VSELKCGDL EE +NVTN
Sbjct: 127 EEVARKLVILEGELERAEERAEVSELKCGDLEEELKNVTN 166
Score = 56.2 bits (134), Expect = 3e-08
Identities = 35/103 (33%), Positives = 58/103 (55%)
Frame = +1
Query: 142 EAIKKKMQMLKLDKENAIDRAEQAESDKKAAEEKCKQVEEELTHLQKKLKGTEDELDKYS 321
E + +K+ +L+ + E A +RAE +E EE+ K V L L+ + ++ DKY
Sbjct: 127 EEVARKLVILEGELERAEERAEVSELKCGDLEEELKNVTNNLKSLEAASEKYSEKEDKYE 186
Query: 322 ENLKDAQEKLELSEKKASDAEGDVAALNRRIQLVEEELDRAQE 450
E +K +KL+ +E +A AE VA L + I +EE+L +A+E
Sbjct: 187 EEIKLLSDKLKEAETRAEFAERTVAKLEKTIDDLEEKLAQAKE 229
Score = 32.0 bits (71), Expect(2) = 6e-45
Identities = 15/16 (93%), Positives = 16/16 (99%)
Frame = +3
Query: 744 HLKSLEAASEKYSEKE 791
+LKSLEAASEKYSEKE
Sbjct: 167 NLKSLEAASEKYSEKE 182
>gi|22748619|ref|NP_689476.1| (NM_152263) tropomyosin 3 [Homo
sapiens]
Length = 243
Score = 155 bits (392), Expect(2) = 4e-40
Identities = 94/202 (46%), Positives = 115/202 (56%)
Frame = +1
Query: 139 MEAIKKKMQMLKLDKENAIDRAEQAESDKKAAEEKCKQVEEELTHLQKKLKGTEDELDKY 318
MEAIKKKMQMLKLDKENA+DRAEQAE AE+K
Sbjct: 2 MEAIKKKMQMLKLDKENALDRAEQAE-----AEQK------------------------- 31
Query: 319 SENLKDAQEKLELSEKKASDAEGDVAALNRRIQLVEEELDRAQERXXXXXXXXXXXXXXX 498
+E+++ E ++AA+ ++++ E+ELDRAQER
Sbjct: 32 ------------QAEERSKQLEDELAAMQKKLKGTEDELDRAQERLATALQKLEEAEKAA 79
Query: 499 XXXXRGMKVIENRAMKDEEKMEIQEMQLXEAKHIAEEADRKYEEVARKLVIXXXXXXXXX 678
RGMKVIENRA+KDEEKME+QE+QL EAKHIAEEADRKYEEVARKLVI
Sbjct: 80 DESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEEVARKLVIIEGDLERTE 139
Query: 679 XXXXVSELKCGDL*EETQNVTN 744
++E KC +L EE +NVTN
Sbjct: 140 ERAELAESKCSELEEELKNVTN 161
Score = 57.8 bits (138), Expect = 9e-09
Identities = 34/98 (34%), Positives = 54/98 (54%)
Frame = +1
Query: 142 EAIKKKMQMLKLDKENAIDRAEQAESDKKAAEEKCKQVEEELTHLQKKLKGTEDELDKYS 321
E + +K+ +++ D E +RAE AES EE+ K V L L+ + + + DKY
Sbjct: 122 EEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKYE 181
Query: 322 ENLKDAQEKLELSEKKASDAEGDVAALNRRIQLVEEEL 435
E +K +KL+ +E +A AE VA L + I +E+EL
Sbjct: 182 EEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDEL 219
Score = 27.7 bits (60), Expect(2) = 4e-40
Identities = 12/16 (75%), Positives = 15/16 (93%)
Frame = +3
Query: 744 HLKSLEAASEKYSEKE 791
+LKSLEA +EKYS+KE
Sbjct: 162 NLKSLEAQAEKYSQKE 177
>gi|24119203|ref|NP_705935.1| (NM_153649) tropomyosin 3 [Homo
sapiens]
Length = 248
Score = 136 bits (343), Expect(2) = 2e-34
Identities = 73/151 (48%), Positives = 95/151 (62%)
Frame = +1
Query: 274 LQKKLKGTEDELDKYSENLKDAQEKLELSEKKASDAEGDVAALNRRIQLVEEELDRAQER 453
+++K++ + + D E + Q ++E + AE +VA+LNRRIQLVEEELDRAQER
Sbjct: 10 VKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQER 69
Query: 454 XXXXXXXXXXXXXXXXXXXRGMKVIENRAMKDEEKMEIQEMQLXEAKHIAEEADRKYEEV 633
RGMKVIENRA+KDEEKME+QE+QL EAKHIAEEADRKYEEV
Sbjct: 70 LATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEEV 129
Query: 634 ARKLVIXXXXXXXXXXXXXVSELKCGDL*EE 726
ARKLVI ++E +C ++ E+
Sbjct: 130 ARKLVIIEGDLERTEERAELAESRCREMDEQ 160
Score = 52.0 bits (123), Expect = 5e-07
Identities = 31/103 (30%), Positives = 57/103 (55%)
Frame = +1
Query: 142 EAIKKKMQMLKLDKENAIDRAEQAESDKKAAEEKCKQVEEELTHLQKKLKGTEDELDKYS 321
E + +K+ +++ D E +RAE AES + +E+ + +++ L L + + DKY
Sbjct: 127 EEVARKLVIIEGDLERTEERAELAESRCREMDEQIRLMDQNLKCLSAAEEKYSQKEDKYE 186
Query: 322 ENLKDAQEKLELSEKKASDAEGDVAALNRRIQLVEEELDRAQE 450
E +K +KL+ +E +A AE VA L + I +E++L +E
Sbjct: 187 EEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKE 229
Score = 27.3 bits (59), Expect(2) = 2e-34
Identities = 12/17 (70%), Positives = 14/17 (81%)
Frame = +3
Query: 741 QHLKSLEAASEKYSEKE 791
Q+LK L AA EKYS+KE
Sbjct: 166 QNLKCLSAAEEKYSQKE 182
>gi|24431997|ref|NP_078857.2| (NM_024581) chromosome 6 open reading
frame 60 [Homo sapiens]
Length = 936
Score = 50.4 bits (119), Expect = 1e-06
Identities = 46/180 (25%), Positives = 83/180 (45%), Gaps = 11/180 (6%)
Frame = +1
Query: 127 HCPAMEAI-------KKKMQMLKLDKENAIDRAEQAESDKKAAEEKCKQVEEELTHLQKK 285
H A+EA+ KKK+QM D EQ DK EE Q+++EL +L++
Sbjct: 370 HHMAIEAVHSNAIRDKKKLQM---------DLEEQHNKDKLNLEEDKNQLQQELENLKEV 420
Query: 286 LKGTEDELDKYSENLKDAQEKLELSEKKASDAEGDVAALNRRIQLVEEELDRAQERXXXX 465
L ED+L+ ++ + Q+ + SE+ AEG +A+L + ++ ELD ++
Sbjct: 421 L---EDKLNTANQEIGHLQDMVRKSEQGLGSAEGLIASLQDSQERLQNELDLTKD-SLKE 476
Query: 466 XXXXXXXXXXXXXXXRGMKVIENRAMKDEEKMEIQEM----QLXEAKHIAEEADRKYEEV 633
R AMK+EEK+++ +M ++ +++ +E + EE+
Sbjct: 477 TKDALLNVEGELEQERQQHEETIAAMKEEEKLKVDKMAHDLEIKWTENLRQECSKLREEL 536
Score = 29.3 bits (64), Expect = 3.4
Identities = 24/108 (22%), Positives = 52/108 (47%), Gaps = 6/108 (5%)
Frame = +1
Query: 127 HCPAMEAIK----KKMQMLKLDKENAIDRAEQAESDKKAAEEKCK--QVEEELTHLQKKL 288
H A++ ++ +++ K++ E +ID S +++ E C+ ++EEL H + +
Sbjct: 709 HAAAIDLLRHNHHQELAAAKMELERSIDI-----SRRQSKEHICRITDLQEELRHREHHI 763
Query: 289 KGTEDELDKYSENLKDAQEKLELSEKKASDAEGDVAALNRRIQLVEEE 432
+ E+ EN+ ++LE K+ + N++I+L E E
Sbjct: 764 SELDKEVQHLHENISALTKELEFKGKEILRIRSE---SNQQIRLEEME 808
>gi|21735548|ref|NP_009117.2| (NM_007186) centrosomal protein 2;
centrosome associated protein; centrosomal
Nek2-associated protein 1 [Homo sapiens]
Length = 2442
Score = 48.9 bits (115), Expect = 4e-06
Identities = 38/168 (22%), Positives = 78/168 (45%), Gaps = 9/168 (5%)
Frame = +1
Query: 136 AMEAIKKKMQMLKLDKENA-----IDRAEQAES----DKKAAEEKCKQVEEELTHLQKKL 288
A++ + Q+L+L++EN ++ AEQA + D AE++ + + E+ THL+ +L
Sbjct: 609 ALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQL 668
Query: 289 KGTEDELDKYSENLKDAQEKLELSEKKASDAEGDVAALNRRIQLVEEELDRAQERXXXXX 468
+ E+ + +L+D QE+ E +KK S++ A +++ + +E R +E
Sbjct: 669 QKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAV 728
Query: 469 XXXXXXXXXXXXXXRGMKVIENRAMKDEEKMEIQEMQLXEAKHIAEEA 612
++ +E +D + + Q L AK + E +
Sbjct: 729 QEKEALVREKAALEVRLQAVE----RDRQDLAEQLQGLSSAKELLESS 772
Score = 31.2 bits (69), Expect = 0.90
Identities = 29/170 (17%), Positives = 72/170 (42%), Gaps = 1/170 (0%)
Frame = +1
Query: 139 MEAIKKKMQMLKLDKENAIDRAE-QAESDKKAAEEKCKQVEEELTHLQKKLKGTEDELDK 315
+E +++ M++ KL ++ + Q + ++ +E +Q ++L LQ+
Sbjct: 948 LERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQE----------- 996
Query: 316 YSENLKDAQEKLELSEKKASDAEGDVAALNRRIQLVEEELDRAQERXXXXXXXXXXXXXX 495
E+ Q+K++L +K+ D + + A + +LVE+E+
Sbjct: 997 --ESSSLLQDKMDL-QKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELERE 1053
Query: 496 XXXXXRGMKVIENRAMKDEEKMEIQEMQLXEAKHIAEEADRKYEEVARKL 645
+ E R + +E I++ +L + +EA + +E++ ++
Sbjct: 1054 KASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQM 1103
>gi|6005904|ref|NP_009045.1| (NM_007114) TATA element modulatory
factor 1 [Homo sapiens]
Length = 1093
Score = 48.5 bits (114), Expect = 5e-06
Identities = 44/178 (24%), Positives = 74/178 (40%), Gaps = 16/178 (8%)
Frame = +1
Query: 154 KKMQMLKLDKENAID--RAEQAESDKKAAE--EKCKQVEEELTHLQKKLKGTEDELDKYS 321
+K+ +L N I RA+ E++ A+ +K K++EEEL HL++ L G E+ ++
Sbjct: 563 EKLSKQQLHNSNIIKKLRAKDKENENMVAKLNKKVKELEEELQHLKQVLDGKEEVEKQHR 622
Query: 322 ENLKDAQEKLELSEKKASDAEGDVAALNRRIQLVEEELDRAQERXX--XXXXXXXXXXXX 495
EN+K +E EK + D+ L + + ++ LD A +
Sbjct: 623 ENIKKLNSMVERQEKDLGRLQVDMDELEEKNRSIQAALDSAYKELTDLHKANAAKDSEAQ 682
Query: 496 XXXXXRGMKVIE----------NRAMKDEEKMEIQEMQLXEAKHIAEEADRKYEEVAR 639
R MK E A + +E + IQ L A E+A + E+ R
Sbjct: 683 EAALSREMKAKEELSAALEKAQEEARQQQETLAIQVGDLRLALQRTEQAAARKEDYLR 740
Score = 33.5 bits (75), Expect = 0.18
Identities = 26/124 (20%), Positives = 56/124 (44%), Gaps = 20/124 (16%)
Frame = +1
Query: 139 MEAIKKKMQMLKLDKENAIDRAEQAES-------DKKAAEEKCKQVEEELT--------- 270
M +K++ + K+ R +AE ++ AA+++ K ++EEL
Sbjct: 486 MFRVKEESSSISSLKDEFTQRIAEAEKKVQLACKERDAAKKEIKNIKEELATRLNSSETA 545
Query: 271 ----HLQKKLKGTEDELDKYSENLKDAQEKLELSEKKASDAEGDVAALNRRIQLVEEELD 438
++++G +E +K S+ ++ K + E VA LN++++ +EEEL
Sbjct: 546 DLLKEKDEQIRGLMEEGEKLSKQQLHNSNIIKKLRAKDKENENMVAKLNKKVKELEEELQ 605
Query: 439 RAQE 450
++
Sbjct: 606 HLKQ 609
Score = 27.7 bits (60), Expect = 9.9
Identities = 36/188 (19%), Positives = 73/188 (38%), Gaps = 23/188 (12%)
Frame = +1
Query: 151 KKKMQMLKLDKENAIDRAEQAESDKKAAEEKCKQVEEELTHLQKKLKGTEDELDKYSENL 330
K++ Q+L L KE A+ EE +++E+ ++++ D++++ +
Sbjct: 460 KREAQLLSLSKEKAL------------LEEAFDNLKDEMFRVKEESSSISSLKDEFTQRI 507
Query: 331 KDAQEKLELSEKKASDAEGDVAALNRRIQLVEEEL----------DRAQERXXXXXXXXX 480
+A EKK A + A + I+ ++EEL D +E+
Sbjct: 508 AEA-------EKKVQLACKERDAAKKEIKNIKEELATRLNSSETADLLKEKDEQIRGLME 560
Query: 481 XXXXXXXXXXRGMKVIENRAMKDEE----------KMEIQEMQLXEAKHI---AEEADRK 621
+I+ KD+E K++ E +L K + EE +++
Sbjct: 561 EGEKLSKQQLHNSNIIKKLRAKDKENENMVAKLNKKVKELEEELQHLKQVLDGKEEVEKQ 620
Query: 622 YEEVARKL 645
+ E +KL
Sbjct: 621 HRENIKKL 628
>gi|7669506|ref|NP_005954.2| (NM_005963) myosin, heavy polypeptide 1,
skeletal muscle, adult; myosin heavy chain IIx/d [Homo
sapiens]
Length = 1939
Score = 45.1 bits (105), Expect = 6e-05
Identities = 29/110 (26%), Positives = 61/110 (55%), Gaps = 8/110 (7%)
Frame = +1
Query: 139 MEAIKKKMQM-LKLDKENAIDRAEQAESDKKAAEEKCKQVEEELTHLQKKLKG------- 294
+E K+K++ LKL +E+A+D E+DK+ +EK K+ E E++ LQ K++
Sbjct: 1052 LERAKRKLEGDLKLAQESAMD----IENDKQQLDEKLKKKEFEMSGLQSKIEDEQALGMQ 1107
Query: 295 TEDELDKYSENLKDAQEKLELSEKKASDAEGDVAALNRRIQLVEEELDRA 444
+ ++ + +++ +E++E + AE + L+R ++ + E L+ A
Sbjct: 1108 LQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEA 1157
Score = 38.9 bits (89), Expect = 0.004
Identities = 25/103 (24%), Positives = 55/103 (53%), Gaps = 1/103 (0%)
Frame = +1
Query: 148 IKKKMQMLKLDKENAIDRAEQAESDKKAAEEKCKQVEEELTHLQKKLKGTEDELDKYSEN 327
I+ +M+ + + NA ++A++A +D E+ K+ ++ HL++ K E +
Sbjct: 1741 IQGEMEDIIQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLE-------QT 1793
Query: 328 LKDAQEKLELSEKKA-SDAEGDVAALNRRIQLVEEELDRAQER 453
+KD Q +L+ +E+ A + + L R++ +E E++ Q+R
Sbjct: 1794 VKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKR 1836
Score = 37.7 bits (86), Expect = 0.010
Identities = 34/169 (20%), Positives = 65/169 (38%)
Frame = +1
Query: 139 MEAIKKKMQMLKLDKENAIDRAEQAESDKKAAEEKCKQVEEELTHLQKKLKGTEDELDKY 318
+E ++ + +++D E A + E D K A+E +E + L +KLK E E+
Sbjct: 1038 LEGSLEQEKKIRMDLERA---KRKLEGDLKLAQESAMDIENDKQQLDEKLKKKEFEMSGL 1094
Query: 319 SENLKDAQEKLELSEKKASDAEGDVAALNRRIQLVEEELDRAQERXXXXXXXXXXXXXXX 498
++D Q +KK + L RI+ +EEE++ +
Sbjct: 1095 QSKIEDEQALGMQLQKK-------IKELQARIEELEEEIEAERASRAKAEKQRSDLSREL 1147
Query: 499 XXXXRGMKVIENRAMKDEEKMEIQEMQLXEAKHIAEEADRKYEEVARKL 645
++ E + +E + + + EEA ++E A L
Sbjct: 1148 EEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATL 1196
Score = 37.7 bits (86), Expect = 0.010
Identities = 32/150 (21%), Positives = 63/150 (41%), Gaps = 1/150 (0%)
Frame = +1
Query: 148 IKKKMQMLKLDKENAIDRAEQAESDKKA-AEEKCKQVEEELTHLQKKLKGTEDELDKYSE 324
+++KM L +K N + QAE+D A AEE+C Q+ + L+ K+K + + E
Sbjct: 877 LEEKMVTLMQEK-NDLQLQVQAEADSLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEE 935
Query: 325 NLKDAQEKLELSEKKASDAEGDVAALNRRIQLVEEELDRAQERXXXXXXXXXXXXXXXXX 504
+ K E + S+ + D+ L + VE+E + +
Sbjct: 936 INAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAK 995
Query: 505 XXRGMKVIENRAMKDEEKMEIQEMQLXEAK 594
+ E +A+++ + + ++Q E K
Sbjct: 996 LTK-----EKKALQEAHQQTLDDLQAEEDK 1020
Score = 36.6 bits (83), Expect = 0.021
Identities = 37/162 (22%), Positives = 70/162 (42%)
Frame = +1
Query: 139 MEAIKKKMQMLKLDKENAIDRAEQAESDKKAAEEKCKQVEEELTHLQKKLKGTEDELDKY 318
+E +K++ + L+ + + ++ + E+ KQVE+E + LQ L+ E L+
Sbjct: 1499 LETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQAALEEAEASLE-- 1556
Query: 319 SENLKDAQEKLELSEKKASDAEGDVAALNRRIQLVEEELDRAQERXXXXXXXXXXXXXXX 498
E K + +LEL++ K+ ++R+I +EE+D+ +
Sbjct: 1557 HEEGKILRIQLELNQVKSE--------VDRKIAEKDEEIDQMKRNHIRIVESMQSTLDAE 1608
Query: 499 XXXXRGMKVIENRAMKDEEKMEIQEMQLXEAKHIAEEADRKY 624
++ + D +MEI QL A +A EA R Y
Sbjct: 1609 IRSRNDAIRLKKKMEGDLNEMEI---QLNHANRMAAEALRNY 1647
Score = 30.4 bits (67), Expect = 1.5
Identities = 23/88 (26%), Positives = 47/88 (53%), Gaps = 6/88 (6%)
Frame = +1
Query: 205 EQAESDKKAA--EEKCKQVEEELTHLQKKLKGTEDELDKYSENLKDAQEKLELSEKKASD 378
+ AE++K+ A +E+ ++ +EEL + K K E+++ + D Q +++ +D
Sbjct: 845 KSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADSLAD 904
Query: 379 AEGDVAAL-NRRIQL---VEEELDRAQE 450
AE L +IQL ++E +RA++
Sbjct: 905 AEERCDQLIKTKIQLEAKIKEVTERAED 932
>gi|4503469|ref|NP_003557.1| (NM_003566) early endosome antigen 1,
162kD; early endosome-associated protein [Homo sapiens]
Length = 1410
Score = 44.7 bits (104), Expect = 8e-05
Identities = 36/112 (32%), Positives = 64/112 (57%), Gaps = 5/112 (4%)
Frame = +1
Query: 130 CPAMEAIKKKMQMLKLDKENAIDRAEQAESDKKAAEEKCKQVEEELTHLQKKLKGTEDEL 309
C A++ I+K+ + +KE ++++ AE + E KC+Q E+E+T L ++LK + E
Sbjct: 1102 CKALQDIQKEKSLK--EKELVNEKSKLAEIE----EIKCRQ-EKEITKLNEELKSHKLES 1154
Query: 310 DKYSENLKDA-----QEKLELSEKKASDAEGDVAALNRRIQLVEEELDRAQE 450
K NLKDA Q+KLEL + KA + V R Q++++++ + +E
Sbjct: 1155 IKEITNLKDAKQLLIQQKLEL-QGKADSLKAAVEQEKRNQQILKDQVKKEEE 1205
Score = 33.9 bits (76), Expect = 0.14
Identities = 23/100 (23%), Positives = 48/100 (48%)
Frame = +1
Query: 151 KKKMQMLKLDKENAIDRAEQAESDKKAAEEKCKQVEEELTHLQKKLKGTEDELDKYSENL 330
+KK Q+ L E I ++ E + K ++++LT ++L ++++ N
Sbjct: 970 QKKKQIEALQGELKIAVLQKTELENK--------LQQQLTQAAQELAAEKEKISVLQNNY 1021
Query: 331 KDAQEKLELSEKKASDAEGDVAALNRRIQLVEEELDRAQE 450
+ +QE + + E ++ A + ++ VEE+L AQE
Sbjct: 1022 EKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQE 1061
Score = 32.7 bits (73), Expect = 0.31
Identities = 20/108 (18%), Positives = 53/108 (48%), Gaps = 3/108 (2%)
Frame = +1
Query: 139 MEAIKKKMQMLKLDKENAIDRAEQAESDKKAA---EEKCKQVEEELTHLQKKLKGTEDEL 309
++ K+ + +L+ ++E+ + + E + +EK +++E+T L + +K +
Sbjct: 532 LQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQDEVTQLTENVKNQSESH 591
Query: 310 DKYSENLKDAQEKLELSEKKASDAEGDVAALNRRIQLVEEELDRAQER 453
+ ENL D ++ + + A D V +L + + +L+ ++E+
Sbjct: 592 KQAQENLHDQVQEQKAHLRAAQDR---VLSLETSVNELNSQLNESKEK 636
Score = 31.6 bits (70), Expect = 0.69
Identities = 19/100 (19%), Positives = 51/100 (51%), Gaps = 11/100 (11%)
Frame = +1
Query: 142 EAIKKKMQMLKLDKENAIDRAEQAESDKKAAEE----KCKQVEEELTHLQKKLKGTEDEL 309
E +K+K+ + ++ +D+ +Q +++A ++ K ++ + +L + +++ + ++
Sbjct: 467 EQLKEKVTN-STELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGEKDQKI 525
Query: 310 DKYSENLKDAQEKLELSEKKASD-------AEGDVAALNR 408
L+ ++E + L EK+ D EG+ A LN+
Sbjct: 526 QNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQ 565
Score = 27.7 bits (60), Expect = 9.9
Identities = 19/102 (18%), Positives = 46/102 (44%)
Frame = +1
Query: 142 EAIKKKMQMLKLDKENAIDRAEQAESDKKAAEEKCKQVEEELTHLQKKLKGTEDELDKYS 321
EA + + +L E +D+ +Q + K ++EE+L + +LDK
Sbjct: 432 EAHGRLKEQRQLSSEKLMDKEQQVAD----LQLKLSRLEEQLKEKVTNSTELQHQLDKTK 487
Query: 322 ENLKDAQEKLELSEKKASDAEGDVAALNRRIQLVEEELDRAQ 447
+ ++ Q + + K +A+ D+ + R+I ++++ +
Sbjct: 488 QQHQEQQALQQSTTAKLREAQNDLEQVLRQIGEKDQKIQNLE 529
Database: RefSeq (Homo Sapiens/Amino Acid)
Posted date: Jul 1, 2003 6:07 AM
Number of letters in database: 10,046,356
Number of sequences in database: 19,244
Lambda K H
0.318 0.135 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 9739146
Number of Sequences: 19244
Number of extensions: 145387
Number of successful extensions: 2048
Number of sequences better than 10.0: 329
Number of HSP's better than 10.0 without gapping: 1229
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 1809
length of query: 263
length of database: 10,046,356
effective HSP length: 47
effective length of query: 216
effective length of database: 9,141,888
effective search space: 1974647808
effective search space used: 1974647808
frameshift window, decay const: 50, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 60 (27.7 bits)
Search to RefSeq (Mouse) database
Query= 20030531S-017538 (20030531S-017538) 20030531S-017538
(791 letters)
Database: RefSeq (Mus Musculus/Amino Acid)
15,330 sequences; 7,155,815 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
Alignment gi|11875203|ref|NP_033442.2| (NM_009416) tropomyosin 2, beta [M... 268 2e-73
Alignment gi|31560030|ref|NP_077745.2| (NM_024427) tropomyosin 1, alpha; ... 266 2e-73
Alignment gi|13928666|ref|NP_071709.1| (NM_022314) tropomyosin 3, gamma; ... 263 1e-72
Alignment gi|6754784|ref|NP_034994.1| (NM_010864) myosin Va; flailer; dil... 45 3e-05
Alignment gi|19745146|ref|NP_034211.1| (NM_010081) dystonin isoform e; bu... 43 2e-04
Alignment gi|16716511|ref|NP_444434.1| (NM_053204) Rab6-interacting prote... 41 8e-04
Alignment gi|6754774|ref|NP_034986.1| (NM_010856) myosin, heavy polypepti... 41 8e-04
Alignment gi|31981983|ref|NP_033313.2| (NM_009287) stromal interaction mo... 41 8e-04
Alignment gi|9910570|ref|NP_064322.1| (NM_019938) polyamine modulated fac... 40 0.001
Alignment gi|6679671|ref|NP_031969.1| (NM_007943) epidermal growth factor... 40 0.001
>gi|11875203|ref|NP_033442.2| (NM_009416) tropomyosin 2, beta [Mus
musculus]
Length = 284
Score = 268 bits (685), Expect(2) = 2e-73
Identities = 142/202 (70%), Positives = 159/202 (78%)
Frame = +1
Query: 139 MEAIKKKMQMLKLDKENAIDRAEQAESDKKAAEEKCKQVEEELTHLQKKLKGTEDELDKY 318
M+AIKKKMQMLKLDKENAIDRAEQAE+DKK AE++CKQ+EEE LQKKLKGTEDE++KY
Sbjct: 1 MDAIKKKMQMLKLDKENAIDRAEQAEADKKQAEDRCKQLEEEQQALQKKLKGTEDEVEKY 60
Query: 319 SENLKDAQEKLELSEKKASDAEGDVAALNRRIQLVEEELDRAQERXXXXXXXXXXXXXXX 498
SE++KDAQEKLE +EKKA+DAE DVA+LNRRIQLVEEELDRAQER
Sbjct: 61 SESVKDAQEKLEQAEKKATDAEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAA 120
Query: 499 XXXXRGMKVIENRAMKDEEKMEIQEMQLXEAKHIAEEADRKYEEVARKLVIXXXXXXXXX 678
RGMKVIENRAMKDEEKME+QEMQL EAKHIAE++DRKYEEVARKLVI
Sbjct: 121 DESERGMKVIENRAMKDEEKMELQEMQLKEAKHIAEDSDRKYEEVARKLVILEGELERSE 180
Query: 679 XXXXVSELKCGDL*EETQNVTN 744
V+E KCGDL EE + VTN
Sbjct: 181 ERAEVAESKCGDLEEELKIVTN 202
Score = 55.8 bits (133), Expect = 2e-08
Identities = 38/105 (36%), Positives = 58/105 (55%), Gaps = 7/105 (6%)
Frame = +1
Query: 142 EAIKKKMQMLKLDKENAIDRAEQAESDKKAAEEKCKQVEEELTHLQKKLKGTEDELDKYS 321
E + +K+ +L+ + E + +RAE AES KC +EEEL + LK E + DKYS
Sbjct: 163 EEVARKLVILEGELERSEERAEVAES-------KCGDLEEELKIVTNNLKSLEAQADKYS 215
Query: 322 -------ENLKDAQEKLELSEKKASDAEGDVAALNRRIQLVEEEL 435
E +K +EKL+ +E +A AE VA L + I +E+E+
Sbjct: 216 TKEDKYEEEIKLLEEKLKEAETRAEFAERSVAKLEKTIDDLEDEV 260
Score = 25.4 bits (54), Expect(2) = 2e-73
Identities = 11/16 (68%), Positives = 14/16 (86%)
Frame = +3
Query: 744 HLKSLEAASEKYSEKE 791
+LKSLEA ++KYS KE
Sbjct: 203 NLKSLEAQADKYSTKE 218
>gi|31560030|ref|NP_077745.2| (NM_024427) tropomyosin 1, alpha;
alpha tropomyosin [Mus musculus]
Length = 284
Score = 266 bits (679), Expect(2) = 2e-73
Identities = 142/202 (70%), Positives = 158/202 (77%)
Frame = +1
Query: 139 MEAIKKKMQMLKLDKENAIDRAEQAESDKKAAEEKCKQVEEELTHLQKKLKGTEDELDKY 318
M+AIKKKMQMLKLDKENA+DRAEQAE+DKKAAE++ KQ+E+EL LQKKLKGTEDELDKY
Sbjct: 1 MDAIKKKMQMLKLDKENALDRAEQAEADKKAAEDRSKQLEDELVSLQKKLKGTEDELDKY 60
Query: 319 SENLKDAQEKLELSEKKASDAEGDVAALNRRIQLVEEELDRAQERXXXXXXXXXXXXXXX 498
SE LKDAQEKLEL+EKKA+DAE DVA+LNRRIQLVEEELDRAQER
Sbjct: 61 SEALKDAQEKLELAEKKATDAEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAA 120
Query: 499 XXXXRGMKVIENRAMKDEEKMEIQEMQLXEAKHIAEEADRKYEEVARKLVIXXXXXXXXX 678
RGMKVIE+RA KDEEKMEIQE+QL EAKHIAE+ADRKYEEVARKLVI
Sbjct: 121 DESERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEEVARKLVIIESDLERAE 180
Query: 679 XXXXVSELKCGDL*EETQNVTN 744
+SE KC +L EE + VTN
Sbjct: 181 ERAELSEGKCAELEEELKTVTN 202
Score = 57.0 bits (136), Expect = 1e-08
Identities = 33/103 (32%), Positives = 56/103 (54%)
Frame = +1
Query: 142 EAIKKKMQMLKLDKENAIDRAEQAESDKKAAEEKCKQVEEELTHLQKKLKGTEDELDKYS 321
E + +K+ +++ D E A +RAE +E EE+ K V L L+ + + + DKY
Sbjct: 163 EEVARKLVIIESDLERAEERAELSEGKCAELEEELKTVTNNLKSLEAQAEKYSQKEDKYE 222
Query: 322 ENLKDAQEKLELSEKKASDAEGDVAALNRRIQLVEEELDRAQE 450
E +K +KL+ +E +A AE V L + I +EE++ A+E
Sbjct: 223 EEIKVLSDKLKEAETRAEFAERSVTKLEKSIDDLEEKVAHAKE 265
Score = 27.7 bits (60), Expect(2) = 2e-73
Identities = 12/16 (75%), Positives = 15/16 (93%)
Frame = +3
Query: 744 HLKSLEAASEKYSEKE 791
+LKSLEA +EKYS+KE
Sbjct: 203 NLKSLEAQAEKYSQKE 218
>gi|13928666|ref|NP_071709.1| (NM_022314) tropomyosin 3, gamma;
skalphaTM.2; tropomyosin 5 [Mus musculus]
Length = 284
Score = 263 bits (673), Expect(2) = 1e-72
Identities = 139/202 (68%), Positives = 158/202 (77%)
Frame = +1
Query: 139 MEAIKKKMQMLKLDKENAIDRAEQAESDKKAAEEKCKQVEEELTHLQKKLKGTEDELDKY 318
MEAIKKKMQMLKLDKEN +DRAEQAE+++K AEE+ KQ+E+EL +QKKLKGTEDELDKY
Sbjct: 1 MEAIKKKMQMLKLDKENVLDRAEQAEAEQKQAEERSKQLEDELATMQKKLKGTEDELDKY 60
Query: 319 SENLKDAQEKLELSEKKASDAEGDVAALNRRIQLVEEELDRAQERXXXXXXXXXXXXXXX 498
SE LKDAQEKLEL+EKKA+DAE +VA+LNRRIQLVEEELDRAQER
Sbjct: 61 SEALKDAQEKLELAEKKAADAEAEVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAA 120
Query: 499 XXXXRGMKVIENRAMKDEEKMEIQEMQLXEAKHIAEEADRKYEEVARKLVIXXXXXXXXX 678
RGMKVIENRA+KDEEKME+QE+QL EAKHIAEEADRKYEEVARKLVI
Sbjct: 121 DESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEEVARKLVIIEGDLERTE 180
Query: 679 XXXXVSELKCGDL*EETQNVTN 744
++E KC +L EE +NVTN
Sbjct: 181 ERAELAESKCSELEEELKNVTN 202
Score = 57.8 bits (138), Expect = 6e-09
Identities = 34/98 (34%), Positives = 54/98 (54%)
Frame = +1
Query: 142 EAIKKKMQMLKLDKENAIDRAEQAESDKKAAEEKCKQVEEELTHLQKKLKGTEDELDKYS 321
E + +K+ +++ D E +RAE AES EE+ K V L L+ + + + DKY
Sbjct: 163 EEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKYE 222
Query: 322 ENLKDAQEKLELSEKKASDAEGDVAALNRRIQLVEEEL 435
E +K +KL+ +E +A AE VA L + I +E+EL
Sbjct: 223 EEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDEL 260
Score = 27.7 bits (60), Expect(2) = 1e-72
Identities = 12/16 (75%), Positives = 15/16 (93%)
Frame = +3
Query: 744 HLKSLEAASEKYSEKE 791
+LKSLEA +EKYS+KE
Sbjct: 203 NLKSLEAQAEKYSQKE 218
Score = 27.3 bits (59), Expect = 9.1
Identities = 17/54 (31%), Positives = 28/54 (51%)
Frame = +1
Query: 151 KKKMQMLKLDKENAIDRAEQAESDKKAAEEKCKQVEEELTHLQKKLKGTEDELD 312
++++++L + A RAE AE E+ +E+EL + K K DELD
Sbjct: 222 EEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDELYAQKLKYKAISDELD 275
>gi|6754784|ref|NP_034994.1| (NM_010864) myosin Va; flailer; dilute
lethal-20J protein [Mus musculus]
Length = 1853
Score = 45.4 bits (106), Expect = 3e-05
Identities = 37/164 (22%), Positives = 72/164 (43%)
Frame = +1
Query: 154 KKMQMLKLDKENAIDRAEQAESDKKAAEEKCKQVEEELTHLQKKLKGTEDELDKYSENLK 333
++ + L + EN I + Q + D++ + KC L +KL E + +E L+
Sbjct: 916 ERYKKLHIGMENKIMQL-QRKVDEQNKDYKC---------LMEKLTNLEGVYNSETEKLR 965
Query: 334 DAQEKLELSEKKASDAEGDVAALNRRIQLVEEELDRAQERXXXXXXXXXXXXXXXXXXXR 513
+ E+L+LSE++A A G V +L I + ++L++ +
Sbjct: 966 NDVERLQLSEEEAKVATGRVLSLQEEIAKLRKDLEQTRSEKKSIEERADKYKQETDQLVS 1025
Query: 514 GMKVIENRAMKDEEKMEIQEMQLXEAKHIAEEADRKYEEVARKL 645
+K E + +EK + + +AK + E +RK E ++L
Sbjct: 1026 NLK--EENTLLKQEKETLNHRIVEQAKEMTETMERKLVEETKQL 1067
Score = 33.5 bits (75), Expect = 0.13
Identities = 32/108 (29%), Positives = 48/108 (43%), Gaps = 11/108 (10%)
Frame = +1
Query: 163 QMLKLDKENAIDRA--EQAESDKKAAEEKCKQVEEELTHLQKKLKGTEDELDKYSENL-- 330
++L L +E A R EQ S+KK+ EE+ + ++E L LK L + E L
Sbjct: 984 RVLSLQEEIAKLRKDLEQTRSEKKSIEERADKYKQETDQLVSNLKEENTLLKQEKETLNH 1043
Query: 331 ---KDAQEKLELSEKK----ASDAEGDVAALNRRIQLVEEELDRAQER 453
+ A+E E E+K E D+ R Q + E R +ER
Sbjct: 1044 RIVEQAKEMTETMERKLVEETKQLELDLNDERLRYQNLLNEFSRLEER 1091
>gi|19745146|ref|NP_034211.1| (NM_010081) dystonin isoform e; bullous
pemphigoid antigen 1; dystonia musculorum [Mus musculus]
Length = 2611
Score = 43.1 bits (100), Expect = 2e-04
Identities = 33/171 (19%), Positives = 78/171 (45%), Gaps = 6/171 (3%)
Frame = +1
Query: 151 KKKMQMLKLDKENAIDRAEQAESDKKAA--EEKCKQVEEELTHLQKKLKGTEDELDKYSE 324
K + +M +L E + + E+A S++KA ++K + L L++ L+ + ++YS+
Sbjct: 1337 KAEKEMRELKYELSAVQLEKASSEEKARLLKDKLDETNNTLKCLKEDLERKDQAQERYSQ 1396
Query: 325 NLKDAQEKLELSEKKASDAEGDVAALNRRIQLVEEELDRAQERXXXXXXXXXXXXXXXXX 504
L+D +L + KA + + L + + EL+ +
Sbjct: 1397 QLRDLGGQLNQTTDKAEEVRQEANDLKKIKHTYQLELESLHQEKGKLQREVDRVTRAHAL 1456
Query: 505 XXRGMKVIENR--AMKDEEKMEIQEMQLXEAK--HIAEEADRKYEEVARKL 645
R ++ + ++ A +DE+ + + +L + K H+ EE +R + ++ + +
Sbjct: 1457 AERNIQCLNSQVHASRDEKDLSEERRRLCQRKSDHLKEEFERSHAQLLQNI 1507
Score = 35.0 bits (79), Expect = 0.044
Identities = 23/100 (23%), Positives = 50/100 (50%)
Frame = +1
Query: 151 KKKMQMLKLDKENAIDRAEQAESDKKAAEEKCKQVEEELTHLQKKLKGTEDELDKYSENL 330
++K Q+ + + DR ++ + E K +EE++TH +K+ ++E DK+ +
Sbjct: 1661 EQKAQLQRAQVQELNDRLKRVQD-----ELHLKTIEEQMTH--RKMILLQEESDKFKRSA 1713
Query: 331 KDAQEKLELSEKKASDAEGDVAALNRRIQLVEEELDRAQE 450
+ ++K+E + E D++ + ++ E RAQE
Sbjct: 1714 DEFRKKMEKLMESKVVTETDLSGIKHDFVSLQRENFRAQE 1753
Score = 31.2 bits (69), Expect = 0.63
Identities = 41/188 (21%), Positives = 77/188 (40%), Gaps = 23/188 (12%)
Frame = +1
Query: 151 KKKMQMLKLDKENAIDRAEQAESDKKAAEEKCKQVEEELTHLQKKLKGT-------EDEL 309
+++++ + +KE A E+ AE + VEE L + + +L+ ED L
Sbjct: 1168 RRELETIVREKEAAERELERVRQLTAEAEARRAAVEENLRNFRSQLQENTFTRQTLEDHL 1227
Query: 310 DKYSENLKD-AQEKLELSE--KKASDAEGDVAALNRRI--------QLVEEELDRAQE-- 450
+ +L D Q+K L E ++ D E ++ L +++ Q+ E++L Q+
Sbjct: 1228 RRKDSSLSDLEQQKRALVEELQRKRDHEEELLRLVKQMERDLAFQKQVAEKQLKEKQKVE 1287
Query: 451 ---RXXXXXXXXXXXXXXXXXXXRGMKVIENRAMKDEEKMEIQEMQLXEAKHIAEEADRK 621
R R + + R ++E K ++ E+ L K E + K
Sbjct: 1288 LEARRKITEIQFSCRESAAVAQARPQRE-QGRQKEEELKQQVDELTLANRKAEKEMRELK 1346
Query: 622 YEEVARKL 645
YE A +L
Sbjct: 1347 YELSAVQL 1354
Score = 30.8 bits (68), Expect = 0.83
Identities = 28/170 (16%), Positives = 67/170 (38%)
Frame = +1
Query: 142 EAIKKKMQMLKLDKENAIDRAEQAESDKKAAEEKCKQVEEELTHLQKKLKGTEDELDKYS 321
+AI+++ ++L++ + D+ E KQ + E +K+K ED+L +
Sbjct: 1567 QAIQQRCEVLRIQADGFKDQLRNTN------EHLHKQTKTE-QDFHRKIKSLEDDLAQSQ 1619
Query: 322 ENLKDAQEKLELSEKKASDAEGDVAALNRRIQLVEEELDRAQERXXXXXXXXXXXXXXXX 501
+ + ++K + E +V +L+ + +EE R +++
Sbjct: 1620 NLVSEFKQKCDQQSMIIQKTEKEVRSLSAELSASKEEKRREEQKAQLQRAQVQELNDRLK 1679
Query: 502 XXXRGMKVIENRAMKDEEKMEIQEMQLXEAKHIAEEADRKYEEVARKLVI 651
+ + KM + + + + K A+E +K E++ V+
Sbjct: 1680 RVQDELHLKTIEEQMTHRKMILLQEESDKFKRSADEFRKKMEKLMESKVV 1729
Score = 27.7 bits (60), Expect = 7.0
Identities = 31/171 (18%), Positives = 69/171 (40%), Gaps = 2/171 (1%)
Frame = +1
Query: 136 AMEAIKKKMQMLKLDKENAIDRAEQAESDKKAAEEKCKQVEEELTHLQKKLKGTEDELDK 315
A E ++++ L D+AE +V +E L+K + EL+
Sbjct: 1390 AQERYSQQLRDLGGQLNQTTDKAE--------------EVRQEANDLKKIKHTYQLELES 1435
Query: 316 YSENLKDAQEKLELSEKKASDAEGDVAALNRRIQLVEEELDRAQERXXXXXXXXXXXXXX 495
+ Q +++ + + AE ++ LN ++ +E D ++ER
Sbjct: 1436 LHQEKGKLQREVDRVTRAHALAERNIQCLNSQVHASRDEKDLSEERRRLCQRKSDHLKEE 1495
Query: 496 XXXXXRGMKVIENRAMKDEEKMEIQEM--QLXEAKHIAEEADRKYEEVARK 642
++++N + E +IQ++ +L ++ AE +K +E+ R+
Sbjct: 1496 FERSH--AQLLQNIQAEKENNDKIQKLNKELEKSNECAETLKQKVDELTRQ 1544
>gi|16716511|ref|NP_444434.1| (NM_053204) Rab6-interacting protein 2
[Mus musculus]
Length = 1120
Score = 40.8 bits (94), Expect = 8e-04
Identities = 26/87 (29%), Positives = 51/87 (57%), Gaps = 8/87 (9%)
Frame = +1
Query: 139 MEAIKKKMQMLKLDKEN---AIDRAEQAESDKKAAEEKCKQVEEELTHLQKKLKGTEDEL 309
M ++K++++ L+ D N A+ E+A +DK+ E+ K+ + + + ++E+
Sbjct: 594 MSSLKERVKSLQADTTNTDTALTTLEEALADKERTIERLKEQRD------RDEREKQEEI 647
Query: 310 DKYSENLKDAQEKL-----ELSEKKAS 375
D Y ++LKD +EK+ +LSEK+AS
Sbjct: 648 DTYKKDLKDLREKVSLLQGDLSEKEAS 674
Score = 36.6 bits (83), Expect = 0.015
Identities = 42/230 (18%), Positives = 97/230 (41%), Gaps = 18/230 (7%)
Frame = +1
Query: 151 KKKMQMLKLDKENAIDRAEQAESDKKAAEE---KCKQVEEELTHLQKKLKGTEDELDKYS 321
+KK + LK+ E+ + +A +A + +A+ E + +Q+E E++ + + + E+D+
Sbjct: 705 QKKEECLKM--ESQLKKAHEATLEARASPEMSDRIQQLEREISRYKDESSKAQTEVDRLL 762
Query: 322 ENLKDAQEKLELSEKKASDAEG-----------DVAALNRRIQLVEEE----LDRAQERX 456
E LK+ + + +KK ++ E VA L + Q+ +++ L+ A+ R
Sbjct: 763 EILKEVENEKNDKDKKIAELESLTSRQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRRE 822
Query: 457 XXXXXXXXXXXXXXXXXXRGMKVIENRAMKDEEKMEIQEMQLXEAKHIAEEADRKYEEVA 636
++ +E + + +EM L + + A+++ EE+
Sbjct: 823 DSLSDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELL 882
Query: 637 RKLVIXXXXXXXXXXXXXVSELKCGDL*EETQNVTNT*SR*RLHLKSILK 786
+ ++ L E+ ++TN + R HL+ +L+
Sbjct: 883 MAMEKVKQELESMKAKLSSTQ---QSLAEKETHLTNLRAERRKHLEEVLE 929
>gi|6754774|ref|NP_034986.1| (NM_010856) myosin, heavy polypeptide 6,
cardiac muscle, alpha; myosin heavy chain, cardiac
muscle, adult; alpha myosin; alpha cardiac MHC;
cardiomyopathy, hypertrophic 1 [Mus musculus]
Length = 1938
Score = 40.8 bits (94), Expect = 8e-04
Identities = 38/166 (22%), Positives = 72/166 (42%), Gaps = 9/166 (5%)
Frame = +1
Query: 151 KKKMQ----MLKLDKENAIDRAEQAESDKKAAEEKCKQVEEELTHLQKKLKGTEDELDKY 318
KKKM+ L+ + E A+ AE K A + EEL KK + T L++
Sbjct: 1729 KKKMESDLTQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEEL----KKEQDTSAHLERM 1784
Query: 319 SENL----KDAQEKLELSEKKA-SDAEGDVAALNRRIQLVEEELDRAQERXXXXXXXXXX 483
+N+ KD Q +L+ +E+ A + + L R++ +E EL+ Q+R
Sbjct: 1785 KKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRK 1844
Query: 484 XXXXXXXXXRGMKVIENRAMKDEEKMEIQEMQLXEAKHIAEEADRK 621
+ + M+ ++ ++ ++++ K AEEA+ +
Sbjct: 1845 SERRIKELTYQTEEDKKNLMRLQDLVDKLQLKVKAYKRQAEEAEEQ 1890
Score = 38.1 bits (87), Expect = 0.005
Identities = 35/131 (26%), Positives = 59/131 (44%), Gaps = 26/131 (19%)
Frame = +1
Query: 139 MEAIKKKMQMLKLDKENAIDRAEQ-----AESDKKAAEEKCKQVEEELTHLQKK----LK 291
+E +KK M+ D ++ +D AEQ + + E + +++E EL QK+ +K
Sbjct: 1781 LERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENELEAEQKRNAESVK 1840
Query: 292 GTE-------------DELDKYSENLKDAQEKLELSEK----KASDAEGDVAALNRRIQL 420
G +E K L+D +KL+L K +A +AE + +
Sbjct: 1841 GMRKSERRIKELTYQTEEDKKNLMRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRK 1900
Query: 421 VEEELDRAQER 453
V+ ELD A+ER
Sbjct: 1901 VQHELDEAEER 1911
Score = 38.1 bits (87), Expect = 0.005
Identities = 32/150 (21%), Positives = 63/150 (41%), Gaps = 1/150 (0%)
Frame = +1
Query: 148 IKKKMQMLKLDKENAIDRAEQAESDK-KAAEEKCKQVEEELTHLQKKLKGTEDELDKYSE 324
+++KM L L ++N + QAE D AEE+C Q+ + L+ K+K + L+ E
Sbjct: 875 LEEKMVSL-LQEKNDLQLQVQAEQDNLNDAEERCDQLIKNKIQLEAKVKEMTERLEDEEE 933
Query: 325 NLKDAQEKLELSEKKASDAEGDVAALNRRIQLVEEELDRAQERXXXXXXXXXXXXXXXXX 504
+ K E + S+ + D+ L + VE+E + +
Sbjct: 934 MNAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAK 993
Query: 505 XXRGMKVIENRAMKDEEKMEIQEMQLXEAK 594
+ E +A+++ + + ++Q E K
Sbjct: 994 LTK-----EKKALQEAHQQALDDLQAEEDK 1018
Score = 37.4 bits (85), Expect = 0.009
Identities = 25/93 (26%), Positives = 45/93 (47%)
Frame = +1
Query: 151 KKKMQMLKLDKENAIDRAEQAESDKKAAEEKCKQVEEELTHLQKKLKGTEDELDKYSENL 330
+K+M +K + D E++E+ +K EEK + +E LQ +++ +D NL
Sbjct: 848 EKEMANMKEEFGRVKDALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQD-------NL 900
Query: 331 KDAQEKLELSEKKASDAEGDVAALNRRIQLVEE 429
DA+E+ + K E V + R++ EE
Sbjct: 901 NDAEERCDQLIKNKIQLEAKVKEMTERLEDEEE 933
Score = 37.4 bits (85), Expect = 0.009
Identities = 33/117 (28%), Positives = 56/117 (47%), Gaps = 15/117 (12%)
Frame = +1
Query: 139 MEAIKKKMQM-LKLDKENAIDRAEQAESDKKAAEEKCKQVEEELT--------------H 273
+E K+K++ LKL +E+ +D E+DK EEK K+ E +++
Sbjct: 1050 LERAKRKLEGDLKLTQESIMD----LENDKLQLEEKLKKKEFDISQQNSKIEDEQALALQ 1105
Query: 274 LQKKLKGTEDELDKYSENLKDAQEKLELSEKKASDAEGDVAALNRRIQLVEEELDRA 444
LQKKLK + +++ E L+ + EK SD L+R ++ + E L+ A
Sbjct: 1106 LQKKLKENQARIEELEEELEAERTARAKVEKLRSD-------LSRELEEISERLEEA 1155
Score = 35.8 bits (81), Expect = 0.026
Identities = 24/100 (24%), Positives = 49/100 (49%)
Frame = +1
Query: 139 MEAIKKKMQMLKLDKENAIDRAEQAESDKKAAEEKCKQVEEELTHLQKKLKGTEDELDKY 318
+E ++ + +++D E A + E D K +E +E + L++KLK E ++ +
Sbjct: 1036 LEGSLEQEKKVRMDLERA---KRKLEGDLKLTQESIMDLENDKLQLEEKLKKKEFDISQQ 1092
Query: 319 SENLKDAQEKLELSEKKASDAEGDVAALNRRIQLVEEELD 438
+ ++D Q +KK + + RI+ +EEEL+
Sbjct: 1093 NSKIEDEQALALQLQKKLKENQA-------RIEELEEELE 1125
Score = 30.4 bits (67), Expect = 1.1
Identities = 24/102 (23%), Positives = 43/102 (41%)
Frame = +1
Query: 148 IKKKMQMLKLDKENAIDRAEQAESDKKAAEEKCKQVEEELTHLQKKLKGTEDELDKYSEN 327
+KKKM+ + E + +A + S+ A++ K + L Q +L D EN
Sbjct: 1616 VKKKMEGDLNEMEIQLSQANRIASE---AQKHLKNSQAHLKDTQLQLDDAVHANDDLKEN 1672
Query: 328 LKDAQEKLELSEKKASDAEGDVAALNRRIQLVEEELDRAQER 453
+ + + L + + + V R +L E+EL ER
Sbjct: 1673 IAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSER 1714
Score = 27.7 bits (60), Expect = 7.0
Identities = 18/80 (22%), Positives = 37/80 (45%), Gaps = 3/80 (3%)
Frame = +1
Query: 148 IKKKMQMLKLDKENAI---DRAEQAESDKKAAEEKCKQVEEELTHLQKKLKGTEDELDKY 318
IK+ + DK+N + D ++ + KA + + ++ EE+ K + + ELD+
Sbjct: 1849 IKELTYQTEEDKKNLMRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEA 1908
Query: 319 SENLKDAQEKLELSEKKASD 378
E A+ ++ K+ D
Sbjct: 1909 EERADIAESQVNKLRAKSRD 1928
>gi|31981983|ref|NP_033313.2| (NM_009287) stromal interaction
molecule 1 [Mus musculus]
Length = 685
Score = 40.8 bits (94), Expect = 8e-04
Identities = 28/100 (28%), Positives = 53/100 (53%), Gaps = 4/100 (4%)
Frame = +1
Query: 151 KKKMQMLKLDKENAIDRAEQAESDKKA----AEEKCKQVEEELTHLQKKLKGTEDELDKY 318
K+ M+ + D E + RAEQ+ D + A+E+ + VE E HL+KKL+ + +
Sbjct: 238 KEHMKKMMKDLEG-LHRAEQSLHDLQERLHKAQEEHRTVEVEKVHLEKKLRDEINLAKQE 296
Query: 319 SENLKDAQEKLELSEKKASDAEGDVAALNRRIQLVEEELD 438
++ LK+ +E E + AE ++ + ++ E+EL+
Sbjct: 297 AQRLKELREGTENERSRQKYAEEELEQVREALRKAEKELE 336
>gi|9910570|ref|NP_064322.1| (NM_019938) polyamine modulated factor
1 binding protein 1; sperm tail associated protein [Mus
musculus]
Length = 1022
Score = 40.4 bits (93), Expect = 0.001
Identities = 33/168 (19%), Positives = 74/168 (43%)
Frame = +1
Query: 142 EAIKKKMQMLKLDKENAIDRAEQAESDKKAAEEKCKQVEEELTHLQKKLKGTEDELDKYS 321
EA++ ++Q LK E A ++ + ++ + ++E+ L +K++ + +
Sbjct: 472 EALRAEIQKLKDSLEEAREQLKVSDQNLTQSKEEAHLSASSLEDAHRKIENCLLQDKQKE 531
Query: 322 ENLKDAQEKLELSEKKASDAEGDVAALNRRIQLVEEELDRAQERXXXXXXXXXXXXXXXX 501
E +KD Q +L +K++S E + +R+Q + EL Q R
Sbjct: 532 EVIKDLQSQLHKLQKESSKIEEERKHNRQRLQELSSELSEGQRR--------------LS 577
Query: 502 XXXRGMKVIENRAMKDEEKMEIQEMQLXEAKHIAEEADRKYEEVARKL 645
+ +++ +DE+K++ +L + ++E+ R+ RKL
Sbjct: 578 NAEKEKSLLQKTLDEDEKKID----ELFHSTQVSEQKQRELTNSIRKL 621
Score = 37.7 bits (86), Expect = 0.007
Identities = 25/104 (24%), Positives = 50/104 (48%)
Frame = +1
Query: 142 EAIKKKMQMLKLDKENAIDRAEQAESDKKAAEEKCKQVEEELTHLQKKLKGTEDELDKYS 321
E +KK + K +E ++A+ +K A+E ++++EE +LQ EL S
Sbjct: 637 EQLKKSKEQEKALEEEIEALRQEAKRKEKMAKEHLRKLDEEKENLQA-------ELTSRS 689
Query: 322 ENLKDAQEKLELSEKKASDAEGDVAALNRRIQLVEEELDRAQER 453
+L + K S+K + ++A I +++ +LD A ++
Sbjct: 690 SHLDSSLNKYNSSQKVIQELNAEIARQKDSIMILQTQLDSAIQK 733
Score = 33.5 bits (75), Expect = 0.13
Identities = 25/141 (17%), Positives = 56/141 (38%)
Frame = +1
Query: 136 AMEAIKKKMQMLKLDKENAIDRAEQAESDKKAAEEKCKQVEEELTHLQKKLKGTEDELDK 315
A E + +K + D A+++ QA S+ K+ +Q +E L EDE+
Sbjct: 746 AYEELVRKSGNCQDDLTQALEKLTQATSETKSLNRSLQQTQERKAQL-------EDEIAA 798
Query: 316 YSENLKDAQEKLELSEKKASDAEGDVAALNRRIQLVEEELDRAQERXXXXXXXXXXXXXX 495
Y E +K +L+ + +E +V +++++ + ++ + Q +
Sbjct: 799 YEERMKKLNMELKKLQGFQQQSEQEVHNFDKKLEEMSNQVLQWQRQHQSDLKMLAAKESQ 858
Query: 496 XXXXXRGMKVIENRAMKDEEK 558
M + + DE++
Sbjct: 859 LREFQEEMATLRESLLADEKE 879
Score = 28.9 bits (63), Expect = 3.1
Identities = 21/101 (20%), Positives = 44/101 (42%)
Frame = +1
Query: 130 CPAMEAIKKKMQMLKLDKENAIDRAEQAESDKKAAEEKCKQVEEELTHLQKKLKGTEDEL 309
C ++++ ++KL E A A + E C+ + + L HLQ++ +
Sbjct: 279 CSNSLVLEREEALIKLQAEFASYTATHRHPP--TSSEDCEDITKILKHLQEQKDSQCLHV 336
Query: 310 DKYSENLKDAQEKLELSEKKASDAEGDVAALNRRIQLVEEE 432
++Y +KD + +LE ++ D+ L + + EE
Sbjct: 337 EEYQNLVKDLRMELEAVSEQKKKIMKDMMKLELDLHGLREE 377
>gi|6679671|ref|NP_031969.1| (NM_007943) epidermal growth factor
receptor pathway substrate 15; epidermal growth factor
pathway substrate 15 [Mus musculus]
Length = 897
Score = 40.4 bits (93), Expect = 0.001
Identities = 23/106 (21%), Positives = 57/106 (53%), Gaps = 2/106 (1%)
Frame = +1
Query: 139 MEAIKKKMQML--KLDKENAIDRAEQAESDKKAAEEKCKQVEEELTHLQKKLKGTEDELD 312
++A K+++Q L +LD++ A Q E + +KC + + ++ L+ ++ E ++
Sbjct: 387 LQAQKQQVQELLGELDEQKA-----QLEEQLQEVRKKCAEEAQLISSLKAEITSQESQIS 441
Query: 313 KYSENLKDAQEKLELSEKKASDAEGDVAALNRRIQLVEEELDRAQE 450
Y E L A+E+L +++ + E V + +++ +++ L +Q+
Sbjct: 442 SYEEELLKAREELSRLQQETAQLEESVESGKAQLEPLQQHLQESQQ 487
Database: RefSeq (Mus Musculus/Amino Acid)
Posted date: Jul 1, 2003 6:07 AM
Number of letters in database: 7,155,815
Number of sequences in database: 15,330
Lambda K H
0.318 0.135 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 6801550
Number of Sequences: 15330
Number of extensions: 97684
Number of successful extensions: 1173
Number of sequences better than 10.0: 205
Number of HSP's better than 10.0 without gapping: 796
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 1082
length of query: 263
length of database: 7,155,815
effective HSP length: 47
effective length of query: 216
effective length of database: 6,435,305
effective search space: 1390025880
effective search space used: 1390025880
frameshift window, decay const: 50, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 59 (27.3 bits)