Animal-Genome cDNA 20110601C-000824

BLASTX 2.2.24 [Aug-08-2010]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= 20110601C-000824
         (1206 letters)

Database: RefSeq49_BP.fasta 
           33,088 sequences; 17,681,374 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

Alignment   gi|NP_001035691.1| ras suppressor protein 1 [Bos taurus].            534   e-152
Alignment   gi|NP_001077210.1| leucine-rich repeat-containing protein 8D [B...   112   7e-25
Alignment   gi|NP_001070275.1| leucine-rich repeat-containing protein 8A [B...   109   6e-24
Alignment   gi|NP_001192398.1| leucine-rich repeat-containing protein 1 [Bo...   108   9e-24
Alignment   gi|XP_002697221.1| PREDICTED: PDZ-domain protein scribble-like ...   108   9e-24
Alignment   gi|XP_002699984.1| PREDICTED: leucine-rich repeats and calponin...   107   2e-23
Alignment   gi|XP_618181.3| PREDICTED: leucine-rich repeats and calponin ho...   107   2e-23
Alignment   gi|XP_002686307.1| PREDICTED: leucine rich repeat containing 8 ...   103   3e-22
Alignment   gi|XP_595756.4| PREDICTED: leucine rich repeat containing 8 fam...   103   3e-22
Alignment   gi|NP_001193082.1| protein LAP2 [Bos taurus].                        102   5e-22

>ref|NP_001035691.1| ras suppressor protein 1 [Bos taurus].
          Length = 277

 Score =  534 bits (1375), Expect = e-152
 Identities = 267/274 (97%), Positives = 271/274 (98%)
 Frame = +2

Query: 257  MSKSLKKLVEESREKNQPEVDMSDRGISNMLDVNGLFTLAHITQLVLSHNKLTTVPPNIA 436
            MSKSLKKLVEESREKNQPEVDMSDRGISNMLD+NGLFTL+HITQLVLSHNKLTTVPPNIA
Sbjct: 1    MSKSLKKLVEESREKNQPEVDMSDRGISNMLDINGLFTLSHITQLVLSHNKLTTVPPNIA 60

Query: 437  ELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNN 616
            ELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNN
Sbjct: 61   ELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNN 120

Query: 617  LSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELT 796
            L+ENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELT
Sbjct: 121  LNENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELT 180

Query: 797  QLKELHIQGNRLTVLPPELGNLDLTGQKQIFKAENNPWVTPIADQFQLGVSHVFEYIRSE 976
            QLKELHIQGNRLTVLPPELGNLDLTGQKQIFKAENNPWVTPIADQFQLGVSHVFEYIRSE
Sbjct: 181  QLKELHIQGNRLTVLPPELGNLDLTGQKQIFKAENNPWVTPIADQFQLGVSHVFEYIRSE 240

Query: 977  TYKYLYGRHMQANPEPPE*NNDTSKKISRKPLTA 1078
            TYKYLYGRHMQANPEPP+ NND SKKISRKPL A
Sbjct: 241  TYKYLYGRHMQANPEPPKKNNDKSKKISRKPLAA 274


>ref|NP_001077210.1| leucine-rich repeat-containing protein 8D [Bos taurus].
          Length = 858

 Score =  112 bits (280), Expect = 7e-25
 Identities = 66/189 (34%), Positives = 103/189 (54%)
 Frame = +2

Query: 302  NQPEVDMSDRGISNMLDVNGLFTLAHITQLVLSHNKLTTVPPNIAELKNLEVLNFFNNQI 481
            N  E+D+    I  + ++     L  +T L L HNK+ T+PP+I  +KNLE L F NN++
Sbjct: 659  NLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKL 718

Query: 482  EELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTT 661
            E LP  + SLQKL+                        LD++YNN+S   +P     L  
Sbjct: 719  ESLPVAVFSLQKLR-----------------------CLDVSYNNIS--MIPVEIGLLQN 753

Query: 662  LRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVL 841
            L+ L+++ N  ++LP  + K  K++ L+L  N + SLP++IG+L+QL +L ++GN L  L
Sbjct: 754  LQHLHITGNKVDVLPKQLFKCVKMRTLNLGQNCITSLPEKIGQLSQLTQLELKGNCLDRL 813

Query: 842  PPELGNLDL 868
            P +LG   L
Sbjct: 814  PAQLGQCRL 822



 Score = 82.0 bits (201), Expect = 9e-16
 Identities = 57/185 (30%), Positives = 98/185 (52%), Gaps = 2/185 (1%)
 Frame = +2

Query: 338  SNMLDVNGLFTLAHITQLVLSHNKLTTVPPNIAELKNLEVLNFFNNQIEELPTQIS--SL 511
            + +L +N L  + ++ +L L + +L  +P  I  L NL+ L+  +N I  +   IS   L
Sbjct: 623  TKLLVLNSLKKMMNVAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHL 682

Query: 512  QKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDND 691
            ++L  L L  N++ T+P     +  LE L  + N L   SLP   F L  LR L +S N+
Sbjct: 683  KRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLE--SLPVAVFSLQKLRCLDVSYNN 740

Query: 692  FEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNLDLT 871
              ++P +IG L  LQ L +  N +  LPK++ +  +++ L++  N +T LP ++G L   
Sbjct: 741  ISMIPVEIGLLQNLQHLHITGNKVDVLPKQLFKCVKMRTLNLGQNCITSLPEKIGQLSQL 800

Query: 872  GQKQI 886
             Q ++
Sbjct: 801  TQLEL 805


>ref|NP_001070275.1| leucine-rich repeat-containing protein 8A [Bos taurus].
          Length = 810

 Score =  109 bits (272), Expect = 6e-24
 Identities = 67/186 (36%), Positives = 101/186 (54%), Gaps = 2/186 (1%)
 Frame = +2

Query: 302  NQPEVDMSDRGISNMLDVNGLFTLAHITQLVLSHNKLTTVPPNIAELKNLEVLNFFNNQI 481
            N  E+D+ D  +  + ++     L  +T L L +N +  +P  I  L NLE L    N+I
Sbjct: 615  NLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKI 674

Query: 482  EELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTT 661
            E++PTQ+   +KL++L+L  N L  LP   G L +L+ L +T N +   +LP   F    
Sbjct: 675  EKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQSLQNLAVTANRI--EALPPELFQCRK 732

Query: 662  LRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKE--LHIQGNRLT 835
            LRAL+L +N  + LP  +G+LT L  + LR N L  LP E+GE   LK   L ++ +   
Sbjct: 733  LRALHLGNNVLQSLPSRVGELTSLTQIELRGNRLECLPVELGECPLLKRSGLVVEEDLFN 792

Query: 836  VLPPEL 853
             LPPE+
Sbjct: 793  TLPPEV 798



 Score =  101 bits (251), Expect = 2e-21
 Identities = 62/173 (35%), Positives = 96/173 (55%), Gaps = 2/173 (1%)
 Frame = +2

Query: 356  NGLFTLAHITQLVLSHNKLTTVPPNIA--ELKNLEVLNFFNNQIEELPTQISSLQKLKHL 529
            + +F+L ++ ++ L  N L T+   I+   L  L  L  + N I  +P QI +L  L+ L
Sbjct: 608  HSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERL 667

Query: 530  NLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPP 709
             L  N++  +P        L  LDL++NNL+   LP +   L +L+ L ++ N  E LPP
Sbjct: 668  YLNRNKIEKIPTQLFYCRKLRYLDLSHNNLT--FLPADIGLLQSLQNLAVTANRIEALPP 725

Query: 710  DIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNLDL 868
            ++ +  KL+ L L +N L SLP  +GELT L ++ ++GNRL  LP ELG   L
Sbjct: 726  ELFQCRKLRALHLGNNVLQSLPSRVGELTSLTQIELRGNRLECLPVELGECPL 778



 Score = 58.9 bits (141), Expect = 9e-09
 Identities = 54/187 (28%), Positives = 80/187 (42%), Gaps = 25/187 (13%)
 Frame = +2

Query: 377  HITQLVLSHNKLTTVPPNIAELKNLEVLNFFNNQIEELPTQISS----LQKLKHLNLGMN 544
            H+T  + + N    V   + ELK L+VL   +N + +LP  ++     LQKL   N G  
Sbjct: 522  HLTGNLSAENNRFIVIDGLRELKRLKVLRLKSN-LSKLPQVVTDVGVHLQKLSINNEGTK 580

Query: 545  R---------------------LNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTT 661
                                  L  +P    SL  L+ +DL  NNL       +F +L  
Sbjct: 581  LIVLNSLKKMANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHR 640

Query: 662  LRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVL 841
            L  L L  N    +P  IG LT L+ L L  N +  +P ++    +L+ L +  N LT L
Sbjct: 641  LTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFL 700

Query: 842  PPELGNL 862
            P ++G L
Sbjct: 701  PADIGLL 707


>ref|NP_001192398.1| leucine-rich repeat-containing protein 1 [Bos taurus].
          Length = 524

 Score =  108 bits (270), Expect = 9e-24
 Identities = 67/164 (40%), Positives = 92/164 (56%)
 Frame = +2

Query: 371 LAHITQLVLSHNKLTTVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRL 550
           L ++  L L  N LT +P ++ +L+ LE L+  NN+I  LP  I +L  LK L L  N+L
Sbjct: 150 LYNLASLELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLPESIGALLHLKDLWLDGNQL 209

Query: 551 NTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTK 730
           + LP+  G+L  L  LD++ N L    LP     LT+L  L +S N  E+LP  IGKL K
Sbjct: 210 SELPQEIGNLKNLLCLDVSENRLER--LPEEISGLTSLTDLVISQNLLEMLPDGIGKLKK 267

Query: 731 LQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNL 862
           L IL +  N L  LP+ +G+   L EL +  NRL  LP  +G L
Sbjct: 268 LSILKVDQNRLTQLPEAVGDCESLTELVLTENRLLTLPKSIGKL 311



 Score =  107 bits (267), Expect = 2e-23
 Identities = 72/196 (36%), Positives = 101/196 (51%), Gaps = 6/196 (3%)
 Frame = +2

Query: 311 EVDMSDRGISNMLDVNGLFTLAHITQLVLSHNKLTTVPPNIAELKNLEVLNFFNNQIEEL 490
           E+D+ +  I N+ +  G   L H+  L L  N+L+ +P  I  LKNL  L+   N++E L
Sbjct: 178 ELDLGNNEIYNLPESIG--ALLHLKDLWLDGNQLSELPQEIGNLKNLLCLDVSENRLERL 235

Query: 491 PTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRA 670
           P +IS L  L  L +  N L  LP G G L  L +L +  N L++  LP       +L  
Sbjct: 236 PEEISGLTSLTDLVISQNLLEMLPDGIGKLKKLSILKVDQNRLTQ--LPEAVGDCESLTE 293

Query: 671 LYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPE 850
           L L++N    LP  IGKL KL  L+   N L+SLPKEIG    L    ++ NRLT +P E
Sbjct: 294 LVLTENRLLTLPKSIGKLKKLSNLNADRNKLVSLPKEIGGCCSLTVFCVRDNRLTRIPAE 353

Query: 851 LGN------LDLTGQK 880
           +        LD+ G +
Sbjct: 354 VSRAAELHVLDVAGNR 369



 Score =  102 bits (255), Expect = 5e-22
 Identities = 66/180 (36%), Positives = 96/180 (53%), Gaps = 7/180 (3%)
 Frame = +2

Query: 344 MLDVNGL-------FTLAHITQLVLSHNKLTTVPPNIAELKNLEVLNFFNNQIEELPTQI 502
           +LD N L       F L  + +L LS N++  +PP IA    L  L+   N I E+P  I
Sbjct: 42  LLDANQLRELPEQFFQLVKLRKLGLSDNEIQRLPPEIANFMQLVELDVSRNDIPEIPESI 101

Query: 503 SSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLS 682
           S  + L+  +   N L  LP  F  L  L  L +  N++S  SLP N   L  L +L L 
Sbjct: 102 SFCKALQIADFSGNPLTRLPESFPELQNLTCLSV--NDISLQSLPENIGNLYNLASLELR 159

Query: 683 DNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNL 862
           +N    LP  + +L +L+ L L +N++ +LP+ IG L  LK+L + GN+L+ LP E+GNL
Sbjct: 160 ENLLTYLPDSLTQLRRLEELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQEIGNL 219



 Score = 87.0 bits (214), Expect = 3e-17
 Identities = 57/167 (34%), Positives = 86/167 (51%)
 Frame = +2

Query: 356 NGLFTLAHITQLVLSHNKLTTVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNL 535
           + L  L  + +L L +N++  +P +I  L +L+ L    NQ+ ELP +I +L+ L  L++
Sbjct: 168 DSLTQLRRLEELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQEIGNLKNLLCLDV 227

Query: 536 GMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDI 715
             NRL  LP     L +L  L ++ N L    LP     L  L  L +  N    LP  +
Sbjct: 228 SENRLERLPEEISGLTSLTDLVISQNLL--EMLPDGIGKLKKLSILKVDQNRLTQLPEAV 285

Query: 716 GKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELG 856
           G    L  L L +N L++LPK IG+L +L  L+   N+L  LP E+G
Sbjct: 286 GDCESLTELVLTENRLLTLPKSIGKLKKLSNLNADRNKLVSLPKEIG 332



 Score = 81.6 bits (200), Expect = 1e-15
 Identities = 59/191 (30%), Positives = 88/191 (46%), Gaps = 1/191 (0%)
 Frame = +2

Query: 299 KNQPEVDMSDRGISNMLD-VNGLFTLAHITQLVLSHNKLTTVPPNIAELKNLEVLNFFNN 475
           KN   +D+S+  +  + + ++GL +L   T LV+S N L  +P  I +LK L +L    N
Sbjct: 220 KNLLCLDVSENRLERLPEEISGLTSL---TDLVISQNLLEMLPDGIGKLKKLSILKVDQN 276

Query: 476 QIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYL 655
           ++ +LP  +   + L  L L  NRL TLP+  G L  L  L+   N L            
Sbjct: 277 RLTQLPEAVGDCESLTELVLTENRLLTLPKSIGKLKKLSNLNADRNKLVS---------- 326

Query: 656 TTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLT 835
                          LP +IG    L +  +RDN L  +P E+    +L  L + GNRL+
Sbjct: 327 ---------------LPKEIGGCCSLTVFCVRDNRLTRIPAEVSRAAELHVLDVAGNRLS 371

Query: 836 VLPPELGNLDL 868
            LP  L  L+L
Sbjct: 372 HLPLSLTALNL 382


>ref|XP_002697221.1| PREDICTED: PDZ-domain protein scribble-like [Bos taurus].
          Length = 524

 Score =  108 bits (270), Expect = 9e-24
 Identities = 67/164 (40%), Positives = 92/164 (56%)
 Frame = +2

Query: 371 LAHITQLVLSHNKLTTVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRL 550
           L ++  L L  N LT +P ++ +L+ LE L+  NN+I  LP  I +L  LK L L  N+L
Sbjct: 150 LYNLASLELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLPESIGALLHLKDLWLDGNQL 209

Query: 551 NTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTK 730
           + LP+  G+L  L  LD++ N L    LP     LT+L  L +S N  E+LP  IGKL K
Sbjct: 210 SELPQEIGNLKNLLCLDVSENRLER--LPEEISGLTSLTDLVISQNLLEMLPDGIGKLKK 267

Query: 731 LQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNL 862
           L IL +  N L  LP+ +G+   L EL +  NRL  LP  +G L
Sbjct: 268 LSILKVDQNRLTQLPEAVGDCESLTELVLTENRLLTLPKSIGKL 311



 Score =  107 bits (267), Expect = 2e-23
 Identities = 72/196 (36%), Positives = 101/196 (51%), Gaps = 6/196 (3%)
 Frame = +2

Query: 311 EVDMSDRGISNMLDVNGLFTLAHITQLVLSHNKLTTVPPNIAELKNLEVLNFFNNQIEEL 490
           E+D+ +  I N+ +  G   L H+  L L  N+L+ +P  I  LKNL  L+   N++E L
Sbjct: 178 ELDLGNNEIYNLPESIG--ALLHLKDLWLDGNQLSELPQEIGNLKNLLCLDVSENRLERL 235

Query: 491 PTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRA 670
           P +IS L  L  L +  N L  LP G G L  L +L +  N L++  LP       +L  
Sbjct: 236 PEEISGLTSLTDLVISQNLLEMLPDGIGKLKKLSILKVDQNRLTQ--LPEAVGDCESLTE 293

Query: 671 LYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPE 850
           L L++N    LP  IGKL KL  L+   N L+SLPKEIG    L    ++ NRLT +P E
Sbjct: 294 LVLTENRLLTLPKSIGKLKKLSNLNADRNKLVSLPKEIGGCCSLTVFCVRDNRLTRIPAE 353

Query: 851 LGN------LDLTGQK 880
           +        LD+ G +
Sbjct: 354 VSRAAELHVLDVAGNR 369



 Score =  102 bits (255), Expect = 5e-22
 Identities = 66/180 (36%), Positives = 96/180 (53%), Gaps = 7/180 (3%)
 Frame = +2

Query: 344 MLDVNGL-------FTLAHITQLVLSHNKLTTVPPNIAELKNLEVLNFFNNQIEELPTQI 502
           +LD N L       F L  + +L LS N++  +PP IA    L  L+   N I E+P  I
Sbjct: 42  LLDANQLRELPEQFFQLVKLRKLGLSDNEIQRLPPEIANFMQLVELDVSRNDIPEIPESI 101

Query: 503 SSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLS 682
           S  + L+  +   N L  LP  F  L  L  L +  N++S  SLP N   L  L +L L 
Sbjct: 102 SFCKALQIADFSGNPLTRLPESFPELQNLTCLSV--NDISLQSLPENIGNLYNLASLELR 159

Query: 683 DNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNL 862
           +N    LP  + +L +L+ L L +N++ +LP+ IG L  LK+L + GN+L+ LP E+GNL
Sbjct: 160 ENLLTYLPDSLTQLRRLEELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQEIGNL 219



 Score = 87.0 bits (214), Expect = 3e-17
 Identities = 57/167 (34%), Positives = 86/167 (51%)
 Frame = +2

Query: 356 NGLFTLAHITQLVLSHNKLTTVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNL 535
           + L  L  + +L L +N++  +P +I  L +L+ L    NQ+ ELP +I +L+ L  L++
Sbjct: 168 DSLTQLRRLEELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQEIGNLKNLLCLDV 227

Query: 536 GMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDI 715
             NRL  LP     L +L  L ++ N L    LP     L  L  L +  N    LP  +
Sbjct: 228 SENRLERLPEEISGLTSLTDLVISQNLL--EMLPDGIGKLKKLSILKVDQNRLTQLPEAV 285

Query: 716 GKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELG 856
           G    L  L L +N L++LPK IG+L +L  L+   N+L  LP E+G
Sbjct: 286 GDCESLTELVLTENRLLTLPKSIGKLKKLSNLNADRNKLVSLPKEIG 332



 Score = 81.6 bits (200), Expect = 1e-15
 Identities = 59/191 (30%), Positives = 88/191 (46%), Gaps = 1/191 (0%)
 Frame = +2

Query: 299 KNQPEVDMSDRGISNMLD-VNGLFTLAHITQLVLSHNKLTTVPPNIAELKNLEVLNFFNN 475
           KN   +D+S+  +  + + ++GL +L   T LV+S N L  +P  I +LK L +L    N
Sbjct: 220 KNLLCLDVSENRLERLPEEISGLTSL---TDLVISQNLLEMLPDGIGKLKKLSILKVDQN 276

Query: 476 QIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYL 655
           ++ +LP  +   + L  L L  NRL TLP+  G L  L  L+   N L            
Sbjct: 277 RLTQLPEAVGDCESLTELVLTENRLLTLPKSIGKLKKLSNLNADRNKLVS---------- 326

Query: 656 TTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLT 835
                          LP +IG    L +  +RDN L  +P E+    +L  L + GNRL+
Sbjct: 327 ---------------LPKEIGGCCSLTVFCVRDNRLTRIPAEVSRAAELHVLDVAGNRLS 371

Query: 836 VLPPELGNLDL 868
            LP  L  L+L
Sbjct: 372 HLPLSLTALNL 382


>ref|XP_002699984.1| PREDICTED: leucine-rich repeats and calponin homology (CH) domain
           containing 2 [Bos taurus].
          Length = 453

 Score =  107 bits (267), Expect = 2e-23
 Identities = 76/225 (33%), Positives = 118/225 (52%), Gaps = 9/225 (4%)
 Frame = +2

Query: 320 MSDRGISNMLDVNGL---------FTLAHITQLVLSHNKLTTVPPNIAELKNLEVLNFFN 472
           + + G S +L ++G          + L   TQ  LS N+ T +P  +     LE LN ++
Sbjct: 85  LEEAGNSGILSLSGRKLRDFPGSGYDLTDTTQADLSRNRFTEIPSEVWLFAPLETLNLYH 144

Query: 473 NQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFY 652
           N I+ +P  I +LQ L +LN+  N L+TLP+    LP L+VL L+ N L   S+P     
Sbjct: 145 NCIKIIPEAIKNLQMLTYLNISRNLLSTLPKYLFDLP-LKVLVLSNNKLV--SIPEEIGK 201

Query: 653 LTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRL 832
           L  L  L +S N+ ++LP  +GKL  L+ L++R N+L +LP E+G+L  +K L    N++
Sbjct: 202 LKDLMELDISCNEIQVLPQQMGKLQSLRELNIRRNNLQALPDELGDLPLVK-LDFSCNKV 260

Query: 833 TVLPPELGNLDLTGQKQIFKAENNPWVTPIADQFQLGVSHVFEYI 967
           T +P     L      Q+   +NNP   P A     G  H+F+Y+
Sbjct: 261 TEIPVCYRKLH---HLQVIILDNNPLQVPPAQICLKGKVHIFKYL 302


>ref|XP_618181.3| PREDICTED: leucine-rich repeats and calponin homology (CH) domain
           containing 2 [Bos taurus].
          Length = 766

 Score =  107 bits (267), Expect = 2e-23
 Identities = 76/225 (33%), Positives = 118/225 (52%), Gaps = 9/225 (4%)
 Frame = +2

Query: 320 MSDRGISNMLDVNGL---------FTLAHITQLVLSHNKLTTVPPNIAELKNLEVLNFFN 472
           + + G S +L ++G          + L   TQ  LS N+ T +P  +     LE LN ++
Sbjct: 85  LEEAGNSGILSLSGRKLRDFPGSGYDLTDTTQADLSRNRFTEIPSEVWLFAPLETLNLYH 144

Query: 473 NQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFY 652
           N I+ +P  I +LQ L +LN+  N L+TLP+    LP L+VL L+ N L   S+P     
Sbjct: 145 NCIKIIPEAIKNLQMLTYLNISRNLLSTLPKYLFDLP-LKVLVLSNNKLV--SIPEEIGK 201

Query: 653 LTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRL 832
           L  L  L +S N+ ++LP  +GKL  L+ L++R N+L +LP E+G+L  +K L    N++
Sbjct: 202 LKDLMELDISCNEIQVLPQQMGKLQSLRELNIRRNNLQALPDELGDLPLVK-LDFSCNKV 260

Query: 833 TVLPPELGNLDLTGQKQIFKAENNPWVTPIADQFQLGVSHVFEYI 967
           T +P     L      Q+   +NNP   P A     G  H+F+Y+
Sbjct: 261 TEIPVCYRKLH---HLQVIILDNNPLQVPPAQICLKGKVHIFKYL 302


>ref|XP_002686307.1| PREDICTED: leucine rich repeat containing 8 family, member B [Bos
            taurus].
          Length = 804

 Score =  103 bits (257), Expect = 3e-22
 Identities = 67/198 (33%), Positives = 104/198 (52%), Gaps = 4/198 (2%)
 Frame = +2

Query: 356  NGLFTLAHITQLVLSHNKLTTVPPNIA--ELKNLEVLNFFNNQIEELPTQISSLQKLKHL 529
            + +F+L ++ +L L  N L TV   I+   L+NL  L  ++N I  +P QI +L  L+ L
Sbjct: 603  HSIFSLNNLHELDLRENNLKTVEEIISFQHLQNLSCLKLWHNNIAYIPAQIGALSNLEQL 662

Query: 530  NLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPP 709
            +L  N +  LP        L  LDL+YN+L+   +P    YL+ L+   +++N+ E+LP 
Sbjct: 663  SLDHNNIENLPLQLFLCTKLHYLDLSYNHLT--FIPEEIQYLSNLQYFAVTNNNIEMLPD 720

Query: 710  DIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNLDLTGQKQIF 889
             + +  KLQ L L  N L+SL   +GEL+ L  L + GN L  LPPEL       +  + 
Sbjct: 721  GLFQCKKLQCLLLGKNSLMSLSPHVGELSNLTHLELIGNYLETLPPELEGCQSLKRSCLI 780

Query: 890  KAEN--NPWVTPIADQFQ 937
              EN  N    P+ ++ Q
Sbjct: 781  VEENLLNTLPPPVTERLQ 798



 Score = 62.4 bits (150), Expect = 8e-10
 Identities = 56/188 (29%), Positives = 87/188 (46%), Gaps = 2/188 (1%)
 Frame = +2

Query: 347  LDVNGLFTLAHITQLVLSHNKLTTVPPNIAEL-KNLEVLNFFNNQIEELP-TQISSLQKL 520
            + + G   L ++  L L  + L+ +P  I +L  +L+ L+  N   + +    +  +  L
Sbjct: 530  MQLEGFQDLKNLRTLYLK-SSLSRIPQVITDLLPSLQKLSLDNEGSKLVVLNNLKKMVNL 588

Query: 521  KHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEI 700
            K L L    L  +P    SL  L  LDL  NNL       +F +L  L  L L  N+   
Sbjct: 589  KSLELISCDLERIPHSIFSLNNLHELDLRENNLKTVEEIISFQHLQNLSCLKLWHNNIAY 648

Query: 701  LPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNLDLTGQK 880
            +P  IG L+ L+ LSL  N++ +LP ++   T+L  L +  N LT +P E+  L      
Sbjct: 649  IPAQIGALSNLEQLSLDHNNIENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYL---SNL 705

Query: 881  QIFKAENN 904
            Q F   NN
Sbjct: 706  QYFAVTNN 713


>ref|XP_595756.4| PREDICTED: leucine rich repeat containing 8 family, member B [Bos
            taurus].
          Length = 804

 Score =  103 bits (257), Expect = 3e-22
 Identities = 67/198 (33%), Positives = 104/198 (52%), Gaps = 4/198 (2%)
 Frame = +2

Query: 356  NGLFTLAHITQLVLSHNKLTTVPPNIA--ELKNLEVLNFFNNQIEELPTQISSLQKLKHL 529
            + +F+L ++ +L L  N L TV   I+   L+NL  L  ++N I  +P QI +L  L+ L
Sbjct: 603  HSIFSLNNLHELDLRENNLKTVEEIISFQHLQNLSCLKLWHNNIAYIPAQIGALSNLEQL 662

Query: 530  NLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPP 709
            +L  N +  LP        L  LDL+YN+L+   +P    YL+ L+   +++N+ E+LP 
Sbjct: 663  SLDHNNIENLPLQLFLCTKLHYLDLSYNHLT--FIPEEIQYLSNLQYFAVTNNNIEMLPD 720

Query: 710  DIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNLDLTGQKQIF 889
             + +  KLQ L L  N L+SL   +GEL+ L  L + GN L  LPPEL       +  + 
Sbjct: 721  GLFQCKKLQCLLLGKNSLMSLSPHVGELSNLTHLELIGNYLETLPPELEGCQSLKRSCLI 780

Query: 890  KAEN--NPWVTPIADQFQ 937
              EN  N    P+ ++ Q
Sbjct: 781  VEENLLNTLPPPVTERLQ 798



 Score = 62.4 bits (150), Expect = 8e-10
 Identities = 56/188 (29%), Positives = 87/188 (46%), Gaps = 2/188 (1%)
 Frame = +2

Query: 347  LDVNGLFTLAHITQLVLSHNKLTTVPPNIAEL-KNLEVLNFFNNQIEELP-TQISSLQKL 520
            + + G   L ++  L L  + L+ +P  I +L  +L+ L+  N   + +    +  +  L
Sbjct: 530  MQLEGFQDLKNLRTLYLK-SSLSRIPQVITDLLPSLQKLSLDNEGSKLVVLNNLKKMVNL 588

Query: 521  KHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEI 700
            K L L    L  +P    SL  L  LDL  NNL       +F +L  L  L L  N+   
Sbjct: 589  KSLELISCDLERIPHSIFSLNNLHELDLRENNLKTVEEIISFQHLQNLSCLKLWHNNIAY 648

Query: 701  LPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNLDLTGQK 880
            +P  IG L+ L+ LSL  N++ +LP ++   T+L  L +  N LT +P E+  L      
Sbjct: 649  IPAQIGALSNLEQLSLDHNNIENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYL---SNL 705

Query: 881  QIFKAENN 904
            Q F   NN
Sbjct: 706  QYFAVTNN 713


>ref|NP_001193082.1| protein LAP2 [Bos taurus].
          Length = 1372

 Score =  102 bits (255), Expect = 5e-22
 Identities = 74/196 (37%), Positives = 94/196 (47%), Gaps = 22/196 (11%)
 Frame = +2

Query: 380 ITQLVLSHNKLTTVPPNIAEL-KNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNT 556
           +T L  SH  L  VP  I    K LE L    NQIEELP Q+ + Q L  L+L  N L  
Sbjct: 24  VTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTA 83

Query: 557 LPRGFGSLPALEVLDLTYNNLSE---------------------NSLPGNFFYLTTLRAL 673
           LP    +L  L  LD++ N + E                     + LP  F  L  L  L
Sbjct: 84  LPASIANLINLRELDVSKNGIQEFPENIKNCKVLTVVEASVNPISKLPDGFSQLLNLTQL 143

Query: 674 YLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPEL 853
           YL+D   E LP + G+LTKLQIL LR+N L  LPK +  LTQL+ L +  N  T +P  L
Sbjct: 144 YLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVL 203

Query: 854 GNLDLTGQKQIFKAEN 901
               L+G K+ +   N
Sbjct: 204 E--QLSGLKEFWMDGN 217



 Score =  100 bits (250), Expect = 2e-21
 Identities = 60/167 (35%), Positives = 92/167 (55%)
 Frame = +2

Query: 362 LFTLAHITQLVLSHNKLTTVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGM 541
           LF    + +L L  N LT +P +IA L NL  L+   N I+E P  I + + L  +   +
Sbjct: 65  LFNCQSLHKLSLPDNDLTALPASIANLINLRELDVSKNGIQEFPENIKNCKVLTVVEASV 124

Query: 542 NRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGK 721
           N ++ LP GF  L  L +  L  N+     LP NF  LT L+ L L +N  ++LP  + +
Sbjct: 125 NPISKLPDGFSQL--LNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNR 182

Query: 722 LTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNL 862
           LT+L+ L L  N+   +P+ + +L+ LKE  + GNRLT +P  +G+L
Sbjct: 183 LTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDGNRLTFIPGFIGSL 229



 Score = 96.7 bits (239), Expect = 4e-20
 Identities = 54/159 (33%), Positives = 89/159 (55%)
 Frame = +2

Query: 368 TLAHITQLVLSHNKLTTVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNR 547
           +L  +T L +S N +  V   I+  +NL+ L   +N +++LP  I SL+ +  L +  N+
Sbjct: 228 SLKQLTYLDISKNNIEMVEEGISGCENLQDLLLSSNSLQQLPETIGSLKNVTTLKIDENQ 287

Query: 548 LNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLT 727
           L  LP   G L ++E LD ++N L   +LP +   LT +R      N  + LPP+IG   
Sbjct: 288 LMYLPDSIGGLVSIEELDCSFNELE--ALPSSIGQLTNIRTFAADHNYLQQLPPEIGSWK 345

Query: 728 KLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLP 844
            + +L L  N L +LP+E+G++ +LK +++  NRL  LP
Sbjct: 346 NITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNLP 384



 Score = 87.0 bits (214), Expect = 3e-17
 Identities = 61/203 (30%), Positives = 98/203 (48%)
 Frame = +2

Query: 254 VMSKSLKKLVEESREKNQPEVDMSDRGISNMLDVNGLFTLAHITQLVLSHNKLTTVPPNI 433
           ++ K++ +L +  R      +D+     + + +V  L  L+ + +  +  N+LT +P  I
Sbjct: 175 MLPKTMNRLTQLER------LDLGSNEFTEVPEV--LEQLSGLKEFWMDGNRLTFIPGFI 226

Query: 434 AELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYN 613
             LK L  L+   N IE +   IS  + L+ L L  N L  LP   GSL  +  L +  N
Sbjct: 227 GSLKQLTYLDISKNNIEMVEEGISGCENLQDLLLSSNSLQQLPETIGSLKNVTTLKIDEN 286

Query: 614 NLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGEL 793
            L    LP +   L ++  L  S N+ E LP  IG+LT ++  +   N L  LP EIG  
Sbjct: 287 QLMY--LPDSIGGLVSIEELDCSFNELEALPSSIGQLTNIRTFAADHNYLQQLPPEIGSW 344

Query: 794 TQLKELHIQGNRLTVLPPELGNL 862
             +  L +  N+L  LP E+G++
Sbjct: 345 KNITVLFLHSNKLETLPEEMGDM 367



 Score = 84.3 bits (207), Expect = 2e-16
 Identities = 68/226 (30%), Positives = 98/226 (43%), Gaps = 44/226 (19%)
 Frame = +2

Query: 314 VDMSDRGISNMLDVNGLFTLAHITQLVLSHNKLTTVPPNIAELKNLEVLNFFNNQIEELP 493
           V+ S   IS + D  G   L ++TQL L+   L  +P N   L  L++L    NQ++ LP
Sbjct: 120 VEASVNPISKLPD--GFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLP 177

Query: 494 TQISSLQKLKHLNLGMN-----------------------RLNTLPRGFGSLPALEVLDL 604
             ++ L +L+ L+LG N                       RL  +P   GSL  L  LD+
Sbjct: 178 KTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDGNRLTFIPGFIGSLKQLTYLDI 237

Query: 605 TYNN------------------LSENSL---PGNFFYLTTLRALYLSDNDFEILPPDIGK 721
           + NN                  LS NSL   P     L  +  L + +N    LP  IG 
Sbjct: 238 SKNNIEMVEEGISGCENLQDLLLSSNSLQQLPETIGSLKNVTTLKIDENQLMYLPDSIGG 297

Query: 722 LTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGN 859
           L  ++ L    N+L +LP  IG+LT ++      N L  LPPE+G+
Sbjct: 298 LVSIEELDCSFNELEALPSSIGQLTNIRTFAADHNYLQQLPPEIGS 343



 Score = 69.7 bits (169), Expect = 5e-12
 Identities = 59/191 (30%), Positives = 94/191 (49%), Gaps = 5/191 (2%)
 Frame = +2

Query: 242 LPFTVMSKSLKKLVEE--SREKNQPEVDMSDRGISNMLDVNGLFTLAHITQLVLSHNKLT 415
           L +  +SK+  ++VEE  S  +N  ++ +S   +  + +  G  +L ++T L +  N+L 
Sbjct: 232 LTYLDISKNNIEMVEEGISGCENLQDLLLSSNSLQQLPETIG--SLKNVTTLKIDENQLM 289

Query: 416 TVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEV 595
            +P +I  L ++E L+   N++E LP+ I  L  ++      N L  LP   GS   + V
Sbjct: 290 YLPDSIGGLVSIEELDCSFNELEALPSSIGQLTNIRTFAADHNYLQQLPPEIGSWKNITV 349

Query: 596 LDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDND---LI 766
           L L  N L   +LP     +  L+ + LSDN  + LP    KL +L  + L DN    LI
Sbjct: 350 LFLHSNKLE--TLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQSKPLI 407

Query: 767 SLPKEIGELTQ 799
            L KE    TQ
Sbjct: 408 PLQKETDSETQ 418


  Database: RefSeq49_BP.fasta
    Posted date:  Oct 17, 2011  1:42 PM
  Number of letters in database: 17,681,374
  Number of sequences in database:  33,088
  
Lambda     K      H
   0.318    0.134    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 33088
Number of Hits to DB: 49,239,018
Number of extensions: 1473009
Number of successful extensions: 6663
Number of sequences better than 1.0e-05: 146
Number of HSP's gapped: 5978
Number of HSP's successfully gapped: 341
Length of query: 402
Length of database: 17,681,374
Length adjustment: 104
Effective length of query: 298
Effective length of database: 14,240,222
Effective search space: 4243586156
Effective search space used: 4243586156
Neighboring words threshold: 12
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 35 (18.1 bits)

BLASTX 2.2.24 [Aug-08-2010]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= 20110601C-000824
         (1206 letters)

Database: RefSeq49_CP.fasta 
           33,336 sequences; 18,874,504 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

Alignment   gi|XP_535177.1| PREDICTED: similar to Ras suppressor protein 1 ...   534   e-152
Alignment   gi|XP_547338.2| PREDICTED: similar to leucine rich repeat conta...   113   3e-25
Alignment   gi|XP_538968.2| PREDICTED: similar to Leucine-rich repeat-conta...   108   1e-23
Alignment   gi|XP_861419.1| PREDICTED: similar to Leucine-rich repeat-conta...   108   1e-23
Alignment   gi|XP_548430.2| PREDICTED: similar to Leucine-rich repeat-conta...   108   1e-23
Alignment   gi|XP_867160.1| PREDICTED: similar to leucine rich repeat conta...   107   3e-23
Alignment   gi|XP_547288.2| PREDICTED: similar to leucine rich repeat conta...   107   3e-23
Alignment   gi|XP_532819.2| PREDICTED: similar to malignant fibrous histioc...   106   4e-23
Alignment   gi|XP_851476.1| PREDICTED: similar to leucine-rich repeats and ...   106   5e-23
Alignment   gi|XP_549199.2| PREDICTED: similar to leucine-rich repeats and ...   106   5e-23

>ref|XP_535177.1| PREDICTED: similar to Ras suppressor protein 1 [Canis familiaris].
          Length = 277

 Score =  534 bits (1376), Expect = e-152
 Identities = 267/274 (97%), Positives = 272/274 (99%)
 Frame = +2

Query: 257  MSKSLKKLVEESREKNQPEVDMSDRGISNMLDVNGLFTLAHITQLVLSHNKLTTVPPNIA 436
            MSKSLKKLVEESREKNQPEVDMSDRGISNMLDVNGLF+L+HITQLVLSHNKLTTVPPNIA
Sbjct: 1    MSKSLKKLVEESREKNQPEVDMSDRGISNMLDVNGLFSLSHITQLVLSHNKLTTVPPNIA 60

Query: 437  ELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNN 616
            ELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNN
Sbjct: 61   ELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNN 120

Query: 617  LSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELT 796
            L+ENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELT
Sbjct: 121  LNENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELT 180

Query: 797  QLKELHIQGNRLTVLPPELGNLDLTGQKQIFKAENNPWVTPIADQFQLGVSHVFEYIRSE 976
            QLKELHIQGNRLTVLPPELGNLDLTGQKQ+FKAENNPWVTPIADQFQLGVSHVFEYIRSE
Sbjct: 181  QLKELHIQGNRLTVLPPELGNLDLTGQKQVFKAENNPWVTPIADQFQLGVSHVFEYIRSE 240

Query: 977  TYKYLYGRHMQANPEPPE*NNDTSKKISRKPLTA 1078
            TYKYLYGRHMQANPEPP+ NND SKKISRKPLTA
Sbjct: 241  TYKYLYGRHMQANPEPPKKNNDKSKKISRKPLTA 274


>ref|XP_547338.2| PREDICTED: similar to leucine rich repeat containing 40 [Canis
           familiaris].
          Length = 555

 Score =  113 bits (283), Expect = 3e-25
 Identities = 74/207 (35%), Positives = 113/207 (54%), Gaps = 1/207 (0%)
 Frame = +2

Query: 359 GLFTLAHITQLVLSHNKLTTVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLG 538
           G   L ++  L +S+N+LTTVP + + L +L  LN  +NQ++ LP +IS +++LKHL+  
Sbjct: 122 GFEQLFNLEDLDISNNRLTTVPASFSSLSSLVRLNISSNQLKSLPVEISGMKRLKHLDCN 181

Query: 539 MNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPD-I 715
            N L T+P    ++ +LE+L L  N L    LP  F     L+ L++ +N  EIL P+ +
Sbjct: 182 SNLLETVPPELANMESLELLYLRRNKL--RFLP-EFPSCRLLKELHVGENQIEILGPEHL 238

Query: 716 GKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNLDLTGQKQIFKA 895
             L  + +L LRDN L S+P EI  L  L+ L +  N ++ LP  LG L L    +    
Sbjct: 239 KHLNSILVLDLRDNKLRSVPDEITLLQSLERLDLSNNDISSLPCSLGKLPL----KFLAL 294

Query: 896 ENNPWVTPIADQFQLGVSHVFEYIRSE 976
           E NP  T   +    G   V +Y+RS+
Sbjct: 295 EGNPLRTIRREIINKGTQEVLKYLRSK 321



 Score = 98.2 bits (243), Expect = 1e-20
 Identities = 61/171 (35%), Positives = 101/171 (59%), Gaps = 2/171 (1%)
 Frame = +2

Query: 338 SNMLD--VNGLFTLAHITQLVLSHNKLTTVPPNIAELKNLEVLNFFNNQIEELPTQISSL 511
           SN L    + L  L  +T L +  N+LT++P  I EL+NL+ LN  +N+++ LP +I++L
Sbjct: 44  SNQLQSLTDDLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLQILPEEITNL 103

Query: 512 QKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDND 691
           + LK L L  N L  +P GF  L  LE LD++ N L+  ++P +F  L++L  L +S N 
Sbjct: 104 RNLKGLYLQHNELTRIPEGFEQLFNLEDLDISNNRLT--TVPASFSSLSSLVRLNISSNQ 161

Query: 692 FEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLP 844
            + LP +I  + +L+ L    N L ++P E+  +  L+ L+++ N+L  LP
Sbjct: 162 LKSLPVEISGMKRLKHLDCNSNLLETVPPELANMESLELLYLRRNKLRFLP 212



 Score = 95.1 bits (235), Expect = 1e-19
 Identities = 57/162 (35%), Positives = 89/162 (54%)
 Frame = +2

Query: 380 ITQLVLSHNKLTTVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTL 559
           +T+L+LS N+L ++  ++  L  L VL+  +NQ+  LP+ I  L+ L+ LN+  N+L  L
Sbjct: 37  LTKLILSSNQLQSLTDDLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLQIL 96

Query: 560 PRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQI 739
           P    +L  L+ L L +N L+   +P  F  L  L  L +S+N    +P     L+ L  
Sbjct: 97  PEEITNLRNLKGLYLQHNELTR--IPEGFEQLFNLEDLDISNNRLTTVPASFSSLSSLVR 154

Query: 740 LSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNLD 865
           L++  N L SLP EI  + +LK L    N L  +PPEL N++
Sbjct: 155 LNISSNQLKSLPVEISGMKRLKHLDCNSNLLETVPPELANME 196



 Score = 78.6 bits (192), Expect = 1e-14
 Identities = 50/155 (32%), Positives = 82/155 (52%), Gaps = 2/155 (1%)
 Frame = +2

Query: 380 ITQLVLSHNKLTTVPPNIAELKNL-EVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNT 556
           IT +  S N+L  +P  I ELK +   +N   N++  +  ++  LQKL  L+L  N LN+
Sbjct: 380 ITSVNFSKNQLCEIPKRIVELKEMVSDVNLSFNKLSFISLELCMLQKLTFLDLRNNFLNS 439

Query: 557 LPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGK-LTKL 733
           LP    SL  L+ ++L++N      LP   +++ TL  + +S+N    + P   K +  L
Sbjct: 440 LPEEMESLIRLQTINLSFNRFK--ILPDVLYHIPTLETILISNNQVGSVDPQKMKAMENL 497

Query: 734 QILSLRDNDLISLPKEIGELTQLKELHIQGNRLTV 838
             L L++NDL+ +P E+G    L+ L + GN   V
Sbjct: 498 ITLDLQNNDLLQIPPELGNCVNLRTLLLDGNPFRV 532



 Score = 76.3 bits (186), Expect = 6e-14
 Identities = 58/196 (29%), Positives = 97/196 (49%), Gaps = 5/196 (2%)
 Frame = +2

Query: 398 SHNKLTTVPPNIAELKNLEVL---NFFNNQIEELPTQISSLQKL-KHLNLGMNRLNTLPR 565
           S  + T +P  + +     ++   NF  NQ+ E+P +I  L+++   +NL  N+L+ +  
Sbjct: 360 SDKQTTLIPDEVFDAVKSNIITSVNFSKNQLCEIPKRIVELKEMVSDVNLSFNKLSFISL 419

Query: 566 GFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILS 745
               L  L  LDL  N L  NSLP     L  L+ + LS N F+ILP  +  +  L+ + 
Sbjct: 420 ELCMLQKLTFLDLRNNFL--NSLPEEMESLIRLQTINLSFNRFKILPDVLYHIPTLETIL 477

Query: 746 LRDNDLISL-PKEIGELTQLKELHIQGNRLTVLPPELGNLDLTGQKQIFKAENNPWVTPI 922
           + +N + S+ P+++  +  L  L +Q N L  +PPELGN       +    + NP+  P 
Sbjct: 478 ISNNQVGSVDPQKMKAMENLITLDLQNNDLLQIPPELGN---CVNLRTLLLDGNPFRVPR 534

Query: 923 ADQFQLGVSHVFEYIR 970
           A     G + + EY+R
Sbjct: 535 AAILMKGTAAILEYLR 550



 Score = 55.8 bits (133), Expect = 8e-08
 Identities = 29/69 (42%), Positives = 40/69 (57%)
 Frame = +2

Query: 656 TTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLT 835
           T L  L LS N  + L  D+  L  L +L + DN L SLP  I EL  L++L++  N+L 
Sbjct: 35  TDLTKLILSSNQLQSLTDDLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLQ 94

Query: 836 VLPPELGNL 862
           +LP E+ NL
Sbjct: 95  ILPEEITNL 103


>ref|XP_538968.2| PREDICTED: similar to Leucine-rich repeat-containing protein 1 (LAP
           and no PDZ protein) (LANO adapter protein) [Canis
           familiaris].
          Length = 712

 Score =  108 bits (269), Expect = 1e-23
 Identities = 72/196 (36%), Positives = 101/196 (51%), Gaps = 6/196 (3%)
 Frame = +2

Query: 311 EVDMSDRGISNMLDVNGLFTLAHITQLVLSHNKLTTVPPNIAELKNLEVLNFFNNQIEEL 490
           E+D+ +  I N+ +  G   L H+  L L  N+L+ +P  I  LKNL  L+   N++E L
Sbjct: 366 ELDLGNNEIYNLPESIG--ALLHLKDLWLDGNQLSELPQEIGNLKNLLCLDVSENRLERL 423

Query: 491 PTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRA 670
           P +IS L  L  L +  N L  +P G G L  L +L +  N L++  LP       +L  
Sbjct: 424 PEEISGLTSLTDLVISQNLLEMIPDGIGKLKKLSILKVDQNRLTQ--LPEAVGDCESLTE 481

Query: 671 LYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPE 850
           L L++N    LP  IGKL KL  L+   N L+SLPKEIG    L    ++ NRLT LP E
Sbjct: 482 LVLTENQLLTLPKSIGKLKKLSNLNADRNKLVSLPKEIGGCCSLTVFCVRDNRLTRLPAE 541

Query: 851 LGN------LDLTGQK 880
           +        LD+ G +
Sbjct: 542 VSQATELHVLDVAGNR 557



 Score =  106 bits (264), Expect = 5e-23
 Identities = 65/164 (39%), Positives = 92/164 (56%)
 Frame = +2

Query: 371 LAHITQLVLSHNKLTTVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRL 550
           L ++  L L  N LT +P ++ +L+ LE L+  NN+I  LP  I +L  LK L L  N+L
Sbjct: 338 LYNLASLELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLPESIGALLHLKDLWLDGNQL 397

Query: 551 NTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTK 730
           + LP+  G+L  L  LD++ N L    LP     LT+L  L +S N  E++P  IGKL K
Sbjct: 398 SELPQEIGNLKNLLCLDVSENRLER--LPEEISGLTSLTDLVISQNLLEMIPDGIGKLKK 455

Query: 731 LQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNL 862
           L IL +  N L  LP+ +G+   L EL +  N+L  LP  +G L
Sbjct: 456 LSILKVDQNRLTQLPEAVGDCESLTELVLTENQLLTLPKSIGKL 499



 Score =  102 bits (255), Expect = 6e-22
 Identities = 66/180 (36%), Positives = 96/180 (53%), Gaps = 7/180 (3%)
 Frame = +2

Query: 344 MLDVNGL-------FTLAHITQLVLSHNKLTTVPPNIAELKNLEVLNFFNNQIEELPTQI 502
           +LD N L       F L  + +L LS N++  +PP IA    L  L+   N I E+P  I
Sbjct: 230 LLDANQLRELPEQFFQLVKLRKLGLSDNEIQRLPPEIANFMQLVELDVSRNDIPEIPESI 289

Query: 503 SSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLS 682
           S  + L+  +   N L  LP  F  L  L  L +  N++S  SLP N   L  L +L L 
Sbjct: 290 SFCKALQIADFSGNPLTRLPESFPELQNLTCLSV--NDISLQSLPENIGNLYNLASLELR 347

Query: 683 DNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNL 862
           +N    LP  + +L +L+ L L +N++ +LP+ IG L  LK+L + GN+L+ LP E+GNL
Sbjct: 348 ENLLTYLPDSLTQLRRLEELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQEIGNL 407



 Score = 82.8 bits (203), Expect = 6e-16
 Identities = 60/191 (31%), Positives = 88/191 (46%), Gaps = 1/191 (0%)
 Frame = +2

Query: 299 KNQPEVDMSDRGISNMLD-VNGLFTLAHITQLVLSHNKLTTVPPNIAELKNLEVLNFFNN 475
           KN   +D+S+  +  + + ++GL +L   T LV+S N L  +P  I +LK L +L    N
Sbjct: 408 KNLLCLDVSENRLERLPEEISGLTSL---TDLVISQNLLEMIPDGIGKLKKLSILKVDQN 464

Query: 476 QIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYL 655
           ++ +LP  +   + L  L L  N+L TLP+  G L  L  L+   N L            
Sbjct: 465 RLTQLPEAVGDCESLTELVLTENQLLTLPKSIGKLKKLSNLNADRNKLVS---------- 514

Query: 656 TTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLT 835
                          LP +IG    L +  +RDN L  LP E+ + T+L  L + GNRL 
Sbjct: 515 ---------------LPKEIGGCCSLTVFCVRDNRLTRLPAEVSQATELHVLDVAGNRLL 559

Query: 836 VLPPELGNLDL 868
            LP  L  L L
Sbjct: 560 HLPLSLTALKL 570


>ref|XP_861419.1| PREDICTED: similar to Leucine-rich repeat-containing protein 8
            isoform 2 [Canis familiaris].
          Length = 790

 Score =  108 bits (269), Expect = 1e-23
 Identities = 67/186 (36%), Positives = 100/186 (53%), Gaps = 2/186 (1%)
 Frame = +2

Query: 302  NQPEVDMSDRGISNMLDVNGLFTLAHITQLVLSHNKLTTVPPNIAELKNLEVLNFFNNQI 481
            N  E+D+ D  +  + ++     L  +T L L +N +  +P  I  L NLE L    N+I
Sbjct: 595  NLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKI 654

Query: 482  EELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTT 661
            E++PTQ+   +KL++L+L  N L  LP   G L  L+ L +T N +   +LP   F    
Sbjct: 655  EKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAVTANRI--EALPPELFQCRK 712

Query: 662  LRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKE--LHIQGNRLT 835
            LRAL+L +N  + LP  +G+LT L  + LR N L  LP E+GE   LK   L ++ +   
Sbjct: 713  LRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPLLKRSGLVVEEDLFN 772

Query: 836  VLPPEL 853
             LPPE+
Sbjct: 773  TLPPEV 778


>ref|XP_548430.2| PREDICTED: similar to Leucine-rich repeat-containing protein 8
            isoform 1 [Canis familiaris].
          Length = 810

 Score =  108 bits (269), Expect = 1e-23
 Identities = 67/186 (36%), Positives = 100/186 (53%), Gaps = 2/186 (1%)
 Frame = +2

Query: 302  NQPEVDMSDRGISNMLDVNGLFTLAHITQLVLSHNKLTTVPPNIAELKNLEVLNFFNNQI 481
            N  E+D+ D  +  + ++     L  +T L L +N +  +P  I  L NLE L    N+I
Sbjct: 615  NLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKI 674

Query: 482  EELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTT 661
            E++PTQ+   +KL++L+L  N L  LP   G L  L+ L +T N +   +LP   F    
Sbjct: 675  EKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAVTANRI--EALPPELFQCRK 732

Query: 662  LRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKE--LHIQGNRLT 835
            LRAL+L +N  + LP  +G+LT L  + LR N L  LP E+GE   LK   L ++ +   
Sbjct: 733  LRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPLLKRSGLVVEEDLFN 792

Query: 836  VLPPEL 853
             LPPE+
Sbjct: 793  TLPPEV 798


>ref|XP_867160.1| PREDICTED: similar to leucine rich repeat containing 5 isoform 2
            [Canis familiaris].
          Length = 847

 Score =  107 bits (266), Expect = 3e-23
 Identities = 66/186 (35%), Positives = 101/186 (54%), Gaps = 2/186 (1%)
 Frame = +2

Query: 302  NQPEVDMSDRGISNMLDVNGLFTLAHITQLVLSHNKLTTVPPNIAELKNLEVLNFFNNQI 481
            N  E+D+    I  + ++     L  +T L L HNK+ T+PP+I  +KNLE L F NN++
Sbjct: 648  NLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIATIPPSITHVKNLESLYFSNNKL 707

Query: 482  EELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTT 661
            E LP  + SLQKL+ L++  N ++ +P   G L  L+ L +T N +  + LP   F    
Sbjct: 708  ESLPVAVFSLQKLRCLDVSYNNISVIPIEIGLLQNLQHLHITGNKV--DLLPKQLFKCVK 765

Query: 662  LRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKE--LHIQGNRLT 835
            LR L L  N    L   IG+L++L  L L+ N L  LP ++G+   LK+  L ++ +   
Sbjct: 766  LRTLNLGQNCITFLSEKIGQLSQLTQLELKGNCLDRLPAQLGQCRLLKKSGLVVEDHLFD 825

Query: 836  VLPPEL 853
             LP E+
Sbjct: 826  TLPLEV 831



 Score = 80.9 bits (198), Expect = 2e-15
 Identities = 57/185 (30%), Positives = 97/185 (52%), Gaps = 2/185 (1%)
 Frame = +2

Query: 338  SNMLDVNGLFTLAHITQLVLSHNKLTTVPPNIAELKNLEVLNFFNNQIEELPTQIS--SL 511
            + +L +N L  + ++ +L L + +L  +P  I  L NL+ L+  +N I  +   IS   L
Sbjct: 612  TKLLVLNSLKKMMNVAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHL 671

Query: 512  QKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDND 691
            ++L  L L  N++ T+P     +  LE L  + N L   SLP   F L  LR L +S N+
Sbjct: 672  KRLTCLKLWHNKIATIPPSITHVKNLESLYFSNNKLE--SLPVAVFSLQKLRCLDVSYNN 729

Query: 692  FEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNLDLT 871
              ++P +IG L  LQ L +  N +  LPK++ +  +L+ L++  N +T L  ++G L   
Sbjct: 730  ISVIPIEIGLLQNLQHLHITGNKVDLLPKQLFKCVKLRTLNLGQNCITFLSEKIGQLSQL 789

Query: 872  GQKQI 886
             Q ++
Sbjct: 790  TQLEL 794



 Score = 66.6 bits (161), Expect = 4e-11
 Identities = 62/201 (30%), Positives = 97/201 (48%), Gaps = 16/201 (7%)
 Frame = +2

Query: 338  SNMLDVNGLFTLAHITQLVLSHNKLTTVPPNIAELK-NLEVLNFFNNQIEELPTQISSLQ 514
            + M+ +  L  L H+  L +  N LT VP NI ++  +L  L   N+  + L   ++SL+
Sbjct: 565  NKMIGLESLRELRHLKILHVKSN-LTKVPSNITDVAPHLTKLVIHNDGTKLLV--LNSLK 621

Query: 515  KLKH---LNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSD 685
            K+ +   L L    L  +P    SL  L+ LDL  NN+       +F +L  L  L L  
Sbjct: 622  KMMNVAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWH 681

Query: 686  NDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELG--- 856
            N    +PP I  +  L+ L   +N L SLP  +  L +L+ L +  N ++V+P E+G   
Sbjct: 682  NKIATIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISVIPIEIGLLQ 741

Query: 857  ---NLDLTGQ------KQIFK 892
               +L +TG       KQ+FK
Sbjct: 742  NLQHLHITGNKVDLLPKQLFK 762


>ref|XP_547288.2| PREDICTED: similar to leucine rich repeat containing 5 isoform 1
            [Canis familiaris].
          Length = 858

 Score =  107 bits (266), Expect = 3e-23
 Identities = 66/186 (35%), Positives = 101/186 (54%), Gaps = 2/186 (1%)
 Frame = +2

Query: 302  NQPEVDMSDRGISNMLDVNGLFTLAHITQLVLSHNKLTTVPPNIAELKNLEVLNFFNNQI 481
            N  E+D+    I  + ++     L  +T L L HNK+ T+PP+I  +KNLE L F NN++
Sbjct: 659  NLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIATIPPSITHVKNLESLYFSNNKL 718

Query: 482  EELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTT 661
            E LP  + SLQKL+ L++  N ++ +P   G L  L+ L +T N +  + LP   F    
Sbjct: 719  ESLPVAVFSLQKLRCLDVSYNNISVIPIEIGLLQNLQHLHITGNKV--DLLPKQLFKCVK 776

Query: 662  LRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKE--LHIQGNRLT 835
            LR L L  N    L   IG+L++L  L L+ N L  LP ++G+   LK+  L ++ +   
Sbjct: 777  LRTLNLGQNCITFLSEKIGQLSQLTQLELKGNCLDRLPAQLGQCRLLKKSGLVVEDHLFD 836

Query: 836  VLPPEL 853
             LP E+
Sbjct: 837  TLPLEV 842



 Score = 80.9 bits (198), Expect = 2e-15
 Identities = 57/185 (30%), Positives = 97/185 (52%), Gaps = 2/185 (1%)
 Frame = +2

Query: 338  SNMLDVNGLFTLAHITQLVLSHNKLTTVPPNIAELKNLEVLNFFNNQIEELPTQIS--SL 511
            + +L +N L  + ++ +L L + +L  +P  I  L NL+ L+  +N I  +   IS   L
Sbjct: 623  TKLLVLNSLKKMMNVAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHL 682

Query: 512  QKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDND 691
            ++L  L L  N++ T+P     +  LE L  + N L   SLP   F L  LR L +S N+
Sbjct: 683  KRLTCLKLWHNKIATIPPSITHVKNLESLYFSNNKLE--SLPVAVFSLQKLRCLDVSYNN 740

Query: 692  FEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNLDLT 871
              ++P +IG L  LQ L +  N +  LPK++ +  +L+ L++  N +T L  ++G L   
Sbjct: 741  ISVIPIEIGLLQNLQHLHITGNKVDLLPKQLFKCVKLRTLNLGQNCITFLSEKIGQLSQL 800

Query: 872  GQKQI 886
             Q ++
Sbjct: 801  TQLEL 805



 Score = 66.6 bits (161), Expect = 4e-11
 Identities = 62/201 (30%), Positives = 97/201 (48%), Gaps = 16/201 (7%)
 Frame = +2

Query: 338  SNMLDVNGLFTLAHITQLVLSHNKLTTVPPNIAELK-NLEVLNFFNNQIEELPTQISSLQ 514
            + M+ +  L  L H+  L +  N LT VP NI ++  +L  L   N+  + L   ++SL+
Sbjct: 576  NKMIGLESLRELRHLKILHVKSN-LTKVPSNITDVAPHLTKLVIHNDGTKLLV--LNSLK 632

Query: 515  KLKH---LNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSD 685
            K+ +   L L    L  +P    SL  L+ LDL  NN+       +F +L  L  L L  
Sbjct: 633  KMMNVAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWH 692

Query: 686  NDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELG--- 856
            N    +PP I  +  L+ L   +N L SLP  +  L +L+ L +  N ++V+P E+G   
Sbjct: 693  NKIATIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISVIPIEIGLLQ 752

Query: 857  ---NLDLTGQ------KQIFK 892
               +L +TG       KQ+FK
Sbjct: 753  NLQHLHITGNKVDLLPKQLFK 773


>ref|XP_532819.2| PREDICTED: similar to malignant fibrous histiocytoma amplified
           sequence 1 [Canis familiaris].
          Length = 1074

 Score =  106 bits (265), Expect = 4e-23
 Identities = 82/241 (34%), Positives = 117/241 (48%), Gaps = 23/241 (9%)
 Frame = +2

Query: 311 EVDMSDRGISNMLDVNGLFTLAHITQLVLSHNKLTTVPPNIAELKNLEVLNFFNNQIEEL 490
           E+D+S   ++++ D   L  L  +  L + HN+LT  P  + +L  LE L+  +N++  L
Sbjct: 194 ELDVSFNRLAHLPD--SLSCLLRLRTLDVDHNQLTAFPRQLLQLAALEELDVSSNRLRGL 251

Query: 491 PTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRA 670
           P  IS+L+ LK L L    L TLP GF  L +LE L L  N L   +LP  F  L  L+ 
Sbjct: 252 PEDISALRALKILWLSGAELGTLPSGFCELASLESLMLDNNGL--RALPAQFSRLQRLKM 309

Query: 671 LYLSDNDFEILPPDIGKLTKLQILSLRDNDLIS-----------------------LPKE 781
           L LS N FE  P  +  L  L+ L L  N L S                       LP  
Sbjct: 310 LNLSSNLFEEFPAALLPLAGLEELYLSRNQLTSVPSLISGLGRLLTLWLDNNRIRYLPDS 369

Query: 782 IGELTQLKELHIQGNRLTVLPPELGNLDLTGQKQIFKAENNPWVTPIADQFQLGVSHVFE 961
           I ELT L+EL +QGN++ VLP   G L   G   ++K ++NP + P  +    G+ ++  
Sbjct: 370 IVELTGLEELVLQGNQIAVLPDNFGQLSRVG---LWKIKDNPLIQPPYEVCMKGIPYIAA 426

Query: 962 Y 964
           Y
Sbjct: 427 Y 427



 Score = 94.7 bits (234), Expect = 2e-19
 Identities = 64/197 (32%), Positives = 102/197 (51%)
 Frame = +2

Query: 311 EVDMSDRGISNMLDVNGLFTLAHITQLVLSHNKLTTVPPNIAELKNLEVLNFFNNQIEEL 490
           E+D+S   +S  L    +  L  + +L LSHN+L  +P  +  L +LE L+   N++  L
Sbjct: 147 ELDVSHNRLS-ALGAEAVSALRELRKLNLSHNQLPALPAQLGALAHLEELDVSFNRLAHL 205

Query: 491 PTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRA 670
           P  +S L +L+ L++  N+L   PR    L ALE LD++ N L    LP +   L  L+ 
Sbjct: 206 PDSLSCLLRLRTLDVDHNQLTAFPRQLLQLAALEELDVSSNRL--RGLPEDISALRALKI 263

Query: 671 LYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPE 850
           L+LS  +   LP    +L  L+ L L +N L +LP +   L +LK L++  N     P  
Sbjct: 264 LWLSGAELGTLPSGFCELASLESLMLDNNGLRALPAQFSRLQRLKMLNLSSNLFEEFPAA 323

Query: 851 LGNLDLTGQKQIFKAEN 901
           L  L L G ++++ + N
Sbjct: 324 L--LPLAGLEELYLSRN 338



 Score = 80.5 bits (197), Expect = 3e-15
 Identities = 58/170 (34%), Positives = 89/170 (52%), Gaps = 5/170 (2%)
 Frame = +2

Query: 371 LAHITQLVLSHNKLTTVPPNIAEL-KNLEVLNFFNNQIEELPTQ-ISSLQKLKHLNLGMN 544
           L  +  LVL  N+   +P  +AEL   L  L+  +N++  L  + +S+L++L+ LNL  N
Sbjct: 118 LCSLRVLVLRRNRFARLPAAVAELGPRLTELDVSHNRLSALGAEAVSALRELRKLNLSHN 177

Query: 545 RLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKL 724
           +L  LP   G+L  LE LD+++N L+   LP +   L  LR L +  N     P  + +L
Sbjct: 178 QLPALPAQLGALAHLEELDVSFNRLAH--LPDSLSCLLRLRTLDVDHNQLTAFPRQLLQL 235

Query: 725 TKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPP---ELGNLD 865
             L+ L +  N L  LP++I  L  LK L + G  L  LP    EL +L+
Sbjct: 236 AALEELDVSSNRLRGLPEDISALRALKILWLSGAELGTLPSGFCELASLE 285


>ref|XP_851476.1| PREDICTED: similar to leucine-rich repeats and calponin homology
           (CH) domain containing 2 isoform 2 [Canis familiaris].
          Length = 742

 Score =  106 bits (264), Expect = 5e-23
 Identities = 90/307 (29%), Positives = 141/307 (45%), Gaps = 9/307 (2%)
 Frame = +2

Query: 74  RGRGVELSSSRCALAPSAGTGRVPGSGAEFAPTECIARRRSEPCGILSFPRPTC*VLPFT 253
           +G GV      C    S+G G   G G   A              ++  P PT    PF 
Sbjct: 5   QGGGVNSGGGGCGGGGSSGGGGAAGGGGGGAGG---GGGGGGGTLVVPIPVPTLFGQPFP 61

Query: 254 VMSKSLKKLVEESREKNQPEVDMSDRGISNMLDVNGL---------FTLAHITQLVLSHN 406
              +     ++        +  + + G S +L ++G          + L   TQ  LS N
Sbjct: 62  NGPQWNPGSLQPQHTVRSLDRALEEAGNSGILSLSGRKLRDFPGSGYDLTDTTQADLSRN 121

Query: 407 KLTTVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPA 586
           + T +P ++     LE LN ++N I+ +P  I +LQ L +LN+  N L+TLP+    LP 
Sbjct: 122 RFTEIPSDVWLFAPLETLNLYHNCIKTIPEAIKNLQMLTYLNISRNLLSTLPKYLFDLP- 180

Query: 587 LEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLI 766
           L+VL ++ N L   S+P     L  L  L +S N+ ++LP  +GKL  L+ L++R N+L 
Sbjct: 181 LKVLVVSNNKLV--SIPEEIGKLKDLMELDISCNEIQVLPQQMGKLHSLRELNIRRNNLH 238

Query: 767 SLPKEIGELTQLKELHIQGNRLTVLPPELGNLDLTGQKQIFKAENNPWVTPIADQFQLGV 946
            LP E+G+L  +K L    N++T +P     L      Q+   +NNP   P A     G 
Sbjct: 239 VLPDELGDLPLVK-LDFSCNKVTEIPVCYRKLH---HLQVMILDNNPLQVPPAQICLKGK 294

Query: 947 SHVFEYI 967
            H+F+Y+
Sbjct: 295 VHIFKYL 301


>ref|XP_549199.2| PREDICTED: similar to leucine-rich repeats and calponin homology
           (CH) domain containing 2 isoform 1 [Canis familiaris].
          Length = 765

 Score =  106 bits (264), Expect = 5e-23
 Identities = 90/307 (29%), Positives = 141/307 (45%), Gaps = 9/307 (2%)
 Frame = +2

Query: 74  RGRGVELSSSRCALAPSAGTGRVPGSGAEFAPTECIARRRSEPCGILSFPRPTC*VLPFT 253
           +G GV      C    S+G G   G G   A              ++  P PT    PF 
Sbjct: 5   QGGGVNSGGGGCGGGGSSGGGGAAGGGGGGAGG---GGGGGGGTLVVPIPVPTLFGQPFP 61

Query: 254 VMSKSLKKLVEESREKNQPEVDMSDRGISNMLDVNGL---------FTLAHITQLVLSHN 406
              +     ++        +  + + G S +L ++G          + L   TQ  LS N
Sbjct: 62  NGPQWNPGSLQPQHTVRSLDRALEEAGNSGILSLSGRKLRDFPGSGYDLTDTTQADLSRN 121

Query: 407 KLTTVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPA 586
           + T +P ++     LE LN ++N I+ +P  I +LQ L +LN+  N L+TLP+    LP 
Sbjct: 122 RFTEIPSDVWLFAPLETLNLYHNCIKTIPEAIKNLQMLTYLNISRNLLSTLPKYLFDLP- 180

Query: 587 LEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLI 766
           L+VL ++ N L   S+P     L  L  L +S N+ ++LP  +GKL  L+ L++R N+L 
Sbjct: 181 LKVLVVSNNKLV--SIPEEIGKLKDLMELDISCNEIQVLPQQMGKLHSLRELNIRRNNLH 238

Query: 767 SLPKEIGELTQLKELHIQGNRLTVLPPELGNLDLTGQKQIFKAENNPWVTPIADQFQLGV 946
            LP E+G+L  +K L    N++T +P     L      Q+   +NNP   P A     G 
Sbjct: 239 VLPDELGDLPLVK-LDFSCNKVTEIPVCYRKLH---HLQVMILDNNPLQVPPAQICLKGK 294

Query: 947 SHVFEYI 967
            H+F+Y+
Sbjct: 295 VHIFKYL 301


  Database: RefSeq49_CP.fasta
    Posted date:  Oct 17, 2011  1:42 PM
  Number of letters in database: 18,874,504
  Number of sequences in database:  33,336
  
Lambda     K      H
   0.318    0.134    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 33336
Number of Hits to DB: 51,540,638
Number of extensions: 1515368
Number of successful extensions: 6619
Number of sequences better than 1.0e-05: 112
Number of HSP's gapped: 6027
Number of HSP's successfully gapped: 270
Length of query: 402
Length of database: 18,874,504
Length adjustment: 105
Effective length of query: 297
Effective length of database: 15,374,224
Effective search space: 4566144528
Effective search space used: 4566144528
Neighboring words threshold: 12
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 35 (18.1 bits)

BLASTX 2.2.24 [Aug-08-2010]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= 20110601C-000824
         (1206 letters)

Database: RefSeq49_HP.fasta 
           32,964 sequences; 18,297,164 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

Alignment   gi|NP_036557.1| ras suppressor protein 1 isoform 1 [Homo sapien...   533   e-151
Alignment   gi|NP_689937.2| ras suppressor protein 1 isoform 2 [Homo sapien...   433   e-121
Alignment   gi|NP_001127951.1| leucine-rich repeat-containing protein 8D [H...   112   9e-25
Alignment   gi|NP_060573.2| leucine-rich repeat-containing protein 8D [Homo...   112   9e-25
Alignment   gi|NP_060684.4| leucine-rich repeat-containing protein 1 [Homo ...   110   3e-24
Alignment   gi|NP_060238.3| leucine-rich repeat-containing protein 40 [Homo...   110   3e-24
Alignment   gi|NP_001120717.1| leucine-rich repeat-containing protein 8A [H...   108   1e-23
Alignment   gi|NP_062540.2| leucine-rich repeat-containing protein 8A [Homo...   108   1e-23
Alignment   gi|NP_001120716.1| leucine-rich repeat-containing protein 8A [H...   108   1e-23
Alignment   gi|NP_056171.2| protein scribble homolog isoform b [Homo sapien...   108   1e-23

>ref|NP_036557.1| ras suppressor protein 1 isoform 1 [Homo sapiens].
          Length = 277

 Score =  533 bits (1372), Expect = e-151
 Identities = 267/274 (97%), Positives = 270/274 (98%)
 Frame = +2

Query: 257  MSKSLKKLVEESREKNQPEVDMSDRGISNMLDVNGLFTLAHITQLVLSHNKLTTVPPNIA 436
            MSKSLKKLVEESREKNQPEVDMSDRGISNMLDVNGLFTL+HITQLVLSHNKLT VPPNIA
Sbjct: 1    MSKSLKKLVEESREKNQPEVDMSDRGISNMLDVNGLFTLSHITQLVLSHNKLTMVPPNIA 60

Query: 437  ELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNN 616
            ELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNN
Sbjct: 61   ELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNN 120

Query: 617  LSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELT 796
            LSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELT
Sbjct: 121  LSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELT 180

Query: 797  QLKELHIQGNRLTVLPPELGNLDLTGQKQIFKAENNPWVTPIADQFQLGVSHVFEYIRSE 976
            QLKELHIQGNRLTVLPPELGNLDLTGQKQ+FKAENNPWVTPIADQFQLGVSHVFEYIRSE
Sbjct: 181  QLKELHIQGNRLTVLPPELGNLDLTGQKQVFKAENNPWVTPIADQFQLGVSHVFEYIRSE 240

Query: 977  TYKYLYGRHMQANPEPPE*NNDTSKKISRKPLTA 1078
            TYKYLYGRHMQANPEPP+ NND SKKISRKPL A
Sbjct: 241  TYKYLYGRHMQANPEPPKKNNDKSKKISRKPLAA 274


>ref|NP_689937.2| ras suppressor protein 1 isoform 2 [Homo sapiens].
          Length = 224

 Score =  433 bits (1114), Expect = e-121
 Identities = 215/220 (97%), Positives = 217/220 (98%)
 Frame = +2

Query: 419  VPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVL 598
            VPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVL
Sbjct: 2    VPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVL 61

Query: 599  DLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPK 778
            DLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPK
Sbjct: 62   DLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPK 121

Query: 779  EIGELTQLKELHIQGNRLTVLPPELGNLDLTGQKQIFKAENNPWVTPIADQFQLGVSHVF 958
            EIGELTQLKELHIQGNRLTVLPPELGNLDLTGQKQ+FKAENNPWVTPIADQFQLGVSHVF
Sbjct: 122  EIGELTQLKELHIQGNRLTVLPPELGNLDLTGQKQVFKAENNPWVTPIADQFQLGVSHVF 181

Query: 959  EYIRSETYKYLYGRHMQANPEPPE*NNDTSKKISRKPLTA 1078
            EYIRSETYKYLYGRHMQANPEPP+ NND SKKISRKPL A
Sbjct: 182  EYIRSETYKYLYGRHMQANPEPPKKNNDKSKKISRKPLAA 221


>ref|NP_001127951.1| leucine-rich repeat-containing protein 8D [Homo sapiens].
          Length = 858

 Score =  112 bits (279), Expect = 9e-25
 Identities = 66/185 (35%), Positives = 102/185 (55%)
 Frame = +2

Query: 302  NQPEVDMSDRGISNMLDVNGLFTLAHITQLVLSHNKLTTVPPNIAELKNLEVLNFFNNQI 481
            N  E+D+    I  + ++     L  +T L L HNK+ T+PP+I  +KNLE L F NN++
Sbjct: 659  NLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKL 718

Query: 482  EELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTT 661
            E LP  + SLQKL+                        LD++YNN+S   +P     L  
Sbjct: 719  ESLPVAVFSLQKLR-----------------------CLDVSYNNIS--MIPIEIGLLQN 753

Query: 662  LRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVL 841
            L+ L+++ N  +ILP  + K  KL+ L+L  N + SLP+++G+L+QL +L ++GN L  L
Sbjct: 754  LQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQLELKGNCLDRL 813

Query: 842  PPELG 856
            P +LG
Sbjct: 814  PAQLG 818



 Score = 81.6 bits (200), Expect = 1e-15
 Identities = 58/185 (31%), Positives = 98/185 (52%), Gaps = 2/185 (1%)
 Frame = +2

Query: 338  SNMLDVNGLFTLAHITQLVLSHNKLTTVPPNIAELKNLEVLNFFNNQIEELPTQIS--SL 511
            + +L +N L  + ++ +L L + +L  +P  I  L NL+ L+  +N I  +   IS   L
Sbjct: 623  TKLLVLNSLKKMMNVAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHL 682

Query: 512  QKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDND 691
            ++L  L L  N++ T+P     +  LE L  + N L   SLP   F L  LR L +S N+
Sbjct: 683  KRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLE--SLPVAVFSLQKLRCLDVSYNN 740

Query: 692  FEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNLDLT 871
              ++P +IG L  LQ L +  N +  LPK++ +  +L+ L++  N +T LP ++G L   
Sbjct: 741  ISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQL 800

Query: 872  GQKQI 886
             Q ++
Sbjct: 801  TQLEL 805



 Score = 70.5 bits (171), Expect = 3e-12
 Identities = 59/199 (29%), Positives = 95/199 (47%), Gaps = 27/199 (13%)
 Frame = +2

Query: 338  SNMLDVNGLFTLAHITQLVLSHNKLTTVPPNIAELK-NLEVLNFFNNQIEELPTQISSLQ 514
            + M+ +  L  L H+  L +  N LT VP NI ++  +L  L   N+  + L   ++SL+
Sbjct: 576  NKMIGLESLRELRHLKILHVKSN-LTKVPSNITDVAPHLTKLVIHNDGTKLLV--LNSLK 632

Query: 515  KLKH---LNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSE-------------------- 625
            K+ +   L L    L  +P    SL  L+ LDL  NN+                      
Sbjct: 633  KMMNVAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWH 692

Query: 626  ---NSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELT 796
                ++P +  ++  L +LY S+N  E LP  +  L KL+ L +  N++  +P EIG L 
Sbjct: 693  NKIVTIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQ 752

Query: 797  QLKELHIQGNRLTVLPPEL 853
             L+ LHI GN++ +LP +L
Sbjct: 753  NLQHLHITGNKVDILPKQL 771


>ref|NP_060573.2| leucine-rich repeat-containing protein 8D [Homo sapiens].
          Length = 858

 Score =  112 bits (279), Expect = 9e-25
 Identities = 66/185 (35%), Positives = 102/185 (55%)
 Frame = +2

Query: 302  NQPEVDMSDRGISNMLDVNGLFTLAHITQLVLSHNKLTTVPPNIAELKNLEVLNFFNNQI 481
            N  E+D+    I  + ++     L  +T L L HNK+ T+PP+I  +KNLE L F NN++
Sbjct: 659  NLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKL 718

Query: 482  EELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTT 661
            E LP  + SLQKL+                        LD++YNN+S   +P     L  
Sbjct: 719  ESLPVAVFSLQKLR-----------------------CLDVSYNNIS--MIPIEIGLLQN 753

Query: 662  LRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVL 841
            L+ L+++ N  +ILP  + K  KL+ L+L  N + SLP+++G+L+QL +L ++GN L  L
Sbjct: 754  LQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQLELKGNCLDRL 813

Query: 842  PPELG 856
            P +LG
Sbjct: 814  PAQLG 818



 Score = 81.6 bits (200), Expect = 1e-15
 Identities = 58/185 (31%), Positives = 98/185 (52%), Gaps = 2/185 (1%)
 Frame = +2

Query: 338  SNMLDVNGLFTLAHITQLVLSHNKLTTVPPNIAELKNLEVLNFFNNQIEELPTQIS--SL 511
            + +L +N L  + ++ +L L + +L  +P  I  L NL+ L+  +N I  +   IS   L
Sbjct: 623  TKLLVLNSLKKMMNVAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHL 682

Query: 512  QKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDND 691
            ++L  L L  N++ T+P     +  LE L  + N L   SLP   F L  LR L +S N+
Sbjct: 683  KRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLE--SLPVAVFSLQKLRCLDVSYNN 740

Query: 692  FEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNLDLT 871
              ++P +IG L  LQ L +  N +  LPK++ +  +L+ L++  N +T LP ++G L   
Sbjct: 741  ISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQL 800

Query: 872  GQKQI 886
             Q ++
Sbjct: 801  TQLEL 805



 Score = 70.5 bits (171), Expect = 3e-12
 Identities = 59/199 (29%), Positives = 95/199 (47%), Gaps = 27/199 (13%)
 Frame = +2

Query: 338  SNMLDVNGLFTLAHITQLVLSHNKLTTVPPNIAELK-NLEVLNFFNNQIEELPTQISSLQ 514
            + M+ +  L  L H+  L +  N LT VP NI ++  +L  L   N+  + L   ++SL+
Sbjct: 576  NKMIGLESLRELRHLKILHVKSN-LTKVPSNITDVAPHLTKLVIHNDGTKLLV--LNSLK 632

Query: 515  KLKH---LNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSE-------------------- 625
            K+ +   L L    L  +P    SL  L+ LDL  NN+                      
Sbjct: 633  KMMNVAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWH 692

Query: 626  ---NSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELT 796
                ++P +  ++  L +LY S+N  E LP  +  L KL+ L +  N++  +P EIG L 
Sbjct: 693  NKIVTIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQ 752

Query: 797  QLKELHIQGNRLTVLPPEL 853
             L+ LHI GN++ +LP +L
Sbjct: 753  NLQHLHITGNKVDILPKQL 771


>ref|NP_060684.4| leucine-rich repeat-containing protein 1 [Homo sapiens].
          Length = 524

 Score =  110 bits (274), Expect = 3e-24
 Identities = 72/196 (36%), Positives = 102/196 (52%), Gaps = 6/196 (3%)
 Frame = +2

Query: 311 EVDMSDRGISNMLDVNGLFTLAHITQLVLSHNKLTTVPPNIAELKNLEVLNFFNNQIEEL 490
           E+D+ +  I N+ +  G   L H+  L L  N+L+ +P  I  LKNL  L+   N++E L
Sbjct: 178 ELDLGNNEIYNLPESIG--ALLHLKDLWLDGNQLSELPQEIGNLKNLLCLDVSENRLERL 235

Query: 491 PTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRA 670
           P +IS L  L  L +  N L T+P G G L  L +L +  N L++  LP       +L  
Sbjct: 236 PEEISGLTSLTDLVISQNLLETIPDGIGKLKKLSILKVDQNRLTQ--LPEAVGECESLTE 293

Query: 671 LYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPE 850
           L L++N    LP  IGKL KL  L+   N L+SLPKEIG    L    ++ NRLT +P E
Sbjct: 294 LVLTENQLLTLPKSIGKLKKLSNLNADRNKLVSLPKEIGGCCSLTVFCVRDNRLTRIPAE 353

Query: 851 LGN------LDLTGQK 880
           +        LD+ G +
Sbjct: 354 VSQATELHVLDVAGNR 369



 Score =  106 bits (265), Expect = 4e-23
 Identities = 66/164 (40%), Positives = 91/164 (55%)
 Frame = +2

Query: 371 LAHITQLVLSHNKLTTVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRL 550
           L ++  L L  N LT +P ++ +L+ LE L+  NN+I  LP  I +L  LK L L  N+L
Sbjct: 150 LYNLASLELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLPESIGALLHLKDLWLDGNQL 209

Query: 551 NTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTK 730
           + LP+  G+L  L  LD++ N L    LP     LT+L  L +S N  E +P  IGKL K
Sbjct: 210 SELPQEIGNLKNLLCLDVSENRLER--LPEEISGLTSLTDLVISQNLLETIPDGIGKLKK 267

Query: 731 LQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNL 862
           L IL +  N L  LP+ +GE   L EL +  N+L  LP  +G L
Sbjct: 268 LSILKVDQNRLTQLPEAVGECESLTELVLTENQLLTLPKSIGKL 311



 Score =  103 bits (257), Expect = 3e-22
 Identities = 66/180 (36%), Positives = 97/180 (53%), Gaps = 7/180 (3%)
 Frame = +2

Query: 344 MLDVNGL-------FTLAHITQLVLSHNKLTTVPPNIAELKNLEVLNFFNNQIEELPTQI 502
           +LD N L       F L  + +L LS N++  +PP IA    L  L+   N+I E+P  I
Sbjct: 42  LLDANQLRELPEQFFQLVKLRKLGLSDNEIQRLPPEIANFMQLVELDVSRNEIPEIPESI 101

Query: 503 SSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLS 682
           S  + L+  +   N L  LP  F  L  L  L +  N++S  SLP N   L  L +L L 
Sbjct: 102 SFCKALQVADFSGNPLTRLPESFPELQNLTCLSV--NDISLQSLPENIGNLYNLASLELR 159

Query: 683 DNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNL 862
           +N    LP  + +L +L+ L L +N++ +LP+ IG L  LK+L + GN+L+ LP E+GNL
Sbjct: 160 ENLLTYLPDSLTQLRRLEELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQEIGNL 219



 Score = 88.6 bits (218), Expect = 1e-17
 Identities = 56/167 (33%), Positives = 88/167 (52%)
 Frame = +2

Query: 356 NGLFTLAHITQLVLSHNKLTTVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNL 535
           + L  L  + +L L +N++  +P +I  L +L+ L    NQ+ ELP +I +L+ L  L++
Sbjct: 168 DSLTQLRRLEELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQEIGNLKNLLCLDV 227

Query: 536 GMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDI 715
             NRL  LP     L +L  L ++ N L   ++P     L  L  L +  N    LP  +
Sbjct: 228 SENRLERLPEEISGLTSLTDLVISQNLL--ETIPDGIGKLKKLSILKVDQNRLTQLPEAV 285

Query: 716 GKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELG 856
           G+   L  L L +N L++LPK IG+L +L  L+   N+L  LP E+G
Sbjct: 286 GECESLTELVLTENQLLTLPKSIGKLKKLSNLNADRNKLVSLPKEIG 332



 Score = 57.0 bits (136), Expect = 3e-08
 Identities = 40/108 (37%), Positives = 57/108 (52%)
 Frame = +2

Query: 380 ITQLVLSHNKLTTVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTL 559
           +T+LVL+ N+L T+P +I +LK L  LN   N++  LP +I     L    +  NRL  +
Sbjct: 291 LTELVLTENQLLTLPKSIGKLKKLSNLNADRNKLVSLPKEIGGCCSLTVFCVRDNRLTRI 350

Query: 560 PRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEIL 703
           P        L VLD+  N L    LP +   L  L+AL+LSDN  + L
Sbjct: 351 PAEVSQATELHVLDVAGNRLLH--LPLSLTAL-KLKALWLSDNQSQPL 395


>ref|NP_060238.3| leucine-rich repeat-containing protein 40 [Homo sapiens].
          Length = 602

 Score =  110 bits (274), Expect = 3e-24
 Identities = 72/207 (34%), Positives = 113/207 (54%), Gaps = 1/207 (0%)
 Frame = +2

Query: 359 GLFTLAHITQLVLSHNKLTTVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLG 538
           G   L+++  L LS+N LTTVP + + L +L  LN  +N+++ LP +I+ +++LKHL+  
Sbjct: 169 GFEQLSNLEDLDLSNNHLTTVPASFSSLSSLVRLNLSSNELKSLPAEINRMKRLKHLDCN 228

Query: 539 MNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPD-I 715
            N L T+P     + +LE+L L  N L    LP  F   + L+ L++ +N  E+L  + +
Sbjct: 229 SNLLETIPPELAGMESLELLYLRRNKL--RFLP-EFPSCSLLKELHVGENQIEMLEAEHL 285

Query: 716 GKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNLDLTGQKQIFKA 895
             L  + +L LRDN L S+P EI  L  L+ L +  N ++ LP  LGNL L    +    
Sbjct: 286 KHLNSILVLDLRDNKLKSVPDEIILLRSLERLDLSNNDISSLPYSLGNLHL----KFLAL 341

Query: 896 ENNPWVTPIADQFQLGVSHVFEYIRSE 976
           E NP  T   +    G   V +Y+RS+
Sbjct: 342 EGNPLRTIRREIISKGTQEVLKYLRSK 368



 Score = 99.4 bits (246), Expect = 6e-21
 Identities = 58/158 (36%), Positives = 98/158 (62%)
 Frame = +2

Query: 371 LAHITQLVLSHNKLTTVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRL 550
           L  +T L +  N+LT++P  I EL+NL+ LN  +N+++ LP +I++L+ LK L L  N L
Sbjct: 104 LPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLKILPEEITNLRNLKCLYLQHNEL 163

Query: 551 NTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTK 730
             +  GF  L  LE LDL+ N+L+  ++P +F  L++L  L LS N+ + LP +I ++ +
Sbjct: 164 TCISEGFEQLSNLEDLDLSNNHLT--TVPASFSSLSSLVRLNLSSNELKSLPAEINRMKR 221

Query: 731 LQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLP 844
           L+ L    N L ++P E+  +  L+ L+++ N+L  LP
Sbjct: 222 LKHLDCNSNLLETIPPELAGMESLELLYLRRNKLRFLP 259



 Score = 97.1 bits (240), Expect = 3e-20
 Identities = 57/162 (35%), Positives = 90/162 (55%)
 Frame = +2

Query: 380 ITQLVLSHNKLTTVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTL 559
           +T+L++S+NKL ++  ++  L  L VL+  +NQ+  LP+ I  L+ L+ LN+  N+L  L
Sbjct: 84  LTKLIISNNKLQSLTDDLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLKIL 143

Query: 560 PRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQI 739
           P    +L  L+ L L +N L+   +   F  L+ L  L LS+N    +P     L+ L  
Sbjct: 144 PEEITNLRNLKCLYLQHNELT--CISEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSLVR 201

Query: 740 LSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNLD 865
           L+L  N+L SLP EI  + +LK L    N L  +PPEL  ++
Sbjct: 202 LNLSSNELKSLPAEINRMKRLKHLDCNSNLLETIPPELAGME 243



 Score = 74.7 bits (182), Expect = 2e-13
 Identities = 47/155 (30%), Positives = 82/155 (52%), Gaps = 2/155 (1%)
 Frame = +2

Query: 380 ITQLVLSHNKLTTVPPNIAELKNL-EVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNT 556
           +T +  S N+L  +P  + ELK +   ++   N++  +  ++  LQKL  L+L  N LN+
Sbjct: 427 VTSINFSKNQLCEIPKRMVELKEMVSDVDLSFNKLSFISLELCVLQKLTFLDLRNNFLNS 486

Query: 557 LPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTK-L 733
           LP    SL  L+ ++L++N      LP   + + TL  + +S+N    + P   K+ + L
Sbjct: 487 LPEEMESLVRLQTINLSFNRFK--MLPEVLYRIFTLETILISNNQVGSVDPQKMKMMENL 544

Query: 734 QILSLRDNDLISLPKEIGELTQLKELHIQGNRLTV 838
             L L++NDL+ +P E+G    L+ L + GN   V
Sbjct: 545 TTLDLQNNDLLQIPPELGNCVNLRTLLLDGNPFRV 579



 Score = 73.2 bits (178), Expect = 5e-13
 Identities = 55/196 (28%), Positives = 98/196 (50%), Gaps = 5/196 (2%)
 Frame = +2

Query: 398 SHNKLTTVPPNIAELKNLEV---LNFFNNQIEELPTQISSLQKL-KHLNLGMNRLNTLPR 565
           S  + T +P  + +     +   +NF  NQ+ E+P ++  L+++   ++L  N+L+ +  
Sbjct: 407 SDKQATLIPDEVFDAVKSNIVTSINFSKNQLCEIPKRMVELKEMVSDVDLSFNKLSFISL 466

Query: 566 GFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILS 745
               L  L  LDL  N L  NSLP     L  L+ + LS N F++LP  + ++  L+ + 
Sbjct: 467 ELCVLQKLTFLDLRNNFL--NSLPEEMESLVRLQTINLSFNRFKMLPEVLYRIFTLETIL 524

Query: 746 LRDNDLISL-PKEIGELTQLKELHIQGNRLTVLPPELGNLDLTGQKQIFKAENNPWVTPI 922
           + +N + S+ P+++  +  L  L +Q N L  +PPELGN       +    + NP+  P 
Sbjct: 525 ISNNQVGSVDPQKMKMMENLTTLDLQNNDLLQIPPELGN---CVNLRTLLLDGNPFRVPR 581

Query: 923 ADQFQLGVSHVFEYIR 970
           A     G + + EY+R
Sbjct: 582 AAILMKGTAAILEYLR 597



 Score = 61.2 bits (147), Expect = 2e-09
 Identities = 61/219 (27%), Positives = 98/219 (44%), Gaps = 21/219 (9%)
 Frame = +2

Query: 344 MLDVNGLFTLAHITQLVLSHNKLTTVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLK 523
           ML+   L  L  I  L L  NKL +VP  I  L++LE L+  NN I  LP  + +L  LK
Sbjct: 279 MLEAEHLKHLNSILVLDLRDNKLKSVPDEIILLRSLERLDLSNNDISSLPYSLGNLH-LK 337

Query: 524 HLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSEN-------------SLPG----NFFY 652
            L L  N L T+ R   S    EVL    + + ++             +LP     N   
Sbjct: 338 FLALEGNPLRTIRREIISKGTQEVLKYLRSKIKDDGPSQSESATETAMTLPSESRVNIHA 397

Query: 653 LTTLRALYLSDNDFEILPPDIGKLTKLQI---LSLRDNDLISLPKEIGELTQL-KELHIQ 820
           + TL+ L  SD    ++P ++    K  I   ++   N L  +PK + EL ++  ++ + 
Sbjct: 398 IITLKILDYSDKQATLIPDEVFDAVKSNIVTSINFSKNQLCEIPKRMVELKEMVSDVDLS 457

Query: 821 GNRLTVLPPELGNLDLTGQKQIFKAENNPWVTPIADQFQ 937
            N+L+ +  EL  L    QK  F    N ++  + ++ +
Sbjct: 458 FNKLSFISLELCVL----QKLTFLDLRNNFLNSLPEEME 492



 Score = 57.0 bits (136), Expect = 3e-08
 Identities = 37/121 (30%), Positives = 64/121 (52%)
 Frame = +2

Query: 500 ISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYL 679
           + + +K   LNL    L+ +P+    +  +++ +    NLS  +    ++  T L  L +
Sbjct: 32  LKAARKSGQLNLSGRNLSEVPQCVWRIN-VDIPEEANQNLSFGATE-RWWEQTDLTKLII 89

Query: 680 SDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGN 859
           S+N  + L  D+  L  L +L + DN L SLP  I EL  L++L++  N+L +LP E+ N
Sbjct: 90  SNNKLQSLTDDLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLKILPEEITN 149

Query: 860 L 862
           L
Sbjct: 150 L 150


>ref|NP_001120717.1| leucine-rich repeat-containing protein 8A [Homo sapiens].
          Length = 810

 Score =  108 bits (270), Expect = 1e-23
 Identities = 67/186 (36%), Positives = 100/186 (53%), Gaps = 2/186 (1%)
 Frame = +2

Query: 302  NQPEVDMSDRGISNMLDVNGLFTLAHITQLVLSHNKLTTVPPNIAELKNLEVLNFFNNQI 481
            N  E+D+ D  +  + ++     L  +T L L +N +  +P  I  L NLE L    N+I
Sbjct: 615  NLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKI 674

Query: 482  EELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTT 661
            E++PTQ+   +KL++L+L  N L  LP   G L  L+ L +T N +   +LP   F    
Sbjct: 675  EKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRI--ETLPPELFQCRK 732

Query: 662  LRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKE--LHIQGNRLT 835
            LRAL+L +N  + LP  +G+LT L  + LR N L  LP E+GE   LK   L ++ +   
Sbjct: 733  LRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPLLKRSGLVVEEDLFN 792

Query: 836  VLPPEL 853
             LPPE+
Sbjct: 793  TLPPEV 798



 Score = 58.9 bits (141), Expect = 9e-09
 Identities = 54/187 (28%), Positives = 80/187 (42%), Gaps = 25/187 (13%)
 Frame = +2

Query: 377  HITQLVLSHNKLTTVPPNIAELKNLEVLNFFNNQIEELPTQISS----LQKLKHLNLGMN 544
            H+T  + + N    V   + ELK L+VL   +N + +LP  ++     LQKL   N G  
Sbjct: 522  HLTGNLSAENNRYIVIDGLRELKRLKVLRLKSN-LSKLPQVVTDVGVHLQKLSINNEGTK 580

Query: 545  R---------------------LNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTT 661
                                  L  +P    SL  L+ +DL  NNL       +F +L  
Sbjct: 581  LIVLNSLKKMANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHR 640

Query: 662  LRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVL 841
            L  L L  N    +P  IG LT L+ L L  N +  +P ++    +L+ L +  N LT L
Sbjct: 641  LTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFL 700

Query: 842  PPELGNL 862
            P ++G L
Sbjct: 701  PADIGLL 707


>ref|NP_062540.2| leucine-rich repeat-containing protein 8A [Homo sapiens].
          Length = 810

 Score =  108 bits (270), Expect = 1e-23
 Identities = 67/186 (36%), Positives = 100/186 (53%), Gaps = 2/186 (1%)
 Frame = +2

Query: 302  NQPEVDMSDRGISNMLDVNGLFTLAHITQLVLSHNKLTTVPPNIAELKNLEVLNFFNNQI 481
            N  E+D+ D  +  + ++     L  +T L L +N +  +P  I  L NLE L    N+I
Sbjct: 615  NLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKI 674

Query: 482  EELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTT 661
            E++PTQ+   +KL++L+L  N L  LP   G L  L+ L +T N +   +LP   F    
Sbjct: 675  EKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRI--ETLPPELFQCRK 732

Query: 662  LRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKE--LHIQGNRLT 835
            LRAL+L +N  + LP  +G+LT L  + LR N L  LP E+GE   LK   L ++ +   
Sbjct: 733  LRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPLLKRSGLVVEEDLFN 792

Query: 836  VLPPEL 853
             LPPE+
Sbjct: 793  TLPPEV 798



 Score = 58.9 bits (141), Expect = 9e-09
 Identities = 54/187 (28%), Positives = 80/187 (42%), Gaps = 25/187 (13%)
 Frame = +2

Query: 377  HITQLVLSHNKLTTVPPNIAELKNLEVLNFFNNQIEELPTQISS----LQKLKHLNLGMN 544
            H+T  + + N    V   + ELK L+VL   +N + +LP  ++     LQKL   N G  
Sbjct: 522  HLTGNLSAENNRYIVIDGLRELKRLKVLRLKSN-LSKLPQVVTDVGVHLQKLSINNEGTK 580

Query: 545  R---------------------LNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTT 661
                                  L  +P    SL  L+ +DL  NNL       +F +L  
Sbjct: 581  LIVLNSLKKMANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHR 640

Query: 662  LRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVL 841
            L  L L  N    +P  IG LT L+ L L  N +  +P ++    +L+ L +  N LT L
Sbjct: 641  LTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFL 700

Query: 842  PPELGNL 862
            P ++G L
Sbjct: 701  PADIGLL 707


>ref|NP_001120716.1| leucine-rich repeat-containing protein 8A [Homo sapiens].
          Length = 810

 Score =  108 bits (270), Expect = 1e-23
 Identities = 67/186 (36%), Positives = 100/186 (53%), Gaps = 2/186 (1%)
 Frame = +2

Query: 302  NQPEVDMSDRGISNMLDVNGLFTLAHITQLVLSHNKLTTVPPNIAELKNLEVLNFFNNQI 481
            N  E+D+ D  +  + ++     L  +T L L +N +  +P  I  L NLE L    N+I
Sbjct: 615  NLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKI 674

Query: 482  EELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTT 661
            E++PTQ+   +KL++L+L  N L  LP   G L  L+ L +T N +   +LP   F    
Sbjct: 675  EKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRI--ETLPPELFQCRK 732

Query: 662  LRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKE--LHIQGNRLT 835
            LRAL+L +N  + LP  +G+LT L  + LR N L  LP E+GE   LK   L ++ +   
Sbjct: 733  LRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPLLKRSGLVVEEDLFN 792

Query: 836  VLPPEL 853
             LPPE+
Sbjct: 793  TLPPEV 798



 Score = 58.9 bits (141), Expect = 9e-09
 Identities = 54/187 (28%), Positives = 80/187 (42%), Gaps = 25/187 (13%)
 Frame = +2

Query: 377  HITQLVLSHNKLTTVPPNIAELKNLEVLNFFNNQIEELPTQISS----LQKLKHLNLGMN 544
            H+T  + + N    V   + ELK L+VL   +N + +LP  ++     LQKL   N G  
Sbjct: 522  HLTGNLSAENNRYIVIDGLRELKRLKVLRLKSN-LSKLPQVVTDVGVHLQKLSINNEGTK 580

Query: 545  R---------------------LNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTT 661
                                  L  +P    SL  L+ +DL  NNL       +F +L  
Sbjct: 581  LIVLNSLKKMANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHR 640

Query: 662  LRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVL 841
            L  L L  N    +P  IG LT L+ L L  N +  +P ++    +L+ L +  N LT L
Sbjct: 641  LTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFL 700

Query: 842  PPELGNL 862
            P ++G L
Sbjct: 701  PADIGLL 707


>ref|NP_056171.2| protein scribble homolog isoform b [Homo sapiens].
          Length = 1630

 Score =  108 bits (270), Expect = 1e-23
 Identities = 74/218 (33%), Positives = 106/218 (48%), Gaps = 21/218 (9%)
 Frame = +2

Query: 311 EVDMSDRGISNMLDVNGLFTLAHITQLVLSHNKLTTVPPNIAELKNLEVLNFFNNQIEEL 490
           ++D+    +  + D  G   L ++ +L L  N+L+ +PP +  L+ L  L+   N++EEL
Sbjct: 178 QLDLGGNDLEVLPDTLG--ALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEEL 235

Query: 491 PTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSE--------------- 625
           P ++  L  L  L L  N L  LP G G L  L +L +  N L E               
Sbjct: 236 PAELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELI 295

Query: 626 ------NSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIG 787
                  +LP +   LT L  L +  N  E LPP+IG    L +LSLRDN L  LP E+ 
Sbjct: 296 LTENLLMALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVLPPELA 355

Query: 788 ELTQLKELHIQGNRLTVLPPELGNLDLTGQKQIFKAEN 901
             T+L  L + GNRL  LP  L +L+L   K ++ AEN
Sbjct: 356 HTTELHVLDVAGNRLQSLPFALTHLNL---KALWLAEN 390



 Score =  102 bits (255), Expect = 5e-22
 Identities = 68/180 (37%), Positives = 96/180 (53%), Gaps = 7/180 (3%)
 Frame = +2

Query: 344 MLDVNGL-------FTLAHITQLVLSHNKLTTVPPNIAELKNLEVLNFFNNQIEELPTQI 502
           +LD N L       F L ++ +L LS N++  +PP +A    L  L+   N I E+P  I
Sbjct: 42  LLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPEIPESI 101

Query: 503 SSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLS 682
              + L+  +   N L+ LP GF  L +L  L L  N++S  +LPG+   L  L  L L 
Sbjct: 102 KFCKALEIADFSGNPLSRLPDGFTQLRSLAHLAL--NDVSLQALPGDVGNLANLVTLELR 159

Query: 683 DNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNL 862
           +N  + LP  +  L KL+ L L  NDL  LP  +G L  L+EL +  N+L+ LPPELGNL
Sbjct: 160 ENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNL 219



 Score = 99.0 bits (245), Expect = 8e-21
 Identities = 63/163 (38%), Positives = 85/163 (52%)
 Frame = +2

Query: 380 ITQLVLSHNKLTTVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTL 559
           + +L +S N +  +P +I   K LE+ +F  N +  LP   + L+ L HL L    L  L
Sbjct: 84  LVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQAL 143

Query: 560 PRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQI 739
           P   G+L  L  L+L  N L   SLP +  +L  L  L L  ND E+LP  +G L  L+ 
Sbjct: 144 PGDVGNLANLVTLELRENLLK--SLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRE 201

Query: 740 LSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNLDL 868
           L L  N L +LP E+G L +L  L +  NRL  LP ELG L L
Sbjct: 202 LWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVL 244



 Score = 97.1 bits (240), Expect = 3e-20
 Identities = 58/161 (36%), Positives = 87/161 (54%)
 Frame = +2

Query: 380 ITQLVLSHNKLTTVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTL 559
           + +L+L  N+L  +P     L NL  L   +N+I+ LP ++++  +L  L++  N +  +
Sbjct: 38  LEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPEI 97

Query: 560 PRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQI 739
           P       ALE+ D + N LS   LP  F  L +L  L L+D   + LP D+G L  L  
Sbjct: 98  PESIKFCKALEIADFSGNPLSR--LPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVT 155

Query: 740 LSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNL 862
           L LR+N L SLP  +  L +L++L + GN L VLP  LG L
Sbjct: 156 LELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGAL 196


  Database: RefSeq49_HP.fasta
    Posted date:  Oct 17, 2011  1:42 PM
  Number of letters in database: 18,297,164
  Number of sequences in database:  32,964
  
Lambda     K      H
   0.318    0.134    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 32964
Number of Hits to DB: 50,248,014
Number of extensions: 1467140
Number of successful extensions: 6171
Number of sequences better than 1.0e-05: 144
Number of HSP's gapped: 5497
Number of HSP's successfully gapped: 313
Length of query: 402
Length of database: 18,297,164
Length adjustment: 105
Effective length of query: 297
Effective length of database: 14,835,944
Effective search space: 4406275368
Effective search space used: 4406275368
Neighboring words threshold: 12
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 35 (18.1 bits)

BLASTX 2.2.24 [Aug-08-2010]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= 20110601C-000824
         (1206 letters)

Database: RefSeq49_MP.fasta 
           30,036 sequences; 15,617,559 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

Alignment   gi|NP_033131.2| ras suppressor protein 1 [Mus musculus].             529   e-150
Alignment   gi|NP_001139520.1| leucine-rich repeat-containing protein 1 iso...   113   3e-25
Alignment   gi|NP_766116.3| leucine-rich repeat-containing protein 1 isofor...   113   3e-25
Alignment   gi|NP_001116240.1| leucine-rich repeat-containing protein 8D [M...   112   4e-25
Alignment   gi|NP_848816.3| leucine-rich repeat-containing protein 8D [Mus ...   112   4e-25
Alignment   gi|NP_001074748.1| malignant fibrous histiocytoma-amplified seq...   110   3e-24
Alignment   gi|NP_598850.1| protein scribble homolog [Mus musculus].             110   3e-24
Alignment   gi|NP_808393.1| leucine-rich repeat-containing protein 8A [Mus ...   108   8e-24
Alignment   gi|NP_077156.2| leucine-rich repeat-containing protein 40 [Mus ...   107   1e-23
Alignment   gi|NP_001074642.1| leucine-rich repeat and calponin homology do...   105   7e-23

>ref|NP_033131.2| ras suppressor protein 1 [Mus musculus].
          Length = 277

 Score =  529 bits (1363), Expect = e-150
 Identities = 264/274 (96%), Positives = 271/274 (98%)
 Frame = +2

Query: 257  MSKSLKKLVEESREKNQPEVDMSDRGISNMLDVNGLFTLAHITQLVLSHNKLTTVPPNIA 436
            MSKSLKKLVEESREKNQPEVDMSDRGIS+MLDVNGLF+LAHITQLVLSHNKLTTVPPN+A
Sbjct: 1    MSKSLKKLVEESREKNQPEVDMSDRGISSMLDVNGLFSLAHITQLVLSHNKLTTVPPNVA 60

Query: 437  ELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNN 616
            ELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNN
Sbjct: 61   ELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNN 120

Query: 617  LSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELT 796
            L+E+SLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELT
Sbjct: 121  LNEHSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELT 180

Query: 797  QLKELHIQGNRLTVLPPELGNLDLTGQKQIFKAENNPWVTPIADQFQLGVSHVFEYIRSE 976
            QLKELHIQGNRLTVLPPELGNLDLTGQKQ+FKAENNPWVTPIADQFQLGVSHVFEYIRSE
Sbjct: 181  QLKELHIQGNRLTVLPPELGNLDLTGQKQVFKAENNPWVTPIADQFQLGVSHVFEYIRSE 240

Query: 977  TYKYLYGRHMQANPEPPE*NNDTSKKISRKPLTA 1078
            TYKYLYGRHMQANPEPP+ NND SKKISRKPL A
Sbjct: 241  TYKYLYGRHMQANPEPPKKNNDKSKKISRKPLAA 274


>ref|NP_001139520.1| leucine-rich repeat-containing protein 1 isoform 1 [Mus musculus].
          Length = 524

 Score =  113 bits (282), Expect = 3e-25
 Identities = 75/196 (38%), Positives = 102/196 (52%), Gaps = 6/196 (3%)
 Frame = +2

Query: 311 EVDMSDRGISNMLDVNGLFTLAHITQLVLSHNKLTTVPPNIAELKNLEVLNFFNNQIEEL 490
           E+D+ +  I N+ +  G   L H+  L L  N+L+ +P  I  LKNL  L+   N++E L
Sbjct: 178 ELDLGNNEIYNLPESIG--ALLHLKDLWLDGNQLSELPQEIGNLKNLLCLDVSENRLERL 235

Query: 491 PTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRA 670
           P +IS L  L +L +  N L T+P G G L  L +L L  N L++  LP        L  
Sbjct: 236 PEEISGLTSLTYLVISQNLLETIPEGIGKLKKLSILKLDQNRLTQ--LPEAIGDCENLTE 293

Query: 671 LYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPE 850
           L L++N    LP  IGKL KL  L+   N L+SLPKEIG    L    I+ NRLT LP E
Sbjct: 294 LVLTENRLLTLPKSIGKLKKLSNLNADRNKLVSLPKEIGGCCSLTMFCIRDNRLTRLPAE 353

Query: 851 LGN------LDLTGQK 880
           +        LD+ G +
Sbjct: 354 VSQAVELHVLDVAGNR 369



 Score =  108 bits (270), Expect = 8e-24
 Identities = 68/164 (41%), Positives = 91/164 (55%)
 Frame = +2

Query: 371 LAHITQLVLSHNKLTTVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRL 550
           L ++  L L  N LT +P ++ +L+ LE L+  NN+I  LP  I +L  LK L L  N+L
Sbjct: 150 LYNLASLELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLPESIGALLHLKDLWLDGNQL 209

Query: 551 NTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTK 730
           + LP+  G+L  L  LD++ N L    LP     LT+L  L +S N  E +P  IGKL K
Sbjct: 210 SELPQEIGNLKNLLCLDVSENRLER--LPEEISGLTSLTYLVISQNLLETIPEGIGKLKK 267

Query: 731 LQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNL 862
           L IL L  N L  LP+ IG+   L EL +  NRL  LP  +G L
Sbjct: 268 LSILKLDQNRLTQLPEAIGDCENLTELVLTENRLLTLPKSIGKL 311



 Score =  101 bits (252), Expect = 1e-21
 Identities = 65/180 (36%), Positives = 96/180 (53%), Gaps = 7/180 (3%)
 Frame = +2

Query: 344 MLDVNGL-------FTLAHITQLVLSHNKLTTVPPNIAELKNLEVLNFFNNQIEELPTQI 502
           +LD N L       F L  + +L LS N++  +PP IA    L  L+   N I E+P  I
Sbjct: 42  LLDANQLRELPEQFFQLVKLRKLGLSDNEIQRLPPEIANFMQLVELDVSRNDIPEIPESI 101

Query: 503 SSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLS 682
           +  + L+  +   N L  LP  F  L  L  L +  N++S  SLP N   L  L +L L 
Sbjct: 102 AFCKALQVADFSGNPLTRLPESFPELQNLTCLSV--NDISLQSLPENIGNLYNLASLELR 159

Query: 683 DNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNL 862
           +N    LP  + +L +L+ L L +N++ +LP+ IG L  LK+L + GN+L+ LP E+GNL
Sbjct: 160 ENLLTYLPDSLTQLRRLEELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQEIGNL 219



 Score = 62.0 bits (149), Expect = 9e-10
 Identities = 55/175 (31%), Positives = 88/175 (50%), Gaps = 7/175 (4%)
 Frame = +2

Query: 242 LPFTVMSKSLKKLVEES--REKNQPEVDMSDRGISNMLDVNGLFTLAHITQLVLSHNKLT 415
           L + V+S++L + + E   + K    + +    ++ + +  G     ++T+LVL+ N+L 
Sbjct: 245 LTYLVISQNLLETIPEGIGKLKKLSILKLDQNRLTQLPEAIG--DCENLTELVLTENRLL 302

Query: 416 TVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEV 595
           T+P +I +LK L  LN   N++  LP +I     L    +  NRL  LP        L V
Sbjct: 303 TLPKSIGKLKKLSNLNADRNKLVSLPKEIGGCCSLTMFCIRDNRLTRLPAEVSQAVELHV 362

Query: 596 LDLTYNNLSENSLPGNFFYLTT--LRALYLSDNDFEIL---PPDIGKLTKLQILS 745
           LD+  N L  + LP     LTT  L+AL+LSDN  + L     DI + T  +IL+
Sbjct: 363 LDVAGNRL--HHLP---LSLTTLKLKALWLSDNQSQPLLTFQTDIDRATGEKILT 412


>ref|NP_766116.3| leucine-rich repeat-containing protein 1 isoform 2 [Mus musculus].
          Length = 479

 Score =  113 bits (282), Expect = 3e-25
 Identities = 75/196 (38%), Positives = 102/196 (52%), Gaps = 6/196 (3%)
 Frame = +2

Query: 311 EVDMSDRGISNMLDVNGLFTLAHITQLVLSHNKLTTVPPNIAELKNLEVLNFFNNQIEEL 490
           E+D+ +  I N+ +  G   L H+  L L  N+L+ +P  I  LKNL  L+   N++E L
Sbjct: 133 ELDLGNNEIYNLPESIG--ALLHLKDLWLDGNQLSELPQEIGNLKNLLCLDVSENRLERL 190

Query: 491 PTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRA 670
           P +IS L  L +L +  N L T+P G G L  L +L L  N L++  LP        L  
Sbjct: 191 PEEISGLTSLTYLVISQNLLETIPEGIGKLKKLSILKLDQNRLTQ--LPEAIGDCENLTE 248

Query: 671 LYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPE 850
           L L++N    LP  IGKL KL  L+   N L+SLPKEIG    L    I+ NRLT LP E
Sbjct: 249 LVLTENRLLTLPKSIGKLKKLSNLNADRNKLVSLPKEIGGCCSLTMFCIRDNRLTRLPAE 308

Query: 851 LGN------LDLTGQK 880
           +        LD+ G +
Sbjct: 309 VSQAVELHVLDVAGNR 324



 Score =  108 bits (270), Expect = 8e-24
 Identities = 68/164 (41%), Positives = 91/164 (55%)
 Frame = +2

Query: 371 LAHITQLVLSHNKLTTVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRL 550
           L ++  L L  N LT +P ++ +L+ LE L+  NN+I  LP  I +L  LK L L  N+L
Sbjct: 105 LYNLASLELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLPESIGALLHLKDLWLDGNQL 164

Query: 551 NTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTK 730
           + LP+  G+L  L  LD++ N L    LP     LT+L  L +S N  E +P  IGKL K
Sbjct: 165 SELPQEIGNLKNLLCLDVSENRLER--LPEEISGLTSLTYLVISQNLLETIPEGIGKLKK 222

Query: 731 LQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNL 862
           L IL L  N L  LP+ IG+   L EL +  NRL  LP  +G L
Sbjct: 223 LSILKLDQNRLTQLPEAIGDCENLTELVLTENRLLTLPKSIGKL 266



 Score =  100 bits (250), Expect = 2e-21
 Identities = 61/166 (36%), Positives = 91/166 (54%)
 Frame = +2

Query: 365 FTLAHITQLVLSHNKLTTVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMN 544
           F L  + +L LS N++  +PP IA    L  L+   N I E+P  I+  + L+  +   N
Sbjct: 11  FQLVKLRKLGLSDNEIQRLPPEIANFMQLVELDVSRNDIPEIPESIAFCKALQVADFSGN 70

Query: 545 RLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKL 724
            L  LP  F  L  L  L +  N++S  SLP N   L  L +L L +N    LP  + +L
Sbjct: 71  PLTRLPESFPELQNLTCLSV--NDISLQSLPENIGNLYNLASLELRENLLTYLPDSLTQL 128

Query: 725 TKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNL 862
            +L+ L L +N++ +LP+ IG L  LK+L + GN+L+ LP E+GNL
Sbjct: 129 RRLEELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQEIGNL 174



 Score = 62.0 bits (149), Expect = 9e-10
 Identities = 55/175 (31%), Positives = 88/175 (50%), Gaps = 7/175 (4%)
 Frame = +2

Query: 242 LPFTVMSKSLKKLVEES--REKNQPEVDMSDRGISNMLDVNGLFTLAHITQLVLSHNKLT 415
           L + V+S++L + + E   + K    + +    ++ + +  G     ++T+LVL+ N+L 
Sbjct: 200 LTYLVISQNLLETIPEGIGKLKKLSILKLDQNRLTQLPEAIG--DCENLTELVLTENRLL 257

Query: 416 TVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEV 595
           T+P +I +LK L  LN   N++  LP +I     L    +  NRL  LP        L V
Sbjct: 258 TLPKSIGKLKKLSNLNADRNKLVSLPKEIGGCCSLTMFCIRDNRLTRLPAEVSQAVELHV 317

Query: 596 LDLTYNNLSENSLPGNFFYLTT--LRALYLSDNDFEIL---PPDIGKLTKLQILS 745
           LD+  N L  + LP     LTT  L+AL+LSDN  + L     DI + T  +IL+
Sbjct: 318 LDVAGNRL--HHLP---LSLTTLKLKALWLSDNQSQPLLTFQTDIDRATGEKILT 367



 Score = 53.1 bits (126), Expect = 4e-07
 Identities = 32/76 (42%), Positives = 41/76 (53%), Gaps = 3/76 (3%)
 Frame = +2

Query: 644 FFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQG 823
           FF L  LR L LSDN+ + LPP+I    +L  L +  ND+  +P+ I     L+     G
Sbjct: 10  FFQLVKLRKLGLSDNEIQRLPPEIANFMQLVELDVSRNDIPEIPESIAFCKALQVADFSG 69

Query: 824 NRLTVLP---PELGNL 862
           N LT LP   PEL NL
Sbjct: 70  NPLTRLPESFPELQNL 85


>ref|NP_001116240.1| leucine-rich repeat-containing protein 8D [Mus musculus].
          Length = 859

 Score =  112 bits (281), Expect = 4e-25
 Identities = 67/185 (36%), Positives = 102/185 (55%)
 Frame = +2

Query: 302  NQPEVDMSDRGISNMLDVNGLFTLAHITQLVLSHNKLTTVPPNIAELKNLEVLNFFNNQI 481
            N  E+D+    I  + ++     L  +T L L HNK+  +PP+I  +KNLE L F NN++
Sbjct: 660  NLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVAIPPSITHVKNLESLYFSNNKL 719

Query: 482  EELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTT 661
            E LPT + SLQKL+                        LD++YNN+S  ++P     L  
Sbjct: 720  ESLPTAVFSLQKLR-----------------------CLDVSYNNIS--TIPIEIGLLQN 754

Query: 662  LRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVL 841
            L+ L+++ N  +ILP  + K  KL+ L+L  N + SLP++I +LTQL +L ++GN L  L
Sbjct: 755  LQHLHITGNKVDILPKQLFKCVKLRTLNLGQNCIASLPEKISQLTQLTQLELKGNCLDRL 814

Query: 842  PPELG 856
            P +LG
Sbjct: 815  PAQLG 819



 Score = 71.6 bits (174), Expect = 1e-12
 Identities = 59/199 (29%), Positives = 96/199 (48%), Gaps = 27/199 (13%)
 Frame = +2

Query: 338  SNMLDVNGLFTLAHITQLVLSHNKLTTVPPNIAELK-NLEVLNFFNNQIEELPTQISSLQ 514
            + M+ +  L  L H+  L +  N LT VP NI ++  +L  L   N+  + L   ++SL+
Sbjct: 577  NKMIGLESLRELRHLKILHVKSN-LTKVPSNITDVAPHLTKLVIHNDGTKLLV--LNSLK 633

Query: 515  KLKH---LNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSE-------------------- 625
            K+ +   L L    L  +P    SL  L+ LDL  NN+                      
Sbjct: 634  KMMNVAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWH 693

Query: 626  ---NSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELT 796
                ++P +  ++  L +LY S+N  E LP  +  L KL+ L +  N++ ++P EIG L 
Sbjct: 694  NKIVAIPPSITHVKNLESLYFSNNKLESLPTAVFSLQKLRCLDVSYNNISTIPIEIGLLQ 753

Query: 797  QLKELHIQGNRLTVLPPEL 853
             L+ LHI GN++ +LP +L
Sbjct: 754  NLQHLHITGNKVDILPKQL 772


>ref|NP_848816.3| leucine-rich repeat-containing protein 8D [Mus musculus].
          Length = 859

 Score =  112 bits (281), Expect = 4e-25
 Identities = 67/185 (36%), Positives = 102/185 (55%)
 Frame = +2

Query: 302  NQPEVDMSDRGISNMLDVNGLFTLAHITQLVLSHNKLTTVPPNIAELKNLEVLNFFNNQI 481
            N  E+D+    I  + ++     L  +T L L HNK+  +PP+I  +KNLE L F NN++
Sbjct: 660  NLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVAIPPSITHVKNLESLYFSNNKL 719

Query: 482  EELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTT 661
            E LPT + SLQKL+                        LD++YNN+S  ++P     L  
Sbjct: 720  ESLPTAVFSLQKLR-----------------------CLDVSYNNIS--TIPIEIGLLQN 754

Query: 662  LRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVL 841
            L+ L+++ N  +ILP  + K  KL+ L+L  N + SLP++I +LTQL +L ++GN L  L
Sbjct: 755  LQHLHITGNKVDILPKQLFKCVKLRTLNLGQNCIASLPEKISQLTQLTQLELKGNCLDRL 814

Query: 842  PPELG 856
            P +LG
Sbjct: 815  PAQLG 819



 Score = 71.6 bits (174), Expect = 1e-12
 Identities = 59/199 (29%), Positives = 96/199 (48%), Gaps = 27/199 (13%)
 Frame = +2

Query: 338  SNMLDVNGLFTLAHITQLVLSHNKLTTVPPNIAELK-NLEVLNFFNNQIEELPTQISSLQ 514
            + M+ +  L  L H+  L +  N LT VP NI ++  +L  L   N+  + L   ++SL+
Sbjct: 577  NKMIGLESLRELRHLKILHVKSN-LTKVPSNITDVAPHLTKLVIHNDGTKLLV--LNSLK 633

Query: 515  KLKH---LNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSE-------------------- 625
            K+ +   L L    L  +P    SL  L+ LDL  NN+                      
Sbjct: 634  KMMNVAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWH 693

Query: 626  ---NSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELT 796
                ++P +  ++  L +LY S+N  E LP  +  L KL+ L +  N++ ++P EIG L 
Sbjct: 694  NKIVAIPPSITHVKNLESLYFSNNKLESLPTAVFSLQKLRCLDVSYNNISTIPIEIGLLQ 753

Query: 797  QLKELHIQGNRLTVLPPEL 853
             L+ LHI GN++ +LP +L
Sbjct: 754  NLQHLHITGNKVDILPKQL 772


>ref|NP_001074748.1| malignant fibrous histiocytoma-amplified sequence 1 homolog [Mus
           musculus].
          Length = 1048

 Score =  110 bits (274), Expect = 3e-24
 Identities = 82/239 (34%), Positives = 117/239 (48%), Gaps = 21/239 (8%)
 Frame = +2

Query: 311 EVDMSDRGISNMLDVNGLFTLAHITQLVLSHNKLTTVPPNIAELKNLEVLNFFNNQIEEL 490
           E+D+S   ++++ D      L H+  L + HN+LT  P  + +L  LE L+  +N++  L
Sbjct: 158 ELDVSFNRLAHLPD--SFSCLNHLRTLDVDHNQLTAFPQQLLQLAALEELDVSSNRLRGL 215

Query: 491 PTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYN------------------N 616
           P  IS+L+ LK L L    L TLPRGF  L +LE L L  N                  N
Sbjct: 216 PEDISALRALKILWLSGAELGTLPRGFCELASLESLMLDNNGLQALPDEFSRLQRLKMLN 275

Query: 617 LSEN---SLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIG 787
           LS N     P     L  L  LYLS N    +P  I  L +L  L L +N +  LP  I 
Sbjct: 276 LSSNLFEEFPAALLPLAGLEELYLSRNQLTSVPSLIAGLGRLLTLWLDNNRIRYLPDSIV 335

Query: 788 ELTQLKELHIQGNRLTVLPPELGNLDLTGQKQIFKAENNPWVTPIADQFQLGVSHVFEY 964
           ELT L+EL +QGN++ VLP   G L   G   ++K ++NP + P  +    G+ ++  Y
Sbjct: 336 ELTGLEELVLQGNQIAVLPDNFGQLSRVG---LWKIKDNPLIQPPYEVCMKGIPYIAAY 391



 Score = 96.7 bits (239), Expect = 3e-20
 Identities = 60/163 (36%), Positives = 85/163 (52%), Gaps = 1/163 (0%)
 Frame = +2

Query: 377 HITQLVLSHNKLTTVPPNIAE-LKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLN 553
           H+T+L +SHN+LT +   +   L+ L  LN  +NQ+  LP Q+ +L  L+ L++  NRL 
Sbjct: 108 HLTELDVSHNRLTILGAEVVSALRELRKLNLSHNQLPALPAQLGALAHLEELDVSFNRLA 167

Query: 554 TLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKL 733
            LP  F  L  L  LD+ +N L+  + P     L  L  L +S N    LP DI  L  L
Sbjct: 168 HLPDSFSCLNHLRTLDVDHNQLT--AFPQQLLQLAALEELDVSSNRLRGLPEDISALRAL 225

Query: 734 QILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNL 862
           +IL L   +L +LP+   EL  L+ L +  N L  LP E   L
Sbjct: 226 KILWLSGAELGTLPRGFCELASLESLMLDNNGLQALPDEFSRL 268



 Score = 52.8 bits (125), Expect = 5e-07
 Identities = 47/129 (36%), Positives = 64/129 (49%), Gaps = 3/129 (2%)
 Frame = +2

Query: 488 LPTQISSLQKLKHLNLGMNRLNTLPRGFGS-LPALEVLDLTYNNLSENSLPGNFFYLTT- 661
           LP  I  ++ L   NLG N L  +P G GS L +L VL L  N  +   LP     L   
Sbjct: 54  LPANIGDIEVL---NLGNNGLEDVPEGLGSALGSLRVLVLRRNRFAR--LPPAVAELGHH 108

Query: 662 LRALYLSDNDFEILPPDI-GKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTV 838
           L  L +S N   IL  ++   L +L+ L+L  N L +LP ++G L  L+EL +  NRL  
Sbjct: 109 LTELDVSHNRLTILGAEVVSALRELRKLNLSHNQLPALPAQLGALAHLEELDVSFNRLAH 168

Query: 839 LPPELGNLD 865
           LP     L+
Sbjct: 169 LPDSFSCLN 177


>ref|NP_598850.1| protein scribble homolog [Mus musculus].
          Length = 1665

 Score =  110 bits (274), Expect = 3e-24
 Identities = 73/218 (33%), Positives = 106/218 (48%), Gaps = 21/218 (9%)
 Frame = +2

Query: 311 EVDMSDRGISNMLDVNGLFTLAHITQLVLSHNKLTTVPPNIAELKNLEVLNFFNNQIEEL 490
           ++D+    +  + D  G   L ++ +L L  N+L+ +PP +  L+ L  L+   N++EEL
Sbjct: 178 QLDLGGNDLEVLPDTLG--ALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEEL 235

Query: 491 PTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSE--------------- 625
           P ++  L  L  L L  N L  LP G G L  L +L +  N L E               
Sbjct: 236 PVELGGLALLTDLLLSQNLLQRLPEGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELI 295

Query: 626 ------NSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIG 787
                  +LP +   LT L  L +  N  E+LPP+IG    L +LSLRDN L  LP E+ 
Sbjct: 296 LTENLLTALPHSLGKLTKLTNLNVDRNHLEVLPPEIGGCVALSVLSLRDNRLAVLPPELA 355

Query: 788 ELTQLKELHIQGNRLTVLPPELGNLDLTGQKQIFKAEN 901
              +L  L + GNRL  LP  L +L+L   K ++ AEN
Sbjct: 356 HTAELHVLDVAGNRLRSLPFALTHLNL---KALWLAEN 390



 Score =  102 bits (255), Expect = 5e-22
 Identities = 68/180 (37%), Positives = 96/180 (53%), Gaps = 7/180 (3%)
 Frame = +2

Query: 344 MLDVNGL-------FTLAHITQLVLSHNKLTTVPPNIAELKNLEVLNFFNNQIEELPTQI 502
           +LD N L       F L ++ +L LS N++  +PP +A    L  L+   N I E+P  I
Sbjct: 42  LLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPEIPESI 101

Query: 503 SSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLS 682
              + L+  +   N L+ LP GF  L +L  L L  N++S  +LPG+   L  L  L L 
Sbjct: 102 KFCKALEIADFSGNPLSRLPDGFTQLRSLAHLAL--NDVSLQALPGDVGNLANLVTLELR 159

Query: 683 DNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNL 862
           +N  + LP  +  L KL+ L L  NDL  LP  +G L  L+EL +  N+L+ LPPELGNL
Sbjct: 160 ENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNL 219



 Score = 99.0 bits (245), Expect = 7e-21
 Identities = 63/163 (38%), Positives = 85/163 (52%)
 Frame = +2

Query: 380 ITQLVLSHNKLTTVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTL 559
           + +L +S N +  +P +I   K LE+ +F  N +  LP   + L+ L HL L    L  L
Sbjct: 84  LVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQAL 143

Query: 560 PRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQI 739
           P   G+L  L  L+L  N L   SLP +  +L  L  L L  ND E+LP  +G L  L+ 
Sbjct: 144 PGDVGNLANLVTLELRENLLK--SLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRE 201

Query: 740 LSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNLDL 868
           L L  N L +LP E+G L +L  L +  NRL  LP ELG L L
Sbjct: 202 LWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPVELGGLAL 244



 Score = 97.1 bits (240), Expect = 3e-20
 Identities = 58/161 (36%), Positives = 87/161 (54%)
 Frame = +2

Query: 380 ITQLVLSHNKLTTVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTL 559
           + +L+L  N+L  +P     L NL  L   +N+I+ LP ++++  +L  L++  N +  +
Sbjct: 38  LEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPEI 97

Query: 560 PRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQI 739
           P       ALE+ D + N LS   LP  F  L +L  L L+D   + LP D+G L  L  
Sbjct: 98  PESIKFCKALEIADFSGNPLSR--LPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVT 155

Query: 740 LSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNL 862
           L LR+N L SLP  +  L +L++L + GN L VLP  LG L
Sbjct: 156 LELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGAL 196


>ref|NP_808393.1| leucine-rich repeat-containing protein 8A [Mus musculus].
          Length = 810

 Score =  108 bits (270), Expect = 8e-24
 Identities = 67/186 (36%), Positives = 101/186 (54%), Gaps = 2/186 (1%)
 Frame = +2

Query: 302  NQPEVDMSDRGISNMLDVNGLFTLAHITQLVLSHNKLTTVPPNIAELKNLEVLNFFNNQI 481
            N  E+D+ D  +  + ++     L  +T L L +N +  +P  I  L NLE L    N+I
Sbjct: 615  NLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKI 674

Query: 482  EELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTT 661
            E++PTQ+   +KL++L+L  N L  LP   G L  L+ L +T N +   +LP   F    
Sbjct: 675  EKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAVTANRI--EALPPELFQCRK 732

Query: 662  LRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKE--LHIQGNRLT 835
            LRAL+L +N  + LP  +G+LT L  + LR N L  LP E+GE   LK   L ++ +  +
Sbjct: 733  LRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPLLKRSGLVVEEDLFS 792

Query: 836  VLPPEL 853
             LPPE+
Sbjct: 793  TLPPEV 798


>ref|NP_077156.2| leucine-rich repeat-containing protein 40 [Mus musculus].
          Length = 602

 Score =  107 bits (268), Expect = 1e-23
 Identities = 75/207 (36%), Positives = 112/207 (54%), Gaps = 1/207 (0%)
 Frame = +2

Query: 359 GLFTLAHITQLVLSHNKLTTVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLG 538
           G   L+ +  L LS N+L TVP + A L +L  LN  +NQ++ LP +IS +++LKHL+  
Sbjct: 169 GFEHLSCLEDLDLSSNRLATVPADFALLSSLLRLNLSSNQLKNLPAEISRMKRLKHLDCD 228

Query: 539 MNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPD-I 715
            N L T+P   GS+ +LE+L L  N L    LP  F     L+ L+L++N  E L  + +
Sbjct: 229 ANLLETVPPDVGSMESLELLYLRRNKL--RVLP-EFPSCRQLKELHLAENQIEKLGAEHL 285

Query: 716 GKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNLDLTGQKQIFKA 895
             L  + +L LR N L S+P+E+  L  L+ L +  N ++ LP  LGNL L    +    
Sbjct: 286 QHLQAILVLDLRGNKLRSVPEEMALLQSLERLDLSNNDISSLPCSLGNLHL----KFLAL 341

Query: 896 ENNPWVTPIADQFQLGVSHVFEYIRSE 976
           E NP  T   +    G   V +Y+RS+
Sbjct: 342 EGNPLRTIRREIIAKGTQEVLKYLRSK 368



 Score =  105 bits (262), Expect = 7e-23
 Identities = 73/219 (33%), Positives = 124/219 (56%), Gaps = 2/219 (0%)
 Frame = +2

Query: 371  LAHITQLVLSHNKLTTVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRL 550
            L  +T L +  N+LT++P  I EL NL+ LN  +N+++ LP +I+SL+ L+ L+L  N L
Sbjct: 104  LPALTVLDIHDNQLTSLPSAIRELDNLQKLNVSHNKLKILPEEITSLKNLRTLHLQHNEL 163

Query: 551  NTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTK 730
              +P GF  L  LE LDL+ N L+  ++P +F  L++L  L LS N  + LP +I ++ +
Sbjct: 164  TCIPEGFEHLSCLEDLDLSSNRLA--TVPADFALLSSLLRLNLSSNQLKNLPAEISRMKR 221

Query: 731  LQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLP--PELGNLDLTGQKQIFKAENN 904
            L+ L    N L ++P ++G +  L+ L+++ N+L VLP  P    L     K++  AEN 
Sbjct: 222  LKHLDCDANLLETVPPDVGSMESLELLYLRRNKLRVLPEFPSCRQL-----KELHLAEN- 275

Query: 905  PWVTPIADQFQLGVSHVFEYIRSETYKYLYGRHMQANPE 1021
                      +LG  H+ +++++     L G  +++ PE
Sbjct: 276  -------QIEKLGAEHL-QHLQAILVLDLRGNKLRSVPE 306



 Score =  100 bits (249), Expect = 2e-21
 Identities = 58/162 (35%), Positives = 90/162 (55%)
 Frame = +2

Query: 380 ITQLVLSHNKLTTVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTL 559
           +T+L++S NKL ++  ++  L  L VL+  +NQ+  LP+ I  L  L+ LN+  N+L  L
Sbjct: 84  LTKLIISSNKLQSLSDDLRLLPALTVLDIHDNQLTSLPSAIRELDNLQKLNVSHNKLKIL 143

Query: 560 PRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQI 739
           P    SL  L  L L +N L+   +P  F +L+ L  L LS N    +P D   L+ L  
Sbjct: 144 PEEITSLKNLRTLHLQHNELT--CIPEGFEHLSCLEDLDLSSNRLATVPADFALLSSLLR 201

Query: 740 LSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNLD 865
           L+L  N L +LP EI  + +LK L    N L  +PP++G+++
Sbjct: 202 LNLSSNQLKNLPAEISRMKRLKHLDCDANLLETVPPDVGSME 243



 Score = 84.7 bits (208), Expect = 1e-16
 Identities = 67/241 (27%), Positives = 119/241 (49%), Gaps = 5/241 (2%)
 Frame = +2

Query: 263  KSLKKLVEESREKNQPEVDMSDRGISNMLDVNGLFTLAHITQLVLSHNKLTTVPPNIAEL 442
            K L+  +++ R      V  +   + +   VN +  +A +  L  S  + T +P ++ + 
Sbjct: 363  KYLRSKIKDDRTNQNDSVPETAMTLPSEARVN-IHAIATLKLLDYSDKQATLIPDDLFDA 421

Query: 443  KNLEVL---NFFNNQIEELPTQISSLQKLK-HLNLGMNRLNTLPRGFGSLPALEVLDLTY 610
                ++   NF  NQ+ E+P +I  L+++   +NL  N+L+ +      L  L  LDL  
Sbjct: 422  TKTTLITSINFSKNQLCEIPQRIVELKEMVLDINLSFNKLSFISHELCLLQKLTFLDLRN 481

Query: 611  NNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISL-PKEIG 787
            N LS  SLP     LT L+ + LS N F++ P  + +++ L+ + + +N + S+ P+++ 
Sbjct: 482  NFLS--SLPEEMSSLTKLQTINLSFNRFKVFPEVLYRISTLEAVLISNNQVGSVDPQKMK 539

Query: 788  ELTQLKELHIQGNRLTVLPPELGNLDLTGQKQIFKAENNPWVTPIADQFQLGVSHVFEYI 967
             +  L  L +Q N L  +PPELGN     Q +    + NP+  P A     G + V EY+
Sbjct: 540  LMENLNTLDLQNNDLLQIPPELGN---CVQLRTLLLDGNPFRVPRAAILMKGTAAVLEYL 596

Query: 968  R 970
            R
Sbjct: 597  R 597



 Score = 57.8 bits (138), Expect = 2e-08
 Identities = 62/241 (25%), Positives = 94/241 (39%), Gaps = 70/241 (29%)
 Frame = +2

Query: 341 NMLDVNGLFTLAHITQLV---LSHNKLTTVPPNIAELKNLEVLNFFNNQIEELPTQISSL 511
           N ++  G   L H+  ++   L  NKL +VP  +A L++LE L+  NN I  LP  + +L
Sbjct: 275 NQIEKLGAEHLQHLQAILVLDLRGNKLRSVPEEMALLQSLERLDLSNNDISSLPCSLGNL 334

Query: 512 QKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSEN-------------SLPG---- 640
             LK L L  N L T+ R   +    EVL    + + ++             +LP     
Sbjct: 335 H-LKFLALEGNPLRTIRREIIAKGTQEVLKYLRSKIKDDRTNQNDSVPETAMTLPSEARV 393

Query: 641 NFFYLTTLRALYLSDNDFEILPPDIGKLTK------------------------------ 730
           N   + TL+ L  SD    ++P D+   TK                              
Sbjct: 394 NIHAIATLKLLDYSDKQATLIPDDLFDATKTTLITSINFSKNQLCEIPQRIVELKEMVLD 453

Query: 731 --------------------LQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPE 850
                               L  L LR+N L SLP+E+  LT+L+ +++  NR  V P  
Sbjct: 454 INLSFNKLSFISHELCLLQKLTFLDLRNNFLSSLPEEMSSLTKLQTINLSFNRFKVFPEV 513

Query: 851 L 853
           L
Sbjct: 514 L 514



 Score = 55.5 bits (132), Expect = 8e-08
 Identities = 36/112 (32%), Positives = 58/112 (51%), Gaps = 6/112 (5%)
 Frame = +2

Query: 545 RLNTLPRGFGSLPA------LEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILP 706
           +LN   R  G +P       +++ +    NLS +S    ++  T L  L +S N  + L 
Sbjct: 40  QLNLAGRNLGEVPQCVWRINVDIPEEANQNLSFSSTE-RWWDQTDLTKLIISSNKLQSLS 98

Query: 707 PDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNL 862
            D+  L  L +L + DN L SLP  I EL  L++L++  N+L +LP E+ +L
Sbjct: 99  DDLRLLPALTVLDIHDNQLTSLPSAIRELDNLQKLNVSHNKLKILPEEITSL 150


>ref|NP_001074642.1| leucine-rich repeat and calponin homology domain-containing protein
           2 [Mus musculus].
          Length = 773

 Score =  105 bits (262), Expect = 7e-23
 Identities = 75/225 (33%), Positives = 118/225 (52%), Gaps = 9/225 (4%)
 Frame = +2

Query: 320 MSDRGISNMLDVNGL---------FTLAHITQLVLSHNKLTTVPPNIAELKNLEVLNFFN 472
           + + G S +L ++G          + L   TQ  LS N+ T +P ++     LE LN ++
Sbjct: 92  LEEAGNSGILSLSGRKLREFPGSGYDLTDTTQADLSRNRFTEIPSDVWLFAPLETLNLYH 151

Query: 473 NQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFY 652
           N I+ +P  I +LQ L +LN+  N L+TLP+    LP L+VL ++ N L   S+P     
Sbjct: 152 NCIKTIPEAIKNLQMLTYLNISRNLLSTLPKYLFDLP-LKVLVVSNNKLV--SIPEEIGK 208

Query: 653 LTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRL 832
           L  L  L +S N+ ++LP  +GKL  L+ L++R N+L  LP E+G+L  +K L    N++
Sbjct: 209 LKDLMELDVSCNEIQVLPQQMGKLHSLKELNIRRNNLHVLPDELGDLPLVK-LDFSCNKV 267

Query: 833 TVLPPELGNLDLTGQKQIFKAENNPWVTPIADQFQLGVSHVFEYI 967
           T +P     L      Q+   +NNP   P A     G  H+F+Y+
Sbjct: 268 TEIPVCYRKLH---HLQVIILDNNPLQVPPAQICLKGKVHIFKYL 309


  Database: RefSeq49_MP.fasta
    Posted date:  Oct 17, 2011  1:42 PM
  Number of letters in database: 15,617,559
  Number of sequences in database:  30,036
  
Lambda     K      H
   0.318    0.134    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 30036
Number of Hits to DB: 42,326,339
Number of extensions: 1217271
Number of successful extensions: 5207
Number of sequences better than 1.0e-05: 124
Number of HSP's gapped: 4615
Number of HSP's successfully gapped: 271
Length of query: 402
Length of database: 15,617,559
Length adjustment: 104
Effective length of query: 298
Effective length of database: 12,493,815
Effective search space: 3723156870
Effective search space used: 3723156870
Neighboring words threshold: 12
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 35 (18.1 bits)

BLASTX 2.2.24 [Aug-08-2010]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= 20110601C-000824
         (1206 letters)

Database: RefSeq49_SP.fasta 
           24,897 sequences; 11,343,932 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

Alignment   gi|XP_003361200.1| PREDICTED: ras suppressor protein 1-like [Su...   326   2e-89
Alignment   gi|XP_003357790.1| PREDICTED: ras suppressor protein 1-like [Su...   213   2e-55
Alignment   gi|XP_001929199.1| PREDICTED: leucine-rich repeat-containing pr...   114   8e-26
Alignment   gi|XP_003125962.1| PREDICTED: leucine-rich repeat-containing pr...   114   8e-26
Alignment   gi|XP_003355348.1| PREDICTED: leucine-rich repeat-containing pr...   114   8e-26
Alignment   gi|XP_001927723.2| PREDICTED: leucine-rich repeat-containing pr...   108   5e-24
Alignment   gi|XP_001928885.1| PREDICTED: leucine-rich repeat-containing pr...   108   8e-24
Alignment   gi|XP_003127976.1| PREDICTED: leucine-rich repeat-containing pr...   107   2e-23
Alignment   gi|XP_001924728.3| PREDICTED: leucine-rich repeat and calponin ...   102   3e-22
Alignment   gi|XP_001927528.1| PREDICTED: leucine-rich repeat protein SHOC-...   102   3e-22

>ref|XP_003361200.1| PREDICTED: ras suppressor protein 1-like [Sus scrofa].
          Length = 237

 Score =  326 bits (835), Expect = 2e-89
 Identities = 172/213 (80%), Positives = 182/213 (85%), Gaps = 21/213 (9%)
 Frame = +2

Query: 287 ESREKNQPEVDMSDRGISNMLDVN--------------------GL-FTLAHITQLVLSH 403
           ES+     ++++++RG+S   DV+                    GL  TLAHITQLVLSH
Sbjct: 20  ESQGNRYSDIEVTERGLSATCDVDSELDPFFLLGTLGETWMGASGLDITLAHITQLVLSH 79

Query: 404 NKLTTVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLP 583
           NKLTTVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLP
Sbjct: 80  NKLTTVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLP 139

Query: 584 ALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDL 763
           ALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDL
Sbjct: 140 ALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDL 199

Query: 764 ISLPKEIGELTQLKELHIQGNRLTVLPPELGNL 862
           ISLPKEIGELTQLKELHIQGNRLTVLPPELG +
Sbjct: 200 ISLPKEIGELTQLKELHIQGNRLTVLPPELGKV 232


>ref|XP_003357790.1| PREDICTED: ras suppressor protein 1-like [Sus scrofa].
          Length = 113

 Score =  213 bits (541), Expect = 2e-55
 Identities = 106/108 (98%), Positives = 107/108 (99%)
 Frame = +2

Query: 539 MNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIG 718
           MNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIG
Sbjct: 1   MNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIG 60

Query: 719 KLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNL 862
           KLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELG +
Sbjct: 61  KLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGKV 108



 Score = 61.6 bits (148), Expect = 8e-10
 Identities = 40/109 (36%), Positives = 55/109 (50%), Gaps = 2/109 (1%)
 Frame = +2

Query: 404 NKLTTVPPNIAELKNLEVLNFFNNQIEE--LPTQISSLQKLKHLNLGMNRLNTLPRGFGS 577
           N+L T+P     L  LEVL+   N + E  LP     L  L+ L L  N    LP   G 
Sbjct: 2   NRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGK 61

Query: 578 LPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKL 724
           L  L++L L  N+L   SLP     LT L+ L++  N   +LPP++GK+
Sbjct: 62  LTKLQILSLRDNDLI--SLPKEIGELTQLKELHIQGNRLTVLPPELGKV 108


>ref|XP_001929199.1| PREDICTED: leucine-rich repeat-containing protein 8D isoform 1 [Sus
            scrofa].
          Length = 858

 Score =  114 bits (286), Expect = 8e-26
 Identities = 69/186 (37%), Positives = 104/186 (55%), Gaps = 2/186 (1%)
 Frame = +2

Query: 302  NQPEVDMSDRGISNMLDVNGLFTLAHITQLVLSHNKLTTVPPNIAELKNLEVLNFFNNQI 481
            N  E+D+    I  + ++     L  +T L L HNK+ T+PP+I  +KNLE L F NN++
Sbjct: 659  NLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKL 718

Query: 482  EELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTT 661
            E LP  + SLQKL+ L++  N ++T+P   G L  L+ L LT N +   +LP   F    
Sbjct: 719  ESLPVAVFSLQKLRCLDVSYNSISTIPLEIGLLQNLQHLHLTGNKV--ETLPKQLFKCGK 776

Query: 662  LRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKE--LHIQGNRLT 835
            LR L L  N    LP  +G+L++L  L L+ N L  LP ++G+   LK+  L ++G+   
Sbjct: 777  LRTLNLGQNCLTSLPDQVGQLSQLTQLELKGNCLDRLPAQLGQCRLLKKGGLVVEGHLFD 836

Query: 836  VLPPEL 853
             LP E+
Sbjct: 837  TLPLEV 842



 Score = 83.2 bits (204), Expect = 3e-16
 Identities = 60/185 (32%), Positives = 97/185 (52%), Gaps = 2/185 (1%)
 Frame = +2

Query: 338  SNMLDVNGLFTLAHITQLVLSHNKLTTVPPNIAELKNLEVLNFFNNQIEELPTQIS--SL 511
            + +L +N L  + ++ +L L + +L  +P  I  L NL+ L+  +N I  +   IS   L
Sbjct: 623  TKLLVLNSLKKMMNVAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHL 682

Query: 512  QKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDND 691
            ++L  L L  N++ T+P     +  LE L  + N L   SLP   F L  LR L +S N 
Sbjct: 683  KRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLE--SLPVAVFSLQKLRCLDVSYNS 740

Query: 692  FEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNLDLT 871
               +P +IG L  LQ L L  N + +LPK++ +  +L+ L++  N LT LP ++G L   
Sbjct: 741  ISTIPLEIGLLQNLQHLHLTGNKVETLPKQLFKCGKLRTLNLGQNCLTSLPDQVGQLSQL 800

Query: 872  GQKQI 886
             Q ++
Sbjct: 801  TQLEL 805


>ref|XP_003125962.1| PREDICTED: leucine-rich repeat-containing protein 8D isoform 2 [Sus
            scrofa].
          Length = 858

 Score =  114 bits (286), Expect = 8e-26
 Identities = 69/186 (37%), Positives = 104/186 (55%), Gaps = 2/186 (1%)
 Frame = +2

Query: 302  NQPEVDMSDRGISNMLDVNGLFTLAHITQLVLSHNKLTTVPPNIAELKNLEVLNFFNNQI 481
            N  E+D+    I  + ++     L  +T L L HNK+ T+PP+I  +KNLE L F NN++
Sbjct: 659  NLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKL 718

Query: 482  EELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTT 661
            E LP  + SLQKL+ L++  N ++T+P   G L  L+ L LT N +   +LP   F    
Sbjct: 719  ESLPVAVFSLQKLRCLDVSYNSISTIPLEIGLLQNLQHLHLTGNKV--ETLPKQLFKCGK 776

Query: 662  LRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKE--LHIQGNRLT 835
            LR L L  N    LP  +G+L++L  L L+ N L  LP ++G+   LK+  L ++G+   
Sbjct: 777  LRTLNLGQNCLTSLPDQVGQLSQLTQLELKGNCLDRLPAQLGQCRLLKKGGLVVEGHLFD 836

Query: 836  VLPPEL 853
             LP E+
Sbjct: 837  TLPLEV 842



 Score = 83.2 bits (204), Expect = 3e-16
 Identities = 60/185 (32%), Positives = 97/185 (52%), Gaps = 2/185 (1%)
 Frame = +2

Query: 338  SNMLDVNGLFTLAHITQLVLSHNKLTTVPPNIAELKNLEVLNFFNNQIEELPTQIS--SL 511
            + +L +N L  + ++ +L L + +L  +P  I  L NL+ L+  +N I  +   IS   L
Sbjct: 623  TKLLVLNSLKKMMNVAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHL 682

Query: 512  QKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDND 691
            ++L  L L  N++ T+P     +  LE L  + N L   SLP   F L  LR L +S N 
Sbjct: 683  KRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLE--SLPVAVFSLQKLRCLDVSYNS 740

Query: 692  FEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNLDLT 871
               +P +IG L  LQ L L  N + +LPK++ +  +L+ L++  N LT LP ++G L   
Sbjct: 741  ISTIPLEIGLLQNLQHLHLTGNKVETLPKQLFKCGKLRTLNLGQNCLTSLPDQVGQLSQL 800

Query: 872  GQKQI 886
             Q ++
Sbjct: 801  TQLEL 805


>ref|XP_003355348.1| PREDICTED: leucine-rich repeat-containing protein 8D [Sus scrofa].
          Length = 858

 Score =  114 bits (286), Expect = 8e-26
 Identities = 69/186 (37%), Positives = 104/186 (55%), Gaps = 2/186 (1%)
 Frame = +2

Query: 302  NQPEVDMSDRGISNMLDVNGLFTLAHITQLVLSHNKLTTVPPNIAELKNLEVLNFFNNQI 481
            N  E+D+    I  + ++     L  +T L L HNK+ T+PP+I  +KNLE L F NN++
Sbjct: 659  NLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKL 718

Query: 482  EELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTT 661
            E LP  + SLQKL+ L++  N ++T+P   G L  L+ L LT N +   +LP   F    
Sbjct: 719  ESLPVAVFSLQKLRCLDVSYNSISTIPLEIGLLQNLQHLHLTGNKV--ETLPKQLFKCGK 776

Query: 662  LRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKE--LHIQGNRLT 835
            LR L L  N    LP  +G+L++L  L L+ N L  LP ++G+   LK+  L ++G+   
Sbjct: 777  LRTLNLGQNCLTSLPDQVGQLSQLTQLELKGNCLDRLPAQLGQCRLLKKGGLVVEGHLFD 836

Query: 836  VLPPEL 853
             LP E+
Sbjct: 837  TLPLEV 842



 Score = 83.2 bits (204), Expect = 3e-16
 Identities = 60/185 (32%), Positives = 97/185 (52%), Gaps = 2/185 (1%)
 Frame = +2

Query: 338  SNMLDVNGLFTLAHITQLVLSHNKLTTVPPNIAELKNLEVLNFFNNQIEELPTQIS--SL 511
            + +L +N L  + ++ +L L + +L  +P  I  L NL+ L+  +N I  +   IS   L
Sbjct: 623  TKLLVLNSLKKMMNVAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHL 682

Query: 512  QKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDND 691
            ++L  L L  N++ T+P     +  LE L  + N L   SLP   F L  LR L +S N 
Sbjct: 683  KRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLE--SLPVAVFSLQKLRCLDVSYNS 740

Query: 692  FEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNLDLT 871
               +P +IG L  LQ L L  N + +LPK++ +  +L+ L++  N LT LP ++G L   
Sbjct: 741  ISTIPLEIGLLQNLQHLHLTGNKVETLPKQLFKCGKLRTLNLGQNCLTSLPDQVGQLSQL 800

Query: 872  GQKQI 886
             Q ++
Sbjct: 801  TQLEL 805


>ref|XP_001927723.2| PREDICTED: leucine-rich repeat-containing protein 1 [Sus scrofa].
          Length = 524

 Score =  108 bits (271), Expect = 5e-24
 Identities = 68/164 (41%), Positives = 92/164 (56%)
 Frame = +2

Query: 371 LAHITQLVLSHNKLTTVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRL 550
           L ++  L L  N LT +P ++ +L+ LE L+  NN+I  LP  I +L  LK L L  N+L
Sbjct: 150 LYNLASLELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLPESIGALLHLKDLWLDGNQL 209

Query: 551 NTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTK 730
           + LP+  G+L  L  LD++ N L    LP     LT+L  L +S N  E+LP  IGKL K
Sbjct: 210 SELPQEIGNLKNLLCLDVSENRLER--LPEEISGLTSLTDLVISQNLLEMLPDGIGKLKK 267

Query: 731 LQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNL 862
           L IL +  N L  LP+ IG+   L EL +  NRL  LP  +G L
Sbjct: 268 LSILKVDQNRLTQLPEAIGDCESLTELVLTENRLLTLPKSIGKL 311



 Score =  107 bits (268), Expect = 1e-23
 Identities = 72/196 (36%), Positives = 101/196 (51%), Gaps = 6/196 (3%)
 Frame = +2

Query: 311 EVDMSDRGISNMLDVNGLFTLAHITQLVLSHNKLTTVPPNIAELKNLEVLNFFNNQIEEL 490
           E+D+ +  I N+ +  G   L H+  L L  N+L+ +P  I  LKNL  L+   N++E L
Sbjct: 178 ELDLGNNEIYNLPESIG--ALLHLKDLWLDGNQLSELPQEIGNLKNLLCLDVSENRLERL 235

Query: 491 PTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRA 670
           P +IS L  L  L +  N L  LP G G L  L +L +  N L++  LP       +L  
Sbjct: 236 PEEISGLTSLTDLVISQNLLEMLPDGIGKLKKLSILKVDQNRLTQ--LPEAIGDCESLTE 293

Query: 671 LYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPE 850
           L L++N    LP  IGKL KL  L+   N L+SLPKEIG    L    ++ NRLT +P E
Sbjct: 294 LVLTENRLLTLPKSIGKLKKLSNLNADRNKLVSLPKEIGGCCSLTVFCVRDNRLTRIPAE 353

Query: 851 LGN------LDLTGQK 880
           +        LD+ G +
Sbjct: 354 VSQATELHVLDVAGNR 369



 Score =  102 bits (255), Expect = 3e-22
 Identities = 66/180 (36%), Positives = 96/180 (53%), Gaps = 7/180 (3%)
 Frame = +2

Query: 344 MLDVNGL-------FTLAHITQLVLSHNKLTTVPPNIAELKNLEVLNFFNNQIEELPTQI 502
           +LD N L       F L  + +L LS N++  +PP IA    L  L+   N I E+P  I
Sbjct: 42  LLDANQLRELPEQFFQLVKLRKLGLSDNEIQRLPPEIANFMQLVELDVSRNDIPEIPESI 101

Query: 503 SSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLS 682
           S  + L+  +   N L  LP  F  L  L  L +  N++S  SLP N   L  L +L L 
Sbjct: 102 SFCKALQIADFSGNPLTRLPESFPELQNLTCLSV--NDISLQSLPENIGNLYNLASLELR 159

Query: 683 DNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNL 862
           +N    LP  + +L +L+ L L +N++ +LP+ IG L  LK+L + GN+L+ LP E+GNL
Sbjct: 160 ENLLTYLPDSLTQLRRLEELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQEIGNL 219



 Score = 87.4 bits (215), Expect = 1e-17
 Identities = 58/167 (34%), Positives = 86/167 (51%)
 Frame = +2

Query: 356 NGLFTLAHITQLVLSHNKLTTVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNL 535
           + L  L  + +L L +N++  +P +I  L +L+ L    NQ+ ELP +I +L+ L  L++
Sbjct: 168 DSLTQLRRLEELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQEIGNLKNLLCLDV 227

Query: 536 GMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDI 715
             NRL  LP     L +L  L ++ N L    LP     L  L  L +  N    LP  I
Sbjct: 228 SENRLERLPEEISGLTSLTDLVISQNLL--EMLPDGIGKLKKLSILKVDQNRLTQLPEAI 285

Query: 716 GKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELG 856
           G    L  L L +N L++LPK IG+L +L  L+   N+L  LP E+G
Sbjct: 286 GDCESLTELVLTENRLLTLPKSIGKLKKLSNLNADRNKLVSLPKEIG 332



 Score = 84.0 bits (206), Expect = 2e-16
 Identities = 61/191 (31%), Positives = 88/191 (46%), Gaps = 1/191 (0%)
 Frame = +2

Query: 299 KNQPEVDMSDRGISNMLD-VNGLFTLAHITQLVLSHNKLTTVPPNIAELKNLEVLNFFNN 475
           KN   +D+S+  +  + + ++GL +L   T LV+S N L  +P  I +LK L +L    N
Sbjct: 220 KNLLCLDVSENRLERLPEEISGLTSL---TDLVISQNLLEMLPDGIGKLKKLSILKVDQN 276

Query: 476 QIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYL 655
           ++ +LP  I   + L  L L  NRL TLP+  G L  L  L+   N L            
Sbjct: 277 RLTQLPEAIGDCESLTELVLTENRLLTLPKSIGKLKKLSNLNADRNKLVS---------- 326

Query: 656 TTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLT 835
                          LP +IG    L +  +RDN L  +P E+ + T+L  L + GNRL 
Sbjct: 327 ---------------LPKEIGGCCSLTVFCVRDNRLTRIPAEVSQATELHVLDVAGNRLL 371

Query: 836 VLPPELGNLDL 868
            LP  L  L L
Sbjct: 372 HLPLSLTTLKL 382


>ref|XP_001928885.1| PREDICTED: leucine-rich repeat-containing protein 8A [Sus scrofa].
          Length = 810

 Score =  108 bits (269), Expect = 8e-24
 Identities = 67/186 (36%), Positives = 100/186 (53%), Gaps = 2/186 (1%)
 Frame = +2

Query: 302  NQPEVDMSDRGISNMLDVNGLFTLAHITQLVLSHNKLTTVPPNIAELKNLEVLNFFNNQI 481
            N  E+D+ D  +  + ++     L  +T L L +N +  +P  I  L NLE L    N+I
Sbjct: 615  NLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKI 674

Query: 482  EELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTT 661
            E++PTQ+   +KL++L+L  N L  LP   G L  L+ L +T N +   +LP   F    
Sbjct: 675  EKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAVTANRI--EALPPELFQCRK 732

Query: 662  LRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKE--LHIQGNRLT 835
            LRAL+L +N  + LP  +G+LT L  + LR N L  LP E+GE   LK   L ++ +   
Sbjct: 733  LRALHLGNNVLQSLPSRVGELTSLTQIELRGNRLECLPVELGECPLLKRSGLVVEEDLFN 792

Query: 836  VLPPEL 853
             LPPE+
Sbjct: 793  TLPPEV 798



 Score = 58.9 bits (141), Expect = 5e-09
 Identities = 54/187 (28%), Positives = 80/187 (42%), Gaps = 25/187 (13%)
 Frame = +2

Query: 377  HITQLVLSHNKLTTVPPNIAELKNLEVLNFFNNQIEELPTQISS----LQKLKHLNLGMN 544
            H+T  + + N    V   + ELK L+VL   +N + +LP  ++     LQKL   N G  
Sbjct: 522  HLTGNLSAENNRYIVIDGLRELKRLKVLRLKSN-LSKLPQVVTDVGVHLQKLSINNEGTK 580

Query: 545  R---------------------LNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTT 661
                                  L  +P    SL  L+ +DL  NNL       +F +L  
Sbjct: 581  LIVLNSLKKMANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHR 640

Query: 662  LRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVL 841
            L  L L  N    +P  IG LT L+ L L  N +  +P ++    +L+ L +  N LT L
Sbjct: 641  LTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFL 700

Query: 842  PPELGNL 862
            P ++G L
Sbjct: 701  PADIGLL 707


>ref|XP_003127976.1| PREDICTED: leucine-rich repeat-containing protein 40-like [Sus
           scrofa].
          Length = 602

 Score =  107 bits (266), Expect = 2e-23
 Identities = 70/207 (33%), Positives = 112/207 (54%), Gaps = 1/207 (0%)
 Frame = +2

Query: 359 GLFTLAHITQLVLSHNKLTTVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLG 538
           G   L ++  L LS+N+L+++P + + L ++  LN  +NQ++ LP +IS +++LKHL+  
Sbjct: 169 GFEQLFNLEDLDLSNNRLSSIPASFSSLSSVVRLNISSNQLKSLPAEISGMKRLKHLDCN 228

Query: 539 MNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPD-I 715
            N L T+P    S+ +LE+L L  N L    LP  F     L+ L++ +N  E+L  + +
Sbjct: 229 SNLLETIPPELASMESLELLYLRRNKL--RFLP-EFPSCKLLKELHVGENQIEMLGAEHL 285

Query: 716 GKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNLDLTGQKQIFKA 895
             L  + +L LRDN L S+P EI  L  L+ L +  N ++ LP  LG L L    +    
Sbjct: 286 KHLNSILVLDLRDNKLKSVPDEITLLQSLERLDLSNNDISSLPCSLGKLHL----KFLAL 341

Query: 896 ENNPWVTPIADQFQLGVSHVFEYIRSE 976
           E NP  T   +    G   V +Y+RS+
Sbjct: 342 EGNPLRTIRREIINKGTQEVLKYLRSK 368



 Score =  100 bits (249), Expect = 2e-21
 Identities = 59/158 (37%), Positives = 96/158 (60%)
 Frame = +2

Query: 371 LAHITQLVLSHNKLTTVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRL 550
           L  +T L +  N+LT++P  I EL+NL+ LN  +N+++ LP +I++L+ LK L L  N L
Sbjct: 104 LPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLKILPEEITNLRNLKGLYLQHNEL 163

Query: 551 NTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTK 730
             +P GF  L  LE LDL+ N LS  S+P +F  L+++  L +S N  + LP +I  + +
Sbjct: 164 TCIPEGFEQLFNLEDLDLSNNRLS--SIPASFSSLSSVVRLNISSNQLKSLPAEISGMKR 221

Query: 731 LQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLP 844
           L+ L    N L ++P E+  +  L+ L+++ N+L  LP
Sbjct: 222 LKHLDCNSNLLETIPPELASMESLELLYLRRNKLRFLP 259



 Score = 95.1 bits (235), Expect = 7e-20
 Identities = 56/162 (34%), Positives = 90/162 (55%)
 Frame = +2

Query: 380 ITQLVLSHNKLTTVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTL 559
           +T+L++S+NKL ++  ++  L  L VL+  +NQ+  LP+ I  L+ L+ LN+  N+L  L
Sbjct: 84  LTKLIISNNKLQSLSDDLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLKIL 143

Query: 560 PRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQI 739
           P    +L  L+ L L +N L+   +P  F  L  L  L LS+N    +P     L+ +  
Sbjct: 144 PEEITNLRNLKGLYLQHNELT--CIPEGFEQLFNLEDLDLSNNRLSSIPASFSSLSSVVR 201

Query: 740 LSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNLD 865
           L++  N L SLP EI  + +LK L    N L  +PPEL +++
Sbjct: 202 LNISSNQLKSLPAEISGMKRLKHLDCNSNLLETIPPELASME 243



 Score = 76.3 bits (186), Expect = 3e-14
 Identities = 49/155 (31%), Positives = 81/155 (52%), Gaps = 2/155 (1%)
 Frame = +2

Query: 380 ITQLVLSHNKLTTVPPNIAELKNL-EVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNT 556
           IT +  S N+L  +P  I E+K +   +N   N++  +  ++  LQKL  L+L  N LN+
Sbjct: 427 ITSVNFSKNQLCEIPKRIVEMKEMVSDVNLSFNKLSFISLELCMLQKLTFLDLRNNFLNS 486

Query: 557 LPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGK-LTKL 733
           LP    SL  L+ ++L++N      LP   + + TL  + +S+N    + P   K +  L
Sbjct: 487 LPEEMESLVRLQTINLSFNRFK--ILPEVLYRIPTLETILISNNQVGSVDPQKMKTMENL 544

Query: 734 QILSLRDNDLISLPKEIGELTQLKELHIQGNRLTV 838
             L L++NDL+ +P E+G    L+ L + GN   V
Sbjct: 545 ITLDLQNNDLLQIPPELGNCVNLRTLLLDGNPFRV 579



 Score = 75.9 bits (185), Expect = 4e-14
 Identities = 60/213 (28%), Positives = 105/213 (49%), Gaps = 5/213 (2%)
 Frame = +2

Query: 347  LDVNGLFTLAHITQLVLSHNKLTTVPPNIAELKNLEVL---NFFNNQIEELPTQISSLQK 517
            ++++ + TL     L  S  +   +P  + +     V+   NF  NQ+ E+P +I  +++
Sbjct: 393  VNIHAIITLK---TLDYSDKQTALIPDEVFDAVKSNVITSVNFSKNQLCEIPKRIVEMKE 449

Query: 518  L-KHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDF 694
            +   +NL  N+L+ +      L  L  LDL  N L  NSLP     L  L+ + LS N F
Sbjct: 450  MVSDVNLSFNKLSFISLELCMLQKLTFLDLRNNFL--NSLPEEMESLVRLQTINLSFNRF 507

Query: 695  EILPPDIGKLTKLQILSLRDNDLISL-PKEIGELTQLKELHIQGNRLTVLPPELGNLDLT 871
            +ILP  + ++  L+ + + +N + S+ P+++  +  L  L +Q N L  +PPELGN    
Sbjct: 508  KILPEVLYRIPTLETILISNNQVGSVDPQKMKTMENLITLDLQNNDLLQIPPELGN---C 564

Query: 872  GQKQIFKAENNPWVTPIADQFQLGVSHVFEYIR 970
               +    + NP+  P A     G + + EY+R
Sbjct: 565  VNLRTLLLDGNPFRVPRAAILMKGTAAILEYLR 597



 Score = 61.2 bits (147), Expect = 1e-09
 Identities = 56/223 (25%), Positives = 99/223 (44%), Gaps = 24/223 (10%)
 Frame = +2

Query: 341 NMLDVNGLFTLAHITQLV---LSHNKLTTVPPNIAELKNLEVLNFFNNQIEELPTQISSL 511
           N +++ G   L H+  ++   L  NKL +VP  I  L++LE L+  NN I  LP  +  L
Sbjct: 275 NQIEMLGAEHLKHLNSILVLDLRDNKLKSVPDEITLLQSLERLDLSNNDISSLPCSLGKL 334

Query: 512 QKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPG----------------- 640
             LK L L  N L T+ R   +    EVL    + + ++ L                   
Sbjct: 335 H-LKFLALEGNPLRTIRREIINKGTQEVLKYLRSKIKDDGLSQSDCVTETAMTLPSESRV 393

Query: 641 NFFYLTTLRALYLSDNDFEILPPDIGKLTKLQIL---SLRDNDLISLPKEIGELTQL-KE 808
           N   + TL+ L  SD    ++P ++    K  ++   +   N L  +PK I E+ ++  +
Sbjct: 394 NIHAIITLKTLDYSDKQTALIPDEVFDAVKSNVITSVNFSKNQLCEIPKRIVEMKEMVSD 453

Query: 809 LHIQGNRLTVLPPELGNLDLTGQKQIFKAENNPWVTPIADQFQ 937
           +++  N+L+ +  EL  L    QK  F    N ++  + ++ +
Sbjct: 454 VNLSFNKLSFISLELCML----QKLTFLDLRNNFLNSLPEEME 492



 Score = 57.4 bits (137), Expect = 2e-08
 Identities = 37/121 (30%), Positives = 65/121 (53%)
 Frame = +2

Query: 500 ISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYL 679
           + + +K   LNL    L+ +P+    +  +++ +    NLS ++    ++  T L  L +
Sbjct: 32  LKAARKSGQLNLSGRNLSEVPQCVWRIN-VDIPEEANQNLSFSATE-RWWEQTDLTKLII 89

Query: 680 SDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGN 859
           S+N  + L  D+  L  L +L + DN L SLP  I EL  L++L++  N+L +LP E+ N
Sbjct: 90  SNNKLQSLSDDLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLKILPEEITN 149

Query: 860 L 862
           L
Sbjct: 150 L 150



 Score = 50.8 bits (120), Expect = 1e-06
 Identities = 39/106 (36%), Positives = 52/106 (49%), Gaps = 9/106 (8%)
 Frame = +2

Query: 590 EVLDLTYNNLSEN---SLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDND 760
           E  DLT   +S N   SL  +   L  L  L + DN    LP  I +L  LQ L++  N 
Sbjct: 80  EQTDLTKLIISNNKLQSLSDDLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNK 139

Query: 761 LISLPKEIGELTQLKELHIQGNRLTVLPP------ELGNLDLTGQK 880
           L  LP+EI  L  LK L++Q N LT +P        L +LDL+  +
Sbjct: 140 LKILPEEITNLRNLKGLYLQHNELTCIPEGFEQLFNLEDLDLSNNR 185


>ref|XP_001924728.3| PREDICTED: leucine-rich repeat and calponin homology
           domain-containing protein 2 [Sus scrofa].
          Length = 698

 Score =  102 bits (255), Expect = 3e-22
 Identities = 69/191 (36%), Positives = 105/191 (54%)
 Frame = +2

Query: 395 LSHNKLTTVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFG 574
           LS N+ T +P ++     LE LN ++N I+ +P  I +LQ L +LN+  N L+TLP+   
Sbjct: 52  LSRNRFTEIPSDVWLFAPLETLNLYHNCIKTIPEAIKNLQMLTYLNISRNLLSTLPKYLF 111

Query: 575 SLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRD 754
            LP L+VL L+ N L   S+P     L  L  L +S N+ ++LP  +GKL  L+ L++R 
Sbjct: 112 DLP-LKVLVLSNNKLV--SIPEEIGKLKDLMELDISCNEIQVLPQQMGKLHSLRELNIRR 168

Query: 755 NDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNLDLTGQKQIFKAENNPWVTPIADQF 934
           N+L  LP E+G+L  +K L    N++T +P     L      Q+   +NNP   P A   
Sbjct: 169 NNLHVLPDELGDLPLVK-LDFSCNKVTEIPVCYRKLH---HLQVIILDNNPLQVPPAQIC 224

Query: 935 QLGVSHVFEYI 967
             G  H+F+Y+
Sbjct: 225 LKGKVHIFKYL 235



 Score = 68.9 bits (167), Expect = 5e-12
 Identities = 42/117 (35%), Positives = 67/117 (57%)
 Frame = +2

Query: 389 LVLSHNKLTTVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRG 568
           LVLS+NKL ++P  I +LK+L  L+   N+I+ LP Q+  L  L+ LN+  N L+ LP  
Sbjct: 118 LVLSNNKLVSIPEEIGKLKDLMELDISCNEIQVLPQQMGKLHSLRELNIRRNNLHVLPDE 177

Query: 569 FGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQI 739
            G LP ++ LD + N ++E  +P  +  L  L+ + L +N  ++ P  I    K+ I
Sbjct: 178 LGDLPLVK-LDFSCNKVTE--IPVCYRKLHHLQVIILDNNPLQVPPAQICLKGKVHI 231


>ref|XP_001927528.1| PREDICTED: leucine-rich repeat protein SHOC-2 [Sus scrofa].
          Length = 582

 Score =  102 bits (255), Expect = 3e-22
 Identities = 66/196 (33%), Positives = 104/196 (53%)
 Frame = +2

Query: 275 KLVEESREKNQPEVDMSDRGISNMLDVNGLFTLAHITQLVLSHNKLTTVPPNIAELKNLE 454
           K + + RE+N   +D+S R I  +   + +  L  +T+L L  NKL ++P  +  L NL 
Sbjct: 92  KELNKCREENSMRLDLSKRSIHIL--PSSIKELTQLTELYLYSNKLQSLPAEVGCLVNLM 149

Query: 455 VLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSL 634
            L    N +  LP  + +L+KL+ L+L  N+L  +P     L +L  L L +N ++  ++
Sbjct: 150 TLALSENSLTSLPDSLDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRIT--TV 207

Query: 635 PGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELH 814
             +   L+ L  L + +N  + LP +IG+L  L  L +  N L  LPKEIG  TQ+  L 
Sbjct: 208 EKDIKNLSKLSMLSIRENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLD 267

Query: 815 IQGNRLTVLPPELGNL 862
           +Q N L  LP  +GNL
Sbjct: 268 LQHNELLDLPDTIGNL 283



 Score = 97.1 bits (240), Expect = 2e-20
 Identities = 66/180 (36%), Positives = 90/180 (50%), Gaps = 1/180 (0%)
 Frame = +2

Query: 329 RGISNMLDVNGLFTLAHITQLVLSHNKLTTVPPNI-AELKNLEVLNFFNNQIEELPTQIS 505
           R    +  V G    + I  L + HN++  +P  I +  K L  LN  +NQ+  LP    
Sbjct: 340 RNCFQLYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLDFG 399

Query: 506 SLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSD 685
           +   +  LNL  N+L  +P     L +LEVL L+ N L +  LP     L  LR L L +
Sbjct: 400 TWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKK--LPHGLGNLRKLRELDLEE 457

Query: 686 NDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNLD 865
           N  E LP +I  L  LQ L L +N L +LP+ IG LT L  L +  N LT LP E+G L+
Sbjct: 458 NKLESLPNEIAYLKDLQKLVLTNNQLTTLPRGIGHLTNLTHLGLGENLLTHLPEEIGTLE 517



 Score = 96.3 bits (238), Expect = 3e-20
 Identities = 68/190 (35%), Positives = 110/190 (57%), Gaps = 2/190 (1%)
 Frame = +2

Query: 290 SREKNQPEVDMSDRGISNM-LDVNGLFTLAHITQLVLSHNKLTTVPPNIAELKNLEVLNF 466
           SR K   +++M D  ++++ LD     T   + +L L+ N+LT +P +++ L +LEVL  
Sbjct: 376 SRAKVLSKLNMKDNQLTSLPLDFG---TWTSMVELNLATNQLTKIPEDVSGLVSLEVLIL 432

Query: 467 FNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNF 646
            NN +++LP  + +L+KL+ L+L  N+L +LP     L  L+ L LT N L+  +LP   
Sbjct: 433 SNNLLKKLPHGLGNLRKLRELDLEENKLESLPNEIAYLKDLQKLVLTNNQLT--TLPRGI 490

Query: 647 FYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDN-DLISLPKEIGELTQLKELHIQG 823
            +LT L  L L +N    LP +IG L  L+ L L DN +L SLP E+   ++L  + I+ 
Sbjct: 491 GHLTNLTHLGLGENLLTHLPEEIGTLENLEELYLNDNPNLHSLPFELALCSKLSIMSIEN 550

Query: 824 NRLTVLPPEL 853
             L+ LPP++
Sbjct: 551 CPLSHLPPQI 560



 Score = 79.7 bits (195), Expect = 3e-15
 Identities = 49/164 (29%), Positives = 82/164 (50%)
 Frame = +2

Query: 362 LFTLAHITQLVLSHNKLTTVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGM 541
           ++ L  +T L L  N++TTV  +I  L  L +L+   N+I++LP +I  L  L  L++  
Sbjct: 188 VYRLDSLTTLYLRFNRITTVEKDIKNLSKLSMLSIRENKIKQLPAEIGELCNLITLDVAH 247

Query: 542 NRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGK 721
           N+L  LP+  G+   +  LDL +N L +                         LP  IG 
Sbjct: 248 NQLEHLPKEIGNCTQITNLDLQHNELLD-------------------------LPDTIGN 282

Query: 722 LTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPEL 853
           L+ L  L LR N L ++P+ + + + L+EL+++ N ++ LP  L
Sbjct: 283 LSSLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPESL 326



 Score = 77.0 bits (188), Expect = 2e-14
 Identities = 61/213 (28%), Positives = 96/213 (45%), Gaps = 49/213 (23%)
 Frame = +2

Query: 371 LAHITQLVLSHNKLTTVPPNIAELKNLEVLNFFNNQIEELPTQ----------------- 499
           L+ ++ L +  NK+  +P  I EL NL  L+  +NQ+E LP +                 
Sbjct: 214 LSKLSMLSIRENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNEL 273

Query: 500 ------ISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFF-YLT 658
                 I +L  L  L L  NRL+ +PR      ALE L+L  NN+S  +LP +    L 
Sbjct: 274 LDLPDTIGNLSSLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNIS--TLPESLLSSLV 331

Query: 659 TLRALYLSDNDFEILPP----------------------DIGKLTKLQILS---LRDNDL 763
            L +L L+ N F++ P                         G  ++ ++LS   ++DN L
Sbjct: 332 KLNSLTLARNCFQLYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQL 391

Query: 764 ISLPKEIGELTQLKELHIQGNRLTVLPPELGNL 862
            SLP + G  T + EL++  N+LT +P ++  L
Sbjct: 392 TSLPLDFGTWTSMVELNLATNQLTKIPEDVSGL 424



 Score = 55.1 bits (131), Expect = 8e-08
 Identities = 32/90 (35%), Positives = 50/90 (55%)
 Frame = +2

Query: 596 LDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLP 775
           LDL+  ++  + LP +   LT L  LYL  N  + LP ++G L  L  L+L +N L SLP
Sbjct: 105 LDLSKRSI--HILPSSIKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTSLP 162

Query: 776 KEIGELTQLKELHIQGNRLTVLPPELGNLD 865
             +  L +L+ L ++ N+L  +P  +  LD
Sbjct: 163 DSLDNLKKLRMLDLRHNKLREIPSVVYRLD 192


  Database: RefSeq49_SP.fasta
    Posted date:  Oct 17, 2011  1:42 PM
  Number of letters in database: 11,343,932
  Number of sequences in database:  24,897
  
Lambda     K      H
   0.318    0.134    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 24897
Number of Hits to DB: 31,982,398
Number of extensions: 976538
Number of successful extensions: 4215
Number of sequences better than 1.0e-05: 104
Number of HSP's gapped: 3832
Number of HSP's successfully gapped: 212
Length of query: 402
Length of database: 11,343,932
Length adjustment: 101
Effective length of query: 301
Effective length of database: 8,829,335
Effective search space: 2657629835
Effective search space used: 2657629835
Neighboring words threshold: 12
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 34 (17.7 bits)

BLASTN 2.2.24 [Aug-08-2010]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= 20110601C-000824
         (1206 letters)

Database: Sscrofa_10.2.fasta 
           4582 sequences; 2,808,509,378 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

Sscrofa_Chr10                                                         502   e-139
gb|GL893725.2| Sus scrofa unplaced genomic scaffold ChrUScaf1610      240   1e-60

>Sscrofa_Chr10 
||          Length = 79102373

 Score =  502 bits (253), Expect = e-139
 Identities = 253/253 (100%)
 Strand = Plus / Plus

                                                                            
Query: 3        ttcttttatgggcggagcctcgccctaagccacgtctagtaagctgttttcctaattagg 62
                ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 49812893 ttcttttatgggcggagcctcgccctaagccacgtctagtaagctgttttcctaattagg 49812952

                                                                            
Query: 63       gaagggtcccgcgcgggcggggcgtggagctgagctcgtcccggtgtgcgcttgcgccga 122
                ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 49812953 gaagggtcccgcgcgggcggggcgtggagctgagctcgtcccggtgtgcgcttgcgccga 49813012

                                                                            
Query: 123      gcgccgggacagggcgtgttcctggttcgggtgccgaattcgcaccgaccgagtgcatcg 182
                ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 49813013 gcgccgggacagggcgtgttcctggttcgggtgccgaattcgcaccgaccgagtgcatcg 49813072

                                                                            
Query: 183      ctcgccgccggagtgagccctgcggaatcctgtcatttccacgcccaacctgttaggtgc 242
                ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 49813073 ctcgccgccggagtgagccctgcggaatcctgtcatttccacgcccaacctgttaggtgc 49813132

                             
Query: 243      tgcctttcacagt 255
                |||||||||||||
Sbjct: 49813133 tgcctttcacagt 49813145



 Score =  270 bits (136), Expect = 2e-69
 Identities = 136/136 (100%)
 Strand = Plus / Plus

                                                                            
Query: 852      taggaaacttggatttaactggtcagaagcagatattcaaagcagagaacaacccctggg 911
                ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 49897775 taggaaacttggatttaactggtcagaagcagatattcaaagcagagaacaacccctggg 49897834

                                                                            
Query: 912      ttacccccattgctgaccaattccagcttggcgtgtcccatgtttttgaatatatccgtt 971
                ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 49897835 ttacccccattgctgaccaattccagcttggcgtgtcccatgtttttgaatatatccgtt 49897894

                                
Query: 972      ctgagacctacaaata 987
                ||||||||||||||||
Sbjct: 49897895 ctgagacctacaaata 49897910



 Score =  238 bits (120), Expect = 6e-60
 Identities = 120/120 (100%)
 Strand = Plus / Minus

                                                                            
Query: 537      gcatgaatagactaaacacgctgccgcgaggatttggatccctgccagctctggaggtcc 596
                ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 49844624 gcatgaatagactaaacacgctgccgcgaggatttggatccctgccagctctggaggtcc 49844565

                                                                            
Query: 597      ttgacctgacttataacaacttgagtgaaaattctcttcctggaaacttcttctacctga 656
                ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 49844564 ttgacctgacttataacaacttgagtgaaaattctcttcctggaaacttcttctacctga 49844505



 Score =  230 bits (116), Expect = 1e-57
 Identities = 116/116 (100%)
 Strand = Plus / Minus

                                                                            
Query: 740      ctcagcctcagggataacgacctgatctcgctgcctaaggaaatcggggagcttactcag 799
                ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 49841520 ctcagcctcagggataacgacctgatctcgctgcctaaggaaatcggggagcttactcag 49841461

                                                                        
Query: 800      cttaaggagctccacattcaggggaaccgcctgaccgtgctgcccccagaactagg 855
                ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 49841460 cttaaggagctccacattcaggggaaccgcctgaccgtgctgcccccagaactagg 49841405



 Score =  222 bits (112), Expect = 3e-55
 Identities = 112/112 (100%)
 Strand = Plus / Plus

                                                                            
Query: 254      gtcatgtccaagtctctgaaaaagttggtggaggagagcagagagaagaaccagccggaa 313
                ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 49813394 gtcatgtccaagtctctgaaaaagttggtggaggagagcagagagaagaaccagccggaa 49813453

                                                                    
Query: 314      gtggacatgagtgaccggggcatctccaacatgctggacgtcaacggcttgt 365
                ||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 49813454 gtggacatgagtgaccggggcatctccaacatgctggacgtcaacggcttgt 49813505



 Score =  208 bits (105), Expect = 5e-51
 Identities = 162/181 (89%), Gaps = 2/181 (1%)
 Strand = Plus / Plus

                                                                            
Query: 988      cctctacggcagacacatgcaggcaaacccagaaccgccggaataaaataatgacacatc 1047
                |||||||||||||||||||||||||||||||||||||||| |  |||||||||||| |||
Sbjct: 49996293 cctctacggcagacacatgcaggcaaacccagaaccgccgaagaaaaataatgacaaatc 49996352

                                                                            
Query: 1048     gnnnnnnntcagccggaaacccctgacagccnagaaacaataaagggtccgccatgggct 1107
                |       ||||||||||||||||||||||| ||||  ||||| ||||||||||||||||
Sbjct: 49996353 gaaaaagatcagccggaaacccctgacagccaagaacaaataaggggtccgccatgggct 49996412

                                                                            
Query: 1108     ggacttct-gccgcttctctcatcattctgttgtcccccattctacc-cacatgtgaata 1165
                |||||||| |||||||||||||||||||||||||| | ||||||||| ||||||||||||
Sbjct: 49996413 ggacttctggccgcttctctcatcattctgttgtctctcattctaccacacatgtgaata 49996472

                 
Query: 1166     c 1166
                |
Sbjct: 49996473 c 49996473



 Score =  165 bits (83), Expect = 7e-38
 Identities = 83/83 (100%)
 Strand = Plus / Minus

                                                                            
Query: 657      ccaccctgcgtgcactctatctcagtgacaacgattttgaaatcctgccgcctgatattg 716
                ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 49841887 ccaccctgcgtgcactctatctcagtgacaacgattttgaaatcctgccgcctgatattg 49841828

                                       
Query: 717      ggaagctcaccaagttgcagata 739
                |||||||||||||||||||||||
Sbjct: 49841827 ggaagctcaccaagttgcagata 49841805



 Score =  139 bits (70), Expect = 4e-30
 Identities = 212/256 (82%), Gaps = 10/256 (3%)
 Strand = Plus / Minus

                                                                            
Query: 3        ttcttttatgggcggagcctcgccctaagccacgtctagtaagctgttttcctaattagg 62
                |||||||||||||||||||||||||| ||| || |||||||| |||||   |||||||||
Sbjct: 47740805 ttcttttatgggcggagcctcgccctgagcgacctctagtaaactgtt---ctaattagg 47740749

                                                                            
Query: 63       gaagggtcccgcgcgggcggggcgtggagctgagctcgtcccggtgtgcgcttgcgccga 122
                |||||||   ||||||||||||||||||||||||   | || ||||||||||||||| ||
Sbjct: 47740748 gaagggtggggcgcgggcggggcgtggagctgagactgccctggtgtgcgcttgcgctga 47740689

                                                                            
Query: 123      gcgccgggacagggcgtgttcctggttcgggtgccgaattcgcaccgaccgagtgcatcg 182
                | |  ||||| ||||||||||||||||||  |   |  || |  | |||||||||  || 
Sbjct: 47740688 gag-ggggacggggcgtgttcctggttcgaat---gttttagttcagaccgagtgtttct 47740633

                                                                            
Query: 183      ctcgccgccggagtg---agccctgcggaatcctgtcatttccacgcccaacctgttagg 239
                 |||||||||  |||   |||||||||| |||| ||| ||||||||||||||||||||||
Sbjct: 47740632 gtcgccgccgcggtggaaagccctgcggtatccagtcgtttccacgcccaacctgttagg 47740573

                                
Query: 240      tgctgcctttcacagt 255
                ||||||||||| ||||
Sbjct: 47740572 tgctgcctttcgcagt 47740557



 Score = 71.9 bits (36), Expect = 8e-10
 Identities = 73/84 (86%), Gaps = 1/84 (1%)
 Strand = Plus / Minus

                                                                            
Query: 282      tggaggagagcagagagaagaaccagccggaagtggacatgagtgaccggggcatctcca 341
                ||||||| ||| | || ||| |||||||||| || ||| |||| ||||||||||||||||
Sbjct: 47740227 tggaggaaagctgggaaaaggaccagccggaggtagacgtgagcgaccggggcatctcca 47740168

                                        
Query: 342      acatgctggacgtcaacggcttgt 365
                ||||||| ||||||| ||||||||
Sbjct: 47740167 acatgct-gacgtcagcggcttgt 47740145


>gb|GL893725.2| Sus scrofa unplaced genomic scaffold ChrUScaf1610
          Length = 33613

 Score =  240 bits (121), Expect = 1e-60
 Identities = 121/121 (100%)
 Strand = Plus / Plus

                                                                         
Query: 417   ctgtgccacccaacatagcagaactgaagaatttggaagtgctcaacttttttaacaacc 476
             ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 22588 ctgtgccacccaacatagcagaactgaagaatttggaagtgctcaacttttttaacaacc 22647

                                                                         
Query: 477   agattgaggagctgcccacgcagatcagcagccttcagaaactcaaacacctgaaccttg 536
             ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 22648 agattgaggagctgcccacgcagatcagcagccttcagaaactcaaacacctgaaccttg 22707

              
Query: 537   g 537
             |
Sbjct: 22708 g 22708



 Score =  238 bits (120), Expect = 6e-60
 Identities = 120/120 (100%)
 Strand = Plus / Plus

                                                                         
Query: 537   gcatgaatagactaaacacgctgccgcgaggatttggatccctgccagctctggaggtcc 596
             ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 30401 gcatgaatagactaaacacgctgccgcgaggatttggatccctgccagctctggaggtcc 30460

                                                                         
Query: 597   ttgacctgacttataacaacttgagtgaaaattctcttcctggaaacttcttctacctga 656
             ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 30461 ttgacctgacttataacaacttgagtgaaaattctcttcctggaaacttcttctacctga 30520



 Score =  230 bits (116), Expect = 1e-57
 Identities = 116/116 (100%)
 Strand = Plus / Plus

                                                                         
Query: 740   ctcagcctcagggataacgacctgatctcgctgcctaaggaaatcggggagcttactcag 799
             ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 32926 ctcagcctcagggataacgacctgatctcgctgcctaaggaaatcggggagcttactcag 32985

                                                                     
Query: 800   cttaaggagctccacattcaggggaaccgcctgaccgtgctgcccccagaactagg 855
             ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 32986 cttaaggagctccacattcaggggaaccgcctgaccgtgctgcccccagaactagg 33041



 Score =  165 bits (83), Expect = 7e-38
 Identities = 83/83 (100%)
 Strand = Plus / Plus

                                                                         
Query: 657   ccaccctgcgtgcactctatctcagtgacaacgattttgaaatcctgccgcctgatattg 716
             ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 32559 ccaccctgcgtgcactctatctcagtgacaacgattttgaaatcctgccgcctgatattg 32618

                                    
Query: 717   ggaagctcaccaagttgcagata 739
             |||||||||||||||||||||||
Sbjct: 32619 ggaagctcaccaagttgcagata 32641



 Score =  101 bits (51), Expect = 9e-19
 Identities = 51/51 (100%)
 Strand = Plus / Plus

                                                               
Query: 366  tcaccctggcccacatcacacagctggtcctcagccacaacaagctgacaa 416
            |||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 2267 tcaccctggcccacatcacacagctggtcctcagccacaacaagctgacaa 2317


  Database: Sscrofa_10.2.fasta
    Posted date:  Nov 16, 2011 10:34 AM
  Number of letters in database: 2,808,509,378
  Number of sequences in database:  4582
  
Lambda     K      H
    1.37    0.711     1.31 

Gapped
Lambda     K      H
    1.37    0.711     1.31 


Matrix: blastn matrix:1 -3
Gap Penalties: Existence: 5, Extension: 2
Number of Sequences: 4582
Number of Hits to DB: 31,251,089
Number of extensions: 182
Number of successful extensions: 182
Number of sequences better than 1.0e-05: 2
Number of HSP's gapped: 178
Number of HSP's successfully gapped: 15
Length of query: 1206
Length of database: 2,808,509,378
Length adjustment: 21
Effective length of query: 1185
Effective length of database: 2,808,413,156
Effective search space: 3327969589860
Effective search space used: 3327969589860
X1: 11 (21.8 bits)
X2: 15 (29.7 bits)
X3: 50 (99.1 bits)
S1: 18 (36.2 bits)
S2: 30 (60.0 bits)