BLASTX 2.2.10 [Oct-19-2004]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= 20060611S-041698
(1279 letters)
Database: RefSeqSP
1040 sequences; 434,620 total letters
Searching...done
Score E
Sequences producing significant alignments: (bits) Value
Alignment gi|NP_999407.1| factor XII [Sus scrofa] 632 0.0
Alignment gi|NP_999219.1| T-plasminogen activator [Sus scrofa] 167 5e-43
Alignment gi|NP_999110.1| plasminogen activator [Sus scrofa] 154 3e-39
Alignment gi|NP_999198.1| preproacrosin [Sus scrofa] 146 1e-36
Alignment gi|NP_001001259.1| enteropeptidase, light chain (L chain) [Sus ... 132 2e-32
Alignment gi|NP_999239.1| kallikrein [Sus scrofa] 129 2e-31
Alignment gi|NP_001001911.1| kallikrein 1, renal/pancreas/salivary [Sus s... 117 6e-28
Alignment gi|NP_999356.1| tryptase [Sus scrofa] 115 2e-27
Alignment gi|NP_998967.1| enamel matrix serine proteinase 1 [Sus scrofa] 114 7e-27
Alignment gi|NP_999274.1| pancreatic elastase II [Sus scrofa] 113 8e-27
>ref|NP_999407.1| factor XII [Sus scrofa]
Length = 616
Score = 632 bits (1629), Expect = 0.0
Identities = 303/310 (97%), Positives = 304/310 (98%)
Frame = +2
Query: 2 LTPTQSPSEHQDSPLLSREPQPTTQTPSQNLTSAWCAPPEQRGPLPSAGLVGCGQRLRKR 181
LTPTQSPSEHQDSPLLSREPQPTTQTPSQNLTSAWCAPPEQRGPLPSAGLVGCGQRLRKR
Sbjct: 306 LTPTQSPSEHQDSPLLSREPQPTTQTPSQNLTSAWCAPPEQRGPLPSAGLVGCGQRLRKR 365
Query: 182 LSSLNRIVGGLVALPGAHPYIAALYWGQNFCAGSLIAPCWVLTAAHCLQNRPAPEELTVV 361
LSSLNRIVGGLVALPGAHPYIAALYWGQNFCAGSLIAPCWVLTAAHCLQNRPAPEELTVV
Sbjct: 366 LSSLNRIVGGLVALPGAHPYIAALYWGQNFCAGSLIAPCWVLTAAHCLQNRPAPEELTVV 425
Query: 362 LGQDRHNQSCEQCQTLAVRSYRLHESYSPKTYQHDLALVRLKETADGCCAHPSPFVQPVC 541
LGQDRHNQSCEQCQTLAVRSYRLHESYSPKTYQHDLALVRLKETADGCCAHPSPFVQPVC
Sbjct: 426 LGQDRHNQSCEQCQTLAVRSYRLHESYSPKTYQHDLALVRLKETADGCCAHPSPFVQPVC 485
Query: 542 LPRSVASSAEPEGALCEVAGWGHQFEGAEEYSSFLQEAQVPLISPERCSAADVHGAAFTP 721
LPRSVASSAEPEGALCEVAGWGHQFEGAEEYSSFLQEAQVPLISPERCSAADVHGAAFTP
Sbjct: 486 LPRSVASSAEPEGALCEVAGWGHQFEGAEEYSSFLQEAQVPLISPERCSAADVHGAAFTP 545
Query: 722 GMLCAGFLEGGTDACQGDSGGPLVCEDETAERQLVLRGIVSWGSGLCDRPQPRVYTDVAN 901
GMLCAGFLEGGTDACQGDSGGPLVCEDETAERQLVLRGIVSWGSG DR +P VYTDVAN
Sbjct: 546 GMLCAGFLEGGTDACQGDSGGPLVCEDETAERQLVLRGIVSWGSGCGDRLKPGVYTDVAN 605
Query: 902 YLXXIQEHTT 931
YL IQEHTT
Sbjct: 606 YLAWIQEHTT 615
>ref|NP_999219.1| T-plasminogen activator [Sus scrofa]
Length = 562
Score = 167 bits (423), Expect = 5e-43
Identities = 107/272 (39%), Positives = 144/272 (52%), Gaps = 13/272 (4%)
Frame = +2
Query: 152 VGCGQRLRKRLSSLNRIVGGLVALPGAHPYIAALYW------GQNF-CAGSLIAPCWVLT 310
V CG LR+ RI GGL A +HP+ AA++ G+ F C G LI+ CWVL+
Sbjct: 297 VTCG--LRQYKEPQFRIKGGLYADITSHPWQAAIFVKNRRSPGERFLCGGILISSCWVLS 354
Query: 311 AAHCLQNRPAPEELTVVLGQDRHNQSCEQCQTLAVRSYRLHESYSPKTYQHDLALVRLKE 490
AAHC Q R P + VVLG+ E+ Q V Y +H+ + TY +D+AL++LK
Sbjct: 355 AAHCFQERFPPHHVRVVLGRTYRLVPGEEEQAFEVEKYIVHKEFDDDTYDNDIALLQLKS 414
Query: 491 TADGCCAHPSPFVQPVCLPRSVASSAEPEGALCEVAGWGHQFEGAEEYSSFLQEAQVPLI 670
+ CA S V+ VCLP A+ P+ CE++G+G + YS L+EA V L
Sbjct: 415 DS-LTCAQESDAVRTVCLPE--ANLQLPDWTECELSGYGKHEASSPFYSERLKEAHVRLY 471
Query: 671 SPERCSAADVHGAAFTPGMLCAGFLEGG------TDACQGDSGGPLVCEDETAERQLVLR 832
RC++ + T MLCAG G DACQGDSGGPLVC + L
Sbjct: 472 PSSRCTSKHLFNKTITNNMLCAGDTRSGGDNANLHDACQGDSGGPLVC---MKGNHMTLV 528
Query: 833 GIVSWGSGLCDRPQPRVYTDVANYLXXIQEHT 928
G++SWG G + P VYT V NYL I+++T
Sbjct: 529 GVISWGLGCGQKDVPGVYTKVTNYLNWIRDNT 560
>ref|NP_999110.1| plasminogen activator [Sus scrofa]
Length = 442
Score = 154 bits (390), Expect = 3e-39
Identities = 99/265 (37%), Positives = 134/265 (50%), Gaps = 9/265 (3%)
Frame = +2
Query: 158 CGQR-LRKRLSSLNRIVGGLVALPGAHPYIAALYWGQN------FCAGSLIAPCWVLTAA 316
CGQ+ LR R +IVGG P+ AA+Y C GSLI+PCWV++A
Sbjct: 179 CGQKALRPRF----KIVGGKSTTIENQPWFAAIYRRHRGGSVTYVCGGSLISPCWVVSAT 234
Query: 317 HCLQNRPAPEELTVVLGQDRHNQSCEQCQTLAVRSYRLHESYSPKTYQH--DLALVRLKE 490
HC N E+ V LG+ + S V LHE YS + H D+AL++++
Sbjct: 235 HCFINYQHKEDYIVYLGRQTLHSSTHGEMKFEVEKLILHEDYSADSLAHHNDIALLKIR- 293
Query: 491 TADGCCAHPSPFVQPVCLPRSVASSAEPEGALCEVAGWGHQFEGAEEYSSFLQEAQVPLI 670
T G CA PS +Q +CLP + GA CE+ G+G + Y L+ V L+
Sbjct: 294 TDKGQCAQPSRSIQTICLPP--VNGDAHFGASCEIVGFGKEDPSDYLYPEQLKMTVVKLV 351
Query: 671 SPERCSAADVHGAAFTPGMLCAGFLEGGTDACQGDSGGPLVCEDETAERQLVLRGIVSWG 850
S C +G+ T MLCA + TD+CQGDSGGPLVC + + +L L GIVSWG
Sbjct: 352 SHRECQQPHYYGSEVTTKMLCAADPQWKTDSCQGDSGGPLVC---STQGRLTLTGIVSWG 408
Query: 851 SGLCDRPQPRVYTDVANYLXXIQEH 925
+ +P VYT V+ +L I H
Sbjct: 409 RECAMKDKPGVYTRVSRFLTWIHTH 433
>ref|NP_999198.1| preproacrosin [Sus scrofa]
Length = 400
Score = 146 bits (368), Expect = 1e-36
Identities = 96/265 (36%), Positives = 130/265 (49%), Gaps = 12/265 (4%)
Frame = +2
Query: 158 CGQRLRKRLSSLNRIVGGLVALPGAHPYIAAL----YWGQ---NFCAGSLIAPCWVLTAA 316
CG R R++L S R+VGG+ A PGA P++ +L Y + C G L+ WVLTAA
Sbjct: 25 CGLRFRQKLESGMRVVGGMSAEPGAWPWMVSLQIFMYHNNRRYHTCGGILLNSHWVLTAA 84
Query: 317 HCLQNRPAPEELTVVLGQDR-----HNQSCEQCQTLAVRSYRLHESYSPKTYQHDLALVR 481
HC +N+ + ++ G + + Q V +HE Y +D+AL++
Sbjct: 85 HCFKNKKKVTDWRLIFGANEVVWGSNKPVKPPLQERFVEEIIIHEKYVSGLEINDIALIK 144
Query: 482 LKETADGCCAHPSPFVQPVCLPRSVASSAEPEGALCEVAGWGHQFEGAEEYSSFLQEAQV 661
+ T C PF+ P CLP+ A C V GWG+ E S LQEA+V
Sbjct: 145 I--TPPVPCG---PFIGPGCLPQFKAGPPRAPQT-CWVTGWGYLKEKGPRTSPTLQEARV 198
Query: 662 PLISPERCSAADVHGAAFTPGMLCAGFLEGGTDACQGDSGGPLVCEDETAERQLVLRGIV 841
LI E C++ + T +CAG+ G D CQGDSGGPL+C D AE V+ GI
Sbjct: 199 ALIDLELCNSTQWYNGRVTSTNVCAGYPRGKIDTCQGDSGGPLMCRDR-AENTFVVVGIT 257
Query: 842 SWGSGLCDRPQPRVYTDVANYLXXI 916
SWG G +P VYT YL I
Sbjct: 258 SWGVGCARAKRPGVYTSTWPYLNWI 282
>ref|NP_001001259.1| enteropeptidase, light chain (L chain) [Sus scrofa]
Length = 1034
Score = 132 bits (332), Expect = 2e-32
Identities = 83/245 (33%), Positives = 132/245 (53%), Gaps = 4/245 (1%)
Frame = +2
Query: 197 RIVGGLVALPGAHPYIAALYW-GQNFCAGSLIAPCWVLTAAHCLQNRPA-PEELTVVLGQ 370
+IVGG + GA P++ ALY+ GQ C SL++ W+++AAHC+ R P + +LG
Sbjct: 799 KIVGGNDSREGAWPWVVALYYNGQLLCGASLVSRDWLVSAAHCVYGRNLEPSKWKAILGL 858
Query: 371 DR-HNQSCEQCQTLAVRSYRLHESYSPKTYQHDLALVRLKETADGCCAHPSPFVQPVCLP 547
N + Q T + ++ Y+ + D+A++ L+ + + ++QP+CLP
Sbjct: 859 HMTSNLTSPQIVTRLIDEIVINPHYNRRRKDSDIAMMHLEFKVNY-----TDYIQPICLP 913
Query: 548 RSVASSAEPEGALCEVAGWGHQ-FEGAEEYSSFLQEAQVPLISPERCSAADVHGAAFTPG 724
+ P G +C +AGWG ++G+ + LQEA VPL+S E+C + T
Sbjct: 914 EE--NQVFPPGRICSIAGWGKVIYQGSP--ADILQEADVPLLSNEKCQQ-QMPEYNITEN 968
Query: 725 MLCAGFLEGGTDACQGDSGGPLVCEDETAERQLVLRGIVSWGSGLCDRPQPRVYTDVANY 904
M+CAG+ EGG D+CQGDSGGPL+C + + +L G+ S+G +P VY V +
Sbjct: 969 MMCAGYEEGGIDSCQGDSGGPLMCLE---NNRWLLAGVTSFGYQCALPNRPGVYARVPKF 1025
Query: 905 LXXIQ 919
IQ
Sbjct: 1026 TEWIQ 1030
>ref|NP_999239.1| kallikrein [Sus scrofa]
Length = 643
Score = 129 bits (323), Expect = 2e-31
Identities = 86/248 (34%), Positives = 122/248 (49%), Gaps = 4/248 (1%)
Frame = +2
Query: 197 RIVGGLVALPGAHPY---IAALYWGQN-FCAGSLIAPCWVLTAAHCLQNRPAPEELTVVL 364
RIVGG + G P+ + A QN C GS+I WVLTAAHC P+ +
Sbjct: 398 RIVGGTDSFLGEWPWQVSLQAKLRAQNHLCGGSIIGHQWVLTAAHCFDGLSLPDIWRIYG 457
Query: 365 GQDRHNQSCEQCQTLAVRSYRLHESYSPKTYQHDLALVRLKETADGCCAHPSPFVQPVCL 544
G ++ ++ V+ +H++Y HD+AL++L+ + + F +P+CL
Sbjct: 458 GILNISEITKETPFSQVKEIIIHQNYKILESGHDIALLKLETPLNY-----TDFQKPICL 512
Query: 545 PRSVASSAEPEGALCEVAGWGHQFEGAEEYSSFLQEAQVPLISPERCSAADVHGAAFTPG 724
P ++ C V GWG E E + LQ+ +PL+S E C + +
Sbjct: 513 PSRDDTNVVYTN--CWVTGWGFTEEKGE-IQNILQKVNIPLVSNEECQKS-YRDHKISKQ 568
Query: 725 MLCAGFLEGGTDACQGDSGGPLVCEDETAERQLVLRGIVSWGSGLCDRPQPRVYTDVANY 904
M+CAG+ EGG DAC+G+SGGPLVC+ L G SWG G R QP VYT V Y
Sbjct: 569 MICAGYKEGGKDACKGESGGPLVCKYNGIWH---LVGTTSWGEGCARREQPGVYTKVIEY 625
Query: 905 LXXIQEHT 928
+ I E T
Sbjct: 626 MDWILEKT 633
>ref|NP_001001911.1| kallikrein 1, renal/pancreas/salivary [Sus scrofa]
Length = 263
Score = 117 bits (293), Expect = 6e-28
Identities = 89/261 (34%), Positives = 122/261 (46%), Gaps = 15/261 (5%)
Frame = +2
Query: 194 NRIVGGLVALPGAHPYIAALYWGQNF-CAGSLIAPCWVLTAAHCLQNRPAPEELTVVLGQ 370
+RI+GG +HP+ A+Y +F C G L+ P WVLTAAHC + V LG+
Sbjct: 23 SRIIGGRECEKDSHPWQVAIYHYSSFQCGGVLVDPKWVLTAAHCKN-----DNYQVWLGR 77
Query: 371 DRHNQSCEQCQTLAVRS-----------YRLHESYSPKTYQHDLALVRLKETADGCCAHP 517
++ Q V + + H K Y HDL L+RL+ A A
Sbjct: 78 HNLFENEVTAQFFGVTADFPHPGFNLSLLKNHTKADGKDYSHDLMLLRLQSPAKITDA-- 135
Query: 518 SPFVQPVCLPRSVASSAEPE-GALCEVAGWGHQFEGAEEYSSFLQEAQ-VPLISPERCSA 691
V+ + LP + EPE G+ C+ +GWG G +++ F E Q V L +
Sbjct: 136 ---VKVLELP-----TQEPELGSTCQASGWGSIEPGPDDFE-FPDEIQCVELTLLQNTFC 186
Query: 692 ADVHGAAFTPGMLCAGFLEGGTDACQGDSGGPLVCEDETAERQLVLRGIVSWGSGLC-DR 868
AD H T MLCAG+L GG D C GDSGGPL+C + +GI SWG C
Sbjct: 187 ADAHPDKVTESMLCAGYLPGGKDTCMGDSGGPLICNG-------MWQGITSWGHTPCGSA 239
Query: 869 PQPRVYTDVANYLXXIQEHTT 931
+P +YT + YL I + T
Sbjct: 240 NKPSIYTKLIFYLDWINDTIT 260
>ref|NP_999356.1| tryptase [Sus scrofa]
Length = 275
Score = 115 bits (289), Expect = 2e-27
Identities = 95/265 (35%), Positives = 125/265 (47%), Gaps = 14/265 (5%)
Frame = +2
Query: 200 IVGGLVALPGAHPYIAAL-----YWGQNFCAGSLIAPCWVLTAAHCLQNRPA-PEELTVV 361
IVGG A P+ +L YW ++FC GSLI P WVLTAAHC A P + V
Sbjct: 31 IVGGKEAPGHKWPWQVSLRCLDQYW-KHFCGGSLIHPQWVLTAAHCFGPEKADPLYIRVQ 89
Query: 362 LGQDRHNQSCEQCQTLAVRSYRLHESYSPKTYQHDLALVRLKETADGCCAHPSPFVQPVC 541
LG+ Q + L V +H +Y + D+AL+ L++ + S VQPV
Sbjct: 90 LGE---QHLYYQDRLLLVSRIIVHPNYYDEVNGADIALLELEDP-----VNLSSHVQPVT 141
Query: 542 LPRSVASSAEPEGALCEVAGWGHQFEGAEEYSSF-LQEAQVPLISPERCSAADVHGAA-- 712
LP AS P+G C V GWG G + L++ +VP++ C G +
Sbjct: 142 LP--PASETFPKGTRCWVTGWGDVHSGWPLPPPYPLKQVRVPIVENSECDMQYHLGLSTG 199
Query: 713 -----FTPGMLCAGFLEGGTDACQGDSGGPLVCEDETAERQLVLRGIVSWGSGLCDRPQP 877
MLCAG G D+CQGDSGGPLVC Q G+VSWG G +P
Sbjct: 200 DNIPIVRDDMLCAG--SEGHDSCQGDSGGPLVCRVNGTWLQ---AGVVSWGEGCALPNRP 254
Query: 878 RVYTDVANYLXXIQEHTTFLTPRDS 952
+YT V +YL I + PR+S
Sbjct: 255 GIYTRVTHYLDWIHQ----CIPRES 275
>ref|NP_998967.1| enamel matrix serine proteinase 1 [Sus scrofa]
Length = 254
Score = 114 bits (284), Expect = 7e-27
Identities = 82/245 (33%), Positives = 115/245 (46%), Gaps = 5/245 (2%)
Frame = +2
Query: 200 IVGGLVALPGAHPYIAALYWGQNF-CAGSLIAPCWVLTAAHCLQNRPAPEELTVVLGQDR 376
I+ G P + P+ AAL+ +F C G L+ P WVL+AAHC QN + +G
Sbjct: 31 IINGEDCNPHSQPWQAALFLEDDFFCGGVLVHPQWVLSAAHCFQN-------SYTIGLGL 83
Query: 377 HNQSCEQ---CQTLAVRSYRLHESYSPKTYQHDLALVRLKETADGCCAHPSPFVQPVCLP 547
HN EQ Q + H Y+ + +DL L++LKE+ S V+ +
Sbjct: 84 HNLEPEQEPGSQMMEASLSIQHPEYNEPSMANDLMLIKLKESVS-----LSDTVRNI--- 135
Query: 548 RSVASSAEPEGALCEVAGWGHQFEGAEEYSSFLQEAQVPLISPERCSAADVHGAAFTPGM 727
SV S G C V+GWG G LQ + + S E C A +G + P M
Sbjct: 136 -SVVSQCPTPGDSCLVSGWGRLASG--RLPQVLQCVNISVASEEVCKAR--YGPVYHPSM 190
Query: 728 LCAGFLEGGTDACQGDSGGPLVCEDETAERQLVLRGIVSWGSGLCDRPQ-PRVYTDVANY 904
CAG + D+C GDSGGPL+C L+G+VS+G C +P P VYT++ +
Sbjct: 191 FCAGGGQDQKDSCHGDSGGPLICNGS-------LQGLVSFGQAQCGQPNVPGVYTNLCKF 243
Query: 905 LXXIQ 919
IQ
Sbjct: 244 TDWIQ 248
>ref|NP_999274.1| pancreatic elastase II [Sus scrofa]
Length = 269
Score = 113 bits (283), Expect = 8e-27
Identities = 93/270 (34%), Positives = 137/270 (50%), Gaps = 12/270 (4%)
Frame = +2
Query: 143 AGLVGCGQRLRKRLSSLNRIVGGLVALPGAHPYIAALYWG-----QNFCAGSLIAPCWVL 307
AG + CG L L L R+VGG A P + P+ +L + ++ C G+L+ WVL
Sbjct: 12 AGALSCG--LPANLPQLPRVVGGEDARPNSWPWQVSLQYDSSGQWRHTCGGTLVDQSWVL 69
Query: 308 TAAHCLQNRPAPEELTVVLGQDRHNQSCEQCQTLAVRSYRL--HESYSPKTYQ--HDLAL 475
TAAHC+ + VVLG RH+ S + +LAV+ +L H+ ++ +D+AL
Sbjct: 70 TAAHCIS---SSRTYRVVLG--RHSLSTNEPGSLAVKVSKLVVHQDWNSNQLSNGNDIAL 124
Query: 476 VRLKETADGCCAHPSPFVQPVCLPRSVASSAEPEGALCEVAGWGH-QFEGAEEYSSFLQE 652
++L + +Q CLP A + P +C V GWG Q GA LQ+
Sbjct: 125 LKLASPVS-----LTDKIQLGCLP--AAGTILPNNYVCYVTGWGRLQTNGAS--PDILQQ 175
Query: 653 AQVPLISPERCSAADVHGAAFTPGMLCAGFLEGGTDACQGDSGGPLVCEDETAERQLVLR 832
Q+ ++ CS G+ M+CAG +G +C GDSGGPL C+ A Q +
Sbjct: 176 GQLLVVDYATCSKPGWWGSTVKTNMICAGG-DGIISSCNGDSGGPLNCQG--ANGQWQVH 232
Query: 833 GIVSWGSGL-CD-RPQPRVYTDVANYLXXI 916
GIVS+GS L C+ +P V+T V+NY+ I
Sbjct: 233 GIVSFGSSLGCNYYHKPSVFTRVSNYIDWI 262
Database: RefSeqSP
Posted date: Aug 1, 2006 7:14 PM
Number of letters in database: 434,620
Number of sequences in database: 1040
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 1,221,392
Number of Sequences: 1040
Number of extensions: 34368
Number of successful extensions: 200
Number of sequences better than 1.0e-05: 10
Number of HSP's better than 0.0 without gapping: 124
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 159
length of database: 434,620
effective HSP length: 79
effective length of database: 352,460
effective search space used: 121951160
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
Search to RefSeqBP
BLASTX 2.2.10 [Oct-19-2004]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= 20060611S-041698
(1279 letters)
Database: RefSeqBP
33,508 sequences; 16,112,626 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
Alignment gi|XP_588610.2| PREDICTED: similar to Coagulation factor XII pr... 502 e-142
Alignment gi|XP_888407.1| PREDICTED: similar to Coagulation factor XII pr... 496 e-140
Alignment gi|XP_875628.1| PREDICTED: similar to Coagulation factor XII pr... 493 e-139
Alignment gi|XP_888406.1| PREDICTED: similar to Coagulation factor XII pr... 482 e-136
Alignment gi|XP_580402.2| PREDICTED: similar to HGF activator preproprote... 241 1e-63
Alignment gi|NP_776571.2| plasminogen activator, tissue [Bos taurus] 169 4e-42
Alignment gi|NP_776572.1| plasminogen activator, urokinase [Bos taurus] 167 2e-41
Alignment gi|XP_618102.2| PREDICTED: similar to Transmembrane protease, s... 162 5e-40
Alignment gi|XP_607216.2| PREDICTED: similar to protease, serine, 33 [Bos... 152 5e-37
Alignment gi|XP_584594.1| PREDICTED: similar to Cationic trypsin III prec... 151 9e-37
>ref|XP_588610.2| PREDICTED: similar to Coagulation factor XII precursor (Hageman
factor) (HAF) isoform 1 [Bos taurus]
Length = 603
Score = 502 bits (1293), Expect = e-142
Identities = 245/313 (78%), Positives = 267/313 (85%), Gaps = 4/313 (1%)
Frame = +2
Query: 2 LTPTQSPSEHQDSPLLS----REPQPTTQTPSQNLTSAWCAPPEQRGPLPSAGLVGCGQR 169
L P Q+ + H+ PL S ++P+ TTQTP +LTS WC+P PL S G GCGQR
Sbjct: 294 LAPCQAAAGHEHFPLPSPSALQKPESTTQTPLPSLTSGWCSPT----PLASGGPGGCGQR 349
Query: 170 LRKRLSSLNRIVGGLVALPGAHPYIAALYWGQNFCAGSLIAPCWVLTAAHCLQNRPAPEE 349
LRK LSSLNR+VGGLVALPGAHPYIAALYW Q+FCAGSLIAPCWVLTAAHCLQNRPAP+E
Sbjct: 350 LRKWLSSLNRVVGGLVALPGAHPYIAALYWDQHFCAGSLIAPCWVLTAAHCLQNRPAPKE 409
Query: 350 LTVVLGQDRHNQSCEQCQTLAVRSYRLHESYSPKTYQHDLALVRLKETADGCCAHPSPFV 529
LTVVLGQDRHNQSCEQCQTLAVR YRLHE++SP TYQHDLALVRL+E+ADGCCAHPSPFV
Sbjct: 410 LTVVLGQDRHNQSCEQCQTLAVRDYRLHEAFSPITYQHDLALVRLQESADGCCAHPSPFV 469
Query: 530 QPVCLPRSVASSAEPEGALCEVAGWGHQFEGAEEYSSFLQEAQVPLISPERCSAADVHGA 709
QPVCLP + A AE E A+CEVAGWGHQFEG EYSSFLQEAQVPLI P+RCSA DVHGA
Sbjct: 470 QPVCLPSTAARPAESEAAVCEVAGWGHQFEGG-EYSSFLQEAQVPLIDPQRCSAPDVHGA 528
Query: 710 AFTPGMLCAGFLEGGTDACQGDSGGPLVCEDETAERQLVLRGIVSWGSGLCDRPQPRVYT 889
AFT GMLCAGFLEGGTDACQGDSGGPLVCEDET ERQL+LRGIVSWGSG +R +P VYT
Sbjct: 529 AFTQGMLCAGFLEGGTDACQGDSGGPLVCEDETPERQLILRGIVSWGSGCGNRLKPGVYT 588
Query: 890 DVANYLXXIQEHT 928
DVANYL I+EHT
Sbjct: 589 DVANYLAWIREHT 601
>ref|XP_888407.1| PREDICTED: similar to Coagulation factor XII precursor (Hageman
factor) (HAF) isoform 4 [Bos taurus]
Length = 610
Score = 496 bits (1276), Expect = e-140
Identities = 245/316 (77%), Positives = 266/316 (84%), Gaps = 7/316 (2%)
Frame = +2
Query: 2 LTPTQSPSEHQDSPLLS----REPQPTTQTPSQNLTSAWCAPPE---QRGPLPSAGLVGC 160
L P Q+ + H+ PL S ++P+ TTQTP +LTS APP PL S G GC
Sbjct: 294 LAPCQAAAGHEHFPLPSPSALQKPESTTQTPLPSLTSGTWAPPTGWCSPTPLASGGPGGC 353
Query: 161 GQRLRKRLSSLNRIVGGLVALPGAHPYIAALYWGQNFCAGSLIAPCWVLTAAHCLQNRPA 340
GQRLRK LSSLNR+VGGLVALPGAHPYIAALYW Q+FCAGSLIAPCWVLTAAHCLQNRPA
Sbjct: 354 GQRLRKWLSSLNRVVGGLVALPGAHPYIAALYWDQHFCAGSLIAPCWVLTAAHCLQNRPA 413
Query: 341 PEELTVVLGQDRHNQSCEQCQTLAVRSYRLHESYSPKTYQHDLALVRLKETADGCCAHPS 520
P+ELTVVLGQDRHNQSCEQCQTLAVR YRLHE++SP TYQHDLALVRL+E+ADGCCAHPS
Sbjct: 414 PKELTVVLGQDRHNQSCEQCQTLAVRDYRLHEAFSPITYQHDLALVRLQESADGCCAHPS 473
Query: 521 PFVQPVCLPRSVASSAEPEGALCEVAGWGHQFEGAEEYSSFLQEAQVPLISPERCSAADV 700
PFVQPVCLP + A AE E A+CEVAGWGHQFEG EYSSFLQEAQVPLI P+RCSA DV
Sbjct: 474 PFVQPVCLPSTAARPAESEAAVCEVAGWGHQFEGG-EYSSFLQEAQVPLIDPQRCSAPDV 532
Query: 701 HGAAFTPGMLCAGFLEGGTDACQGDSGGPLVCEDETAERQLVLRGIVSWGSGLCDRPQPR 880
HGAAFT GMLCAGFLEGGTDACQGDSGGPLVCEDET ERQL+LRGIVSWGSG +R +P
Sbjct: 533 HGAAFTQGMLCAGFLEGGTDACQGDSGGPLVCEDETPERQLILRGIVSWGSGCGNRLKPG 592
Query: 881 VYTDVANYLXXIQEHT 928
VYTDVANYL I+EHT
Sbjct: 593 VYTDVANYLAWIREHT 608
>ref|XP_875628.1| PREDICTED: similar to Coagulation factor XII precursor (Hageman
factor) (HAF) isoform 2 [Bos taurus]
Length = 605
Score = 493 bits (1270), Expect = e-139
Identities = 243/315 (77%), Positives = 265/315 (84%), Gaps = 6/315 (1%)
Frame = +2
Query: 2 LTPTQSPSEHQDSPLLS----REPQPTTQTPSQNLT--SAWCAPPEQRGPLPSAGLVGCG 163
L P Q+ + H+ PL S ++P+ TTQTPS + WC+P PL S G GCG
Sbjct: 294 LAPCQAAAGHEHFPLPSPSALQKPESTTQTPSSAWAPPTGWCSPT----PLASGGPGGCG 349
Query: 164 QRLRKRLSSLNRIVGGLVALPGAHPYIAALYWGQNFCAGSLIAPCWVLTAAHCLQNRPAP 343
QRLRK LSSLNR+VGGLVALPGAHPYIAALYW Q+FCAGSLIAPCWVLTAAHCLQNRPAP
Sbjct: 350 QRLRKWLSSLNRVVGGLVALPGAHPYIAALYWDQHFCAGSLIAPCWVLTAAHCLQNRPAP 409
Query: 344 EELTVVLGQDRHNQSCEQCQTLAVRSYRLHESYSPKTYQHDLALVRLKETADGCCAHPSP 523
+ELTVVLGQDRHNQSCEQCQTLAVR YRLHE++SP TYQHDLALVRL+E+ADGCCAHPSP
Sbjct: 410 KELTVVLGQDRHNQSCEQCQTLAVRDYRLHEAFSPITYQHDLALVRLQESADGCCAHPSP 469
Query: 524 FVQPVCLPRSVASSAEPEGALCEVAGWGHQFEGAEEYSSFLQEAQVPLISPERCSAADVH 703
FVQPVCLP + A AE E A+CEVAGWGHQFEG EYSSFLQEAQVPLI P+RCSA DVH
Sbjct: 470 FVQPVCLPSTAARPAESEAAVCEVAGWGHQFEGG-EYSSFLQEAQVPLIDPQRCSAPDVH 528
Query: 704 GAAFTPGMLCAGFLEGGTDACQGDSGGPLVCEDETAERQLVLRGIVSWGSGLCDRPQPRV 883
GAAFT GMLCAGFLEGGTDACQGDSGGPLVCEDET ERQL+LRGIVSWGSG +R +P V
Sbjct: 529 GAAFTQGMLCAGFLEGGTDACQGDSGGPLVCEDETPERQLILRGIVSWGSGCGNRLKPGV 588
Query: 884 YTDVANYLXXIQEHT 928
YTDVANYL I+EHT
Sbjct: 589 YTDVANYLAWIREHT 603
>ref|XP_888406.1| PREDICTED: similar to Coagulation factor XII precursor (Hageman
factor) (HAF) isoform 3 [Bos taurus]
Length = 593
Score = 482 bits (1240), Expect = e-136
Identities = 240/313 (76%), Positives = 261/313 (83%), Gaps = 4/313 (1%)
Frame = +2
Query: 2 LTPTQSPSEHQDSPLLS----REPQPTTQTPSQNLTSAWCAPPEQRGPLPSAGLVGCGQR 169
L P Q+ + H+ PL S ++P+ TTQTP +LTS S G GCGQR
Sbjct: 294 LAPCQAAAGHEHFPLPSPSALQKPESTTQTPLPSLTSG------------SPG--GCGQR 339
Query: 170 LRKRLSSLNRIVGGLVALPGAHPYIAALYWGQNFCAGSLIAPCWVLTAAHCLQNRPAPEE 349
LRK LSSLNR+VGGLVALPGAHPYIAALYW Q+FCAGSLIAPCWVLTAAHCLQNRPAP+E
Sbjct: 340 LRKWLSSLNRVVGGLVALPGAHPYIAALYWDQHFCAGSLIAPCWVLTAAHCLQNRPAPKE 399
Query: 350 LTVVLGQDRHNQSCEQCQTLAVRSYRLHESYSPKTYQHDLALVRLKETADGCCAHPSPFV 529
LTVVLGQDRHNQSCEQCQTLAVR YRLHE++SP TYQHDLALVRL+E+ADGCCAHPSPFV
Sbjct: 400 LTVVLGQDRHNQSCEQCQTLAVRDYRLHEAFSPITYQHDLALVRLQESADGCCAHPSPFV 459
Query: 530 QPVCLPRSVASSAEPEGALCEVAGWGHQFEGAEEYSSFLQEAQVPLISPERCSAADVHGA 709
QPVCLP + A AE E A+CEVAGWGHQFEG EYSSFLQEAQVPLI P+RCSA DVHGA
Sbjct: 460 QPVCLPSTAARPAESEAAVCEVAGWGHQFEGG-EYSSFLQEAQVPLIDPQRCSAPDVHGA 518
Query: 710 AFTPGMLCAGFLEGGTDACQGDSGGPLVCEDETAERQLVLRGIVSWGSGLCDRPQPRVYT 889
AFT GMLCAGFLEGGTDACQGDSGGPLVCEDET ERQL+LRGIVSWGSG +R +P VYT
Sbjct: 519 AFTQGMLCAGFLEGGTDACQGDSGGPLVCEDETPERQLILRGIVSWGSGCGNRLKPGVYT 578
Query: 890 DVANYLXXIQEHT 928
DVANYL I+EHT
Sbjct: 579 DVANYLAWIREHT 591
>ref|XP_580402.2| PREDICTED: similar to HGF activator preproprotein [Bos taurus]
Length = 577
Score = 241 bits (614), Expect = 1e-63
Identities = 125/270 (46%), Positives = 166/270 (61%), Gaps = 1/270 (0%)
Frame = +2
Query: 116 PEQRGPLPSAGLVGCGQRLRKRLSSLNRIVGGLVALPGAHPYIAALYWGQNFCAGSLIAP 295
P GP AG CG+R +KR RI+GG +LPG+HP++AA+Y G NFCAGSL+
Sbjct: 305 PTAAGP---AGRQTCGKRHKKRTFLRPRIIGGSSSLPGSHPWLAAIYIGNNFCAGSLVHT 361
Query: 296 CWVLTAAHCLQNRPAPEELTVVLGQDRHNQSCEQCQTLAVRSYRLHESYSP-KTYQHDLA 472
CWV++AAHC N P E ++VVLGQ N++ + QT + Y + YS HDL
Sbjct: 362 CWVVSAAHCFSNSPPRESVSVVLGQHFFNRTTDVTQTFGIEKYIPYPLYSVFNPSDHDLV 421
Query: 473 LVRLKETADGCCAHPSPFVQPVCLPRSVASSAEPEGALCEVAGWGHQFEGAEEYSSFLQE 652
L+RL++ + C S FVQP+CLP S+ P G C++AGWGHQ E YS L+E
Sbjct: 422 LIRLEKKGERCAVR-SQFVQPICLPE--PGSSFPPGHKCQIAGWGHQDENVSGYSPSLRE 478
Query: 653 AQVPLISPERCSAADVHGAAFTPGMLCAGFLEGGTDACQGDSGGPLVCEDETAERQLVLR 832
A VPL++ +CS+ +V+GA +P MLCAG+ + +DACQGDSGGPL CE L
Sbjct: 479 ALVPLVADHKCSSPEVYGADISPNMLCAGYFDCRSDACQGDSGGPLACEKNGV---AYLY 535
Query: 833 GIVSWGSGLCDRPQPRVYTDVANYLXXIQE 922
GI+SWG G +P VYT VANY+ I +
Sbjct: 536 GIISWGDGCGRLNKPGVYTRVANYVDWIND 565
>ref|NP_776571.2| plasminogen activator, tissue [Bos taurus]
Length = 566
Score = 169 bits (428), Expect = 4e-42
Identities = 113/294 (38%), Positives = 151/294 (51%), Gaps = 13/294 (4%)
Frame = +2
Query: 86 QNLTSAWCAPPEQRGPLPSAGLVGCGQRLRKRLSSLNRIVGGLVALPGAHPYIAALYW-- 259
+ LT +C P+ V CG R KR RI GGL A +HP+ AA++
Sbjct: 288 RQLTWEYCDVPQ---------CVTCGLRQYKRPQF--RIKGGLFADITSHPWQAAIFVKN 336
Query: 260 ----GQNF-CAGSLIAPCWVLTAAHCLQNRPAPEELTVVLGQDRHNQSCEQCQTLAVRSY 424
G+ F C G LI+ CWVL+AAHC Q R P L V LG+ E+ QT V Y
Sbjct: 337 RRSPGERFLCGGILISSCWVLSAAHCFQERYPPLHLKVFLGRTYRLVPGEEEQTFEVEKY 396
Query: 425 RLHESYSPKTYQHDLALVRLKETADGCCAHPSPFVQPVCLPRSVASSAEPEGALCEVAGW 604
+H+ + TY +D+AL+ LK + CA S V+ +CLP AS P+ CE++G+
Sbjct: 397 IIHKEFDDDTYDNDIALLHLKSDS-LTCARESASVRTICLPD--ASLQLPDWTECELSGY 453
Query: 605 GHQFEGAEEYSSFLQEAQVPLISPERCSAADVHGAAFTPGMLCAGFLEGG------TDAC 766
G + +S L+EA V L RC++ + T MLCAG G DAC
Sbjct: 454 GKHESSSPFFSERLKEAHVRLYPSSRCTSQHLFNRTVTNNMLCAGDTRSGGDHTNLHDAC 513
Query: 767 QGDSGGPLVCEDETAERQLVLRGIVSWGSGLCDRPQPRVYTDVANYLXXIQEHT 928
QGDSGGPLVC + + L GI+SWG G + P VYT V NYL I+++T
Sbjct: 514 QGDSGGPLVC---MKDNHMTLVGIISWGLGCGRKDVPGVYTKVTNYLDWIRDNT 564
>ref|NP_776572.1| plasminogen activator, urokinase [Bos taurus]
Length = 433
Score = 167 bits (423), Expect = 2e-41
Identities = 105/266 (39%), Positives = 138/266 (51%), Gaps = 9/266 (3%)
Frame = +2
Query: 158 CGQR-LRKRLSSLNRIVGGLVALPGAHPYIAALYWGQN------FCAGSLIAPCWVLTAA 316
CGQ+ LR R +IVGG V P+ AA+Y C GSLI+PCWV++A
Sbjct: 170 CGQKALRPRF----KIVGGQVTNAENQPWFAAIYRRHRGGSITYLCGGSLISPCWVVSAT 225
Query: 317 HCLQNRPAPEELTVVLGQDRHNQSCEQCQTLAVRSYRLHESYSPKTYQH--DLALVRLKE 490
HC + P E V LGQ R N V LHE YS ++ H D+AL++++
Sbjct: 226 HCFIDHPKKENYIVYLGQSRLNSDTRGEMQFEVEKLILHEDYSAESLAHHNDIALLKIR- 284
Query: 491 TADGCCAHPSPFVQPVCLPRSVASSAEPEGALCEVAGWGHQFEGAEEYSSFLQEAQVPLI 670
T+ G CA PS +Q +CLP + CE+ G+G + YS L+ V L+
Sbjct: 285 TSRGQCAQPSRSIQTICLPPEHEDAHSR--TRCEITGFGKENPSDYRYSDELKMTFVSLV 342
Query: 671 SPERCSAADVHGAAFTPGMLCAGFLEGGTDACQGDSGGPLVCEDETAERQLVLRGIVSWG 850
S E C +GA T MLCA + TD+CQGDSGGPLVC T + +L L GIVSWG
Sbjct: 343 SHEVCQQPHYYGAEVTDKMLCAADPQWETDSCQGDSGGPLVC---TIQGRLTLTGIVSWG 399
Query: 851 SGLCDRPQPRVYTDVANYLXXIQEHT 928
+ +P VYT V+ +L I HT
Sbjct: 400 RDCAMKYKPGVYTRVSKFLPWINTHT 425
>ref|XP_618102.2| PREDICTED: similar to Transmembrane protease, serine 3 [Bos taurus]
Length = 787
Score = 162 bits (410), Expect = 5e-40
Identities = 107/293 (36%), Positives = 150/293 (51%), Gaps = 5/293 (1%)
Frame = +2
Query: 179 RLSSLNRIVGGLVALPGAHPYIAAL-YWGQNFCAGSLIAPCWVLTAAHCLQNRPAPEELT 355
R S RIVGG + P+ A+L + G + C GS+I P WV+TAAHC+ + P+ T
Sbjct: 244 RTGSSPRIVGGNTSSLAQWPWQASLQFQGYHLCGGSVITPLWVVTAAHCVYDLYLPKSWT 303
Query: 356 VVLGQDRHNQSCEQCQTLAVRSYRLHESYSPKTYQHDLALVRLKETADGCCAHPSPF--- 526
+ +G S + V H Y PK +D+AL++L A P F
Sbjct: 304 IQVGLVSLLDS--PAPSHLVEKIIYHSKYKPKRLGNDIALMKL--------AGPVTFNEM 353
Query: 527 VQPVCLPRSVASSAEPEGALCEVAGWGHQFEGAEEYSSFLQEAQVPLISPERCSAADVHG 706
QPVCLP S + P+G LC +GWG +G + S L A VPLIS + C+ DV+G
Sbjct: 354 TQPVCLPNSEENF--PDGKLCWTSGWGATEDGGDA-SPVLNHAAVPLISNKVCNHRDVYG 410
Query: 707 AAFTPGMLCAGFLEGGTDACQGDSGGPLVCEDETAERQLVLRGIVSWGSGLCDRPQPRVY 886
+P MLCAG+L+GG D+CQGDSGGPLVC++ R L G S+G G + +P VY
Sbjct: 411 GIISPSMLCAGYLKGGVDSCQGDSGGPLVCQE---RRVWKLVGATSFGIGCAEVNKPGVY 467
Query: 887 TDVANYLXXIQEHTTF-LTPRDSSFXPGQFWNGKXAGRDYGQQYCVLSPSAAS 1042
T + ++L I E P+ + G + + + G Q C L P +
Sbjct: 468 TRITSFLDWIHEQMEVGAAPKPPAAHVGAY-HSSSSILSVGPQSCYLEPGGTA 519
>ref|XP_607216.2| PREDICTED: similar to protease, serine, 33 [Bos taurus]
Length = 369
Score = 152 bits (384), Expect = 5e-37
Identities = 117/301 (38%), Positives = 140/301 (46%), Gaps = 13/301 (4%)
Frame = +2
Query: 62 QPTTQTPSQNLTSAWCAPPEQRGPLPSAGLVGCGQRLRKRLSSLNRIVGGLVALPGAHPY 241
QP T Q + P GP CGQ R+SS RIVGG A G P+
Sbjct: 10 QPPCDTAPQACLAGCYGPSSSSGPT-------CGQ---PRVSS--RIVGGRDARAGEWPW 57
Query: 242 IAAL-YWGQNFCAGSLIAPCWVLTAAHCLQNRPAPEELTVVLGQDRHNQSCEQCQTLAVR 418
A++ + G + C GSLIAP WVLTAAHC + P + V LG S VR
Sbjct: 58 QASIQHRGAHVCGGSLIAPQWVLTAAHCFPRKALPADYRVRLGAPHLGPSSPPALLAPVR 117
Query: 419 SYRLHESYSPKTYQHDLALVRLKETADGCCAHPSPF---VQPVCLPRSVASSAEPEGALC 589
L YS DLAL+ L+ P+P VQPVCLP + P G C
Sbjct: 118 RVLLPPDYSEDGAHGDLALLLLR--------RPTPLSTRVQPVCLPE--PGARPPPGTPC 167
Query: 590 EVAGWGHQFEGA--EEYSSFLQEAQVPLISPERCS-----AADVHGA--AFTPGMLCAGF 742
V GWG G E+ LQ +VPL+ C DV A PG LCAG+
Sbjct: 168 WVTGWGSLRPGVPLPEWRP-LQGVRVPLLDAHTCDHLYHLGTDVPRAEHIVLPGSLCAGY 226
Query: 743 LEGGTDACQGDSGGPLVCEDETAERQLVLRGIVSWGSGLCDRPQPRVYTDVANYLXXIQE 922
+ G DACQGDSGGPLVC + +L G+VSWG G +P VYT+VA Y IQ
Sbjct: 227 VGGQKDACQGDSGGPLVC---MKSGRWILVGVVSWGKGCALPNRPGVYTNVATYSPWIQA 283
Query: 923 H 925
H
Sbjct: 284 H 284
>ref|XP_584594.1| PREDICTED: similar to Cationic trypsin III precursor
(Pretrypsinogen III) isoform 1 [Bos taurus]
Length = 246
Score = 151 bits (382), Expect = 9e-37
Identities = 89/243 (36%), Positives = 129/243 (53%)
Frame = +2
Query: 194 NRIVGGLVALPGAHPYIAALYWGQNFCAGSLIAPCWVLTAAHCLQNRPAPEELTVVLGQD 373
++IVGG PY +L G +FC GSLI WV++AAHC ++ + V LG+D
Sbjct: 22 DKIVGGYTCGANTVPYQVSLNSGYHFCGGSLINSQWVVSAAHCYKSG-----IQVRLGED 76
Query: 374 RHNQSCEQCQTLAVRSYRLHESYSPKTYQHDLALVRLKETADGCCAHPSPFVQPVCLPRS 553
N Q ++ +H SY+ T +D+ L++LK A + V + LP S
Sbjct: 77 NINVVEGNEQFISASKSIVHPSYNSNTLNNDIMLIKLKSAAS-----LNSRVASISLPTS 131
Query: 554 VASSAEPEGALCEVAGWGHQFEGAEEYSSFLQEAQVPLISPERCSAADVHGAAFTPGMLC 733
AS+ G C ++GWG+ Y L+ + P++S C +A + T M C
Sbjct: 132 CASA----GTQCLISGWGNTKSSGTSYPDVLKCLKAPILSDSSCKSA--YPGQITSNMFC 185
Query: 734 AGFLEGGTDACQGDSGGPLVCEDETAERQLVLRGIVSWGSGLCDRPQPRVYTDVANYLXX 913
AG+LEGG D+CQGDSGGP+VC + L+GIVSWGSG + +P VYT V NY+
Sbjct: 186 AGYLEGGKDSCQGDSGGPVVCSGK-------LQGIVSWGSGCAQKNKPGVYTKVCNYVSW 238
Query: 914 IQE 922
I++
Sbjct: 239 IKQ 241
Database: RefSeqBP
Posted date: Aug 1, 2006 7:14 PM
Number of letters in database: 16,112,626
Number of sequences in database: 33,508
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 47,257,012
Number of Sequences: 33508
Number of extensions: 1433826
Number of successful extensions: 9605
Number of sequences better than 1.0e-05: 10
Number of HSP's better than 0.0 without gapping: 6146
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 9080
length of database: 16,112,626
effective HSP length: 104
effective length of database: 12,627,794
effective search space used: 4053521874
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
Search to RefSeqHP
BLASTX 2.2.10 [Oct-19-2004]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= 20060611S-041698
(1279 letters)
Database: RefSeqHP
39,411 sequences; 17,774,539 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
Alignment gi|NP_000496.1| coagulation factor XII precursor [Homo sapiens] 437 e-123
Alignment gi|NP_001519.1| HGF activator preproprotein [Homo sapiens] 237 1e-62
Alignment gi|XP_944716.1| PREDICTED: similar to transmembrane protease, s... 171 1e-42
Alignment gi|XP_935021.1| PREDICTED: similar to transmembrane protease, s... 171 1e-42
Alignment gi|NP_127509.1| plasminogen activator, tissue type isoform 3 pr... 167 2e-41
Alignment gi|NP_000921.1| plasminogen activator, tissue type isoform 1 pr... 167 2e-41
Alignment gi|NP_002649.1| urokinase plasminogen activator preproprotein [... 165 9e-41
Alignment gi|NP_115780.1| transmembrane protease, serine 3 isoform 2 [Hom... 165 9e-41
Alignment gi|NP_076927.1| transmembrane protease, serine 3 isoform 1 [Hom... 165 9e-41
Alignment gi|NP_115777.1| transmembrane protease, serine 3 isoform 2 [Hom... 165 9e-41
>ref|NP_000496.1| coagulation factor XII precursor [Homo sapiens]
Length = 615
Score = 437 bits (1124), Expect = e-123
Identities = 220/319 (68%), Positives = 249/319 (78%), Gaps = 11/319 (3%)
Frame = +2
Query: 5 TPTQSPSEHQDSPLLS----------REPQPTTQTPSQNLT-SAWCAPPEQRGPLPSAGL 151
TPTQ+ SP L +PQPTT+TP Q+ T A A EQ L G
Sbjct: 297 TPTQAAPPTPVSPRLHVPLMPAQPAPPKPQPTTRTPPQSQTPGALPAKREQPPSLTRNGP 356
Query: 152 VGCGQRLRKRLSSLNRIVGGLVALPGAHPYIAALYWGQNFCAGSLIAPCWVLTAAHCLQN 331
+ CGQRLRK LSS+ R+VGGLVAL GAHPYIAALYWG +FCAGSLIAPCWVLTAAHCLQ+
Sbjct: 357 LSCGQRLRKSLSSMTRVVGGLVALRGAHPYIAALYWGHSFCAGSLIAPCWVLTAAHCLQD 416
Query: 332 RPAPEELTVVLGQDRHNQSCEQCQTLAVRSYRLHESYSPKTYQHDLALVRLKETADGCCA 511
RPAPE+LTVVLGQ+R N SCE CQTLAVRSYRLHE++SP +YQHDLAL+RL+E ADG CA
Sbjct: 417 RPAPEDLTVVLGQERRNHSCEPCQTLAVRSYRLHEAFSPVSYQHDLALLRLQEDADGSCA 476
Query: 512 HPSPFVQPVCLPRSVASSAEPEGALCEVAGWGHQFEGAEEYSSFLQEAQVPLISPERCSA 691
SP+VQPVCLP A +E LC+VAGWGHQFEGAEEY+SFLQEAQVP +S ERCSA
Sbjct: 477 LLSPYVQPVCLPSGAARPSET--TLCQVAGWGHQFEGAEEYASFLQEAQVPFLSLERCSA 534
Query: 692 ADVHGAAFTPGMLCAGFLEGGTDACQGDSGGPLVCEDETAERQLVLRGIVSWGSGLCDRP 871
DVHG++ PGMLCAGFLEGGTDACQGDSGGPLVCED+ AER+L L+GI+SWGSG DR
Sbjct: 535 PDVHGSSILPGMLCAGFLEGGTDACQGDSGGPLVCEDQAAERRLTLQGIISWGSGCGDRN 594
Query: 872 QPRVYTDVANYLXXIQEHT 928
+P VYTDVA YL I+EHT
Sbjct: 595 KPGVYTDVAYYLAWIREHT 613
>ref|NP_001519.1| HGF activator preproprotein [Homo sapiens]
Length = 655
Score = 237 bits (605), Expect = 1e-62
Identities = 125/273 (45%), Positives = 167/273 (61%), Gaps = 4/273 (1%)
Frame = +2
Query: 116 PEQRGPLP---SAGLVGCGQRLRKRLSSLNRIVGGLVALPGAHPYIAALYWGQNFCAGSL 286
P+ LP S G CG+R +KR RI+GG +LPG+HP++AA+Y G +FCAGSL
Sbjct: 377 PDLLATLPEPASPGRQACGRRHKKRTFLRPRIIGGSSSLPGSHPWLAAIYIGDSFCAGSL 436
Query: 287 IAPCWVLTAAHCLQNRPAPEELTVVLGQDRHNQSCEQCQTLAVRSYRLHESYSP-KTYQH 463
+ CWV++AAHC + P + ++VVLGQ N++ + QT + Y + YS H
Sbjct: 437 VHTCWVVSAAHCFSHSPPRDSVSVVLGQHFFNRTTDVTQTFGIEKYIPYTLYSVFNPSDH 496
Query: 464 DLALVRLKETADGCCAHPSPFVQPVCLPRSVASSAEPEGALCEVAGWGHQFEGAEEYSSF 643
DL L+RLK+ D CA S FVQP+CLP S P G C++AGWGH E YSS
Sbjct: 497 DLVLIRLKKKGDR-CATRSQFVQPICLPE--PGSTFPAGHKCQIAGWGHLDENVSGYSSS 553
Query: 644 LQEAQVPLISPERCSAADVHGAAFTPGMLCAGFLEGGTDACQGDSGGPLVCEDETAERQL 823
L+EA VPL++ +CS+ +V+GA +P MLCAG+ + +DACQGDSGGPL CE
Sbjct: 554 LREALVPLVADHKCSSPEVYGADISPNMLCAGYFDCKSDACQGDSGGPLACEKNGV---A 610
Query: 824 VLRGIVSWGSGLCDRPQPRVYTDVANYLXXIQE 922
L GI+SWG G +P VYT VANY+ I +
Sbjct: 611 YLYGIISWGDGCGRLHKPGVYTRVANYVDWIND 643
>ref|XP_944716.1| PREDICTED: similar to transmembrane protease, serine 9 [Homo
sapiens]
Length = 603
Score = 171 bits (433), Expect = 1e-42
Identities = 109/274 (39%), Positives = 143/274 (52%), Gaps = 8/274 (2%)
Frame = +2
Query: 158 CGQRLRKRLSSLN------RIVGGLVALPGAHPYIAALYWG-QNFCAGSLIAPCWVLTAA 316
CG+R R S+ N RIVGG A PGA P++ L G Q C G L+A WVLTAA
Sbjct: 88 CGER---RPSTANVTRAHGRIVGGSAAPPGAWPWLVRLQLGGQPLCGGVLVAASWVLTAA 144
Query: 317 HCLQNRPAPEELTVVLGQDRHNQSCEQCQTLAVRSYRLHESYSPKTYQHDLALVRLKETA 496
HC P TV L + EQ + + V H + P+T+ +DLALV+L
Sbjct: 145 HCFVGAPNELLWTVTLAEGSRG---EQAEEVPVNRILPHPKFDPRTFHNDLALVQLWTPV 201
Query: 497 DGCCAHPSPFVQPVCLPRSVASSAEPEGALCEVAGWGHQFEGAEEYSSFLQEAQVPLISP 676
P +PVCLP+ P G C +AGWG FE E + ++EA+VPL+S
Sbjct: 202 S-----PGGSARPVCLPQE--PQEPPAGTACAIAGWGALFEDGPEAEA-VREARVPLLST 253
Query: 677 ERCSAADVHGAAFTPG-MLCAGFLEGGTDACQGDSGGPLVCEDETAERQLVLRGIVSWGS 853
+ C A G P MLCAG+L GG D+CQGDSGGPL C + + VL G+ SWG
Sbjct: 254 DTCRRA--LGPGLRPSTMLCAGYLAGGVDSCQGDSGGPLTCSEPGPRPREVLFGVTSWGD 311
Query: 854 GLCDRPQPRVYTDVANYLXXIQEHTTFLTPRDSS 955
G + +P VYT VA + +QE + + R+ S
Sbjct: 312 GCGEPGKPGVYTRVAVFKDWLQEQMSASSSREPS 345
>ref|XP_935021.1| PREDICTED: similar to transmembrane protease, serine 9 [Homo
sapiens]
Length = 603
Score = 171 bits (433), Expect = 1e-42
Identities = 109/274 (39%), Positives = 143/274 (52%), Gaps = 8/274 (2%)
Frame = +2
Query: 158 CGQRLRKRLSSLN------RIVGGLVALPGAHPYIAALYWG-QNFCAGSLIAPCWVLTAA 316
CG+R R S+ N RIVGG A PGA P++ L G Q C G L+A WVLTAA
Sbjct: 88 CGER---RPSTANVTRAHGRIVGGSAAPPGAWPWLVRLQLGGQPLCGGVLVAASWVLTAA 144
Query: 317 HCLQNRPAPEELTVVLGQDRHNQSCEQCQTLAVRSYRLHESYSPKTYQHDLALVRLKETA 496
HC P TV L + EQ + + V H + P+T+ +DLALV+L
Sbjct: 145 HCFVGAPNELLWTVTLAEGSRG---EQAEEVPVNRILPHPKFDPRTFHNDLALVQLWTPV 201
Query: 497 DGCCAHPSPFVQPVCLPRSVASSAEPEGALCEVAGWGHQFEGAEEYSSFLQEAQVPLISP 676
P +PVCLP+ P G C +AGWG FE E + ++EA+VPL+S
Sbjct: 202 S-----PGGSARPVCLPQE--PQEPPAGTACAIAGWGALFEDGPEAEA-VREARVPLLST 253
Query: 677 ERCSAADVHGAAFTPG-MLCAGFLEGGTDACQGDSGGPLVCEDETAERQLVLRGIVSWGS 853
+ C A G P MLCAG+L GG D+CQGDSGGPL C + + VL G+ SWG
Sbjct: 254 DTCRRA--LGPGLRPSTMLCAGYLAGGVDSCQGDSGGPLTCSEPGPRPREVLFGVTSWGD 311
Query: 854 GLCDRPQPRVYTDVANYLXXIQEHTTFLTPRDSS 955
G + +P VYT VA + +QE + + R+ S
Sbjct: 312 GCGEPGKPGVYTRVAVFKDWLQEQMSASSSREPS 345
>ref|NP_127509.1| plasminogen activator, tissue type isoform 3 precursor [Homo sapiens]
Length = 516
Score = 167 bits (423), Expect = 2e-41
Identities = 106/269 (39%), Positives = 145/269 (53%), Gaps = 13/269 (4%)
Frame = +2
Query: 158 CGQRLRKRLSSLNRIVGGLVALPGAHPYIAALYW------GQNF-CAGSLIAPCWVLTAA 316
CG LR+ RI GGL A +HP+ AA++ G+ F C G LI+ CW+L+AA
Sbjct: 253 CG--LRQYSQPQFRIKGGLFADIASHPWQAAIFAKHRRSPGERFLCGGILISSCWILSAA 310
Query: 317 HCLQNRPAPEELTVVLGQDRHNQSCEQCQTLAVRSYRLHESYSPKTYQHDLALVRLKETA 496
HC Q R P LTV+LG+ E+ Q V Y +H+ + TY +D+AL++LK +
Sbjct: 311 HCFQERFPPHHLTVILGRTYRVVPGEEEQKFEVEKYIVHKEFDDDTYDNDIALLQLKSDS 370
Query: 497 DGCCAHPSPFVQPVCLPRSVASSAEPEGALCEVAGWGHQFEGAEEYSSFLQEAQVPLISP 676
CA S V+ VCLP A P+ CE++G+G + YS L+EA V L
Sbjct: 371 SR-CAQESSVVRTVCLP--PADLQLPDWTECELSGYGKHEALSPFYSERLKEAHVRLYPS 427
Query: 677 ERCSAADVHGAAFTPGMLCAGFLEGG------TDACQGDSGGPLVCEDETAERQLVLRGI 838
RC++ + T MLCAG G DACQGDSGGPLVC + + ++ L GI
Sbjct: 428 SRCTSQHLLNRTVTDNMLCAGDTRSGGPQANLHDACQGDSGGPLVCLN---DGRMTLVGI 484
Query: 839 VSWGSGLCDRPQPRVYTDVANYLXXIQEH 925
+SWG G + P VYT V NYL I+++
Sbjct: 485 ISWGLGCGQKDVPGVYTKVTNYLDWIRDN 513
>ref|NP_000921.1| plasminogen activator, tissue type isoform 1 preproprotein [Homo
sapiens]
Length = 562
Score = 167 bits (423), Expect = 2e-41
Identities = 106/269 (39%), Positives = 145/269 (53%), Gaps = 13/269 (4%)
Frame = +2
Query: 158 CGQRLRKRLSSLNRIVGGLVALPGAHPYIAALYW------GQNF-CAGSLIAPCWVLTAA 316
CG LR+ RI GGL A +HP+ AA++ G+ F C G LI+ CW+L+AA
Sbjct: 299 CG--LRQYSQPQFRIKGGLFADIASHPWQAAIFAKHRRSPGERFLCGGILISSCWILSAA 356
Query: 317 HCLQNRPAPEELTVVLGQDRHNQSCEQCQTLAVRSYRLHESYSPKTYQHDLALVRLKETA 496
HC Q R P LTV+LG+ E+ Q V Y +H+ + TY +D+AL++LK +
Sbjct: 357 HCFQERFPPHHLTVILGRTYRVVPGEEEQKFEVEKYIVHKEFDDDTYDNDIALLQLKSDS 416
Query: 497 DGCCAHPSPFVQPVCLPRSVASSAEPEGALCEVAGWGHQFEGAEEYSSFLQEAQVPLISP 676
CA S V+ VCLP A P+ CE++G+G + YS L+EA V L
Sbjct: 417 SR-CAQESSVVRTVCLP--PADLQLPDWTECELSGYGKHEALSPFYSERLKEAHVRLYPS 473
Query: 677 ERCSAADVHGAAFTPGMLCAGFLEGG------TDACQGDSGGPLVCEDETAERQLVLRGI 838
RC++ + T MLCAG G DACQGDSGGPLVC + + ++ L GI
Sbjct: 474 SRCTSQHLLNRTVTDNMLCAGDTRSGGPQANLHDACQGDSGGPLVCLN---DGRMTLVGI 530
Query: 839 VSWGSGLCDRPQPRVYTDVANYLXXIQEH 925
+SWG G + P VYT V NYL I+++
Sbjct: 531 ISWGLGCGQKDVPGVYTKVTNYLDWIRDN 559
>ref|NP_002649.1| urokinase plasminogen activator preproprotein [Homo sapiens]
Length = 431
Score = 165 bits (417), Expect = 9e-41
Identities = 103/284 (36%), Positives = 150/284 (52%), Gaps = 10/284 (3%)
Frame = +2
Query: 107 CAPPEQRGPLPSAGLVGCGQR-LRKRLSSLNRIVGGLVALPGAHPYIAALYWGQN----- 268
CA ++ P CGQ+ LR R +I+GG P+ AA+Y
Sbjct: 151 CADGKKPSSPPEELKFQCGQKTLRPRF----KIIGGEFTTIENQPWFAAIYRRHRGGSVT 206
Query: 269 -FCAGSLIAPCWVLTAAHCLQNRPAPEELTVVLGQDRHNQSCEQCQTLAVRSYRLHESYS 445
C GSLI+PCWV++A HC + P E+ V LG+ R N + + V + LH+ YS
Sbjct: 207 YVCGGSLISPCWVISATHCFIDYPKKEDYIVYLGRSRLNSNTQGEMKFEVENLILHKDYS 266
Query: 446 PKTYQH--DLALVRLKETADGCCAHPSPFVQPVCLPRSVASSAEPE-GALCEVAGWGHQF 616
T H D+AL++++ + +G CA PS +Q +CLP + +P+ G CE+ G+G +
Sbjct: 267 ADTLAHHNDIALLKIR-SKEGRCAQPSRTIQTICLP---SMYNDPQFGTSCEITGFGKEN 322
Query: 617 EGAEEYSSFLQEAQVPLISPERCSAADVHGAAFTPGMLCAGFLEGGTDACQGDSGGPLVC 796
Y L+ V LIS C +G+ T MLCA + TD+CQGDSGGPLVC
Sbjct: 323 STDYLYPEQLKMTVVKLISHRECQQPHYYGSEVTTKMLCAADPQWKTDSCQGDSGGPLVC 382
Query: 797 EDETAERQLVLRGIVSWGSGLCDRPQPRVYTDVANYLXXIQEHT 928
+ + ++ L GIVSWG G + +P VYT V+++L I+ HT
Sbjct: 383 ---SLQGRMTLTGIVSWGRGCALKDKPGVYTRVSHFLPWIRSHT 423
>ref|NP_115780.1| transmembrane protease, serine 3 isoform 2 [Homo sapiens]
Length = 327
Score = 165 bits (417), Expect = 9e-41
Identities = 98/247 (39%), Positives = 139/247 (56%), Gaps = 4/247 (1%)
Frame = +2
Query: 194 NRIVGGLVALPGAHPYIAAL-YWGQNFCAGSLIAPCWVLTAAHCLQNRPAPEELTVVLGQ 370
+RIVGG ++L P+ A+L + G + C GS+I P W++TAAHC+ + P+ T+ +G
Sbjct: 88 SRIVGGNMSLLSQWPWQASLQFQGYHLCGGSVITPLWIITAAHCVYDLYLPKSWTIQVGL 147
Query: 371 DRHNQSCEQCQTLAVRSYRLHESYSPKTYQHDLALVRLKETADGCCAHPSPF---VQPVC 541
+ + V H Y PK +D+AL++L A P F +QPVC
Sbjct: 148 VSLLDN--PAPSHLVEKIVYHSKYKPKRLGNDIALMKL--------AGPLTFNEMIQPVC 197
Query: 542 LPRSVASSAEPEGALCEVAGWGHQFEGAEEYSSFLQEAQVPLISPERCSAADVHGAAFTP 721
LP S + P+G +C +GWG +GA + S L A VPLIS + C+ DV+G +P
Sbjct: 198 LPNSEENF--PDGKVCWTSGWGATEDGAGDASPVLNHAAVPLISNKICNHRDVYGGIISP 255
Query: 722 GMLCAGFLEGGTDACQGDSGGPLVCEDETAERQLVLRGIVSWGSGLCDRPQPRVYTDVAN 901
MLCAG+L GG D+CQGDSGGPLVC++ R L G S+G G + +P VYT V +
Sbjct: 256 SMLCAGYLTGGVDSCQGDSGGPLVCQE---RRLWKLVGATSFGIGCAEVNKPGVYTRVTS 312
Query: 902 YLXXIQE 922
+L I E
Sbjct: 313 FLDWIHE 319
>ref|NP_076927.1| transmembrane protease, serine 3 isoform 1 [Homo sapiens]
Length = 454
Score = 165 bits (417), Expect = 9e-41
Identities = 98/247 (39%), Positives = 139/247 (56%), Gaps = 4/247 (1%)
Frame = +2
Query: 194 NRIVGGLVALPGAHPYIAAL-YWGQNFCAGSLIAPCWVLTAAHCLQNRPAPEELTVVLGQ 370
+RIVGG ++L P+ A+L + G + C GS+I P W++TAAHC+ + P+ T+ +G
Sbjct: 215 SRIVGGNMSLLSQWPWQASLQFQGYHLCGGSVITPLWIITAAHCVYDLYLPKSWTIQVGL 274
Query: 371 DRHNQSCEQCQTLAVRSYRLHESYSPKTYQHDLALVRLKETADGCCAHPSPF---VQPVC 541
+ + V H Y PK +D+AL++L A P F +QPVC
Sbjct: 275 VSLLDN--PAPSHLVEKIVYHSKYKPKRLGNDIALMKL--------AGPLTFNEMIQPVC 324
Query: 542 LPRSVASSAEPEGALCEVAGWGHQFEGAEEYSSFLQEAQVPLISPERCSAADVHGAAFTP 721
LP S + P+G +C +GWG +GA + S L A VPLIS + C+ DV+G +P
Sbjct: 325 LPNSEENF--PDGKVCWTSGWGATEDGAGDASPVLNHAAVPLISNKICNHRDVYGGIISP 382
Query: 722 GMLCAGFLEGGTDACQGDSGGPLVCEDETAERQLVLRGIVSWGSGLCDRPQPRVYTDVAN 901
MLCAG+L GG D+CQGDSGGPLVC++ R L G S+G G + +P VYT V +
Sbjct: 383 SMLCAGYLTGGVDSCQGDSGGPLVCQE---RRLWKLVGATSFGIGCAEVNKPGVYTRVTS 439
Query: 902 YLXXIQE 922
+L I E
Sbjct: 440 FLDWIHE 446
>ref|NP_115777.1| transmembrane protease, serine 3 isoform 2 [Homo sapiens]
Length = 327
Score = 165 bits (417), Expect = 9e-41
Identities = 98/247 (39%), Positives = 139/247 (56%), Gaps = 4/247 (1%)
Frame = +2
Query: 194 NRIVGGLVALPGAHPYIAAL-YWGQNFCAGSLIAPCWVLTAAHCLQNRPAPEELTVVLGQ 370
+RIVGG ++L P+ A+L + G + C GS+I P W++TAAHC+ + P+ T+ +G
Sbjct: 88 SRIVGGNMSLLSQWPWQASLQFQGYHLCGGSVITPLWIITAAHCVYDLYLPKSWTIQVGL 147
Query: 371 DRHNQSCEQCQTLAVRSYRLHESYSPKTYQHDLALVRLKETADGCCAHPSPF---VQPVC 541
+ + V H Y PK +D+AL++L A P F +QPVC
Sbjct: 148 VSLLDN--PAPSHLVEKIVYHSKYKPKRLGNDIALMKL--------AGPLTFNEMIQPVC 197
Query: 542 LPRSVASSAEPEGALCEVAGWGHQFEGAEEYSSFLQEAQVPLISPERCSAADVHGAAFTP 721
LP S + P+G +C +GWG +GA + S L A VPLIS + C+ DV+G +P
Sbjct: 198 LPNSEENF--PDGKVCWTSGWGATEDGAGDASPVLNHAAVPLISNKICNHRDVYGGIISP 255
Query: 722 GMLCAGFLEGGTDACQGDSGGPLVCEDETAERQLVLRGIVSWGSGLCDRPQPRVYTDVAN 901
MLCAG+L GG D+CQGDSGGPLVC++ R L G S+G G + +P VYT V +
Sbjct: 256 SMLCAGYLTGGVDSCQGDSGGPLVCQE---RRLWKLVGATSFGIGCAEVNKPGVYTRVTS 312
Query: 902 YLXXIQE 922
+L I E
Sbjct: 313 FLDWIHE 319
Database: RefSeqHP
Posted date: Aug 2, 2006 12:57 AM
Number of letters in database: 17,774,539
Number of sequences in database: 39,411
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 54,108,312
Number of Sequences: 39411
Number of extensions: 1711558
Number of successful extensions: 12264
Number of sequences better than 1.0e-05: 10
Number of HSP's better than 0.0 without gapping: 7172
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 11644
length of database: 17,774,539
effective HSP length: 105
effective length of database: 13,636,384
effective search space used: 4363642880
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
Search to RefSeqCP
BLASTX 2.2.10 [Oct-19-2004]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= 20060611S-041698
(1279 letters)
Database: RefSeqCP
33,732 sequences; 19,266,565 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
Alignment gi|XP_546206.2| PREDICTED: similar to Coagulation factor XII pr... 456 e-128
Alignment gi|XP_850538.1| PREDICTED: hepatocyte growth factor activator i... 242 6e-64
Alignment gi|XP_861645.1| PREDICTED: hepatocyte growth factor activator i... 242 6e-64
Alignment gi|NP_001026985.1| HGF activator [Canis familiaris] 242 6e-64
Alignment gi|XP_852751.1| PREDICTED: similar to transmembrane protease, s... 173 3e-43
Alignment gi|XP_539955.2| PREDICTED: similar to Tissue-type plasminogen a... 166 3e-41
Alignment gi|XP_853682.1| PREDICTED: similar to Transmembrane protease, s... 164 2e-40
Alignment gi|XP_536394.2| PREDICTED: similar to urokinase plasminogen act... 159 6e-39
Alignment gi|XP_853980.1| PREDICTED: similar to transmembrane protease, s... 152 5e-37
Alignment gi|XP_541697.2| PREDICTED: similar to Serine protease hepsin (T... 149 4e-36
>ref|XP_546206.2| PREDICTED: similar to Coagulation factor XII precursor (Hageman
factor) (HAF) [Canis familiaris]
Length = 611
Score = 456 bits (1173), Expect = e-128
Identities = 228/311 (73%), Positives = 253/311 (81%), Gaps = 2/311 (0%)
Frame = +2
Query: 2 LTPTQSPSEHQDSPLLSREPQPTTQTPSQNLTSAWCAPPEQRGPLPSAGLVGCGQRLRKR 181
L PTQ PS P+ P P+ Q T A A EQ +PS+ CGQRLRKR
Sbjct: 306 LPPTQVPSGRPTLPV----PSPSALQKPQPPTPASSATREQPAAVPSSR---CGQRLRKR 358
Query: 182 LSSLNRIVGGLVALPGAHPYIAALYWGQNFCAGSLIAPCWVLTAAHCLQNRPAPEELTVV 361
LSSL+R+VGGLVALPGAHPYIAALYW +FCAGSLIA CWVLTAAHCLQ+RPAP ELTVV
Sbjct: 359 LSSLSRVVGGLVALPGAHPYIAALYWRHSFCAGSLIASCWVLTAAHCLQDRPAPGELTVV 418
Query: 362 LGQDRHNQSCEQCQTLAVRSYRLHESYSPKTYQHDLALVRLKETADGCCAHPSPFVQPVC 541
LGQDRHN+SCEQCQTLAVR+YRLHES+SP TYQHDLAL+RL+ETADG CA PSPFVQPVC
Sbjct: 419 LGQDRHNRSCEQCQTLAVRAYRLHESFSPVTYQHDLALLRLQETADGRCALPSPFVQPVC 478
Query: 542 LPRSVA--SSAEPEGALCEVAGWGHQFEGAEEYSSFLQEAQVPLISPERCSAADVHGAAF 715
LP A + A+ E ALCEVAGWGH FEGA EYSSFLQEAQVPLI P+RCSA +VHGA+F
Sbjct: 479 LPSGAARPAEAQAEAALCEVAGWGHLFEGAGEYSSFLQEAQVPLIPPQRCSAPEVHGASF 538
Query: 716 TPGMLCAGFLEGGTDACQGDSGGPLVCEDETAERQLVLRGIVSWGSGLCDRPQPRVYTDV 895
PGMLCAGFLEGGTDACQGDSGGPLVCE+E +ERQL+LRGI+SWGSG DR +P VYTDV
Sbjct: 539 IPGMLCAGFLEGGTDACQGDSGGPLVCEEEASERQLILRGIISWGSGCGDRYKPGVYTDV 598
Query: 896 ANYLXXIQEHT 928
A+Y+ IQEHT
Sbjct: 599 ASYVTWIQEHT 609
>ref|XP_850538.1| PREDICTED: hepatocyte growth factor activator isoform 1 [Canis
familiaris]
Length = 654
Score = 242 bits (617), Expect = 6e-64
Identities = 127/268 (47%), Positives = 165/268 (61%), Gaps = 1/268 (0%)
Frame = +2
Query: 122 QRGPLPSAGLVGCGQRLRKRLSSLNRIVGGLVALPGAHPYIAALYWGQNFCAGSLIAPCW 301
Q P P G CG+R +KR RI+GG +LPG+HP++AA+Y G +FCAGSL+ CW
Sbjct: 382 QAEPAP-VGRQTCGKRHKKRTFLRPRIIGGSSSLPGSHPWLAAIYIGDSFCAGSLVHTCW 440
Query: 302 VLTAAHCLQNRPAPEELTVVLGQDRHNQSCEQCQTLAVRSYRLHESYSP-KTYQHDLALV 478
V++AAHC N P E + VVLGQ NQ+ + QT + Y + YS HDL L+
Sbjct: 441 VVSAAHCFSNSPRRESVLVVLGQHFFNQTTDVTQTFGIEKYIPYPMYSVFNPSDHDLVLI 500
Query: 479 RLKETADGCCAHPSPFVQPVCLPRSVASSAEPEGALCEVAGWGHQFEGAEEYSSFLQEAQ 658
RLK+ D C S FVQP+CLP SS P G C++AGWGHQ E YSS L+EA
Sbjct: 501 RLKKKGDRCAIR-SQFVQPICLPEP--SSPFPAGHKCQIAGWGHQDENVSGYSSSLREAL 557
Query: 659 VPLISPERCSAADVHGAAFTPGMLCAGFLEGGTDACQGDSGGPLVCEDETAERQLVLRGI 838
VPL++ +CS+ +V+GA +P MLCAG+ + +DACQGDSGGPL CE L GI
Sbjct: 558 VPLVADHKCSSPEVYGADISPNMLCAGYFDCKSDACQGDSGGPLACEKNGV---AYLYGI 614
Query: 839 VSWGSGLCDRPQPRVYTDVANYLXXIQE 922
+SWG G +P VYT VA Y+ I++
Sbjct: 615 ISWGDGCGRLNKPGVYTRVAKYVDWIKD 642
>ref|XP_861645.1| PREDICTED: hepatocyte growth factor activator isoform 2 [Canis
familiaris]
Length = 657
Score = 242 bits (617), Expect = 6e-64
Identities = 127/268 (47%), Positives = 165/268 (61%), Gaps = 1/268 (0%)
Frame = +2
Query: 122 QRGPLPSAGLVGCGQRLRKRLSSLNRIVGGLVALPGAHPYIAALYWGQNFCAGSLIAPCW 301
Q P P G CG+R +KR RI+GG +LPG+HP++AA+Y G +FCAGSL+ CW
Sbjct: 385 QAEPAP-VGRQTCGKRHKKRTFLRPRIIGGSSSLPGSHPWLAAIYIGDSFCAGSLVHTCW 443
Query: 302 VLTAAHCLQNRPAPEELTVVLGQDRHNQSCEQCQTLAVRSYRLHESYSP-KTYQHDLALV 478
V++AAHC N P E + VVLGQ NQ+ + QT + Y + YS HDL L+
Sbjct: 444 VVSAAHCFSNSPRRESVLVVLGQHFFNQTTDVTQTFGIEKYIPYPMYSVFNPSDHDLVLI 503
Query: 479 RLKETADGCCAHPSPFVQPVCLPRSVASSAEPEGALCEVAGWGHQFEGAEEYSSFLQEAQ 658
RLK+ D C S FVQP+CLP SS P G C++AGWGHQ E YSS L+EA
Sbjct: 504 RLKKKGDRCAIR-SQFVQPICLPEP--SSPFPAGHKCQIAGWGHQDENVSGYSSSLREAL 560
Query: 659 VPLISPERCSAADVHGAAFTPGMLCAGFLEGGTDACQGDSGGPLVCEDETAERQLVLRGI 838
VPL++ +CS+ +V+GA +P MLCAG+ + +DACQGDSGGPL CE L GI
Sbjct: 561 VPLVADHKCSSPEVYGADISPNMLCAGYFDCKSDACQGDSGGPLACEKNGV---AYLYGI 617
Query: 839 VSWGSGLCDRPQPRVYTDVANYLXXIQE 922
+SWG G +P VYT VA Y+ I++
Sbjct: 618 ISWGDGCGRLNKPGVYTRVAKYVDWIKD 645
>ref|NP_001026985.1| HGF activator [Canis familiaris]
Length = 654
Score = 242 bits (617), Expect = 6e-64
Identities = 127/268 (47%), Positives = 165/268 (61%), Gaps = 1/268 (0%)
Frame = +2
Query: 122 QRGPLPSAGLVGCGQRLRKRLSSLNRIVGGLVALPGAHPYIAALYWGQNFCAGSLIAPCW 301
Q P P G CG+R +KR RI+GG +LPG+HP++AA+Y G +FCAGSL+ CW
Sbjct: 382 QAEPAP-VGRQTCGKRHKKRTFLRPRIIGGSSSLPGSHPWLAAIYIGDSFCAGSLVHTCW 440
Query: 302 VLTAAHCLQNRPAPEELTVVLGQDRHNQSCEQCQTLAVRSYRLHESYSP-KTYQHDLALV 478
V++AAHC N P E + VVLGQ NQ+ + QT + Y + YS HDL L+
Sbjct: 441 VVSAAHCFSNSPRRESVLVVLGQHFFNQTTDVTQTFGIEKYIPYPMYSVFNPSDHDLVLI 500
Query: 479 RLKETADGCCAHPSPFVQPVCLPRSVASSAEPEGALCEVAGWGHQFEGAEEYSSFLQEAQ 658
RLK+ D C S FVQP+CLP SS P G C++AGWGHQ E YSS L+EA
Sbjct: 501 RLKKKGDRCAIR-SQFVQPICLPEP--SSPFPAGHKCQIAGWGHQDENVSGYSSSLREAL 557
Query: 659 VPLISPERCSAADVHGAAFTPGMLCAGFLEGGTDACQGDSGGPLVCEDETAERQLVLRGI 838
VPL++ +CS+ +V+GA +P MLCAG+ + +DACQGDSGGPL CE L GI
Sbjct: 558 VPLVADHKCSSPEVYGADISPNMLCAGYFDCKSDACQGDSGGPLACEKNGV---AYLYGI 614
Query: 839 VSWGSGLCDRPQPRVYTDVANYLXXIQE 922
+SWG G +P VYT VA Y+ I++
Sbjct: 615 ISWGDGCGRLNKPGVYTRVAKYVDWIKD 642
>ref|XP_852751.1| PREDICTED: similar to transmembrane protease, serine 9 [Canis
familiaris]
Length = 475
Score = 173 bits (439), Expect = 3e-43
Identities = 112/279 (40%), Positives = 152/279 (54%), Gaps = 11/279 (3%)
Frame = +2
Query: 134 LPSAGLVG-CGQRLRKRLSSLN------RIVGGLVALPGAHPYIAALYWG-QNFCAGSLI 289
LP + L G CG+R R S++N RIVGG A PGA P++ L+ G Q C G L+
Sbjct: 29 LPPSTLQGPCGER---RPSTVNVTRAHGRIVGGSAAPPGAWPWLVRLHLGGQPLCGGVLV 85
Query: 290 APCWVLTAAHCLQNRPAPEELTVVLGQDRHNQSCEQCQTLAVRSYRLHESYSPKTYQHDL 469
A WVLTAAHC P TV L + EQ + + V H + P+T+ +DL
Sbjct: 86 AASWVLTAAHCFAGAPNELLWTVTLAEGPRG---EQAEEVPVNRILPHPKFDPRTFHNDL 142
Query: 470 ALVRLKETADGCCAHPSPFVQPVCLPRSVASSAEPEGALCEVAGWGHQFEGAEEYSSFLQ 649
ALV+L A V+PVCLP+ P G C +AGWG FE E + ++
Sbjct: 143 ALVQLWTPVSRAGA-----VRPVCLPQGPREP--PAGTACAIAGWGALFEDGPEAEA-VR 194
Query: 650 EAQVPLISPERCSAA---DVHGAAFTPGMLCAGFLEGGTDACQGDSGGPLVCEDETAERQ 820
EA+VPL+S + C A ++H ++ MLCAG+L GG D+CQGDSGGPL C + + +
Sbjct: 195 EARVPLLSADTCKRALGPELHPSS----MLCAGYLAGGIDSCQGDSGGPLTCSEPGPQPR 250
Query: 821 LVLRGIVSWGSGLCDRPQPRVYTDVANYLXXIQEHTTFL 937
VL G+ SWG G + +P VYT VA + +QE + L
Sbjct: 251 EVLYGVTSWGDGCGEPGKPGVYTRVAVFRDWLQEQMSEL 289
>ref|XP_539955.2| PREDICTED: similar to Tissue-type plasminogen activator precursor
(tPA) (t-PA) (t-plasminogen activator) [Canis familiaris]
Length = 560
Score = 166 bits (421), Expect = 3e-41
Identities = 104/269 (38%), Positives = 140/269 (52%), Gaps = 13/269 (4%)
Frame = +2
Query: 158 CGQRLRKRLSSLNRIVGGLVALPGAHPYIAALYWGQN-------FCAGSLIAPCWVLTAA 316
CG R K+ RI GGL A +HP+ AA++ FC G LI+ CWVL+AA
Sbjct: 297 CGLRHYKQPQF--RIKGGLYADITSHPWQAAIFVKNRRSPGERFFCGGILISSCWVLSAA 354
Query: 317 HCLQNRPAPEELTVVLGQDRHNQSCEQCQTLAVRSYRLHESYSPKTYQHDLALVRLKETA 496
HC Q R P +L VVLG+ E+ Q V Y H+ + TY +D+AL++L+ +
Sbjct: 355 HCFQERYPPHQLKVVLGRTYREVPGEKEQKFEVEKYITHKEFDDDTYNNDIALLKLQSDS 414
Query: 497 DGCCAHPSPFVQPVCLPRSVASSAEPEGALCEVAGWGHQFEGAEEYSSFLQEAQVPLISP 676
CA S V+ CLP A P+ CE++G+G + YS L+EA V L
Sbjct: 415 LH-CAQESDAVRTACLPE--ADLQLPDWTECELSGYGKHEASSPFYSERLKEAHVRLYPS 471
Query: 677 ERCSAADVHGAAFTPGMLCAGFLEGG------TDACQGDSGGPLVCEDETAERQLVLRGI 838
RC++ + T MLCAG G DACQGDSGGPLVC + ++ L GI
Sbjct: 472 SRCTSRHLFNKTITNNMLCAGDTRSGGNQANLHDACQGDSGGPLVC---MKDNRMTLVGI 528
Query: 839 VSWGSGLCDRPQPRVYTDVANYLXXIQEH 925
+SWG G + P +YT V NYL IQ++
Sbjct: 529 ISWGIGCGQKDVPGIYTKVTNYLDWIQDN 557
>ref|XP_853682.1| PREDICTED: similar to Transmembrane protease, serine 3 (Serine
protease TADG-12) (Tumor associated
differentially-expressed gene-12 protein) [Canis
familiaris]
Length = 513
Score = 164 bits (415), Expect = 2e-40
Identities = 101/252 (40%), Positives = 140/252 (55%), Gaps = 4/252 (1%)
Frame = +2
Query: 179 RLSSLNRIVGGLVALPGAHPYIAAL-YWGQNFCAGSLIAPCWVLTAAHCLQNRPAPEELT 355
R+ +RIVGG + P+ A+L + G + C GS+I P WV+TAAHC+ + P+ T
Sbjct: 208 RMGYSSRIVGGNASSLTQWPWQASLQFQGYHLCGGSVITPVWVVTAAHCVYDLYVPKSWT 267
Query: 356 VVLGQDRHNQSCEQCQTLAVRSYRLHESYSPKTYQHDLALVRLKETADGCCAHPSPF--- 526
V +G S + V H Y PK +D+AL++L A P PF
Sbjct: 268 VQVGLVSLLDS--PAPSHLVEKIIYHSKYKPKRLGNDIALMKL--------AGPVPFNER 317
Query: 527 VQPVCLPRSVASSAEPEGALCEVAGWGHQFEGAEEYSSFLQEAQVPLISPERCSAADVHG 706
+QPVCLP S + P+G +C +GWG +G + S L A VPLIS + C+ DV+G
Sbjct: 318 IQPVCLPNSEENF--PDGKMCWTSGWGATEDGGDA-SPDLNHAAVPLISNKICNHRDVYG 374
Query: 707 AAFTPGMLCAGFLEGGTDACQGDSGGPLVCEDETAERQLVLRGIVSWGSGLCDRPQPRVY 886
+P MLCAG+L+GG D+CQGDSGGPLVC++ R L G S+G G D +P VY
Sbjct: 375 GIISPSMLCAGYLKGGVDSCQGDSGGPLVCQE---RRVWKLVGATSFGIGCADVNKPGVY 431
Query: 887 TDVANYLXXIQE 922
T + ++L I E
Sbjct: 432 TRITSFLDWIHE 443
>ref|XP_536394.2| PREDICTED: similar to urokinase plasminogen activator preproprotein
[Canis familiaris]
Length = 543
Score = 159 bits (402), Expect = 6e-39
Identities = 103/289 (35%), Positives = 144/289 (49%), Gaps = 9/289 (3%)
Frame = +2
Query: 86 QNLTSAWCAPPEQRGPLPSAGLVGCGQR-LRKRLSSLNRIVGGLVALPGAHPYIAALYWG 262
Q T C+ + P CGQ+ LR R +I+GG P+ AA+Y
Sbjct: 256 QECTVQHCSFEKNPHSPPEKAEFQCGQKALRPRF----KIIGGEFTTIENQPWFAAIYRK 311
Query: 263 QNF------CAGSLIAPCWVLTAAHCLQNRPAPEELTVVLGQDRHNQSCEQCQTLAVRSY 424
C GSLI+PCWV++A HC N ++ V LG+ + V
Sbjct: 312 HRGGSVTYQCGGSLISPCWVVSATHCFINSQKKDDYIVYLGRSKRISKTFGEMKFEVEKL 371
Query: 425 RLHESYSPKTYQH--DLALVRLKETADGCCAHPSPFVQPVCLPRSVASSAEPEGALCEVA 598
LHE YS + H D+AL++++ +G CA PS +Q +CLP S + GA CE++
Sbjct: 372 ILHEDYSADSLAHHNDIALLKIRSD-EGQCAQPSRSIQTICLPPSRGDAHF--GASCEIS 428
Query: 599 GWGHQFEGAEEYSSFLQEAQVPLISPERCSAADVHGAAFTPGMLCAGFLEGGTDACQGDS 778
G+G + Y L+ V L+S + C +G+ T MLCA E TD+CQGDS
Sbjct: 429 GFGKENSTDYLYPEQLKMTVVKLVSHQECQQPHYYGSEVTDQMLCAADPEWETDSCQGDS 488
Query: 779 GGPLVCEDETAERQLVLRGIVSWGSGLCDRPQPRVYTDVANYLXXIQEH 925
GGPLVC + + +L L GIVSWGSG + +P VYT V+ +L I H
Sbjct: 489 GGPLVC---STQGRLTLTGIVSWGSGCAMKNKPGVYTRVSRFLPWIHRH 534
>ref|XP_853980.1| PREDICTED: similar to transmembrane protease, serine 5 [Canis
familiaris]
Length = 476
Score = 152 bits (385), Expect = 5e-37
Identities = 93/246 (37%), Positives = 132/246 (53%), Gaps = 3/246 (1%)
Frame = +2
Query: 194 NRIVGGLVALPGAHPYIAALYWG-QNFCAGSLIAPCWVLTAAHCLQNRPA--PEELTVVL 364
+RIVGG PG+ P+ A++ G ++ C GS++AP WV+TAAHC+ + V
Sbjct: 227 SRIVGGQAVAPGSWPWQASVALGSRHTCGGSVLAPRWVVTAAHCMHSFRLFRLSSWRVHA 286
Query: 365 GQDRHNQSCEQCQTLAVRSYRLHESYSPKTYQHDLALVRLKETADGCCAHPSPFVQPVCL 544
G H+ + Q V H YS + + +D+AL+RL+ + S V VCL
Sbjct: 287 GLVSHS-AVRPHQGAVVERIIPHPLYSTQNHDYDIALLRLRTPLNF-----SDTVGAVCL 340
Query: 545 PRSVASSAEPEGALCEVAGWGHQFEGAEEYSSFLQEAQVPLISPERCSAADVHGAAFTPG 724
P P G+ C V+GWGH S LQ+ VPL++ + C+++ ++ A TP
Sbjct: 341 PAEKQDF--PRGSHCWVSGWGHTDPSHTHNSDTLQDTMVPLLNAQLCNSSCMYSGALTPR 398
Query: 725 MLCAGFLEGGTDACQGDSGGPLVCEDETAERQLVLRGIVSWGSGLCDRPQPRVYTDVANY 904
MLCAG+++G DACQGDSGGPLVC D L G+VSWG G + P VY VA +
Sbjct: 399 MLCAGYMDGRADACQGDSGGPLVCPDGDTWH---LVGVVSWGRGCAEPNHPGVYAKVAEF 455
Query: 905 LXXIQE 922
L I +
Sbjct: 456 LDWIHD 461
>ref|XP_541697.2| PREDICTED: similar to Serine protease hepsin (Transmembrane
protease, serine 1) [Canis familiaris]
Length = 417
Score = 149 bits (377), Expect = 4e-36
Identities = 101/255 (39%), Positives = 134/255 (52%), Gaps = 12/255 (4%)
Frame = +2
Query: 176 KRLSSLNRIVGGLVALPGAHPYIAAL-YWGQNFCAGSLIAPCWVLTAAHCLQNRPAPEEL 352
+R ++RIVGG G P+ +L Y G + C GSL++ WVLTAAHC R
Sbjct: 155 RRKLPVDRIVGGQDTSLGRWPWQVSLRYDGAHLCGGSLLSGDWVLTAAHCFPERNRVLSR 214
Query: 353 TVVLGQDRHNQSCEQCQTLAVRSYRLHESYSP------KTYQHDLALVRLKETADGCCAH 514
V S Q L V++ H Y P + +D+ALV L
Sbjct: 215 WRVFAGAVAQASPHGLQ-LGVQAVVYHGGYLPFRDPNSEENSNDIALVHLSS-------- 265
Query: 515 PSP---FVQPVCLPRSVASSAEPEGALCEVAGWGH-QFEGAEEYSSFLQEAQVPLISPER 682
P P ++QPVCLP A A +G +C V GWG+ Q+ G + + LQEA+VP+IS E
Sbjct: 266 PLPLTEYIQPVCLP--AAGQALVDGKICTVTGWGNTQYYGQQ--AGVLQEARVPIISNEL 321
Query: 683 CSAADVHGAAFTPGMLCAGFLEGGTDACQGDSGGPLVCEDETAER-QLVLRGIVSWGSGL 859
C+ D + P M CAG+ EGG DACQGDSGGP VCED + + L GIVSWG+G
Sbjct: 322 CNGPDFYANQIKPKMFCAGYPEGGIDACQGDSGGPFVCEDSISRTPRWRLCGIVSWGTGC 381
Query: 860 CDRPQPRVYTDVANY 904
+P VYT V+++
Sbjct: 382 ALAQKPGVYTKVSDF 396
Database: RefSeqCP
Posted date: Aug 1, 2006 9:25 PM
Number of letters in database: 19,266,565
Number of sequences in database: 33,732
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 55,469,310
Number of Sequences: 33732
Number of extensions: 1690480
Number of successful extensions: 11722
Number of sequences better than 1.0e-05: 10
Number of HSP's better than 0.0 without gapping: 7051
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 11045
length of database: 19,266,565
effective HSP length: 106
effective length of database: 15,690,973
effective search space used: 5005420387
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
Search to RefSeqMP
BLASTX 2.2.10 [Oct-19-2004]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= 20060611S-041698
(1279 letters)
Database: RefSeqMP
45,328 sequences; 21,768,885 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
Alignment gi|NP_067464.1| coagulation factor XII (Hageman factor) [Mus mu... 421 e-118
Alignment gi|NP_062320.1| hepatocyte growth factor activator [Mus musculus] 241 1e-63
Alignment gi|NP_032898.1| plasminogen activator, tissue [Mus musculus] 163 4e-40
Alignment gi|NP_032899.1| plasminogen activator, urokinase [Mus musculus] 163 4e-40
Alignment gi|XP_487606.4| PREDICTED: hypothetical protein LOC69453 [Mus m... 160 2e-39
Alignment gi|NP_542765.1| transmembrane protease, serine 3 [Mus musculus] 158 1e-38
Alignment gi|NP_032307.1| hepsin [Mus musculus] 154 3e-37
Alignment gi|NP_075822.3| trypsinogen 7 [Mus musculus] 152 7e-37
Alignment gi|NP_579929.1| prostasin [Mus musculus] 149 8e-36
Alignment gi|NP_032581.1| mannan-binding lectin serine protease 1 [Mus mu... 148 1e-35
>ref|NP_067464.1| coagulation factor XII (Hageman factor) [Mus musculus]
Length = 597
Score = 421 bits (1082), Expect = e-118
Identities = 206/296 (69%), Positives = 233/296 (78%)
Frame = +2
Query: 38 SPLLSREPQPTTQTPSQNLTSAWCAPPEQRGPLPSAGLVGCGQRLRKRLSSLNRIVGGLV 217
+PL+ E Q + + + +L+ A + + L +GCGQR RK LSS R+VGGLV
Sbjct: 301 APLVVPESQEESPSQAPSLSHAPNDSTDHQTSLSKTNTMGCGQRFRKGLSSFMRVVGGLV 360
Query: 218 ALPGAHPYIAALYWGQNFCAGSLIAPCWVLTAAHCLQNRPAPEELTVVLGQDRHNQSCEQ 397
ALPG+HPYIAALYWG NFCAGSLIAPCWVLTAAHCLQNRPAPEELTVVLGQDRHNQSCE
Sbjct: 361 ALPGSHPYIAALYWGNNFCAGSLIAPCWVLTAAHCLQNRPAPEELTVVLGQDRHNQSCEW 420
Query: 398 CQTLAVRSYRLHESYSPKTYQHDLALVRLKETADGCCAHPSPFVQPVCLPRSVASSAEPE 577
CQTLAVRSYRLHE +S TYQHDLAL+RL+E+ CA SP VQPVCLP A +E
Sbjct: 421 CQTLAVRSYRLHEGFSSITYQHDLALLRLQESKTNSCAILSPHVQPVCLPSGAAPPSET- 479
Query: 578 GALCEVAGWGHQFEGAEEYSSFLQEAQVPLISPERCSAADVHGAAFTPGMLCAGFLEGGT 757
LCEVAGWGHQ EGAEEYS+FLQEAQVP I+ +RCS ++VHG A PGMLCAGFLEGGT
Sbjct: 480 -VLCEVAGWGHQLEGAEEYSTFLQEAQVPFIALDRCSNSNVHGDAILPGMLCAGFLEGGT 538
Query: 758 DACQGDSGGPLVCEDETAERQLVLRGIVSWGSGLCDRPQPRVYTDVANYLXXIQEH 925
DACQGDSGGPLVCE+ TAE QL LRG++SWGSG DR +P VYTDVANYL IQ+H
Sbjct: 539 DACQGDSGGPLVCEEGTAEHQLTLRGVISWGSGCGDRNKPGVYTDVANYLAWIQKH 594
>ref|NP_062320.1| hepatocyte growth factor activator [Mus musculus]
Length = 653
Score = 241 bits (615), Expect = 1e-63
Identities = 127/286 (44%), Positives = 171/286 (59%), Gaps = 4/286 (1%)
Frame = +2
Query: 77 TPSQNLTSAWCAPPEQRGPLPSAGLV---GCGQRLRKRLSSLNRIVGGLVALPGAHPYIA 247
T ++L PE LP + CG+R +KR RI+GG +LPG+HP++A
Sbjct: 362 TACESLARVHSQTPEILAALPESAPAVRPTCGKRHKKRTFLRPRIIGGSSSLPGSHPWLA 421
Query: 248 ALYWGQNFCAGSLIAPCWVLTAAHCLQNRPAPEELTVVLGQDRHNQSCEQCQTLAVRSYR 427
A+Y G +FCAGSL+ CWV++AAHC N P + +TVVLGQ N++ + QT + Y
Sbjct: 422 AIYIGNSFCAGSLVHTCWVVSAAHCFANSPPRDSITVVLGQHFFNRTTDVTQTFGIEKYV 481
Query: 428 LHESYSP-KTYQHDLALVRLKETADGCCAHPSPFVQPVCLPRSVASSAEPEGALCEVAGW 604
+ YS HDL L+RLK+ + C S FVQP+CLP A S+ P G C++AGW
Sbjct: 482 PYTLYSVFNPNNHDLVLIRLKKKGERCAVR-SQFVQPICLPE--AGSSFPTGHKCQIAGW 538
Query: 605 GHQFEGAEEYSSFLQEAQVPLISPERCSAADVHGAAFTPGMLCAGFLEGGTDACQGDSGG 784
GH E YS+ L EA VPL++ +CS+ +V+GA +P MLCAG+ + +DACQGDSGG
Sbjct: 539 GHMDENVSSYSNSLLEALVPLVADHKCSSPEVYGADISPNMLCAGYFDCKSDACQGDSGG 598
Query: 785 PLVCEDETAERQLVLRGIVSWGSGLCDRPQPRVYTDVANYLXXIQE 922
PLVCE L GI+SWG G +P VYT VANY+ I +
Sbjct: 599 PLVCEKNGV---AYLYGIISWGDGCGRLNKPGVYTRVANYVDWIND 641
>ref|NP_032898.1| plasminogen activator, tissue [Mus musculus]
Length = 559
Score = 163 bits (412), Expect = 4e-40
Identities = 104/268 (38%), Positives = 139/268 (51%), Gaps = 12/268 (4%)
Frame = +2
Query: 158 CGQRLRKRLSSLNRIVGGLVALPGAHPYIAALYW------GQNF-CAGSLIAPCWVLTAA 316
CG R KR RI GGL +HP+ AA++ G+ F C G LI+ CWVL+AA
Sbjct: 297 CGLRQYKRPQF--RIKGGLYTDITSHPWQAAIFVKNKRSPGERFLCGGVLISSCWVLSAA 354
Query: 317 HCLQNRPAPEELTVVLGQDRHNQSCEQCQTLAVRSYRLHESYSPKTYQHDLALVRLKETA 496
HC R P L VVLG+ E+ QT + Y +HE + TY +D+AL++L+ +
Sbjct: 355 HCFLERFPPNHLKVVLGRTYRVVPGEEEQTFEIEKYIVHEEFDDDTYDNDIALLQLRSQS 414
Query: 497 DGCCAHPSPFVQPVCLPRSVASSAEPEGALCEVAGWGHQFEGAEEYSSFLQEAQVPLISP 676
CA S V CLP + P+ CE++G+G + +S L+EA V L
Sbjct: 415 KQ-CAQESSSVGTACLPD--PNLQLPDWTECELSGYGKHEASSPFFSDRLKEAHVRLYPS 471
Query: 677 ERCSAADVHGAAFTPGMLCAGFLEGG-----TDACQGDSGGPLVCEDETAERQLVLRGIV 841
RC++ + T MLCAG G DACQGDSGGPLVC +Q+ L GI+
Sbjct: 472 SRCTSQHLFNKTVTNNMLCAGDTRSGGNQDLHDACQGDSGGPLVC---MINKQMTLTGII 528
Query: 842 SWGSGLCDRPQPRVYTDVANYLXXIQEH 925
SWG G + P VYT V NYL I ++
Sbjct: 529 SWGLGCGQKDVPGVYTKVTNYLDWIHDN 556
>ref|NP_032899.1| plasminogen activator, urokinase [Mus musculus]
Length = 433
Score = 163 bits (412), Expect = 4e-40
Identities = 101/266 (37%), Positives = 140/266 (52%), Gaps = 10/266 (3%)
Frame = +2
Query: 158 CGQR-LRKRLSSLNRIVGGLVALPGAHPYIAALYWGQNF-------CAGSLIAPCWVLTA 313
CGQ+ LR R +IVGG P+ AA+Y C GSLI+PCWV +A
Sbjct: 169 CGQKALRPRF----KIVGGEFTEVENQPWFAAIYQKNKGGSPPSFKCGGSLISPCWVASA 224
Query: 314 AHCLQNRPAPEELTVVLGQDRHNQSCEQCQTLAVRSYRLHESYSPKT--YQHDLALVRLK 487
AHC P E V LGQ + + V LHE Y + Y +D+AL++++
Sbjct: 225 AHCFIQLPKKENYVVYLGQSKESSYNPGEMKFEVEQLILHEYYREDSLAYHNDIALLKIR 284
Query: 488 ETADGCCAHPSPFVQPVCLPRSVASSAEPEGALCEVAGWGHQFEGAEEYSSFLQEAQVPL 667
T+ G CA PS +Q +CLP + P G+ CE+ G+G + E Y L+ + V L
Sbjct: 285 -TSTGQCAQPSRSIQTICLPPRFTDA--PFGSDCEITGFGKESESDYLYPKNLKMSVVKL 341
Query: 668 ISPERCSAADVHGAAFTPGMLCAGFLEGGTDACQGDSGGPLVCEDETAERQLVLRGIVSW 847
+S E+C +G+ MLCA E TD+C+GDSGGPL+C E + L GIVSW
Sbjct: 342 VSHEQCMQPHYYGSEINYKMLCAADPEWKTDSCKGDSGGPLIC---NIEGRPTLSGIVSW 398
Query: 848 GSGLCDRPQPRVYTDVANYLXXIQEH 925
G G ++ +P VYT V+++L IQ H
Sbjct: 399 GRGCAEKNKPGVYTRVSHFLDWIQSH 424
>ref|XP_487606.4| PREDICTED: hypothetical protein LOC69453 [Mus musculus]
Length = 586
Score = 160 bits (406), Expect = 2e-39
Identities = 102/262 (38%), Positives = 135/262 (51%), Gaps = 5/262 (1%)
Frame = +2
Query: 152 VGCGQR---LRKRLSSLNRIVGGLVALPGAHPYIAALYWGQ-NFCAGSLIAPCWVLTAAH 319
V CG+R + + RIVGG A GA P++ L G C G L+A WVLTAAH
Sbjct: 72 VQCGERHQGVANTTRAHGRIVGGSTAPSGAWPWLVRLQLGGLPLCGGVLVAASWVLTAAH 131
Query: 320 CLQNRPAPEELTVVLGQDRHNQSCEQCQTLAVRSYRLHESYSPKTYQHDLALVRLKETAD 499
C TV+L + + E+ Q V H + P+T+ +DLALV+L
Sbjct: 132 CFAGASNELLWTVMLAEGPQGEQAEEVQ---VNRILPHPKFDPQTFHNDLALVQLWTPVS 188
Query: 500 GCCAHPSPFVQPVCLPRSVASSAEPEGALCEVAGWGHQFEGAEEYSSFLQEAQVPLISPE 679
P +P+CLP+ S P G C +AGWG FE E S ++EA+VPL+S +
Sbjct: 189 -----PEGPARPICLPQG--SREPPAGTPCAIAGWGALFEDGPE-SEAVREARVPLLSAD 240
Query: 680 RCSAADVHGAAFTPG-MLCAGFLEGGTDACQGDSGGPLVCEDETAERQLVLRGIVSWGSG 856
C V G P MLCAG+L GG D+CQGDSGGPL C + + VL G+ SWG G
Sbjct: 241 TCQK--VLGPGLRPSTMLCAGYLAGGIDSCQGDSGGPLTCSEPGPRPREVLFGVTSWGDG 298
Query: 857 LCDRPQPRVYTDVANYLXXIQE 922
+ +P VYT V + +QE
Sbjct: 299 CGEPGKPGVYTRVTVFKDWLQE 320
>ref|NP_542765.1| transmembrane protease, serine 3 [Mus musculus]
Length = 453
Score = 158 bits (400), Expect = 1e-38
Identities = 96/246 (39%), Positives = 136/246 (55%), Gaps = 4/246 (1%)
Frame = +2
Query: 197 RIVGGLVALPGAHPYIAAL-YWGQNFCAGSLIAPCWVLTAAHCLQNRPAPEELTVVLGQD 373
RIVGG ++ P+ +L + G + C GS+I P W++TAAHC+ + P+ TV +G
Sbjct: 216 RIVGGNMSSLTQWPWQVSLQFQGYHLCGGSIITPLWIVTAAHCVYDLYHPKSWTVQVGLV 275
Query: 374 RHNQSCEQCQTLAVRSYRLHESYSPKTYQHDLALVRLKETADGCCAHPSPF---VQPVCL 544
S + V H Y PK +D+AL++L E P F +QP+CL
Sbjct: 276 SLMDS--PVPSHLVEKIIYHSKYKPKRLGNDIALMKLSE--------PLTFDETIQPICL 325
Query: 545 PRSVASSAEPEGALCEVAGWGHQFEGAEEYSSFLQEAQVPLISPERCSAADVHGAAFTPG 724
P S + P+G LC +GWG +G + S L A VPLIS + C+ DV+G +P
Sbjct: 326 PNSEENF--PDGKLCWTSGWGATEDGGDA-SPVLNHAAVPLISNKICNHRDVYGGIISPS 382
Query: 725 MLCAGFLEGGTDACQGDSGGPLVCEDETAERQLVLRGIVSWGSGLCDRPQPRVYTDVANY 904
MLCAG+L+GG D+CQGDSGGPLVC++ R L G S+G G + +P VYT + ++
Sbjct: 383 MLCAGYLKGGVDSCQGDSGGPLVCQE---RRLWKLVGATSFGIGCAEVNKPGVYTRITSF 439
Query: 905 LXXIQE 922
L I E
Sbjct: 440 LDWIHE 445
>ref|NP_032307.1| hepsin [Mus musculus]
Length = 416
Score = 154 bits (388), Expect = 3e-37
Identities = 106/269 (39%), Positives = 141/269 (52%), Gaps = 9/269 (3%)
Frame = +2
Query: 125 RGPLPSAGLVGCGQRLRKRLSSLNRIVGGLVALPGAHPYIAAL-YWGQNFCAGSLIAPCW 301
RG +A CG +R ++RIVGG + G P+ +L Y G + C GSL++ W
Sbjct: 141 RGRFLTATCQDCG----RRKLPVDRIVGGQDSSLGRWPWQVSLRYDGTHLCGGSLLSGDW 196
Query: 302 VLTAAHCLQNRPAPEELTVVLGQDRHNQSCEQCQTLAVRSYRLHESYSP------KTYQH 463
VLTAAHC R V S Q L V++ H Y P +
Sbjct: 197 VLTAAHCFPERNRVLSRWRVFAGAVARTSPHAVQ-LGVQAVIYHGGYLPFRDPTIDENSN 255
Query: 464 DLALVRLKETADGCCAHPSPFVQPVCLPRSVASSAEPEGALCEVAGWGH-QFEGAEEYSS 640
D+ALV L + + ++QPVCLP A A +G +C V GWG+ QF G + +
Sbjct: 256 DIALVHLSSSLP-----LTEYIQPVCLP--AAGQALVDGKVCTVTGWGNTQFYGQQ--AM 306
Query: 641 FLQEAQVPLISPERCSAADVHGAAFTPGMLCAGFLEGGTDACQGDSGGPLVCEDE-TAER 817
LQEA+VP+IS E C++ D +G P M CAG+ EGG DACQGDSGGP VCED +
Sbjct: 307 VLQEARVPIISNEVCNSPDFYGNQIKPKMFCAGYPEGGIDACQGDSGGPFVCEDSISGTS 366
Query: 818 QLVLRGIVSWGSGLCDRPQPRVYTDVANY 904
+ L GIVSWG+G +P VYT V ++
Sbjct: 367 RWRLCGIVSWGTGCALARKPGVYTKVTDF 395
>ref|NP_075822.3| trypsinogen 7 [Mus musculus]
Length = 247
Score = 152 bits (384), Expect = 7e-37
Identities = 91/243 (37%), Positives = 127/243 (52%)
Frame = +2
Query: 194 NRIVGGLVALPGAHPYIAALYWGQNFCAGSLIAPCWVLTAAHCLQNRPAPEELTVVLGQD 373
++IVGG A PY +L G +FC GSLI WV++AAHC ++R + V LG+
Sbjct: 23 DKIVGGYTCQRNALPYQVSLNSGYHFCGGSLINSQWVVSAAHCYKSR-----IQVRLGEH 77
Query: 374 RHNQSCEQCQTLAVRSYRLHESYSPKTYQHDLALVRLKETADGCCAHPSPFVQPVCLPRS 553
+ Q + H +Y+ TY +D+ L++LK A + V V LPRS
Sbjct: 78 NIDALEGGEQFIDAAKIIRHPNYNANTYNNDIMLIKLKTAAT-----LNSRVSTVALPRS 132
Query: 554 VASSAEPEGALCEVAGWGHQFEGAEEYSSFLQEAQVPLISPERCSAADVHGAAFTPGMLC 733
S+ G C V+GWG+ Y S LQ P++S C+++ + T M C
Sbjct: 133 CPSA----GTRCLVSGWGNTLSSGTNYPSLLQCLDAPVLSDSSCTSS--YPGKITSNMFC 186
Query: 734 AGFLEGGTDACQGDSGGPLVCEDETAERQLVLRGIVSWGSGLCDRPQPRVYTDVANYLXX 913
GFLEGG D+CQGDSGGP+VC + L+G+VSWG G R +P VYT V Y+
Sbjct: 187 LGFLEGGKDSCQGDSGGPVVCNGQ-------LQGVVSWGYGCAQRGKPGVYTKVCKYVNW 239
Query: 914 IQE 922
IQ+
Sbjct: 240 IQQ 242
>ref|NP_579929.1| prostasin [Mus musculus]
Length = 339
Score = 149 bits (375), Expect = 8e-36
Identities = 96/258 (37%), Positives = 125/258 (48%), Gaps = 8/258 (3%)
Frame = +2
Query: 197 RIVGGLVALPGAHPY-IAALYWGQNFCAGSLIAPCWVLTAAHCLQNRPAPEELTVVLGQD 373
RI GG A PG P+ ++ Y G + C GSL++ WV++AAHC + E V LG
Sbjct: 44 RITGGGSAKPGQWPWQVSITYDGNHVCGGSLVSNKWVVSAAHCFPREHSREAYEVKLGAH 103
Query: 374 RHNQSCEQCQTLAVRSYRLHESYSPKTYQHDLALVRLKETADGCCAHPSPFVQPVCLPRS 553
+ + V H SY + Q D+AL+RL S +++P+CLP
Sbjct: 104 QLDSYSNDTVVHTVAQIITHSSYREEGSQGDIALIRLSSPVTF-----SRYIRPICLP-- 156
Query: 554 VASSAEPEGALCEVAGWGHQFEGAE-EYSSFLQEAQVPLISPERCS------AADVHGAA 712
A+++ P G C V GWGH + LQ+ +VPLIS E CS A
Sbjct: 157 AANASFPNGLHCTVTGWGHVAPSVSLQTPRPLQQLEVPLISRETCSCLYNINAVPEEPHT 216
Query: 713 FTPGMLCAGFLEGGTDACQGDSGGPLVCEDETAERQLVLRGIVSWGSGLCDRPQPRVYTD 892
MLCAG+++GG DACQGDSGGPL C E L GIVSWG +P VYT
Sbjct: 217 IQQDMLCAGYVKGGKDACQGDSGGPLSC---PMEGIWYLAGIVSWGDACGAPNRPGVYTL 273
Query: 893 VANYLXXIQEHTTFLTPR 946
+ Y I H L PR
Sbjct: 274 TSTYASWIHHHVAELQPR 291
>ref|NP_032581.1| mannan-binding lectin serine protease 1 [Mus musculus]
Length = 704
Score = 148 bits (373), Expect = 1e-35
Identities = 97/250 (38%), Positives = 132/250 (52%), Gaps = 17/250 (6%)
Frame = +2
Query: 191 LNRIVGGLVALPGAHPYIAALYW--GQNFCAGSLIAPCWVLTAAHCLQNRPAPEELT--- 355
++RI G A G P+IA L GQ FC GSL+ WVLTAAHCL PEE T
Sbjct: 451 ISRIFNGRPAQKGTMPWIAMLSHLNGQPFCGGSLLGSNWVLTAAHCLHQSLDPEEPTLHS 510
Query: 356 ----------VVLGQDRHNQSCEQCQTLAVRSYRLHESYSPKTYQHDLALVRLKETADGC 505
+++G+ +S E Q L V+ LH Y+P T+++DL LV L E+
Sbjct: 511 SYLLSPSDFKIIMGKHWRRRSDEDEQHLHVKRTTLHPLYNPSTFENDLGLVELSESP--- 567
Query: 506 CAHPSPFVQPVCLPRSVASSAEPEGALCEVAGWGHQFEGAEEYSSFLQEAQVPLISPERC 685
+ FV PVCLP ++ EG + V+GWG QF + + L E ++P+++ + C
Sbjct: 568 --RLNDFVMPVCLPEQPST----EGTMVIVSGWGKQF--LQRFPENLMEIEIPIVNSDTC 619
Query: 686 SAADVH-GAAFTPGMLCAGFLEGGTDACQGDSGGPLVCEDETAER-QLVLRGIVSWGSGL 859
A T M+CAG EGG DAC GDSGGP+V +D AER Q L G+VSWG
Sbjct: 620 QEAYTPLKKKVTKDMICAGEKEGGKDACAGDSGGPMVTKD--AERDQWYLVGVVSWGEDC 677
Query: 860 CDRPQPRVYT 889
+ + VY+
Sbjct: 678 GKKDRYGVYS 687
Database: RefSeqMP
Posted date: Aug 2, 2006 12:58 AM
Number of letters in database: 21,768,885
Number of sequences in database: 45,328
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 62,811,206
Number of Sequences: 45328
Number of extensions: 1873146
Number of successful extensions: 12627
Number of sequences better than 1.0e-05: 10
Number of HSP's better than 0.0 without gapping: 7563
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 11829
length of database: 21,768,885
effective HSP length: 106
effective length of database: 16,964,117
effective search space used: 5411553323
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)