Animal-Genome cDNA 20110601C-000625


Search to RefSeqBP_Rel49

BLASTX 2.2.24 [Aug-08-2010]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= 20110601C-000625
         (1129 letters)

Database: RefSeq49_BP.fasta 
           33,088 sequences; 17,681,374 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

Alignment   gi|NP_001029842.1| gamma-secretase subunit APH-1A [Bos taurus].      450   e-126
Alignment   gi|XP_002690889.1| PREDICTED: anterior pharynx defective 1c hom...   255   6e-68
Alignment   gi|XP_871084.1| PREDICTED: presenilin stabilization factor-like...   255   6e-68
Alignment   gi|NP_001178332.1| gamma-secretase subunit APH-1B [Bos taurus].      175   6e-44
Alignment   gi|XP_002690888.1| PREDICTED: anterior pharynx defective 1c hom...   175   6e-44

>ref|NP_001029842.1| gamma-secretase subunit APH-1A [Bos taurus].
          Length = 247

 Score =  450 bits (1157), Expect = e-126
 Identities = 230/247 (93%), Positives = 231/247 (93%)
 Frame = +3

Query: 246 MGAAVFFGCTFVAFGPAFALFLITVAGDPLRVIILVAGXXXXXXXXXXXXXXXXILVHVT 425
           MGAAVFFGCTFVAFGPAFALFLITVAGDPLRVIILVAG                ILVHVT
Sbjct: 1   MGAAVFFGCTFVAFGPAFALFLITVAGDPLRVIILVAGAFFWLVSLLLASVVWFILVHVT 60

Query: 426 DRSDARLQYGLLIFGAAVSVLLQEVFRFAYYKLLKKADEGLASLSEDGRSPISIRQMAYV 605
           DRSDARLQYGLLIFGAAVSVLLQEVFRFAYYKLLKKADEGLASLSEDGRSPISIRQMAYV
Sbjct: 61  DRSDARLQYGLLIFGAAVSVLLQEVFRFAYYKLLKKADEGLASLSEDGRSPISIRQMAYV 120

Query: 606 SGLSFGIISGVFSVINILADALGPGVVGIHGDSPYYFLTSAFLTAAIILLHTFWGVVFFD 785
           SGLSFGIISGVFSVINILADALGPGVVGIHGDSPYYFLTSAFLTAAIILLHTFWGVVFFD
Sbjct: 121 SGLSFGIISGVFSVINILADALGPGVVGIHGDSPYYFLTSAFLTAAIILLHTFWGVVFFD 180

Query: 786 ACERRRYWALGLVVGSHLLTSGLTFLNPWYEASLLPIYAVTVSMGLWAFITAGGSFRSIQ 965
           ACERRRYWALGLVVGSHLLTSGLTFLNPWYEASLLPIYAVT+SMGLWAFITAGGSFRSIQ
Sbjct: 181 ACERRRYWALGLVVGSHLLTSGLTFLNPWYEASLLPIYAVTISMGLWAFITAGGSFRSIQ 240

Query: 966 RSLSCKD 986
           RSLSCKD
Sbjct: 241 RSLSCKD 247


>ref|XP_002690889.1| PREDICTED: anterior pharynx defective 1c homolog isoform 2 [Bos
           taurus].
          Length = 257

 Score =  255 bits (651), Expect = 6e-68
 Identities = 126/247 (51%), Positives = 169/247 (68%)
 Frame = +3

Query: 246 MGAAVFFGCTFVAFGPAFALFLITVAGDPLRVIILVAGXXXXXXXXXXXXXXXXILVHVT 425
           M AAVFFGC F+AFGPA AL++ T+  +PLR+I L+ G                    + 
Sbjct: 1   MTAAVFFGCAFIAFGPALALYIFTIVTEPLRIIFLIIGAFFWLVSLLFSSLIWFTTATLI 60

Query: 426 DRSDARLQYGLLIFGAAVSVLLQEVFRFAYYKLLKKADEGLASLSEDGRSPISIRQMAYV 605
              D   +  LLIFG  +SVL+QE+FRFAYYKLLKKA EGL +++   ++P S+R +AYV
Sbjct: 61  GNKDEPREKYLLIFGVLISVLIQEMFRFAYYKLLKKASEGLKTINPYEKAP-SMRLLAYV 119

Query: 606 SGLSFGIISGVFSVINILADALGPGVVGIHGDSPYYFLTSAFLTAAIILLHTFWGVVFFD 785
           SGL FGI+SGVFS +N L+D+LGPG VGIHGD P +FL SAF+T  I LLH FWG+VFFD
Sbjct: 120 SGLGFGIMSGVFSFVNTLSDSLGPGTVGIHGDPPQFFLYSAFMTLVITLLHVFWGIVFFD 179

Query: 786 ACERRRYWALGLVVGSHLLTSGLTFLNPWYEASLLPIYAVTVSMGLWAFITAGGSFRSIQ 965
            CE+++++ L +V+ SHLL S LT ++P Y  +L+  Y + V MG+WAF  +GGS RS++
Sbjct: 180 GCEKKKWYTLLVVLLSHLLVSALTLISPHYGLNLVLAYIIMVLMGVWAFFVSGGSCRSLK 239

Query: 966 RSLSCKD 986
             L C+D
Sbjct: 240 LCLLCQD 246


>ref|XP_871084.1| PREDICTED: presenilin stabilization factor-like isoform 3 [Bos
           taurus].
          Length = 257

 Score =  255 bits (651), Expect = 6e-68
 Identities = 126/247 (51%), Positives = 169/247 (68%)
 Frame = +3

Query: 246 MGAAVFFGCTFVAFGPAFALFLITVAGDPLRVIILVAGXXXXXXXXXXXXXXXXILVHVT 425
           M AAVFFGC F+AFGPA AL++ T+  +PLR+I L+ G                    + 
Sbjct: 1   MTAAVFFGCAFIAFGPALALYIFTIVTEPLRIIFLIIGAFFWLVSLLFSSLIWFTTATLI 60

Query: 426 DRSDARLQYGLLIFGAAVSVLLQEVFRFAYYKLLKKADEGLASLSEDGRSPISIRQMAYV 605
              D   +  LLIFG  +SVL+QE+FRFAYYKLLKKA EGL +++   ++P S+R +AYV
Sbjct: 61  GNKDEPREKYLLIFGVLISVLIQEMFRFAYYKLLKKASEGLKTINPYEKAP-SMRLLAYV 119

Query: 606 SGLSFGIISGVFSVINILADALGPGVVGIHGDSPYYFLTSAFLTAAIILLHTFWGVVFFD 785
           SGL FGI+SGVFS +N L+D+LGPG VGIHGD P +FL SAF+T  I LLH FWG+VFFD
Sbjct: 120 SGLGFGIMSGVFSFVNTLSDSLGPGTVGIHGDPPQFFLYSAFMTLVITLLHVFWGIVFFD 179

Query: 786 ACERRRYWALGLVVGSHLLTSGLTFLNPWYEASLLPIYAVTVSMGLWAFITAGGSFRSIQ 965
            CE+++++ L +V+ SHLL S LT ++P Y  +L+  Y + V MG+WAF  +GGS RS++
Sbjct: 180 GCEKKKWYTLLVVLLSHLLVSALTLISPHYGLNLVLAYIIMVLMGVWAFFVSGGSCRSLK 239

Query: 966 RSLSCKD 986
             L C+D
Sbjct: 240 LCLLCQD 246


>ref|NP_001178332.1| gamma-secretase subunit APH-1B [Bos taurus].
          Length = 216

 Score =  175 bits (444), Expect = 6e-44
 Identities = 97/247 (39%), Positives = 135/247 (54%)
 Frame = +3

Query: 246 MGAAVFFGCTFVAFGPAFALFLITVAGDPLRVIILVAGXXXXXXXXXXXXXXXXILVHVT 425
           M AAVFFGC F+AFGPA AL++ T+  +PLR+I L+ G                    + 
Sbjct: 1   MTAAVFFGCAFIAFGPALALYIFTIVTEPLRIIFLIIGAFFWLVSLLFSSLIWFTTATLI 60

Query: 426 DRSDARLQYGLLIFGAAVSVLLQEVFRFAYYKLLKKADEGLASLSEDGRSPISIRQMAYV 605
              D   +  LLIFG  +SVL+QE+FRFAYYKLLKKA EGL +++   ++P S+R +AY 
Sbjct: 61  GNKDEPREKYLLIFGVLISVLIQEMFRFAYYKLLKKASEGLKTINPYEKAP-SMRLLAY- 118

Query: 606 SGLSFGIISGVFSVINILADALGPGVVGIHGDSPYYFLTSAFLTAAIILLHTFWGVVFFD 785
                                                   AF+T  I LLH FWG+VFFD
Sbjct: 119 ----------------------------------------AFMTLVITLLHVFWGIVFFD 138

Query: 786 ACERRRYWALGLVVGSHLLTSGLTFLNPWYEASLLPIYAVTVSMGLWAFITAGGSFRSIQ 965
            CE+++++ L +V+ SHLL S LT ++P Y  +L+  Y + V MG+WAF  +GGS RS++
Sbjct: 139 GCEKKKWYTLLVVLLSHLLVSALTLISPHYGLNLVLAYIIMVLMGVWAFFVSGGSCRSLK 198

Query: 966 RSLSCKD 986
             L C+D
Sbjct: 199 LCLLCQD 205


>ref|XP_002690888.1| PREDICTED: anterior pharynx defective 1c homolog isoform 1 [Bos
           taurus].
          Length = 216

 Score =  175 bits (444), Expect = 6e-44
 Identities = 97/247 (39%), Positives = 135/247 (54%)
 Frame = +3

Query: 246 MGAAVFFGCTFVAFGPAFALFLITVAGDPLRVIILVAGXXXXXXXXXXXXXXXXILVHVT 425
           M AAVFFGC F+AFGPA AL++ T+  +PLR+I L+ G                    + 
Sbjct: 1   MTAAVFFGCAFIAFGPALALYIFTIVTEPLRIIFLIIGAFFWLVSLLFSSLIWFTTATLI 60

Query: 426 DRSDARLQYGLLIFGAAVSVLLQEVFRFAYYKLLKKADEGLASLSEDGRSPISIRQMAYV 605
              D   +  LLIFG  +SVL+QE+FRFAYYKLLKKA EGL +++   ++P S+R +AY 
Sbjct: 61  GNKDEPREKYLLIFGVLISVLIQEMFRFAYYKLLKKASEGLKTINPYEKAP-SMRLLAY- 118

Query: 606 SGLSFGIISGVFSVINILADALGPGVVGIHGDSPYYFLTSAFLTAAIILLHTFWGVVFFD 785
                                                   AF+T  I LLH FWG+VFFD
Sbjct: 119 ----------------------------------------AFMTLVITLLHVFWGIVFFD 138

Query: 786 ACERRRYWALGLVVGSHLLTSGLTFLNPWYEASLLPIYAVTVSMGLWAFITAGGSFRSIQ 965
            CE+++++ L +V+ SHLL S LT ++P Y  +L+  Y + V MG+WAF  +GGS RS++
Sbjct: 139 GCEKKKWYTLLVVLLSHLLVSALTLISPHYGLNLVLAYIIMVLMGVWAFFVSGGSCRSLK 198

Query: 966 RSLSCKD 986
             L C+D
Sbjct: 199 LCLLCQD 205


  Database: RefSeq49_BP.fasta
    Posted date:  Oct 17, 2011  1:42 PM
  Number of letters in database: 17,681,374
  Number of sequences in database:  33,088
  
Lambda     K      H
   0.318    0.134    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 33088
Number of Hits to DB: 50,833,464
Number of extensions: 1634054
Number of successful extensions: 7368
Number of sequences better than 1.0e-05: 5
Number of HSP's gapped: 7312
Number of HSP's successfully gapped: 7
Length of query: 376
Length of database: 17,681,374
Length adjustment: 104
Effective length of query: 272
Effective length of database: 14,240,222
Effective search space: 3873340384
Effective search space used: 3873340384
Neighboring words threshold: 12
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 35 (18.1 bits)

Search to RefSeqCP_Rel49

BLASTX 2.2.24 [Aug-08-2010]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= 20110601C-000625
         (1129 letters)

Database: RefSeq49_CP.fasta 
           33,336 sequences; 18,874,504 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

Alignment   gi|XP_860178.1| PREDICTED: similar to anterior pharynx defectiv...   450   e-126
Alignment   gi|XP_860027.1| PREDICTED: similar to anterior pharynx defectiv...   450   e-126
Alignment   gi|XP_540299.1| PREDICTED: similar to Gamma-secretase subunit A...   447   e-125
Alignment   gi|XP_860100.1| PREDICTED: similar to anterior pharynx defectiv...   390   e-109
Alignment   gi|XP_860067.1| PREDICTED: similar to anterior pharynx defectiv...   350   1e-96
Alignment   gi|XP_860136.1| PREDICTED: similar to anterior pharynx defectiv...   327   2e-89
Alignment   gi|XP_859990.1| PREDICTED: similar to Gamma-secretase subunit A...   273   2e-73
Alignment   gi|XP_544714.2| PREDICTED: similar to anterior pharynx defectiv...   221   1e-57

>ref|XP_860178.1| PREDICTED: similar to anterior pharynx defective 1a homolog isoform
           7 [Canis familiaris].
          Length = 247

 Score =  450 bits (1158), Expect = e-126
 Identities = 231/247 (93%), Positives = 231/247 (93%)
 Frame = +3

Query: 246 MGAAVFFGCTFVAFGPAFALFLITVAGDPLRVIILVAGXXXXXXXXXXXXXXXXILVHVT 425
           MGAAVFFGCTFVAFGPAFALFLITVAGDPLRVIILVAG                ILVHVT
Sbjct: 1   MGAAVFFGCTFVAFGPAFALFLITVAGDPLRVIILVAGAFFWLVSLLLASVVWFILVHVT 60

Query: 426 DRSDARLQYGLLIFGAAVSVLLQEVFRFAYYKLLKKADEGLASLSEDGRSPISIRQMAYV 605
           DRSDARLQYGLLIFGAAVSVLLQEVFRFAYYKLLKKADEGLASLSEDGRSPISIRQMAYV
Sbjct: 61  DRSDARLQYGLLIFGAAVSVLLQEVFRFAYYKLLKKADEGLASLSEDGRSPISIRQMAYV 120

Query: 606 SGLSFGIISGVFSVINILADALGPGVVGIHGDSPYYFLTSAFLTAAIILLHTFWGVVFFD 785
           SGLSFGIISGVFSVINILADALGPGVVGIHGDSPYYFLTSAFLTAAIILLHTFWGVVFFD
Sbjct: 121 SGLSFGIISGVFSVINILADALGPGVVGIHGDSPYYFLTSAFLTAAIILLHTFWGVVFFD 180

Query: 786 ACERRRYWALGLVVGSHLLTSGLTFLNPWYEASLLPIYAVTVSMGLWAFITAGGSFRSIQ 965
           ACERRRYWALGLVVGSHLLTSGLTFLNPWYEASLLPIYAVTVSMGLWAFITAGGSFRSIQ
Sbjct: 181 ACERRRYWALGLVVGSHLLTSGLTFLNPWYEASLLPIYAVTVSMGLWAFITAGGSFRSIQ 240

Query: 966 RSLSCKD 986
           RSLSCKD
Sbjct: 241 RSLSCKD 247


>ref|XP_860027.1| PREDICTED: similar to anterior pharynx defective 1a homolog isoform
           3 [Canis familiaris].
          Length = 247

 Score =  450 bits (1158), Expect = e-126
 Identities = 231/247 (93%), Positives = 231/247 (93%)
 Frame = +3

Query: 246 MGAAVFFGCTFVAFGPAFALFLITVAGDPLRVIILVAGXXXXXXXXXXXXXXXXILVHVT 425
           MGAAVFFGCTFVAFGPAFALFLITVAGDPLRVIILVAG                ILVHVT
Sbjct: 1   MGAAVFFGCTFVAFGPAFALFLITVAGDPLRVIILVAGAFFWLVSLLLASVVWFILVHVT 60

Query: 426 DRSDARLQYGLLIFGAAVSVLLQEVFRFAYYKLLKKADEGLASLSEDGRSPISIRQMAYV 605
           DRSDARLQYGLLIFGAAVSVLLQEVFRFAYYKLLKKADEGLASLSEDGRSPISIRQMAYV
Sbjct: 61  DRSDARLQYGLLIFGAAVSVLLQEVFRFAYYKLLKKADEGLASLSEDGRSPISIRQMAYV 120

Query: 606 SGLSFGIISGVFSVINILADALGPGVVGIHGDSPYYFLTSAFLTAAIILLHTFWGVVFFD 785
           SGLSFGIISGVFSVINILADALGPGVVGIHGDSPYYFLTSAFLTAAIILLHTFWGVVFFD
Sbjct: 121 SGLSFGIISGVFSVINILADALGPGVVGIHGDSPYYFLTSAFLTAAIILLHTFWGVVFFD 180

Query: 786 ACERRRYWALGLVVGSHLLTSGLTFLNPWYEASLLPIYAVTVSMGLWAFITAGGSFRSIQ 965
           ACERRRYWALGLVVGSHLLTSGLTFLNPWYEASLLPIYAVTVSMGLWAFITAGGSFRSIQ
Sbjct: 181 ACERRRYWALGLVVGSHLLTSGLTFLNPWYEASLLPIYAVTVSMGLWAFITAGGSFRSIQ 240

Query: 966 RSLSCKD 986
           RSLSCKD
Sbjct: 241 RSLSCKD 247


>ref|XP_540299.1| PREDICTED: similar to Gamma-secretase subunit APH-1A (APH-1a)
           (Aph-1alpha) isoform 1 [Canis familiaris].
          Length = 265

 Score =  447 bits (1149), Expect = e-125
 Identities = 229/246 (93%), Positives = 230/246 (93%)
 Frame = +3

Query: 246 MGAAVFFGCTFVAFGPAFALFLITVAGDPLRVIILVAGXXXXXXXXXXXXXXXXILVHVT 425
           MGAAVFFGCTFVAFGPAFALFLITVAGDPLRVIILVAG                ILVHVT
Sbjct: 1   MGAAVFFGCTFVAFGPAFALFLITVAGDPLRVIILVAGAFFWLVSLLLASVVWFILVHVT 60

Query: 426 DRSDARLQYGLLIFGAAVSVLLQEVFRFAYYKLLKKADEGLASLSEDGRSPISIRQMAYV 605
           DRSDARLQYGLLIFGAAVSVLLQEVFRFAYYKLLKKADEGLASLSEDGRSPISIRQMAYV
Sbjct: 61  DRSDARLQYGLLIFGAAVSVLLQEVFRFAYYKLLKKADEGLASLSEDGRSPISIRQMAYV 120

Query: 606 SGLSFGIISGVFSVINILADALGPGVVGIHGDSPYYFLTSAFLTAAIILLHTFWGVVFFD 785
           SGLSFGIISGVFSVINILADALGPGVVGIHGDSPYYFLTSAFLTAAIILLHTFWGVVFFD
Sbjct: 121 SGLSFGIISGVFSVINILADALGPGVVGIHGDSPYYFLTSAFLTAAIILLHTFWGVVFFD 180

Query: 786 ACERRRYWALGLVVGSHLLTSGLTFLNPWYEASLLPIYAVTVSMGLWAFITAGGSFRSIQ 965
           ACERRRYWALGLVVGSHLLTSGLTFLNPWYEASLLPIYAVTVSMGLWAFITAGGSFRSIQ
Sbjct: 181 ACERRRYWALGLVVGSHLLTSGLTFLNPWYEASLLPIYAVTVSMGLWAFITAGGSFRSIQ 240

Query: 966 RSLSCK 983
           RSLSC+
Sbjct: 241 RSLSCR 246


>ref|XP_860100.1| PREDICTED: similar to anterior pharynx defective 1a homolog isoform
           5 [Canis familiaris].
          Length = 222

 Score =  390 bits (1003), Expect = e-109
 Identities = 206/247 (83%), Positives = 206/247 (83%)
 Frame = +3

Query: 246 MGAAVFFGCTFVAFGPAFALFLITVAGDPLRVIILVAGXXXXXXXXXXXXXXXXILVHVT 425
           MGAAVFFGCTFVAFGPAFALFLITVAGDPLRVIILVAG                ILVHVT
Sbjct: 1   MGAAVFFGCTFVAFGPAFALFLITVAGDPLRVIILVAGAFFWLVSLLLASVVWFILVHVT 60

Query: 426 DRSDARLQYGLLIFGAAVSVLLQEVFRFAYYKLLKKADEGLASLSEDGRSPISIRQMAYV 605
           DRSDARLQYGLLIFGAAVSVLLQEVFRFAYYKLLKKADEGLASLSEDGRSPISIRQMAY 
Sbjct: 61  DRSDARLQYGLLIFGAAVSVLLQEVFRFAYYKLLKKADEGLASLSEDGRSPISIRQMAY- 119

Query: 606 SGLSFGIISGVFSVINILADALGPGVVGIHGDSPYYFLTSAFLTAAIILLHTFWGVVFFD 785
                                   GVVGIHGDSPYYFLTSAFLTAAIILLHTFWGVVFFD
Sbjct: 120 ------------------------GVVGIHGDSPYYFLTSAFLTAAIILLHTFWGVVFFD 155

Query: 786 ACERRRYWALGLVVGSHLLTSGLTFLNPWYEASLLPIYAVTVSMGLWAFITAGGSFRSIQ 965
           ACERRRYWALGLVVGSHLLTSGLTFLNPWYEASLLPIYAVTVSMGLWAFITAGGSFRSIQ
Sbjct: 156 ACERRRYWALGLVVGSHLLTSGLTFLNPWYEASLLPIYAVTVSMGLWAFITAGGSFRSIQ 215

Query: 966 RSLSCKD 986
           RSLSCKD
Sbjct: 216 RSLSCKD 222


>ref|XP_860067.1| PREDICTED: similar to anterior pharynx defective 1a homolog isoform
           4 [Canis familiaris].
          Length = 206

 Score =  350 bits (899), Expect = 1e-96
 Identities = 190/247 (76%), Positives = 190/247 (76%)
 Frame = +3

Query: 246 MGAAVFFGCTFVAFGPAFALFLITVAGDPLRVIILVAGXXXXXXXXXXXXXXXXILVHVT 425
           MGAAVFFGCTFVAFGPAFALFLITVAGDPLRVIILVAG                ILVHVT
Sbjct: 1   MGAAVFFGCTFVAFGPAFALFLITVAGDPLRVIILVAGAFFWLVSLLLASVVWFILVHVT 60

Query: 426 DRSDARLQYGLLIFGAAVSVLLQEVFRFAYYKLLKKADEGLASLSEDGRSPISIRQMAYV 605
           DRSDARLQYGLLIFGAAVSVLLQEVFRFAYYKLLKKADEGLASLSEDGRSPISIRQMAY 
Sbjct: 61  DRSDARLQYGLLIFGAAVSVLLQEVFRFAYYKLLKKADEGLASLSEDGRSPISIRQMAY- 119

Query: 606 SGLSFGIISGVFSVINILADALGPGVVGIHGDSPYYFLTSAFLTAAIILLHTFWGVVFFD 785
                                                   AFLTAAIILLHTFWGVVFFD
Sbjct: 120 ----------------------------------------AFLTAAIILLHTFWGVVFFD 139

Query: 786 ACERRRYWALGLVVGSHLLTSGLTFLNPWYEASLLPIYAVTVSMGLWAFITAGGSFRSIQ 965
           ACERRRYWALGLVVGSHLLTSGLTFLNPWYEASLLPIYAVTVSMGLWAFITAGGSFRSIQ
Sbjct: 140 ACERRRYWALGLVVGSHLLTSGLTFLNPWYEASLLPIYAVTVSMGLWAFITAGGSFRSIQ 199

Query: 966 RSLSCKD 986
           RSLSCKD
Sbjct: 200 RSLSCKD 206


>ref|XP_860136.1| PREDICTED: similar to anterior pharynx defective 1a homolog isoform
           6 [Canis familiaris].
          Length = 190

 Score =  327 bits (837), Expect = 2e-89
 Identities = 181/247 (73%), Positives = 184/247 (74%)
 Frame = +3

Query: 246 MGAAVFFGCTFVAFGPAFALFLITVAGDPLRVIILVAGXXXXXXXXXXXXXXXXILVHVT 425
           MGAAVFFGCTFVAFGPAFALFL           I VAG                      
Sbjct: 1   MGAAVFFGCTFVAFGPAFALFL-----------ITVAGDP-------------------- 29

Query: 426 DRSDARLQYGLLIFGAAVSVLLQEVFRFAYYKLLKKADEGLASLSEDGRSPISIRQMAYV 605
                 L+  +L+ G                    KADEGLASLSEDGRSPISIRQMAYV
Sbjct: 30  ------LRVIILVAG--------------------KADEGLASLSEDGRSPISIRQMAYV 63

Query: 606 SGLSFGIISGVFSVINILADALGPGVVGIHGDSPYYFLTSAFLTAAIILLHTFWGVVFFD 785
           SGLSFGIISGVFSVINILADALGPGVVGIHGDSPYYFLTSAFLTAAIILLHTFWGVVFFD
Sbjct: 64  SGLSFGIISGVFSVINILADALGPGVVGIHGDSPYYFLTSAFLTAAIILLHTFWGVVFFD 123

Query: 786 ACERRRYWALGLVVGSHLLTSGLTFLNPWYEASLLPIYAVTVSMGLWAFITAGGSFRSIQ 965
           ACERRRYWALGLVVGSHLLTSGLTFLNPWYEASLLPIYAVTVSMGLWAFITAGGSFRSIQ
Sbjct: 124 ACERRRYWALGLVVGSHLLTSGLTFLNPWYEASLLPIYAVTVSMGLWAFITAGGSFRSIQ 183

Query: 966 RSLSCKD 986
           RSLSCKD
Sbjct: 184 RSLSCKD 190


>ref|XP_859990.1| PREDICTED: similar to Gamma-secretase subunit APH-1A (APH-1a)
           (Aph-1alpha) (Presenilin stabilization factor) isoform 2
           [Canis familiaris].
          Length = 213

 Score =  273 bits (699), Expect = 2e-73
 Identities = 144/160 (90%), Positives = 144/160 (90%)
 Frame = +3

Query: 246 MGAAVFFGCTFVAFGPAFALFLITVAGDPLRVIILVAGXXXXXXXXXXXXXXXXILVHVT 425
           MGAAVFFGCTFVAFGPAFALFLITVAGDPLRVIILVAG                ILVHVT
Sbjct: 1   MGAAVFFGCTFVAFGPAFALFLITVAGDPLRVIILVAGAFFWLVSLLLASVVWFILVHVT 60

Query: 426 DRSDARLQYGLLIFGAAVSVLLQEVFRFAYYKLLKKADEGLASLSEDGRSPISIRQMAYV 605
           DRSDARLQYGLLIFGAAVSVLLQEVFRFAYYKLLKKADEGLASLSEDGRSPISIRQMAYV
Sbjct: 61  DRSDARLQYGLLIFGAAVSVLLQEVFRFAYYKLLKKADEGLASLSEDGRSPISIRQMAYV 120

Query: 606 SGLSFGIISGVFSVINILADALGPGVVGIHGDSPYYFLTS 725
           SGLSFGIISGVFSVINILADALGPGVVGIHGDSPYYFLTS
Sbjct: 121 SGLSFGIISGVFSVINILADALGPGVVGIHGDSPYYFLTS 160


>ref|XP_544714.2| PREDICTED: similar to anterior pharynx defective 1b homolog [Canis
           familiaris].
          Length = 346

 Score =  221 bits (563), Expect = 1e-57
 Identities = 106/189 (56%), Positives = 142/189 (75%)
 Frame = +3

Query: 420 VTDRSDARLQYGLLIFGAAVSVLLQEVFRFAYYKLLKKADEGLASLSEDGRSPISIRQMA 599
           +T   D  +Q  LLI G  VSVL+QE+FRF YYKLLKKA EGL S++ D  +P S+R +A
Sbjct: 148 ITANKDGPIQKYLLILGVLVSVLIQELFRFVYYKLLKKASEGLKSINPDETTP-SMRLLA 206

Query: 600 YVSGLSFGIISGVFSVINILADALGPGVVGIHGDSPYYFLTSAFLTAAIILLHTFWGVVF 779
           YVSGL FGI+SGVF+ +N L+D+LGPG VGIHGDSP +FL SAF+T  IILLH FWG++F
Sbjct: 207 YVSGLGFGIMSGVFAFVNTLSDSLGPGTVGIHGDSPQFFLNSAFMTLVIILLHVFWGIIF 266

Query: 780 FDACERRRYWALGLVVGSHLLTSGLTFLNPWYEASLLPIYAVTVSMGLWAFITAGGSFRS 959
           FD CE++++ AL +V+ +HLL S LTF++P Y  +L+  Y + + MG+WAF  AGGS R+
Sbjct: 267 FDGCEKKKWSALLIVLLTHLLVSALTFISPHYGINLVSTYMIMLLMGIWAFFVAGGSCRN 326

Query: 960 IQRSLSCKD 986
           ++  L C+D
Sbjct: 327 LKLCLLCQD 335


  Database: RefSeq49_CP.fasta
    Posted date:  Oct 17, 2011  1:42 PM
  Number of letters in database: 18,874,504
  Number of sequences in database:  33,336
  
Lambda     K      H
   0.318    0.134    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 33336
Number of Hits to DB: 53,077,235
Number of extensions: 1690816
Number of successful extensions: 7967
Number of sequences better than 1.0e-05: 8
Number of HSP's gapped: 7924
Number of HSP's successfully gapped: 10
Length of query: 376
Length of database: 18,874,504
Length adjustment: 104
Effective length of query: 272
Effective length of database: 15,407,560
Effective search space: 4190856320
Effective search space used: 4190856320
Neighboring words threshold: 12
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 35 (18.1 bits)

Search to RefSeqHP_Rel49

BLASTX 2.2.24 [Aug-08-2010]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= 20110601C-000625
         (1129 letters)

Database: RefSeq49_HP.fasta 
           32,964 sequences; 18,297,164 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

Alignment   gi|NP_057106.2| gamma-secretase subunit APH-1A isoform 2 [Homo ...   446   e-125
Alignment   gi|NP_001071096.1| gamma-secretase subunit APH-1A isoform 1 [Ho...   442   e-124
Alignment   gi|NP_001230700.1| gamma-secretase subunit APH-1A isoform 3 [Ho...   322   4e-88
Alignment   gi|NP_112591.2| gamma-secretase subunit APH-1B isoform 1 [Homo ...   262   4e-70
Alignment   gi|NP_001230701.1| gamma-secretase subunit APH-1A isoform 4 [Ho...   252   8e-69
Alignment   gi|NP_001139118.1| gamma-secretase subunit APH-1B isoform 2 [Ho...   181   1e-45

>ref|NP_057106.2| gamma-secretase subunit APH-1A isoform 2 [Homo sapiens].
          Length = 247

 Score =  446 bits (1146), Expect = e-125
 Identities = 229/247 (92%), Positives = 229/247 (92%)
 Frame = +3

Query: 246 MGAAVFFGCTFVAFGPAFALFLITVAGDPLRVIILVAGXXXXXXXXXXXXXXXXILVHVT 425
           MGAAVFFGCTFVAFGPAFALFLITVAGDPLRVIILVAG                ILVHVT
Sbjct: 1   MGAAVFFGCTFVAFGPAFALFLITVAGDPLRVIILVAGAFFWLVSLLLASVVWFILVHVT 60

Query: 426 DRSDARLQYGLLIFGAAVSVLLQEVFRFAYYKLLKKADEGLASLSEDGRSPISIRQMAYV 605
           DRSDARLQYGLLIFGAAVSVLLQEVFRFAYYKLLKKADEGLASLSEDGRSPISIRQMAYV
Sbjct: 61  DRSDARLQYGLLIFGAAVSVLLQEVFRFAYYKLLKKADEGLASLSEDGRSPISIRQMAYV 120

Query: 606 SGLSFGIISGVFSVINILADALGPGVVGIHGDSPYYFLTSAFLTAAIILLHTFWGVVFFD 785
           SGLSFGIISGVFSVINILADALGPGVVGIHGDSPYYFLTSAFLTAAIILLHTFWGVVFFD
Sbjct: 121 SGLSFGIISGVFSVINILADALGPGVVGIHGDSPYYFLTSAFLTAAIILLHTFWGVVFFD 180

Query: 786 ACERRRYWALGLVVGSHLLTSGLTFLNPWYEASLLPIYAVTVSMGLWAFITAGGSFRSIQ 965
           ACERRRYWALGLVVGSHLLTSGLTFLNPWYEASLLPIYAVTVSMGLWAFITAGGS RSIQ
Sbjct: 181 ACERRRYWALGLVVGSHLLTSGLTFLNPWYEASLLPIYAVTVSMGLWAFITAGGSLRSIQ 240

Query: 966 RSLSCKD 986
           RSL CKD
Sbjct: 241 RSLLCKD 247


>ref|NP_001071096.1| gamma-secretase subunit APH-1A isoform 1 [Homo sapiens].
          Length = 265

 Score =  442 bits (1137), Expect = e-124
 Identities = 227/246 (92%), Positives = 228/246 (92%)
 Frame = +3

Query: 246 MGAAVFFGCTFVAFGPAFALFLITVAGDPLRVIILVAGXXXXXXXXXXXXXXXXILVHVT 425
           MGAAVFFGCTFVAFGPAFALFLITVAGDPLRVIILVAG                ILVHVT
Sbjct: 1   MGAAVFFGCTFVAFGPAFALFLITVAGDPLRVIILVAGAFFWLVSLLLASVVWFILVHVT 60

Query: 426 DRSDARLQYGLLIFGAAVSVLLQEVFRFAYYKLLKKADEGLASLSEDGRSPISIRQMAYV 605
           DRSDARLQYGLLIFGAAVSVLLQEVFRFAYYKLLKKADEGLASLSEDGRSPISIRQMAYV
Sbjct: 61  DRSDARLQYGLLIFGAAVSVLLQEVFRFAYYKLLKKADEGLASLSEDGRSPISIRQMAYV 120

Query: 606 SGLSFGIISGVFSVINILADALGPGVVGIHGDSPYYFLTSAFLTAAIILLHTFWGVVFFD 785
           SGLSFGIISGVFSVINILADALGPGVVGIHGDSPYYFLTSAFLTAAIILLHTFWGVVFFD
Sbjct: 121 SGLSFGIISGVFSVINILADALGPGVVGIHGDSPYYFLTSAFLTAAIILLHTFWGVVFFD 180

Query: 786 ACERRRYWALGLVVGSHLLTSGLTFLNPWYEASLLPIYAVTVSMGLWAFITAGGSFRSIQ 965
           ACERRRYWALGLVVGSHLLTSGLTFLNPWYEASLLPIYAVTVSMGLWAFITAGGS RSIQ
Sbjct: 181 ACERRRYWALGLVVGSHLLTSGLTFLNPWYEASLLPIYAVTVSMGLWAFITAGGSLRSIQ 240

Query: 966 RSLSCK 983
           RSL C+
Sbjct: 241 RSLLCR 246


>ref|NP_001230700.1| gamma-secretase subunit APH-1A isoform 3 [Homo sapiens].
          Length = 190

 Score =  322 bits (825), Expect = 4e-88
 Identities = 179/247 (72%), Positives = 182/247 (73%)
 Frame = +3

Query: 246 MGAAVFFGCTFVAFGPAFALFLITVAGDPLRVIILVAGXXXXXXXXXXXXXXXXILVHVT 425
           MGAAVFFGCTFVAFGPAFALFL           I VAG                      
Sbjct: 1   MGAAVFFGCTFVAFGPAFALFL-----------ITVAGDP-------------------- 29

Query: 426 DRSDARLQYGLLIFGAAVSVLLQEVFRFAYYKLLKKADEGLASLSEDGRSPISIRQMAYV 605
                 L+  +L+ G                    KADEGLASLSEDGRSPISIRQMAYV
Sbjct: 30  ------LRVIILVAG--------------------KADEGLASLSEDGRSPISIRQMAYV 63

Query: 606 SGLSFGIISGVFSVINILADALGPGVVGIHGDSPYYFLTSAFLTAAIILLHTFWGVVFFD 785
           SGLSFGIISGVFSVINILADALGPGVVGIHGDSPYYFLTSAFLTAAIILLHTFWGVVFFD
Sbjct: 64  SGLSFGIISGVFSVINILADALGPGVVGIHGDSPYYFLTSAFLTAAIILLHTFWGVVFFD 123

Query: 786 ACERRRYWALGLVVGSHLLTSGLTFLNPWYEASLLPIYAVTVSMGLWAFITAGGSFRSIQ 965
           ACERRRYWALGLVVGSHLLTSGLTFLNPWYEASLLPIYAVTVSMGLWAFITAGGS RSIQ
Sbjct: 124 ACERRRYWALGLVVGSHLLTSGLTFLNPWYEASLLPIYAVTVSMGLWAFITAGGSLRSIQ 183

Query: 966 RSLSCKD 986
           RSL CKD
Sbjct: 184 RSLLCKD 190


>ref|NP_112591.2| gamma-secretase subunit APH-1B isoform 1 [Homo sapiens].
          Length = 257

 Score =  262 bits (670), Expect = 4e-70
 Identities = 132/247 (53%), Positives = 172/247 (69%)
 Frame = +3

Query: 246 MGAAVFFGCTFVAFGPAFALFLITVAGDPLRVIILVAGXXXXXXXXXXXXXXXXILVHVT 425
           M AAVFFGC F+AFGPA AL++ T+A +PLR+I L+AG                +   + 
Sbjct: 1   MTAAVFFGCAFIAFGPALALYVFTIATEPLRIIFLIAGAFFWLVSLLISSLVWFMARVII 60

Query: 426 DRSDARLQYGLLIFGAAVSVLLQEVFRFAYYKLLKKADEGLASLSEDGRSPISIRQMAYV 605
           D  D   Q  LLIFGA VSV +QE+FRFAYYKLLKKA EGL S++    +P S+R +AYV
Sbjct: 61  DNKDGPTQKYLLIFGAFVSVYIQEMFRFAYYKLLKKASEGLKSINPGETAP-SMRLLAYV 119

Query: 606 SGLSFGIISGVFSVINILADALGPGVVGIHGDSPYYFLTSAFLTAAIILLHTFWGVVFFD 785
           SGL FGI+SGVFS +N L+D+LGPG VGIHGDSP +FL SAF+T  IILLH FWG+VFFD
Sbjct: 120 SGLGFGIMSGVFSFVNTLSDSLGPGTVGIHGDSPQFFLYSAFMTLVIILLHVFWGIVFFD 179

Query: 786 ACERRRYWALGLVVGSHLLTSGLTFLNPWYEASLLPIYAVTVSMGLWAFITAGGSFRSIQ 965
            CE++++  L +V+ +HLL S  TF++ +Y  +L   + + V MG WAF+ AGGS RS++
Sbjct: 180 GCEKKKWGILLIVLLTHLLVSAQTFISSYYGINLASAFIILVLMGTWAFLAAGGSCRSLK 239

Query: 966 RSLSCKD 986
             L C+D
Sbjct: 240 LCLLCQD 246


>ref|NP_001230701.1| gamma-secretase subunit APH-1A isoform 4 [Homo sapiens].
          Length = 195

 Score =  252 bits (644), Expect(2) = 8e-69
 Identities = 123/127 (96%), Positives = 125/127 (98%)
 Frame = +3

Query: 603 VSGLSFGIISGVFSVINILADALGPGVVGIHGDSPYYFLTSAFLTAAIILLHTFWGVVFF 782
           +SGLSFGIISGVFSVINILADALGPGVVGIHGDSPYYFLTSAFLTAAIILLHTFWGVVFF
Sbjct: 50  ISGLSFGIISGVFSVINILADALGPGVVGIHGDSPYYFLTSAFLTAAIILLHTFWGVVFF 109

Query: 783 DACERRRYWALGLVVGSHLLTSGLTFLNPWYEASLLPIYAVTVSMGLWAFITAGGSFRSI 962
           DACERRRYWALGLVVGSHLLTSGLTFLNPWYEASLLPIYAVTVSMGLWAFITAGGS RSI
Sbjct: 110 DACERRRYWALGLVVGSHLLTSGLTFLNPWYEASLLPIYAVTVSMGLWAFITAGGSLRSI 169

Query: 963 QRSLSCK 983
           QRSL C+
Sbjct: 170 QRSLLCR 176



 Score = 27.7 bits (60), Expect(2) = 8e-69
 Identities = 11/11 (100%), Positives = 11/11 (100%)
 Frame = +1

Query: 496 RCSALPTTSCL 528
           RCSALPTTSCL
Sbjct: 39  RCSALPTTSCL 49



 Score = 78.2 bits (191), Expect = 1e-14
 Identities = 38/38 (100%), Positives = 38/38 (100%)
 Frame = +3

Query: 246 MGAAVFFGCTFVAFGPAFALFLITVAGDPLRVIILVAG 359
           MGAAVFFGCTFVAFGPAFALFLITVAGDPLRVIILVAG
Sbjct: 1   MGAAVFFGCTFVAFGPAFALFLITVAGDPLRVIILVAG 38


>ref|NP_001139118.1| gamma-secretase subunit APH-1B isoform 2 [Homo sapiens].
          Length = 216

 Score =  181 bits (458), Expect = 1e-45
 Identities = 102/247 (41%), Positives = 137/247 (55%)
 Frame = +3

Query: 246 MGAAVFFGCTFVAFGPAFALFLITVAGDPLRVIILVAGXXXXXXXXXXXXXXXXILVHVT 425
           M AAVFFGC F+AFGPA AL++ T+A +PLR+I L+AG                +   + 
Sbjct: 1   MTAAVFFGCAFIAFGPALALYVFTIATEPLRIIFLIAGAFFWLVSLLISSLVWFMARVII 60

Query: 426 DRSDARLQYGLLIFGAAVSVLLQEVFRFAYYKLLKKADEGLASLSEDGRSPISIRQMAYV 605
           D  D   Q  LLIFGA VSV +QE+FRFAYYKLLKKA EGL S++    +P S+R +AY 
Sbjct: 61  DNKDGPTQKYLLIFGAFVSVYIQEMFRFAYYKLLKKASEGLKSINPGETAP-SMRLLAY- 118

Query: 606 SGLSFGIISGVFSVINILADALGPGVVGIHGDSPYYFLTSAFLTAAIILLHTFWGVVFFD 785
                                                   AF+T  IILLH FWG+VFFD
Sbjct: 119 ----------------------------------------AFMTLVIILLHVFWGIVFFD 138

Query: 786 ACERRRYWALGLVVGSHLLTSGLTFLNPWYEASLLPIYAVTVSMGLWAFITAGGSFRSIQ 965
            CE++++  L +V+ +HLL S  TF++ +Y  +L   + + V MG WAF+ AGGS RS++
Sbjct: 139 GCEKKKWGILLIVLLTHLLVSAQTFISSYYGINLASAFIILVLMGTWAFLAAGGSCRSLK 198

Query: 966 RSLSCKD 986
             L C+D
Sbjct: 199 LCLLCQD 205


  Database: RefSeq49_HP.fasta
    Posted date:  Oct 17, 2011  1:42 PM
  Number of letters in database: 18,297,164
  Number of sequences in database:  32,964
  
Lambda     K      H
   0.318    0.134    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 32964
Number of Hits to DB: 51,937,669
Number of extensions: 1651004
Number of successful extensions: 7413
Number of sequences better than 1.0e-05: 6
Number of HSP's gapped: 7373
Number of HSP's successfully gapped: 10
Length of query: 376
Length of database: 18,297,164
Length adjustment: 104
Effective length of query: 272
Effective length of database: 14,868,908
Effective search space: 4044342976
Effective search space used: 4044342976
Neighboring words threshold: 12
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 35 (18.1 bits)

Search to RefSeqMP_Rel49

BLASTX 2.2.24 [Aug-08-2010]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= 20110601C-000625
         (1129 letters)

Database: RefSeq49_MP.fasta 
           30,036 sequences; 15,617,559 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

Alignment   gi|NP_666216.1| gamma-secretase subunit APH-1A isoform 1 [Mus m...   447   e-126
Alignment   gi|NP_666246.1| gamma-secretase subunit APH-1A isoform 2 [Mus m...   443   e-124
Alignment   gi|NP_808251.1| gamma-secretase subunit APH-1B [Mus musculus].       270   2e-72
Alignment   gi|NP_080950.1| putative gamma-secretase subunit APH-1C [Mus mu...   268   8e-72

>ref|NP_666216.1| gamma-secretase subunit APH-1A isoform 1 [Mus musculus].
          Length = 247

 Score =  447 bits (1149), Expect = e-126
 Identities = 229/247 (92%), Positives = 230/247 (93%)
 Frame = +3

Query: 246 MGAAVFFGCTFVAFGPAFALFLITVAGDPLRVIILVAGXXXXXXXXXXXXXXXXILVHVT 425
           MGAAVFFGCTFVAFGPAF+LFLITVAGDPLRVIILVAG                ILVHVT
Sbjct: 1   MGAAVFFGCTFVAFGPAFSLFLITVAGDPLRVIILVAGAFFWLVSLLLASVVWFILVHVT 60

Query: 426 DRSDARLQYGLLIFGAAVSVLLQEVFRFAYYKLLKKADEGLASLSEDGRSPISIRQMAYV 605
           DRSDARLQYGLLIFGAAVSVLLQEVFRFAYYKLLKKADEGLASLSEDGRSPISIRQMAYV
Sbjct: 61  DRSDARLQYGLLIFGAAVSVLLQEVFRFAYYKLLKKADEGLASLSEDGRSPISIRQMAYV 120

Query: 606 SGLSFGIISGVFSVINILADALGPGVVGIHGDSPYYFLTSAFLTAAIILLHTFWGVVFFD 785
           SGLSFGIISGVFSVINILADALGPGVVGIHGDSPYYFLTSAFLTAAIILLHTFWGVVFFD
Sbjct: 121 SGLSFGIISGVFSVINILADALGPGVVGIHGDSPYYFLTSAFLTAAIILLHTFWGVVFFD 180

Query: 786 ACERRRYWALGLVVGSHLLTSGLTFLNPWYEASLLPIYAVTVSMGLWAFITAGGSFRSIQ 965
           ACERRRYWALGLVVGSHLLTSGLTFLNPWYEASLLPIYAVTVSMGLWAFITAGGS RSIQ
Sbjct: 181 ACERRRYWALGLVVGSHLLTSGLTFLNPWYEASLLPIYAVTVSMGLWAFITAGGSLRSIQ 240

Query: 966 RSLSCKD 986
           RSLSCKD
Sbjct: 241 RSLSCKD 247


>ref|NP_666246.1| gamma-secretase subunit APH-1A isoform 2 [Mus musculus].
          Length = 265

 Score =  443 bits (1140), Expect = e-124
 Identities = 227/246 (92%), Positives = 229/246 (93%)
 Frame = +3

Query: 246 MGAAVFFGCTFVAFGPAFALFLITVAGDPLRVIILVAGXXXXXXXXXXXXXXXXILVHVT 425
           MGAAVFFGCTFVAFGPAF+LFLITVAGDPLRVIILVAG                ILVHVT
Sbjct: 1   MGAAVFFGCTFVAFGPAFSLFLITVAGDPLRVIILVAGAFFWLVSLLLASVVWFILVHVT 60

Query: 426 DRSDARLQYGLLIFGAAVSVLLQEVFRFAYYKLLKKADEGLASLSEDGRSPISIRQMAYV 605
           DRSDARLQYGLLIFGAAVSVLLQEVFRFAYYKLLKKADEGLASLSEDGRSPISIRQMAYV
Sbjct: 61  DRSDARLQYGLLIFGAAVSVLLQEVFRFAYYKLLKKADEGLASLSEDGRSPISIRQMAYV 120

Query: 606 SGLSFGIISGVFSVINILADALGPGVVGIHGDSPYYFLTSAFLTAAIILLHTFWGVVFFD 785
           SGLSFGIISGVFSVINILADALGPGVVGIHGDSPYYFLTSAFLTAAIILLHTFWGVVFFD
Sbjct: 121 SGLSFGIISGVFSVINILADALGPGVVGIHGDSPYYFLTSAFLTAAIILLHTFWGVVFFD 180

Query: 786 ACERRRYWALGLVVGSHLLTSGLTFLNPWYEASLLPIYAVTVSMGLWAFITAGGSFRSIQ 965
           ACERRRYWALGLVVGSHLLTSGLTFLNPWYEASLLPIYAVTVSMGLWAFITAGGS RSIQ
Sbjct: 181 ACERRRYWALGLVVGSHLLTSGLTFLNPWYEASLLPIYAVTVSMGLWAFITAGGSLRSIQ 240

Query: 966 RSLSCK 983
           RSLSC+
Sbjct: 241 RSLSCR 246


>ref|NP_808251.1| gamma-secretase subunit APH-1B [Mus musculus].
          Length = 257

 Score =  270 bits (690), Expect = 2e-72
 Identities = 133/247 (53%), Positives = 176/247 (71%)
 Frame = +3

Query: 246 MGAAVFFGCTFVAFGPAFALFLITVAGDPLRVIILVAGXXXXXXXXXXXXXXXXILVHVT 425
           M AAVFFGC F+AFGPA AL++ T+A DPLRVI L+AG                ++  +T
Sbjct: 1   MTAAVFFGCAFIAFGPALALYVFTIATDPLRVIFLIAGAFFWLVSLLLSSVFWFLVRVIT 60

Query: 426 DRSDARLQYGLLIFGAAVSVLLQEVFRFAYYKLLKKADEGLASLSEDGRSPISIRQMAYV 605
           D  D  +Q  LLIFG  +SV +QE+FR AYYKLLKKA EGL S++ +  +P S+R +AYV
Sbjct: 61  DNRDGPVQNYLLIFGVLLSVCIQELFRLAYYKLLKKASEGLKSINPEETAP-SMRLLAYV 119

Query: 606 SGLSFGIISGVFSVINILADALGPGVVGIHGDSPYYFLTSAFLTAAIILLHTFWGVVFFD 785
           SGL FGI+SGVFS +N L+++LGPG VGIHGDSP +FL SAF+T  +I+LH FWGVVFFD
Sbjct: 120 SGLGFGIMSGVFSFVNTLSNSLGPGTVGIHGDSPQFFLNSAFMTLVVIMLHVFWGVVFFD 179

Query: 786 ACERRRYWALGLVVGSHLLTSGLTFLNPWYEASLLPIYAVTVSMGLWAFITAGGSFRSIQ 965
            CE+ +++ L  V+ +HL+ S  TFL+P+YE +L+  Y + V MG+WAF  AGGS RS++
Sbjct: 180 GCEKNKWYTLLTVLLTHLVVSTQTFLSPYYEVNLVTAYIIMVLMGIWAFYVAGGSCRSLK 239

Query: 966 RSLSCKD 986
             L C+D
Sbjct: 240 LCLLCQD 246


>ref|NP_080950.1| putative gamma-secretase subunit APH-1C [Mus musculus].
          Length = 258

 Score =  268 bits (684), Expect = 8e-72
 Identities = 132/247 (53%), Positives = 174/247 (70%)
 Frame = +3

Query: 246 MGAAVFFGCTFVAFGPAFALFLITVAGDPLRVIILVAGXXXXXXXXXXXXXXXXILVHVT 425
           M   VFFGC F+AFGPAFAL+L T+A DPLRVI L+AG                ++  +T
Sbjct: 1   MTLPVFFGCAFIAFGPAFALYLFTIATDPLRVIFLIAGAFFWLVSLLLSSMFWFLVRVIT 60

Query: 426 DRSDARLQYGLLIFGAAVSVLLQEVFRFAYYKLLKKADEGLASLSEDGRSPISIRQMAYV 605
           +  D  +Q  LLIFGA +SV +QE+FR AYYKLLKKA EGL S++ +     S+R +AYV
Sbjct: 61  NNRDESVQNYLLIFGALLSVCIQELFRLAYYKLLKKASEGLKSINPEEDIAPSMRLLAYV 120

Query: 606 SGLSFGIISGVFSVINILADALGPGVVGIHGDSPYYFLTSAFLTAAIILLHTFWGVVFFD 785
           SGL FGI+SGVFS +N L+++LGPG VGIHGDSP +FL SAF+T  +I+LH FWGVVFFD
Sbjct: 121 SGLGFGIMSGVFSFVNTLSNSLGPGTVGIHGDSPQFFLNSAFMTLVVIMLHVFWGVVFFD 180

Query: 786 ACERRRYWALGLVVGSHLLTSGLTFLNPWYEASLLPIYAVTVSMGLWAFITAGGSFRSIQ 965
            CE+ +++ L  V+ +HL+ S  TFL+P+YE +L+  Y + V MG+WAF  AGGS RS++
Sbjct: 181 GCEKNKWYTLLTVLLTHLVVSTQTFLSPYYEVNLVTAYIIMVLMGIWAFYVAGGSCRSLK 240

Query: 966 RSLSCKD 986
             L C+D
Sbjct: 241 FCLLCQD 247


  Database: RefSeq49_MP.fasta
    Posted date:  Oct 17, 2011  1:42 PM
  Number of letters in database: 15,617,559
  Number of sequences in database:  30,036
  
Lambda     K      H
   0.318    0.134    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 30036
Number of Hits to DB: 43,705,965
Number of extensions: 1359379
Number of successful extensions: 5767
Number of sequences better than 1.0e-05: 4
Number of HSP's gapped: 5732
Number of HSP's successfully gapped: 4
Length of query: 376
Length of database: 15,617,559
Length adjustment: 103
Effective length of query: 273
Effective length of database: 12,523,851
Effective search space: 3419011323
Effective search space used: 3419011323
Neighboring words threshold: 12
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 35 (18.1 bits)

Search to RefSeqSP_Rel49

BLASTX 2.2.24 [Aug-08-2010]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= 20110601C-000625
         (1129 letters)

Database: RefSeq49_SP.fasta 
           24,897 sequences; 11,343,932 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

Alignment   gi|XP_001924704.2| PREDICTED: gamma-secretase subunit APH-1A [S...   445   e-125
Alignment   gi|XP_003353379.1| PREDICTED: gamma-secretase subunit APH-1B-li...   181   9e-46
Alignment   gi|XP_003353377.1| PREDICTED: gamma-secretase subunit APH-1B-li...   181   9e-46

>ref|XP_001924704.2| PREDICTED: gamma-secretase subunit APH-1A [Sus scrofa].
          Length = 265

 Score =  445 bits (1144), Expect = e-125
 Identities = 228/246 (92%), Positives = 229/246 (93%)
 Frame = +3

Query: 246 MGAAVFFGCTFVAFGPAFALFLITVAGDPLRVIILVAGXXXXXXXXXXXXXXXXILVHVT 425
           MGAAVFFGCTFVAFGPAF LFLITVAGDPLRVIILVAG                ILVHVT
Sbjct: 1   MGAAVFFGCTFVAFGPAFRLFLITVAGDPLRVIILVAGAFFWLVSLLLASVVWFILVHVT 60

Query: 426 DRSDARLQYGLLIFGAAVSVLLQEVFRFAYYKLLKKADEGLASLSEDGRSPISIRQMAYV 605
           DRSDARLQYGLLIFGAAVSVLLQEVFRFAYYKLLKKADEGLASLSEDGRSPISIRQMAYV
Sbjct: 61  DRSDARLQYGLLIFGAAVSVLLQEVFRFAYYKLLKKADEGLASLSEDGRSPISIRQMAYV 120

Query: 606 SGLSFGIISGVFSVINILADALGPGVVGIHGDSPYYFLTSAFLTAAIILLHTFWGVVFFD 785
           SGLSFGIISGVFSVINILADALGPGVVGIHGDSPYYFLTSAFLTAAIILLHTFWGVVFFD
Sbjct: 121 SGLSFGIISGVFSVINILADALGPGVVGIHGDSPYYFLTSAFLTAAIILLHTFWGVVFFD 180

Query: 786 ACERRRYWALGLVVGSHLLTSGLTFLNPWYEASLLPIYAVTVSMGLWAFITAGGSFRSIQ 965
           ACERRRYWALGLVVGSHLLTSGLTFLNPWYEASLLPIYAVTVSMGLWAFITAGGSFRSIQ
Sbjct: 181 ACERRRYWALGLVVGSHLLTSGLTFLNPWYEASLLPIYAVTVSMGLWAFITAGGSFRSIQ 240

Query: 966 RSLSCK 983
           RSLSC+
Sbjct: 241 RSLSCR 246


>ref|XP_003353379.1| PREDICTED: gamma-secretase subunit APH-1B-like, partial [Sus
           scrofa].
          Length = 159

 Score =  181 bits (458), Expect = 9e-46
 Identities = 92/160 (57%), Positives = 113/160 (70%)
 Frame = +3

Query: 246 MGAAVFFGCTFVAFGPAFALFLITVAGDPLRVIILVAGXXXXXXXXXXXXXXXXILVHVT 425
           M AAVFFGC F+AFGPA AL++ T+A +PLR+I+L+ G                +   +T
Sbjct: 1   MTAAVFFGCAFIAFGPALALYVFTIATEPLRIILLIIGAFFWLVSLLLSSLVWFMATTIT 60

Query: 426 DRSDARLQYGLLIFGAAVSVLLQEVFRFAYYKLLKKADEGLASLSEDGRSPISIRQMAYV 605
           D  D R+Q  LLIFG  VSVL+QE FRFAYYKLLKKA EGL SL+ D  +P S+R +AYV
Sbjct: 61  DNKDERVQKYLLIFGVLVSVLIQETFRFAYYKLLKKASEGLKSLNPDETAP-SMRLLAYV 119

Query: 606 SGLSFGIISGVFSVINILADALGPGVVGIHGDSPYYFLTS 725
           SGL FGI+SGVFS +N L+D+LGPG VGIHGD P +FL S
Sbjct: 120 SGLGFGIMSGVFSFVNTLSDSLGPGTVGIHGDPPQFFLNS 159


>ref|XP_003353377.1| PREDICTED: gamma-secretase subunit APH-1B-like [Sus scrofa].
          Length = 229

 Score =  181 bits (458), Expect = 9e-46
 Identities = 92/160 (57%), Positives = 113/160 (70%)
 Frame = +3

Query: 246 MGAAVFFGCTFVAFGPAFALFLITVAGDPLRVIILVAGXXXXXXXXXXXXXXXXILVHVT 425
           M AAVFFGC F+AFGPA AL++ T+A +PLR+I+L+ G                +   +T
Sbjct: 1   MTAAVFFGCAFIAFGPALALYVFTIATEPLRIILLIIGAFFWLVSLLLSSLVWFMATTIT 60

Query: 426 DRSDARLQYGLLIFGAAVSVLLQEVFRFAYYKLLKKADEGLASLSEDGRSPISIRQMAYV 605
           D  D R+Q  LLIFG  VSVL+QE FRFAYYKLLKKA EGL SL+ D  +P S+R +AYV
Sbjct: 61  DNKDERVQKYLLIFGVLVSVLIQETFRFAYYKLLKKASEGLKSLNPDETAP-SMRLLAYV 119

Query: 606 SGLSFGIISGVFSVINILADALGPGVVGIHGDSPYYFLTS 725
           SGL FGI+SGVFS +N L+D+LGPG VGIHGD P +FL S
Sbjct: 120 SGLGFGIMSGVFSFVNTLSDSLGPGTVGIHGDPPQFFLNS 159


  Database: RefSeq49_SP.fasta
    Posted date:  Oct 17, 2011  1:42 PM
  Number of letters in database: 11,343,932
  Number of sequences in database:  24,897
  
Lambda     K      H
   0.318    0.134    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 24897
Number of Hits to DB: 32,878,564
Number of extensions: 1058278
Number of successful extensions: 4785
Number of sequences better than 1.0e-05: 3
Number of HSP's gapped: 4750
Number of HSP's successfully gapped: 3
Length of query: 376
Length of database: 11,343,932
Length adjustment: 101
Effective length of query: 275
Effective length of database: 8,829,335
Effective search space: 2428067125
Effective search space used: 2428067125
Neighboring words threshold: 12
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 34 (17.7 bits)

Search to Sscrofa10_2

BLASTN 2.2.24 [Aug-08-2010]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= 20110601C-000625
         (1129 letters)

Database: Sscrofa_10.2.fasta 
           4582 sequences; 2,808,509,378 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gb|GL893333.2| Sus scrofa unplaced genomic scaffold ChrUScaf1218      438   e-120

>gb|GL893333.2| Sus scrofa unplaced genomic scaffold ChrUScaf1218
          Length = 75020

 Score =  438 bits (221), Expect = e-120
 Identities = 265/277 (95%), Gaps = 2/277 (0%)
 Strand = Plus / Minus

                                                                         
Query: 854   gacattcctgaacccttggtacgaggcaagcctgctgcccatctatgcagtcactgtttc 913
             ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 14093 gacattcctgaacccttggtacgaggcaagcctgctgcccatctatgcagtcactgtttc 14034

                                                                         
Query: 914   catggggctctgggccttcatcacagctggagggtccttccgaagtatccagcgcagtct 973
             ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 14033 catggggctctgggccttcatcacagctggagggtccttccgaagtatccagcgcagtct 13974

                                                                         
Query: 974   ctcgtgtaaggactgactacctggactgatcgcctgacagatccca-ctgcctgcccact 1032
             |||||||||||||||||||||||||||||||||||||||||||||| |||||||||||||
Sbjct: 13973 ctcgtgtaaggactgactacctggactgatcgcctgacagatcccacctgcctgcccact 13914

                                                                         
Query: 1033  gcccatgaatgaacccagccccacccgggtccatatgcccatcattccctgtccccctct 1092
             |||||||| ||| ||||||||||||||||||||| |||||||||||| ||||| ||   |
Sbjct: 13913 gcccatgactgagcccagccccacccgggtccat-tgcccatcattctctgtctcctcgt 13855

                                                  
Query: 1093  cggccttttccacacccttcagggttttgctttgtcc 1129
             ||| |||||||||  ||||||||||||||||||||||
Sbjct: 13854 cggtcttttccaccaccttcagggttttgctttgtcc 13818



 Score =  343 bits (173), Expect = 1e-91
 Identities = 173/173 (100%)
 Strand = Plus / Minus

                                                                         
Query: 358   gggcatttttctggctggtctccttgctcttggcctctgtagtctggttcatcttggtcc 417
             ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 15690 gggcatttttctggctggtctccttgctcttggcctctgtagtctggttcatcttggtcc 15631

                                                                         
Query: 418   atgtgaccgaccggtcagatgcccggctccagtatggcctcctgatttttggtgctgcag 477
             ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 15630 atgtgaccgaccggtcagatgcccggctccagtatggcctcctgatttttggtgctgcag 15571

                                                                  
Query: 478   tttctgtccttctacaggaggtgttccgctttgcctactacaagctgcttaag 530
             |||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 15570 tttctgtccttctacaggaggtgttccgctttgcctactacaagctgcttaag 15518



 Score =  321 bits (162), Expect = 5e-85
 Identities = 162/162 (100%)
 Strand = Plus / Minus

                                                                         
Query: 122   gggtgacattgcaccgcgccccttacggggtcgcgtcgccaacgaacgcggacactctag 181
             ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 16585 gggtgacattgcaccgcgccccttacggggtcgcgtcgccaacgaacgcggacactctag 16526

                                                                         
Query: 182   ttggcgtgctcctccccttcgcctctcttagccaggcctccaccccgcccccagctgccc 241
             ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 16525 ttggcgtgctcctccccttcgcctctcttagccaggcctccaccccgcccccagctgccc 16466

                                                       
Query: 242   agccatgggggccgcagtgttttttggatgcactttcgtcgc 283
             ||||||||||||||||||||||||||||||||||||||||||
Sbjct: 16465 agccatgggggccgcagtgttttttggatgcactttcgtcgc 16424



 Score =  260 bits (131), Expect = 1e-66
 Identities = 131/131 (100%)
 Strand = Plus / Minus

                                                                         
Query: 724   cagcctttctgacagcagccattatcctgctccataccttttggggagtcgtgttctttg 783
             ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 14652 cagcctttctgacagcagccattatcctgctccataccttttggggagtcgtgttctttg 14593

                                                                         
Query: 784   atgcctgtgagaggagacggtactgggctttgggcctggtggttgggagtcacctactga 843
             ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 14592 atgcctgtgagaggagacggtactgggctttgggcctggtggttgggagtcacctactga 14533

                        
Query: 844   catcaggactg 854
             |||||||||||
Sbjct: 14532 catcaggactg 14522



 Score =  246 bits (124), Expect = 2e-62
 Identities = 124/124 (100%)
 Strand = Plus / Minus

                                                                         
Query: 603   gtttctggtctttccttcggtatcatcagtggtgtcttctctgttatcaatattttggct 662
             ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 14927 gtttctggtctttccttcggtatcatcagtggtgtcttctctgttatcaatattttggct 14868

                                                                         
Query: 663   gatgcacttgggccaggtgtggttgggatccatggagactcaccctattacttcttgact 722
             ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 14867 gatgcacttgggccaggtgtggttgggatccatggagactcaccctattacttcttgact 14808

                 
Query: 723   tcag 726
             ||||
Sbjct: 14807 tcag 14804



 Score =  149 bits (75), Expect = 4e-33
 Identities = 75/75 (100%)
 Strand = Plus / Minus

                                                                         
Query: 5     agatgggaggtggccatggggctgcggatggggtttgtccccttttcggcttccgtagag 64
             ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 16760 agatgggaggtggccatggggctgcggatggggtttgtccccttttcggcttccgtagag 16701

                            
Query: 65    gaagtcgcggggacc 79
             |||||||||||||||
Sbjct: 16700 gaagtcgcggggacc 16686



 Score =  147 bits (74), Expect = 2e-32
 Identities = 74/74 (100%)
 Strand = Plus / Minus

                                                                         
Query: 530   gaaggcagatgaggggttagcatcgctgagtgaggacggaagatcacccatctccatccg 589
             ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 15248 gaaggcagatgaggggttagcatcgctgagtgaggacggaagatcacccatctccatccg 15189

                           
Query: 590   gcagatggcctatg 603
             ||||||||||||||
Sbjct: 15188 gcagatggcctatg 15175



 Score =  137 bits (69), Expect = 1e-29
 Identities = 75/77 (97%)
 Strand = Plus / Minus

                                                                         
Query: 283   ctttcggtccagcctttgcgcttttcttgatcactgtggccggagacccgcttcgtgtca 342
             |||||||||||||||||  |||||||||||||||||||||||||||||||||||||||||
Sbjct: 16323 ctttcggtccagcctttaggcttttcttgatcactgtggccggagacccgcttcgtgtca 16264

                              
Query: 343   tcatcctagtcgctggg 359
             |||||||||||||||||
Sbjct: 16263 tcatcctagtcgctggg 16247


  Database: Sscrofa_10.2.fasta
    Posted date:  Nov 16, 2011 10:34 AM
  Number of letters in database: 2,808,509,378
  Number of sequences in database:  4582
  
Lambda     K      H
    1.37    0.711     1.31 

Gapped
Lambda     K      H
    1.37    0.711     1.31 


Matrix: blastn matrix:1 -3
Gap Penalties: Existence: 5, Extension: 2
Number of Sequences: 4582
Number of Hits to DB: 29,194,497
Number of extensions: 206
Number of successful extensions: 206
Number of sequences better than 1.0e-05: 1
Number of HSP's gapped: 204
Number of HSP's successfully gapped: 8
Length of query: 1129
Length of database: 2,808,509,378
Length adjustment: 21
Effective length of query: 1108
Effective length of database: 2,808,413,156
Effective search space: 3111721776848
Effective search space used: 3111721776848
X1: 11 (21.8 bits)
X2: 15 (29.7 bits)
X3: 50 (99.1 bits)
S1: 18 (36.2 bits)
S2: 30 (60.0 bits)