Animal-Genome cDNA 20110601C-002457

BLASTX 2.2.24 [Aug-08-2010]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= 20110601C-002457
         (2728 letters)

Database: RefSeq49_BP.fasta 
           33,088 sequences; 17,681,374 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

Alignment   gi|XP_002686235.1| PREDICTED: sortilin 1 [Bos taurus].              1488   0.0  
Alignment   gi|XP_002703936.1| PREDICTED: sortilin 1 [Bos taurus].              1488   0.0  
Alignment   gi|NP_001179686.1| sortilin-related receptor [Bos taurus].           239   1e-62
Alignment   gi|XP_002693133.1| PREDICTED: sortilin-related receptor, L(DLR ...   239   1e-62
Alignment   gi|NP_001178136.2| VPS10 domain-containing receptor SorCS1 [Bos...   224   2e-58
Alignment   gi|NP_001192915.1| VPS10 domain-containing receptor SorCS3 [Bos...   207   3e-53
Alignment   gi|XP_002698518.1| PREDICTED: sortilin-related VPS10 domain con...   207   3e-53
Alignment   gi|XP_002698566.1| PREDICTED: sortilin-related VPS10 domain con...   190   5e-48

>ref|XP_002686235.1| PREDICTED: sortilin 1 [Bos taurus].
          Length = 921

 Score = 1488 bits (3852), Expect = 0.0
 Identities = 730/817 (89%), Positives = 746/817 (91%)
 Frame = +1

Query: 64   GAAQGLSRWPHGLGXXXXXXXXLLPPASLGQDRLDXXXXXXXXLSRWSGPVGVSWGLXXX 243
            GAA  LSRWPHGLG        LLPPA+LGQDRLD        LSRWSGPVGVSWGL   
Sbjct: 95   GAADSLSRWPHGLGLLLFLLQ-LLPPATLGQDRLDAPPPPAAPLSRWSGPVGVSWGLRAA 153

Query: 244  XXXXXXXXXXXWRRSALDEDEDCGGVRDFVARLANNTHQHVFDDLSGSVSLSWVGDSTGI 423
                       WRRSA  EDEDCGGV+DFV+RLANNTHQHVFDDLSGSVSLSWVGDSTGI
Sbjct: 154  APGGPAPRGGRWRRSAPGEDEDCGGVQDFVSRLANNTHQHVFDDLSGSVSLSWVGDSTGI 213

Query: 424  ILVLTTFHVPLVIMTFGQSKLYRSEDYGKNFKDITNLINNTFIRTEFGMAIGPENSGKVI 603
            ILVLTTFHVPLVIMTFGQSKLYRSEDYGKNFKDITNLINNTFIRTEFGMAIGPENSGKVI
Sbjct: 214  ILVLTTFHVPLVIMTFGQSKLYRSEDYGKNFKDITNLINNTFIRTEFGMAIGPENSGKVI 273

Query: 604  LTAEVSGGSHGGRIFRSSDFAKNFIQTNLPFHPLTQMMYSPQNSDHLLALSTENGLWVSK 783
            LTAEVSGGSHGGRIFRSSDFAKNF+QTNLPFHPLTQMMYSPQNSD+LLALSTENGLWVSK
Sbjct: 274  LTAEVSGGSHGGRIFRSSDFAKNFVQTNLPFHPLTQMMYSPQNSDYLLALSTENGLWVSK 333

Query: 784  NFGGKWEEIHKAVCLAKWGSDSTIFFTTYVNGSCKADLGALELRRTSDLGKSFKTIGVKI 963
            NFGGKWEEIHKAVCLAKWGS++ IFFTTYVNGSCKADLGALELRRTSDLGKSFKTIGVKI
Sbjct: 334  NFGGKWEEIHKAVCLAKWGSENIIFFTTYVNGSCKADLGALELRRTSDLGKSFKTIGVKI 393

Query: 964  YSFGLGGRFLFASVMADKDTTRRIHVSTDQGDTWSMAQLPSVGQEQFYSILAANDDMVFM 1143
            YSFGLGGRFLFASVMADKDTTRRIHVSTDQGDTWSMAQLPSVGQEQFYSILAANDDMVFM
Sbjct: 394  YSFGLGGRFLFASVMADKDTTRRIHVSTDQGDTWSMAQLPSVGQEQFYSILAANDDMVFM 453

Query: 1144 HVDEPGDTGFGTIFTSDDRGIVYSKSLDRHLYTTTGGETDFTNVTSLRGVYMTSVLSEDN 1323
            HVDEPGDTGFGTIFTSDDRGIVYSKSLDRHLYTTTGGETDFTNVTSLRGVYMTSVLSEDN
Sbjct: 454  HVDEPGDTGFGTIFTSDDRGIVYSKSLDRHLYTTTGGETDFTNVTSLRGVYMTSVLSEDN 513

Query: 1324 SIQTMITFDQGGRWKHLRKPENSECDATAKNKNECSLHIHASYSISQKLNVPMAPLSEPN 1503
            SIQTMITFDQGGRWKHLRKPENSECDATAKNKNECSLHIHASYSISQKLNVPMAPLSEPN
Sbjct: 514  SIQTMITFDQGGRWKHLRKPENSECDATAKNKNECSLHIHASYSISQKLNVPMAPLSEPN 573

Query: 1504 AVGIVIAHGSVGDAISVMIPDVYISDDGGYSWLKMLEGPHYYTILDSGGIIVAIEHSSHP 1683
            AVGIVIAHGSVGDAISVM+PDVYISDDGGYSW+KMLEGPHYYTILDSGGIIVAIEHSSHP
Sbjct: 574  AVGIVIAHGSVGDAISVMVPDVYISDDGGYSWMKMLEGPHYYTILDSGGIIVAIEHSSHP 633

Query: 1684 INVIKFSTDEGQCWQTYVFSREPIYFTGLASEPGARSMNISIWGFTESFLTRQWVSYTID 1863
            INVIKFSTDEGQCWQTY F++EPIYFTGLASEPGARSMNISIWGFTESFL RQWVSYTID
Sbjct: 634  INVIKFSTDEGQCWQTYTFTKEPIYFTGLASEPGARSMNISIWGFTESFLARQWVSYTID 693

Query: 1864 FKDILERNCEEKDYTVWLAHSTDPGDYGDGCILGYKEQYLRLRKSSVCQNGRDYVVTKQP 2043
            FKDILERNCEEKDYT+WLAHSTDPGDYGDGCILGYKEQYLRLRKSSVCQNGR+YVVTKQP
Sbjct: 694  FKDILERNCEEKDYTIWLAHSTDPGDYGDGCILGYKEQYLRLRKSSVCQNGRNYVVTKQP 753

Query: 2044 SVCPCSLEDFLCDFGYFRPENDSKCVEQPELKGHDLEFCLYGREEHLTTNGYRKIPGDRC 2223
            SVCPCSLEDFLCDFGYFRPENDSKCVEQPELKGHDLEFCLYGREEHLTTNGYRKIPGD+C
Sbjct: 754  SVCPCSLEDFLCDFGYFRPENDSKCVEQPELKGHDLEFCLYGREEHLTTNGYRKIPGDKC 813

Query: 2224 QGGVNPAREVKDLKKKCTSNFLSPEKQDSRPQGHNLSQNPAPPPLGYTENTHSLSPTQKQ 2403
            QGGVNP REVKDLKKKCTSNFLSPE                                 KQ
Sbjct: 814  QGGVNPVREVKDLKKKCTSNFLSPE---------------------------------KQ 840

Query: 2404 NSKSSSVPIILATVGLMLVTVVAGVLIVKKYVCGGRF 2514
            NSKS+SVPIILATVGLMLVTV+AGVLIVKKYVCGGRF
Sbjct: 841  NSKSNSVPIILATVGLMLVTVIAGVLIVKKYVCGGRF 877



 Score = 57.8 bits (138), Expect(2) = 4e-13
 Identities = 27/30 (90%), Positives = 28/30 (93%)
 Frame = +3

Query: 2505 GKVLVHRYSVLQQHAEANGVDGVDALDTPS 2594
            G+ LVHRYSVLQQHAEANGVDGVDALDT S
Sbjct: 875  GRFLVHRYSVLQQHAEANGVDGVDALDTAS 904



 Score = 37.0 bits (84), Expect(2) = 4e-13
 Identities = 16/18 (88%), Positives = 16/18 (88%)
 Frame = +2

Query: 2588 ALHTTKSGYHDDSDEDLL 2641
            A HT KSGYHDDSDEDLL
Sbjct: 903  ASHTHKSGYHDDSDEDLL 920


>ref|XP_002703936.1| PREDICTED: sortilin 1 [Bos taurus].
          Length = 921

 Score = 1488 bits (3852), Expect = 0.0
 Identities = 730/817 (89%), Positives = 746/817 (91%)
 Frame = +1

Query: 64   GAAQGLSRWPHGLGXXXXXXXXLLPPASLGQDRLDXXXXXXXXLSRWSGPVGVSWGLXXX 243
            GAA  LSRWPHGLG        LLPPA+LGQDRLD        LSRWSGPVGVSWGL   
Sbjct: 95   GAADSLSRWPHGLGLLLFLLQ-LLPPATLGQDRLDAPPPPAAPLSRWSGPVGVSWGLRAA 153

Query: 244  XXXXXXXXXXXWRRSALDEDEDCGGVRDFVARLANNTHQHVFDDLSGSVSLSWVGDSTGI 423
                       WRRSA  EDEDCGGV+DFV+RLANNTHQHVFDDLSGSVSLSWVGDSTGI
Sbjct: 154  APGGPAPRGGRWRRSAPGEDEDCGGVQDFVSRLANNTHQHVFDDLSGSVSLSWVGDSTGI 213

Query: 424  ILVLTTFHVPLVIMTFGQSKLYRSEDYGKNFKDITNLINNTFIRTEFGMAIGPENSGKVI 603
            ILVLTTFHVPLVIMTFGQSKLYRSEDYGKNFKDITNLINNTFIRTEFGMAIGPENSGKVI
Sbjct: 214  ILVLTTFHVPLVIMTFGQSKLYRSEDYGKNFKDITNLINNTFIRTEFGMAIGPENSGKVI 273

Query: 604  LTAEVSGGSHGGRIFRSSDFAKNFIQTNLPFHPLTQMMYSPQNSDHLLALSTENGLWVSK 783
            LTAEVSGGSHGGRIFRSSDFAKNF+QTNLPFHPLTQMMYSPQNSD+LLALSTENGLWVSK
Sbjct: 274  LTAEVSGGSHGGRIFRSSDFAKNFVQTNLPFHPLTQMMYSPQNSDYLLALSTENGLWVSK 333

Query: 784  NFGGKWEEIHKAVCLAKWGSDSTIFFTTYVNGSCKADLGALELRRTSDLGKSFKTIGVKI 963
            NFGGKWEEIHKAVCLAKWGS++ IFFTTYVNGSCKADLGALELRRTSDLGKSFKTIGVKI
Sbjct: 334  NFGGKWEEIHKAVCLAKWGSENIIFFTTYVNGSCKADLGALELRRTSDLGKSFKTIGVKI 393

Query: 964  YSFGLGGRFLFASVMADKDTTRRIHVSTDQGDTWSMAQLPSVGQEQFYSILAANDDMVFM 1143
            YSFGLGGRFLFASVMADKDTTRRIHVSTDQGDTWSMAQLPSVGQEQFYSILAANDDMVFM
Sbjct: 394  YSFGLGGRFLFASVMADKDTTRRIHVSTDQGDTWSMAQLPSVGQEQFYSILAANDDMVFM 453

Query: 1144 HVDEPGDTGFGTIFTSDDRGIVYSKSLDRHLYTTTGGETDFTNVTSLRGVYMTSVLSEDN 1323
            HVDEPGDTGFGTIFTSDDRGIVYSKSLDRHLYTTTGGETDFTNVTSLRGVYMTSVLSEDN
Sbjct: 454  HVDEPGDTGFGTIFTSDDRGIVYSKSLDRHLYTTTGGETDFTNVTSLRGVYMTSVLSEDN 513

Query: 1324 SIQTMITFDQGGRWKHLRKPENSECDATAKNKNECSLHIHASYSISQKLNVPMAPLSEPN 1503
            SIQTMITFDQGGRWKHLRKPENSECDATAKNKNECSLHIHASYSISQKLNVPMAPLSEPN
Sbjct: 514  SIQTMITFDQGGRWKHLRKPENSECDATAKNKNECSLHIHASYSISQKLNVPMAPLSEPN 573

Query: 1504 AVGIVIAHGSVGDAISVMIPDVYISDDGGYSWLKMLEGPHYYTILDSGGIIVAIEHSSHP 1683
            AVGIVIAHGSVGDAISVM+PDVYISDDGGYSW+KMLEGPHYYTILDSGGIIVAIEHSSHP
Sbjct: 574  AVGIVIAHGSVGDAISVMVPDVYISDDGGYSWMKMLEGPHYYTILDSGGIIVAIEHSSHP 633

Query: 1684 INVIKFSTDEGQCWQTYVFSREPIYFTGLASEPGARSMNISIWGFTESFLTRQWVSYTID 1863
            INVIKFSTDEGQCWQTY F++EPIYFTGLASEPGARSMNISIWGFTESFL RQWVSYTID
Sbjct: 634  INVIKFSTDEGQCWQTYTFTKEPIYFTGLASEPGARSMNISIWGFTESFLARQWVSYTID 693

Query: 1864 FKDILERNCEEKDYTVWLAHSTDPGDYGDGCILGYKEQYLRLRKSSVCQNGRDYVVTKQP 2043
            FKDILERNCEEKDYT+WLAHSTDPGDYGDGCILGYKEQYLRLRKSSVCQNGR+YVVTKQP
Sbjct: 694  FKDILERNCEEKDYTIWLAHSTDPGDYGDGCILGYKEQYLRLRKSSVCQNGRNYVVTKQP 753

Query: 2044 SVCPCSLEDFLCDFGYFRPENDSKCVEQPELKGHDLEFCLYGREEHLTTNGYRKIPGDRC 2223
            SVCPCSLEDFLCDFGYFRPENDSKCVEQPELKGHDLEFCLYGREEHLTTNGYRKIPGD+C
Sbjct: 754  SVCPCSLEDFLCDFGYFRPENDSKCVEQPELKGHDLEFCLYGREEHLTTNGYRKIPGDKC 813

Query: 2224 QGGVNPAREVKDLKKKCTSNFLSPEKQDSRPQGHNLSQNPAPPPLGYTENTHSLSPTQKQ 2403
            QGGVNP REVKDLKKKCTSNFLSPE                                 KQ
Sbjct: 814  QGGVNPVREVKDLKKKCTSNFLSPE---------------------------------KQ 840

Query: 2404 NSKSSSVPIILATVGLMLVTVVAGVLIVKKYVCGGRF 2514
            NSKS+SVPIILATVGLMLVTV+AGVLIVKKYVCGGRF
Sbjct: 841  NSKSNSVPIILATVGLMLVTVIAGVLIVKKYVCGGRF 877



 Score = 57.8 bits (138), Expect(2) = 4e-13
 Identities = 27/30 (90%), Positives = 28/30 (93%)
 Frame = +3

Query: 2505 GKVLVHRYSVLQQHAEANGVDGVDALDTPS 2594
            G+ LVHRYSVLQQHAEANGVDGVDALDT S
Sbjct: 875  GRFLVHRYSVLQQHAEANGVDGVDALDTAS 904



 Score = 37.0 bits (84), Expect(2) = 4e-13
 Identities = 16/18 (88%), Positives = 16/18 (88%)
 Frame = +2

Query: 2588 ALHTTKSGYHDDSDEDLL 2641
            A HT KSGYHDDSDEDLL
Sbjct: 903  ASHTHKSGYHDDSDEDLL 920


>ref|NP_001179686.1| sortilin-related receptor [Bos taurus].
          Length = 2211

 Score =  239 bits (609), Expect = 1e-62
 Identities = 191/666 (28%), Positives = 317/666 (47%), Gaps = 45/666 (6%)
 Frame = +1

Query: 370  DDLSGSVSLSWVGDSTGIILVLTTFHVPLVIMTFGQSKLYRSEDYGKNFKDITNLIN--- 540
            +D    + + W G+ + +I+ L      L +     S +Y S DYG++FK I+  +N   
Sbjct: 96   NDSHNQMVVHWAGEKSNVIVALA--RDSLALAKPKSSDVYVSYDYGRSFKRISEKLNFGE 153

Query: 541  -NTFIRTEFGMAIGPENSGKVILTAEVSGGSHGGRIFRSSDFAKNFIQTNLPFHPLTQMM 717
             N+           P ++ + I T      ++   ++ + DF       ++PF     ++
Sbjct: 154  GNSSEAVIAQFYHSPADNKRYIFT-----DAYAQYLWTTFDFCNTIQGFSIPFRAADLLL 208

Query: 718  YSPQNSDHLLALSTENG---LWVSKNFGGKWEEIHKAVCLAKWGSD-----STIFFTTYV 873
            +S + S+ LL     +    LW S +FG  W  I + V    WG D     +TI+   + 
Sbjct: 209  HS-KASNLLLGFDRSHPNKQLWKSDDFGQTWIMIQEHVKSVSWGIDPYDKPNTIYVERHE 267

Query: 874  NGSCKADLGALELRRTSDLGKSFKTIGV---KIYSFGLGGRFLFASVM-----ADKDTTR 1029
                    G   + R++D  +S + + V   ++  F L  +++FA+ +     + + ++ 
Sbjct: 268  PS------GYSTVFRSTDFFQSRENLEVILEEVRDFQLRDKYMFATKVVHLFGSPQPSSV 321

Query: 1030 RIHVSTDQGDTWSMAQLPSVGQEQFYSILAANDDMVFMHVDEPGDTGFGTIFTSDDRGIV 1209
            ++ VS  +      AQ  +      Y I  A++D VF+ V    +     ++ S+  G+ 
Sbjct: 322  QLWVSFGR-KPMRAAQFVTRHPINEYYIADASEDQVFVCVSHSNNRT--NLYISEAEGLK 378

Query: 1210 YSKSLDRHLYTTTGGE--------------TDFTNVTSLRGVYMTSVLS---EDNSIQTM 1338
            +S SL+  LY +  G                DF  V  L+GVY+ +++S    + +++++
Sbjct: 379  FSLSLENVLYYSPAGAGSDTLVRYFANEPFADFHRVEGLQGVYIATLISGSMNEENMRSV 438

Query: 1339 ITFDQGGRWKHLRKPENSECDA--TAKNKNECSLHIHASYSISQKLNVPMAP-LSEPNAV 1509
            ITFD+GG W+ L+ P  +E       +    CSLH+    S    L +   P LS+ +A 
Sbjct: 439  ITFDKGGTWEFLQAPAFTEYGEKINCELSQGCSLHLAQRLSQLLSLQLRRMPILSKESAP 498

Query: 1510 GIVIAHGSVGDAISVMIPDVYISDDGGYSWLKMLEGPHYYTILDSGGIIVAIEHSSHPIN 1689
            G++IA GSVG  ++    +VYIS   G  W + L GPHYYT  D GGII+AI       N
Sbjct: 499  GLIIATGSVGKNLASKT-NVYISSSAGARWREALPGPHYYTWGDHGGIIMAIAQGMET-N 556

Query: 1690 VIKFSTDEGQCWQTYVFSREPIYFTGLASEPGARSMNISIWGFTESFLTRQWVSYTIDFK 1869
             +K+ST+EG+ W+T+VFS EP++  GL +EPG +S   +I+G  +  +   W+   ++  
Sbjct: 557  ELKYSTNEGETWKTFVFSEEPVFVYGLLTEPGEKSTVFTIFGSNKENI-HSWLILQVNAT 615

Query: 1870 DILERNCEEKDYTVWLAHSTDPGDYGDGCILGYKEQYLRLRKSSVCQNGRDYVVTKQPSV 2049
              L   C E DY +W    +   + G+ C+LG+K  + R    + C NG D+      S 
Sbjct: 616  SALGVPCTENDYKLW----SPSDERGNECLLGHKTVFKRRTPHATCFNGEDFDRPVVVSN 671

Query: 2050 CPCSLEDFLCDFGYFRPENDS--KCVEQPELKGHDLE---FCLYGREEHLTTNGYRKIPG 2214
            C C+ ED+ CDFG+   E+ S   CV  PE  G+       C  G   +  T GYRKI G
Sbjct: 672  CSCTREDYECDFGFKMSEDLSLEVCVPDPEFSGNSFAPPVPCPVG-STYRRTRGYRKISG 730

Query: 2215 DRCQGG 2232
            D C GG
Sbjct: 731  DTCSGG 736


>ref|XP_002693133.1| PREDICTED: sortilin-related receptor, L(DLR class) A
            repeats-containing [Bos taurus].
          Length = 2310

 Score =  239 bits (609), Expect = 1e-62
 Identities = 191/666 (28%), Positives = 317/666 (47%), Gaps = 45/666 (6%)
 Frame = +1

Query: 370  DDLSGSVSLSWVGDSTGIILVLTTFHVPLVIMTFGQSKLYRSEDYGKNFKDITNLIN--- 540
            +D    + + W G+ + +I+ L      L +     S +Y S DYG++FK I+  +N   
Sbjct: 195  NDSHNQMVVHWAGEKSNVIVALA--RDSLALAKPKSSDVYVSYDYGRSFKRISEKLNFGE 252

Query: 541  -NTFIRTEFGMAIGPENSGKVILTAEVSGGSHGGRIFRSSDFAKNFIQTNLPFHPLTQMM 717
             N+           P ++ + I T      ++   ++ + DF       ++PF     ++
Sbjct: 253  GNSSEAVIAQFYHSPADNKRYIFT-----DAYAQYLWTTFDFCNTIQGFSIPFRAADLLL 307

Query: 718  YSPQNSDHLLALSTENG---LWVSKNFGGKWEEIHKAVCLAKWGSD-----STIFFTTYV 873
            +S + S+ LL     +    LW S +FG  W  I + V    WG D     +TI+   + 
Sbjct: 308  HS-KASNLLLGFDRSHPNKQLWKSDDFGQTWIMIQEHVKSVSWGIDPYDKPNTIYVERHE 366

Query: 874  NGSCKADLGALELRRTSDLGKSFKTIGV---KIYSFGLGGRFLFASVM-----ADKDTTR 1029
                    G   + R++D  +S + + V   ++  F L  +++FA+ +     + + ++ 
Sbjct: 367  PS------GYSTVFRSTDFFQSRENLEVILEEVRDFQLRDKYMFATKVVHLFGSPQPSSV 420

Query: 1030 RIHVSTDQGDTWSMAQLPSVGQEQFYSILAANDDMVFMHVDEPGDTGFGTIFTSDDRGIV 1209
            ++ VS  +      AQ  +      Y I  A++D VF+ V    +     ++ S+  G+ 
Sbjct: 421  QLWVSFGR-KPMRAAQFVTRHPINEYYIADASEDQVFVCVSHSNNRT--NLYISEAEGLK 477

Query: 1210 YSKSLDRHLYTTTGGE--------------TDFTNVTSLRGVYMTSVLS---EDNSIQTM 1338
            +S SL+  LY +  G                DF  V  L+GVY+ +++S    + +++++
Sbjct: 478  FSLSLENVLYYSPAGAGSDTLVRYFANEPFADFHRVEGLQGVYIATLISGSMNEENMRSV 537

Query: 1339 ITFDQGGRWKHLRKPENSECDA--TAKNKNECSLHIHASYSISQKLNVPMAP-LSEPNAV 1509
            ITFD+GG W+ L+ P  +E       +    CSLH+    S    L +   P LS+ +A 
Sbjct: 538  ITFDKGGTWEFLQAPAFTEYGEKINCELSQGCSLHLAQRLSQLLSLQLRRMPILSKESAP 597

Query: 1510 GIVIAHGSVGDAISVMIPDVYISDDGGYSWLKMLEGPHYYTILDSGGIIVAIEHSSHPIN 1689
            G++IA GSVG  ++    +VYIS   G  W + L GPHYYT  D GGII+AI       N
Sbjct: 598  GLIIATGSVGKNLASKT-NVYISSSAGARWREALPGPHYYTWGDHGGIIMAIAQGMET-N 655

Query: 1690 VIKFSTDEGQCWQTYVFSREPIYFTGLASEPGARSMNISIWGFTESFLTRQWVSYTIDFK 1869
             +K+ST+EG+ W+T+VFS EP++  GL +EPG +S   +I+G  +  +   W+   ++  
Sbjct: 656  ELKYSTNEGETWKTFVFSEEPVFVYGLLTEPGEKSTVFTIFGSNKENI-HSWLILQVNAT 714

Query: 1870 DILERNCEEKDYTVWLAHSTDPGDYGDGCILGYKEQYLRLRKSSVCQNGRDYVVTKQPSV 2049
              L   C E DY +W    +   + G+ C+LG+K  + R    + C NG D+      S 
Sbjct: 715  SALGVPCTENDYKLW----SPSDERGNECLLGHKTVFKRRTPHATCFNGEDFDRPVVVSN 770

Query: 2050 CPCSLEDFLCDFGYFRPENDS--KCVEQPELKGHDLE---FCLYGREEHLTTNGYRKIPG 2214
            C C+ ED+ CDFG+   E+ S   CV  PE  G+       C  G   +  T GYRKI G
Sbjct: 771  CSCTREDYECDFGFKMSEDLSLEVCVPDPEFSGNSFAPPVPCPVG-STYRRTRGYRKISG 829

Query: 2215 DRCQGG 2232
            D C GG
Sbjct: 830  DTCSGG 835


>ref|NP_001178136.2| VPS10 domain-containing receptor SorCS1 [Bos taurus].
          Length = 1198

 Score =  224 bits (572), Expect = 2e-58
 Identities = 173/692 (25%), Positives = 321/692 (46%), Gaps = 26/692 (3%)
 Frame = +1

Query: 337  RLANNTHQHVFDDLSGSVSLSWVGDSTGIILVLTT-FHVPLVIMTFGQSKLYRSEDYGKN 513
            +L + T     D       + W G ++ +IL+LT  F   L  +T  +S L+RS DYG  
Sbjct: 159  KLTSTTFALTGDSAHNQAMVHWSGHNSSVILILTKLFDYNLGSIT--ESSLWRSTDYGTT 216

Query: 514  FKDITNLINNTFIRTEFGMAIGPENSGKVILTAEVSGGSHGGRIFRSSDFAKNFIQTNLP 693
            ++ + + +    I +   + + P N  K++L  +    S    +  SSD    + +  L 
Sbjct: 217  YEKLNDKVGLKTILSY--LYVCPTNKRKIMLLTDPEIESS---LLISSDEGATYQKYRLN 271

Query: 694  FHPLTQMMYSPQNSDHLLALSTENGLWVSKNFGGKWEEIHKAVCLAKWGSDSTIFFTTYV 873
            F+ +  +++ P+  D +LA S +  L+ S  FG +W+ I +AV   +       F+ + +
Sbjct: 272  FY-IQSLLFHPKQEDWILAYSQDQKLYSSAEFGRRWQLIQEAVVPNR-------FYWSVM 323

Query: 874  NGSCKADLGALELRRTSDLGKSFKTIGVKIYSFGLGGRFLFASVMADKDTTRRIHVSTD- 1050
              + + DL  LE R T D    + T  ++  +     +     +  D    +  +V    
Sbjct: 324  GSNKEPDLVHLEAR-TVDGHSQYLTCRMQNCTEANRNKPFPGYIDPDSLIVQDDYVFVQL 382

Query: 1051 ------------QGDTWSMAQLPSVGQEQFYSILAANDDMVFMHVDEPGDTGFGTIFTSD 1194
                        + + ++  +LP     +   +++ +++ VF  V E        ++ SD
Sbjct: 383  TSGGRPHYYVSYRRNAFAQMKLPKYALPKDMHVISTDENQVFAAVQEWNQNDTYNLYISD 442

Query: 1195 DRGIVYSKSLDRHLYTTTGGE----TDFTNVTSLRGVYMTSVLSEDNSIQTMITFDQGGR 1362
             RG+ ++ +L+ ++ ++ G E     D   V  ++G+++ +    DN ++T IT+++G  
Sbjct: 443  TRGVYFTLALE-NVQSSRGPEGNVMIDLYEVAGIKGMFLANK-KIDNQVKTFITYNKGRD 500

Query: 1363 WKHLRKPENS-ECDATAKNKNECSLHIHASYSISQKLNVPMAPLSEPNAVGIVIAHGSVG 1539
            W+ L+ P+     D        CSLH+H   S +   +  +A  S   A  I++A G++G
Sbjct: 501  WRLLQAPDTDLRGDPVHCVLPYCSLHLHLKVSENPYTSGIIA--SRDTAPSIIVASGNIG 558

Query: 1540 DAISVMIPDVYISDDGGYSWLKMLEGPHYYTILDSGGIIVAIEHSSHPINVIKFSTDEGQ 1719
              +S     +++S D G +W ++ E  H    LD GG++VA++H+S PI  +  S DEG+
Sbjct: 559  SELSDSDISMFVSSDAGNTWRQIFEEEHSVLYLDQGGVLVAMKHTSLPIRHLWLSFDEGR 618

Query: 1720 CWQTYVFSREPIYFTGLASEPGARSMNISIWGFTESFLTRQWVSYTIDFKDILERNCEEK 1899
             W  Y F+  P++  G+  EPG  ++ ++++G        +W    +D+K I +R C E+
Sbjct: 619  SWSKYSFTSIPLFVDGVLGEPGEETLIMTVFGHFSH--RSEWQLVKVDYKSIFDRRCAEE 676

Query: 1900 DYTVWLAHSTDPGDYGDGCILGYKEQYLRLRKSSVCQNGRDYVVTKQPSVCPCSLEDFLC 2079
            DY  W  HS      G+ CI+G K  Y + +    C  G+ Y    +   C C+  DF C
Sbjct: 677  DYRPWQLHS-----QGEACIMGAKRIYKKRKSERKCMQGK-YAGAMESEPCVCTEADFDC 730

Query: 2080 DFGYFRPENDSKCVEQPELKGHDL-EFCLYGREEHLTTNGYRKIPGDRCQGGVNPAREVK 2256
            D+GY R  N  +C+         L + C  G + +L + GYRK+  + C  GV      K
Sbjct: 731  DYGYERHSN-GQCLPAFWFNPSSLSKDCSLG-QSYLNSTGYRKVVSNNCTDGVREQYTAK 788

Query: 2257 DLKKKCTS------NFLSPEKQDSRPQGHNLS 2334
               +KC          ++ + + +  QGHN++
Sbjct: 789  --PQKCPGKAPRGLRIVTADGKLTAEQGHNVT 818


>ref|NP_001192915.1| VPS10 domain-containing receptor SorCS3 [Bos taurus].
          Length = 1222

 Score =  207 bits (528), Expect = 3e-53
 Identities = 161/655 (24%), Positives = 315/655 (48%), Gaps = 22/655 (3%)
 Frame = +1

Query: 337  RLANNTHQHVFDDLSGSVSLSWVGDSTGIILVLTTFHVPLVIMTFGQSKLYRSEDYGKNF 516
            RL + +     D       + W G ++ +IL+LT  +    + +  +S L+RS DYG  +
Sbjct: 182  RLPSTSFALTGDSAHNQAMVHWSGHNSSVILILTKLY-DFNLGSVTESSLWRSTDYGTTY 240

Query: 517  KDITNLINNTFIRTEFGMAIGPENSGKVILTAEVSGGSHGGRIFRSSDFAKNFIQTNLPF 696
            + + + +    + +   + + P N  K++L ++    S    I  SSD    + +  L F
Sbjct: 241  EKLNDKVGLKTVLSY--LYVNPTNKRKIMLLSDPEIESS---ILISSDEGATYQKYRLTF 295

Query: 697  HPLTQMMYSPQNSDHLLALSTENGLWVSKNFGGKWEEIHKAVCLAKWGSDSTIFFTTYVN 876
            + +  +++ P+  D +LA S +  L+ S +FG +W+ +H+ +   +       F+ +   
Sbjct: 296  Y-IQSLLFHPKQEDWVLAYSLDQKLYSSMDFGRRWQLMHERITPNR-------FYWSVAG 347

Query: 877  GSCKADLGALELRRTSDLGKSFKTIGVKIYS----FGLGGRFLFASVMADKDTTRRIHVS 1044
               +ADL  +E+R T+D    + T  ++  +     G   R +  S +  +D    I V+
Sbjct: 348  LDKEADLVHMEVR-TADGYAHYLTCRIQECAETTRSGPFARSIDISSLVVQDEYIFIQVT 406

Query: 1045 TD---------QGDTWSMAQLPSVGQEQFYSILAANDDMVFMHVDEPGDTGFGTIFTSDD 1197
            T          + + ++  +LP     +   I++ N++ VF  V E        ++ SD 
Sbjct: 407  TGGRASYYVSYRREAFAQIKLPKYSLPKDMHIISTNENQVFAAVQEWNQNDTYNLYISDT 466

Query: 1198 RGIVYSKSLDRHLYTTTG--GET--DFTNVTSLRGVYMTSVLSEDNSIQTMITFDQGGRW 1365
            RGI ++ +++ ++ ++ G  G    +   V  ++G+++ +    D+ ++T IT+++G  W
Sbjct: 467  RGIYFTLAME-NIKSSRGLMGNIIIELYEVAGIKGIFLANK-KVDDQVKTYITYNKGRDW 524

Query: 1366 KHLRKPE-NSECDATAKNKNECSLHIHASYSISQKLNVPMAPLSEPNAVGIVIAHGSVGD 1542
            + L+ P+ +   +        CSLH+H   S +   +  ++  S+  A G+V+A G++G 
Sbjct: 525  RLLQAPDMDLRGNPIHCLLPFCSLHLHLQISENPYSSGRIS--SKETAPGLVVATGNIGP 582

Query: 1543 AISVMIPDVYISDDGGYSWLKMLEGPHYYTILDSGGIIVAIEHSSHPINVIKFSTDEGQC 1722
             +S     V+IS DGG +W ++ +  +    LD GG +VA++H+  P+  +  S DEG  
Sbjct: 583  ELSYTDISVFISSDGGNTWRQIFDEEYNVWFLDWGGALVAMKHTPLPVRHLWVSFDEGHS 642

Query: 1723 WQTYVFSREPIYFTGLASEPGARSMNISIWGFTESFLTRQWVSYTIDFKDILERNCEEKD 1902
            W  Y F+  P++  G   E G  +  ++++G     L  +W    +D+K I  R+C ++D
Sbjct: 643  WDKYGFTSVPLFVDGALVEAGVETQIMTVFGHFS--LRSEWQLVKVDYKSIFSRHCSKED 700

Query: 1903 YTVWLAHSTDPGDYGDGCILGYKEQYLRLRKSSVCQNGRDYVVTKQPSVCPCSLEDFLCD 2082
            Y  W  H     + G+ C++G ++ + + +  + C  GRD   T     C C+  DF CD
Sbjct: 701  YQTW--HLL---NQGEPCVMGERKIFKKRKPGAQCALGRDSSGTVVSEPCVCADWDFECD 755

Query: 2083 FGYFRPENDSKCVE----QPELKGHDLEFCLYGREEHLTTNGYRKIPGDRCQGGV 2235
            +GY R   +S+CV      P     D   C  G + +  + GYR+I  ++C  G+
Sbjct: 756  YGYER-HGESQCVPAFWYNPASPSKD---CSLG-QSYFNSTGYRRIVSNKCTDGL 805


>ref|XP_002698518.1| PREDICTED: sortilin-related VPS10 domain containing receptor 3 [Bos
            taurus].
          Length = 1222

 Score =  207 bits (528), Expect = 3e-53
 Identities = 161/655 (24%), Positives = 315/655 (48%), Gaps = 22/655 (3%)
 Frame = +1

Query: 337  RLANNTHQHVFDDLSGSVSLSWVGDSTGIILVLTTFHVPLVIMTFGQSKLYRSEDYGKNF 516
            RL + +     D       + W G ++ +IL+LT  +    + +  +S L+RS DYG  +
Sbjct: 182  RLPSTSFALTGDSAHNQAMVHWSGHNSSVILILTKLY-DFNLGSVTESSLWRSTDYGTTY 240

Query: 517  KDITNLINNTFIRTEFGMAIGPENSGKVILTAEVSGGSHGGRIFRSSDFAKNFIQTNLPF 696
            + + + +    + +   + + P N  K++L ++    S    I  SSD    + +  L F
Sbjct: 241  EKLNDKVGLKTVLSY--LYVNPTNKRKIMLLSDPEIESS---ILISSDEGATYQKYRLTF 295

Query: 697  HPLTQMMYSPQNSDHLLALSTENGLWVSKNFGGKWEEIHKAVCLAKWGSDSTIFFTTYVN 876
            + +  +++ P+  D +LA S +  L+ S +FG +W+ +H+ +   +       F+ +   
Sbjct: 296  Y-IQSLLFHPKQEDWVLAYSLDQKLYSSMDFGRRWQLMHERITPNR-------FYWSVAG 347

Query: 877  GSCKADLGALELRRTSDLGKSFKTIGVKIYS----FGLGGRFLFASVMADKDTTRRIHVS 1044
               +ADL  +E+R T+D    + T  ++  +     G   R +  S +  +D    I V+
Sbjct: 348  LDKEADLVHMEVR-TADGYAHYLTCRIQECAETTRSGPFARSIDISSLVVQDEYIFIQVT 406

Query: 1045 TD---------QGDTWSMAQLPSVGQEQFYSILAANDDMVFMHVDEPGDTGFGTIFTSDD 1197
            T          + + ++  +LP     +   I++ N++ VF  V E        ++ SD 
Sbjct: 407  TGGRASYYVSYRREAFAQIKLPKYSLPKDMHIISTNENQVFAAVQEWNQNDTYNLYISDT 466

Query: 1198 RGIVYSKSLDRHLYTTTG--GET--DFTNVTSLRGVYMTSVLSEDNSIQTMITFDQGGRW 1365
            RGI ++ +++ ++ ++ G  G    +   V  ++G+++ +    D+ ++T IT+++G  W
Sbjct: 467  RGIYFTLAME-NIKSSRGLMGNIIIELYEVAGIKGIFLANK-KVDDQVKTYITYNKGRDW 524

Query: 1366 KHLRKPE-NSECDATAKNKNECSLHIHASYSISQKLNVPMAPLSEPNAVGIVIAHGSVGD 1542
            + L+ P+ +   +        CSLH+H   S +   +  ++  S+  A G+V+A G++G 
Sbjct: 525  RLLQAPDMDLRGNPIHCLLPFCSLHLHLQISENPYSSGRIS--SKETAPGLVVATGNIGP 582

Query: 1543 AISVMIPDVYISDDGGYSWLKMLEGPHYYTILDSGGIIVAIEHSSHPINVIKFSTDEGQC 1722
             +S     V+IS DGG +W ++ +  +    LD GG +VA++H+  P+  +  S DEG  
Sbjct: 583  ELSYTDISVFISSDGGNTWRQIFDEEYNVWFLDWGGALVAMKHTPLPVRHLWVSFDEGHS 642

Query: 1723 WQTYVFSREPIYFTGLASEPGARSMNISIWGFTESFLTRQWVSYTIDFKDILERNCEEKD 1902
            W  Y F+  P++  G   E G  +  ++++G     L  +W    +D+K I  R+C ++D
Sbjct: 643  WDKYGFTSVPLFVDGALVEAGVETQIMTVFGHFS--LRSEWQLVKVDYKSIFSRHCSKED 700

Query: 1903 YTVWLAHSTDPGDYGDGCILGYKEQYLRLRKSSVCQNGRDYVVTKQPSVCPCSLEDFLCD 2082
            Y  W  H     + G+ C++G ++ + + +  + C  GRD   T     C C+  DF CD
Sbjct: 701  YQTW--HLL---NQGEPCVMGERKIFKKRKPGAQCALGRDSSGTVVSEPCVCADWDFECD 755

Query: 2083 FGYFRPENDSKCVE----QPELKGHDLEFCLYGREEHLTTNGYRKIPGDRCQGGV 2235
            +GY R   +S+CV      P     D   C  G + +  + GYR+I  ++C  G+
Sbjct: 756  YGYER-HGESQCVPAFWYNPASPSKD---CSLG-QSYFNSTGYRRIVSNKCTDGL 805


>ref|XP_002698566.1| PREDICTED: sortilin-related VPS10 domain containing receptor 1 [Bos
            taurus].
          Length = 1172

 Score =  190 bits (483), Expect = 5e-48
 Identities = 166/692 (23%), Positives = 308/692 (44%), Gaps = 26/692 (3%)
 Frame = +1

Query: 337  RLANNTHQHVFDDLSGSVSLSWVGDSTGIILVLTT-FHVPLVIMTFGQSKLYRSEDYGKN 513
            +L + T     D       + W G ++ +IL+LT  F   L  +T  +S L+RS DYG  
Sbjct: 159  KLTSTTFALTGDSAHNQAMVHWSGHNSSVILILTKLFDYNLGSIT--ESSLWRSTDYGTT 216

Query: 514  FKDITNLINNTFIRTEFGMAIGPENSGKVILTAEVSGGSHGGRIFRSSDFAKNFIQTNLP 693
            ++ + + +    I +   + + P N  K++L  +    S    +  SSD    + +  L 
Sbjct: 217  YEKLNDKVGLKTILSY--LYVCPTNKRKIMLLTDPEIESS---LLISSDEGATYQKYRLN 271

Query: 694  FHPLTQMMYSPQNSDHLLALSTENGLWVSKNFGGKWEEIHKAVCLAKWGSDSTIFFTTYV 873
            F+ +  +++ P+  D +LA S +  L+ S  FG +W+ I +AV   +       F+ + +
Sbjct: 272  FY-IQSLLFHPKQEDWILAYSQDQKLYSSAEFGRRWQLIQEAVVPNR-------FYWSVM 323

Query: 874  NGSCKADLGALELRRTSDLGKSFKTIGVKIYSFGLGGRFLFASVMADKDTTRRIHVSTD- 1050
              + + DL  LE R T D    + T  ++  +     +     +  D    +  +V    
Sbjct: 324  GSNKEPDLVHLEAR-TVDGHSQYLTCRMQNCTEANRNKPFPGYIDPDSLIVQDDYVFVQL 382

Query: 1051 ------------QGDTWSMAQLPSVGQEQFYSILAANDDMVFMHVDEPGDTGFGTIFTSD 1194
                        + + ++  +LP     +   +++ +++ VF  V E        ++ SD
Sbjct: 383  TSGGRPHYYVSYRRNAFAQMKLPKYALPKDMHVISTDENQVFAAVQEWNQNDTYNLYISD 442

Query: 1195 DRGIVYSKSLDRHLYTTTGGE----TDFTNVTSLRGVYMTSVLSEDNSIQTMITFDQGGR 1362
             RG+ ++ +L+ ++ ++ G E     D   V  ++G+++ +    DN ++T IT+++G  
Sbjct: 443  TRGVYFTLALE-NVQSSRGPEGNVMIDLYEVAGIKGMFLANK-KIDNQVKTFITYNKGRD 500

Query: 1363 WKHLRKPENS-ECDATAKNKNECSLHIHASYSISQKLNVPMAPLSEPNAVGIVIAHGSVG 1539
            W+ L+ P+     D        CSLH+H   S +   +  +A  S   A  I++A G++G
Sbjct: 501  WRLLQAPDTDLRGDPVHCVLPYCSLHLHLKVSENPYTSGIIA--SRDTAPSIIVASGNIG 558

Query: 1540 DAISVMIPDVYISDDGGYSWLKMLEGPHYYTILDSGGIIVAIEHSSHPINVIKFSTDEGQ 1719
              +S     +++S D G +W ++ E  H    LD GG++VA++H+S PI  +  S DEG+
Sbjct: 559  SELSDSDISMFVSSDAGNTWRQIFEEEHSVLYLDQGGVLVAMKHTSLPIRHLWLSFDEGR 618

Query: 1720 CWQTYVFSREPIYFTGLASEPGARSMNISIWGFTESFLTRQWVSYTIDFKDILERNCEEK 1899
             W  Y F+  P++  G+  EPG  ++ ++I  F   F  R     T+D            
Sbjct: 619  SWSKYSFTSIPLFVDGVLGEPGEETLIMTI-NFVVMFCNR-----TLD------------ 660

Query: 1900 DYTVWLAHSTDPGDYGDGCILGYKEQYLRLRKSSVCQNGRDYVVTKQPSVCPCSLEDFLC 2079
                           G+ CI+G K  Y + +    C  G+ Y    +   C C+  DF C
Sbjct: 661  ---------------GEACIMGAKRIYKKRKSERKCMQGK-YAGAMESEPCVCTEADFDC 704

Query: 2080 DFGYFRPENDSKCVEQPELKGHDL-EFCLYGREEHLTTNGYRKIPGDRCQGGVNPAREVK 2256
            D+GY R  N  +C+         L + C  G + +L + GYRK+  + C  GV      K
Sbjct: 705  DYGYERHSN-GQCLPAFWFNPSSLSKDCSLG-QSYLNSTGYRKVVSNNCTDGVREQYTAK 762

Query: 2257 DLKKKCTS------NFLSPEKQDSRPQGHNLS 2334
               +KC          ++ + + +  QGHN++
Sbjct: 763  --PQKCPGKAPRGLRIVTADGKLTAEQGHNVT 792


  Database: RefSeq49_BP.fasta
    Posted date:  Oct 17, 2011  1:42 PM
  Number of letters in database: 17,681,374
  Number of sequences in database:  33,088
  
Lambda     K      H
   0.318    0.134    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 33088
Number of Hits to DB: 107,734,458
Number of extensions: 3094293
Number of successful extensions: 9627
Number of sequences better than 1.0e-05: 8
Number of HSP's gapped: 9566
Number of HSP's successfully gapped: 15
Length of query: 909
Length of database: 17,681,374
Length adjustment: 111
Effective length of query: 798
Effective length of database: 14,008,606
Effective search space: 11178867588
Effective search space used: 11178867588
Neighboring words threshold: 12
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 36 (18.5 bits)

BLASTX 2.2.24 [Aug-08-2010]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= 20110601C-002457
         (2728 letters)

Database: RefSeq49_CP.fasta 
           33,336 sequences; 18,874,504 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

Alignment   gi|XP_537041.2| PREDICTED: similar to sortilin 1 preproprotein ...  1459   0.0  
Alignment   gi|XP_536545.2| PREDICTED: similar to sortilin-related receptor...   239   1e-62
Alignment   gi|XP_535010.2| PREDICTED: similar to SORCS receptor 1 isoform ...   217   5e-56
Alignment   gi|XP_544009.2| PREDICTED: similar to VPS10 domain receptor pro...   208   2e-53
Alignment   gi|XP_545903.2| PREDICTED: similar to VPS10 domain-containing r...   206   7e-53

>ref|XP_537041.2| PREDICTED: similar to sortilin 1 preproprotein [Canis familiaris].
          Length = 826

 Score = 1459 bits (3776), Expect = 0.0
 Identities = 716/807 (88%), Positives = 732/807 (90%)
 Frame = +1

Query: 94   HGLGXXXXXXXXLLPPASLGQDRLDXXXXXXXXLSRWSGPVGVSWGLXXXXXXXXXXXXX 273
            HGLG        LLPPASLGQDRLD        LSRW GPVGVSWGL             
Sbjct: 9    HGLGLPLLLLVQLLPPASLGQDRLDAPPPPAAPLSRWPGPVGVSWGLRAAAPGGPGLRAG 68

Query: 274  XWRRSALDEDEDCGGVRDFVARLANNTHQHVFDDLSGSVSLSWVGDSTGIILVLTTFHVP 453
             WRRSAL +D+DCG VRD VA+LANNTHQHVFDDLS SVSLSWVGD TGIILVLTTFHVP
Sbjct: 69   RWRRSALQDDQDCGRVRDVVAKLANNTHQHVFDDLSVSVSLSWVGDGTGIILVLTTFHVP 128

Query: 454  LVIMTFGQSKLYRSEDYGKNFKDITNLINNTFIRTEFGMAIGPENSGKVILTAEVSGGSH 633
            LVIMTFGQSKLYRSEDYGKNFKDITNLINNTFIRTEFGMAIGPENSGKVILTAEVSGGSH
Sbjct: 129  LVIMTFGQSKLYRSEDYGKNFKDITNLINNTFIRTEFGMAIGPENSGKVILTAEVSGGSH 188

Query: 634  GGRIFRSSDFAKNFIQTNLPFHPLTQMMYSPQNSDHLLALSTENGLWVSKNFGGKWEEIH 813
            GGRIFRSSDFAKNF+Q+NLPFHPLTQMMYSPQNSD+LLALSTENGLWVSK+FGGKWEEIH
Sbjct: 189  GGRIFRSSDFAKNFVQSNLPFHPLTQMMYSPQNSDYLLALSTENGLWVSKDFGGKWEEIH 248

Query: 814  KAVCLAKWGSDSTIFFTTYVNGSCKADLGALELRRTSDLGKSFKTIGVKIYSFGLGGRFL 993
            KAVCLAKWGS++TIFFTTY NGSCKADLGALEL RTSDLGKSFKTIGVKIYSFGLGGRFL
Sbjct: 249  KAVCLAKWGSENTIFFTTYANGSCKADLGALELWRTSDLGKSFKTIGVKIYSFGLGGRFL 308

Query: 994  FASVMADKDTTRRIHVSTDQGDTWSMAQLPSVGQEQFYSILAANDDMVFMHVDEPGDTGF 1173
            FASVMADKDTTRRIHVSTDQGDTWSMAQLPSVGQEQFYSILAANDDMVFMHVDEPGDTG+
Sbjct: 309  FASVMADKDTTRRIHVSTDQGDTWSMAQLPSVGQEQFYSILAANDDMVFMHVDEPGDTGY 368

Query: 1174 GTIFTSDDRGIVYSKSLDRHLYTTTGGETDFTNVTSLRGVYMTSVLSEDNSIQTMITFDQ 1353
            GTIFTSDDRGIVYSKSLDRHLYTTTGGETDFTNVTSLRGVY+TSVLSEDNSIQTMITFDQ
Sbjct: 369  GTIFTSDDRGIVYSKSLDRHLYTTTGGETDFTNVTSLRGVYITSVLSEDNSIQTMITFDQ 428

Query: 1354 GGRWKHLRKPENSECDATAKNKNECSLHIHASYSISQKLNVPMAPLSEPNAVGIVIAHGS 1533
            GGRWKHLRKPENSECDATAKNKNECSLHIHASYSISQKLNVPMAPLSEP AVGIVIAHGS
Sbjct: 429  GGRWKHLRKPENSECDATAKNKNECSLHIHASYSISQKLNVPMAPLSEPKAVGIVIAHGS 488

Query: 1534 VGDAISVMIPDVYISDDGGYSWLKMLEGPHYYTILDSGGIIVAIEHSSHPINVIKFSTDE 1713
            VGDAISVMIPDVYISDDGGYSW KMLEGPHYYTILDSGGIIVAIEHSSHPINVIKFSTDE
Sbjct: 489  VGDAISVMIPDVYISDDGGYSWAKMLEGPHYYTILDSGGIIVAIEHSSHPINVIKFSTDE 548

Query: 1714 GQCWQTYVFSREPIYFTGLASEPGARSMNISIWGFTESFLTRQWVSYTIDFKDILERNCE 1893
            GQCWQTY+F+REPIYFTGLASEPGARSMNISIWGFTESFLTRQWVSYTIDFKD+LERNCE
Sbjct: 549  GQCWQTYMFTREPIYFTGLASEPGARSMNISIWGFTESFLTRQWVSYTIDFKDVLERNCE 608

Query: 1894 EKDYTVWLAHSTDPGDYGDGCILGYKEQYLRLRKSSVCQNGRDYVVTKQPSVCPCSLEDF 2073
            EKDYT+WLAHS DPGDYGDGCILGYKEQYLRLRKSSVCQNGRDYVVTKQPSVCPCSLEDF
Sbjct: 609  EKDYTIWLAHSADPGDYGDGCILGYKEQYLRLRKSSVCQNGRDYVVTKQPSVCPCSLEDF 668

Query: 2074 LCDFGYFRPENDSKCVEQPELKGHDLEFCLYGREEHLTTNGYRKIPGDRCQGGVNPAREV 2253
            LCDFGYFRPENDSKCVEQPELKGHDLEFCLYGREEHLTTNGYRKIPGDRCQGGVNP REV
Sbjct: 669  LCDFGYFRPENDSKCVEQPELKGHDLEFCLYGREEHLTTNGYRKIPGDRCQGGVNPVREV 728

Query: 2254 KDLKKKCTSNFLSPEKQDSRPQGHNLSQNPAPPPLGYTENTHSLSPTQKQNSKSSSVPII 2433
            KDLKKKCTSNFLSPE                                 KQNSKS+SVPII
Sbjct: 729  KDLKKKCTSNFLSPE---------------------------------KQNSKSNSVPII 755

Query: 2434 LATVGLMLVTVVAGVLIVKKYVCGGRF 2514
            LATVGLMLVTVVAGVLIVKKYVCGGRF
Sbjct: 756  LATVGLMLVTVVAGVLIVKKYVCGGRF 782



 Score = 57.8 bits (138), Expect(2) = 4e-13
 Identities = 27/30 (90%), Positives = 28/30 (93%)
 Frame = +3

Query: 2505 GKVLVHRYSVLQQHAEANGVDGVDALDTPS 2594
            G+ LVHRYSVLQQHAEANGVDGVDALDT S
Sbjct: 780  GRFLVHRYSVLQQHAEANGVDGVDALDTAS 809



 Score = 37.0 bits (84), Expect(2) = 4e-13
 Identities = 16/18 (88%), Positives = 16/18 (88%)
 Frame = +2

Query: 2588 ALHTTKSGYHDDSDEDLL 2641
            A HT KSGYHDDSDEDLL
Sbjct: 808  ASHTHKSGYHDDSDEDLL 825


>ref|XP_536545.2| PREDICTED: similar to sortilin-related receptor containing LDLR class
            A repeats preproprotein [Canis familiaris].
          Length = 2204

 Score =  239 bits (609), Expect = 1e-62
 Identities = 193/678 (28%), Positives = 317/678 (46%), Gaps = 57/678 (8%)
 Frame = +1

Query: 370  DDLSGSVSLSWVGDSTGIILVLTTFHVPLVIMTFGQSKLYRSEDYGKNFKDITNLINNTF 549
            +D    + + W G+ + +I+ L      L +     S +Y S DYGK+FK I+  +N   
Sbjct: 89   NDSHNQMVVHWAGEKSNVIVALA--RDSLALARPRSSDVYVSYDYGKSFKRISEKLN--- 143

Query: 550  IRTEFGMAIGPENSGKVILTA----------EVSGGSHGGRIFRSSDFAKNFIQTNLPFH 699
                     G  NS + ++             +   ++   ++ + DF       ++PF 
Sbjct: 144  --------FGEGNSSEAVIAQFYHSPADNKRYIFADAYAQYLWITFDFCNTLQGFSIPFR 195

Query: 700  PLTQMMYSPQNSDHLLALSTENG---LWVSKNFGGKWEEIHKAVCLAKWGSD-----STI 855
                +++S + SD LL     +    LW S +FG  W  I + V    WG D     +TI
Sbjct: 196  AADLLLHS-KASDLLLGFDRSHPNKQLWKSDDFGQTWILIQEHVKSFSWGIDPYDKPNTI 254

Query: 856  FFTTYVNGSCKADLGALELRRTSDLGKSFKTIGV---KIYSFGLGGRFLFASVMAD---- 1014
            +   +         G   + R++D  +S +   V   ++  F L  +++FA+        
Sbjct: 255  YVERHEPS------GYSTVFRSTDFFQSLENQEVILEEVRDFQLRDKYMFATKAVHLLGG 308

Query: 1015 -KDTTRRIHVSTDQGDTWSMAQLPSVGQEQFYSILAANDDMVFMHVDEPGDTGFGTIFTS 1191
             +  + ++ VS D+      AQ  +      Y I  A++D VF+ V    +     ++ S
Sbjct: 309  LQPASVQLWVSFDR-KPMRAAQFVTRHPINEYYIADASEDQVFVCVSHSNNRT--NLYIS 365

Query: 1192 DDRGIVYSKSLDRHLYTTTGGE--------------TDFTNVTSLRGVYMTSVLS---ED 1320
            +  G+ +S SL+  LY + GG                DF  V  L+GVY+ ++++    +
Sbjct: 366  EAEGLKFSLSLENVLYYSPGGAGGDTLVRYFANEPFADFHRVEGLQGVYIATLINGSMNE 425

Query: 1321 NSIQTMITFDQGGRWKHLRKP------ENSECDATAKNKNECSLHIHASYSISQKLNVP- 1479
             +++++ITFD+GG W+ L+ P      E   C+ +      CSLH+  +  +SQ LN+  
Sbjct: 426  ENMRSVITFDKGGTWEFLQAPAFTGYGEKINCELS----QGCSLHL--AQRLSQLLNLQL 479

Query: 1480 --MAPLSEPNAVGIVIAHGSVGDAISVMIPDVYISDDGGYSWLKMLEGPHYYTILDSGGI 1653
              M  LS+ +A G++IA GSVG  ++    +VYIS   G  W + L GPHYYT  D GGI
Sbjct: 480  RRMPILSKESAPGLIIATGSVGKNLASKT-NVYISSSAGARWREALPGPHYYTWGDHGGI 538

Query: 1654 IVAIEHSSHPINVIKFSTDEGQCWQTYVFSREPIYFTGLASEPGARSMNISIWGFTESFL 1833
            I+AI       N +K+ST+EG+ W+T++FS  P++  GL +EPG +S   +I+G  +  +
Sbjct: 539  IMAIAQGMET-NELKYSTNEGETWKTFIFSERPVFVYGLLTEPGEKSTVFTIFGSNKENV 597

Query: 1834 TRQWVSYTIDFKDILERNCEEKDYTVWLAHSTDPGDYGDGCILGYKEQYLRLRKSSVCQN 2013
               W+   ++  D L   C E DY +W    +   + G+ C+LG+K  + R    + C N
Sbjct: 598  -HNWLILQVNATDALGVPCTENDYKLW----SPSDERGNECLLGHKTVFKRRTPHATCFN 652

Query: 2014 GRDYVVTKQPSVCPCSLEDFLCDFGYFRPEND--SKCVEQPELKGHDLE---FCLYGREE 2178
            G D+      S C C+ +D+ CDFG+   E+     CV  PE  G        C  G   
Sbjct: 653  GEDFDRPVVVSNCSCTRQDYECDFGFKMSEDFFLEVCVPDPEFSGKSYAPPMPCPVG-ST 711

Query: 2179 HLTTNGYRKIPGDRCQGG 2232
            +  T GYRKI GD C GG
Sbjct: 712  YRRTRGYRKISGDTCSGG 729


>ref|XP_535010.2| PREDICTED: similar to SORCS receptor 1 isoform a [Canis familiaris].
          Length = 997

 Score =  217 bits (552), Expect = 5e-56
 Identities = 166/671 (24%), Positives = 312/671 (46%), Gaps = 34/671 (5%)
 Frame = +1

Query: 424  ILVLTTFHVPLVIMT---------FGQSKLYRSEDYGKNFKDITNLINNTFIRTEFGMAI 576
            I+VL ++H  ++I+T           +S L+RS DYG  ++ + + +    I +   + +
Sbjct: 7    IMVLRSWHSVILILTKLYDYNLGSITESSLWRSTDYGTTYEKLNDKVGLKTILSY--LYV 64

Query: 577  GPENSGKVILTAEVSGGSHGGRIFRSSDFAKNFIQTNLPFHPLTQMMYSPQNSDHLLALS 756
             P N  K++L  +    S    +  SSD    + +  L F+ +  +++ P+  D +LA S
Sbjct: 65   CPTNKRKIMLLTDPEIESS---LLISSDEGATYQKYRLNFY-IQSLLFHPKQEDWILAYS 120

Query: 757  TENGLWVSKNFGGKWEEIHKAVCLAKWGSDSTIFFTTYVNGSCKADLGALELRRTSDLGK 936
             +  L+ S  FG +W+ I + V   +       F+ + +  + + DL  LE R T D   
Sbjct: 121  QDQKLYSSAEFGRRWQLIQEGVVPNR-------FYWSVMGSNKEPDLVHLEAR-TVDGHS 172

Query: 937  SFKTIGVKIYSFGLGGRFLFASVMADKDTTRRIHVSTD-------------QGDTWSMAQ 1077
             + T  ++  +     +     +  D    +  +V                + + ++  +
Sbjct: 173  QYLTCRMQNCTEANRNKPFPGYIDPDSLIVQDDYVFVQLTSGGRPHYYVSYRRNAFAQMK 232

Query: 1078 LPSVGQEQFYSILAANDDMVFMHVDEPGDTGFGTIFTSDDRGIVYSKSLDRHLYTTTGGE 1257
            LP     +   +++ +++ VF  V E        ++ SD RG+ ++ +L+ ++ ++ G E
Sbjct: 233  LPKYALPKDMHVISTDENQVFAAVQEWNQNDTYNLYISDTRGVYFTLALE-NVQSSRGPE 291

Query: 1258 ----TDFTNVTSLRGVYMTSVLSEDNSIQTMITFDQGGRWKHLRKPENS-ECDATAKNKN 1422
                 D   V  ++G+++ +    DN ++T IT+++G  W+ L+ P+     D       
Sbjct: 292  GNIMIDLYEVAGIKGMFLANK-KIDNQVKTFITYNKGRDWRLLQAPDTDLRGDPVHCLLP 350

Query: 1423 ECSLHIHASYSISQKLNVPMAPLSEPNAVGIVIAHGSVGDAISVMIPDVYISDDGGYSWL 1602
             CSLH+H   S +   +  +A  S   A  I++A G++G  +S     +++S D G +W 
Sbjct: 351  YCSLHLHLKVSENPYTSGIIA--SRDTAPSIIVASGNIGSELSDSDISMFVSSDAGNTWR 408

Query: 1603 KMLEGPHYYTILDSGGIIVAIEHSSHPINVIKFSTDEGQCWQTYVFSREPIYFTGLASEP 1782
            ++ E  H    LD GG++VA++H+S PI  +  S DEG+ W  Y F+  P++  G+  EP
Sbjct: 409  QIFEEEHSVLYLDQGGVLVAMKHTSLPIRHLWLSFDEGRSWSKYSFTSIPLFVDGVLGEP 468

Query: 1783 GARSMNISIWGFTESFLTRQWVSYTIDFKDILERNCEEKDYTVWLAHSTDPGDYGDGCIL 1962
            G  ++ ++++G        +W    +D+K I +R C E+DY  W  HS      G+ CI+
Sbjct: 469  GEETLIMTVFGHFSH--RSEWQLVKVDYKSIFDRRCAEEDYRPWQLHS-----QGEACIM 521

Query: 1963 GYKEQYLRLRKSSVCQNGRDYVVTKQPSVCPCSLEDFLCDFGYFRPENDSKCVEQPELKG 2142
            G K  Y + +    C  G+ Y    +   C C+  DF CD+GY R  N  +C+       
Sbjct: 522  GAKRIYKKRKSERKCMQGK-YAGAMESEPCVCTEADFDCDYGYERHSN-GQCLPAFWFNP 579

Query: 2143 HDL-EFCLYGREEHLTTNGYRKIPGDRCQGGVNPAREVKDLKKKCTS------NFLSPEK 2301
              L + C  G + +L + GYRK+  + C  GV      K   +KC          ++ + 
Sbjct: 580  SSLSKDCSLG-QSYLNSTGYRKVVSNNCTDGVREQYTAK--PQKCPGKAPRGLRIVTADG 636

Query: 2302 QDSRPQGHNLS 2334
            + +  QGHN++
Sbjct: 637  KLTAEQGHNVT 647


>ref|XP_544009.2| PREDICTED: similar to VPS10 domain receptor protein SORCS 3 [Canis
            familiaris].
          Length = 1135

 Score =  208 bits (530), Expect = 2e-53
 Identities = 164/663 (24%), Positives = 316/663 (47%), Gaps = 22/663 (3%)
 Frame = +1

Query: 313  GGVRDFVARLANNTHQHVFDDLSGSVSLSWVGDSTGIILVLTTFHVPLVIMTFGQSKLYR 492
            GG      RL + +     D       + W G ++ +IL+LT  +    + +  +S L+R
Sbjct: 87   GGAAAEELRLPSTSFALTGDSAHNQAMVHWSGHNSSVILILTKLY-DFNLGSVTESSLWR 145

Query: 493  SEDYGKNFKDITNLINNTFIRTEFGMAIGPENSGKVILTAEVSGGSHGGRIFRSSDFAKN 672
            S DYG  ++ + + +    + +   + + P N  K++L ++    S    I  SSD    
Sbjct: 146  STDYGTTYEKLNDKVGLKTVLSY--LYVNPTNKRKIMLLSDPEMESS---ILISSDEGAT 200

Query: 673  FIQTNLPFHPLTQMMYSPQNSDHLLALSTENGLWVSKNFGGKWEEIHKAVCLAKWGSDST 852
            + +  L F+ +  +++ P+  D +LA S +  L+ S +FG +W+ +H+ +   +      
Sbjct: 201  YQKYRLTFY-IQSLLFHPRQEDWVLAYSLDQKLYSSMDFGRRWQLMHERITPNR------ 253

Query: 853  IFFTTYVNGSCKADLGALELRRTSDLGKSFKTIGVKIYS----FGLGGRFLFASVMADKD 1020
             F+ +      +ADL  +E+R T+D    + T  ++  +     G   R +  S +  +D
Sbjct: 254  -FYWSVAGLDKEADLVHMEVR-TADGYAHYLTCRIQECAETTRSGPFARSIDISSLVVQD 311

Query: 1021 TTRRIHVSTD---------QGDTWSMAQLPSVGQEQFYSILAANDDMVFMHVDEPGDTGF 1173
                I V+T          + + ++  +LP     +   I++ +++ VF  V E      
Sbjct: 312  EYIFIQVTTGGRASYYVSYRREAFAQIKLPKYSLPKDMHIISTDENQVFAAVQEWNQNDT 371

Query: 1174 GTIFTSDDRGIVYSKSLDRHLYTTTG--GET--DFTNVTSLRGVYMTSVLSEDNSIQTMI 1341
              ++ SD RGI ++ +++ ++ ++ G  G    +   V  +RG+++ +    D+ ++T I
Sbjct: 372  YNLYISDTRGIYFTLAME-NIKSSRGLMGNIIIELYEVAGIRGIFLANK-KVDDQVKTYI 429

Query: 1342 TFDQGGRWKHLRKPENSECDATAKNKNE-CSLHIHASYSISQKLNVPMAPLSEPNAVGIV 1518
            T+++G  W+ L+ P+     +        CSLH+H   S +   +  ++  S+  A G+V
Sbjct: 430  TYNKGRDWRLLQAPDVDLRGSPVHCLLPFCSLHLHLQISENPYSSGRIS--SKETAPGLV 487

Query: 1519 IAHGSVGDAISVMIPDVYISDDGGYSWLKMLEGPHYYTILDSGGIIVAIEHSSHPINVIK 1698
            +A G++G  +S     V+IS DGG +W ++ +  +    LD GG +VA++H+  P+  + 
Sbjct: 488  VATGNIGPELSYTDIGVFISSDGGNTWRQIFDEEYNVWFLDWGGALVAMKHTPLPVRHLW 547

Query: 1699 FSTDEGQCWQTYVFSREPIYFTGLASEPGARSMNISIWGFTESFLTRQWVSYTIDFKDIL 1878
             S DEG  W  Y F+  P++  G   E G  +  ++++G     L  +W    +D+K I 
Sbjct: 548  VSFDEGHSWDKYGFTSVPLFVDGALVEAGVETQIMTVFGHFS--LRSEWQLVKVDYKSIF 605

Query: 1879 ERNCEEKDYTVWLAHSTDPGDYGDGCILGYKEQYLRLRKSSVCQNGRDYVVTKQPSVCPC 2058
             R+C ++DY  W  H     + G+ C++G ++ + + +  + C  GRD   T     C C
Sbjct: 606  SRHCTKEDYQTW--HLL---NQGEPCVMGERKIFKKRKPGAQCALGRDSSGTVVSEPCVC 660

Query: 2059 SLEDFLCDFGYFRPENDSKCVE----QPELKGHDLEFCLYGREEHLTTNGYRKIPGDRCQ 2226
            +  DF CD+GY R   +S+CV      P     D   C  G + +L + GYR+I  + C 
Sbjct: 661  ADWDFECDYGYER-HGESQCVPAFWYNPASPSKD---CSLG-QSYLNSTGYRRIVSNNCT 715

Query: 2227 GGV 2235
             G+
Sbjct: 716  DGL 718


>ref|XP_545903.2| PREDICTED: similar to VPS10 domain-containing receptor SorCS2
            precursor [Canis familiaris].
          Length = 1051

 Score =  206 bits (525), Expect = 7e-53
 Identities = 153/572 (26%), Positives = 273/572 (47%), Gaps = 31/572 (5%)
 Frame = +1

Query: 643  IFRSSDFAKNFIQTNLPFHPLTQMMYSPQNSDHLLALSTENGLWVSKNFGGKWEEIHKAV 822
            +F S+D    F +  +PF   T +++ P+  D +LA + EN L+VS + G KW  + + V
Sbjct: 123  LFLSTDEGATFQKQLIPFSVET-LIFHPKEEDKVLAYTKENKLYVSSDLGKKWTLLQERV 181

Query: 823  CLAKWGSDSTIFFTTYVNGSCKADLGALELRRTSDLGKSFKTIGVKIYSFG-------LG 981
                   D   +  + V+     DL  +E +   D+   F+ +  +I++           
Sbjct: 182  T-----KDHMFWSVSGVDAD--PDLVHMEAQ---DVRGGFRYVTCQIHNCSEKTLTAPFP 231

Query: 982  GRFLFASVMADKDTTRRIHVSTDQG--------DTWSMAQLPSVGQEQFYSILAANDDMV 1137
            G     S+    D       ST+Q           + + +LP     +   I++ +++ V
Sbjct: 232  GPIDHGSLTVQDDYIFFKATSTNQTKYYISYRRSEFVLMKLPKYALPKDLQIISTDENQV 291

Query: 1138 FMHVDEPGDTGFGTIFTSDDRGIVYSKSLDRHLYTTTGGET---DFTNVTSLRGVYMTSV 1308
            F+ V E        ++ SD RG+ YS  L+    +    E+   D   V  ++GV++ + 
Sbjct: 292  FVAVQEWYQMDTYNLYQSDPRGVRYSLVLEDVRSSRQAEESVVIDILEVRGVKGVFLANQ 351

Query: 1309 LSEDNSIQTMITFDQGGRWKHLRKPENSECDATAKNKN----ECSLHIHASYSISQKLNV 1476
             + +  + T+IT+++G  W HLR P     D   K  N    +C LH+H  ++ +  ++ 
Sbjct: 352  KT-NGKVVTLITYNKGRDWDHLRPPST---DMNGKPTNCEPPDCHLHLHLRWADNPYVSG 407

Query: 1477 PMAPLSEPNAVGIVIAHGSVGDAISVMIPDVYISDDGGYSWLKMLEGPHYYTILDSGGII 1656
             +   ++  A G+++  G++G  +     ++YI+ D G++W ++ E  H+   LD GG+I
Sbjct: 408  TVH--TKDTAPGLIMGAGNLGSQLVEYKEEMYITSDCGHTWRQVFEEEHHVLYLDHGGVI 465

Query: 1657 VAIEHSSHPINVIKFSTDEGQCWQTYVFSREPIYFTGLASEPGARSMNISIWGFTESFLT 1836
             AI+ +S P+ ++KFS DEG  W T+ F+   ++  GL SEPG  ++ ++++G       
Sbjct: 466  AAIKDTSIPLKILKFSVDEGLTWSTHNFTSTSVFVDGLLSEPGDETLVMTVFGHIS--FR 523

Query: 1837 RQWVSYTIDFKDILERNCEEKDYTVWLAHSTDPGDY-GDGCILGYKEQYLRLRKSSVCQN 2013
              W    +DF+    R C E DY  W     D  D  GD CI+G +  + + + +S C  
Sbjct: 524  SDWELVKVDFRPSFSRQCSEDDYGSW-----DLTDLKGDRCIMGQQRSFRKRKSTSWCIK 578

Query: 2014 GRDYVVTKQPSVCPCSLEDFLCDFGYFR-PENDS---KCVE----QPELKGHDLEFCLYG 2169
            GR +    +  VC C   DFLCD+G+ R P ++S   KC       P     D   C+ G
Sbjct: 579  GRSFTSALESRVCRCRESDFLCDYGFERSPSSESDANKCFANFWFNPLSPPDD---CVLG 635

Query: 2170 REEHLTTNGYRKIPGDRCQGGVNPAREVKDLK 2265
             + + ++ GYRK+  + C+GGV+P +    L+
Sbjct: 636  -QTYTSSLGYRKVVSNVCEGGVDPRQSPAQLQ 666


  Database: RefSeq49_CP.fasta
    Posted date:  Oct 17, 2011  1:42 PM
  Number of letters in database: 18,874,504
  Number of sequences in database:  33,336
  
Lambda     K      H
   0.318    0.134    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 33336
Number of Hits to DB: 112,467,941
Number of extensions: 3160173
Number of successful extensions: 10583
Number of sequences better than 1.0e-05: 5
Number of HSP's gapped: 10544
Number of HSP's successfully gapped: 8
Length of query: 909
Length of database: 18,874,504
Length adjustment: 112
Effective length of query: 797
Effective length of database: 15,140,872
Effective search space: 12067274984
Effective search space used: 12067274984
Neighboring words threshold: 12
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 36 (18.5 bits)

BLASTX 2.2.24 [Aug-08-2010]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= 20110601C-002457
         (2728 letters)

Database: RefSeq49_HP.fasta 
           32,964 sequences; 18,297,164 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

Alignment   gi|NP_002950.3| sortilin isoform 1 preproprotein [Homo sapiens].    1449   0.0  
Alignment   gi|NP_001192157.1| sortilin isoform 2 [Homo sapiens].               1266   0.0  
Alignment   gi|NP_003096.1| sortilin-related receptor preproprotein [Homo s...   240   4e-63
Alignment   gi|NP_065828.2| VPS10 domain-containing receptor SorCS2 precurs...   228   3e-59
Alignment   gi|NP_001193501.1| VPS10 domain-containing receptor SorCS1 isof...   225   2e-58
Alignment   gi|NP_001193500.1| VPS10 domain-containing receptor SorCS1 isof...   225   2e-58
Alignment   gi|NP_001193499.1| VPS10 domain-containing receptor SorCS1 isof...   225   2e-58
Alignment   gi|NP_001193498.1| VPS10 domain-containing receptor SorCS1 isof...   225   2e-58
Alignment   gi|NP_443150.3| VPS10 domain-containing receptor SorCS1 isoform...   225   2e-58
Alignment   gi|NP_001013049.1| VPS10 domain-containing receptor SorCS1 isof...   225   2e-58

>ref|NP_002950.3| sortilin isoform 1 preproprotein [Homo sapiens].
          Length = 831

 Score = 1449 bits (3752), Expect = 0.0
 Identities = 712/817 (87%), Positives = 734/817 (89%)
 Frame = +1

Query: 64   GAAQGLSRWPHGLGXXXXXXXXLLPPASLGQDRLDXXXXXXXXLSRWSGPVGVSWGLXXX 243
            GAA GLSRWPHGLG        LLPP++L QDRLD        L RWSGP+GVSWGL   
Sbjct: 6    GAADGLSRWPHGLGLLLLLQ--LLPPSTLSQDRLDAPPPPAAPLPRWSGPIGVSWGLRAA 63

Query: 244  XXXXXXXXXXXWRRSALDEDEDCGGVRDFVARLANNTHQHVFDDLSGSVSLSWVGDSTGI 423
                       WRRSA  EDE+CG VRDFVA+LANNTHQHVFDDL GSVSLSWVGDSTG+
Sbjct: 64   AAGGAFPRGGRWRRSAPGEDEECGRVRDFVAKLANNTHQHVFDDLRGSVSLSWVGDSTGV 123

Query: 424  ILVLTTFHVPLVIMTFGQSKLYRSEDYGKNFKDITNLINNTFIRTEFGMAIGPENSGKVI 603
            ILVLTTFHVPLVIMTFGQSKLYRSEDYGKNFKDIT+LINNTFIRTEFGMAIGPENSGKV+
Sbjct: 124  ILVLTTFHVPLVIMTFGQSKLYRSEDYGKNFKDITDLINNTFIRTEFGMAIGPENSGKVV 183

Query: 604  LTAEVSGGSHGGRIFRSSDFAKNFIQTNLPFHPLTQMMYSPQNSDHLLALSTENGLWVSK 783
            LTAEVSGGS GGRIFRSSDFAKNF+QT+LPFHPLTQMMYSPQNSD+LLALSTENGLWVSK
Sbjct: 184  LTAEVSGGSRGGRIFRSSDFAKNFVQTDLPFHPLTQMMYSPQNSDYLLALSTENGLWVSK 243

Query: 784  NFGGKWEEIHKAVCLAKWGSDSTIFFTTYVNGSCKADLGALELRRTSDLGKSFKTIGVKI 963
            NFGGKWEEIHKAVCLAKWGSD+TIFFTTY NGSCKADLGALEL RTSDLGKSFKTIGVKI
Sbjct: 244  NFGGKWEEIHKAVCLAKWGSDNTIFFTTYANGSCKADLGALELWRTSDLGKSFKTIGVKI 303

Query: 964  YSFGLGGRFLFASVMADKDTTRRIHVSTDQGDTWSMAQLPSVGQEQFYSILAANDDMVFM 1143
            YSFGLGGRFLFASVMADKDTTRRIHVSTDQGDTWSMAQLPSVGQEQFYSILAANDDMVFM
Sbjct: 304  YSFGLGGRFLFASVMADKDTTRRIHVSTDQGDTWSMAQLPSVGQEQFYSILAANDDMVFM 363

Query: 1144 HVDEPGDTGFGTIFTSDDRGIVYSKSLDRHLYTTTGGETDFTNVTSLRGVYMTSVLSEDN 1323
            HVDEPGDTGFGTIFTSDDRGIVYSKSLDRHLYTTTGGETDFTNVTSLRGVY+TSVLSEDN
Sbjct: 364  HVDEPGDTGFGTIFTSDDRGIVYSKSLDRHLYTTTGGETDFTNVTSLRGVYITSVLSEDN 423

Query: 1324 SIQTMITFDQGGRWKHLRKPENSECDATAKNKNECSLHIHASYSISQKLNVPMAPLSEPN 1503
            SIQTMITFDQGGRW HLRKPENSECDATAKNKNECSLHIHASYSISQKLNVPMAPLSEPN
Sbjct: 424  SIQTMITFDQGGRWTHLRKPENSECDATAKNKNECSLHIHASYSISQKLNVPMAPLSEPN 483

Query: 1504 AVGIVIAHGSVGDAISVMIPDVYISDDGGYSWLKMLEGPHYYTILDSGGIIVAIEHSSHP 1683
            AVGIVIAHGSVGDAISVM+PDVYISDDGGYSW KMLEGPHYYTILDSGGIIVAIEHSS P
Sbjct: 484  AVGIVIAHGSVGDAISVMVPDVYISDDGGYSWTKMLEGPHYYTILDSGGIIVAIEHSSRP 543

Query: 1684 INVIKFSTDEGQCWQTYVFSREPIYFTGLASEPGARSMNISIWGFTESFLTRQWVSYTID 1863
            INVIKFSTDEGQCWQTY F+R+PIYFTGLASEPGARSMNISIWGFTESFLT QWVSYTID
Sbjct: 544  INVIKFSTDEGQCWQTYTFTRDPIYFTGLASEPGARSMNISIWGFTESFLTSQWVSYTID 603

Query: 1864 FKDILERNCEEKDYTVWLAHSTDPGDYGDGCILGYKEQYLRLRKSSVCQNGRDYVVTKQP 2043
            FKDILERNCEEKDYT+WLAHSTDP DY DGCILGYKEQ+LRLRKSSVCQNGRDYVVTKQP
Sbjct: 604  FKDILERNCEEKDYTIWLAHSTDPEDYEDGCILGYKEQFLRLRKSSVCQNGRDYVVTKQP 663

Query: 2044 SVCPCSLEDFLCDFGYFRPENDSKCVEQPELKGHDLEFCLYGREEHLTTNGYRKIPGDRC 2223
            S+C CSLEDFLCDFGY+RPENDSKCVEQPELKGHDLEFCLYGREEHLTTNGYRKIPGD+C
Sbjct: 664  SICLCSLEDFLCDFGYYRPENDSKCVEQPELKGHDLEFCLYGREEHLTTNGYRKIPGDKC 723

Query: 2224 QGGVNPAREVKDLKKKCTSNFLSPEKQDSRPQGHNLSQNPAPPPLGYTENTHSLSPTQKQ 2403
            QGGVNP REVKDLKKKCTSNFLSPE                                 KQ
Sbjct: 724  QGGVNPVREVKDLKKKCTSNFLSPE---------------------------------KQ 750

Query: 2404 NSKSSSVPIILATVGLMLVTVVAGVLIVKKYVCGGRF 2514
            NSKS+SVPIILA VGLMLVTVVAGVLIVKKYVCGGRF
Sbjct: 751  NSKSNSVPIILAIVGLMLVTVVAGVLIVKKYVCGGRF 787



 Score = 57.8 bits (138), Expect(2) = 3e-13
 Identities = 27/30 (90%), Positives = 28/30 (93%)
 Frame = +3

Query: 2505 GKVLVHRYSVLQQHAEANGVDGVDALDTPS 2594
            G+ LVHRYSVLQQHAEANGVDGVDALDT S
Sbjct: 785  GRFLVHRYSVLQQHAEANGVDGVDALDTAS 814



 Score = 37.7 bits (86), Expect(2) = 3e-13
 Identities = 16/18 (88%), Positives = 16/18 (88%)
 Frame = +2

Query: 2588 ALHTTKSGYHDDSDEDLL 2641
            A HT KSGYHDDSDEDLL
Sbjct: 813  ASHTNKSGYHDDSDEDLL 830


>ref|NP_001192157.1| sortilin isoform 2 [Homo sapiens].
          Length = 694

 Score = 1266 bits (3277), Expect = 0.0
 Identities = 620/684 (90%), Positives = 636/684 (92%)
 Frame = +1

Query: 463  MTFGQSKLYRSEDYGKNFKDITNLINNTFIRTEFGMAIGPENSGKVILTAEVSGGSHGGR 642
            MTFGQSKLYRSEDYGKNFKDIT+LINNTFIRTEFGMAIGPENSGKV+LTAEVSGGS GGR
Sbjct: 1    MTFGQSKLYRSEDYGKNFKDITDLINNTFIRTEFGMAIGPENSGKVVLTAEVSGGSRGGR 60

Query: 643  IFRSSDFAKNFIQTNLPFHPLTQMMYSPQNSDHLLALSTENGLWVSKNFGGKWEEIHKAV 822
            IFRSSDFAKNF+QT+LPFHPLTQMMYSPQNSD+LLALSTENGLWVSKNFGGKWEEIHKAV
Sbjct: 61   IFRSSDFAKNFVQTDLPFHPLTQMMYSPQNSDYLLALSTENGLWVSKNFGGKWEEIHKAV 120

Query: 823  CLAKWGSDSTIFFTTYVNGSCKADLGALELRRTSDLGKSFKTIGVKIYSFGLGGRFLFAS 1002
            CLAKWGSD+TIFFTTY NGSC  DLGALEL RTSDLGKSFKTIGVKIYSFGLGGRFLFAS
Sbjct: 121  CLAKWGSDNTIFFTTYANGSC-TDLGALELWRTSDLGKSFKTIGVKIYSFGLGGRFLFAS 179

Query: 1003 VMADKDTTRRIHVSTDQGDTWSMAQLPSVGQEQFYSILAANDDMVFMHVDEPGDTGFGTI 1182
            VMADKDTTRRIHVSTDQGDTWSMAQLPSVGQEQFYSILAANDDMVFMHVDEPGDTGFGTI
Sbjct: 180  VMADKDTTRRIHVSTDQGDTWSMAQLPSVGQEQFYSILAANDDMVFMHVDEPGDTGFGTI 239

Query: 1183 FTSDDRGIVYSKSLDRHLYTTTGGETDFTNVTSLRGVYMTSVLSEDNSIQTMITFDQGGR 1362
            FTSDDRGIVYSKSLDRHLYTTTGGETDFTNVTSLRGVY+TSVLSEDNSIQTMITFDQGGR
Sbjct: 240  FTSDDRGIVYSKSLDRHLYTTTGGETDFTNVTSLRGVYITSVLSEDNSIQTMITFDQGGR 299

Query: 1363 WKHLRKPENSECDATAKNKNECSLHIHASYSISQKLNVPMAPLSEPNAVGIVIAHGSVGD 1542
            W HLRKPENSECDATAKNKNECSLHIHASYSISQKLNVPMAPLSEPNAVGIVIAHGSVGD
Sbjct: 300  WTHLRKPENSECDATAKNKNECSLHIHASYSISQKLNVPMAPLSEPNAVGIVIAHGSVGD 359

Query: 1543 AISVMIPDVYISDDGGYSWLKMLEGPHYYTILDSGGIIVAIEHSSHPINVIKFSTDEGQC 1722
            AISVM+PDVYISDDGGYSW KMLEGPHYYTILDSGGIIVAIEHSS PINVIKFSTDEGQC
Sbjct: 360  AISVMVPDVYISDDGGYSWTKMLEGPHYYTILDSGGIIVAIEHSSRPINVIKFSTDEGQC 419

Query: 1723 WQTYVFSREPIYFTGLASEPGARSMNISIWGFTESFLTRQWVSYTIDFKDILERNCEEKD 1902
            WQTY F+R+PIYFTGLASEPGARSMNISIWGFTESFLT QWVSYTIDFKDILERNCEEKD
Sbjct: 420  WQTYTFTRDPIYFTGLASEPGARSMNISIWGFTESFLTSQWVSYTIDFKDILERNCEEKD 479

Query: 1903 YTVWLAHSTDPGDYGDGCILGYKEQYLRLRKSSVCQNGRDYVVTKQPSVCPCSLEDFLCD 2082
            YT+WLAHSTDP DY DGCILGYKEQ+LRLRKSSVCQNGRDYVVTKQPS+C CSLEDFLCD
Sbjct: 480  YTIWLAHSTDPEDYEDGCILGYKEQFLRLRKSSVCQNGRDYVVTKQPSICLCSLEDFLCD 539

Query: 2083 FGYFRPENDSKCVEQPELKGHDLEFCLYGREEHLTTNGYRKIPGDRCQGGVNPAREVKDL 2262
            FGY+RPENDSKCVEQPELKGHDLEFCLYGREEHLTTNGYRKIPGD+CQGGVNP REVKDL
Sbjct: 540  FGYYRPENDSKCVEQPELKGHDLEFCLYGREEHLTTNGYRKIPGDKCQGGVNPVREVKDL 599

Query: 2263 KKKCTSNFLSPEKQDSRPQGHNLSQNPAPPPLGYTENTHSLSPTQKQNSKSSSVPIILAT 2442
            KKKCTSNFLSPE                                 KQNSKS+SVPIILA 
Sbjct: 600  KKKCTSNFLSPE---------------------------------KQNSKSNSVPIILAI 626

Query: 2443 VGLMLVTVVAGVLIVKKYVCGGRF 2514
            VGLMLVTVVAGVLIVKKYVCGGRF
Sbjct: 627  VGLMLVTVVAGVLIVKKYVCGGRF 650



 Score = 57.8 bits (138), Expect(2) = 3e-13
 Identities = 27/30 (90%), Positives = 28/30 (93%)
 Frame = +3

Query: 2505 GKVLVHRYSVLQQHAEANGVDGVDALDTPS 2594
            G+ LVHRYSVLQQHAEANGVDGVDALDT S
Sbjct: 648  GRFLVHRYSVLQQHAEANGVDGVDALDTAS 677



 Score = 37.7 bits (86), Expect(2) = 3e-13
 Identities = 16/18 (88%), Positives = 16/18 (88%)
 Frame = +2

Query: 2588 ALHTTKSGYHDDSDEDLL 2641
            A HT KSGYHDDSDEDLL
Sbjct: 676  ASHTNKSGYHDDSDEDLL 693


>ref|NP_003096.1| sortilin-related receptor preproprotein [Homo sapiens].
          Length = 2214

 Score =  240 bits (613), Expect = 4e-63
 Identities = 200/682 (29%), Positives = 323/682 (47%), Gaps = 56/682 (8%)
 Frame = +1

Query: 370  DDLSGSVSLSWVGDSTGIILVLTTFHVPLVIMTFGQSKLYRSEDYGKNFKDITNLINNTF 549
            +D    + + W G+ + +I+ L      L +     S +Y S DYGK+FK I++ +N   
Sbjct: 99   NDSHNQMVVHWAGEKSNVIVALA--RDSLALARPKSSDVYVSYDYGKSFKKISDKLN--- 153

Query: 550  IRTEFGMAIGPENSGKVILTAEVSGGSHGGRIFRSS---------DFAKNFIQTNLPFHP 702
                FG+      S  VI     S   +   IF  +         DF       ++PF  
Sbjct: 154  ----FGLG---NRSEAVIAQFYHSPADNKRYIFADAYAQYLWITFDFCNTLQGFSIPFRA 206

Query: 703  LTQMMYSPQNSDHLLALSTENG---LWVSKNFGGKWEEIHKAVCLAKWGSD-----STIF 858
               +++S + S+ LL     +    LW S +FG  W  I + V    WG D     +TI+
Sbjct: 207  ADLLLHS-KASNLLLGFDRSHPNKQLWKSDDFGQTWIMIQEHVKSFSWGIDPYDKPNTIY 265

Query: 859  FTTYVNGSCKADLGALELRRTSDLGKSFKTIGV---KIYSFGLGGRFLFASVM-----AD 1014
               +         G   + R++D  +S +   V   ++  F L  +++FA+ +     ++
Sbjct: 266  IERHEPS------GYSTVFRSTDFFQSRENQEVILEEVRDFQLRDKYMFATKVVHLLGSE 319

Query: 1015 KDTTRRIHVSTDQGDTWSMAQLPSVGQEQFYSILAANDDMVFMHVDEPGDTGFGTIFTSD 1194
            + ++ ++ VS  +      AQ  +      Y I  A++D VF+ V    +     ++ S+
Sbjct: 320  QQSSVQLWVSFGR-KPMRAAQFVTRHPINEYYIADASEDQVFVCVSHSNNRT--NLYISE 376

Query: 1195 DRGIVYSKSLDRHLYTTTGGE--------------TDFTNVTSLRGVYMTSVLS---EDN 1323
              G+ +S SL+  LY + GG                DF  V  L+GVY+ ++++    + 
Sbjct: 377  AEGLKFSLSLENVLYYSPGGAGSDTLVRYFANEPFADFHRVEGLQGVYIATLINGSMNEE 436

Query: 1324 SIQTMITFDQGGRWKHLRKP------ENSECDATAKNKNECSLHIHASYSISQKLNVP-- 1479
            +++++ITFD+GG W+ L+ P      E   C+ +      CSLH+  +  +SQ LN+   
Sbjct: 437  NMRSVITFDKGGTWEFLQAPAFTGYGEKINCELS----QGCSLHL--AQRLSQLLNLQLR 490

Query: 1480 -MAPLSEPNAVGIVIAHGSVGDAISVMIPDVYISDDGGYSWLKMLEGPHYYTILDSGGII 1656
             M  LS+ +A G++IA GSVG  ++    +VYIS   G  W + L GPHYYT  D GGII
Sbjct: 491  RMPILSKESAPGLIIATGSVGKNLASKT-NVYISSSAGARWREALPGPHYYTWGDHGGII 549

Query: 1657 VAIEHSSHPINVIKFSTDEGQCWQTYVFSREPIYFTGLASEPGARSMNISIWGFTESFLT 1836
             AI       N +K+ST+EG+ W+T++FS +P++  GL +EPG +S   +I+G  +  + 
Sbjct: 550  TAIAQGMET-NELKYSTNEGETWKTFIFSEKPVFVYGLLTEPGEKSTVFTIFGSNKENV- 607

Query: 1837 RQWVSYTIDFKDILERNCEEKDYTVWLAHSTDPGDYGDGCILGYKEQYLRLRKSSVCQNG 2016
              W+   ++  D L   C E DY +W    +   + G+ C+LG+K  + R    + C NG
Sbjct: 608  HSWLILQVNATDALGVPCTENDYKLW----SPSDERGNECLLGHKTVFKRRTPHATCFNG 663

Query: 2017 RDYVVTKQPSVCPCSLEDFLCDFGYFRPENDS--KCVEQPELKGHDLE---FCLYGREEH 2181
             D+      S C C+ ED+ CDFG+   E+ S   CV  PE  G        C  G   +
Sbjct: 664  EDFDRPVVVSNCSCTREDYECDFGFKMSEDLSLEVCVPDPEFSGKSYSPPVPCPVG-STY 722

Query: 2182 LTTNGYRKIPGDRCQGGVNPAR 2247
              T GYRKI GD C GG   AR
Sbjct: 723  RRTRGYRKISGDTCSGGDVEAR 744


>ref|NP_065828.2| VPS10 domain-containing receptor SorCS2 precursor [Homo sapiens].
          Length = 1159

 Score =  228 bits (580), Expect = 3e-59
 Identities = 170/655 (25%), Positives = 309/655 (47%), Gaps = 32/655 (4%)
 Frame = +1

Query: 370  DDLSGSVSLSWVGDSTGIILVLTTFHVPLVIMTFGQSKLYRSEDYGKNFKDITNLINNTF 549
            D       + W G+++ +IL+LT ++   +     +S L+RS D+G ++  +T     T 
Sbjct: 144  DATHNQAMVHWTGENSSVILILTKYYHADMGKVL-ESSLWRSSDFGTSYTKLTLQPGVTT 202

Query: 550  IRTEFGMAIGPENSGKVILTAEVSGGSHGGRIFRSSDFAKNFIQTNLPFHPLTQMMYSPQ 729
            +   F   I P N  KVIL +  S       +F S+D    F +  +PF   T +++ P+
Sbjct: 203  VIDNF--YICPTNKRKVILVSS-SLSDRDQSLFLSADEGATFQKQPIPFFVET-LIFHPK 258

Query: 730  NSDHLLALSTENGLWVSKNFGGKWEEIHKAVCLAKWGSDSTIFFTTYVNGSCKADLGALE 909
              D +LA + E+ L+VS + G KW  + + V       D   +  + V+     DL  +E
Sbjct: 259  EEDKVLAYTKESKLYVSSDLGKKWTLLQERVT-----KDHVFWSVSGVDAD--PDLVHVE 311

Query: 910  LRRTSDLGKSFKTIGVKIY------------------SFGLGGRFLFASVMADKDTTRRI 1035
             +   DLG  F+ +   I+                  S  +   ++F    +   T  + 
Sbjct: 312  AQ---DLGGDFRYVTCAIHNCSEKMLTAPFAGPIDHGSLTVQDDYIFFKATSANQT--KY 366

Query: 1036 HVSTDQGDTWSMAQLPSVGQEQFYSILAANDDMVFMHVDEPGDTGFGTIFTSDDRGIVYS 1215
            +VS  + + + + +LP     +   I++ ++  VF+ V E        ++ SD RG+ Y+
Sbjct: 367  YVSYRRNE-FVLMKLPKYALPKDLQIISTDESQVFVAVQEWYQMDTYNLYQSDPRGVRYA 425

Query: 1216 KSLDRHLYTTTGGETDFTNVTSLRGVYMTSVLSE--DNSIQTMITFDQGGRWKHLRKPEN 1389
              L     +    E+   ++  +RGV    + ++  D  + T+IT+++G  W +LR P  
Sbjct: 426  LVLQDVRSSRQAEESVLIDILEVRGVKGVFLANQKIDGKVMTLITYNKGRDWDYLRPPS- 484

Query: 1390 SECDATAKNKN----ECSLHIHASYSISQKLNVPMAPLSEPNAVGIVIAHGSVGDAISVM 1557
               D   K  N    +C LH+H  ++ +  ++  +   ++  A G+++  G++G  +   
Sbjct: 485  --MDMNGKPTNCKPPDCHLHLHLRWADNPYVSGTVH--TKDTAPGLIMGAGNLGSQLVEY 540

Query: 1558 IPDVYISDDGGYSWLKMLEGPHYYTILDSGGIIVAIEHSSHPINVIKFSTDEGQCWQTYV 1737
              ++YI+ D G++W ++ E  H+   LD GG+IVAI+ +S P+ ++KFS DEG  W T+ 
Sbjct: 541  KEEMYITSDCGHTWRQVFEEEHHILYLDHGGVIVAIKDTSIPLKILKFSVDEGLTWSTHN 600

Query: 1738 FSREPIYFTGLASEPGARSMNISIWGFTESFLTRQWVSYTIDFKDILERNCEEKDYTVWL 1917
            F+   ++  GL SEPG  ++ ++++G         W    +DF+    R C E+DY+ W 
Sbjct: 601  FTSTSVFVDGLLSEPGDETLVMTVFGHIS--FRSDWELVKVDFRPSFSRQCGEEDYSSWE 658

Query: 1918 AHSTDPGDYGDGCILGYKEQYLRLRKSSVCQNGRDYVVTKQPSVCPCSLEDFLCDFGYFR 2097
              +      GD CI+G +  + + + +S C  GR +       VC C   DFLCD+G+ R
Sbjct: 659  LSNLQ----GDRCIMGQQRSFRKRKSTSWCIKGRSFTSALTSRVCECRDSDFLCDYGFER 714

Query: 2098 PEND----SKCVE----QPELKGHDLEFCLYGREEHLTTNGYRKIPGDRCQGGVN 2238
              +     +KC       P     D   C  G + + ++ GYRK+  + C+GGV+
Sbjct: 715  SSSSESSTNKCSANFWFNPLSPPDD---CALG-QTYTSSLGYRKVVSNVCEGGVD 765


>ref|NP_001193501.1| VPS10 domain-containing receptor SorCS1 isoform f precursor [Homo
            sapiens].
          Length = 1179

 Score =  225 bits (573), Expect = 2e-58
 Identities = 171/694 (24%), Positives = 323/694 (46%), Gaps = 28/694 (4%)
 Frame = +1

Query: 337  RLANNTHQHVFDDLSGSVSLSWVGDSTGIILVLTTFHVPLVIMTFGQSKLYRSEDYGKNF 516
            RL + T     D       + W G ++ +IL+LT  +    + +  +S L+RS DYG  +
Sbjct: 159  RLTSTTFALTGDSAHNQAMVHWSGHNSSVILILTKLY-DYNLGSITESSLWRSTDYGTTY 217

Query: 517  KDITNLINNTFIRTEFGMAIGPENSGKVILTAEVSGGSHGGRIFRSSDFAKNFIQTNLPF 696
            + + + +    I +   + + P N  K++L  +    S    +  SSD    + +  L F
Sbjct: 218  EKLNDKVGLKTILSY--LYVCPTNKRKIMLLTDPEIESS---LLISSDEGATYQKYRLNF 272

Query: 697  HPLTQMMYSPQNSDHLLALSTENGLWVSKNFGGKWEEIHKAVCLAKWGSDSTIFFTTYVN 876
            + +  +++ P+  D +LA S +  L+ S  FG +W+ I + V   +       F+ + + 
Sbjct: 273  Y-IQSLLFHPKQEDWILAYSQDQKLYSSAEFGRRWQLIQEGVVPNR-------FYWSVMG 324

Query: 877  GSCKADLGALELRRTSDLGKSFKTIGVKIY----------------SFGLGGRFLFASVM 1008
             + + DL  LE R T D    + T  ++                  S  +   ++F  + 
Sbjct: 325  SNKEPDLVHLEAR-TVDGHSHYLTCRMQNCTEANRNQPFPGYIDPDSLIVQDHYVFVQLT 383

Query: 1009 ADKDTTRRIHVSTDQGDTWSMAQLPSVGQEQFYSILAANDDMVFMHVDEPGDTGFGTIFT 1188
            +     R  +  + + + ++  +LP     +   +++ +++ VF  V E        ++ 
Sbjct: 384  SGG---RPHYYVSYRRNAFAQMKLPKYALPKDMHVISTDENQVFAAVQEWNQNDTYNLYI 440

Query: 1189 SDDRGIVYSKSLDRHLYTTTGGE----TDFTNVTSLRGVYMTSVLSEDNSIQTMITFDQG 1356
            SD RG+ ++ +L+ ++ ++ G E     D   V  ++G+++ +    DN ++T IT+++G
Sbjct: 441  SDTRGVYFTLALE-NVQSSRGPEGNIMIDLYEVAGIKGMFLANK-KIDNQVKTFITYNKG 498

Query: 1357 GRWKHLRKPENS-ECDATAKNKNECSLHIHASYSISQKLNVPMAPLSEPNAVGIVIAHGS 1533
              W+ L+ P+     D        CSLH+H   S +   +  +A  S+  A  I++A G+
Sbjct: 499  RDWRLLQAPDTDLRGDPVHCLLPYCSLHLHLKVSENPYTSGIIA--SKDTAPSIIVASGN 556

Query: 1534 VGDAISVMIPDVYISDDGGYSWLKMLEGPHYYTILDSGGIIVAIEHSSHPINVIKFSTDE 1713
            +G  +S     +++S D G +W ++ E  H    LD GG++VA++H+S PI  +  S DE
Sbjct: 557  IGSELSDTDISMFVSSDAGNTWRQIFEEEHSVLYLDQGGVLVAMKHTSLPIRHLWLSFDE 616

Query: 1714 GQCWQTYVFSREPIYFTGLASEPGARSMNISIWGFTESFLTRQWVSYTIDFKDILERNCE 1893
            G+ W  Y F+  P++  G+  EPG  ++ ++++G        +W    +D+K I +R C 
Sbjct: 617  GRSWSKYSFTSIPLFVDGVLGEPGEETLIMTVFGHFSH--RSEWQLVKVDYKSIFDRRCA 674

Query: 1894 EKDYTVWLAHSTDPGDYGDGCILGYKEQYLRLRKSSVCQNGRDYVVTKQPSVCPCSLEDF 2073
            E+DY  W  HS      G+ CI+G K  Y + +    C  G+ Y    +   C C+  DF
Sbjct: 675  EEDYRPWQLHS-----QGEACIMGAKRIYKKRKSERKCMQGK-YAGAMESEPCVCTEADF 728

Query: 2074 LCDFGYFRPENDSKCVEQPELKGHDL-EFCLYGREEHLTTNGYRKIPGDRCQGGVNPARE 2250
             CD+GY R  N  +C+         L + C  G + +L + GYRK+  + C  GV     
Sbjct: 729  DCDYGYERHSN-GQCLPAFWFNPSSLSKDCSLG-QSYLNSTGYRKVVSNNCTDGVREQYT 786

Query: 2251 VKDLKKKCTS------NFLSPEKQDSRPQGHNLS 2334
             K   +KC          ++ + + +  QGHN++
Sbjct: 787  AK--PQKCPGKAPRGLRIVTADGKLTAEQGHNVT 818


>ref|NP_001193500.1| VPS10 domain-containing receptor SorCS1 isoform e precursor [Homo
            sapiens].
          Length = 1159

 Score =  225 bits (573), Expect = 2e-58
 Identities = 171/694 (24%), Positives = 323/694 (46%), Gaps = 28/694 (4%)
 Frame = +1

Query: 337  RLANNTHQHVFDDLSGSVSLSWVGDSTGIILVLTTFHVPLVIMTFGQSKLYRSEDYGKNF 516
            RL + T     D       + W G ++ +IL+LT  +    + +  +S L+RS DYG  +
Sbjct: 159  RLTSTTFALTGDSAHNQAMVHWSGHNSSVILILTKLY-DYNLGSITESSLWRSTDYGTTY 217

Query: 517  KDITNLINNTFIRTEFGMAIGPENSGKVILTAEVSGGSHGGRIFRSSDFAKNFIQTNLPF 696
            + + + +    I +   + + P N  K++L  +    S    +  SSD    + +  L F
Sbjct: 218  EKLNDKVGLKTILSY--LYVCPTNKRKIMLLTDPEIESS---LLISSDEGATYQKYRLNF 272

Query: 697  HPLTQMMYSPQNSDHLLALSTENGLWVSKNFGGKWEEIHKAVCLAKWGSDSTIFFTTYVN 876
            + +  +++ P+  D +LA S +  L+ S  FG +W+ I + V   +       F+ + + 
Sbjct: 273  Y-IQSLLFHPKQEDWILAYSQDQKLYSSAEFGRRWQLIQEGVVPNR-------FYWSVMG 324

Query: 877  GSCKADLGALELRRTSDLGKSFKTIGVKIY----------------SFGLGGRFLFASVM 1008
             + + DL  LE R T D    + T  ++                  S  +   ++F  + 
Sbjct: 325  SNKEPDLVHLEAR-TVDGHSHYLTCRMQNCTEANRNQPFPGYIDPDSLIVQDHYVFVQLT 383

Query: 1009 ADKDTTRRIHVSTDQGDTWSMAQLPSVGQEQFYSILAANDDMVFMHVDEPGDTGFGTIFT 1188
            +     R  +  + + + ++  +LP     +   +++ +++ VF  V E        ++ 
Sbjct: 384  SGG---RPHYYVSYRRNAFAQMKLPKYALPKDMHVISTDENQVFAAVQEWNQNDTYNLYI 440

Query: 1189 SDDRGIVYSKSLDRHLYTTTGGE----TDFTNVTSLRGVYMTSVLSEDNSIQTMITFDQG 1356
            SD RG+ ++ +L+ ++ ++ G E     D   V  ++G+++ +    DN ++T IT+++G
Sbjct: 441  SDTRGVYFTLALE-NVQSSRGPEGNIMIDLYEVAGIKGMFLANK-KIDNQVKTFITYNKG 498

Query: 1357 GRWKHLRKPENS-ECDATAKNKNECSLHIHASYSISQKLNVPMAPLSEPNAVGIVIAHGS 1533
              W+ L+ P+     D        CSLH+H   S +   +  +A  S+  A  I++A G+
Sbjct: 499  RDWRLLQAPDTDLRGDPVHCLLPYCSLHLHLKVSENPYTSGIIA--SKDTAPSIIVASGN 556

Query: 1534 VGDAISVMIPDVYISDDGGYSWLKMLEGPHYYTILDSGGIIVAIEHSSHPINVIKFSTDE 1713
            +G  +S     +++S D G +W ++ E  H    LD GG++VA++H+S PI  +  S DE
Sbjct: 557  IGSELSDTDISMFVSSDAGNTWRQIFEEEHSVLYLDQGGVLVAMKHTSLPIRHLWLSFDE 616

Query: 1714 GQCWQTYVFSREPIYFTGLASEPGARSMNISIWGFTESFLTRQWVSYTIDFKDILERNCE 1893
            G+ W  Y F+  P++  G+  EPG  ++ ++++G        +W    +D+K I +R C 
Sbjct: 617  GRSWSKYSFTSIPLFVDGVLGEPGEETLIMTVFGHFSH--RSEWQLVKVDYKSIFDRRCA 674

Query: 1894 EKDYTVWLAHSTDPGDYGDGCILGYKEQYLRLRKSSVCQNGRDYVVTKQPSVCPCSLEDF 2073
            E+DY  W  HS      G+ CI+G K  Y + +    C  G+ Y    +   C C+  DF
Sbjct: 675  EEDYRPWQLHS-----QGEACIMGAKRIYKKRKSERKCMQGK-YAGAMESEPCVCTEADF 728

Query: 2074 LCDFGYFRPENDSKCVEQPELKGHDL-EFCLYGREEHLTTNGYRKIPGDRCQGGVNPARE 2250
             CD+GY R  N  +C+         L + C  G + +L + GYRK+  + C  GV     
Sbjct: 729  DCDYGYERHSN-GQCLPAFWFNPSSLSKDCSLG-QSYLNSTGYRKVVSNNCTDGVREQYT 786

Query: 2251 VKDLKKKCTS------NFLSPEKQDSRPQGHNLS 2334
             K   +KC          ++ + + +  QGHN++
Sbjct: 787  AK--PQKCPGKAPRGLRIVTADGKLTAEQGHNVT 818


>ref|NP_001193499.1| VPS10 domain-containing receptor SorCS1 isoform d precursor [Homo
            sapiens].
          Length = 1130

 Score =  225 bits (573), Expect = 2e-58
 Identities = 171/694 (24%), Positives = 323/694 (46%), Gaps = 28/694 (4%)
 Frame = +1

Query: 337  RLANNTHQHVFDDLSGSVSLSWVGDSTGIILVLTTFHVPLVIMTFGQSKLYRSEDYGKNF 516
            RL + T     D       + W G ++ +IL+LT  +    + +  +S L+RS DYG  +
Sbjct: 159  RLTSTTFALTGDSAHNQAMVHWSGHNSSVILILTKLY-DYNLGSITESSLWRSTDYGTTY 217

Query: 517  KDITNLINNTFIRTEFGMAIGPENSGKVILTAEVSGGSHGGRIFRSSDFAKNFIQTNLPF 696
            + + + +    I +   + + P N  K++L  +    S    +  SSD    + +  L F
Sbjct: 218  EKLNDKVGLKTILSY--LYVCPTNKRKIMLLTDPEIESS---LLISSDEGATYQKYRLNF 272

Query: 697  HPLTQMMYSPQNSDHLLALSTENGLWVSKNFGGKWEEIHKAVCLAKWGSDSTIFFTTYVN 876
            + +  +++ P+  D +LA S +  L+ S  FG +W+ I + V   +       F+ + + 
Sbjct: 273  Y-IQSLLFHPKQEDWILAYSQDQKLYSSAEFGRRWQLIQEGVVPNR-------FYWSVMG 324

Query: 877  GSCKADLGALELRRTSDLGKSFKTIGVKIY----------------SFGLGGRFLFASVM 1008
             + + DL  LE R T D    + T  ++                  S  +   ++F  + 
Sbjct: 325  SNKEPDLVHLEAR-TVDGHSHYLTCRMQNCTEANRNQPFPGYIDPDSLIVQDHYVFVQLT 383

Query: 1009 ADKDTTRRIHVSTDQGDTWSMAQLPSVGQEQFYSILAANDDMVFMHVDEPGDTGFGTIFT 1188
            +     R  +  + + + ++  +LP     +   +++ +++ VF  V E        ++ 
Sbjct: 384  SGG---RPHYYVSYRRNAFAQMKLPKYALPKDMHVISTDENQVFAAVQEWNQNDTYNLYI 440

Query: 1189 SDDRGIVYSKSLDRHLYTTTGGE----TDFTNVTSLRGVYMTSVLSEDNSIQTMITFDQG 1356
            SD RG+ ++ +L+ ++ ++ G E     D   V  ++G+++ +    DN ++T IT+++G
Sbjct: 441  SDTRGVYFTLALE-NVQSSRGPEGNIMIDLYEVAGIKGMFLANK-KIDNQVKTFITYNKG 498

Query: 1357 GRWKHLRKPENS-ECDATAKNKNECSLHIHASYSISQKLNVPMAPLSEPNAVGIVIAHGS 1533
              W+ L+ P+     D        CSLH+H   S +   +  +A  S+  A  I++A G+
Sbjct: 499  RDWRLLQAPDTDLRGDPVHCLLPYCSLHLHLKVSENPYTSGIIA--SKDTAPSIIVASGN 556

Query: 1534 VGDAISVMIPDVYISDDGGYSWLKMLEGPHYYTILDSGGIIVAIEHSSHPINVIKFSTDE 1713
            +G  +S     +++S D G +W ++ E  H    LD GG++VA++H+S PI  +  S DE
Sbjct: 557  IGSELSDTDISMFVSSDAGNTWRQIFEEEHSVLYLDQGGVLVAMKHTSLPIRHLWLSFDE 616

Query: 1714 GQCWQTYVFSREPIYFTGLASEPGARSMNISIWGFTESFLTRQWVSYTIDFKDILERNCE 1893
            G+ W  Y F+  P++  G+  EPG  ++ ++++G        +W    +D+K I +R C 
Sbjct: 617  GRSWSKYSFTSIPLFVDGVLGEPGEETLIMTVFGHFSH--RSEWQLVKVDYKSIFDRRCA 674

Query: 1894 EKDYTVWLAHSTDPGDYGDGCILGYKEQYLRLRKSSVCQNGRDYVVTKQPSVCPCSLEDF 2073
            E+DY  W  HS      G+ CI+G K  Y + +    C  G+ Y    +   C C+  DF
Sbjct: 675  EEDYRPWQLHS-----QGEACIMGAKRIYKKRKSERKCMQGK-YAGAMESEPCVCTEADF 728

Query: 2074 LCDFGYFRPENDSKCVEQPELKGHDL-EFCLYGREEHLTTNGYRKIPGDRCQGGVNPARE 2250
             CD+GY R  N  +C+         L + C  G + +L + GYRK+  + C  GV     
Sbjct: 729  DCDYGYERHSN-GQCLPAFWFNPSSLSKDCSLG-QSYLNSTGYRKVVSNNCTDGVREQYT 786

Query: 2251 VKDLKKKCTS------NFLSPEKQDSRPQGHNLS 2334
             K   +KC          ++ + + +  QGHN++
Sbjct: 787  AK--PQKCPGKAPRGLRIVTADGKLTAEQGHNVT 818


>ref|NP_001193498.1| VPS10 domain-containing receptor SorCS1 isoform c precursor [Homo
            sapiens].
          Length = 1179

 Score =  225 bits (573), Expect = 2e-58
 Identities = 171/694 (24%), Positives = 323/694 (46%), Gaps = 28/694 (4%)
 Frame = +1

Query: 337  RLANNTHQHVFDDLSGSVSLSWVGDSTGIILVLTTFHVPLVIMTFGQSKLYRSEDYGKNF 516
            RL + T     D       + W G ++ +IL+LT  +    + +  +S L+RS DYG  +
Sbjct: 159  RLTSTTFALTGDSAHNQAMVHWSGHNSSVILILTKLY-DYNLGSITESSLWRSTDYGTTY 217

Query: 517  KDITNLINNTFIRTEFGMAIGPENSGKVILTAEVSGGSHGGRIFRSSDFAKNFIQTNLPF 696
            + + + +    I +   + + P N  K++L  +    S    +  SSD    + +  L F
Sbjct: 218  EKLNDKVGLKTILSY--LYVCPTNKRKIMLLTDPEIESS---LLISSDEGATYQKYRLNF 272

Query: 697  HPLTQMMYSPQNSDHLLALSTENGLWVSKNFGGKWEEIHKAVCLAKWGSDSTIFFTTYVN 876
            + +  +++ P+  D +LA S +  L+ S  FG +W+ I + V   +       F+ + + 
Sbjct: 273  Y-IQSLLFHPKQEDWILAYSQDQKLYSSAEFGRRWQLIQEGVVPNR-------FYWSVMG 324

Query: 877  GSCKADLGALELRRTSDLGKSFKTIGVKIY----------------SFGLGGRFLFASVM 1008
             + + DL  LE R T D    + T  ++                  S  +   ++F  + 
Sbjct: 325  SNKEPDLVHLEAR-TVDGHSHYLTCRMQNCTEANRNQPFPGYIDPDSLIVQDHYVFVQLT 383

Query: 1009 ADKDTTRRIHVSTDQGDTWSMAQLPSVGQEQFYSILAANDDMVFMHVDEPGDTGFGTIFT 1188
            +     R  +  + + + ++  +LP     +   +++ +++ VF  V E        ++ 
Sbjct: 384  SGG---RPHYYVSYRRNAFAQMKLPKYALPKDMHVISTDENQVFAAVQEWNQNDTYNLYI 440

Query: 1189 SDDRGIVYSKSLDRHLYTTTGGE----TDFTNVTSLRGVYMTSVLSEDNSIQTMITFDQG 1356
            SD RG+ ++ +L+ ++ ++ G E     D   V  ++G+++ +    DN ++T IT+++G
Sbjct: 441  SDTRGVYFTLALE-NVQSSRGPEGNIMIDLYEVAGIKGMFLANK-KIDNQVKTFITYNKG 498

Query: 1357 GRWKHLRKPENS-ECDATAKNKNECSLHIHASYSISQKLNVPMAPLSEPNAVGIVIAHGS 1533
              W+ L+ P+     D        CSLH+H   S +   +  +A  S+  A  I++A G+
Sbjct: 499  RDWRLLQAPDTDLRGDPVHCLLPYCSLHLHLKVSENPYTSGIIA--SKDTAPSIIVASGN 556

Query: 1534 VGDAISVMIPDVYISDDGGYSWLKMLEGPHYYTILDSGGIIVAIEHSSHPINVIKFSTDE 1713
            +G  +S     +++S D G +W ++ E  H    LD GG++VA++H+S PI  +  S DE
Sbjct: 557  IGSELSDTDISMFVSSDAGNTWRQIFEEEHSVLYLDQGGVLVAMKHTSLPIRHLWLSFDE 616

Query: 1714 GQCWQTYVFSREPIYFTGLASEPGARSMNISIWGFTESFLTRQWVSYTIDFKDILERNCE 1893
            G+ W  Y F+  P++  G+  EPG  ++ ++++G        +W    +D+K I +R C 
Sbjct: 617  GRSWSKYSFTSIPLFVDGVLGEPGEETLIMTVFGHFSH--RSEWQLVKVDYKSIFDRRCA 674

Query: 1894 EKDYTVWLAHSTDPGDYGDGCILGYKEQYLRLRKSSVCQNGRDYVVTKQPSVCPCSLEDF 2073
            E+DY  W  HS      G+ CI+G K  Y + +    C  G+ Y    +   C C+  DF
Sbjct: 675  EEDYRPWQLHS-----QGEACIMGAKRIYKKRKSERKCMQGK-YAGAMESEPCVCTEADF 728

Query: 2074 LCDFGYFRPENDSKCVEQPELKGHDL-EFCLYGREEHLTTNGYRKIPGDRCQGGVNPARE 2250
             CD+GY R  N  +C+         L + C  G + +L + GYRK+  + C  GV     
Sbjct: 729  DCDYGYERHSN-GQCLPAFWFNPSSLSKDCSLG-QSYLNSTGYRKVVSNNCTDGVREQYT 786

Query: 2251 VKDLKKKCTS------NFLSPEKQDSRPQGHNLS 2334
             K   +KC          ++ + + +  QGHN++
Sbjct: 787  AK--PQKCPGKAPRGLRIVTADGKLTAEQGHNVT 818


>ref|NP_443150.3| VPS10 domain-containing receptor SorCS1 isoform a precursor [Homo
            sapiens].
          Length = 1168

 Score =  225 bits (573), Expect = 2e-58
 Identities = 171/694 (24%), Positives = 323/694 (46%), Gaps = 28/694 (4%)
 Frame = +1

Query: 337  RLANNTHQHVFDDLSGSVSLSWVGDSTGIILVLTTFHVPLVIMTFGQSKLYRSEDYGKNF 516
            RL + T     D       + W G ++ +IL+LT  +    + +  +S L+RS DYG  +
Sbjct: 159  RLTSTTFALTGDSAHNQAMVHWSGHNSSVILILTKLY-DYNLGSITESSLWRSTDYGTTY 217

Query: 517  KDITNLINNTFIRTEFGMAIGPENSGKVILTAEVSGGSHGGRIFRSSDFAKNFIQTNLPF 696
            + + + +    I +   + + P N  K++L  +    S    +  SSD    + +  L F
Sbjct: 218  EKLNDKVGLKTILSY--LYVCPTNKRKIMLLTDPEIESS---LLISSDEGATYQKYRLNF 272

Query: 697  HPLTQMMYSPQNSDHLLALSTENGLWVSKNFGGKWEEIHKAVCLAKWGSDSTIFFTTYVN 876
            + +  +++ P+  D +LA S +  L+ S  FG +W+ I + V   +       F+ + + 
Sbjct: 273  Y-IQSLLFHPKQEDWILAYSQDQKLYSSAEFGRRWQLIQEGVVPNR-------FYWSVMG 324

Query: 877  GSCKADLGALELRRTSDLGKSFKTIGVKIY----------------SFGLGGRFLFASVM 1008
             + + DL  LE R T D    + T  ++                  S  +   ++F  + 
Sbjct: 325  SNKEPDLVHLEAR-TVDGHSHYLTCRMQNCTEANRNQPFPGYIDPDSLIVQDHYVFVQLT 383

Query: 1009 ADKDTTRRIHVSTDQGDTWSMAQLPSVGQEQFYSILAANDDMVFMHVDEPGDTGFGTIFT 1188
            +     R  +  + + + ++  +LP     +   +++ +++ VF  V E        ++ 
Sbjct: 384  SGG---RPHYYVSYRRNAFAQMKLPKYALPKDMHVISTDENQVFAAVQEWNQNDTYNLYI 440

Query: 1189 SDDRGIVYSKSLDRHLYTTTGGE----TDFTNVTSLRGVYMTSVLSEDNSIQTMITFDQG 1356
            SD RG+ ++ +L+ ++ ++ G E     D   V  ++G+++ +    DN ++T IT+++G
Sbjct: 441  SDTRGVYFTLALE-NVQSSRGPEGNIMIDLYEVAGIKGMFLANK-KIDNQVKTFITYNKG 498

Query: 1357 GRWKHLRKPENS-ECDATAKNKNECSLHIHASYSISQKLNVPMAPLSEPNAVGIVIAHGS 1533
              W+ L+ P+     D        CSLH+H   S +   +  +A  S+  A  I++A G+
Sbjct: 499  RDWRLLQAPDTDLRGDPVHCLLPYCSLHLHLKVSENPYTSGIIA--SKDTAPSIIVASGN 556

Query: 1534 VGDAISVMIPDVYISDDGGYSWLKMLEGPHYYTILDSGGIIVAIEHSSHPINVIKFSTDE 1713
            +G  +S     +++S D G +W ++ E  H    LD GG++VA++H+S PI  +  S DE
Sbjct: 557  IGSELSDTDISMFVSSDAGNTWRQIFEEEHSVLYLDQGGVLVAMKHTSLPIRHLWLSFDE 616

Query: 1714 GQCWQTYVFSREPIYFTGLASEPGARSMNISIWGFTESFLTRQWVSYTIDFKDILERNCE 1893
            G+ W  Y F+  P++  G+  EPG  ++ ++++G        +W    +D+K I +R C 
Sbjct: 617  GRSWSKYSFTSIPLFVDGVLGEPGEETLIMTVFGHFSH--RSEWQLVKVDYKSIFDRRCA 674

Query: 1894 EKDYTVWLAHSTDPGDYGDGCILGYKEQYLRLRKSSVCQNGRDYVVTKQPSVCPCSLEDF 2073
            E+DY  W  HS      G+ CI+G K  Y + +    C  G+ Y    +   C C+  DF
Sbjct: 675  EEDYRPWQLHS-----QGEACIMGAKRIYKKRKSERKCMQGK-YAGAMESEPCVCTEADF 728

Query: 2074 LCDFGYFRPENDSKCVEQPELKGHDL-EFCLYGREEHLTTNGYRKIPGDRCQGGVNPARE 2250
             CD+GY R  N  +C+         L + C  G + +L + GYRK+  + C  GV     
Sbjct: 729  DCDYGYERHSN-GQCLPAFWFNPSSLSKDCSLG-QSYLNSTGYRKVVSNNCTDGVREQYT 786

Query: 2251 VKDLKKKCTS------NFLSPEKQDSRPQGHNLS 2334
             K   +KC          ++ + + +  QGHN++
Sbjct: 787  AK--PQKCPGKAPRGLRIVTADGKLTAEQGHNVT 818


>ref|NP_001013049.1| VPS10 domain-containing receptor SorCS1 isoform b precursor [Homo
            sapiens].
          Length = 1198

 Score =  225 bits (573), Expect = 2e-58
 Identities = 171/694 (24%), Positives = 323/694 (46%), Gaps = 28/694 (4%)
 Frame = +1

Query: 337  RLANNTHQHVFDDLSGSVSLSWVGDSTGIILVLTTFHVPLVIMTFGQSKLYRSEDYGKNF 516
            RL + T     D       + W G ++ +IL+LT  +    + +  +S L+RS DYG  +
Sbjct: 159  RLTSTTFALTGDSAHNQAMVHWSGHNSSVILILTKLY-DYNLGSITESSLWRSTDYGTTY 217

Query: 517  KDITNLINNTFIRTEFGMAIGPENSGKVILTAEVSGGSHGGRIFRSSDFAKNFIQTNLPF 696
            + + + +    I +   + + P N  K++L  +    S    +  SSD    + +  L F
Sbjct: 218  EKLNDKVGLKTILSY--LYVCPTNKRKIMLLTDPEIESS---LLISSDEGATYQKYRLNF 272

Query: 697  HPLTQMMYSPQNSDHLLALSTENGLWVSKNFGGKWEEIHKAVCLAKWGSDSTIFFTTYVN 876
            + +  +++ P+  D +LA S +  L+ S  FG +W+ I + V   +       F+ + + 
Sbjct: 273  Y-IQSLLFHPKQEDWILAYSQDQKLYSSAEFGRRWQLIQEGVVPNR-------FYWSVMG 324

Query: 877  GSCKADLGALELRRTSDLGKSFKTIGVKIY----------------SFGLGGRFLFASVM 1008
             + + DL  LE R T D    + T  ++                  S  +   ++F  + 
Sbjct: 325  SNKEPDLVHLEAR-TVDGHSHYLTCRMQNCTEANRNQPFPGYIDPDSLIVQDHYVFVQLT 383

Query: 1009 ADKDTTRRIHVSTDQGDTWSMAQLPSVGQEQFYSILAANDDMVFMHVDEPGDTGFGTIFT 1188
            +     R  +  + + + ++  +LP     +   +++ +++ VF  V E        ++ 
Sbjct: 384  SGG---RPHYYVSYRRNAFAQMKLPKYALPKDMHVISTDENQVFAAVQEWNQNDTYNLYI 440

Query: 1189 SDDRGIVYSKSLDRHLYTTTGGE----TDFTNVTSLRGVYMTSVLSEDNSIQTMITFDQG 1356
            SD RG+ ++ +L+ ++ ++ G E     D   V  ++G+++ +    DN ++T IT+++G
Sbjct: 441  SDTRGVYFTLALE-NVQSSRGPEGNIMIDLYEVAGIKGMFLANK-KIDNQVKTFITYNKG 498

Query: 1357 GRWKHLRKPENS-ECDATAKNKNECSLHIHASYSISQKLNVPMAPLSEPNAVGIVIAHGS 1533
              W+ L+ P+     D        CSLH+H   S +   +  +A  S+  A  I++A G+
Sbjct: 499  RDWRLLQAPDTDLRGDPVHCLLPYCSLHLHLKVSENPYTSGIIA--SKDTAPSIIVASGN 556

Query: 1534 VGDAISVMIPDVYISDDGGYSWLKMLEGPHYYTILDSGGIIVAIEHSSHPINVIKFSTDE 1713
            +G  +S     +++S D G +W ++ E  H    LD GG++VA++H+S PI  +  S DE
Sbjct: 557  IGSELSDTDISMFVSSDAGNTWRQIFEEEHSVLYLDQGGVLVAMKHTSLPIRHLWLSFDE 616

Query: 1714 GQCWQTYVFSREPIYFTGLASEPGARSMNISIWGFTESFLTRQWVSYTIDFKDILERNCE 1893
            G+ W  Y F+  P++  G+  EPG  ++ ++++G        +W    +D+K I +R C 
Sbjct: 617  GRSWSKYSFTSIPLFVDGVLGEPGEETLIMTVFGHFSH--RSEWQLVKVDYKSIFDRRCA 674

Query: 1894 EKDYTVWLAHSTDPGDYGDGCILGYKEQYLRLRKSSVCQNGRDYVVTKQPSVCPCSLEDF 2073
            E+DY  W  HS      G+ CI+G K  Y + +    C  G+ Y    +   C C+  DF
Sbjct: 675  EEDYRPWQLHS-----QGEACIMGAKRIYKKRKSERKCMQGK-YAGAMESEPCVCTEADF 728

Query: 2074 LCDFGYFRPENDSKCVEQPELKGHDL-EFCLYGREEHLTTNGYRKIPGDRCQGGVNPARE 2250
             CD+GY R  N  +C+         L + C  G + +L + GYRK+  + C  GV     
Sbjct: 729  DCDYGYERHSN-GQCLPAFWFNPSSLSKDCSLG-QSYLNSTGYRKVVSNNCTDGVREQYT 786

Query: 2251 VKDLKKKCTS------NFLSPEKQDSRPQGHNLS 2334
             K   +KC          ++ + + +  QGHN++
Sbjct: 787  AK--PQKCPGKAPRGLRIVTADGKLTAEQGHNVT 818


  Database: RefSeq49_HP.fasta
    Posted date:  Oct 17, 2011  1:42 PM
  Number of letters in database: 18,297,164
  Number of sequences in database:  32,964
  
Lambda     K      H
   0.318    0.134    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 32964
Number of Hits to DB: 110,276,413
Number of extensions: 3107928
Number of successful extensions: 10046
Number of sequences better than 1.0e-05: 11
Number of HSP's gapped: 9976
Number of HSP's successfully gapped: 23
Length of query: 909
Length of database: 18,297,164
Length adjustment: 112
Effective length of query: 797
Effective length of database: 14,605,196
Effective search space: 11640341212
Effective search space used: 11640341212
Neighboring words threshold: 12
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 36 (18.5 bits)

BLASTX 2.2.24 [Aug-08-2010]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= 20110601C-002457
         (2728 letters)

Database: RefSeq49_MP.fasta 
           30,036 sequences; 15,617,559 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

Alignment   gi|NP_064356.2| sortilin precursor [Mus musculus].                  1408   0.0  
Alignment   gi|NP_035566.2| sortilin-related receptor [Mus musculus].            238   1e-62
Alignment   gi|NP_112151.2| VPS10 domain-containing receptor SorCS2 precurs...   226   9e-59
Alignment   gi|NP_067352.2| VPS10 domain-containing receptor SorCS1 [Mus mu...   224   3e-58
Alignment   gi|NP_079972.1| VPS10 domain-containing receptor SorCS3 precurs...   202   1e-51

>ref|NP_064356.2| sortilin precursor [Mus musculus].
          Length = 825

 Score = 1408 bits (3644), Expect = 0.0
 Identities = 689/817 (84%), Positives = 727/817 (88%)
 Frame = +1

Query: 64   GAAQGLSRWPHGLGXXXXXXXXLLPPASLGQDRLDXXXXXXXXLSRWSGPVGVSWGLXXX 243
            GAA GL RWP GL         LLPPA++GQDRLD        L RW+GPVGVSWGL   
Sbjct: 6    GAADGLLRWPLGL----LLLLQLLPPAAVGQDRLDAPPPPAPPLLRWAGPVGVSWGLRAA 61

Query: 244  XXXXXXXXXXXWRRSALDEDEDCGGVRDFVARLANNTHQHVFDDLSGSVSLSWVGDSTGI 423
                       WRR A  ED+DCG + DF+A+L NNTHQHVFDDLSGSVSLSWVGDSTG+
Sbjct: 62   APGGPVPRAGRWRRGAPAEDQDCGRLPDFIAKLTNNTHQHVFDDLSGSVSLSWVGDSTGV 121

Query: 424  ILVLTTFHVPLVIMTFGQSKLYRSEDYGKNFKDITNLINNTFIRTEFGMAIGPENSGKVI 603
            ILVLTTF VPLVI++FGQSKLYRSEDYGKNFKDITNLINNTFIRTEFGMAIGPENSGKVI
Sbjct: 122  ILVLTTFQVPLVIVSFGQSKLYRSEDYGKNFKDITNLINNTFIRTEFGMAIGPENSGKVI 181

Query: 604  LTAEVSGGSHGGRIFRSSDFAKNFIQTNLPFHPLTQMMYSPQNSDHLLALSTENGLWVSK 783
            LTAEVSGGS GGR+FRSSDFAKNF+QT+LPFHPLTQMMYSPQNSD+LLALSTENGLWVSK
Sbjct: 182  LTAEVSGGSRGGRVFRSSDFAKNFVQTDLPFHPLTQMMYSPQNSDYLLALSTENGLWVSK 241

Query: 784  NFGGKWEEIHKAVCLAKWGSDSTIFFTTYVNGSCKADLGALELRRTSDLGKSFKTIGVKI 963
            NFG KWEEIHKAVCLAKWG ++ IFFTT+VNGSCKADLGALEL RTSDLGK+FKTIGVKI
Sbjct: 242  NFGEKWEEIHKAVCLAKWGPNNIIFFTTHVNGSCKADLGALELWRTSDLGKTFKTIGVKI 301

Query: 964  YSFGLGGRFLFASVMADKDTTRRIHVSTDQGDTWSMAQLPSVGQEQFYSILAANDDMVFM 1143
            YSFGLGGRFLFASVMADKDTTRRIHVSTDQGDTWSMAQLPSVGQEQFYSILAAN+DMVFM
Sbjct: 302  YSFGLGGRFLFASVMADKDTTRRIHVSTDQGDTWSMAQLPSVGQEQFYSILAANEDMVFM 361

Query: 1144 HVDEPGDTGFGTIFTSDDRGIVYSKSLDRHLYTTTGGETDFTNVTSLRGVYMTSVLSEDN 1323
            HVDEPGDTGFGTIFTSDDRGIVYSKSLDRHLYTTTGGETDFTNVTSLRGVY+TS LSEDN
Sbjct: 362  HVDEPGDTGFGTIFTSDDRGIVYSKSLDRHLYTTTGGETDFTNVTSLRGVYITSTLSEDN 421

Query: 1324 SIQTMITFDQGGRWKHLRKPENSECDATAKNKNECSLHIHASYSISQKLNVPMAPLSEPN 1503
            SIQ+MITFDQGGRW+HLRKPENS+CDATAKNKNECSLHIHASYSISQKLNVPMAPLSEPN
Sbjct: 422  SIQSMITFDQGGRWEHLRKPENSKCDATAKNKNECSLHIHASYSISQKLNVPMAPLSEPN 481

Query: 1504 AVGIVIAHGSVGDAISVMIPDVYISDDGGYSWLKMLEGPHYYTILDSGGIIVAIEHSSHP 1683
            AVGIVIAHGSVGDAISVM+PDVYISDDGGYSW KMLEGPHYYTILDSGGIIVAIEHS+ P
Sbjct: 482  AVGIVIAHGSVGDAISVMVPDVYISDDGGYSWAKMLEGPHYYTILDSGGIIVAIEHSNRP 541

Query: 1684 INVIKFSTDEGQCWQTYVFSREPIYFTGLASEPGARSMNISIWGFTESFLTRQWVSYTID 1863
            INVIKFSTDEGQCWQ+YVF++EPIYFTGLASEPGARSMNISIWGFTESF+TRQWVSYT+D
Sbjct: 542  INVIKFSTDEGQCWQSYVFTQEPIYFTGLASEPGARSMNISIWGFTESFITRQWVSYTVD 601

Query: 1864 FKDILERNCEEKDYTVWLAHSTDPGDYGDGCILGYKEQYLRLRKSSVCQNGRDYVVTKQP 2043
            FKDILERNCEE DYT WLAHSTDPGDY DGCILGYKEQ+LRLRKSSVCQNGRDYVV KQP
Sbjct: 602  FKDILERNCEEDDYTTWLAHSTDPGDYKDGCILGYKEQFLRLRKSSVCQNGRDYVVAKQP 661

Query: 2044 SVCPCSLEDFLCDFGYFRPENDSKCVEQPELKGHDLEFCLYGREEHLTTNGYRKIPGDRC 2223
            SVCPCSLEDFLCDFGYFRPEN S+CVEQPELKGH+LEFCLYG+EEHLTTNGYRKIPGD+C
Sbjct: 662  SVCPCSLEDFLCDFGYFRPENASECVEQPELKGHELEFCLYGKEEHLTTNGYRKIPGDKC 721

Query: 2224 QGGVNPAREVKDLKKKCTSNFLSPEKQDSRPQGHNLSQNPAPPPLGYTENTHSLSPTQKQ 2403
            QGG+NPAREVKDLKKKCTSNFL+P                                  KQ
Sbjct: 722  QGGMNPAREVKDLKKKCTSNFLNP---------------------------------TKQ 748

Query: 2404 NSKSSSVPIILATVGLMLVTVVAGVLIVKKYVCGGRF 2514
            NSKS+SVPIILA VGLMLVTVVAGVLIVKKYVCGGRF
Sbjct: 749  NSKSNSVPIILAIVGLMLVTVVAGVLIVKKYVCGGRF 785



 Score = 43.1 bits (100), Expect(2) = 2e-07
 Identities = 22/30 (73%), Positives = 25/30 (83%)
 Frame = +3

Query: 2505 GKVLVHRYSVLQQHAEANGVDGVDALDTPS 2594
            G+ LVHRYSVLQQHAEA   DGV+ALD+ S
Sbjct: 783  GRFLVHRYSVLQQHAEA---DGVEALDSTS 809



 Score = 32.0 bits (71), Expect(2) = 2e-07
 Identities = 13/13 (100%), Positives = 13/13 (100%)
 Frame = +2

Query: 2603 KSGYHDDSDEDLL 2641
            KSGYHDDSDEDLL
Sbjct: 812  KSGYHDDSDEDLL 824


>ref|NP_035566.2| sortilin-related receptor [Mus musculus].
          Length = 2215

 Score =  238 bits (608), Expect = 1e-62
 Identities = 200/682 (29%), Positives = 321/682 (47%), Gaps = 56/682 (8%)
 Frame = +1

Query: 370  DDLSGSVSLSWVGDSTGIILVLTTFHVPLVIMTFGQSKLYRSEDYGKNFKDITNLINNTF 549
            +D    + + W G+ + +I+ L      L +     S +Y S DYGK+F  I+  +N   
Sbjct: 99   NDSHNQMVVHWAGEKSNVIVALA--RDSLALARPKSSDVYVSYDYGKSFSKISEKLN--- 153

Query: 550  IRTEFGMAIGPENSGKVILTAEVSGGSHGGRIFRSS---------DFAKNFIQTNLPFHP 702
                FG+     NS  VI     S   +   IF  +         DF       ++PF  
Sbjct: 154  ----FGVG---NNSEAVISQFYHSPADNKRYIFVDAYAQYLWITFDFCSTIHGFSIPFRA 206

Query: 703  LTQMMYSPQNSDHLLALSTENG---LWVSKNFGGKWEEIHKAVCLAKWGSD-----STIF 858
               +++S + S+ LL     +    LW S +FG  W  I + V    WG D     + I+
Sbjct: 207  ADLLLHS-KASNLLLGFDRSHPNKQLWKSDDFGQTWIMIQEHVKSFSWGIDPYDQPNAIY 265

Query: 859  FTTYVNGSCKADLGALELRRTSDLGKSFKTIGV---KIYSFGLGGRFLFASVM-----AD 1014
               +         G   + R++D  +S +   V   ++  F L  +++FA+ +     + 
Sbjct: 266  IERH------EPFGFSTVLRSTDFFQSRENQEVILEEVRDFQLRDKYMFATKVVHLPGSQ 319

Query: 1015 KDTTRRIHVSTDQGDTWSMAQLPSVGQEQFYSILAANDDMVFMHVDEPGDTGFGTIFTSD 1194
            + ++ ++ VS  +      AQ  +      Y I  A +D VF+ V    ++    ++ S+
Sbjct: 320  QQSSVQLWVSFGR-KPMRAAQFVTKHPINEYYIADAAEDQVFVCVSHSNNST--NLYISE 376

Query: 1195 DRGIVYSKSLDRHLYTTTGGE--------------TDFTNVTSLRGVYMTSVLS---EDN 1323
              G+ +S SL+  LY + GG                DF  V  L+GVY+ ++++    + 
Sbjct: 377  AEGLKFSLSLENVLYYSPGGAGSDTLVRYFANEPFADFHRVEGLQGVYIATLINGSMNEE 436

Query: 1324 SIQTMITFDQGGRWKHLRKP------ENSECDATAKNKNECSLHIHASYSISQKLNVP-- 1479
            +++++ITFD+GG W+ L+ P      E   C+ +      CSLH+  +  +SQ LN+   
Sbjct: 437  NMRSVITFDKGGTWEFLQAPAFTGYGEKINCELS----QGCSLHL--AQRLSQLLNLQLR 490

Query: 1480 -MAPLSEPNAVGIVIAHGSVGDAISVMIPDVYISDDGGYSWLKMLEGPHYYTILDSGGII 1656
             M  LS+ +A G++IA GSVG  ++    +VYIS   G  W + L GPHYYT  D GGII
Sbjct: 491  RMPILSKESAPGLIIATGSVGKNLASKT-NVYISSSAGARWREALPGPHYYTWGDHGGII 549

Query: 1657 VAIEHSSHPINVIKFSTDEGQCWQTYVFSREPIYFTGLASEPGARSMNISIWGFTESFLT 1836
            +AI       N +K+ST+EG+ W+T+VFS +P++  GL +EPG +S   +I+G  +  + 
Sbjct: 550  MAIAQGMET-NELKYSTNEGETWKTFVFSEKPVFVYGLLTEPGEKSTVFTIFGSNKESV- 607

Query: 1837 RQWVSYTIDFKDILERNCEEKDYTVWLAHSTDPGDYGDGCILGYKEQYLRLRKSSVCQNG 2016
              W+   ++  D L   C E DY +W    +   + G+ C+LG+K  + R    + C NG
Sbjct: 608  HSWLILQVNATDALGVPCTENDYKLW----SPSDERGNECLLGHKTVFKRRTPHATCFNG 663

Query: 2017 RDYVVTKQPSVCPCSLEDFLCDFGYFRPENDS--KCVEQPELKGHDLE---FCLYGREEH 2181
             D+      S C C+ ED+ CDFG+   E+ S   CV  PE  G        C  G   +
Sbjct: 664  EDFDRPVVVSNCSCTREDYECDFGFKMSEDLSLEVCVPDPEFSGKPYSPPVPCPVG-SSY 722

Query: 2182 LTTNGYRKIPGDRCQGGVNPAR 2247
              T GYRKI GD C GG   AR
Sbjct: 723  RRTRGYRKISGDTCSGGDVEAR 744


>ref|NP_112151.2| VPS10 domain-containing receptor SorCS2 precursor [Mus musculus].
          Length = 1159

 Score =  226 bits (575), Expect = 9e-59
 Identities = 167/652 (25%), Positives = 301/652 (46%), Gaps = 29/652 (4%)
 Frame = +1

Query: 370  DDLSGSVSLSWVGDSTGIILVLTTFHVPLVIMTFGQSKLYRSEDYGKNFKDITNLINNTF 549
            D       + W G+++ +IL+LT ++   +     +S L+RS D+G  +  +T     T 
Sbjct: 144  DATHNQAMVHWTGENSSVILILTKYYHADMGKVL-ESSLWRSSDFGTTYTKLTLQPGVTT 202

Query: 550  IRTEFGMAIGPENSGKVILTAEVSGGSHGGRIFRSSDFAKNFIQTNLPFHPLTQMMYSPQ 729
            +   F   I P N  K+IL +  S G     +F S+D    F +  +PF  +  +++ P+
Sbjct: 203  VIDNF--YICPANKRKIILVSS-SLGDREQSLFLSTDEGATFQKYPVPFL-VEMLLFHPK 258

Query: 730  NSDHLLALSTENGLWVSKNFGGKWEEIHKAVCLAKWGSDSTIFFTTYVNGSCKADLGALE 909
              D +LA + ++ L+VS + G KW  + + V       D   +  + V+     D   L 
Sbjct: 259  EEDKVLAYTKDSKLYVSSDLGKKWTLLQERVT-----KDHVFWAVSGVD-----DDPNLV 308

Query: 910  LRRTSDLGKSFKTIGVKIY------------------SFGLGGRFLFASVMADKDTTRRI 1035
                 DL   ++     IY                  S  +   ++F    +   T  + 
Sbjct: 309  HVEAQDLSGGYRYYTCLIYNCSAQPHIAPFSGPIDRGSLTVQDEYIFLKATSTNRT--KY 366

Query: 1036 HVSTDQGDTWSMAQLPSVGQEQFYSILAANDDMVFMHVDEPGDTGFGTIFTSDDRGIVYS 1215
            +VS  + D + + +LP     +   I++ ++  VF+ V E        ++ SD RG+ YS
Sbjct: 367  YVSYRRSD-FVLMKLPKYALPKDLQIISTDEQQVFVAVQEWNQVDTYNLYQSDLRGVRYS 425

Query: 1216 KSLDRHLYTTTGGETDFTNVTSLRGVYMTSVLSE--DNSIQTMITFDQGGRWKHLRKPEN 1389
              L+    +    E    ++  +RGV    + ++  D  + T+IT+++G  W +LR P  
Sbjct: 426  LVLENVRSSRQAEENVVIDILEVRGVKGVFLANQKVDGKVTTVITYNKGRDWDYLRPPST 485

Query: 1390 SECDATAKNKN----ECSLHIHASYSISQKLNVPMAPLSEPNAVGIVIAHGSVGDAISVM 1557
               D   K  N    +C LH+H  ++ +  ++  +   ++  A G+++  G++G  +   
Sbjct: 486  ---DMNGKPTNCQPPDCYLHLHLRWADNPYVSGTVH--TKDTAPGLIMGAGNLGSQLVEY 540

Query: 1558 IPDVYISDDGGYSWLKMLEGPHYYTILDSGGIIVAIEHSSHPINVIKFSTDEGQCWQTYV 1737
              ++YI+ D G++W ++ E  H+   LD GG+I AI+ +S P+ ++KFS DEG  W T+ 
Sbjct: 541  KEEMYITSDCGHTWRQVFEEEHHVLYLDHGGVIAAIKDTSIPLKILKFSVDEGHTWSTHN 600

Query: 1738 FSREPIYFTGLASEPGARSMNISIWGFTESFLTRQWVSYTIDFKDILERNCEEKDYTVWL 1917
            F+   ++  GL SEPG  ++ ++++G         W    +DF+    R C E DY+ W 
Sbjct: 601  FTSTSVFVDGLLSEPGDETLVMTVFGHIS--FRSDWELVKVDFRPSFPRQCGEDDYSSW- 657

Query: 1918 AHSTDPGDYGDGCILGYKEQYLRLRKSSVCQNGRDYVVTKQPSVCPCSLEDFLCDFGYFR 2097
               TD    GD CI+G +  Y + + +S C  GR +       VC C   DFLCD+G+ R
Sbjct: 658  -DLTDL--QGDHCIMGQQRSYRKRKSTSWCVKGRSFTSALTSRVCKCRDSDFLCDYGFER 714

Query: 2098 PENDSKCVEQPELKG-----HDLEFCLYGREEHLTTNGYRKIPGDRCQGGVN 2238
              +      +             E C+ G + + ++ GYRK+  + C+GGV+
Sbjct: 715  SSSSESTANKCSANFWFNPLSPPEDCVLG-QTYTSSLGYRKVVSNVCEGGVD 765


>ref|NP_067352.2| VPS10 domain-containing receptor SorCS1 [Mus musculus].
          Length = 1168

 Score =  224 bits (571), Expect = 3e-58
 Identities = 171/691 (24%), Positives = 320/691 (46%), Gaps = 25/691 (3%)
 Frame = +1

Query: 337  RLANNTHQHVFDDLSGSVSLSWVGDSTGIILVLTTFHVPLVIMTFGQSKLYRSEDYGKNF 516
            RL + T     D       + W G ++ +IL+LT  +    + +  +S L+RS DYG  +
Sbjct: 159  RLTSTTFALTGDSAHNQAMVHWSGHNSSVILILTKLY-DYNLGSITESSLWRSTDYGTTY 217

Query: 517  KDITNLINNTFIRTEFGMAIGPENSGKVILTAEVSGGSHGGRIFRSSDFAKNFIQTNLPF 696
            + + + +    I +   + + P N  K++L  +    S    +  SSD    + +  L F
Sbjct: 218  EKLNDKVGLKTILSY--LYVCPTNKRKIMLLTDPEIESS---LLISSDEGATYQKYRLNF 272

Query: 697  HPLTQMMYSPQNSDHLLALSTENGLWVSKNFGGKWEEIHKAVCLAKWGSDSTIFFTTYVN 876
            + +  +++ P+  D +LA S +  L+ S  FG +W+ I ++V   +       F+ + + 
Sbjct: 273  Y-IQSLLFHPKQEDWILAYSQDQKLYSSAEFGRRWQLIQESVVPNR-------FYWSVMG 324

Query: 877  GSCKADLGALELRRTSDLGKSFKTIGVKIYSFGLGGRFLFASVMADKDTTRRIHVSTD-- 1050
             S + DL  LE R T D    + T  ++  +     +     +  D    +  +V     
Sbjct: 325  SSKEPDLVHLEAR-TVDGHSIYLTCRMQNCTEANRNKPFPGYIDPDSLIVQDDYVFVQLT 383

Query: 1051 -----------QGDTWSMAQLPSVGQEQFYSILAANDDMVFMHVDEPGDTGFGTIFTSDD 1197
                       +   ++  +LP     +   +++ +++ VF  V E        ++ SD 
Sbjct: 384  SGGRPHYYVSYRRSPFAQMKLPKYALPKDMHVISTDENQVFAAVQEWNQNDTYNLYISDT 443

Query: 1198 RGIVYSKSLDRHLYTTTGGE----TDFTNVTSLRGVYMTSVLSEDNSIQTMITFDQGGRW 1365
            RG+ ++ +L+ ++ ++ G E     D   V  ++G+++ +    DN ++T IT+++G  W
Sbjct: 444  RGVYFTLALE-NVQSSRGPEGNVMIDLYEVAGIKGMFLANK-KIDNQVKTFITYNKGRDW 501

Query: 1366 KHLRKPE-NSECDATAKNKNECSLHIHASYSISQKLNVPMAPLSEPNAVGIVIAHGSVGD 1542
            + L+ P+ +   D        CSLH+H   S +   +  +A  S   A  I++A G++G 
Sbjct: 502  RLLQAPDADLRGDPVHCLLPYCSLHLHLKVSENPYTSGIIA--SRDTAPSIIVASGNIGS 559

Query: 1543 AISVMIPDVYISDDGGYSWLKMLEGPHYYTILDSGGIIVAIEHSSHPINVIKFSTDEGQC 1722
             +S     +++S D G +W ++ E  H    LD GG++VA++H+S PI  +  S DEG+ 
Sbjct: 560  ELSDSDISMFVSSDAGNTWRQIFEEEHSILYLDQGGVLVAMKHTSLPIRHLWLSFDEGRS 619

Query: 1723 WQTYVFSREPIYFTGLASEPGARSMNISIWGFTESFLTRQWVSYTIDFKDILERNCEEKD 1902
            W  Y F+  P++  G+  EPG  ++ ++++G        +W    +D+K I +R C E+D
Sbjct: 620  WSKYSFTSIPLFVDGVLGEPGEETLIMTVFGHFSH--RSEWQLVKVDYKSIFDRRCAEED 677

Query: 1903 YTVWLAHSTDPGDYGDGCILGYKEQYLRLRKSSVCQNGRDYVVTKQPSVCPCSLEDFLCD 2082
            Y  W  HS      G+ CI+G K  Y + +    C  G+ Y    +   C C+  DF CD
Sbjct: 678  YRPWQLHS-----QGEACIMGAKRIYKKRKSERKCMQGK-YAGAMESEPCVCTEADFDCD 731

Query: 2083 FGYFRPENDSKCVEQPELKGHDL-EFCLYGREEHLTTNGYRKIPGDRCQGGVNPAREVKD 2259
            +GY R  N  +C+         L + C  G + +L + GYRK+  + C  GV      K 
Sbjct: 732  YGYERHSN-GQCLPAFWFNPSSLSKDCSLG-QSYLNSTGYRKVVSNNCTDGVREQYTAK- 788

Query: 2260 LKKKCTS------NFLSPEKQDSRPQGHNLS 2334
              +KC          ++ + + +  QGHN++
Sbjct: 789  -PQKCPGKAPRGLRIVTADGKLTAEQGHNVT 818


>ref|NP_079972.1| VPS10 domain-containing receptor SorCS3 precursor [Mus musculus].
          Length = 1219

 Score =  202 bits (514), Expect = 1e-51
 Identities = 159/673 (23%), Positives = 315/673 (46%), Gaps = 25/673 (3%)
 Frame = +1

Query: 313  GGVRDFVARLANNTHQHVFDDLSGSVSLSWVGDSTGIILVLTTFHVPLVIMTFGQSKLYR 492
            GG      RL + +     D       + W G ++ +IL+LT  +    + +  +S L+R
Sbjct: 171  GGASTEELRLPSTSFALTGDSAHNQAMVHWSGHNSSVILILTKLY-DFNLGSVTESSLWR 229

Query: 493  SEDYGKNFKDITNLINNTFIRTEFGMAIGPENSGKVILTAEVSGGSHGGRIFRSSDFAKN 672
            S DYG  ++ + + +    + +   + + P N  K++L ++    S    +  SSD    
Sbjct: 230  SVDYGATYEKLNDKVGLKTVLSY--LYVNPTNKRKIMLLSDPEMESS---VLISSDEGAT 284

Query: 673  FIQTNLPFHPLTQMMYSPQNSDHLLALSTENGLWVSKNFGGKWEEIHKAVCLAKWGSDST 852
            + +  L F+ +  +++ P+  D +LA S +  L+ S +FG +W+ +H+ +   +      
Sbjct: 285  YQKYRLTFY-IQSLLFHPKQEDWVLAYSLDQKLYSSMDFGRRWQLMHERITPNR------ 337

Query: 853  IFFTTYVNGSCKADLGALELRRTSDLGKSFKTIGVK----------------IYSFGLGG 984
             F+ +      +ADL  +E+R T+D    + T  ++                I S  +  
Sbjct: 338  -FYWSVSGLDKEADLVHMEVR-TADGYAHYLTCRIQECAETTRSGPFARSIDISSLVVQD 395

Query: 985  RFLFASVMADKDTTRRIHVSTDQGDTWSMAQLPSVGQEQFYSILAANDDMVFMHVDEPGD 1164
             ++F  V       R  +  + + + ++  +LP     +   I++ +++ VF  V E   
Sbjct: 396  EYIFIQVTIGG---RASYYVSYRREAFAQIKLPKYSLPKDMHIISTDENQVFAAVQEWNQ 452

Query: 1165 TGFGTIFTSDDRGIVYSKSLDRHLYTTTG--GET--DFTNVTSLRGVYMTSVLSEDNSIQ 1332
                 ++ SD RGI ++ +++ ++ ++ G  G    +   V  ++G+++ +    D+ ++
Sbjct: 453  NDTYNLYISDTRGIYFTLAME-NIKSSRGLMGNIIIELYEVAGIKGIFLANK-KVDDQVK 510

Query: 1333 TMITFDQGGRWKHLRKPENSECDATAKNKNE-CSLHIHASYSISQKLNVPMAPLSEPNAV 1509
            T IT+++G  W+ L+ P+     +        CSLH+H   S +   +  ++  S+  A 
Sbjct: 511  TYITYNKGRDWRLLQAPDVDLRGSPVHCLLPFCSLHLHLQLSENPYSSGRIS--SKDTAP 568

Query: 1510 GIVIAHGSVGDAISVMIPDVYISDDGGYSWLKMLEGPHYYTILDSGGIIVAIEHSSHPIN 1689
            G+V+A G++G  +S     V+IS DGG +W ++ +  +    LD GG +VA++H+  P+ 
Sbjct: 569  GLVVATGNIGSELSYTDIGVFISSDGGNTWRQIFDEEYNVWFLDWGGALVAMKHTPLPVR 628

Query: 1690 VIKFSTDEGQCWQTYVFSREPIYFTGLASEPGARSMNISIWGFTESFLTRQWVSYTIDFK 1869
             +  S DEG  W  Y F+  P++  G   E G  +  ++++G     L  +W    +D+K
Sbjct: 629  HLWVSFDEGHSWDKYGFTLLPLFVDGALVEAGVETHIMTVFGHFS--LRSEWQLVKVDYK 686

Query: 1870 DILERNCEEKDYTVWLAHSTDPGDYGDGCILGYKEQYLRLRKSSVCQNGRDYVVTKQPSV 2049
             I  R C ++D+  W  H     + G+ C++G ++ + + +  + C  GR+Y  +     
Sbjct: 687  SIFSRRCTKEDFETW--HLL---NQGEPCVMGERKIFKKRKPGAQCALGREYSGSVVSEP 741

Query: 2050 CPCSLEDFLCDFGYFRPENDSKCVE----QPELKGHDLEFCLYGREEHLTTNGYRKIPGD 2217
            C C+  DF CD+GY R   +S+CV      P     D   C  G + +L + GYR+I  +
Sbjct: 742  CVCADWDFECDYGYER-HGESQCVPAFWYNPASPSKD---CSLG-QSYLNSTGYRRIVSN 796

Query: 2218 RCQGGVNPAREVK 2256
             C  G+      K
Sbjct: 797  NCTDGLRDKYSAK 809


  Database: RefSeq49_MP.fasta
    Posted date:  Oct 17, 2011  1:42 PM
  Number of letters in database: 15,617,559
  Number of sequences in database:  30,036
  
Lambda     K      H
   0.318    0.134    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 30036
Number of Hits to DB: 93,277,836
Number of extensions: 2604970
Number of successful extensions: 8148
Number of sequences better than 1.0e-05: 5
Number of HSP's gapped: 8107
Number of HSP's successfully gapped: 10
Length of query: 909
Length of database: 15,617,559
Length adjustment: 110
Effective length of query: 799
Effective length of database: 12,313,599
Effective search space: 9838565601
Effective search space used: 9838565601
Neighboring words threshold: 12
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 36 (18.5 bits)

BLASTX 2.2.24 [Aug-08-2010]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= 20110601C-002457
         (2728 letters)

Database: RefSeq49_SP.fasta 
           24,897 sequences; 11,343,932 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

Alignment   gi|XP_003125920.2| PREDICTED: sortilin [Sus scrofa].                1384   0.0  
Alignment   gi|XP_003359412.1| PREDICTED: VPS10 domain-containing receptor ...   226   4e-59
Alignment   gi|XP_003359411.1| PREDICTED: VPS10 domain-containing receptor ...   226   4e-59
Alignment   gi|XP_001924753.1| PREDICTED: VPS10 domain-containing receptor ...   226   4e-59
Alignment   gi|XP_003359410.1| PREDICTED: VPS10 domain-containing receptor ...   226   4e-59
Alignment   gi|XP_001924739.1| PREDICTED: VPS10 domain-containing receptor ...   226   4e-59
Alignment   gi|XP_003359409.1| PREDICTED: VPS10 domain-containing receptor ...   226   4e-59
Alignment   gi|XP_003133227.2| PREDICTED: VPS10 domain-containing receptor ...   204   3e-52
Alignment   gi|XP_003356901.1| PREDICTED: VPS10 domain-containing receptor ...   193   5e-49

>ref|XP_003125920.2| PREDICTED: sortilin [Sus scrofa].
          Length = 772

 Score = 1384 bits (3583), Expect = 0.0
 Identities = 683/719 (94%), Positives = 684/719 (95%)
 Frame = +1

Query: 358  QHVFDDLSGSVSLSWVGDSTGIILVLTTFHVPLVIMTFGQSKLYRSEDYGKNFKDITNLI 537
            +HVFDDLSGSVSLSWVGDSTGIILVLTTFHVPLVIMTFGQSKLYRSEDYGKNFKDITNLI
Sbjct: 44   KHVFDDLSGSVSLSWVGDSTGIILVLTTFHVPLVIMTFGQSKLYRSEDYGKNFKDITNLI 103

Query: 538  NNTFIRTEFGMAIGPENSGKVILTAEVSGGSHGGRIFRSSDFAKNFIQTNLPFHPLTQMM 717
            NNTFIRTEFGMAIGPENSGKVILTAEVSGGSHGGRIFRSSDFAKNFIQTNLPFHPLTQMM
Sbjct: 104  NNTFIRTEFGMAIGPENSGKVILTAEVSGGSHGGRIFRSSDFAKNFIQTNLPFHPLTQMM 163

Query: 718  YSPQNSDHLLALSTENGLWVSKNFGGKWEEIHKAVCLAKWGSDSTIFFTTYVNGSCKADL 897
            YSPQNSDHLLALSTENGLWVSKNFGGKWEEIHKAVCLAKWGSDSTIFFTTYVNGSC  DL
Sbjct: 164  YSPQNSDHLLALSTENGLWVSKNFGGKWEEIHKAVCLAKWGSDSTIFFTTYVNGSC-TDL 222

Query: 898  GALELRRTSDLGKSFKTIGVKIYSFGLGGRFLFASVMADKDTTRRIHVSTDQGDTWSMAQ 1077
            GALELRRTSDLGKSFKTIGVKIYSFGLGGRFLFASVMADKDTTRRIHVSTDQGDTWSMAQ
Sbjct: 223  GALELRRTSDLGKSFKTIGVKIYSFGLGGRFLFASVMADKDTTRRIHVSTDQGDTWSMAQ 282

Query: 1078 LPSVGQEQFYSILAANDDMVFMHVDEPGDTGFGTIFTSDDRGIVYSKSLDRHLYTTTGGE 1257
            LPSVGQEQFYSILAANDDMVFMHVDEPGDTGFGTIFTSDDRGIVYSKSLDRHLYTTTGGE
Sbjct: 283  LPSVGQEQFYSILAANDDMVFMHVDEPGDTGFGTIFTSDDRGIVYSKSLDRHLYTTTGGE 342

Query: 1258 TDFTNVTSLRGVYMTSVLSEDNSIQTMITFDQGGRWKHLRKPENSECDATAKNKNECSLH 1437
            TDFTNVTSLRGVYMTSVLSEDNSIQTMITFDQGGRWKHLRKPENSECDATAKNKNECSLH
Sbjct: 343  TDFTNVTSLRGVYMTSVLSEDNSIQTMITFDQGGRWKHLRKPENSECDATAKNKNECSLH 402

Query: 1438 IHASYSISQKLNVPMAPLSEPNAVGIVIAHGSVGDAISVMIPDVYISDDGGYSWLKMLEG 1617
            IHASYSISQKLNVPMAPLSEPNAVGIVIAHGSVGDAISVMIPDVYISDDGGYSWLKMLEG
Sbjct: 403  IHASYSISQKLNVPMAPLSEPNAVGIVIAHGSVGDAISVMIPDVYISDDGGYSWLKMLEG 462

Query: 1618 PHYYTILDSGGIIVAIEHSSHPINVIKFSTDEGQCWQTYVFSREPIYFTGLASEPGARSM 1797
            PHYYTILDSGGIIVAIEHSSHPINVIKFSTDEGQCWQTYVFSREPIYFTGLASEPGARSM
Sbjct: 463  PHYYTILDSGGIIVAIEHSSHPINVIKFSTDEGQCWQTYVFSREPIYFTGLASEPGARSM 522

Query: 1798 NISIWGFTESFLTRQWVSYTIDFKDILERNCEEKDYTVWLAHSTDPGDYGDGCILGYKEQ 1977
            NISIWGFTESFLTRQWVSYTIDFKDILERNCEEKDYTVWLAHSTDPGDYGDGCILGYKEQ
Sbjct: 523  NISIWGFTESFLTRQWVSYTIDFKDILERNCEEKDYTVWLAHSTDPGDYGDGCILGYKEQ 582

Query: 1978 YLRLRKSSVCQNGRDYVVTKQPSVCPCSLEDFLCDFGYFRPENDSKCVEQPELKGHDLEF 2157
            YLRLRKSSVCQNGRDYVVTKQPSVCPCSLEDFLCDFGYFRPENDSKCVEQPELKGHDLEF
Sbjct: 583  YLRLRKSSVCQNGRDYVVTKQPSVCPCSLEDFLCDFGYFRPENDSKCVEQPELKGHDLEF 642

Query: 2158 CLYGREEHLTTNGYRKIPGDRCQGGVNPAREVKDLKKKCTSNFLSPEKQDSRPQGHNLSQ 2337
            CLYGREEHLTTNGYRKIPGDRCQGGVNPAREVKDLKKKCTSNFLSPE             
Sbjct: 643  CLYGREEHLTTNGYRKIPGDRCQGGVNPAREVKDLKKKCTSNFLSPE------------- 689

Query: 2338 NPAPPPLGYTENTHSLSPTQKQNSKSSSVPIILATVGLMLVTVVAGVLIVKKYVCGGRF 2514
                                KQNSKSSSVPIILATVGLMLVTVVAGVLIVKKYVCGGRF
Sbjct: 690  --------------------KQNSKSSSVPIILATVGLMLVTVVAGVLIVKKYVCGGRF 728



 Score = 58.5 bits (140), Expect(2) = 2e-14
 Identities = 28/35 (80%), Positives = 30/35 (85%)
 Frame = +3

Query: 2505 GKVLVHRYSVLQQHAEANGVDGVDALDTPSTPLKA 2609
            G+ LVHRYSVLQQHAEANGVDGVDALDT S   K+
Sbjct: 726  GRFLVHRYSVLQQHAEANGVDGVDALDTASHTTKS 760



 Score = 39.7 bits (91), Expect(2) = 2e-14
 Identities = 17/18 (94%), Positives = 17/18 (94%)
 Frame = +2

Query: 2588 ALHTTKSGYHDDSDEDLL 2641
            A HTTKSGYHDDSDEDLL
Sbjct: 754  ASHTTKSGYHDDSDEDLL 771


>ref|XP_003359412.1| PREDICTED: VPS10 domain-containing receptor SorCS1 [Sus scrofa].
          Length = 1187

 Score =  226 bits (577), Expect = 4e-59
 Identities = 171/691 (24%), Positives = 320/691 (46%), Gaps = 25/691 (3%)
 Frame = +1

Query: 337  RLANNTHQHVFDDLSGSVSLSWVGDSTGIILVLTTFHVPLVIMTFGQSKLYRSEDYGKNF 516
            RL + T     D       + W G ++ +IL+LT  +    + +  +S L+RS DYG  +
Sbjct: 159  RLTSTTFALTGDSAHNQAMVHWSGHNSSVILILTKLY-DYNLGSITESSLWRSTDYGTTY 217

Query: 517  KDITNLINNTFIRTEFGMAIGPENSGKVILTAEVSGGSHGGRIFRSSDFAKNFIQTNLPF 696
            + + + +    I +   + + P N  K++L  +    S    +  SSD    + +  L F
Sbjct: 218  EKLNDKVGLKTILSY--LYVCPTNKRKIMLLTDPEIESS---LLISSDEGATYQKYRLNF 272

Query: 697  HPLTQMMYSPQNSDHLLALSTENGLWVSKNFGGKWEEIHKAVCLAKWGSDSTIFFTTYVN 876
            + +  +++ P+  D +LA S +  L+ S  FG +W+ I + V   +       F+ + + 
Sbjct: 273  Y-IQSLLFHPKQEDWILAYSQDQKLYSSAEFGRRWQLIQEGVVPNR-------FYWSVMG 324

Query: 877  GSCKADLGALELRRTSDLGKSFKTIGVKIYSFGLGGRFLFASVMADKDTTRRIHVSTD-- 1050
             + + DL  LE R T D    + T  ++  +     +     +  D    +  +V     
Sbjct: 325  SNKEPDLVHLEAR-TVDGHSQYLTCRMQNCTEANRNKPFPGYIDPDSLIVQDDYVFVQLT 383

Query: 1051 -----------QGDTWSMAQLPSVGQEQFYSILAANDDMVFMHVDEPGDTGFGTIFTSDD 1197
                       + +T++  +LP     +   +++ +++ VF  V E        ++ SD 
Sbjct: 384  SGGRPHYYVSYRRNTFAQMKLPKYALPKDMHVISTDENQVFAAVQEWNQNDTYNLYISDT 443

Query: 1198 RGIVYSKSLDRHLYTTTGGE----TDFTNVTSLRGVYMTSVLSEDNSIQTMITFDQGGRW 1365
            RG+ ++ +L+ ++ ++ G E     D   V  ++G+++ +    DN ++T IT+++G  W
Sbjct: 444  RGVYFTLALE-NVQSSRGPEGNVMIDLYEVAGIKGMFLANK-KIDNQVKTFITYNKGRDW 501

Query: 1366 KHLRKPENS-ECDATAKNKNECSLHIHASYSISQKLNVPMAPLSEPNAVGIVIAHGSVGD 1542
            + L+ P+     D        CSLH+H   S +   +  +A  S   A  I++A G++G 
Sbjct: 502  RLLQAPDTDLRGDPVHCLLPYCSLHLHLKVSENPYTSGIIA--SRDTAPSIIVASGNIGS 559

Query: 1543 AISVMIPDVYISDDGGYSWLKMLEGPHYYTILDSGGIIVAIEHSSHPINVIKFSTDEGQC 1722
             +S     +++S D G +W ++ E  H    LD GG++VA++H+S PI  +  S DEG+ 
Sbjct: 560  ELSDSDISMFVSSDAGNTWRQIFEEEHSVLYLDQGGVLVAMKHTSLPIRHLWLSFDEGRS 619

Query: 1723 WQTYVFSREPIYFTGLASEPGARSMNISIWGFTESFLTRQWVSYTIDFKDILERNCEEKD 1902
            W  Y F+  P++  G+  EPG  ++ ++++G        +W    +D+K I +R C E+D
Sbjct: 620  WSKYSFTSIPLFVDGVLGEPGEETLIMTVFGHFSH--RSEWQLVKVDYKSIFDRRCAEED 677

Query: 1903 YTVWLAHSTDPGDYGDGCILGYKEQYLRLRKSSVCQNGRDYVVTKQPSVCPCSLEDFLCD 2082
            Y  W  HS      G+ CI+G K  Y + +    C  G+ Y    +   C C+  DF CD
Sbjct: 678  YRPWQLHS-----QGEACIMGAKRIYKKRKSERKCMQGK-YAGAMESEPCVCTEADFDCD 731

Query: 2083 FGYFRPENDSKCVEQPELKGHDL-EFCLYGREEHLTTNGYRKIPGDRCQGGVNPAREVKD 2259
            +GY R  N  +C+         L + C  G + +L + GYRK+  + C  GV      K 
Sbjct: 732  YGYERHSN-GQCLPAFWFNPSSLSKDCSLG-QSYLNSTGYRKVVSNNCTDGVREQYTAK- 788

Query: 2260 LKKKCTS------NFLSPEKQDSRPQGHNLS 2334
              +KC          ++ + + +  QGHN++
Sbjct: 789  -PQKCPGKAPRGLRIVTADGKLTAEQGHNVT 818


>ref|XP_003359411.1| PREDICTED: VPS10 domain-containing receptor SorCS1 [Sus scrofa].
          Length = 1179

 Score =  226 bits (577), Expect = 4e-59
 Identities = 171/691 (24%), Positives = 320/691 (46%), Gaps = 25/691 (3%)
 Frame = +1

Query: 337  RLANNTHQHVFDDLSGSVSLSWVGDSTGIILVLTTFHVPLVIMTFGQSKLYRSEDYGKNF 516
            RL + T     D       + W G ++ +IL+LT  +    + +  +S L+RS DYG  +
Sbjct: 159  RLTSTTFALTGDSAHNQAMVHWSGHNSSVILILTKLY-DYNLGSITESSLWRSTDYGTTY 217

Query: 517  KDITNLINNTFIRTEFGMAIGPENSGKVILTAEVSGGSHGGRIFRSSDFAKNFIQTNLPF 696
            + + + +    I +   + + P N  K++L  +    S    +  SSD    + +  L F
Sbjct: 218  EKLNDKVGLKTILSY--LYVCPTNKRKIMLLTDPEIESS---LLISSDEGATYQKYRLNF 272

Query: 697  HPLTQMMYSPQNSDHLLALSTENGLWVSKNFGGKWEEIHKAVCLAKWGSDSTIFFTTYVN 876
            + +  +++ P+  D +LA S +  L+ S  FG +W+ I + V   +       F+ + + 
Sbjct: 273  Y-IQSLLFHPKQEDWILAYSQDQKLYSSAEFGRRWQLIQEGVVPNR-------FYWSVMG 324

Query: 877  GSCKADLGALELRRTSDLGKSFKTIGVKIYSFGLGGRFLFASVMADKDTTRRIHVSTD-- 1050
             + + DL  LE R T D    + T  ++  +     +     +  D    +  +V     
Sbjct: 325  SNKEPDLVHLEAR-TVDGHSQYLTCRMQNCTEANRNKPFPGYIDPDSLIVQDDYVFVQLT 383

Query: 1051 -----------QGDTWSMAQLPSVGQEQFYSILAANDDMVFMHVDEPGDTGFGTIFTSDD 1197
                       + +T++  +LP     +   +++ +++ VF  V E        ++ SD 
Sbjct: 384  SGGRPHYYVSYRRNTFAQMKLPKYALPKDMHVISTDENQVFAAVQEWNQNDTYNLYISDT 443

Query: 1198 RGIVYSKSLDRHLYTTTGGE----TDFTNVTSLRGVYMTSVLSEDNSIQTMITFDQGGRW 1365
            RG+ ++ +L+ ++ ++ G E     D   V  ++G+++ +    DN ++T IT+++G  W
Sbjct: 444  RGVYFTLALE-NVQSSRGPEGNVMIDLYEVAGIKGMFLANK-KIDNQVKTFITYNKGRDW 501

Query: 1366 KHLRKPENS-ECDATAKNKNECSLHIHASYSISQKLNVPMAPLSEPNAVGIVIAHGSVGD 1542
            + L+ P+     D        CSLH+H   S +   +  +A  S   A  I++A G++G 
Sbjct: 502  RLLQAPDTDLRGDPVHCLLPYCSLHLHLKVSENPYTSGIIA--SRDTAPSIIVASGNIGS 559

Query: 1543 AISVMIPDVYISDDGGYSWLKMLEGPHYYTILDSGGIIVAIEHSSHPINVIKFSTDEGQC 1722
             +S     +++S D G +W ++ E  H    LD GG++VA++H+S PI  +  S DEG+ 
Sbjct: 560  ELSDSDISMFVSSDAGNTWRQIFEEEHSVLYLDQGGVLVAMKHTSLPIRHLWLSFDEGRS 619

Query: 1723 WQTYVFSREPIYFTGLASEPGARSMNISIWGFTESFLTRQWVSYTIDFKDILERNCEEKD 1902
            W  Y F+  P++  G+  EPG  ++ ++++G        +W    +D+K I +R C E+D
Sbjct: 620  WSKYSFTSIPLFVDGVLGEPGEETLIMTVFGHFSH--RSEWQLVKVDYKSIFDRRCAEED 677

Query: 1903 YTVWLAHSTDPGDYGDGCILGYKEQYLRLRKSSVCQNGRDYVVTKQPSVCPCSLEDFLCD 2082
            Y  W  HS      G+ CI+G K  Y + +    C  G+ Y    +   C C+  DF CD
Sbjct: 678  YRPWQLHS-----QGEACIMGAKRIYKKRKSERKCMQGK-YAGAMESEPCVCTEADFDCD 731

Query: 2083 FGYFRPENDSKCVEQPELKGHDL-EFCLYGREEHLTTNGYRKIPGDRCQGGVNPAREVKD 2259
            +GY R  N  +C+         L + C  G + +L + GYRK+  + C  GV      K 
Sbjct: 732  YGYERHSN-GQCLPAFWFNPSSLSKDCSLG-QSYLNSTGYRKVVSNNCTDGVREQYTAK- 788

Query: 2260 LKKKCTS------NFLSPEKQDSRPQGHNLS 2334
              +KC          ++ + + +  QGHN++
Sbjct: 789  -PQKCPGKAPRGLRIVTADGKLTAEQGHNVT 818


>ref|XP_001924753.1| PREDICTED: VPS10 domain-containing receptor SorCS1 isoform 2 [Sus
            scrofa].
          Length = 1198

 Score =  226 bits (577), Expect = 4e-59
 Identities = 171/691 (24%), Positives = 320/691 (46%), Gaps = 25/691 (3%)
 Frame = +1

Query: 337  RLANNTHQHVFDDLSGSVSLSWVGDSTGIILVLTTFHVPLVIMTFGQSKLYRSEDYGKNF 516
            RL + T     D       + W G ++ +IL+LT  +    + +  +S L+RS DYG  +
Sbjct: 159  RLTSTTFALTGDSAHNQAMVHWSGHNSSVILILTKLY-DYNLGSITESSLWRSTDYGTTY 217

Query: 517  KDITNLINNTFIRTEFGMAIGPENSGKVILTAEVSGGSHGGRIFRSSDFAKNFIQTNLPF 696
            + + + +    I +   + + P N  K++L  +    S    +  SSD    + +  L F
Sbjct: 218  EKLNDKVGLKTILSY--LYVCPTNKRKIMLLTDPEIESS---LLISSDEGATYQKYRLNF 272

Query: 697  HPLTQMMYSPQNSDHLLALSTENGLWVSKNFGGKWEEIHKAVCLAKWGSDSTIFFTTYVN 876
            + +  +++ P+  D +LA S +  L+ S  FG +W+ I + V   +       F+ + + 
Sbjct: 273  Y-IQSLLFHPKQEDWILAYSQDQKLYSSAEFGRRWQLIQEGVVPNR-------FYWSVMG 324

Query: 877  GSCKADLGALELRRTSDLGKSFKTIGVKIYSFGLGGRFLFASVMADKDTTRRIHVSTD-- 1050
             + + DL  LE R T D    + T  ++  +     +     +  D    +  +V     
Sbjct: 325  SNKEPDLVHLEAR-TVDGHSQYLTCRMQNCTEANRNKPFPGYIDPDSLIVQDDYVFVQLT 383

Query: 1051 -----------QGDTWSMAQLPSVGQEQFYSILAANDDMVFMHVDEPGDTGFGTIFTSDD 1197
                       + +T++  +LP     +   +++ +++ VF  V E        ++ SD 
Sbjct: 384  SGGRPHYYVSYRRNTFAQMKLPKYALPKDMHVISTDENQVFAAVQEWNQNDTYNLYISDT 443

Query: 1198 RGIVYSKSLDRHLYTTTGGE----TDFTNVTSLRGVYMTSVLSEDNSIQTMITFDQGGRW 1365
            RG+ ++ +L+ ++ ++ G E     D   V  ++G+++ +    DN ++T IT+++G  W
Sbjct: 444  RGVYFTLALE-NVQSSRGPEGNVMIDLYEVAGIKGMFLANK-KIDNQVKTFITYNKGRDW 501

Query: 1366 KHLRKPENS-ECDATAKNKNECSLHIHASYSISQKLNVPMAPLSEPNAVGIVIAHGSVGD 1542
            + L+ P+     D        CSLH+H   S +   +  +A  S   A  I++A G++G 
Sbjct: 502  RLLQAPDTDLRGDPVHCLLPYCSLHLHLKVSENPYTSGIIA--SRDTAPSIIVASGNIGS 559

Query: 1543 AISVMIPDVYISDDGGYSWLKMLEGPHYYTILDSGGIIVAIEHSSHPINVIKFSTDEGQC 1722
             +S     +++S D G +W ++ E  H    LD GG++VA++H+S PI  +  S DEG+ 
Sbjct: 560  ELSDSDISMFVSSDAGNTWRQIFEEEHSVLYLDQGGVLVAMKHTSLPIRHLWLSFDEGRS 619

Query: 1723 WQTYVFSREPIYFTGLASEPGARSMNISIWGFTESFLTRQWVSYTIDFKDILERNCEEKD 1902
            W  Y F+  P++  G+  EPG  ++ ++++G        +W    +D+K I +R C E+D
Sbjct: 620  WSKYSFTSIPLFVDGVLGEPGEETLIMTVFGHFSH--RSEWQLVKVDYKSIFDRRCAEED 677

Query: 1903 YTVWLAHSTDPGDYGDGCILGYKEQYLRLRKSSVCQNGRDYVVTKQPSVCPCSLEDFLCD 2082
            Y  W  HS      G+ CI+G K  Y + +    C  G+ Y    +   C C+  DF CD
Sbjct: 678  YRPWQLHS-----QGEACIMGAKRIYKKRKSERKCMQGK-YAGAMESEPCVCTEADFDCD 731

Query: 2083 FGYFRPENDSKCVEQPELKGHDL-EFCLYGREEHLTTNGYRKIPGDRCQGGVNPAREVKD 2259
            +GY R  N  +C+         L + C  G + +L + GYRK+  + C  GV      K 
Sbjct: 732  YGYERHSN-GQCLPAFWFNPSSLSKDCSLG-QSYLNSTGYRKVVSNNCTDGVREQYTAK- 788

Query: 2260 LKKKCTS------NFLSPEKQDSRPQGHNLS 2334
              +KC          ++ + + +  QGHN++
Sbjct: 789  -PQKCPGKAPRGLRIVTADGKLTAEQGHNVT 818


>ref|XP_003359410.1| PREDICTED: VPS10 domain-containing receptor SorCS1 [Sus scrofa].
          Length = 1130

 Score =  226 bits (577), Expect = 4e-59
 Identities = 171/691 (24%), Positives = 320/691 (46%), Gaps = 25/691 (3%)
 Frame = +1

Query: 337  RLANNTHQHVFDDLSGSVSLSWVGDSTGIILVLTTFHVPLVIMTFGQSKLYRSEDYGKNF 516
            RL + T     D       + W G ++ +IL+LT  +    + +  +S L+RS DYG  +
Sbjct: 159  RLTSTTFALTGDSAHNQAMVHWSGHNSSVILILTKLY-DYNLGSITESSLWRSTDYGTTY 217

Query: 517  KDITNLINNTFIRTEFGMAIGPENSGKVILTAEVSGGSHGGRIFRSSDFAKNFIQTNLPF 696
            + + + +    I +   + + P N  K++L  +    S    +  SSD    + +  L F
Sbjct: 218  EKLNDKVGLKTILSY--LYVCPTNKRKIMLLTDPEIESS---LLISSDEGATYQKYRLNF 272

Query: 697  HPLTQMMYSPQNSDHLLALSTENGLWVSKNFGGKWEEIHKAVCLAKWGSDSTIFFTTYVN 876
            + +  +++ P+  D +LA S +  L+ S  FG +W+ I + V   +       F+ + + 
Sbjct: 273  Y-IQSLLFHPKQEDWILAYSQDQKLYSSAEFGRRWQLIQEGVVPNR-------FYWSVMG 324

Query: 877  GSCKADLGALELRRTSDLGKSFKTIGVKIYSFGLGGRFLFASVMADKDTTRRIHVSTD-- 1050
             + + DL  LE R T D    + T  ++  +     +     +  D    +  +V     
Sbjct: 325  SNKEPDLVHLEAR-TVDGHSQYLTCRMQNCTEANRNKPFPGYIDPDSLIVQDDYVFVQLT 383

Query: 1051 -----------QGDTWSMAQLPSVGQEQFYSILAANDDMVFMHVDEPGDTGFGTIFTSDD 1197
                       + +T++  +LP     +   +++ +++ VF  V E        ++ SD 
Sbjct: 384  SGGRPHYYVSYRRNTFAQMKLPKYALPKDMHVISTDENQVFAAVQEWNQNDTYNLYISDT 443

Query: 1198 RGIVYSKSLDRHLYTTTGGE----TDFTNVTSLRGVYMTSVLSEDNSIQTMITFDQGGRW 1365
            RG+ ++ +L+ ++ ++ G E     D   V  ++G+++ +    DN ++T IT+++G  W
Sbjct: 444  RGVYFTLALE-NVQSSRGPEGNVMIDLYEVAGIKGMFLANK-KIDNQVKTFITYNKGRDW 501

Query: 1366 KHLRKPENS-ECDATAKNKNECSLHIHASYSISQKLNVPMAPLSEPNAVGIVIAHGSVGD 1542
            + L+ P+     D        CSLH+H   S +   +  +A  S   A  I++A G++G 
Sbjct: 502  RLLQAPDTDLRGDPVHCLLPYCSLHLHLKVSENPYTSGIIA--SRDTAPSIIVASGNIGS 559

Query: 1543 AISVMIPDVYISDDGGYSWLKMLEGPHYYTILDSGGIIVAIEHSSHPINVIKFSTDEGQC 1722
             +S     +++S D G +W ++ E  H    LD GG++VA++H+S PI  +  S DEG+ 
Sbjct: 560  ELSDSDISMFVSSDAGNTWRQIFEEEHSVLYLDQGGVLVAMKHTSLPIRHLWLSFDEGRS 619

Query: 1723 WQTYVFSREPIYFTGLASEPGARSMNISIWGFTESFLTRQWVSYTIDFKDILERNCEEKD 1902
            W  Y F+  P++  G+  EPG  ++ ++++G        +W    +D+K I +R C E+D
Sbjct: 620  WSKYSFTSIPLFVDGVLGEPGEETLIMTVFGHFSH--RSEWQLVKVDYKSIFDRRCAEED 677

Query: 1903 YTVWLAHSTDPGDYGDGCILGYKEQYLRLRKSSVCQNGRDYVVTKQPSVCPCSLEDFLCD 2082
            Y  W  HS      G+ CI+G K  Y + +    C  G+ Y    +   C C+  DF CD
Sbjct: 678  YRPWQLHS-----QGEACIMGAKRIYKKRKSERKCMQGK-YAGAMESEPCVCTEADFDCD 731

Query: 2083 FGYFRPENDSKCVEQPELKGHDL-EFCLYGREEHLTTNGYRKIPGDRCQGGVNPAREVKD 2259
            +GY R  N  +C+         L + C  G + +L + GYRK+  + C  GV      K 
Sbjct: 732  YGYERHSN-GQCLPAFWFNPSSLSKDCSLG-QSYLNSTGYRKVVSNNCTDGVREQYTAK- 788

Query: 2260 LKKKCTS------NFLSPEKQDSRPQGHNLS 2334
              +KC          ++ + + +  QGHN++
Sbjct: 789  -PQKCPGKAPRGLRIVTADGKLTAEQGHNVT 818


>ref|XP_001924739.1| PREDICTED: VPS10 domain-containing receptor SorCS1 isoform 1 [Sus
            scrofa].
          Length = 1168

 Score =  226 bits (577), Expect = 4e-59
 Identities = 171/691 (24%), Positives = 320/691 (46%), Gaps = 25/691 (3%)
 Frame = +1

Query: 337  RLANNTHQHVFDDLSGSVSLSWVGDSTGIILVLTTFHVPLVIMTFGQSKLYRSEDYGKNF 516
            RL + T     D       + W G ++ +IL+LT  +    + +  +S L+RS DYG  +
Sbjct: 159  RLTSTTFALTGDSAHNQAMVHWSGHNSSVILILTKLY-DYNLGSITESSLWRSTDYGTTY 217

Query: 517  KDITNLINNTFIRTEFGMAIGPENSGKVILTAEVSGGSHGGRIFRSSDFAKNFIQTNLPF 696
            + + + +    I +   + + P N  K++L  +    S    +  SSD    + +  L F
Sbjct: 218  EKLNDKVGLKTILSY--LYVCPTNKRKIMLLTDPEIESS---LLISSDEGATYQKYRLNF 272

Query: 697  HPLTQMMYSPQNSDHLLALSTENGLWVSKNFGGKWEEIHKAVCLAKWGSDSTIFFTTYVN 876
            + +  +++ P+  D +LA S +  L+ S  FG +W+ I + V   +       F+ + + 
Sbjct: 273  Y-IQSLLFHPKQEDWILAYSQDQKLYSSAEFGRRWQLIQEGVVPNR-------FYWSVMG 324

Query: 877  GSCKADLGALELRRTSDLGKSFKTIGVKIYSFGLGGRFLFASVMADKDTTRRIHVSTD-- 1050
             + + DL  LE R T D    + T  ++  +     +     +  D    +  +V     
Sbjct: 325  SNKEPDLVHLEAR-TVDGHSQYLTCRMQNCTEANRNKPFPGYIDPDSLIVQDDYVFVQLT 383

Query: 1051 -----------QGDTWSMAQLPSVGQEQFYSILAANDDMVFMHVDEPGDTGFGTIFTSDD 1197
                       + +T++  +LP     +   +++ +++ VF  V E        ++ SD 
Sbjct: 384  SGGRPHYYVSYRRNTFAQMKLPKYALPKDMHVISTDENQVFAAVQEWNQNDTYNLYISDT 443

Query: 1198 RGIVYSKSLDRHLYTTTGGE----TDFTNVTSLRGVYMTSVLSEDNSIQTMITFDQGGRW 1365
            RG+ ++ +L+ ++ ++ G E     D   V  ++G+++ +    DN ++T IT+++G  W
Sbjct: 444  RGVYFTLALE-NVQSSRGPEGNVMIDLYEVAGIKGMFLANK-KIDNQVKTFITYNKGRDW 501

Query: 1366 KHLRKPENS-ECDATAKNKNECSLHIHASYSISQKLNVPMAPLSEPNAVGIVIAHGSVGD 1542
            + L+ P+     D        CSLH+H   S +   +  +A  S   A  I++A G++G 
Sbjct: 502  RLLQAPDTDLRGDPVHCLLPYCSLHLHLKVSENPYTSGIIA--SRDTAPSIIVASGNIGS 559

Query: 1543 AISVMIPDVYISDDGGYSWLKMLEGPHYYTILDSGGIIVAIEHSSHPINVIKFSTDEGQC 1722
             +S     +++S D G +W ++ E  H    LD GG++VA++H+S PI  +  S DEG+ 
Sbjct: 560  ELSDSDISMFVSSDAGNTWRQIFEEEHSVLYLDQGGVLVAMKHTSLPIRHLWLSFDEGRS 619

Query: 1723 WQTYVFSREPIYFTGLASEPGARSMNISIWGFTESFLTRQWVSYTIDFKDILERNCEEKD 1902
            W  Y F+  P++  G+  EPG  ++ ++++G        +W    +D+K I +R C E+D
Sbjct: 620  WSKYSFTSIPLFVDGVLGEPGEETLIMTVFGHFSH--RSEWQLVKVDYKSIFDRRCAEED 677

Query: 1903 YTVWLAHSTDPGDYGDGCILGYKEQYLRLRKSSVCQNGRDYVVTKQPSVCPCSLEDFLCD 2082
            Y  W  HS      G+ CI+G K  Y + +    C  G+ Y    +   C C+  DF CD
Sbjct: 678  YRPWQLHS-----QGEACIMGAKRIYKKRKSERKCMQGK-YAGAMESEPCVCTEADFDCD 731

Query: 2083 FGYFRPENDSKCVEQPELKGHDL-EFCLYGREEHLTTNGYRKIPGDRCQGGVNPAREVKD 2259
            +GY R  N  +C+         L + C  G + +L + GYRK+  + C  GV      K 
Sbjct: 732  YGYERHSN-GQCLPAFWFNPSSLSKDCSLG-QSYLNSTGYRKVVSNNCTDGVREQYTAK- 788

Query: 2260 LKKKCTS------NFLSPEKQDSRPQGHNLS 2334
              +KC          ++ + + +  QGHN++
Sbjct: 789  -PQKCPGKAPRGLRIVTADGKLTAEQGHNVT 818


>ref|XP_003359409.1| PREDICTED: VPS10 domain-containing receptor SorCS1 [Sus scrofa].
          Length = 1179

 Score =  226 bits (577), Expect = 4e-59
 Identities = 171/691 (24%), Positives = 320/691 (46%), Gaps = 25/691 (3%)
 Frame = +1

Query: 337  RLANNTHQHVFDDLSGSVSLSWVGDSTGIILVLTTFHVPLVIMTFGQSKLYRSEDYGKNF 516
            RL + T     D       + W G ++ +IL+LT  +    + +  +S L+RS DYG  +
Sbjct: 159  RLTSTTFALTGDSAHNQAMVHWSGHNSSVILILTKLY-DYNLGSITESSLWRSTDYGTTY 217

Query: 517  KDITNLINNTFIRTEFGMAIGPENSGKVILTAEVSGGSHGGRIFRSSDFAKNFIQTNLPF 696
            + + + +    I +   + + P N  K++L  +    S    +  SSD    + +  L F
Sbjct: 218  EKLNDKVGLKTILSY--LYVCPTNKRKIMLLTDPEIESS---LLISSDEGATYQKYRLNF 272

Query: 697  HPLTQMMYSPQNSDHLLALSTENGLWVSKNFGGKWEEIHKAVCLAKWGSDSTIFFTTYVN 876
            + +  +++ P+  D +LA S +  L+ S  FG +W+ I + V   +       F+ + + 
Sbjct: 273  Y-IQSLLFHPKQEDWILAYSQDQKLYSSAEFGRRWQLIQEGVVPNR-------FYWSVMG 324

Query: 877  GSCKADLGALELRRTSDLGKSFKTIGVKIYSFGLGGRFLFASVMADKDTTRRIHVSTD-- 1050
             + + DL  LE R T D    + T  ++  +     +     +  D    +  +V     
Sbjct: 325  SNKEPDLVHLEAR-TVDGHSQYLTCRMQNCTEANRNKPFPGYIDPDSLIVQDDYVFVQLT 383

Query: 1051 -----------QGDTWSMAQLPSVGQEQFYSILAANDDMVFMHVDEPGDTGFGTIFTSDD 1197
                       + +T++  +LP     +   +++ +++ VF  V E        ++ SD 
Sbjct: 384  SGGRPHYYVSYRRNTFAQMKLPKYALPKDMHVISTDENQVFAAVQEWNQNDTYNLYISDT 443

Query: 1198 RGIVYSKSLDRHLYTTTGGE----TDFTNVTSLRGVYMTSVLSEDNSIQTMITFDQGGRW 1365
            RG+ ++ +L+ ++ ++ G E     D   V  ++G+++ +    DN ++T IT+++G  W
Sbjct: 444  RGVYFTLALE-NVQSSRGPEGNVMIDLYEVAGIKGMFLANK-KIDNQVKTFITYNKGRDW 501

Query: 1366 KHLRKPENS-ECDATAKNKNECSLHIHASYSISQKLNVPMAPLSEPNAVGIVIAHGSVGD 1542
            + L+ P+     D        CSLH+H   S +   +  +A  S   A  I++A G++G 
Sbjct: 502  RLLQAPDTDLRGDPVHCLLPYCSLHLHLKVSENPYTSGIIA--SRDTAPSIIVASGNIGS 559

Query: 1543 AISVMIPDVYISDDGGYSWLKMLEGPHYYTILDSGGIIVAIEHSSHPINVIKFSTDEGQC 1722
             +S     +++S D G +W ++ E  H    LD GG++VA++H+S PI  +  S DEG+ 
Sbjct: 560  ELSDSDISMFVSSDAGNTWRQIFEEEHSVLYLDQGGVLVAMKHTSLPIRHLWLSFDEGRS 619

Query: 1723 WQTYVFSREPIYFTGLASEPGARSMNISIWGFTESFLTRQWVSYTIDFKDILERNCEEKD 1902
            W  Y F+  P++  G+  EPG  ++ ++++G        +W    +D+K I +R C E+D
Sbjct: 620  WSKYSFTSIPLFVDGVLGEPGEETLIMTVFGHFSH--RSEWQLVKVDYKSIFDRRCAEED 677

Query: 1903 YTVWLAHSTDPGDYGDGCILGYKEQYLRLRKSSVCQNGRDYVVTKQPSVCPCSLEDFLCD 2082
            Y  W  HS      G+ CI+G K  Y + +    C  G+ Y    +   C C+  DF CD
Sbjct: 678  YRPWQLHS-----QGEACIMGAKRIYKKRKSERKCMQGK-YAGAMESEPCVCTEADFDCD 731

Query: 2083 FGYFRPENDSKCVEQPELKGHDL-EFCLYGREEHLTTNGYRKIPGDRCQGGVNPAREVKD 2259
            +GY R  N  +C+         L + C  G + +L + GYRK+  + C  GV      K 
Sbjct: 732  YGYERHSN-GQCLPAFWFNPSSLSKDCSLG-QSYLNSTGYRKVVSNNCTDGVREQYTAK- 788

Query: 2260 LKKKCTS------NFLSPEKQDSRPQGHNLS 2334
              +KC          ++ + + +  QGHN++
Sbjct: 789  -PQKCPGKAPRGLRIVTADGKLTAEQGHNVT 818


>ref|XP_003133227.2| PREDICTED: VPS10 domain-containing receptor SorCS3 [Sus scrofa].
          Length = 1222

 Score =  204 bits (518), Expect = 3e-52
 Identities = 161/663 (24%), Positives = 315/663 (47%), Gaps = 22/663 (3%)
 Frame = +1

Query: 313  GGVRDFVARLANNTHQHVFDDLSGSVSLSWVGDSTGIILVLTTFHVPLVIMTFGQSKLYR 492
            GG+     RL + +     D       + W G ++ +IL+LT  +    + +  +S L+R
Sbjct: 174  GGLAAEELRLPSTSFALTGDSAHNQAMVHWSGHNSSVILILTKLY-DFNLGSVTESSLWR 232

Query: 493  SEDYGKNFKDITNLINNTFIRTEFGMAIGPENSGKVILTAEVSGGSHGGRIFRSSDFAKN 672
            S DYG  ++ + + +    + +   + + P N  K++L ++    S    I  SSD    
Sbjct: 233  STDYGTTYEKLNDKVGLKTVLSY--LYVNPTNKRKIMLLSDPEMESS---ILISSDEGAT 287

Query: 673  FIQTNLPFHPLTQMMYSPQNSDHLLALSTENGLWVSKNFGGKWEEIHKAVCLAKWGSDST 852
            + +  L F+ +  +++ P+  D +LA S +  L+ S +FG +W+ +H+ +   +      
Sbjct: 288  YQKYRLTFY-IQSLLFHPKQEDWVLAYSLDQKLYSSMDFGRRWQLMHERITPNR------ 340

Query: 853  IFFTTYVNGSCKADLGALELRRTSDLGKSFKTIGVKIYS----FGLGGRFLFASVMADKD 1020
             F+ +      +ADL  +E+R T+D    + T  ++  +     G   R +  S +  +D
Sbjct: 341  -FYWSVAGLDKEADLVHMEVR-TADGYAHYLTCRIQECAETTRSGPFARSIDISSLVVQD 398

Query: 1021 TTRRIHVSTD---------QGDTWSMAQLPSVGQEQFYSILAANDDMVFMHVDEPGDTGF 1173
                I V+T          + + ++  +LP     +   I++ +++ VF  V E      
Sbjct: 399  EYIFIQVTTGGRASYYVSYRREAFAQIKLPKYSLPKDMHIISTDENQVFAAVQEWNQNDT 458

Query: 1174 GTIFTSDDRGIVYSKSLDRHLYTTTG--GET--DFTNVTSLRGVYMTSVLSEDNSIQTMI 1341
              ++ SD RGI ++ +++ ++ ++ G  G    +   V  ++G+++ +    D+ ++T I
Sbjct: 459  YNLYISDTRGIYFTLAME-NIKSSRGLMGNIVIELYEVAGIKGIFLANK-KVDDQVKTYI 516

Query: 1342 TFDQGGRWKHLRKPENSECDATAKNKNE-CSLHIHASYSISQKLNVPMAPLSEPNAVGIV 1518
            T+++G  W+ L+ P+     +        CSLH+H   S +   +  ++  S+  A G+V
Sbjct: 517  TYNKGRDWRLLQAPDVDLRGSPVHCLLPFCSLHLHLQISENPYSSGRIS--SKETAPGLV 574

Query: 1519 IAHGSVGDAISVMIPDVYISDDGGYSWLKMLEGPHYYTILDSGGIIVAIEHSSHPINVIK 1698
            +A G++G  +S     V+IS DGG +W ++ +  +    LD GG +VA++H+  P+  + 
Sbjct: 575  VATGNIGPELSYTDISVFISSDGGNTWRQIFDEEYNVWFLDWGGALVAMKHTPLPVRHLW 634

Query: 1699 FSTDEGQCWQTYVFSREPIYFTGLASEPGARSMNISIWGFTESFLTRQWVSYTIDFKDIL 1878
             S DEG  W  Y F+  P++  G   E G  +  ++++G     L  +W    +D+K I 
Sbjct: 635  VSFDEGHSWDKYGFTSLPLFVDGALVEAGVETQIMTVFGHFS--LRSEWQLVKVDYKSIF 692

Query: 1879 ERNCEEKDYTVWLAHSTDPGDYGDGCILGYKEQYLRLRKSSVCQNGRDYVVTKQPSVCPC 2058
             R C ++D+  W  H     + G+ C++G ++ + + +  + C   RD   T     C C
Sbjct: 693  SRRCNKEDFQTW--HLL---NQGEPCVMGERKIFKKRKPGAQCALSRDASGTVVSEPCVC 747

Query: 2059 SLEDFLCDFGYFRPENDSKCVE----QPELKGHDLEFCLYGREEHLTTNGYRKIPGDRCQ 2226
            +  DF CD+GY R   +S+CV      P     D   C  G + +L + GYR+I  + C 
Sbjct: 748  ADWDFECDYGYER-HGESQCVPAFWYNPASPSKD---CSLG-QSYLNSTGYRRIVSNNCT 802

Query: 2227 GGV 2235
             G+
Sbjct: 803  DGL 805


>ref|XP_003356901.1| PREDICTED: VPS10 domain-containing receptor SorCS2 [Sus scrofa].
          Length = 835

 Score =  193 bits (490), Expect = 5e-49
 Identities = 121/440 (27%), Positives = 219/440 (49%), Gaps = 14/440 (3%)
 Frame = +1

Query: 988  FLFASVMADKDTTRRIHVSTDQGDTWSMAQLPSVGQEQFYSILAANDDMVFMHVDEPGDT 1167
            F+F  V   +   R I++S  + + + + +LP     +   +++ ++  VF+ V E   T
Sbjct: 156  FIFFKVSTHQ---RPIYISYRRNE-FVLMKLPKYALPKDLQVVSTDESQVFVAVQEWYQT 211

Query: 1168 GFGTIFTSDDRGIVYSKSLDRHLYTTTGGETDFTNVTSLRGVYMTSVLSE--DNSIQTMI 1341
                ++ SD RG  YS  L+    +    E+   ++  +RGV    + ++  D  + T+I
Sbjct: 212  DTYNLYQSDPRGERYSLVLEDVRSSRQAEESTVVDILEVRGVKGVFLANQKVDGKVVTLI 271

Query: 1342 TFDQGGRWKHLRKPENSECDATAKNKN----ECSLHIHASYSISQKLNVPMAPLSEPNAV 1509
            T+++G  W  LR P     D + K  N    +C LH+H  ++ +  ++  +   ++  A 
Sbjct: 272  TYNKGRDWDRLRPPS---VDMSGKPTNCKPPDCHLHLHLRWADNPYVSGTVH--TKDTAP 326

Query: 1510 GIVIAHGSVGDAISVMIPDVYISDDGGYSWLKMLEGPHYYTILDSGGIIVAIEHSSHPIN 1689
            G+++  G++G  +     ++YI+ D G++W ++ E  H+   LD GG+IVAI+ +S P+ 
Sbjct: 327  GLIMGAGNLGSQLVEYKEEMYITSDCGHTWRQVFEEEHHILYLDHGGVIVAIKDTSIPLK 386

Query: 1690 VIKFSTDEGQCWQTYVFSREPIYFTGLASEPGARSMNISIWGFTESFLTRQWVSYTIDFK 1869
            ++KFS DEG  W T+ F+   ++  GL SEPG  ++ ++++G         W    +DF+
Sbjct: 387  ILKFSVDEGLTWSTHNFTSTSVFVDGLLSEPGDETLVMTVFGHIS--FRSDWELVKVDFR 444

Query: 1870 DILERNCEEKDYTVWLAHSTDPGDYGDGCILGYKEQYLRLRKSSVCQNGRDYVVTKQPSV 2049
                R C E+DY+ W   +      GD C++G +  + R + +S C  GR +       V
Sbjct: 445  PSFSRQCSEQDYSSWDLTNLQ----GDRCVMGQQRSFRRRKPTSWCIKGRSFTAALAARV 500

Query: 2050 CPCSLEDFLCDFGYFRPEND----SKCVE----QPELKGHDLEFCLYGREEHLTTNGYRK 2205
            C C   DFLCD+G+ R  +     S C       P     D   C+ G + + ++ GYRK
Sbjct: 501  CQCRASDFLCDYGFERAPSSGSDASTCFANFWFNPLSPPDD---CVLG-QTYTSSLGYRK 556

Query: 2206 IPGDRCQGGVNPAREVKDLK 2265
            +    C+GGV+P +    L+
Sbjct: 557  VVSSACEGGVDPRQSPAQLQ 576


  Database: RefSeq49_SP.fasta
    Posted date:  Oct 17, 2011  1:42 PM
  Number of letters in database: 11,343,932
  Number of sequences in database:  24,897
  
Lambda     K      H
   0.318    0.134    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 24897
Number of Hits to DB: 69,880,004
Number of extensions: 2053059
Number of successful extensions: 6245
Number of sequences better than 1.0e-05: 9
Number of HSP's gapped: 6202
Number of HSP's successfully gapped: 18
Length of query: 909
Length of database: 11,343,932
Length adjustment: 108
Effective length of query: 801
Effective length of database: 8,655,056
Effective search space: 6932699856
Effective search space used: 6932699856
Neighboring words threshold: 12
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 35 (18.1 bits)

BLASTN 2.2.24 [Aug-08-2010]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= 20110601C-002457
         (2728 letters)

Database: Sscrofa_10.2.fasta 
           4582 sequences; 2,808,509,378 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

Sscrofa_Chr04                                                         387   e-104

>Sscrofa_Chr04 
||          Length = 143465943

 Score =  387 bits (195), Expect = e-104
 Identities = 195/195 (100%)
 Strand = Plus / Plus

                                                                             
Query: 1698      gttctccacagacgaaggtcagtgctggcaaacctacgtgtttagcagggagcctatcta 1757
                 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 121286835 gttctccacagacgaaggtcagtgctggcaaacctacgtgtttagcagggagcctatcta 121286894

                                                                             
Query: 1758      cttcactggcctggcctccgaacccggagctcggtccatgaacatcagcatctggggttt 1817
                 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 121286895 cttcactggcctggcctccgaacccggagctcggtccatgaacatcagcatctggggttt 121286954

                                                                             
Query: 1818      cacagagtctttcctgactcgccagtgggtctcctacaccatcgactttaaagatatcct 1877
                 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 121286955 cacagagtctttcctgactcgccagtgggtctcctacaccatcgactttaaagatatcct 121287014

                                
Query: 1878      tgaaaggaactgtga 1892
                 |||||||||||||||
Sbjct: 121287015 tgaaaggaactgtga 121287029



 Score =  377 bits (190), Expect = e-101
 Identities = 190/190 (100%)
 Strand = Plus / Plus

                                                                             
Query: 1889      gtgaagagaaggactacaccgtatggctggctcactccacggaccctggggattatggag 1948
                 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 121289372 gtgaagagaaggactacaccgtatggctggctcactccacggaccctggggattatggag 121289431

                                                                             
Query: 1949      atggctgcattttaggctataaggaacagtacctccggctgcgcaagtcgtccgtctgtc 2008
                 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 121289432 atggctgcattttaggctataaggaacagtacctccggctgcgcaagtcgtccgtctgtc 121289491

                                                                             
Query: 2009      agaatggtcgggactatgttgtgaccaagcagccgtccgtctgtccctgttccctggagg 2068
                 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 121289492 agaatggtcgggactatgttgtgaccaagcagccgtccgtctgtccctgttccctggagg 121289551

                           
Query: 2069      acttcctctg 2078
                 ||||||||||
Sbjct: 121289552 acttcctctg 121289561



 Score =  341 bits (172), Expect = 1e-90
 Identities = 172/172 (100%)
 Strand = Plus / Plus

                                                                             
Query: 1528      ggtagcgtgggagatgccatctcagtgatgatcccagatgtgtacatctcagatgacggg 1587
                 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 121285791 ggtagcgtgggagatgccatctcagtgatgatcccagatgtgtacatctcagatgacggg 121285850

                                                                             
Query: 1588      ggttactcctggctgaagatgctggaaggaccccactattacaccatcctggattccggg 1647
                 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 121285851 ggttactcctggctgaagatgctggaaggaccccactattacaccatcctggattccggg 121285910

                                                                     
Query: 1648      ggcatcattgtagccatcgagcacagcagccatcctatcaatgtgattaagt 1699
                 ||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 121285911 ggcatcattgtagccatcgagcacagcagccatcctatcaatgtgattaagt 121285962



 Score =  331 bits (167), Expect = 1e-87
 Identities = 167/167 (100%)
 Strand = Plus / Plus

                                                                             
Query: 596       aggtgattttaacagcagaggtgtcggggggaagtcatggaggaagaatcttcagatcat 655
                 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 121267751 aggtgattttaacagcagaggtgtcggggggaagtcatggaggaagaatcttcagatcat 121267810

                                                                             
Query: 656       cagattttgcaaagaacttcattcagaccaacctcccttttcaccctctgactcagatga 715
                 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 121267811 cagattttgcaaagaacttcattcagaccaacctcccttttcaccctctgactcagatga 121267870

                                                                
Query: 716       tgtatagccctcagaattctgatcatctgttagccctcagcaccgaa 762
                 |||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 121267871 tgtatagccctcagaattctgatcatctgttagccctcagcaccgaa 121267917



 Score =  313 bits (158), Expect = 3e-82
 Identities = 158/158 (100%)
 Strand = Plus / Plus

                                                                             
Query: 1161      agataccggatttggcaccatatttacctcggatgatcgaggcatcgtctattccaagtc 1220
                 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 121279686 agataccggatttggcaccatatttacctcggatgatcgaggcatcgtctattccaagtc 121279745

                                                                             
Query: 1221      cttggaccggcacctctacaccaccacaggtggcgagacagactttaccaacgtgacctc 1280
                 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 121279746 cttggaccggcacctctacaccaccacaggtggcgagacagactttaccaacgtgacctc 121279805

                                                       
Query: 1281      cctccgcggcgtctacatgacaagtgtgctatccgaag 1318
                 ||||||||||||||||||||||||||||||||||||||
Sbjct: 121279806 cctccgcggcgtctacatgacaagtgtgctatccgaag 121279843



 Score =  291 bits (147), Expect = 1e-75
 Identities = 147/147 (100%)
 Strand = Plus / Plus

                                                                             
Query: 1016      aggatacaaccagaaggattcatgtatcaacagatcaaggggacacatggagcatggccc 1075
                 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 121278452 aggatacaaccagaaggattcatgtatcaacagatcaaggggacacatggagcatggccc 121278511

                                                                             
Query: 1076      agctcccctctgtggggcaggagcagttctactctattctagcagctaacgatgacatgg 1135
                 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 121278512 agctcccctctgtggggcaggagcagttctactctattctagcagctaacgatgacatgg 121278571

                                            
Query: 1136      tgttcatgcacgtagacgagcctggag 1162
                 |||||||||||||||||||||||||||
Sbjct: 121278572 tgttcatgcacgtagacgagcctggag 121278598



 Score =  262 bits (132), Expect = 9e-67
 Identities = 132/132 (100%)
 Strand = Plus / Plus

                                                                             
Query: 887       aagctgaccttggggccctggaattacggagaacttcagacttggggaaaagcttcaaaa 946
                 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 121274690 aagctgaccttggggccctggaattacggagaacttcagacttggggaaaagcttcaaaa 121274749

                                                                             
Query: 947       ccattggtgtgaaaatctactcatttggtcttgggggacgtttcctttttgcctctgtga 1006
                 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 121274750 ccattggtgtgaaaatctactcatttggtcttgggggacgtttcctttttgcctctgtga 121274809

                             
Query: 1007      tggctgataagg 1018
                 ||||||||||||
Sbjct: 121274810 tggctgataagg 121274821



 Score =  230 bits (116), Expect = 3e-57
 Identities = 119/120 (99%)
 Strand = Plus / Minus

                                                                             
Query: 2078      gtgattttggctactttcgtccagaaaacgactccaagtgtgtcgaacagccagaactga 2137
                 |||||||||||||||| |||||||||||||||||||||||||||||||||||||||||||
Sbjct: 121330222 gtgattttggctacttccgtccagaaaacgactccaagtgtgtcgaacagccagaactga 121330163

                                                                             
Query: 2138      agggccatgacctagagttttgtctgtatgggagagaagagcacctgacgacaaatgggt 2197
                 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 121330162 agggccatgacctagagttttgtctgtatgggagagaagagcacctgacgacaaatgggt 121330103



 Score =  220 bits (111), Expect = 3e-54
 Identities = 111/111 (100%)
 Strand = Plus / Minus

                                                                             
Query: 2402      agaattccaagtcaagttctgttcccattatcctggccactgtgggactgatgctggtca 2461
                 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 121327720 agaattccaagtcaagttctgttcccattatcctggccactgtgggactgatgctggtca 121327661

                                                                    
Query: 2462      cagtcgtagccggagtgctcattgtgaagaaatacgtctgtgggggaaggt 2512
                 |||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 121327660 cagtcgtagccggagtgctcattgtgaagaaatacgtctgtgggggaaggt 121327610



 Score =  220 bits (111), Expect = 3e-54
 Identities = 111/111 (100%)
 Strand = Plus / Minus

                                                                             
Query: 2195      ggtaccggaaaattccaggagacagatgccagggtggagtgaatccagctcgagaagtaa 2254
                 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 121329242 ggtaccggaaaattccaggagacagatgccagggtggagtgaatccagctcgagaagtaa 121329183

                                                                    
Query: 2255      aagacttaaaaaagaaatgcacgagcaactttttgagtccagaaaaacagg 2305
                 |||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 121329182 aagacttaaaaaagaaatgcacgagcaactttttgagtccagaaaaacagg 121329132



 Score =  216 bits (109), Expect = 5e-53
 Identities = 109/109 (100%)
 Strand = Plus / Plus

                                                                             
Query: 1317      agataattctatccagactatgatcacttttgaccaaggaggaaggtggaaacacctgag 1376
                 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 121281750 agataattctatccagactatgatcacttttgaccaaggaggaaggtggaaacacctgag 121281809

                                                                  
Query: 1377      gaagcctgaaaacagtgaatgtgacgctaccgcaaaaaataagaacgag 1425
                 |||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 121281810 gaagcctgaaaacagtgaatgtgacgctaccgcaaaaaataagaacgag 121281858



 Score =  212 bits (107), Expect = 8e-52
 Identities = 107/107 (100%)
 Strand = Plus / Plus

                                                                             
Query: 1424      agtgcagccttcatattcacgcttcctacagcatctcccagaaactaaatgtcccaatgg 1483
                 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 121285398 agtgcagccttcatattcacgcttcctacagcatctcccagaaactaaatgtcccaatgg 121285457

                                                                
Query: 1484      ccccactctcagagcccaatgctgtcggcatagtcatcgcccacggt 1530
                 |||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 121285458 ccccactctcagagcccaatgctgtcggcatagtcatcgcccacggt 121285504



 Score =  208 bits (105), Expect = 1e-50
 Identities = 108/109 (99%)
 Strand = Plus / Plus

                                                                             
Query: 493       agtgaggactatggaaagaactttaaggatattacaaatctcatcaataacaccttcatt 552
                 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 121267153 agtgaggactatggaaagaactttaaggatattacaaatctcatcaataacaccttcatt 121267212

                                                                  
Query: 553       cgaactgaatttggcatggctattggtcctgagaactctgggaaggtga 601
                 ||||||||||||||||||||||| |||||||||||||||||||||||||
Sbjct: 121267213 cgaactgaatttggcatggctatcggtcctgagaactctgggaaggtga 121267261



 Score =  204 bits (103), Expect = 2e-49
 Identities = 103/103 (100%)
 Strand = Plus / Minus

                                                                             
Query: 2301      acaggactcccgcccacagggacacaacctgtcccagaatccagctccgcctcctcttgg 2360
                 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 121328380 acaggactcccgcccacagggacacaacctgtcccagaatccagctccgcctcctcttgg 121328321

                                                            
Query: 2361      atacactgaaaacacacactccctatctcccacccagaagcag 2403
                 |||||||||||||||||||||||||||||||||||||||||||
Sbjct: 121328320 atacactgaaaacacacactccctatctcccacccagaagcag 121328278



 Score =  200 bits (101), Expect = 3e-48
 Identities = 117/121 (96%), Gaps = 1/121 (0%)
 Strand = Plus / Minus

                                                                             
Query: 2514      ctggtgcaccgatactctgtgctccagcagcacgcggaggccaatggggtggatggcgtg 2573
                 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 121327342 ctggtgcaccgatactctgtgctccagcagcacgcggaggccaatggggtggatggcgtg 121327283

                                                                             
Query: 2574      gacgccctggacac-gccctccacaccactaaaagcggttatcacgatgactccgatgag 2632
                 |||||||||||||| |||  ||||||||||||||||||||||||||||||||| ||||||
Sbjct: 121327282 gacgccctggacacagcctcccacaccactaaaagcggttatcacgatgactcagatgag 121327223

                  
Query: 2633      g 2633
                 |
Sbjct: 121327222 g 121327222



 Score =  168 bits (85), Expect = 1e-38
 Identities = 85/85 (100%)
 Strand = Plus / Plus

                                                                             
Query: 276       ttggcgccgcagcgcgctcgatgaggacgaggactgcggcggggtccgggacttcgtcgc 335
                 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 121230136 ttggcgccgcagcgcgctcgatgaggacgaggactgcggcggggtccgggacttcgtcgc 121230195

                                          
Query: 336       caggctggccaacaacacacaccag 360
                 |||||||||||||||||||||||||
Sbjct: 121230196 caggctggccaacaacacacaccag 121230220



 Score =  149 bits (75), Expect = 9e-33
 Identities = 75/75 (100%)
 Strand = Plus / Plus

                                                                             
Query: 420       gatcatcctagtcctgactaccttccatgtaccactggtaattatgacttttggacagtc 479
                 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 121258428 gatcatcctagtcctgactaccttccatgtaccactggtaattatgacttttggacagtc 121258487

                                
Query: 480       caagctgtatcgaag 494
                 |||||||||||||||
Sbjct: 121258488 caagctgtatcgaag 121258502



 Score =  149 bits (75), Expect = 9e-33
 Identities = 75/75 (100%)
 Strand = Plus / Plus

                                                                             
Query: 763       aatggcctgtgggtgtccaagaattttgggggaaaatgggaagaaatccacaaagcagta 822
                 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 121270911 aatggcctgtgggtgtccaagaattttgggggaaaatgggaagaaatccacaaagcagta 121270970

                                
Query: 823       tgtttggccaaatgg 837
                 |||||||||||||||
Sbjct: 121270971 tgtttggccaaatgg 121270985



 Score =  125 bits (63), Expect = 1e-25
 Identities = 63/63 (100%)
 Strand = Plus / Plus

                                                                             
Query: 358       cagcatgtgtttgatgatctcagtggctcggtgtccttgtcctgggttggggatagcact 417
                 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 121256567 cagcatgtgtttgatgatctcagtggctcggtgtccttgtcctgggttggggatagcact 121256626

                    
Query: 418       ggg 420
                 |||
Sbjct: 121256627 ggg 121256629



 Score =  123 bits (62), Expect = 5e-25
 Identities = 89/98 (90%)
 Strand = Plus / Minus

                                                                             
Query: 2631      aggacctcctgagatacctcctcaaaggacctgggaccaagcatggatgagggaaccgcc 2690
                 |||||||||||  ||| |||||||||||| |||||||||||||||||||| |||||||| 
Sbjct: 121326907 aggacctcctggaatagctcctcaaaggagctgggaccaagcatggatgatggaaccgca 121326848

                                                       
Query: 2691      atacctcctaaactccctgtggctccaacttggggaaa 2728
                  ||||||||| ||||||||||||||| |||||||||||
Sbjct: 121326847 gtacctcctacactccctgtggctccgacttggggaaa 121326810



 Score = 93.7 bits (47), Expect = 5e-16
 Identities = 50/51 (98%)
 Strand = Plus / Plus

                                                                    
Query: 836       ggggatcagacagcaccatcttcttcaccacctatgtgaacggctcctgca 886
                 |||||||||||||||||||||||||||||||||||||||| ||||||||||
Sbjct: 121273759 ggggatcagacagcaccatcttcttcaccacctatgtgaatggctcctgca 121273809



 Score = 63.9 bits (32), Expect = 4e-07
 Identities = 32/32 (100%)
 Strand = Plus / Plus

                                                 
Query: 202       tggtccggccccgtcggggtgagctgggggct 233
                 ||||||||||||||||||||||||||||||||
Sbjct: 121230062 tggtccggccccgtcggggtgagctgggggct 121230093


  Database: Sscrofa_10.2.fasta
    Posted date:  Nov 16, 2011 10:34 AM
  Number of letters in database: 2,808,509,378
  Number of sequences in database:  4582
  
Lambda     K      H
    1.37    0.711     1.31 

Gapped
Lambda     K      H
    1.37    0.711     1.31 


Matrix: blastn matrix:1 -3
Gap Penalties: Existence: 5, Extension: 2
Number of Sequences: 4582
Number of Hits to DB: 72,181,403
Number of extensions: 364
Number of successful extensions: 364
Number of sequences better than 1.0e-05: 1
Number of HSP's gapped: 363
Number of HSP's successfully gapped: 22
Length of query: 2728
Length of database: 2,808,509,378
Length adjustment: 22
Effective length of query: 2706
Effective length of database: 2,808,408,574
Effective search space: 7599553601244
Effective search space used: 7599553601244
X1: 11 (21.8 bits)
X2: 15 (29.7 bits)
X3: 50 (99.1 bits)
S1: 18 (36.2 bits)
S2: 30 (60.0 bits)