Animal-Genome cDNA 20110601C-003003

BLASTX 2.2.24 [Aug-08-2010]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= 20110601C-003003
         (1053 letters)

Database: RefSeq49_BP.fasta 
           33,088 sequences; 17,681,374 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

Alignment   gi|NP_001077132.1| probable E3 ubiquitin-protein ligase HERC3 [...   518   e-151
Alignment   gi|NP_001070362.2| hect domain and RLD 4 [Bos taurus].               304   4e-85
Alignment   gi|NP_001179573.1| probable E3 ubiquitin-protein ligase HERC6 [...   253   2e-67
Alignment   gi|XP_002688230.1| PREDICTED: hect domain and RLD 6-like isofor...   253   2e-67
Alignment   gi|XP_002688229.1| PREDICTED: hect domain and RLD 6-like isofor...   253   2e-67
Alignment   gi|XP_002704581.1| PREDICTED: hect domain and RLD 6 isoform 1 [...   253   2e-67
Alignment   gi|NP_001193010.1| probable E3 ubiquitin-protein ligase HERC2 [...   163   3e-40
Alignment   gi|XP_002685237.1| PREDICTED: hect domain and RLD 3-like [Bos t...   163   3e-40
Alignment   gi|NP_001095465.1| probable E3 ubiquitin-protein ligase HERC5 [...   143   9e-36
Alignment   gi|NP_001179920.1| RCC1 and BTB domain-containing protein 2 [Bo...   143   2e-34

>ref|NP_001077132.1| probable E3 ubiquitin-protein ligase HERC3 [Bos taurus].
          Length = 1050

 Score =  518 bits (1334), Expect(2) = e-151
 Identities = 248/259 (95%), Positives = 255/259 (98%)
 Frame = +2

Query: 230  MLCWGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGDHSVFLLEDGEVYTCGL 409
            MLCWGYWSLGQPGIS NLQGIVAEPQVCGFISDRSVKEVACGG+HSVFLLEDGEVYTCG+
Sbjct: 1    MLCWGYWSLGQPGISPNLQGIVAEPQVCGFISDRSVKEVACGGNHSVFLLEDGEVYTCGV 60

Query: 410  NTKGQLGHEREGNKPEQIGALADEHIVHVACGESHSLALSDRGQLFSWGAGSDGQLGLMT 589
            NTKGQLGHEREGNKPEQIGALAD+HIVHVACGESHSLALSD+GQLFSWGAGSDGQLGLMT
Sbjct: 61   NTKGQLGHEREGNKPEQIGALADQHIVHVACGESHSLALSDQGQLFSWGAGSDGQLGLMT 120

Query: 590  TEESVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQAS 769
             E+SVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWG+NSHGQLGLGKEFPSQAS
Sbjct: 121  IEDSVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGRNSHGQLGLGKEFPSQAS 180

Query: 770  PQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEEDRESPCHVKLLR 949
            PQRVRSLEGIPLAQV AGGAHSFALSLSGAVFGWGMNNAGQLGLSDE+DRESPCHVKLLR
Sbjct: 181  PQRVRSLEGIPLAQVVAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEKDRESPCHVKLLR 240

Query: 950  AQKVVYISCGEEHTAVLTK 1006
             QKVVYISCGEEHTAVLTK
Sbjct: 241  TQKVVYISCGEEHTAVLTK 259



 Score = 37.7 bits (86), Expect(2) = e-151
 Identities = 16/17 (94%), Positives = 16/17 (94%)
 Frame = +1

Query: 1003 KSGGVFTFGAGSCGPLG 1053
            KSGGVFTFGAGSCG LG
Sbjct: 259  KSGGVFTFGAGSCGQLG 275



 Score =  129 bits (324), Expect = 4e-30
 Identities = 81/241 (33%), Positives = 127/241 (52%), Gaps = 4/241 (1%)
 Frame = +2

Query: 230 MLCWGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGDHSVFLLEDGEVYTCGL 409
           +  WG  S GQ G+ T ++  VA P++   ++ +++ +V+CG  H + L  DG+ +T G 
Sbjct: 105 LFSWGAGSDGQLGLMT-IEDSVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGR 163

Query: 410 NTKGQLGHERE---GNKPEQIGALADEHIVHVACGESHSLALSDRGQLFSWGAGSDGQLG 580
           N+ GQLG  +E      P+++ +L    +  V  G +HS ALS  G +F WG  + GQLG
Sbjct: 164 NSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVVAGGAHSFALSLSGAVFGWGMNNAGQLG 223

Query: 581 LMTTEESVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPS 760
           L + E+    P  ++ L  Q ++ +SCG  H   L   G  FT+G  S GQLG       
Sbjct: 224 L-SDEKDRESPCHVKLLRTQKVVYISCGEEHTAVLTKSGGVFTFGAGSCGQLG-HDSMND 281

Query: 761 QASPQRVRSLEGIPLAQVAAGGAHSFA-LSLSGAVFGWGMNNAGQLGLSDEEDRESPCHV 937
           + +P+RV  L G  + Q+A G  H+ A +  SG ++ +G    GQLG     + + P  V
Sbjct: 282 EVNPRRVLELMGSEVTQIACGRQHTLAFVPSSGLIYAFGCGARGQLGTGHTCNVKCPSPV 341

Query: 938 K 940
           K
Sbjct: 342 K 342


>ref|NP_001070362.2| hect domain and RLD 4 [Bos taurus].
          Length = 1057

 Score =  304 bits (778), Expect(2) = 4e-85
 Identities = 146/259 (56%), Positives = 190/259 (73%)
 Frame = +2

Query: 230  MLCWGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGDHSVFLLEDGEVYTCGL 409
            MLCWG  S GQ G+    + IV EP+   F  ++ V++V CG  H+VF+L+DG VYTCG 
Sbjct: 1    MLCWGNASFGQLGLGGIDEEIVLEPRKSDFFINKKVRDVGCGLRHTVFVLDDGTVYTCGC 60

Query: 410  NTKGQLGHEREGNKPEQIGALADEHIVHVACGESHSLALSDRGQLFSWGAGSDGQLGLMT 589
            N  GQLGHE+   KPEQ+ AL  ++IV V+CGE+H+LAL+D+GQ+++WG  SDGQLGL+ 
Sbjct: 61   NDLGQLGHEKSRKKPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGLLG 120

Query: 590  TEESVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQAS 769
            +EE + VPR I+ L+   I+QV+CG +H LAL+   + F WG+N +GQLGLG +   QAS
Sbjct: 121  SEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGIDCKKQAS 180

Query: 770  PQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEEDRESPCHVKLLR 949
            PQ ++SL GIP  Q+AAGGAHSF L+LSGA+FGWG N  GQLGL+DE DR  P  +K LR
Sbjct: 181  PQLIKSLLGIPFMQIAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLR 240

Query: 950  AQKVVYISCGEEHTAVLTK 1006
             QK+VYI CGE+HTA LTK
Sbjct: 241  TQKIVYICCGEDHTAALTK 259



 Score = 30.4 bits (67), Expect(2) = 4e-85
 Identities = 13/17 (76%), Positives = 13/17 (76%)
 Frame = +1

Query: 1003 KSGGVFTFGAGSCGPLG 1053
            K GGVFTFGAG  G LG
Sbjct: 259  KEGGVFTFGAGGYGQLG 275



 Score =  100 bits (250), Expect = 2e-21
 Identities = 58/179 (32%), Positives = 95/179 (53%), Gaps = 3/179 (1%)
 Frame = +2

Query: 218 RTQTMLCWGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGDHSVFLLEDGEVY 397
           +   + CWG    GQ G+  + +   A PQ+   +      ++A GG HS  L   G ++
Sbjct: 154 KASEVFCWGQNKYGQLGLGIDCKK-QASPQLIKSLLGIPFMQIAAGGAHSFVLTLSGAIF 212

Query: 398 TCGLNTKGQLGHEREGNK--PEQIGALADEHIVHVACGESHSLALSDRGQLFSWGAGSDG 571
             G N  GQLG   E ++  P  + +L  + IV++ CGE H+ AL+  G +F++GAG  G
Sbjct: 213 GWGRNKFGQLGLNDENDRYVPNLLKSLRTQKIVYICCGEDHTAALTKEGGVFTFGAGGYG 272

Query: 572 QLGLMTTEESVAVPRLIQKLNQQTILQVSCGNWHCLA-LAADGQFFTWGKNSHGQLGLG 745
           QLG  +T   +  PR + +L    + Q++CG  H  A + + G+ +++G   +GQLG G
Sbjct: 273 QLGHNSTSHEIN-PRKVFELMGSIVTQIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTG 330


>ref|NP_001179573.1| probable E3 ubiquitin-protein ligase HERC6 [Bos taurus].
          Length = 1016

 Score =  253 bits (647), Expect = 2e-67
 Identities = 132/241 (54%), Positives = 170/241 (70%), Gaps = 5/241 (2%)
 Frame = +2

Query: 299  EPQVCGFISDRSVKEVACGGDHSVFLLEDGEVYTCGLNTKGQLGHER--EGNKPEQIGAL 472
            E QVC      ++ + A G  HS+ LL DG V +CG N++GQLG +    G +PE+I AL
Sbjct: 15   ERQVCA--GGNTLLQAASGEHHSLLLLSDGTVQSCGDNSRGQLGRKGTPRGEQPERIPAL 72

Query: 473  ADEHIVHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTEESVAVPRLIQKLNQQTILQ 652
               ++  V+CG+ HSLA+  +G++F+WGA S+GQLG+   +E+  +P+ I+ L    I+Q
Sbjct: 73   ETLNVALVSCGKEHSLAVCHKGRVFAWGAASEGQLGIGEFKETTFIPKKIKTLAGIKIIQ 132

Query: 653  VSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAH 832
            V+CG++H +AL+ DGQ F+WG NSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGG H
Sbjct: 133  VACGHYHSVALSEDGQVFSWGTNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGHH 192

Query: 833  SFALSLSGAVFGWGMNNAGQLGLSDEE---DRESPCHVKLLRAQKVVYISCGEEHTAVLT 1003
            SFALSLSG  FGWG N+AGQL LS       R  P  +  L+   VV ISCG +HTAVLT
Sbjct: 193  SFALSLSGTSFGWGSNSAGQLALSGNNAPVQRYKPVSIGALKTLGVVSISCGYKHTAVLT 252

Query: 1004 K 1006
            +
Sbjct: 253  Q 253



 Score =  112 bits (281), Expect = 4e-25
 Identities = 78/221 (35%), Positives = 112/221 (50%), Gaps = 6/221 (2%)
 Frame = +2

Query: 230 MLCWGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGDHSVFLLEDGEVYTCGL 409
           +  WG  S GQ GI    +     P+    ++   + +VACG  HSV L EDG+V++ G 
Sbjct: 96  VFAWGAASEGQLGIG-EFKETTFIPKKIKTLAGIKIIQVACGHYHSVALSEDGQVFSWGT 154

Query: 410 NTKGQLGHERE---GNKPEQIGALADEHIVHVACGESHSLALSDRGQLFSWGAGSDGQLG 580
           N+ GQLG  +E      P+++ +L    +  VA G  HS ALS  G  F WG+ S GQL 
Sbjct: 155 NSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGHHSFALSLSGTSFGWGSNSAGQLA 214

Query: 581 LMTTEESVA--VPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEF 754
           L      V    P  I  L    ++ +SCG  H   L  DG+ FT+G NS+GQLG     
Sbjct: 215 LSGNNAPVQRYKPVSIGALKTLGVVSISCGYKHTAVLTQDGKVFTFGDNSYGQLG-HDPT 273

Query: 755 PSQASPQRVRSLEGIPLAQVAAGGAHSFA-LSLSGAVFGWG 874
             +  PQ V  +EG+ ++Q+  G  H+ A +  +G V  +G
Sbjct: 274 AEKRGPQLVERIEGL-VSQIDCGSDHTLAYIYTTGQVVSFG 313



 Score = 76.3 bits (186), Expect = 4e-14
 Identities = 56/168 (33%), Positives = 84/168 (50%), Gaps = 8/168 (4%)
 Frame = +2

Query: 239 WGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGDHSVFLLEDGEVYTCGLNTK 418
           WG  S GQ G+        A PQ    +    + +VA GG HS  L   G  +  G N+ 
Sbjct: 152 WGTNSHGQLGLGKEFPS-QASPQRVRSLEGIPLAQVAAGGHHSFALSLSGTSFGWGSNSA 210

Query: 419 GQLGHEREGN-------KPEQIGALADEHIVHVACGESHSLALSDRGQLFSWGAGSDGQL 577
           GQL     GN       KP  IGAL    +V ++CG  H+  L+  G++F++G  S GQL
Sbjct: 211 GQLA--LSGNNAPVQRYKPVSIGALKTLGVVSISCGYKHTAVLTQDGKVFTFGDNSYGQL 268

Query: 578 GLMTTEESVAVPRLIQKLNQQTILQVSCGNWHCLA-LAADGQFFTWGK 718
           G   T E    P+L++++ +  + Q+ CG+ H LA +   GQ  ++G+
Sbjct: 269 GHDPTAEKRG-PQLVERI-EGLVSQIDCGSDHTLAYIYTTGQVVSFGR 314



 Score = 59.7 bits (143), Expect = 4e-09
 Identities = 38/115 (33%), Positives = 58/115 (50%), Gaps = 3/115 (2%)
 Frame = +2

Query: 227 TMLCWGYWSLGQPGISTNLQGIVA-EPQVCGFISDRSVKEVACGGDHSVFLLEDGEVYTC 403
           T   WG  S GQ  +S N   +   +P   G +    V  ++CG  H+  L +DG+V+T 
Sbjct: 201 TSFGWGSNSAGQLALSGNNAPVQRYKPVSIGALKTLGVVSISCGYKHTAVLTQDGKVFTF 260

Query: 404 GLNTKGQLGHEREGNK-PEQIGALADEHIVHVACGESHSLA-LSDRGQLFSWGAG 562
           G N+ GQLGH+    K   Q+    +  +  + CG  H+LA +   GQ+ S+G G
Sbjct: 261 GDNSYGQLGHDPTAEKRGPQLVERIEGLVSQIDCGSDHTLAYIYTTGQVVSFGRG 315


>ref|XP_002688230.1| PREDICTED: hect domain and RLD 6-like isoform 2 [Bos taurus].
          Length = 1016

 Score =  253 bits (647), Expect = 2e-67
 Identities = 132/241 (54%), Positives = 170/241 (70%), Gaps = 5/241 (2%)
 Frame = +2

Query: 299  EPQVCGFISDRSVKEVACGGDHSVFLLEDGEVYTCGLNTKGQLGHER--EGNKPEQIGAL 472
            E QVC      ++ + A G  HS+ LL DG V +CG N++GQLG +    G +PE+I AL
Sbjct: 15   ERQVCA--GGNTLLQAASGEHHSLLLLSDGTVQSCGDNSRGQLGRKGTPRGEQPERIPAL 72

Query: 473  ADEHIVHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTEESVAVPRLIQKLNQQTILQ 652
               ++  V+CG+ HSLA+  +G++F+WGA S+GQLG+   +E+  +P+ I+ L    I+Q
Sbjct: 73   ETLNVALVSCGKEHSLAVCHKGRVFAWGAASEGQLGIGEFKETTFIPKKIKTLAGIKIIQ 132

Query: 653  VSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAH 832
            V+CG++H +AL+ DGQ F+WG NSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGG H
Sbjct: 133  VACGHYHSVALSEDGQVFSWGTNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGHH 192

Query: 833  SFALSLSGAVFGWGMNNAGQLGLSDEE---DRESPCHVKLLRAQKVVYISCGEEHTAVLT 1003
            SFALSLSG  FGWG N+AGQL LS       R  P  +  L+   VV ISCG +HTAVLT
Sbjct: 193  SFALSLSGTSFGWGSNSAGQLALSGNNAPVQRYKPVSIGALKTLGVVSISCGYKHTAVLT 252

Query: 1004 K 1006
            +
Sbjct: 253  Q 253



 Score =  112 bits (281), Expect = 4e-25
 Identities = 78/221 (35%), Positives = 112/221 (50%), Gaps = 6/221 (2%)
 Frame = +2

Query: 230 MLCWGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGDHSVFLLEDGEVYTCGL 409
           +  WG  S GQ GI    +     P+    ++   + +VACG  HSV L EDG+V++ G 
Sbjct: 96  VFAWGAASEGQLGIG-EFKETTFIPKKIKTLAGIKIIQVACGHYHSVALSEDGQVFSWGT 154

Query: 410 NTKGQLGHERE---GNKPEQIGALADEHIVHVACGESHSLALSDRGQLFSWGAGSDGQLG 580
           N+ GQLG  +E      P+++ +L    +  VA G  HS ALS  G  F WG+ S GQL 
Sbjct: 155 NSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGHHSFALSLSGTSFGWGSNSAGQLA 214

Query: 581 LMTTEESVA--VPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEF 754
           L      V    P  I  L    ++ +SCG  H   L  DG+ FT+G NS+GQLG     
Sbjct: 215 LSGNNAPVQRYKPVSIGALKTLGVVSISCGYKHTAVLTQDGKVFTFGDNSYGQLG-HDPT 273

Query: 755 PSQASPQRVRSLEGIPLAQVAAGGAHSFA-LSLSGAVFGWG 874
             +  PQ V  +EG+ ++Q+  G  H+ A +  +G V  +G
Sbjct: 274 AEKRGPQLVERIEGL-VSQIDCGSDHTLAYIYTTGQVVSFG 313



 Score = 76.3 bits (186), Expect = 4e-14
 Identities = 56/168 (33%), Positives = 84/168 (50%), Gaps = 8/168 (4%)
 Frame = +2

Query: 239 WGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGDHSVFLLEDGEVYTCGLNTK 418
           WG  S GQ G+        A PQ    +    + +VA GG HS  L   G  +  G N+ 
Sbjct: 152 WGTNSHGQLGLGKEFPS-QASPQRVRSLEGIPLAQVAAGGHHSFALSLSGTSFGWGSNSA 210

Query: 419 GQLGHEREGN-------KPEQIGALADEHIVHVACGESHSLALSDRGQLFSWGAGSDGQL 577
           GQL     GN       KP  IGAL    +V ++CG  H+  L+  G++F++G  S GQL
Sbjct: 211 GQLA--LSGNNAPVQRYKPVSIGALKTLGVVSISCGYKHTAVLTQDGKVFTFGDNSYGQL 268

Query: 578 GLMTTEESVAVPRLIQKLNQQTILQVSCGNWHCLA-LAADGQFFTWGK 718
           G   T E    P+L++++ +  + Q+ CG+ H LA +   GQ  ++G+
Sbjct: 269 GHDPTAEKRG-PQLVERI-EGLVSQIDCGSDHTLAYIYTTGQVVSFGR 314



 Score = 59.7 bits (143), Expect = 4e-09
 Identities = 38/115 (33%), Positives = 58/115 (50%), Gaps = 3/115 (2%)
 Frame = +2

Query: 227 TMLCWGYWSLGQPGISTNLQGIVA-EPQVCGFISDRSVKEVACGGDHSVFLLEDGEVYTC 403
           T   WG  S GQ  +S N   +   +P   G +    V  ++CG  H+  L +DG+V+T 
Sbjct: 201 TSFGWGSNSAGQLALSGNNAPVQRYKPVSIGALKTLGVVSISCGYKHTAVLTQDGKVFTF 260

Query: 404 GLNTKGQLGHEREGNK-PEQIGALADEHIVHVACGESHSLA-LSDRGQLFSWGAG 562
           G N+ GQLGH+    K   Q+    +  +  + CG  H+LA +   GQ+ S+G G
Sbjct: 261 GDNSYGQLGHDPTAEKRGPQLVERIEGLVSQIDCGSDHTLAYIYTTGQVVSFGRG 315


>ref|XP_002688229.1| PREDICTED: hect domain and RLD 6-like isoform 1 [Bos taurus].
          Length = 980

 Score =  253 bits (647), Expect = 2e-67
 Identities = 132/241 (54%), Positives = 170/241 (70%), Gaps = 5/241 (2%)
 Frame = +2

Query: 299  EPQVCGFISDRSVKEVACGGDHSVFLLEDGEVYTCGLNTKGQLGHER--EGNKPEQIGAL 472
            E QVC      ++ + A G  HS+ LL DG V +CG N++GQLG +    G +PE+I AL
Sbjct: 15   ERQVCA--GGNTLLQAASGEHHSLLLLSDGTVQSCGDNSRGQLGRKGTPRGEQPERIPAL 72

Query: 473  ADEHIVHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTEESVAVPRLIQKLNQQTILQ 652
               ++  V+CG+ HSLA+  +G++F+WGA S+GQLG+   +E+  +P+ I+ L    I+Q
Sbjct: 73   ETLNVALVSCGKEHSLAVCHKGRVFAWGAASEGQLGIGEFKETTFIPKKIKTLAGIKIIQ 132

Query: 653  VSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAH 832
            V+CG++H +AL+ DGQ F+WG NSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGG H
Sbjct: 133  VACGHYHSVALSEDGQVFSWGTNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGHH 192

Query: 833  SFALSLSGAVFGWGMNNAGQLGLSDEE---DRESPCHVKLLRAQKVVYISCGEEHTAVLT 1003
            SFALSLSG  FGWG N+AGQL LS       R  P  +  L+   VV ISCG +HTAVLT
Sbjct: 193  SFALSLSGTSFGWGSNSAGQLALSGNNAPVQRYKPVSIGALKTLGVVSISCGYKHTAVLT 252

Query: 1004 K 1006
            +
Sbjct: 253  Q 253



 Score =  112 bits (281), Expect = 4e-25
 Identities = 78/221 (35%), Positives = 112/221 (50%), Gaps = 6/221 (2%)
 Frame = +2

Query: 230 MLCWGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGDHSVFLLEDGEVYTCGL 409
           +  WG  S GQ GI    +     P+    ++   + +VACG  HSV L EDG+V++ G 
Sbjct: 96  VFAWGAASEGQLGIG-EFKETTFIPKKIKTLAGIKIIQVACGHYHSVALSEDGQVFSWGT 154

Query: 410 NTKGQLGHERE---GNKPEQIGALADEHIVHVACGESHSLALSDRGQLFSWGAGSDGQLG 580
           N+ GQLG  +E      P+++ +L    +  VA G  HS ALS  G  F WG+ S GQL 
Sbjct: 155 NSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGHHSFALSLSGTSFGWGSNSAGQLA 214

Query: 581 LMTTEESVA--VPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEF 754
           L      V    P  I  L    ++ +SCG  H   L  DG+ FT+G NS+GQLG     
Sbjct: 215 LSGNNAPVQRYKPVSIGALKTLGVVSISCGYKHTAVLTQDGKVFTFGDNSYGQLG-HDPT 273

Query: 755 PSQASPQRVRSLEGIPLAQVAAGGAHSFA-LSLSGAVFGWG 874
             +  PQ V  +EG+ ++Q+  G  H+ A +  +G V  +G
Sbjct: 274 AEKRGPQLVERIEGL-VSQIDCGSDHTLAYIYTTGQVVSFG 313



 Score = 76.3 bits (186), Expect = 4e-14
 Identities = 56/168 (33%), Positives = 84/168 (50%), Gaps = 8/168 (4%)
 Frame = +2

Query: 239 WGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGDHSVFLLEDGEVYTCGLNTK 418
           WG  S GQ G+        A PQ    +    + +VA GG HS  L   G  +  G N+ 
Sbjct: 152 WGTNSHGQLGLGKEFPS-QASPQRVRSLEGIPLAQVAAGGHHSFALSLSGTSFGWGSNSA 210

Query: 419 GQLGHEREGN-------KPEQIGALADEHIVHVACGESHSLALSDRGQLFSWGAGSDGQL 577
           GQL     GN       KP  IGAL    +V ++CG  H+  L+  G++F++G  S GQL
Sbjct: 211 GQLA--LSGNNAPVQRYKPVSIGALKTLGVVSISCGYKHTAVLTQDGKVFTFGDNSYGQL 268

Query: 578 GLMTTEESVAVPRLIQKLNQQTILQVSCGNWHCLA-LAADGQFFTWGK 718
           G   T E    P+L++++ +  + Q+ CG+ H LA +   GQ  ++G+
Sbjct: 269 GHDPTAEKRG-PQLVERI-EGLVSQIDCGSDHTLAYIYTTGQVVSFGR 314



 Score = 59.7 bits (143), Expect = 4e-09
 Identities = 38/115 (33%), Positives = 58/115 (50%), Gaps = 3/115 (2%)
 Frame = +2

Query: 227 TMLCWGYWSLGQPGISTNLQGIVA-EPQVCGFISDRSVKEVACGGDHSVFLLEDGEVYTC 403
           T   WG  S GQ  +S N   +   +P   G +    V  ++CG  H+  L +DG+V+T 
Sbjct: 201 TSFGWGSNSAGQLALSGNNAPVQRYKPVSIGALKTLGVVSISCGYKHTAVLTQDGKVFTF 260

Query: 404 GLNTKGQLGHEREGNK-PEQIGALADEHIVHVACGESHSLA-LSDRGQLFSWGAG 562
           G N+ GQLGH+    K   Q+    +  +  + CG  H+LA +   GQ+ S+G G
Sbjct: 261 GDNSYGQLGHDPTAEKRGPQLVERIEGLVSQIDCGSDHTLAYIYTTGQVVSFGRG 315


>ref|XP_002704581.1| PREDICTED: hect domain and RLD 6 isoform 1 [Bos taurus].
          Length = 980

 Score =  253 bits (647), Expect = 2e-67
 Identities = 132/241 (54%), Positives = 170/241 (70%), Gaps = 5/241 (2%)
 Frame = +2

Query: 299  EPQVCGFISDRSVKEVACGGDHSVFLLEDGEVYTCGLNTKGQLGHER--EGNKPEQIGAL 472
            E QVC      ++ + A G  HS+ LL DG V +CG N++GQLG +    G +PE+I AL
Sbjct: 15   ERQVCA--GGNTLLQAASGEHHSLLLLSDGTVQSCGDNSRGQLGRKGTPRGEQPERIPAL 72

Query: 473  ADEHIVHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTEESVAVPRLIQKLNQQTILQ 652
               ++  V+CG+ HSLA+  +G++F+WGA S+GQLG+   +E+  +P+ I+ L    I+Q
Sbjct: 73   ETLNVALVSCGKEHSLAVCHKGRVFAWGAASEGQLGIGEFKETTFIPKKIKTLAGIKIIQ 132

Query: 653  VSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAH 832
            V+CG++H +AL+ DGQ F+WG NSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGG H
Sbjct: 133  VACGHYHSVALSEDGQVFSWGTNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGHH 192

Query: 833  SFALSLSGAVFGWGMNNAGQLGLSDEE---DRESPCHVKLLRAQKVVYISCGEEHTAVLT 1003
            SFALSLSG  FGWG N+AGQL LS       R  P  +  L+   VV ISCG +HTAVLT
Sbjct: 193  SFALSLSGTSFGWGSNSAGQLALSGNNAPVQRYKPVSIGALKTLGVVSISCGYKHTAVLT 252

Query: 1004 K 1006
            +
Sbjct: 253  Q 253



 Score =  112 bits (281), Expect = 4e-25
 Identities = 78/221 (35%), Positives = 112/221 (50%), Gaps = 6/221 (2%)
 Frame = +2

Query: 230 MLCWGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGDHSVFLLEDGEVYTCGL 409
           +  WG  S GQ GI    +     P+    ++   + +VACG  HSV L EDG+V++ G 
Sbjct: 96  VFAWGAASEGQLGIG-EFKETTFIPKKIKTLAGIKIIQVACGHYHSVALSEDGQVFSWGT 154

Query: 410 NTKGQLGHERE---GNKPEQIGALADEHIVHVACGESHSLALSDRGQLFSWGAGSDGQLG 580
           N+ GQLG  +E      P+++ +L    +  VA G  HS ALS  G  F WG+ S GQL 
Sbjct: 155 NSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGHHSFALSLSGTSFGWGSNSAGQLA 214

Query: 581 LMTTEESVA--VPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEF 754
           L      V    P  I  L    ++ +SCG  H   L  DG+ FT+G NS+GQLG     
Sbjct: 215 LSGNNAPVQRYKPVSIGALKTLGVVSISCGYKHTAVLTQDGKVFTFGDNSYGQLG-HDPT 273

Query: 755 PSQASPQRVRSLEGIPLAQVAAGGAHSFA-LSLSGAVFGWG 874
             +  PQ V  +EG+ ++Q+  G  H+ A +  +G V  +G
Sbjct: 274 AEKRGPQLVERIEGL-VSQIDCGSDHTLAYIYTTGQVVSFG 313



 Score = 76.3 bits (186), Expect = 4e-14
 Identities = 56/168 (33%), Positives = 84/168 (50%), Gaps = 8/168 (4%)
 Frame = +2

Query: 239 WGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGDHSVFLLEDGEVYTCGLNTK 418
           WG  S GQ G+        A PQ    +    + +VA GG HS  L   G  +  G N+ 
Sbjct: 152 WGTNSHGQLGLGKEFPS-QASPQRVRSLEGIPLAQVAAGGHHSFALSLSGTSFGWGSNSA 210

Query: 419 GQLGHEREGN-------KPEQIGALADEHIVHVACGESHSLALSDRGQLFSWGAGSDGQL 577
           GQL     GN       KP  IGAL    +V ++CG  H+  L+  G++F++G  S GQL
Sbjct: 211 GQLA--LSGNNAPVQRYKPVSIGALKTLGVVSISCGYKHTAVLTQDGKVFTFGDNSYGQL 268

Query: 578 GLMTTEESVAVPRLIQKLNQQTILQVSCGNWHCLA-LAADGQFFTWGK 718
           G   T E    P+L++++ +  + Q+ CG+ H LA +   GQ  ++G+
Sbjct: 269 GHDPTAEKRG-PQLVERI-EGLVSQIDCGSDHTLAYIYTTGQVVSFGR 314



 Score = 59.7 bits (143), Expect = 4e-09
 Identities = 38/115 (33%), Positives = 58/115 (50%), Gaps = 3/115 (2%)
 Frame = +2

Query: 227 TMLCWGYWSLGQPGISTNLQGIVA-EPQVCGFISDRSVKEVACGGDHSVFLLEDGEVYTC 403
           T   WG  S GQ  +S N   +   +P   G +    V  ++CG  H+  L +DG+V+T 
Sbjct: 201 TSFGWGSNSAGQLALSGNNAPVQRYKPVSIGALKTLGVVSISCGYKHTAVLTQDGKVFTF 260

Query: 404 GLNTKGQLGHEREGNK-PEQIGALADEHIVHVACGESHSLA-LSDRGQLFSWGAG 562
           G N+ GQLGH+    K   Q+    +  +  + CG  H+LA +   GQ+ S+G G
Sbjct: 261 GDNSYGQLGHDPTAEKRGPQLVERIEGLVSQIDCGSDHTLAYIYTTGQVVSFGRG 315


>ref|NP_001193010.1| probable E3 ubiquitin-protein ligase HERC2 [Bos taurus].
          Length = 4837

 Score =  163 bits (412), Expect = 3e-40
 Identities = 93/271 (34%), Positives = 140/271 (51%), Gaps = 4/271 (1%)
 Frame = +2

Query: 239  WGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGDHSVFLLEDGEVYTCGLNTK 418
            WG    G+ G  + +     +P++   +  + ++++ACG  HS  L   GE+YT GL   
Sbjct: 3072 WGEGDDGKLGHFSRMN--CDKPRLIEALKTKRIRDIACGSSHSAALTSSGELYTWGLGEY 3129

Query: 419  GQLGHEREGN--KPEQIGALADEHIVHVACG--ESHSLALSDRGQLFSWGAGSDGQLGLM 586
            G+LGH       KP+ +  L    ++ VACG  ++ +LAL+D G +FSWG G  G+LG  
Sbjct: 3130 GRLGHGDNTTQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFSWGDGDFGKLG-R 3188

Query: 587  TTEESVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQA 766
               E   +P+ I++LN Q + Q+ CG    LAL   G  +TWGK  + +LG G +   + 
Sbjct: 3189 GGSEGCNIPQNIERLNGQGVCQIECGAQFSLALTKSGVVWTWGKGDYFRLGHGSDVHVR- 3247

Query: 767  SPQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEEDRESPCHVKLL 946
             PQ V  L G  +  VA G  H  A++ +G V+ WG N+ GQ G         P  V+ L
Sbjct: 3248 KPQVVEGLRGKKIVHVAVGALHCLAVTDAGQVYAWGDNDHGQQGNGTTTVNRKPTLVQGL 3307

Query: 947  RAQKVVYISCGEEHTAVLTKVEVCLPLVLVP 1039
              QK+  ++CG  H+   T V+V  P V  P
Sbjct: 3308 EGQKITRVACGSSHSVAWTTVDVATPSVHEP 3338



 Score =  134 bits (336), Expect = 2e-31
 Identities = 93/262 (35%), Positives = 136/262 (51%), Gaps = 9/262 (3%)
 Frame = +2

Query: 248  WSLGQPGISTNLQGI-VAEPQVCGFISDRSVKEVACGGDHSVFLLE-DGEVYTCGLNTKG 421
            W L        L+G  +  P     +S  +V +VA GG  S+F +  +G+VY CG  T G
Sbjct: 2965 WGLNDKDQLGGLKGSKIKVPSFSETLSALNVVQVA-GGSKSLFAVTVEGKVYACGEATNG 3023

Query: 422  QLGHEREGNK---PEQIGALADEHIVHVA--CGESHSLALSDRGQLFSWGAGSDGQLGLM 586
            +LG          P QI AL+   +  VA   G  H+ AL+  G++FSWG G DG+LG  
Sbjct: 3024 RLGLGISSGTVPIPRQITALSSYVVKKVAVHSGGRHATALTVDGKVFSWGEGDDGKLGHF 3083

Query: 587  TTEESVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQA 766
             +  +   PRLI+ L  + I  ++CG+ H  AL + G+ +TWG   +G+LG G +  +Q 
Sbjct: 3084 -SRMNCDKPRLIEALKTKRIRDIACGSSHSAALTSSGELYTWGLGEYGRLGHG-DNTTQL 3141

Query: 767  SPQRVRSLEGIPLAQVAAGG--AHSFALSLSGAVFGWGMNNAGQLGLSDEEDRESPCHVK 940
             P+ V+ L G  + QVA G   A + AL+  G VF WG  + G+LG    E    P +++
Sbjct: 3142 KPKMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFSWGDGDFGKLGRGGSEGCNIPQNIE 3201

Query: 941  LLRAQKVVYISCGEEHTAVLTK 1006
             L  Q V  I CG + +  LTK
Sbjct: 3202 RLNGQGVCQIECGAQFSLALTK 3223



 Score =  132 bits (332), Expect = 5e-31
 Identities = 79/234 (33%), Positives = 120/234 (51%), Gaps = 4/234 (1%)
 Frame = +2

Query: 302  PQVCGFISDRSVKEVACGGDHSVFLLEDGEVYTCGLNTKGQLGHEREGN--KPEQIGALA 475
            P+V   +    V +VA GG HS  +   G++YT G    G+LGH    +  KP+ + AL 
Sbjct: 4085 PRVIESLRGTEVVDVAAGGAHSACVTAAGDLYTWGKGRYGRLGHSDSEDQLKPKLVEALQ 4144

Query: 476  DEHIVHVACG--ESHSLALSDRGQLFSWGAGSDGQLGLMTTEESVAVPRLIQKLNQQTIL 649
               +V VACG  ++ +L L+D   ++SWG G  G+LG     +   VP  I  L    ++
Sbjct: 4145 GHRVVDVACGSGDAQTLCLTDDDTVWSWGDGDYGKLG-RGGSDGCKVPMKIDSLTGLGVV 4203

Query: 650  QVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGA 829
            +V CG+   +AL   G  +TWGK  + +LG G +      P++V+ L+G  +  +A G  
Sbjct: 4204 KVECGSQFSVALTKSGAVYTWGKGDYHRLGHGSD-DHVRRPRQVQGLQGKKVIAIATGSL 4262

Query: 830  HSFALSLSGAVFGWGMNNAGQLGLSDEEDRESPCHVKLLRAQKVVYISCGEEHT 991
            H    S  G V+ WG N+ GQLG       + P  V  L+ +KV  ++CG  HT
Sbjct: 4263 HCVCCSEDGEVYTWGDNDEGQLGDGTTNAIQRPRLVAALQGKKVNRVACGSAHT 4316



 Score =  131 bits (330), Expect = 9e-31
 Identities = 77/245 (31%), Positives = 135/245 (55%), Gaps = 10/245 (4%)
 Frame = +2

Query: 302  PQVCGFISDRSVKEVACGGD--HSVFLLEDGEVYTCGLNTKGQLGHEREG--NKPEQIGA 469
            PQ+   ++ R++ ++A   D  H + L   GEVY+ G    G+LGH       +P+ I A
Sbjct: 485  PQLVQGLASRNIVKIAAHSDGHHYLALAATGEVYSWGCGDGGRLGHGDTVPLEEPKVISA 544

Query: 470  L----ADEHIVHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTEESVAVPRLIQKLNQ 637
                 A +H+VH+ACG ++S A++  G+L++WG G+ G+LG  ++E+  A+P L+  L  
Sbjct: 545  FSGKQAGKHVVHIACGSTYSAAITAEGELYTWGRGNYGRLGHGSSEDE-AIPMLVAGLKG 603

Query: 638  QTILQVSCGNW--HCLALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQ 811
              ++ V+CG+     LA+  +GQ ++WG   +G+LG G       +P+ +  L+ + + +
Sbjct: 604  LKVIDVACGSGDAQTLAVTENGQVWSWGDGDYGKLGRGGS-DGCKTPKLIEKLQDLDVVK 662

Query: 812  VAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEEDRESPCHVKLLRAQKVVYISCGEEHT 991
            V  G   S AL+  G V+ WG  +  +LG   EE    P  ++ L+ +KV+ ++ G  H 
Sbjct: 663  VRCGSQFSVALTKDGQVYSWGKGDNQRLGHGTEEHVRYPKLLEGLQGKKVIDVAAGSTHC 722

Query: 992  AVLTK 1006
              LT+
Sbjct: 723  LALTE 727



 Score =  125 bits (315), Expect = 5e-29
 Identities = 81/261 (31%), Positives = 131/261 (50%), Gaps = 8/261 (3%)
 Frame = +2

Query: 221  TQTMLCWGYWSLGQPGISTNLQGIVAEPQVCGFISDRS----VKEVACGGDHSVFLLEDG 388
            T  +  WG    G+ G    +   + EP+V    S +     V  +ACG  +S  +  +G
Sbjct: 514  TGEVYSWGCGDGGRLGHGDTVP--LEEPKVISAFSGKQAGKHVVHIACGSTYSAAITAEG 571

Query: 389  EVYTCGLNTKGQLGHEREGNK--PEQIGALADEHIVHVACG--ESHSLALSDRGQLFSWG 556
            E+YT G    G+LGH    ++  P  +  L    ++ VACG  ++ +LA+++ GQ++SWG
Sbjct: 572  ELYTWGRGNYGRLGHGSSEDEAIPMLVAGLKGLKVIDVACGSGDAQTLAVTENGQVWSWG 631

Query: 557  AGSDGQLGLMTTEESVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQL 736
             G  G+LG     +    P+LI+KL    +++V CG+   +AL  DGQ ++WGK  + +L
Sbjct: 632  DGDYGKLG-RGGSDGCKTPKLIEKLQDLDVVKVRCGSQFSVALTKDGQVYSWGKGDNQRL 690

Query: 737  GLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEED 916
            G G E      P+ +  L+G  +  VAAG  H  AL+    V  WG N+  Q   +    
Sbjct: 691  GHGTE-EHVRYPKLLEGLQGKKVIDVAAGSTHCLALTEDSEVHSWGSNDQCQHFDTLRVT 749

Query: 917  RESPCHVKLLRAQKVVYISCG 979
            +  P  +  L  + +V I+CG
Sbjct: 750  KPEPSALPGLDTKHIVGIACG 770



 Score =  125 bits (313), Expect = 8e-29
 Identities = 77/203 (37%), Positives = 117/203 (57%), Gaps = 5/203 (2%)
 Frame = +2

Query: 386  GEVYTCGLNTKGQLGHEREGNK---PEQIGALADEHIVHVACGESHSLALSDRGQLFSWG 556
            G +Y  G N +GQLG   EG K   P    ALA    V +  GE    A++  G+L++ G
Sbjct: 3955 GTIYGWGHNHRGQLGGI-EGAKVKVPTPCEALAALRPVQLIGGEQTLFAVTADGKLYATG 4013

Query: 557  AGSDGQLGLMTTEESVAVPRLIQKLNQQTI--LQVSCGNWHCLALAADGQFFTWGKNSHG 730
             G+ G+LG+  TE SV+ P L++ +    I  + V+ G  HCLAL+++G+ ++WG+   G
Sbjct: 4014 YGAGGRLGVGGTE-SVSTPTLLESIQHVFIKKVAVNSGGKHCLALSSEGEVYSWGEAEDG 4072

Query: 731  QLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDE 910
            +LG G   P    P+ + SL G  +  VAAGGAHS  ++ +G ++ WG    G+LG SD 
Sbjct: 4073 KLGHGNRSPCDR-PRVIESLRGTEVVDVAAGGAHSACVTAAGDLYTWGKGRYGRLGHSDS 4131

Query: 911  EDRESPCHVKLLRAQKVVYISCG 979
            ED+  P  V+ L+  +VV ++CG
Sbjct: 4132 EDQLKPKLVEALQGHRVVDVACG 4154



 Score =  118 bits (296), Expect = 8e-27
 Identities = 71/245 (28%), Positives = 127/245 (51%), Gaps = 7/245 (2%)
 Frame = +2

Query: 293  VAEPQVCGFISDRSVKEVACGGDHSVFLLEDGEVYTCGLNTKGQLGHEREGNKPEQIGAL 472
            V  P  C  +++  V ++AC     + L  +G VYT   N+        +   P+ +  L
Sbjct: 440  VIGPIQCEGLANLGVTQIACAEKRFLILSRNGRVYTQAYNS--------DTLAPQLVQGL 491

Query: 473  ADEHIVHVACGES--HSLALSDRGQLFSWGAGSDGQLG---LMTTEESVAVPRLIQKLNQ 637
            A  +IV +A      H LAL+  G+++SWG G  G+LG    +  EE   +     K   
Sbjct: 492  ASRNIVKIAAHSDGHHYLALAATGEVYSWGCGDGGRLGHGDTVPLEEPKVISAFSGKQAG 551

Query: 638  QTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVA 817
            + ++ ++CG+ +  A+ A+G+ +TWG+ ++G+LG G     +A P  V  L+G+ +  VA
Sbjct: 552  KHVVHIACGSTYSAAITAEGELYTWGRGNYGRLGHGSS-EDEAIPMLVAGLKGLKVIDVA 610

Query: 818  --AGGAHSFALSLSGAVFGWGMNNAGQLGLSDEEDRESPCHVKLLRAQKVVYISCGEEHT 991
              +G A + A++ +G V+ WG  + G+LG    +  ++P  ++ L+   VV + CG + +
Sbjct: 611  CGSGDAQTLAVTENGQVWSWGDGDYGKLGRGGSDGCKTPKLIEKLQDLDVVKVRCGSQFS 670

Query: 992  AVLTK 1006
              LTK
Sbjct: 671  VALTK 675



 Score =  109 bits (273), Expect(2) = 3e-24
 Identities = 81/269 (30%), Positives = 129/269 (47%), Gaps = 9/269 (3%)
 Frame = +2

Query: 227  TMLCWGYWSLGQPGISTNLQGI-VAEPQVCGFISD-RSVKEVACGGDHSVFLLE-DGEVY 397
            T+  WG+   GQ G    ++G  V  P  C  ++  R V+ +  GG+ ++F +  DG++Y
Sbjct: 3956 TIYGWGHNHRGQLG---GIEGAKVKVPTPCEALAALRPVQLI--GGEQTLFAVTADGKLY 4010

Query: 398  TCGLNTKGQLG--HEREGNKPEQIGALADEHIVHVAC--GESHSLALSDRGQLFSWGAGS 565
              G    G+LG       + P  + ++    I  VA   G  H LALS  G+++SWG   
Sbjct: 4011 ATGYGAGGRLGVGGTESVSTPTLLESIQHVFIKKVAVNSGGKHCLALSSEGEVYSWGEAE 4070

Query: 566  DGQLGLMTTEESVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLG 745
            DG+LG          PR+I+ L    ++ V+ G  H   + A G  +TWGK  +G+LG  
Sbjct: 4071 DGKLG-HGNRSPCDRPRVIESLRGTEVVDVAAGGAHSACVTAAGDLYTWGKGRYGRLG-H 4128

Query: 746  KEFPSQASPQRVRSLEGIPLAQVAAGG--AHSFALSLSGAVFGWGMNNAGQLGLSDEEDR 919
             +   Q  P+ V +L+G  +  VA G   A +  L+    V+ WG  + G+LG    +  
Sbjct: 4129 SDSEDQLKPKLVEALQGHRVVDVACGSGDAQTLCLTDDDTVWSWGDGDYGKLGRGGSDGC 4188

Query: 920  ESPCHVKLLRAQKVVYISCGEEHTAVLTK 1006
            + P  +  L    VV + CG + +  LTK
Sbjct: 4189 KVPMKIDSLTGLGVVKVECGSQFSVALTK 4217



 Score = 21.2 bits (43), Expect(2) = 3e-24
 Identities = 9/17 (52%), Positives = 11/17 (64%)
 Frame = +1

Query: 1003 KSGGVFTFGAGSCGPLG 1053
            KSG V+T+G G    LG
Sbjct: 4217 KSGAVYTWGKGDYHRLG 4233



 Score =  107 bits (268), Expect = 1e-23
 Identities = 65/209 (31%), Positives = 110/209 (52%), Gaps = 5/209 (2%)
 Frame = +2

Query: 389  EVYTCGLNTKGQLGHEREGNK---PEQIGALADEHIVHVACGESHSLALSDRGQLFSWGA 559
            +V+  GLN K QLG  + G+K   P     L+  ++V VA G     A++  G++++ G 
Sbjct: 2961 KVFVWGLNDKDQLGGLK-GSKIKVPSFSETLSALNVVQVAGGSKSLFAVTVEGKVYACGE 3019

Query: 560  GSDGQLGLMTTEESVAVPRLIQKLNQQTILQVS--CGNWHCLALAADGQFFTWGKNSHGQ 733
             ++G+LGL  +  +V +PR I  L+   + +V+   G  H  AL  DG+ F+WG+   G+
Sbjct: 3020 ATNGRLGLGISSGTVPIPRQITALSSYVVKKVAVHSGGRHATALTVDGKVFSWGEGDDGK 3079

Query: 734  LGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEE 913
            LG          P+ + +L+   +  +A G +HS AL+ SG ++ WG+   G+LG  D  
Sbjct: 3080 LGHFSRMNCD-KPRLIEALKTKRIRDIACGSSHSAALTSSGELYTWGLGEYGRLGHGDNT 3138

Query: 914  DRESPCHVKLLRAQKVVYISCGEEHTAVL 1000
             +  P  VK+L   +V+ ++CG      L
Sbjct: 3139 TQLKPKMVKVLLGHRVIQVACGSRDAQTL 3167



 Score =  104 bits (259), Expect = 1e-22
 Identities = 70/209 (33%), Positives = 114/209 (54%), Gaps = 4/209 (1%)
 Frame = +2

Query: 239  WGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACG-GD-HSVFLLEDGEVYTCGLN 412
            WG    G+ G S +   +  +P++   +    V +VACG GD  ++ L +D  V++ G  
Sbjct: 4118 WGKGRYGRLGHSDSEDQL--KPKLVEALQGHRVVDVACGSGDAQTLCLTDDDTVWSWGDG 4175

Query: 413  TKGQLGHE-REGNK-PEQIGALADEHIVHVACGESHSLALSDRGQLFSWGAGSDGQLGLM 586
              G+LG    +G K P +I +L    +V V CG   S+AL+  G +++WG G   +LG  
Sbjct: 4176 DYGKLGRGGSDGCKVPMKIDSLTGLGVVKVECGSQFSVALTKSGAVYTWGKGDYHRLG-H 4234

Query: 587  TTEESVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQA 766
             +++ V  PR +Q L  + ++ ++ G+ HC+  + DG+ +TWG N  GQLG G     Q 
Sbjct: 4235 GSDDHVRRPRQVQGLQGKKVIAIATGSLHCVCCSEDGEVYTWGDNDEGQLGDGTTNAIQR 4294

Query: 767  SPQRVRSLEGIPLAQVAAGGAHSFALSLS 853
             P+ V +L+G  + +VA G AH+ A S S
Sbjct: 4295 -PRLVAALQGKKVNRVACGSAHTLAWSTS 4322



 Score = 97.8 bits (242), Expect = 1e-20
 Identities = 68/207 (32%), Positives = 109/207 (52%), Gaps = 4/207 (1%)
 Frame = +2

Query: 239  WGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACG-GD-HSVFLLEDGEVYTCGLN 412
            WG  + G+ G  ++    +  P +   +    V +VACG GD  ++ + E+G+V++ G  
Sbjct: 576  WGRGNYGRLGHGSSEDEAI--PMLVAGLKGLKVIDVACGSGDAQTLAVTENGQVWSWGDG 633

Query: 413  TKGQLGHE-REGNK-PEQIGALADEHIVHVACGESHSLALSDRGQLFSWGAGSDGQLGLM 586
              G+LG    +G K P+ I  L D  +V V CG   S+AL+  GQ++SWG G + +LG  
Sbjct: 634  DYGKLGRGGSDGCKTPKLIEKLQDLDVVKVRCGSQFSVALTKDGQVYSWGKGDNQRLG-H 692

Query: 587  TTEESVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQA 766
             TEE V  P+L++ L  + ++ V+ G+ HCLAL  D +  +WG N   Q        ++ 
Sbjct: 693  GTEEHVRYPKLLEGLQGKKVIDVAAGSTHCLALTEDSEVHSWGSNDQCQ-HFDTLRVTKP 751

Query: 767  SPQRVRSLEGIPLAQVAAGGAHSFALS 847
             P  +  L+   +  +A G A SFA S
Sbjct: 752  EPSALPGLDTKHIVGIACGPAQSFAWS 778



 Score = 87.8 bits (216), Expect = 1e-17
 Identities = 56/193 (29%), Positives = 91/193 (47%), Gaps = 6/193 (3%)
 Frame = +2

Query: 452  PEQIGALADEHIVHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTEESVAVPRLIQKL 631
            P Q   LA+  +  +AC E   L LS  G++++    SD              P+L+Q L
Sbjct: 443  PIQCEGLANLGVTQIACAEKRFLILSRNGRVYTQAYNSD-----------TLAPQLVQGL 491

Query: 632  NQQTILQVSCGN--WHCLALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIP- 802
              + I++++  +   H LALAA G+ ++WG    G+LG G   P +  P+ + +  G   
Sbjct: 492  ASRNIVKIAAHSDGHHYLALAATGEVYSWGCGDGGRLGHGDTVPLE-EPKVISAFSGKQA 550

Query: 803  ---LAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEEDRESPCHVKLLRAQKVVYIS 973
               +  +A G  +S A++  G ++ WG  N G+LG    ED   P  V  L+  KV+ ++
Sbjct: 551  GKHVVHIACGSTYSAAITAEGELYTWGRGNYGRLGHGSSEDEAIPMLVAGLKGLKVIDVA 610

Query: 974  CGEEHTAVLTKVE 1012
            CG      L   E
Sbjct: 611  CGSGDAQTLAVTE 623



 Score = 87.4 bits (215), Expect = 2e-17
 Identities = 48/163 (29%), Positives = 91/163 (55%), Gaps = 2/163 (1%)
 Frame = +2

Query: 521  ALSDRGQLFSWGAGSDGQLGLMTTEESVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQ 700
            A + R ++F WG     QLG +   + + VP   + L+   ++QV+ G+    A+  +G+
Sbjct: 2955 AATIRTKVFVWGLNDKDQLGGLKGSK-IKVPSFSETLSALNVVQVAGGSKSLFAVTVEGK 3013

Query: 701  FFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVA--AGGAHSFALSLSGAVFGWG 874
             +  G+ ++G+LGLG    +   P+++ +L    + +VA  +GG H+ AL++ G VF WG
Sbjct: 3014 VYACGEATNGRLGLGISSGTVPIPRQITALSSYVVKKVAVHSGGRHATALTVDGKVFSWG 3073

Query: 875  MNNAGQLGLSDEEDRESPCHVKLLRAQKVVYISCGEEHTAVLT 1003
              + G+LG     + + P  ++ L+ +++  I+CG  H+A LT
Sbjct: 3074 EGDDGKLGHFSRMNCDKPRLIEALKTKRIRDIACGSSHSAALT 3116



 Score = 79.7 bits (195), Expect = 4e-15
 Identities = 59/206 (28%), Positives = 94/206 (45%), Gaps = 5/206 (2%)
 Frame = +2

Query: 203  CMTP*RTQTMLCWG---YWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGDHSVF 373
            C+T     T+  WG   Y  LG+ G           P     ++   V +V CG   SV 
Sbjct: 4162 CLTD--DDTVWSWGDGDYGKLGRGGSDG-----CKVPMKIDSLTGLGVVKVECGSQFSVA 4214

Query: 374  LLEDGEVYTCGLNTKGQLGHEREGN--KPEQIGALADEHIVHVACGESHSLALSDRGQLF 547
            L + G VYT G     +LGH  + +  +P Q+  L  + ++ +A G  H +  S+ G+++
Sbjct: 4215 LTKSGAVYTWGKGDYHRLGHGSDDHVRRPRQVQGLQGKKVIAIATGSLHCVCCSEDGEVY 4274

Query: 548  SWGAGSDGQLGLMTTEESVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSH 727
            +WG   +GQLG  TT  ++  PRL+  L  + + +V+CG+ H LA         W  +  
Sbjct: 4275 TWGDNDEGQLGDGTTN-AIQRPRLVAALQGKKVNRVACGSAHTLA---------WSTSKP 4324

Query: 728  GQLGLGKEFPSQASPQRVRSLEGIPL 805
               G   + P Q  P     L+ IP+
Sbjct: 4325 ASAG---KLPVQV-PMEYNHLQEIPI 4346



 Score = 76.6 bits (187), Expect = 3e-14
 Identities = 50/165 (30%), Positives = 85/165 (51%), Gaps = 2/165 (1%)
 Frame = +2

Query: 515  SLALSDRGQLFSWGAGSDGQLGLMTTEESVAVPRLIQKLNQQTILQVSCGNWHCLALAAD 694
            +L+    G ++ WG    GQLG +   + V VP   + L     +Q+  G     A+ AD
Sbjct: 3948 TLSAGGSGTIYGWGHNHRGQLGGIEGAK-VKVPTPCEALAALRPVQLIGGEQTLFAVTAD 4006

Query: 695  GQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVA--AGGAHSFALSLSGAVFG 868
            G+ +  G  + G+LG+G    S ++P  + S++ + + +VA  +GG H  ALS  G V+ 
Sbjct: 4007 GKLYATGYGAGGRLGVGGT-ESVSTPTLLESIQHVFIKKVAVNSGGKHCLALSSEGEVYS 4065

Query: 869  WGMNNAGQLGLSDEEDRESPCHVKLLRAQKVVYISCGEEHTAVLT 1003
            WG    G+LG  +    + P  ++ LR  +VV ++ G  H+A +T
Sbjct: 4066 WGEAEDGKLGHGNRSPCDRPRVIESLRGTEVVDVAAGGAHSACVT 4110


>ref|XP_002685237.1| PREDICTED: hect domain and RLD 3-like [Bos taurus].
          Length = 4837

 Score =  163 bits (412), Expect = 3e-40
 Identities = 93/271 (34%), Positives = 140/271 (51%), Gaps = 4/271 (1%)
 Frame = +2

Query: 239  WGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGDHSVFLLEDGEVYTCGLNTK 418
            WG    G+ G  + +     +P++   +  + ++++ACG  HS  L   GE+YT GL   
Sbjct: 3072 WGEGDDGKLGHFSRMN--CDKPRLIEALKTKRIRDIACGSSHSAALTSSGELYTWGLGEY 3129

Query: 419  GQLGHEREGN--KPEQIGALADEHIVHVACG--ESHSLALSDRGQLFSWGAGSDGQLGLM 586
            G+LGH       KP+ +  L    ++ VACG  ++ +LAL+D G +FSWG G  G+LG  
Sbjct: 3130 GRLGHGDNTTQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFSWGDGDFGKLG-R 3188

Query: 587  TTEESVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQA 766
               E   +P+ I++LN Q + Q+ CG    LAL   G  +TWGK  + +LG G +   + 
Sbjct: 3189 GGSEGCNIPQNIERLNGQGVCQIECGAQFSLALTKSGVVWTWGKGDYFRLGHGSDVHVR- 3247

Query: 767  SPQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEEDRESPCHVKLL 946
             PQ V  L G  +  VA G  H  A++ +G V+ WG N+ GQ G         P  V+ L
Sbjct: 3248 KPQVVEGLRGKKIVHVAVGALHCLAVTDAGQVYAWGDNDHGQQGNGTTTVNRKPTLVQGL 3307

Query: 947  RAQKVVYISCGEEHTAVLTKVEVCLPLVLVP 1039
              QK+  ++CG  H+   T V+V  P V  P
Sbjct: 3308 EGQKITRVACGSSHSVAWTTVDVATPSVHEP 3338



 Score =  134 bits (336), Expect = 2e-31
 Identities = 93/262 (35%), Positives = 136/262 (51%), Gaps = 9/262 (3%)
 Frame = +2

Query: 248  WSLGQPGISTNLQGI-VAEPQVCGFISDRSVKEVACGGDHSVFLLE-DGEVYTCGLNTKG 421
            W L        L+G  +  P     +S  +V +VA GG  S+F +  +G+VY CG  T G
Sbjct: 2965 WGLNDKDQLGGLKGSKIKVPSFSETLSALNVVQVA-GGSKSLFAVTVEGKVYACGEATNG 3023

Query: 422  QLGHEREGNK---PEQIGALADEHIVHVA--CGESHSLALSDRGQLFSWGAGSDGQLGLM 586
            +LG          P QI AL+   +  VA   G  H+ AL+  G++FSWG G DG+LG  
Sbjct: 3024 RLGLGISSGTVPIPRQITALSSYVVKKVAVHSGGRHATALTVDGKVFSWGEGDDGKLGHF 3083

Query: 587  TTEESVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQA 766
             +  +   PRLI+ L  + I  ++CG+ H  AL + G+ +TWG   +G+LG G +  +Q 
Sbjct: 3084 -SRMNCDKPRLIEALKTKRIRDIACGSSHSAALTSSGELYTWGLGEYGRLGHG-DNTTQL 3141

Query: 767  SPQRVRSLEGIPLAQVAAGG--AHSFALSLSGAVFGWGMNNAGQLGLSDEEDRESPCHVK 940
             P+ V+ L G  + QVA G   A + AL+  G VF WG  + G+LG    E    P +++
Sbjct: 3142 KPKMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFSWGDGDFGKLGRGGSEGCNIPQNIE 3201

Query: 941  LLRAQKVVYISCGEEHTAVLTK 1006
             L  Q V  I CG + +  LTK
Sbjct: 3202 RLNGQGVCQIECGAQFSLALTK 3223



 Score =  132 bits (332), Expect = 5e-31
 Identities = 79/234 (33%), Positives = 120/234 (51%), Gaps = 4/234 (1%)
 Frame = +2

Query: 302  PQVCGFISDRSVKEVACGGDHSVFLLEDGEVYTCGLNTKGQLGHEREGN--KPEQIGALA 475
            P+V   +    V +VA GG HS  +   G++YT G    G+LGH    +  KP+ + AL 
Sbjct: 4085 PRVIESLRGTEVVDVAAGGAHSACVTAAGDLYTWGKGRYGRLGHSDSEDQLKPKLVEALQ 4144

Query: 476  DEHIVHVACG--ESHSLALSDRGQLFSWGAGSDGQLGLMTTEESVAVPRLIQKLNQQTIL 649
               +V VACG  ++ +L L+D   ++SWG G  G+LG     +   VP  I  L    ++
Sbjct: 4145 GHRVVDVACGSGDAQTLCLTDDDTVWSWGDGDYGKLG-RGGSDGCKVPMKIDSLTGLGVV 4203

Query: 650  QVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGA 829
            +V CG+   +AL   G  +TWGK  + +LG G +      P++V+ L+G  +  +A G  
Sbjct: 4204 KVECGSQFSVALTKSGAVYTWGKGDYHRLGHGSD-DHVRRPRQVQGLQGKKVIAIATGSL 4262

Query: 830  HSFALSLSGAVFGWGMNNAGQLGLSDEEDRESPCHVKLLRAQKVVYISCGEEHT 991
            H    S  G V+ WG N+ GQLG       + P  V  L+ +KV  ++CG  HT
Sbjct: 4263 HCVCCSEDGEVYTWGDNDEGQLGDGTTNAIQRPRLVAALQGKKVNRVACGSAHT 4316



 Score =  131 bits (330), Expect = 9e-31
 Identities = 77/245 (31%), Positives = 135/245 (55%), Gaps = 10/245 (4%)
 Frame = +2

Query: 302  PQVCGFISDRSVKEVACGGD--HSVFLLEDGEVYTCGLNTKGQLGHEREG--NKPEQIGA 469
            PQ+   ++ R++ ++A   D  H + L   GEVY+ G    G+LGH       +P+ I A
Sbjct: 485  PQLVQGLASRNIVKIAAHSDGHHYLALAATGEVYSWGCGDGGRLGHGDTVPLEEPKVISA 544

Query: 470  L----ADEHIVHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTEESVAVPRLIQKLNQ 637
                 A +H+VH+ACG ++S A++  G+L++WG G+ G+LG  ++E+  A+P L+  L  
Sbjct: 545  FSGKQAGKHVVHIACGSTYSAAITAEGELYTWGRGNYGRLGHGSSEDE-AIPMLVAGLKG 603

Query: 638  QTILQVSCGNW--HCLALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQ 811
              ++ V+CG+     LA+  +GQ ++WG   +G+LG G       +P+ +  L+ + + +
Sbjct: 604  LKVIDVACGSGDAQTLAVTENGQVWSWGDGDYGKLGRGGS-DGCKTPKLIEKLQDLDVVK 662

Query: 812  VAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEEDRESPCHVKLLRAQKVVYISCGEEHT 991
            V  G   S AL+  G V+ WG  +  +LG   EE    P  ++ L+ +KV+ ++ G  H 
Sbjct: 663  VRCGSQFSVALTKDGQVYSWGKGDNQRLGHGTEEHVRYPKLLEGLQGKKVIDVAAGSTHC 722

Query: 992  AVLTK 1006
              LT+
Sbjct: 723  LALTE 727



 Score =  125 bits (315), Expect = 5e-29
 Identities = 81/261 (31%), Positives = 131/261 (50%), Gaps = 8/261 (3%)
 Frame = +2

Query: 221  TQTMLCWGYWSLGQPGISTNLQGIVAEPQVCGFISDRS----VKEVACGGDHSVFLLEDG 388
            T  +  WG    G+ G    +   + EP+V    S +     V  +ACG  +S  +  +G
Sbjct: 514  TGEVYSWGCGDGGRLGHGDTVP--LEEPKVISAFSGKQAGKHVVHIACGSTYSAAITAEG 571

Query: 389  EVYTCGLNTKGQLGHEREGNK--PEQIGALADEHIVHVACG--ESHSLALSDRGQLFSWG 556
            E+YT G    G+LGH    ++  P  +  L    ++ VACG  ++ +LA+++ GQ++SWG
Sbjct: 572  ELYTWGRGNYGRLGHGSSEDEAIPMLVAGLKGLKVIDVACGSGDAQTLAVTENGQVWSWG 631

Query: 557  AGSDGQLGLMTTEESVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQL 736
             G  G+LG     +    P+LI+KL    +++V CG+   +AL  DGQ ++WGK  + +L
Sbjct: 632  DGDYGKLG-RGGSDGCKTPKLIEKLQDLDVVKVRCGSQFSVALTKDGQVYSWGKGDNQRL 690

Query: 737  GLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEED 916
            G G E      P+ +  L+G  +  VAAG  H  AL+    V  WG N+  Q   +    
Sbjct: 691  GHGTE-EHVRYPKLLEGLQGKKVIDVAAGSTHCLALTEDSEVHSWGSNDQCQHFDTLRVT 749

Query: 917  RESPCHVKLLRAQKVVYISCG 979
            +  P  +  L  + +V I+CG
Sbjct: 750  KPEPSALPGLDTKHIVGIACG 770



 Score =  125 bits (313), Expect = 8e-29
 Identities = 77/203 (37%), Positives = 117/203 (57%), Gaps = 5/203 (2%)
 Frame = +2

Query: 386  GEVYTCGLNTKGQLGHEREGNK---PEQIGALADEHIVHVACGESHSLALSDRGQLFSWG 556
            G +Y  G N +GQLG   EG K   P    ALA    V +  GE    A++  G+L++ G
Sbjct: 3955 GTIYGWGHNHRGQLGGI-EGAKVKVPTPCEALAALRPVQLIGGEQTLFAVTADGKLYATG 4013

Query: 557  AGSDGQLGLMTTEESVAVPRLIQKLNQQTI--LQVSCGNWHCLALAADGQFFTWGKNSHG 730
             G+ G+LG+  TE SV+ P L++ +    I  + V+ G  HCLAL+++G+ ++WG+   G
Sbjct: 4014 YGAGGRLGVGGTE-SVSTPTLLESIQHVFIKKVAVNSGGKHCLALSSEGEVYSWGEAEDG 4072

Query: 731  QLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDE 910
            +LG G   P    P+ + SL G  +  VAAGGAHS  ++ +G ++ WG    G+LG SD 
Sbjct: 4073 KLGHGNRSPCDR-PRVIESLRGTEVVDVAAGGAHSACVTAAGDLYTWGKGRYGRLGHSDS 4131

Query: 911  EDRESPCHVKLLRAQKVVYISCG 979
            ED+  P  V+ L+  +VV ++CG
Sbjct: 4132 EDQLKPKLVEALQGHRVVDVACG 4154



 Score =  118 bits (296), Expect = 8e-27
 Identities = 71/245 (28%), Positives = 127/245 (51%), Gaps = 7/245 (2%)
 Frame = +2

Query: 293  VAEPQVCGFISDRSVKEVACGGDHSVFLLEDGEVYTCGLNTKGQLGHEREGNKPEQIGAL 472
            V  P  C  +++  V ++AC     + L  +G VYT   N+        +   P+ +  L
Sbjct: 440  VIGPIQCEGLANLGVTQIACAEKRFLILSRNGRVYTQAYNS--------DTLAPQLVQGL 491

Query: 473  ADEHIVHVACGES--HSLALSDRGQLFSWGAGSDGQLG---LMTTEESVAVPRLIQKLNQ 637
            A  +IV +A      H LAL+  G+++SWG G  G+LG    +  EE   +     K   
Sbjct: 492  ASRNIVKIAAHSDGHHYLALAATGEVYSWGCGDGGRLGHGDTVPLEEPKVISAFSGKQAG 551

Query: 638  QTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVA 817
            + ++ ++CG+ +  A+ A+G+ +TWG+ ++G+LG G     +A P  V  L+G+ +  VA
Sbjct: 552  KHVVHIACGSTYSAAITAEGELYTWGRGNYGRLGHGSS-EDEAIPMLVAGLKGLKVIDVA 610

Query: 818  --AGGAHSFALSLSGAVFGWGMNNAGQLGLSDEEDRESPCHVKLLRAQKVVYISCGEEHT 991
              +G A + A++ +G V+ WG  + G+LG    +  ++P  ++ L+   VV + CG + +
Sbjct: 611  CGSGDAQTLAVTENGQVWSWGDGDYGKLGRGGSDGCKTPKLIEKLQDLDVVKVRCGSQFS 670

Query: 992  AVLTK 1006
              LTK
Sbjct: 671  VALTK 675



 Score =  109 bits (273), Expect(2) = 3e-24
 Identities = 81/269 (30%), Positives = 129/269 (47%), Gaps = 9/269 (3%)
 Frame = +2

Query: 227  TMLCWGYWSLGQPGISTNLQGI-VAEPQVCGFISD-RSVKEVACGGDHSVFLLE-DGEVY 397
            T+  WG+   GQ G    ++G  V  P  C  ++  R V+ +  GG+ ++F +  DG++Y
Sbjct: 3956 TIYGWGHNHRGQLG---GIEGAKVKVPTPCEALAALRPVQLI--GGEQTLFAVTADGKLY 4010

Query: 398  TCGLNTKGQLG--HEREGNKPEQIGALADEHIVHVAC--GESHSLALSDRGQLFSWGAGS 565
              G    G+LG       + P  + ++    I  VA   G  H LALS  G+++SWG   
Sbjct: 4011 ATGYGAGGRLGVGGTESVSTPTLLESIQHVFIKKVAVNSGGKHCLALSSEGEVYSWGEAE 4070

Query: 566  DGQLGLMTTEESVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLG 745
            DG+LG          PR+I+ L    ++ V+ G  H   + A G  +TWGK  +G+LG  
Sbjct: 4071 DGKLG-HGNRSPCDRPRVIESLRGTEVVDVAAGGAHSACVTAAGDLYTWGKGRYGRLG-H 4128

Query: 746  KEFPSQASPQRVRSLEGIPLAQVAAGG--AHSFALSLSGAVFGWGMNNAGQLGLSDEEDR 919
             +   Q  P+ V +L+G  +  VA G   A +  L+    V+ WG  + G+LG    +  
Sbjct: 4129 SDSEDQLKPKLVEALQGHRVVDVACGSGDAQTLCLTDDDTVWSWGDGDYGKLGRGGSDGC 4188

Query: 920  ESPCHVKLLRAQKVVYISCGEEHTAVLTK 1006
            + P  +  L    VV + CG + +  LTK
Sbjct: 4189 KVPMKIDSLTGLGVVKVECGSQFSVALTK 4217



 Score = 21.2 bits (43), Expect(2) = 3e-24
 Identities = 9/17 (52%), Positives = 11/17 (64%)
 Frame = +1

Query: 1003 KSGGVFTFGAGSCGPLG 1053
            KSG V+T+G G    LG
Sbjct: 4217 KSGAVYTWGKGDYHRLG 4233



 Score =  107 bits (268), Expect = 1e-23
 Identities = 65/209 (31%), Positives = 110/209 (52%), Gaps = 5/209 (2%)
 Frame = +2

Query: 389  EVYTCGLNTKGQLGHEREGNK---PEQIGALADEHIVHVACGESHSLALSDRGQLFSWGA 559
            +V+  GLN K QLG  + G+K   P     L+  ++V VA G     A++  G++++ G 
Sbjct: 2961 KVFVWGLNDKDQLGGLK-GSKIKVPSFSETLSALNVVQVAGGSKSLFAVTVEGKVYACGE 3019

Query: 560  GSDGQLGLMTTEESVAVPRLIQKLNQQTILQVS--CGNWHCLALAADGQFFTWGKNSHGQ 733
             ++G+LGL  +  +V +PR I  L+   + +V+   G  H  AL  DG+ F+WG+   G+
Sbjct: 3020 ATNGRLGLGISSGTVPIPRQITALSSYVVKKVAVHSGGRHATALTVDGKVFSWGEGDDGK 3079

Query: 734  LGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEE 913
            LG          P+ + +L+   +  +A G +HS AL+ SG ++ WG+   G+LG  D  
Sbjct: 3080 LGHFSRMNCD-KPRLIEALKTKRIRDIACGSSHSAALTSSGELYTWGLGEYGRLGHGDNT 3138

Query: 914  DRESPCHVKLLRAQKVVYISCGEEHTAVL 1000
             +  P  VK+L   +V+ ++CG      L
Sbjct: 3139 TQLKPKMVKVLLGHRVIQVACGSRDAQTL 3167



 Score =  104 bits (259), Expect = 1e-22
 Identities = 70/209 (33%), Positives = 114/209 (54%), Gaps = 4/209 (1%)
 Frame = +2

Query: 239  WGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACG-GD-HSVFLLEDGEVYTCGLN 412
            WG    G+ G S +   +  +P++   +    V +VACG GD  ++ L +D  V++ G  
Sbjct: 4118 WGKGRYGRLGHSDSEDQL--KPKLVEALQGHRVVDVACGSGDAQTLCLTDDDTVWSWGDG 4175

Query: 413  TKGQLGHE-REGNK-PEQIGALADEHIVHVACGESHSLALSDRGQLFSWGAGSDGQLGLM 586
              G+LG    +G K P +I +L    +V V CG   S+AL+  G +++WG G   +LG  
Sbjct: 4176 DYGKLGRGGSDGCKVPMKIDSLTGLGVVKVECGSQFSVALTKSGAVYTWGKGDYHRLG-H 4234

Query: 587  TTEESVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQA 766
             +++ V  PR +Q L  + ++ ++ G+ HC+  + DG+ +TWG N  GQLG G     Q 
Sbjct: 4235 GSDDHVRRPRQVQGLQGKKVIAIATGSLHCVCCSEDGEVYTWGDNDEGQLGDGTTNAIQR 4294

Query: 767  SPQRVRSLEGIPLAQVAAGGAHSFALSLS 853
             P+ V +L+G  + +VA G AH+ A S S
Sbjct: 4295 -PRLVAALQGKKVNRVACGSAHTLAWSTS 4322



 Score = 97.8 bits (242), Expect = 1e-20
 Identities = 68/207 (32%), Positives = 109/207 (52%), Gaps = 4/207 (1%)
 Frame = +2

Query: 239  WGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACG-GD-HSVFLLEDGEVYTCGLN 412
            WG  + G+ G  ++    +  P +   +    V +VACG GD  ++ + E+G+V++ G  
Sbjct: 576  WGRGNYGRLGHGSSEDEAI--PMLVAGLKGLKVIDVACGSGDAQTLAVTENGQVWSWGDG 633

Query: 413  TKGQLGHE-REGNK-PEQIGALADEHIVHVACGESHSLALSDRGQLFSWGAGSDGQLGLM 586
              G+LG    +G K P+ I  L D  +V V CG   S+AL+  GQ++SWG G + +LG  
Sbjct: 634  DYGKLGRGGSDGCKTPKLIEKLQDLDVVKVRCGSQFSVALTKDGQVYSWGKGDNQRLG-H 692

Query: 587  TTEESVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQA 766
             TEE V  P+L++ L  + ++ V+ G+ HCLAL  D +  +WG N   Q        ++ 
Sbjct: 693  GTEEHVRYPKLLEGLQGKKVIDVAAGSTHCLALTEDSEVHSWGSNDQCQ-HFDTLRVTKP 751

Query: 767  SPQRVRSLEGIPLAQVAAGGAHSFALS 847
             P  +  L+   +  +A G A SFA S
Sbjct: 752  EPSALPGLDTKHIVGIACGPAQSFAWS 778



 Score = 87.8 bits (216), Expect = 1e-17
 Identities = 56/193 (29%), Positives = 91/193 (47%), Gaps = 6/193 (3%)
 Frame = +2

Query: 452  PEQIGALADEHIVHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTEESVAVPRLIQKL 631
            P Q   LA+  +  +AC E   L LS  G++++    SD              P+L+Q L
Sbjct: 443  PIQCEGLANLGVTQIACAEKRFLILSRNGRVYTQAYNSD-----------TLAPQLVQGL 491

Query: 632  NQQTILQVSCGN--WHCLALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIP- 802
              + I++++  +   H LALAA G+ ++WG    G+LG G   P +  P+ + +  G   
Sbjct: 492  ASRNIVKIAAHSDGHHYLALAATGEVYSWGCGDGGRLGHGDTVPLE-EPKVISAFSGKQA 550

Query: 803  ---LAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEEDRESPCHVKLLRAQKVVYIS 973
               +  +A G  +S A++  G ++ WG  N G+LG    ED   P  V  L+  KV+ ++
Sbjct: 551  GKHVVHIACGSTYSAAITAEGELYTWGRGNYGRLGHGSSEDEAIPMLVAGLKGLKVIDVA 610

Query: 974  CGEEHTAVLTKVE 1012
            CG      L   E
Sbjct: 611  CGSGDAQTLAVTE 623



 Score = 87.4 bits (215), Expect = 2e-17
 Identities = 48/163 (29%), Positives = 91/163 (55%), Gaps = 2/163 (1%)
 Frame = +2

Query: 521  ALSDRGQLFSWGAGSDGQLGLMTTEESVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQ 700
            A + R ++F WG     QLG +   + + VP   + L+   ++QV+ G+    A+  +G+
Sbjct: 2955 AATIRTKVFVWGLNDKDQLGGLKGSK-IKVPSFSETLSALNVVQVAGGSKSLFAVTVEGK 3013

Query: 701  FFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVA--AGGAHSFALSLSGAVFGWG 874
             +  G+ ++G+LGLG    +   P+++ +L    + +VA  +GG H+ AL++ G VF WG
Sbjct: 3014 VYACGEATNGRLGLGISSGTVPIPRQITALSSYVVKKVAVHSGGRHATALTVDGKVFSWG 3073

Query: 875  MNNAGQLGLSDEEDRESPCHVKLLRAQKVVYISCGEEHTAVLT 1003
              + G+LG     + + P  ++ L+ +++  I+CG  H+A LT
Sbjct: 3074 EGDDGKLGHFSRMNCDKPRLIEALKTKRIRDIACGSSHSAALT 3116



 Score = 79.7 bits (195), Expect = 4e-15
 Identities = 59/206 (28%), Positives = 94/206 (45%), Gaps = 5/206 (2%)
 Frame = +2

Query: 203  CMTP*RTQTMLCWG---YWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGDHSVF 373
            C+T     T+  WG   Y  LG+ G           P     ++   V +V CG   SV 
Sbjct: 4162 CLTD--DDTVWSWGDGDYGKLGRGGSDG-----CKVPMKIDSLTGLGVVKVECGSQFSVA 4214

Query: 374  LLEDGEVYTCGLNTKGQLGHEREGN--KPEQIGALADEHIVHVACGESHSLALSDRGQLF 547
            L + G VYT G     +LGH  + +  +P Q+  L  + ++ +A G  H +  S+ G+++
Sbjct: 4215 LTKSGAVYTWGKGDYHRLGHGSDDHVRRPRQVQGLQGKKVIAIATGSLHCVCCSEDGEVY 4274

Query: 548  SWGAGSDGQLGLMTTEESVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSH 727
            +WG   +GQLG  TT  ++  PRL+  L  + + +V+CG+ H LA         W  +  
Sbjct: 4275 TWGDNDEGQLGDGTTN-AIQRPRLVAALQGKKVNRVACGSAHTLA---------WSTSKP 4324

Query: 728  GQLGLGKEFPSQASPQRVRSLEGIPL 805
               G   + P Q  P     L+ IP+
Sbjct: 4325 ASAG---KLPVQV-PMEYNHLQEIPI 4346



 Score = 76.6 bits (187), Expect = 3e-14
 Identities = 50/165 (30%), Positives = 85/165 (51%), Gaps = 2/165 (1%)
 Frame = +2

Query: 515  SLALSDRGQLFSWGAGSDGQLGLMTTEESVAVPRLIQKLNQQTILQVSCGNWHCLALAAD 694
            +L+    G ++ WG    GQLG +   + V VP   + L     +Q+  G     A+ AD
Sbjct: 3948 TLSAGGSGTIYGWGHNHRGQLGGIEGAK-VKVPTPCEALAALRPVQLIGGEQTLFAVTAD 4006

Query: 695  GQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVA--AGGAHSFALSLSGAVFG 868
            G+ +  G  + G+LG+G    S ++P  + S++ + + +VA  +GG H  ALS  G V+ 
Sbjct: 4007 GKLYATGYGAGGRLGVGGT-ESVSTPTLLESIQHVFIKKVAVNSGGKHCLALSSEGEVYS 4065

Query: 869  WGMNNAGQLGLSDEEDRESPCHVKLLRAQKVVYISCGEEHTAVLT 1003
            WG    G+LG  +    + P  ++ LR  +VV ++ G  H+A +T
Sbjct: 4066 WGEAEDGKLGHGNRSPCDRPRVIESLRGTEVVDVAAGGAHSACVT 4110


>ref|NP_001095465.1| probable E3 ubiquitin-protein ligase HERC5 [Bos taurus].
          Length = 958

 Score =  143 bits (361), Expect(2) = 9e-36
 Identities = 72/168 (42%), Positives = 106/168 (63%)
 Frame = +2

Query: 503  GESHSLALSDRGQLFSWGAGSDGQLGLMTTEESVAVPRLIQKLNQQTILQVSCGNWHCLA 682
            GE H L LS  G+ F +             + S+   R    L ++ I+Q++CG++H LA
Sbjct: 115  GEEHMLVLSSDGKPFEY-------------KYSIEHARFQCILQEKNIIQITCGDYHSLA 161

Query: 683  LAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLSGAV 862
            L+  G+ F WG+N  GQLG+G+ F S ++P+ V +L G+PL Q++AG AHS ALS+SG V
Sbjct: 162  LSKGGELFAWGQNLDGQLGVGRIFASTSTPEIVENLSGVPLVQISAGEAHSMALSMSGNV 221

Query: 863  FGWGMNNAGQLGLSDEEDRESPCHVKLLRAQKVVYISCGEEHTAVLTK 1006
            + WG N+ GQLGL    ++ESP  ++ L  QKV +++CG  HTA+LTK
Sbjct: 222  YSWGRNDCGQLGLGHTYNKESPSCIEALDDQKVEFLACGGCHTALLTK 269



 Score = 25.8 bits (55), Expect(2) = 9e-36
 Identities = 12/17 (70%), Positives = 12/17 (70%)
 Frame = +1

Query: 1003 KSGGVFTFGAGSCGPLG 1053
            KSG VFTFG G  G LG
Sbjct: 269  KSGLVFTFGDGKYGQLG 285



 Score =  132 bits (331), Expect(2) = 3e-31
 Identities = 74/236 (31%), Positives = 124/236 (52%), Gaps = 1/236 (0%)
 Frame = +2

Query: 287 GIVAEPQVCGFISDRSVKEVACGGDHSVFLLEDGEVYTCGLNTKGQLGHEREGNKPEQIG 466
           G+       G    R  K +  G    +  ++ GE +   L++ G+    +   +  +  
Sbjct: 82  GVEVHQLPAGSDGARKPKCIKLGKKMKIHSMDQGEEHMLVLSSDGKPFEYKYSIEHARFQ 141

Query: 467 ALADE-HIVHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTEESVAVPRLIQKLNQQT 643
            +  E +I+ + CG+ HSLALS  G+LF+WG   DGQLG+     S + P +++ L+   
Sbjct: 142 CILQEKNIIQITCGDYHSLALSKGGELFAWGQNLDGQLGVGRIFASTSTPEIVENLSGVP 201

Query: 644 ILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAG 823
           ++Q+S G  H +AL+  G  ++WG+N  GQLGLG  + ++ SP  + +L+   +  +A G
Sbjct: 202 LVQISAGEAHSMALSMSGNVYSWGRNDCGQLGLGHTY-NKESPSCIEALDDQKVEFLACG 260

Query: 824 GAHSFALSLSGAVFGWGMNNAGQLGLSDEEDRESPCHVKLLRAQKVVYISCGEEHT 991
           G H+  L+ SG VF +G    GQLG +  ++   P  V  L   +V  I+CG +HT
Sbjct: 261 GCHTALLTKSGLVFTFGDGKYGQLGHNSTQNELRPRLVTGLVGNRVTQIACGRQHT 316



 Score = 22.3 bits (46), Expect(2) = 3e-31
 Identities = 9/16 (56%), Positives = 12/16 (75%)
 Frame = +1

Query: 1006 SGGVFTFGAGSCGPLG 1053
            +G VF+FG+G  G LG
Sbjct: 323  TGKVFSFGSGKEGQLG 338



 Score =  120 bits (301), Expect = 2e-27
 Identities = 73/218 (33%), Positives = 118/218 (54%), Gaps = 4/218 (1%)
 Frame = +2

Query: 320 ISDRSVKEVACGGDHSVFLLEDGEVYTCGLNTKGQLGHER---EGNKPEQIGALADEHIV 490
           + ++++ ++ CG  HS+ L + GE++  G N  GQLG  R     + PE +  L+   +V
Sbjct: 144 LQEKNIIQITCGDYHSLALSKGGELFAWGQNLDGQLGVGRIFASTSTPEIVENLSGVPLV 203

Query: 491 HVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTEESVAVPRLIQKLNQQTILQVSCGNW 670
            ++ GE+HS+ALS  G ++SWG    GQLGL  T    + P  I+ L+ Q +  ++CG  
Sbjct: 204 QISAGEAHSMALSMSGNVYSWGRNDCGQLGLGHTYNKES-PSCIEALDDQKVEFLACGGC 262

Query: 671 HCLALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFA-LS 847
           H   L   G  FT+G   +GQLG      ++  P+ V  L G  + Q+A G  H+ A +S
Sbjct: 263 HTALLTKSGLVFTFGDGKYGQLGHNST-QNELRPRLVTGLVGNRVTQIACGRQHTLAYVS 321

Query: 848 LSGAVFGWGMNNAGQLGLSDEEDRESPCHVKLLRAQKV 961
            +G VF +G    GQLG     ++  P  +KLL ++++
Sbjct: 322 DTGKVFSFGSGKEGQLGNGGTRNQLIPRPMKLLSSEEL 359



 Score = 85.5 bits (210), Expect = 7e-17
 Identities = 54/179 (30%), Positives = 88/179 (49%), Gaps = 5/179 (2%)
 Frame = +2

Query: 239 WGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGDHSVFLLEDGEVYTCGLNTK 418
           WG    GQ G+          P     + D+ V+ +ACGG H+  L + G V+T G    
Sbjct: 224 WGRNDCGQLGLGHTYNK--ESPSCIEALDDQKVEFLACGGCHTALLTKSGLVFTFGDGKY 281

Query: 419 GQLGHEREGN--KPEQIGALADEHIVHVACGESHSLA-LSDRGQLFSWGAGSDGQLGLMT 589
           GQLGH    N  +P  +  L    +  +ACG  H+LA +SD G++FS+G+G +GQLG   
Sbjct: 282 GQLGHNSTQNELRPRLVTGLVGNRVTQIACGRQHTLAYVSDTGKVFSFGSGKEGQLGNGG 341

Query: 590 TEESVAVPRLIQKLNQQTILQVSCGNWHCLALAADG--QFFTWGKNSHGQLGLGKEFPS 760
           T   + +PR ++ L+ + +   S  +   L + A G      W +  +  + L ++ P+
Sbjct: 342 TRNQL-IPRPMKLLSSEELKSESSTSVKELIMVAGGNQSILIWMEKENSYVNLRRKIPT 399


>ref|NP_001179920.1| RCC1 and BTB domain-containing protein 2 [Bos taurus].
          Length = 527

 Score =  143 bits (361), Expect = 2e-34
 Identities = 85/254 (33%), Positives = 134/254 (52%), Gaps = 12/254 (4%)
 Frame = +2

Query: 269 ISTNLQGIVAEPQVCGFISDR-----SVKEVAC----GGDHSVFLLEDGEVYTCGLNTKG 421
           + TN  G +    V   I  R     S K++AC     G H V    +GEV+T G N   
Sbjct: 46  LGTNCCGCLGLGDVQSTIEPRRLDSLSGKKIACLSYGSGPHIVLATTEGEVFTWGHNAYS 105

Query: 422 QLGH--EREGNKPEQIGA-LADEHIVHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTT 592
           QLG+     G  P  I   L+++ ++ VACG  HSL L+  G++F+WG  + GQ+G  +T
Sbjct: 106 QLGNGTTNAGLVPYHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGST 165

Query: 593 EESVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQASP 772
                  R+   L  + ++ ++CG    +A+   G+ F WG N +GQLGLG    +Q +P
Sbjct: 166 ANQPIPRRVTGCLQSKVVVNIACGQMCSMAVVNTGEVFVWGYNGNGQLGLGSS-GNQPTP 224

Query: 773 QRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEEDRESPCHVKLLRA 952
            RV +L+GI + +VA G AH+  L+  G V+ WG N+ GQLG  ++ ++  P  V + + 
Sbjct: 225 CRVAALQGIRVQRVACGYAHTLVLTDEGQVYAWGANSYGQLGTGNKSNQSYPTPVVVEKD 284

Query: 953 QKVVYISCGEEHTA 994
           + +   +C   HT+
Sbjct: 285 RIIEIAACHSAHTS 298



 Score =  123 bits (308), Expect = 3e-28
 Identities = 69/209 (33%), Positives = 114/209 (54%), Gaps = 4/209 (1%)
 Frame = +2

Query: 389  EVYTCGLNTKG--QLGHEREGNKPEQIGALADEHIVHVACGES-HSLALSDRGQLFSWGA 559
            E++  G N  G   LG  +   +P ++ +L+ + I  ++ G   H +  +  G++F+WG 
Sbjct: 42   EIFVLGTNCCGCLGLGDVQSTIEPRRLDSLSGKKIACLSYGSGPHIVLATTEGEVFTWGH 101

Query: 560  GSDGQLGLMTTEESVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLG 739
             +  QLG  TT   +    +   L+ + +++V+CG++H L L +DG+ F WG N+ GQ+G
Sbjct: 102  NAYSQLGNGTTNAGLVPYHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVG 161

Query: 740  LGKEFPSQASPQRVRS-LEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEED 916
             G    +Q  P+RV   L+   +  +A G   S A+  +G VF WG N  GQLGL    +
Sbjct: 162  SGST-ANQPIPRRVTGCLQSKVVVNIACGQMCSMAVVNTGEVFVWGYNGNGQLGLGSSGN 220

Query: 917  RESPCHVKLLRAQKVVYISCGEEHTAVLT 1003
            + +PC V  L+  +V  ++CG  HT VLT
Sbjct: 221  QPTPCRVAALQGIRVQRVACGYAHTLVLT 249


  Database: RefSeq49_BP.fasta
    Posted date:  Oct 17, 2011  1:42 PM
  Number of letters in database: 17,681,374
  Number of sequences in database:  33,088
  
Lambda     K      H
   0.318    0.134    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 33088
Number of Hits to DB: 49,640,857
Number of extensions: 1610863
Number of successful extensions: 8587
Number of sequences better than 1.0e-05: 32
Number of HSP's gapped: 8069
Number of HSP's successfully gapped: 164
Length of query: 351
Length of database: 17,681,374
Length adjustment: 103
Effective length of query: 248
Effective length of database: 14,273,310
Effective search space: 3539780880
Effective search space used: 3539780880
Neighboring words threshold: 12
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 34 (17.7 bits)

BLASTX 2.2.24 [Aug-08-2010]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= 20110601C-003003
         (1053 letters)

Database: RefSeq49_CP.fasta 
           33,336 sequences; 18,874,504 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

Alignment   gi|XP_535653.2| PREDICTED: similar to HECT domain and RCC1-like...   522   e-152
Alignment   gi|XP_860006.1| PREDICTED: similar to hect domain and RLD 4 iso...   311   3e-87
Alignment   gi|XP_849808.1| PREDICTED: similar to hect domain and RLD 4 iso...   304   3e-85
Alignment   gi|XP_860046.1| PREDICTED: similar to hect domain and RLD 4 iso...   304   3e-85
Alignment   gi|XP_536367.2| PREDICTED: similar to hect domain and RLD 4 iso...   304   3e-85
Alignment   gi|XP_859968.1| PREDICTED: similar to hect domain and RLD 4 iso...   304   3e-85
Alignment   gi|XP_859933.1| PREDICTED: similar to hect domain and RLD 4 iso...   304   3e-85
Alignment   gi|XP_859900.1| PREDICTED: similar to hect domain and RLD 4 iso...   304   3e-85
Alignment   gi|XP_859760.1| PREDICTED: similar to hect domain and RLD 4 iso...   304   3e-85
Alignment   gi|XP_859830.1| PREDICTED: similar to hect domain and RLD 4 iso...   304   3e-85

>ref|XP_535653.2| PREDICTED: similar to HECT domain and RCC1-like domain protein 3
            [Canis familiaris].
          Length = 1051

 Score =  522 bits (1344), Expect(2) = e-152
 Identities = 253/260 (97%), Positives = 258/260 (99%), Gaps = 1/260 (0%)
 Frame = +2

Query: 230  MLCWGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGDHSVFLLEDGEVYTCGL 409
            MLCWGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGG+HSVFLLEDGEVYTCGL
Sbjct: 1    MLCWGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGNHSVFLLEDGEVYTCGL 60

Query: 410  NTKGQLGHEREGNKPEQIGALADEHIVHVACGESHSLALSDRGQLFSWGAGSDGQLGLMT 589
            NTKGQLGHEREGNKPEQIGALAD+HIVHVACGESHSLALSDRGQLFSWGAGSDGQLGLMT
Sbjct: 61   NTKGQLGHEREGNKPEQIGALADQHIVHVACGESHSLALSDRGQLFSWGAGSDGQLGLMT 120

Query: 590  TEESVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQAS 769
            TE+SVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKE+PSQAS
Sbjct: 121  TEDSVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEYPSQAS 180

Query: 770  PQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEE-DRESPCHVKLL 946
            PQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEE +RESPCHVKLL
Sbjct: 181  PQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEEGNRESPCHVKLL 240

Query: 947  RAQKVVYISCGEEHTAVLTK 1006
            R QKVVYISCGEEHTAVLTK
Sbjct: 241  RTQKVVYISCGEEHTAVLTK 260



 Score = 37.7 bits (86), Expect(2) = e-152
 Identities = 16/17 (94%), Positives = 16/17 (94%)
 Frame = +1

Query: 1003 KSGGVFTFGAGSCGPLG 1053
            KSGGVFTFGAGSCG LG
Sbjct: 260  KSGGVFTFGAGSCGQLG 276



 Score =  132 bits (333), Expect = 4e-31
 Identities = 82/241 (34%), Positives = 126/241 (52%), Gaps = 4/241 (1%)
 Frame = +2

Query: 230 MLCWGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGDHSVFLLEDGEVYTCGL 409
           +  WG  S GQ G+ T  +  VA P++   ++ +++ +V+CG  H + L  DG+ +T G 
Sbjct: 105 LFSWGAGSDGQLGLMTT-EDSVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGK 163

Query: 410 NTKGQLGHERE---GNKPEQIGALADEHIVHVACGESHSLALSDRGQLFSWGAGSDGQLG 580
           N+ GQLG  +E      P+++ +L    +  VA G +HS ALS  G +F WG  + GQLG
Sbjct: 164 NSHGQLGLGKEYPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLG 223

Query: 581 LMTTEESVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPS 760
           L   E +   P  ++ L  Q ++ +SCG  H   L   G  FT+G  S GQLG       
Sbjct: 224 LSDEEGNRESPCHVKLLRTQKVVYISCGEEHTAVLTKSGGVFTFGAGSCGQLG-HDSMND 282

Query: 761 QASPQRVRSLEGIPLAQVAAGGAHSFA-LSLSGAVFGWGMNNAGQLGLSDEEDRESPCHV 937
           + +P+RV  L G  + Q+A G  H+ A +  SG ++ +G    GQLG     + + P  V
Sbjct: 283 EVNPRRVLELMGSEVTQIACGRQHTLAFVPSSGLIYAFGCGAKGQLGTGHTCNVKCPSPV 342

Query: 938 K 940
           K
Sbjct: 343 K 343


>ref|XP_860006.1| PREDICTED: similar to hect domain and RLD 4 isoform a isoform 9
            [Canis familiaris].
          Length = 1054

 Score =  311 bits (796), Expect(2) = 3e-87
 Identities = 149/259 (57%), Positives = 193/259 (74%)
 Frame = +2

Query: 230  MLCWGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGDHSVFLLEDGEVYTCGL 409
            MLCWG  S GQ G+    + IV EP+   F  ++ V++V CG  H+VF+L+DG VYTCG 
Sbjct: 1    MLCWGNASFGQLGLGGIDEEIVLEPRKSDFFINKKVRDVGCGLRHTVFVLDDGTVYTCGC 60

Query: 410  NTKGQLGHEREGNKPEQIGALADEHIVHVACGESHSLALSDRGQLFSWGAGSDGQLGLMT 589
            N  GQLGHE+   KPEQ+ AL  ++IV V+CGE+H+LAL+D+GQ+++WG  SDGQLGL+ 
Sbjct: 61   NDLGQLGHEKSRKKPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGLLG 120

Query: 590  TEESVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQAS 769
            +EE + VPR I+ L+   I+QV+CG +H LAL+ +G+FF WG+N +GQLGLG +   QAS
Sbjct: 121  SEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKEGEFFCWGQNKYGQLGLGIDCKKQAS 180

Query: 770  PQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEEDRESPCHVKLLR 949
            PQ ++SL GIP  QVAAGGAHSF L+LSGA+FGWG N  GQLGL+DE DR  P  +K LR
Sbjct: 181  PQLIKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLR 240

Query: 950  AQKVVYISCGEEHTAVLTK 1006
             QK+VYI CGE+HTA LTK
Sbjct: 241  TQKIVYICCGEDHTAALTK 259



 Score = 30.4 bits (67), Expect(2) = 3e-87
 Identities = 13/17 (76%), Positives = 13/17 (76%)
 Frame = +1

Query: 1003 KSGGVFTFGAGSCGPLG 1053
            K GGVFTFGAG  G LG
Sbjct: 259  KEGGVFTFGAGGYGQLG 275



 Score =  101 bits (252), Expect = 1e-21
 Identities = 68/219 (31%), Positives = 108/219 (49%), Gaps = 17/219 (7%)
 Frame = +2

Query: 236 CWGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGDHSVFLLEDGEVYTCGLNT 415
           CWG    GQ G+  + +   A PQ+   +      +VA GG HS  L   G ++  G N 
Sbjct: 160 CWGQNKYGQLGLGIDCKK-QASPQLIKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNK 218

Query: 416 KGQLGHEREGNK--PEQIGALADEHIVHVACGESHSLALSDRGQLFSWGAGSDGQLGLMT 589
            GQLG   E ++  P  + +L  + IV++ CGE H+ AL+  G +F++GAG  GQLG  +
Sbjct: 219 FGQLGLNDENDRYVPNLLKSLRTQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNS 278

Query: 590 TEESVAVPRLIQKLNQQTILQVSCGNWHCLA-LAADGQFFTWGKNSHGQLGLGKE----- 751
           T   +  PR + +L    + Q++CG  H  A + + G+ +++G   +GQLG G       
Sbjct: 279 TSHEIN-PRKVFELMGSIVTQIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRKS 337

Query: 752 --------FPSQAS-PQRVRSLEGIPLAQVAAGGAHSFA 841
                   FP     P  + S E   + ++ +GG  SF+
Sbjct: 338 PFTVKGNWFPYNGQCPPDIDSEEYFCVKRIFSGGDQSFS 376


>ref|XP_849808.1| PREDICTED: similar to hect domain and RLD 4 isoform a isoform 2
            [Canis familiaris].
          Length = 1057

 Score =  304 bits (779), Expect(2) = 3e-85
 Identities = 147/259 (56%), Positives = 190/259 (73%)
 Frame = +2

Query: 230  MLCWGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGDHSVFLLEDGEVYTCGL 409
            MLCWG  S GQ G+    + IV EP+   F  ++ V++V CG  H+VF+L+DG VYTCG 
Sbjct: 1    MLCWGNASFGQLGLGGIDEEIVLEPRKSDFFINKKVRDVGCGLRHTVFVLDDGTVYTCGC 60

Query: 410  NTKGQLGHEREGNKPEQIGALADEHIVHVACGESHSLALSDRGQLFSWGAGSDGQLGLMT 589
            N  GQLGHE+   KPEQ+ AL  ++IV V+CGE+H+LAL+D+GQ+++WG  SDGQLGL+ 
Sbjct: 61   NDLGQLGHEKSRKKPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGLLG 120

Query: 590  TEESVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQAS 769
            +EE + VPR I+ L+   I+QV+CG +H LAL+   + F WG+N +GQLGLG +   QAS
Sbjct: 121  SEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGIDCKKQAS 180

Query: 770  PQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEEDRESPCHVKLLR 949
            PQ ++SL GIP  QVAAGGAHSF L+LSGA+FGWG N  GQLGL+DE DR  P  +K LR
Sbjct: 181  PQLIKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLR 240

Query: 950  AQKVVYISCGEEHTAVLTK 1006
             QK+VYI CGE+HTA LTK
Sbjct: 241  TQKIVYICCGEDHTAALTK 259



 Score = 30.4 bits (67), Expect(2) = 3e-85
 Identities = 13/17 (76%), Positives = 13/17 (76%)
 Frame = +1

Query: 1003 KSGGVFTFGAGSCGPLG 1053
            K GGVFTFGAG  G LG
Sbjct: 259  KEGGVFTFGAGGYGQLG 275



 Score =  127 bits (318), Expect = 2e-29
 Identities = 84/238 (35%), Positives = 123/238 (51%), Gaps = 4/238 (1%)
 Frame = +2

Query: 239 WGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGDHSVFLLEDGEVYTCGLNTK 418
           WG  S GQ G+  + +  +  P+    +SD  + +VACG  HS+ L +  EV+  G N  
Sbjct: 108 WGLDSDGQLGLLGS-EECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKY 166

Query: 419 GQLGHEREGNK---PEQIGALADEHIVHVACGESHSLALSDRGQLFSWGAGSDGQLGLMT 589
           GQLG   +  K   P+ I +L     + VA G +HS  L+  G +F WG    GQLGL  
Sbjct: 167 GQLGLGIDCKKQASPQLIKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGL-N 225

Query: 590 TEESVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQAS 769
            E    VP L++ L  Q I+ + CG  H  AL  +G  FT+G   +GQLG       + +
Sbjct: 226 DENDRYVPNLLKSLRTQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNST-SHEIN 284

Query: 770 PQRVRSLEGIPLAQVAAGGAHSFA-LSLSGAVFGWGMNNAGQLGLSDEEDRESPCHVK 940
           P++V  L G  + Q+A G  H+ A +  SG ++ +G+   GQLG     +R+SP  VK
Sbjct: 285 PRKVFELMGSIVTQIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRKSPFTVK 342



 Score =  102 bits (254), Expect = 6e-22
 Identities = 68/225 (30%), Positives = 110/225 (48%), Gaps = 17/225 (7%)
 Frame = +2

Query: 218 RTQTMLCWGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGDHSVFLLEDGEVY 397
           +   + CWG    GQ G+  + +   A PQ+   +      +VA GG HS  L   G ++
Sbjct: 154 KASEVFCWGQNKYGQLGLGIDCKK-QASPQLIKSLLGIPFMQVAAGGAHSFVLTLSGAIF 212

Query: 398 TCGLNTKGQLGHEREGNK--PEQIGALADEHIVHVACGESHSLALSDRGQLFSWGAGSDG 571
             G N  GQLG   E ++  P  + +L  + IV++ CGE H+ AL+  G +F++GAG  G
Sbjct: 213 GWGRNKFGQLGLNDENDRYVPNLLKSLRTQKIVYICCGEDHTAALTKEGGVFTFGAGGYG 272

Query: 572 QLGLMTTEESVAVPRLIQKLNQQTILQVSCGNWHCLA-LAADGQFFTWGKNSHGQLGLGK 748
           QLG  +T   +  PR + +L    + Q++CG  H  A + + G+ +++G   +GQLG G 
Sbjct: 273 QLGHNSTSHEIN-PRKVFELMGSIVTQIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGS 331

Query: 749 E-------------FPSQAS-PQRVRSLEGIPLAQVAAGGAHSFA 841
                         FP     P  + S E   + ++ +GG  SF+
Sbjct: 332 TSNRKSPFTVKGNWFPYNGQCPPDIDSEEYFCVKRIFSGGDQSFS 376


>ref|XP_860046.1| PREDICTED: similar to hect domain and RLD 4 isoform b isoform 10
            [Canis familiaris].
          Length = 1055

 Score =  304 bits (779), Expect(2) = 3e-85
 Identities = 147/259 (56%), Positives = 190/259 (73%)
 Frame = +2

Query: 230  MLCWGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGDHSVFLLEDGEVYTCGL 409
            MLCWG  S GQ G+    + IV EP+   F  ++ V++V CG  H+VF+L+DG VYTCG 
Sbjct: 1    MLCWGNASFGQLGLGGIDEEIVLEPRKSDFFINKKVRDVGCGLRHTVFVLDDGTVYTCGC 60

Query: 410  NTKGQLGHEREGNKPEQIGALADEHIVHVACGESHSLALSDRGQLFSWGAGSDGQLGLMT 589
            N  GQLGHE+   KPEQ+ AL  ++IV V+CGE+H+LAL+D+GQ+++WG  SDGQLGL+ 
Sbjct: 61   NDLGQLGHEKSRKKPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGLLG 120

Query: 590  TEESVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQAS 769
            +EE + VPR I+ L+   I+QV+CG +H LAL+   + F WG+N +GQLGLG +   QAS
Sbjct: 121  SEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGIDCKKQAS 180

Query: 770  PQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEEDRESPCHVKLLR 949
            PQ ++SL GIP  QVAAGGAHSF L+LSGA+FGWG N  GQLGL+DE DR  P  +K LR
Sbjct: 181  PQLIKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLR 240

Query: 950  AQKVVYISCGEEHTAVLTK 1006
             QK+VYI CGE+HTA LTK
Sbjct: 241  TQKIVYICCGEDHTAALTK 259



 Score = 30.4 bits (67), Expect(2) = 3e-85
 Identities = 13/17 (76%), Positives = 13/17 (76%)
 Frame = +1

Query: 1003 KSGGVFTFGAGSCGPLG 1053
            K GGVFTFGAG  G LG
Sbjct: 259  KEGGVFTFGAGGYGQLG 275



 Score =  127 bits (318), Expect = 2e-29
 Identities = 84/238 (35%), Positives = 123/238 (51%), Gaps = 4/238 (1%)
 Frame = +2

Query: 239 WGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGDHSVFLLEDGEVYTCGLNTK 418
           WG  S GQ G+  + +  +  P+    +SD  + +VACG  HS+ L +  EV+  G N  
Sbjct: 108 WGLDSDGQLGLLGS-EECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKY 166

Query: 419 GQLGHEREGNK---PEQIGALADEHIVHVACGESHSLALSDRGQLFSWGAGSDGQLGLMT 589
           GQLG   +  K   P+ I +L     + VA G +HS  L+  G +F WG    GQLGL  
Sbjct: 167 GQLGLGIDCKKQASPQLIKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGL-N 225

Query: 590 TEESVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQAS 769
            E    VP L++ L  Q I+ + CG  H  AL  +G  FT+G   +GQLG       + +
Sbjct: 226 DENDRYVPNLLKSLRTQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNST-SHEIN 284

Query: 770 PQRVRSLEGIPLAQVAAGGAHSFA-LSLSGAVFGWGMNNAGQLGLSDEEDRESPCHVK 940
           P++V  L G  + Q+A G  H+ A +  SG ++ +G+   GQLG     +R+SP  VK
Sbjct: 285 PRKVFELMGSIVTQIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRKSPFTVK 342



 Score =  102 bits (254), Expect = 6e-22
 Identities = 68/225 (30%), Positives = 110/225 (48%), Gaps = 17/225 (7%)
 Frame = +2

Query: 218 RTQTMLCWGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGDHSVFLLEDGEVY 397
           +   + CWG    GQ G+  + +   A PQ+   +      +VA GG HS  L   G ++
Sbjct: 154 KASEVFCWGQNKYGQLGLGIDCKK-QASPQLIKSLLGIPFMQVAAGGAHSFVLTLSGAIF 212

Query: 398 TCGLNTKGQLGHEREGNK--PEQIGALADEHIVHVACGESHSLALSDRGQLFSWGAGSDG 571
             G N  GQLG   E ++  P  + +L  + IV++ CGE H+ AL+  G +F++GAG  G
Sbjct: 213 GWGRNKFGQLGLNDENDRYVPNLLKSLRTQKIVYICCGEDHTAALTKEGGVFTFGAGGYG 272

Query: 572 QLGLMTTEESVAVPRLIQKLNQQTILQVSCGNWHCLA-LAADGQFFTWGKNSHGQLGLGK 748
           QLG  +T   +  PR + +L    + Q++CG  H  A + + G+ +++G   +GQLG G 
Sbjct: 273 QLGHNSTSHEIN-PRKVFELMGSIVTQIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGS 331

Query: 749 E-------------FPSQAS-PQRVRSLEGIPLAQVAAGGAHSFA 841
                         FP     P  + S E   + ++ +GG  SF+
Sbjct: 332 TSNRKSPFTVKGNWFPYNGQCPPDIDSEEYFCVKRIFSGGDQSFS 376


>ref|XP_536367.2| PREDICTED: similar to hect domain and RLD 4 isoform b isoform 1
            [Canis familiaris].
          Length = 1049

 Score =  304 bits (779), Expect(2) = 3e-85
 Identities = 147/259 (56%), Positives = 190/259 (73%)
 Frame = +2

Query: 230  MLCWGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGDHSVFLLEDGEVYTCGL 409
            MLCWG  S GQ G+    + IV EP+   F  ++ V++V CG  H+VF+L+DG VYTCG 
Sbjct: 1    MLCWGNASFGQLGLGGIDEEIVLEPRKSDFFINKKVRDVGCGLRHTVFVLDDGTVYTCGC 60

Query: 410  NTKGQLGHEREGNKPEQIGALADEHIVHVACGESHSLALSDRGQLFSWGAGSDGQLGLMT 589
            N  GQLGHE+   KPEQ+ AL  ++IV V+CGE+H+LAL+D+GQ+++WG  SDGQLGL+ 
Sbjct: 61   NDLGQLGHEKSRKKPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGLLG 120

Query: 590  TEESVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQAS 769
            +EE + VPR I+ L+   I+QV+CG +H LAL+   + F WG+N +GQLGLG +   QAS
Sbjct: 121  SEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGIDCKKQAS 180

Query: 770  PQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEEDRESPCHVKLLR 949
            PQ ++SL GIP  QVAAGGAHSF L+LSGA+FGWG N  GQLGL+DE DR  P  +K LR
Sbjct: 181  PQLIKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLR 240

Query: 950  AQKVVYISCGEEHTAVLTK 1006
             QK+VYI CGE+HTA LTK
Sbjct: 241  TQKIVYICCGEDHTAALTK 259



 Score = 30.4 bits (67), Expect(2) = 3e-85
 Identities = 13/17 (76%), Positives = 13/17 (76%)
 Frame = +1

Query: 1003 KSGGVFTFGAGSCGPLG 1053
            K GGVFTFGAG  G LG
Sbjct: 259  KEGGVFTFGAGGYGQLG 275



 Score =  127 bits (318), Expect = 2e-29
 Identities = 84/238 (35%), Positives = 123/238 (51%), Gaps = 4/238 (1%)
 Frame = +2

Query: 239 WGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGDHSVFLLEDGEVYTCGLNTK 418
           WG  S GQ G+  + +  +  P+    +SD  + +VACG  HS+ L +  EV+  G N  
Sbjct: 108 WGLDSDGQLGLLGS-EECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKY 166

Query: 419 GQLGHEREGNK---PEQIGALADEHIVHVACGESHSLALSDRGQLFSWGAGSDGQLGLMT 589
           GQLG   +  K   P+ I +L     + VA G +HS  L+  G +F WG    GQLGL  
Sbjct: 167 GQLGLGIDCKKQASPQLIKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGL-N 225

Query: 590 TEESVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQAS 769
            E    VP L++ L  Q I+ + CG  H  AL  +G  FT+G   +GQLG       + +
Sbjct: 226 DENDRYVPNLLKSLRTQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNST-SHEIN 284

Query: 770 PQRVRSLEGIPLAQVAAGGAHSFA-LSLSGAVFGWGMNNAGQLGLSDEEDRESPCHVK 940
           P++V  L G  + Q+A G  H+ A +  SG ++ +G+   GQLG     +R+SP  VK
Sbjct: 285 PRKVFELMGSIVTQIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRKSPFTVK 342



 Score =  102 bits (254), Expect = 6e-22
 Identities = 68/225 (30%), Positives = 110/225 (48%), Gaps = 17/225 (7%)
 Frame = +2

Query: 218 RTQTMLCWGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGDHSVFLLEDGEVY 397
           +   + CWG    GQ G+  + +   A PQ+   +      +VA GG HS  L   G ++
Sbjct: 154 KASEVFCWGQNKYGQLGLGIDCKK-QASPQLIKSLLGIPFMQVAAGGAHSFVLTLSGAIF 212

Query: 398 TCGLNTKGQLGHEREGNK--PEQIGALADEHIVHVACGESHSLALSDRGQLFSWGAGSDG 571
             G N  GQLG   E ++  P  + +L  + IV++ CGE H+ AL+  G +F++GAG  G
Sbjct: 213 GWGRNKFGQLGLNDENDRYVPNLLKSLRTQKIVYICCGEDHTAALTKEGGVFTFGAGGYG 272

Query: 572 QLGLMTTEESVAVPRLIQKLNQQTILQVSCGNWHCLA-LAADGQFFTWGKNSHGQLGLGK 748
           QLG  +T   +  PR + +L    + Q++CG  H  A + + G+ +++G   +GQLG G 
Sbjct: 273 QLGHNSTSHEIN-PRKVFELMGSIVTQIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGS 331

Query: 749 E-------------FPSQAS-PQRVRSLEGIPLAQVAAGGAHSFA 841
                         FP     P  + S E   + ++ +GG  SF+
Sbjct: 332 TSNRKSPFTVKGNWFPYNGQCPPDIDSEEYFCVKRIFSGGDQSFS 376


>ref|XP_859968.1| PREDICTED: similar to hect domain and RLD 4 isoform b isoform 8
            [Canis familiaris].
          Length = 1049

 Score =  304 bits (779), Expect(2) = 3e-85
 Identities = 147/259 (56%), Positives = 190/259 (73%)
 Frame = +2

Query: 230  MLCWGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGDHSVFLLEDGEVYTCGL 409
            MLCWG  S GQ G+    + IV EP+   F  ++ V++V CG  H+VF+L+DG VYTCG 
Sbjct: 1    MLCWGNASFGQLGLGGIDEEIVLEPRKSDFFINKKVRDVGCGLRHTVFVLDDGTVYTCGC 60

Query: 410  NTKGQLGHEREGNKPEQIGALADEHIVHVACGESHSLALSDRGQLFSWGAGSDGQLGLMT 589
            N  GQLGHE+   KPEQ+ AL  ++IV V+CGE+H+LAL+D+GQ+++WG  SDGQLGL+ 
Sbjct: 61   NDLGQLGHEKSRKKPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGLLG 120

Query: 590  TEESVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQAS 769
            +EE + VPR I+ L+   I+QV+CG +H LAL+   + F WG+N +GQLGLG +   QAS
Sbjct: 121  SEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGIDCKKQAS 180

Query: 770  PQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEEDRESPCHVKLLR 949
            PQ ++SL GIP  QVAAGGAHSF L+LSGA+FGWG N  GQLGL+DE DR  P  +K LR
Sbjct: 181  PQLIKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLR 240

Query: 950  AQKVVYISCGEEHTAVLTK 1006
             QK+VYI CGE+HTA LTK
Sbjct: 241  TQKIVYICCGEDHTAALTK 259



 Score = 30.4 bits (67), Expect(2) = 3e-85
 Identities = 13/17 (76%), Positives = 13/17 (76%)
 Frame = +1

Query: 1003 KSGGVFTFGAGSCGPLG 1053
            K GGVFTFGAG  G LG
Sbjct: 259  KEGGVFTFGAGGYGQLG 275



 Score =  127 bits (318), Expect = 2e-29
 Identities = 84/238 (35%), Positives = 123/238 (51%), Gaps = 4/238 (1%)
 Frame = +2

Query: 239 WGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGDHSVFLLEDGEVYTCGLNTK 418
           WG  S GQ G+  + +  +  P+    +SD  + +VACG  HS+ L +  EV+  G N  
Sbjct: 108 WGLDSDGQLGLLGS-EECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKY 166

Query: 419 GQLGHEREGNK---PEQIGALADEHIVHVACGESHSLALSDRGQLFSWGAGSDGQLGLMT 589
           GQLG   +  K   P+ I +L     + VA G +HS  L+  G +F WG    GQLGL  
Sbjct: 167 GQLGLGIDCKKQASPQLIKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGL-N 225

Query: 590 TEESVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQAS 769
            E    VP L++ L  Q I+ + CG  H  AL  +G  FT+G   +GQLG       + +
Sbjct: 226 DENDRYVPNLLKSLRTQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNST-SHEIN 284

Query: 770 PQRVRSLEGIPLAQVAAGGAHSFA-LSLSGAVFGWGMNNAGQLGLSDEEDRESPCHVK 940
           P++V  L G  + Q+A G  H+ A +  SG ++ +G+   GQLG     +R+SP  VK
Sbjct: 285 PRKVFELMGSIVTQIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRKSPFTVK 342



 Score =  102 bits (254), Expect = 6e-22
 Identities = 68/225 (30%), Positives = 110/225 (48%), Gaps = 17/225 (7%)
 Frame = +2

Query: 218 RTQTMLCWGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGDHSVFLLEDGEVY 397
           +   + CWG    GQ G+  + +   A PQ+   +      +VA GG HS  L   G ++
Sbjct: 154 KASEVFCWGQNKYGQLGLGIDCKK-QASPQLIKSLLGIPFMQVAAGGAHSFVLTLSGAIF 212

Query: 398 TCGLNTKGQLGHEREGNK--PEQIGALADEHIVHVACGESHSLALSDRGQLFSWGAGSDG 571
             G N  GQLG   E ++  P  + +L  + IV++ CGE H+ AL+  G +F++GAG  G
Sbjct: 213 GWGRNKFGQLGLNDENDRYVPNLLKSLRTQKIVYICCGEDHTAALTKEGGVFTFGAGGYG 272

Query: 572 QLGLMTTEESVAVPRLIQKLNQQTILQVSCGNWHCLA-LAADGQFFTWGKNSHGQLGLGK 748
           QLG  +T   +  PR + +L    + Q++CG  H  A + + G+ +++G   +GQLG G 
Sbjct: 273 QLGHNSTSHEIN-PRKVFELMGSIVTQIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGS 331

Query: 749 E-------------FPSQASPQRV-RSLEGIPLAQVAAGGAHSFA 841
                         FP     Q +  S E   + ++ +GG  SF+
Sbjct: 332 TSNRKSPFTVKGNWFPYNGHNQNIPNSEEYFCVKRIFSGGDQSFS 376


>ref|XP_859933.1| PREDICTED: similar to hect domain and RLD 4 isoform b isoform 7
            [Canis familiaris].
          Length = 1020

 Score =  304 bits (779), Expect(2) = 3e-85
 Identities = 147/259 (56%), Positives = 190/259 (73%)
 Frame = +2

Query: 230  MLCWGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGDHSVFLLEDGEVYTCGL 409
            MLCWG  S GQ G+    + IV EP+   F  ++ V++V CG  H+VF+L+DG VYTCG 
Sbjct: 1    MLCWGNASFGQLGLGGIDEEIVLEPRKSDFFINKKVRDVGCGLRHTVFVLDDGTVYTCGC 60

Query: 410  NTKGQLGHEREGNKPEQIGALADEHIVHVACGESHSLALSDRGQLFSWGAGSDGQLGLMT 589
            N  GQLGHE+   KPEQ+ AL  ++IV V+CGE+H+LAL+D+GQ+++WG  SDGQLGL+ 
Sbjct: 61   NDLGQLGHEKSRKKPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGLLG 120

Query: 590  TEESVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQAS 769
            +EE + VPR I+ L+   I+QV+CG +H LAL+   + F WG+N +GQLGLG +   QAS
Sbjct: 121  SEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGIDCKKQAS 180

Query: 770  PQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEEDRESPCHVKLLR 949
            PQ ++SL GIP  QVAAGGAHSF L+LSGA+FGWG N  GQLGL+DE DR  P  +K LR
Sbjct: 181  PQLIKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLR 240

Query: 950  AQKVVYISCGEEHTAVLTK 1006
             QK+VYI CGE+HTA LTK
Sbjct: 241  TQKIVYICCGEDHTAALTK 259



 Score = 30.4 bits (67), Expect(2) = 3e-85
 Identities = 13/17 (76%), Positives = 13/17 (76%)
 Frame = +1

Query: 1003 KSGGVFTFGAGSCGPLG 1053
            K GGVFTFGAG  G LG
Sbjct: 259  KEGGVFTFGAGGYGQLG 275



 Score =  127 bits (318), Expect = 2e-29
 Identities = 84/238 (35%), Positives = 123/238 (51%), Gaps = 4/238 (1%)
 Frame = +2

Query: 239 WGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGDHSVFLLEDGEVYTCGLNTK 418
           WG  S GQ G+  + +  +  P+    +SD  + +VACG  HS+ L +  EV+  G N  
Sbjct: 108 WGLDSDGQLGLLGS-EECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKY 166

Query: 419 GQLGHEREGNK---PEQIGALADEHIVHVACGESHSLALSDRGQLFSWGAGSDGQLGLMT 589
           GQLG   +  K   P+ I +L     + VA G +HS  L+  G +F WG    GQLGL  
Sbjct: 167 GQLGLGIDCKKQASPQLIKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGL-N 225

Query: 590 TEESVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQAS 769
            E    VP L++ L  Q I+ + CG  H  AL  +G  FT+G   +GQLG       + +
Sbjct: 226 DENDRYVPNLLKSLRTQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNST-SHEIN 284

Query: 770 PQRVRSLEGIPLAQVAAGGAHSFA-LSLSGAVFGWGMNNAGQLGLSDEEDRESPCHVK 940
           P++V  L G  + Q+A G  H+ A +  SG ++ +G+   GQLG     +R+SP  VK
Sbjct: 285 PRKVFELMGSIVTQIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRKSPFTVK 342



 Score =  102 bits (254), Expect = 6e-22
 Identities = 68/225 (30%), Positives = 110/225 (48%), Gaps = 17/225 (7%)
 Frame = +2

Query: 218 RTQTMLCWGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGDHSVFLLEDGEVY 397
           +   + CWG    GQ G+  + +   A PQ+   +      +VA GG HS  L   G ++
Sbjct: 154 KASEVFCWGQNKYGQLGLGIDCKK-QASPQLIKSLLGIPFMQVAAGGAHSFVLTLSGAIF 212

Query: 398 TCGLNTKGQLGHEREGNK--PEQIGALADEHIVHVACGESHSLALSDRGQLFSWGAGSDG 571
             G N  GQLG   E ++  P  + +L  + IV++ CGE H+ AL+  G +F++GAG  G
Sbjct: 213 GWGRNKFGQLGLNDENDRYVPNLLKSLRTQKIVYICCGEDHTAALTKEGGVFTFGAGGYG 272

Query: 572 QLGLMTTEESVAVPRLIQKLNQQTILQVSCGNWHCLA-LAADGQFFTWGKNSHGQLGLGK 748
           QLG  +T   +  PR + +L    + Q++CG  H  A + + G+ +++G   +GQLG G 
Sbjct: 273 QLGHNSTSHEIN-PRKVFELMGSIVTQIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGS 331

Query: 749 E-------------FPSQAS-PQRVRSLEGIPLAQVAAGGAHSFA 841
                         FP     P  + S E   + ++ +GG  SF+
Sbjct: 332 TSNRKSPFTVKGNWFPYNGQCPPDIDSEEYFCVKRIFSGGDQSFS 376


>ref|XP_859900.1| PREDICTED: similar to hect domain and RLD 4 isoform a isoform 6
            [Canis familiaris].
          Length = 979

 Score =  304 bits (779), Expect(2) = 3e-85
 Identities = 147/259 (56%), Positives = 190/259 (73%)
 Frame = +2

Query: 230  MLCWGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGDHSVFLLEDGEVYTCGL 409
            MLCWG  S GQ G+    + IV EP+   F  ++ V++V CG  H+VF+L+DG VYTCG 
Sbjct: 1    MLCWGNASFGQLGLGGIDEEIVLEPRKSDFFINKKVRDVGCGLRHTVFVLDDGTVYTCGC 60

Query: 410  NTKGQLGHEREGNKPEQIGALADEHIVHVACGESHSLALSDRGQLFSWGAGSDGQLGLMT 589
            N  GQLGHE+   KPEQ+ AL  ++IV V+CGE+H+LAL+D+GQ+++WG  SDGQLGL+ 
Sbjct: 61   NDLGQLGHEKSRKKPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGLLG 120

Query: 590  TEESVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQAS 769
            +EE + VPR I+ L+   I+QV+CG +H LAL+   + F WG+N +GQLGLG +   QAS
Sbjct: 121  SEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGIDCKKQAS 180

Query: 770  PQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEEDRESPCHVKLLR 949
            PQ ++SL GIP  QVAAGGAHSF L+LSGA+FGWG N  GQLGL+DE DR  P  +K LR
Sbjct: 181  PQLIKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLR 240

Query: 950  AQKVVYISCGEEHTAVLTK 1006
             QK+VYI CGE+HTA LTK
Sbjct: 241  TQKIVYICCGEDHTAALTK 259



 Score = 30.4 bits (67), Expect(2) = 3e-85
 Identities = 13/17 (76%), Positives = 13/17 (76%)
 Frame = +1

Query: 1003 KSGGVFTFGAGSCGPLG 1053
            K GGVFTFGAG  G LG
Sbjct: 259  KEGGVFTFGAGGYGQLG 275



 Score =  127 bits (318), Expect = 2e-29
 Identities = 84/238 (35%), Positives = 123/238 (51%), Gaps = 4/238 (1%)
 Frame = +2

Query: 239 WGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGDHSVFLLEDGEVYTCGLNTK 418
           WG  S GQ G+  + +  +  P+    +SD  + +VACG  HS+ L +  EV+  G N  
Sbjct: 108 WGLDSDGQLGLLGS-EECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKY 166

Query: 419 GQLGHEREGNK---PEQIGALADEHIVHVACGESHSLALSDRGQLFSWGAGSDGQLGLMT 589
           GQLG   +  K   P+ I +L     + VA G +HS  L+  G +F WG    GQLGL  
Sbjct: 167 GQLGLGIDCKKQASPQLIKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGL-N 225

Query: 590 TEESVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQAS 769
            E    VP L++ L  Q I+ + CG  H  AL  +G  FT+G   +GQLG       + +
Sbjct: 226 DENDRYVPNLLKSLRTQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNST-SHEIN 284

Query: 770 PQRVRSLEGIPLAQVAAGGAHSFA-LSLSGAVFGWGMNNAGQLGLSDEEDRESPCHVK 940
           P++V  L G  + Q+A G  H+ A +  SG ++ +G+   GQLG     +R+SP  VK
Sbjct: 285 PRKVFELMGSIVTQIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRKSPFTVK 342



 Score =  102 bits (254), Expect = 6e-22
 Identities = 68/225 (30%), Positives = 110/225 (48%), Gaps = 17/225 (7%)
 Frame = +2

Query: 218 RTQTMLCWGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGDHSVFLLEDGEVY 397
           +   + CWG    GQ G+  + +   A PQ+   +      +VA GG HS  L   G ++
Sbjct: 154 KASEVFCWGQNKYGQLGLGIDCKK-QASPQLIKSLLGIPFMQVAAGGAHSFVLTLSGAIF 212

Query: 398 TCGLNTKGQLGHEREGNK--PEQIGALADEHIVHVACGESHSLALSDRGQLFSWGAGSDG 571
             G N  GQLG   E ++  P  + +L  + IV++ CGE H+ AL+  G +F++GAG  G
Sbjct: 213 GWGRNKFGQLGLNDENDRYVPNLLKSLRTQKIVYICCGEDHTAALTKEGGVFTFGAGGYG 272

Query: 572 QLGLMTTEESVAVPRLIQKLNQQTILQVSCGNWHCLA-LAADGQFFTWGKNSHGQLGLGK 748
           QLG  +T   +  PR + +L    + Q++CG  H  A + + G+ +++G   +GQLG G 
Sbjct: 273 QLGHNSTSHEIN-PRKVFELMGSIVTQIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGS 331

Query: 749 E-------------FPSQAS-PQRVRSLEGIPLAQVAAGGAHSFA 841
                         FP     P  + S E   + ++ +GG  SF+
Sbjct: 332 TSNRKSPFTVKGNWFPYNGQCPPDIDSEEYFCVKRIFSGGDQSFS 376


>ref|XP_859760.1| PREDICTED: similar to hect domain and RLD 4 isoform b isoform 3
            [Canis familiaris].
          Length = 629

 Score =  304 bits (779), Expect(2) = 3e-85
 Identities = 147/259 (56%), Positives = 190/259 (73%)
 Frame = +2

Query: 230  MLCWGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGDHSVFLLEDGEVYTCGL 409
            MLCWG  S GQ G+    + IV EP+   F  ++ V++V CG  H+VF+L+DG VYTCG 
Sbjct: 1    MLCWGNASFGQLGLGGIDEEIVLEPRKSDFFINKKVRDVGCGLRHTVFVLDDGTVYTCGC 60

Query: 410  NTKGQLGHEREGNKPEQIGALADEHIVHVACGESHSLALSDRGQLFSWGAGSDGQLGLMT 589
            N  GQLGHE+   KPEQ+ AL  ++IV V+CGE+H+LAL+D+GQ+++WG  SDGQLGL+ 
Sbjct: 61   NDLGQLGHEKSRKKPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGLLG 120

Query: 590  TEESVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQAS 769
            +EE + VPR I+ L+   I+QV+CG +H LAL+   + F WG+N +GQLGLG +   QAS
Sbjct: 121  SEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGIDCKKQAS 180

Query: 770  PQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEEDRESPCHVKLLR 949
            PQ ++SL GIP  QVAAGGAHSF L+LSGA+FGWG N  GQLGL+DE DR  P  +K LR
Sbjct: 181  PQLIKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLR 240

Query: 950  AQKVVYISCGEEHTAVLTK 1006
             QK+VYI CGE+HTA LTK
Sbjct: 241  TQKIVYICCGEDHTAALTK 259



 Score = 30.4 bits (67), Expect(2) = 3e-85
 Identities = 13/17 (76%), Positives = 13/17 (76%)
 Frame = +1

Query: 1003 KSGGVFTFGAGSCGPLG 1053
            K GGVFTFGAG  G LG
Sbjct: 259  KEGGVFTFGAGGYGQLG 275



 Score =  127 bits (318), Expect = 2e-29
 Identities = 84/238 (35%), Positives = 123/238 (51%), Gaps = 4/238 (1%)
 Frame = +2

Query: 239 WGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGDHSVFLLEDGEVYTCGLNTK 418
           WG  S GQ G+  + +  +  P+    +SD  + +VACG  HS+ L +  EV+  G N  
Sbjct: 108 WGLDSDGQLGLLGS-EECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKY 166

Query: 419 GQLGHEREGNK---PEQIGALADEHIVHVACGESHSLALSDRGQLFSWGAGSDGQLGLMT 589
           GQLG   +  K   P+ I +L     + VA G +HS  L+  G +F WG    GQLGL  
Sbjct: 167 GQLGLGIDCKKQASPQLIKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGL-N 225

Query: 590 TEESVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQAS 769
            E    VP L++ L  Q I+ + CG  H  AL  +G  FT+G   +GQLG       + +
Sbjct: 226 DENDRYVPNLLKSLRTQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNST-SHEIN 284

Query: 770 PQRVRSLEGIPLAQVAAGGAHSFA-LSLSGAVFGWGMNNAGQLGLSDEEDRESPCHVK 940
           P++V  L G  + Q+A G  H+ A +  SG ++ +G+   GQLG     +R+SP  VK
Sbjct: 285 PRKVFELMGSIVTQIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRKSPFTVK 342



 Score =  102 bits (254), Expect = 6e-22
 Identities = 68/225 (30%), Positives = 110/225 (48%), Gaps = 17/225 (7%)
 Frame = +2

Query: 218 RTQTMLCWGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGDHSVFLLEDGEVY 397
           +   + CWG    GQ G+  + +   A PQ+   +      +VA GG HS  L   G ++
Sbjct: 154 KASEVFCWGQNKYGQLGLGIDCKK-QASPQLIKSLLGIPFMQVAAGGAHSFVLTLSGAIF 212

Query: 398 TCGLNTKGQLGHEREGNK--PEQIGALADEHIVHVACGESHSLALSDRGQLFSWGAGSDG 571
             G N  GQLG   E ++  P  + +L  + IV++ CGE H+ AL+  G +F++GAG  G
Sbjct: 213 GWGRNKFGQLGLNDENDRYVPNLLKSLRTQKIVYICCGEDHTAALTKEGGVFTFGAGGYG 272

Query: 572 QLGLMTTEESVAVPRLIQKLNQQTILQVSCGNWHCLA-LAADGQFFTWGKNSHGQLGLGK 748
           QLG  +T   +  PR + +L    + Q++CG  H  A + + G+ +++G   +GQLG G 
Sbjct: 273 QLGHNSTSHEIN-PRKVFELMGSIVTQIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGS 331

Query: 749 E-------------FPSQAS-PQRVRSLEGIPLAQVAAGGAHSFA 841
                         FP     P  + S E   + ++ +GG  SF+
Sbjct: 332 TSNRKSPFTVKGNWFPYNGQCPPDIDSEEYFCVKRIFSGGDQSFS 376


>ref|XP_859830.1| PREDICTED: similar to hect domain and RLD 4 isoform b isoform 4
            [Canis familiaris].
          Length = 488

 Score =  304 bits (779), Expect(2) = 3e-85
 Identities = 147/259 (56%), Positives = 190/259 (73%)
 Frame = +2

Query: 230  MLCWGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGDHSVFLLEDGEVYTCGL 409
            MLCWG  S GQ G+    + IV EP+   F  ++ V++V CG  H+VF+L+DG VYTCG 
Sbjct: 1    MLCWGNASFGQLGLGGIDEEIVLEPRKSDFFINKKVRDVGCGLRHTVFVLDDGTVYTCGC 60

Query: 410  NTKGQLGHEREGNKPEQIGALADEHIVHVACGESHSLALSDRGQLFSWGAGSDGQLGLMT 589
            N  GQLGHE+   KPEQ+ AL  ++IV V+CGE+H+LAL+D+GQ+++WG  SDGQLGL+ 
Sbjct: 61   NDLGQLGHEKSRKKPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGLLG 120

Query: 590  TEESVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQAS 769
            +EE + VPR I+ L+   I+QV+CG +H LAL+   + F WG+N +GQLGLG +   QAS
Sbjct: 121  SEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGIDCKKQAS 180

Query: 770  PQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEEDRESPCHVKLLR 949
            PQ ++SL GIP  QVAAGGAHSF L+LSGA+FGWG N  GQLGL+DE DR  P  +K LR
Sbjct: 181  PQLIKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLR 240

Query: 950  AQKVVYISCGEEHTAVLTK 1006
             QK+VYI CGE+HTA LTK
Sbjct: 241  TQKIVYICCGEDHTAALTK 259



 Score = 30.4 bits (67), Expect(2) = 3e-85
 Identities = 13/17 (76%), Positives = 13/17 (76%)
 Frame = +1

Query: 1003 KSGGVFTFGAGSCGPLG 1053
            K GGVFTFGAG  G LG
Sbjct: 259  KEGGVFTFGAGGYGQLG 275



 Score =  127 bits (318), Expect = 2e-29
 Identities = 84/238 (35%), Positives = 123/238 (51%), Gaps = 4/238 (1%)
 Frame = +2

Query: 239 WGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGDHSVFLLEDGEVYTCGLNTK 418
           WG  S GQ G+  + +  +  P+    +SD  + +VACG  HS+ L +  EV+  G N  
Sbjct: 108 WGLDSDGQLGLLGS-EECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKY 166

Query: 419 GQLGHEREGNK---PEQIGALADEHIVHVACGESHSLALSDRGQLFSWGAGSDGQLGLMT 589
           GQLG   +  K   P+ I +L     + VA G +HS  L+  G +F WG    GQLGL  
Sbjct: 167 GQLGLGIDCKKQASPQLIKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGL-N 225

Query: 590 TEESVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQAS 769
            E    VP L++ L  Q I+ + CG  H  AL  +G  FT+G   +GQLG       + +
Sbjct: 226 DENDRYVPNLLKSLRTQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNST-SHEIN 284

Query: 770 PQRVRSLEGIPLAQVAAGGAHSFA-LSLSGAVFGWGMNNAGQLGLSDEEDRESPCHVK 940
           P++V  L G  + Q+A G  H+ A +  SG ++ +G+   GQLG     +R+SP  VK
Sbjct: 285 PRKVFELMGSIVTQIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRKSPFTVK 342



 Score =  102 bits (254), Expect = 6e-22
 Identities = 68/225 (30%), Positives = 110/225 (48%), Gaps = 17/225 (7%)
 Frame = +2

Query: 218 RTQTMLCWGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGDHSVFLLEDGEVY 397
           +   + CWG    GQ G+  + +   A PQ+   +      +VA GG HS  L   G ++
Sbjct: 154 KASEVFCWGQNKYGQLGLGIDCKK-QASPQLIKSLLGIPFMQVAAGGAHSFVLTLSGAIF 212

Query: 398 TCGLNTKGQLGHEREGNK--PEQIGALADEHIVHVACGESHSLALSDRGQLFSWGAGSDG 571
             G N  GQLG   E ++  P  + +L  + IV++ CGE H+ AL+  G +F++GAG  G
Sbjct: 213 GWGRNKFGQLGLNDENDRYVPNLLKSLRTQKIVYICCGEDHTAALTKEGGVFTFGAGGYG 272

Query: 572 QLGLMTTEESVAVPRLIQKLNQQTILQVSCGNWHCLA-LAADGQFFTWGKNSHGQLGLGK 748
           QLG  +T   +  PR + +L    + Q++CG  H  A + + G+ +++G   +GQLG G 
Sbjct: 273 QLGHNSTSHEIN-PRKVFELMGSIVTQIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGS 331

Query: 749 E-------------FPSQAS-PQRVRSLEGIPLAQVAAGGAHSFA 841
                         FP     P  + S E   + ++ +GG  SF+
Sbjct: 332 TSNRKSPFTVKGNWFPYNGQCPPDIDSEEYFCVKRIFSGGDQSFS 376


  Database: RefSeq49_CP.fasta
    Posted date:  Oct 17, 2011  1:42 PM
  Number of letters in database: 18,874,504
  Number of sequences in database:  33,336
  
Lambda     K      H
   0.318    0.134    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 33336
Number of Hits to DB: 51,583,697
Number of extensions: 1651428
Number of successful extensions: 9126
Number of sequences better than 1.0e-05: 30
Number of HSP's gapped: 8606
Number of HSP's successfully gapped: 153
Length of query: 351
Length of database: 18,874,504
Length adjustment: 104
Effective length of query: 247
Effective length of database: 15,407,560
Effective search space: 3805667320
Effective search space used: 3805667320
Neighboring words threshold: 12
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 35 (18.1 bits)

BLASTX 2.2.24 [Aug-08-2010]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= 20110601C-003003
         (1053 letters)

Database: RefSeq49_HP.fasta 
           32,964 sequences; 18,297,164 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

Alignment   gi|NP_055421.1| probable E3 ubiquitin-protein ligase HERC3 [Hom...   528   e-154
Alignment   gi|NP_071362.1| probable E3 ubiquitin-protein ligase HERC4 isof...   302   1e-84
Alignment   gi|NP_056416.2| probable E3 ubiquitin-protein ligase HERC4 isof...   302   1e-84
Alignment   gi|NP_001158608.1| probable E3 ubiquitin-protein ligase HERC6 i...   249   3e-66
Alignment   gi|NP_060382.3| probable E3 ubiquitin-protein ligase HERC6 isof...   249   3e-66
Alignment   gi|NP_004658.3| E3 ubiquitin-protein ligase HERC2 [Homo sapiens].    164   1e-40
Alignment   gi|NP_057407.2| E3 ISG15--protein ligase HERC5 [Homo sapiens].       146   7e-36
Alignment   gi|NP_001259.1| RCC1 and BTB domain-containing protein 2 [Homo ...   145   8e-35
Alignment   gi|NP_060661.3| RCC1 and BTB domain-containing protein 1 [Homo ...   137   1e-32
Alignment   gi|NP_000319.1| X-linked retinitis pigmentosa GTPase regulator ...   131   9e-31

>ref|NP_055421.1| probable E3 ubiquitin-protein ligase HERC3 [Homo sapiens].
          Length = 1050

 Score =  528 bits (1359), Expect(2) = e-154
 Identities = 253/259 (97%), Positives = 258/259 (99%)
 Frame = +2

Query: 230  MLCWGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGDHSVFLLEDGEVYTCGL 409
            MLCWGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGG+HSVFLLEDGEVYTCGL
Sbjct: 1    MLCWGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGNHSVFLLEDGEVYTCGL 60

Query: 410  NTKGQLGHEREGNKPEQIGALADEHIVHVACGESHSLALSDRGQLFSWGAGSDGQLGLMT 589
            NTKGQLGHEREGNKPEQIGALAD+HI+HVACGESHSLALSDRGQLFSWGAGSDGQLGLMT
Sbjct: 61   NTKGQLGHEREGNKPEQIGALADQHIIHVACGESHSLALSDRGQLFSWGAGSDGQLGLMT 120

Query: 590  TEESVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQAS 769
            TE+SVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQAS
Sbjct: 121  TEDSVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQAS 180

Query: 770  PQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEEDRESPCHVKLLR 949
            PQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDE+DRESPCHVKLLR
Sbjct: 181  PQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEKDRESPCHVKLLR 240

Query: 950  AQKVVYISCGEEHTAVLTK 1006
             QKVVYISCGEEHTAVLTK
Sbjct: 241  TQKVVYISCGEEHTAVLTK 259



 Score = 37.7 bits (86), Expect(2) = e-154
 Identities = 16/17 (94%), Positives = 16/17 (94%)
 Frame = +1

Query: 1003 KSGGVFTFGAGSCGPLG 1053
            KSGGVFTFGAGSCG LG
Sbjct: 259  KSGGVFTFGAGSCGQLG 275



 Score =  130 bits (326), Expect = 3e-30
 Identities = 82/241 (34%), Positives = 127/241 (52%), Gaps = 4/241 (1%)
 Frame = +2

Query: 230 MLCWGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGDHSVFLLEDGEVYTCGL 409
           +  WG  S GQ G+ T  +  VA P++   ++ +++ +V+CG  H + L  DG+ +T G 
Sbjct: 105 LFSWGAGSDGQLGLMTT-EDSVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGK 163

Query: 410 NTKGQLGHERE---GNKPEQIGALADEHIVHVACGESHSLALSDRGQLFSWGAGSDGQLG 580
           N+ GQLG  +E      P+++ +L    +  VA G +HS ALS  G +F WG  + GQLG
Sbjct: 164 NSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLG 223

Query: 581 LMTTEESVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPS 760
           L + E+    P  ++ L  Q ++ +SCG  H   L   G  FT+G  S GQLG       
Sbjct: 224 L-SDEKDRESPCHVKLLRTQKVVYISCGEEHTAVLTKSGGVFTFGAGSCGQLG-HDSMND 281

Query: 761 QASPQRVRSLEGIPLAQVAAGGAHSFA-LSLSGAVFGWGMNNAGQLGLSDEEDRESPCHV 937
           + +P+RV  L G  + Q+A G  H+ A +  SG ++ +G    GQLG     + + P  V
Sbjct: 282 EVNPRRVLELMGSEVTQIACGRQHTLAFVPSSGLIYAFGCGARGQLGTGHTCNVKCPSPV 341

Query: 938 K 940
           K
Sbjct: 342 K 342


>ref|NP_071362.1| probable E3 ubiquitin-protein ligase HERC4 isoform a [Homo sapiens].
          Length = 1057

 Score =  302 bits (774), Expect(2) = 1e-84
 Identities = 146/259 (56%), Positives = 190/259 (73%)
 Frame = +2

Query: 230  MLCWGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGDHSVFLLEDGEVYTCGL 409
            MLCWG  S GQ G+    + IV EP+   F  ++ V++V CG  H+VF+L+DG VYTCG 
Sbjct: 1    MLCWGNASFGQLGLGGIDEEIVLEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGC 60

Query: 410  NTKGQLGHEREGNKPEQIGALADEHIVHVACGESHSLALSDRGQLFSWGAGSDGQLGLMT 589
            N  GQLGHE+   KPEQ+ AL  ++IV V+CGE+H+LAL+D+GQ+++WG  SDGQLGL+ 
Sbjct: 61   NDLGQLGHEKSRKKPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGLVG 120

Query: 590  TEESVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQAS 769
            +EE + VPR I+ L+   I+QV+CG +H LAL+   + F WG+N +GQLGLG +   Q S
Sbjct: 121  SEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKKQTS 180

Query: 770  PQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEEDRESPCHVKLLR 949
            PQ ++SL GIP  QVAAGGAHSF L+LSGA+FGWG N  GQLGL+DE DR  P  +K LR
Sbjct: 181  PQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLR 240

Query: 950  AQKVVYISCGEEHTAVLTK 1006
            +QK+VYI CGE+HTA LTK
Sbjct: 241  SQKIVYICCGEDHTAALTK 259



 Score = 30.4 bits (67), Expect(2) = 1e-84
 Identities = 13/17 (76%), Positives = 13/17 (76%)
 Frame = +1

Query: 1003 KSGGVFTFGAGSCGPLG 1053
            K GGVFTFGAG  G LG
Sbjct: 259  KEGGVFTFGAGGYGQLG 275



 Score =  126 bits (317), Expect = 3e-29
 Identities = 82/238 (34%), Positives = 122/238 (51%), Gaps = 4/238 (1%)
 Frame = +2

Query: 239 WGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGDHSVFLLEDGEVYTCGLNTK 418
           WG  S GQ G+    +  +  P+    +SD  + +VACG  HS+ L +  EV+  G N  
Sbjct: 108 WGLDSDGQLGL-VGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKY 166

Query: 419 GQLGHEREGNK---PEQIGALADEHIVHVACGESHSLALSDRGQLFSWGAGSDGQLGLMT 589
           GQLG   +  K   P+ + +L     + VA G +HS  L+  G +F WG    GQLGL  
Sbjct: 167 GQLGLGTDCKKQTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGL-N 225

Query: 590 TEESVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQAS 769
            E    VP L++ L  Q I+ + CG  H  AL  +G  FT+G   +GQLG       + +
Sbjct: 226 DENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNST-SHEIN 284

Query: 770 PQRVRSLEGIPLAQVAAGGAHSFA-LSLSGAVFGWGMNNAGQLGLSDEEDRESPCHVK 940
           P++V  L G  + ++A G  H+ A +  SG ++ +G+   GQLG     +R+SP  VK
Sbjct: 285 PRKVFELMGSIVTEIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRKSPFTVK 342



 Score =  101 bits (251), Expect = 1e-21
 Identities = 58/179 (32%), Positives = 96/179 (53%), Gaps = 3/179 (1%)
 Frame = +2

Query: 218 RTQTMLCWGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGDHSVFLLEDGEVY 397
           +   + CWG    GQ G+ T+ +   + PQ+   +      +VA GG HS  L   G ++
Sbjct: 154 KASEVFCWGQNKYGQLGLGTDCKKQTS-PQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIF 212

Query: 398 TCGLNTKGQLGHEREGNK--PEQIGALADEHIVHVACGESHSLALSDRGQLFSWGAGSDG 571
             G N  GQLG   E ++  P  + +L  + IV++ CGE H+ AL+  G +F++GAG  G
Sbjct: 213 GWGRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYG 272

Query: 572 QLGLMTTEESVAVPRLIQKLNQQTILQVSCGNWHCLA-LAADGQFFTWGKNSHGQLGLG 745
           QLG  +T   +  PR + +L    + +++CG  H  A + + G+ +++G   +GQLG G
Sbjct: 273 QLGHNSTSHEIN-PRKVFELMGSIVTEIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTG 330


>ref|NP_056416.2| probable E3 ubiquitin-protein ligase HERC4 isoform b [Homo sapiens].
          Length = 1049

 Score =  302 bits (774), Expect(2) = 1e-84
 Identities = 146/259 (56%), Positives = 190/259 (73%)
 Frame = +2

Query: 230  MLCWGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGDHSVFLLEDGEVYTCGL 409
            MLCWG  S GQ G+    + IV EP+   F  ++ V++V CG  H+VF+L+DG VYTCG 
Sbjct: 1    MLCWGNASFGQLGLGGIDEEIVLEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGC 60

Query: 410  NTKGQLGHEREGNKPEQIGALADEHIVHVACGESHSLALSDRGQLFSWGAGSDGQLGLMT 589
            N  GQLGHE+   KPEQ+ AL  ++IV V+CGE+H+LAL+D+GQ+++WG  SDGQLGL+ 
Sbjct: 61   NDLGQLGHEKSRKKPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGLVG 120

Query: 590  TEESVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQAS 769
            +EE + VPR I+ L+   I+QV+CG +H LAL+   + F WG+N +GQLGLG +   Q S
Sbjct: 121  SEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKKQTS 180

Query: 770  PQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEEDRESPCHVKLLR 949
            PQ ++SL GIP  QVAAGGAHSF L+LSGA+FGWG N  GQLGL+DE DR  P  +K LR
Sbjct: 181  PQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLR 240

Query: 950  AQKVVYISCGEEHTAVLTK 1006
            +QK+VYI CGE+HTA LTK
Sbjct: 241  SQKIVYICCGEDHTAALTK 259



 Score = 30.4 bits (67), Expect(2) = 1e-84
 Identities = 13/17 (76%), Positives = 13/17 (76%)
 Frame = +1

Query: 1003 KSGGVFTFGAGSCGPLG 1053
            K GGVFTFGAG  G LG
Sbjct: 259  KEGGVFTFGAGGYGQLG 275



 Score =  126 bits (317), Expect = 3e-29
 Identities = 82/238 (34%), Positives = 122/238 (51%), Gaps = 4/238 (1%)
 Frame = +2

Query: 239 WGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGDHSVFLLEDGEVYTCGLNTK 418
           WG  S GQ G+    +  +  P+    +SD  + +VACG  HS+ L +  EV+  G N  
Sbjct: 108 WGLDSDGQLGL-VGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKY 166

Query: 419 GQLGHEREGNK---PEQIGALADEHIVHVACGESHSLALSDRGQLFSWGAGSDGQLGLMT 589
           GQLG   +  K   P+ + +L     + VA G +HS  L+  G +F WG    GQLGL  
Sbjct: 167 GQLGLGTDCKKQTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGL-N 225

Query: 590 TEESVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQAS 769
            E    VP L++ L  Q I+ + CG  H  AL  +G  FT+G   +GQLG       + +
Sbjct: 226 DENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNST-SHEIN 284

Query: 770 PQRVRSLEGIPLAQVAAGGAHSFA-LSLSGAVFGWGMNNAGQLGLSDEEDRESPCHVK 940
           P++V  L G  + ++A G  H+ A +  SG ++ +G+   GQLG     +R+SP  VK
Sbjct: 285 PRKVFELMGSIVTEIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRKSPFTVK 342



 Score =  101 bits (251), Expect = 1e-21
 Identities = 58/179 (32%), Positives = 96/179 (53%), Gaps = 3/179 (1%)
 Frame = +2

Query: 218 RTQTMLCWGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGDHSVFLLEDGEVY 397
           +   + CWG    GQ G+ T+ +   + PQ+   +      +VA GG HS  L   G ++
Sbjct: 154 KASEVFCWGQNKYGQLGLGTDCKKQTS-PQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIF 212

Query: 398 TCGLNTKGQLGHEREGNK--PEQIGALADEHIVHVACGESHSLALSDRGQLFSWGAGSDG 571
             G N  GQLG   E ++  P  + +L  + IV++ CGE H+ AL+  G +F++GAG  G
Sbjct: 213 GWGRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYG 272

Query: 572 QLGLMTTEESVAVPRLIQKLNQQTILQVSCGNWHCLA-LAADGQFFTWGKNSHGQLGLG 745
           QLG  +T   +  PR + +L    + +++CG  H  A + + G+ +++G   +GQLG G
Sbjct: 273 QLGHNSTSHEIN-PRKVFELMGSIVTEIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTG 330


>ref|NP_001158608.1| probable E3 ubiquitin-protein ligase HERC6 isoform 2 [Homo sapiens].
          Length = 986

 Score =  249 bits (636), Expect = 3e-66
 Identities = 131/227 (57%), Positives = 159/227 (70%), Gaps = 5/227 (2%)
 Frame = +2

Query: 341  EVACGGDHSVFLLEDGEVYTCGLNTKGQLGHE--REGNKPEQIGALADEHIVHVACGESH 514
            + A G  HS+ LL +  V +CG N++GQLG    + G  PE I AL    +  V+CG+ H
Sbjct: 27   QAASGERHSLLLLTNHRVLSCGDNSRGQLGRRGAQRGELPEPIQALETLIVDLVSCGKEH 86

Query: 515  SLALSDRGQLFSWGAGSDGQLGLMTTEESVAVPRLIQKLNQQTILQVSCGNWHCLALAAD 694
            SLA+  +G++F+WGAGS+GQLG+   +E    P+ I  LN   I+QVSCG++H LAL+ D
Sbjct: 87   SLAVCHKGRVFAWGAGSEGQLGIGEFKEISFTPKKIMTLNDIKIIQVSCGHYHSLALSKD 146

Query: 695  GQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWG 874
             Q F+WGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSL G  FGWG
Sbjct: 147  SQVFSWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLCGTSFGWG 206

Query: 875  MNNAGQLGLSDEE---DRESPCHVKLLRAQKVVYISCGEEHTAVLTK 1006
             N+AGQL LS          P  V  L+   VVYISCG+ HTAVLT+
Sbjct: 207  SNSAGQLALSGRNVPVQSNKPLSVGALKNLGVVYISCGDAHTAVLTQ 253



 Score = 82.4 bits (202), Expect = 6e-16
 Identities = 53/165 (32%), Positives = 87/165 (52%), Gaps = 6/165 (3%)
 Frame = +2

Query: 239 WGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGDHSVFLLEDGEVYTCGLNTK 418
           WG  S GQ G+        A PQ    +    + +VA GG HS  L   G  +  G N+ 
Sbjct: 152 WGKNSHGQLGLGKEFPS-QASPQRVRSLEGIPLAQVAAGGAHSFALSLCGTSFGWGSNSA 210

Query: 419 GQLGHER-----EGNKPEQIGALADEHIVHVACGESHSLALSDRGQLFSWGAGSDGQLGL 583
           GQL         + NKP  +GAL +  +V+++CG++H+  L+  G++F++G    GQLG 
Sbjct: 211 GQLALSGRNVPVQSNKPLSVGALKNLGVVYISCGDAHTAVLTQDGKVFTFGDNRSGQLGY 270

Query: 584 MTTEESVAVPRLIQKLNQQTILQVSCGNWHCLA-LAADGQFFTWG 715
             T E    P+L+++++   + Q+ CG++H LA +   GQ  ++G
Sbjct: 271 SPTPEKRG-PQLVERID-GLVSQIDCGSYHTLAYVHTTGQVVSFG 313


>ref|NP_060382.3| probable E3 ubiquitin-protein ligase HERC6 isoform 1 [Homo sapiens].
          Length = 1022

 Score =  249 bits (636), Expect = 3e-66
 Identities = 131/227 (57%), Positives = 159/227 (70%), Gaps = 5/227 (2%)
 Frame = +2

Query: 341  EVACGGDHSVFLLEDGEVYTCGLNTKGQLGHE--REGNKPEQIGALADEHIVHVACGESH 514
            + A G  HS+ LL +  V +CG N++GQLG    + G  PE I AL    +  V+CG+ H
Sbjct: 27   QAASGERHSLLLLTNHRVLSCGDNSRGQLGRRGAQRGELPEPIQALETLIVDLVSCGKEH 86

Query: 515  SLALSDRGQLFSWGAGSDGQLGLMTTEESVAVPRLIQKLNQQTILQVSCGNWHCLALAAD 694
            SLA+  +G++F+WGAGS+GQLG+   +E    P+ I  LN   I+QVSCG++H LAL+ D
Sbjct: 87   SLAVCHKGRVFAWGAGSEGQLGIGEFKEISFTPKKIMTLNDIKIIQVSCGHYHSLALSKD 146

Query: 695  GQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWG 874
             Q F+WGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSL G  FGWG
Sbjct: 147  SQVFSWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLCGTSFGWG 206

Query: 875  MNNAGQLGLSDEE---DRESPCHVKLLRAQKVVYISCGEEHTAVLTK 1006
             N+AGQL LS          P  V  L+   VVYISCG+ HTAVLT+
Sbjct: 207  SNSAGQLALSGRNVPVQSNKPLSVGALKNLGVVYISCGDAHTAVLTQ 253



 Score = 82.4 bits (202), Expect = 6e-16
 Identities = 53/165 (32%), Positives = 87/165 (52%), Gaps = 6/165 (3%)
 Frame = +2

Query: 239 WGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGDHSVFLLEDGEVYTCGLNTK 418
           WG  S GQ G+        A PQ    +    + +VA GG HS  L   G  +  G N+ 
Sbjct: 152 WGKNSHGQLGLGKEFPS-QASPQRVRSLEGIPLAQVAAGGAHSFALSLCGTSFGWGSNSA 210

Query: 419 GQLGHER-----EGNKPEQIGALADEHIVHVACGESHSLALSDRGQLFSWGAGSDGQLGL 583
           GQL         + NKP  +GAL +  +V+++CG++H+  L+  G++F++G    GQLG 
Sbjct: 211 GQLALSGRNVPVQSNKPLSVGALKNLGVVYISCGDAHTAVLTQDGKVFTFGDNRSGQLGY 270

Query: 584 MTTEESVAVPRLIQKLNQQTILQVSCGNWHCLA-LAADGQFFTWG 715
             T E    P+L+++++   + Q+ CG++H LA +   GQ  ++G
Sbjct: 271 SPTPEKRG-PQLVERID-GLVSQIDCGSYHTLAYVHTTGQVVSFG 313


>ref|NP_004658.3| E3 ubiquitin-protein ligase HERC2 [Homo sapiens].
          Length = 4834

 Score =  164 bits (415), Expect = 1e-40
 Identities = 94/271 (34%), Positives = 140/271 (51%), Gaps = 4/271 (1%)
 Frame = +2

Query: 239  WGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGDHSVFLLEDGEVYTCGLNTK 418
            WG    G+ G  + +     +P++   +  + ++++ACG  HS  L   GE+YT GL   
Sbjct: 3071 WGEGDDGKLGHFSRMN--CDKPRLIEALKTKRIRDIACGSSHSAALTSSGELYTWGLGEY 3128

Query: 419  GQLGHEREGN--KPEQIGALADEHIVHVACG--ESHSLALSDRGQLFSWGAGSDGQLGLM 586
            G+LGH       KP+ +  L    ++ VACG  ++ +LAL+D G +FSWG G  G+LG  
Sbjct: 3129 GRLGHGDNTTQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFSWGDGDFGKLG-R 3187

Query: 587  TTEESVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQA 766
               E   +P+ I++LN Q + Q+ CG    LAL   G  +TWGK  + +LG G +   + 
Sbjct: 3188 GGSEGCNIPQNIERLNGQGVCQIECGAQFSLALTKSGVVWTWGKGDYFRLGHGSDVHVR- 3246

Query: 767  SPQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEEDRESPCHVKLL 946
             PQ V  L G  +  VA G  H  A++ SG V+ WG N+ GQ G         P  V+ L
Sbjct: 3247 KPQVVEGLRGKKIVHVAVGALHCLAVTDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQGL 3306

Query: 947  RAQKVVYISCGEEHTAVLTKVEVCLPLVLVP 1039
              QK+  ++CG  H+   T V+V  P V  P
Sbjct: 3307 EGQKITRVACGSSHSVAWTTVDVATPSVHEP 3337



 Score =  134 bits (336), Expect = 2e-31
 Identities = 93/262 (35%), Positives = 136/262 (51%), Gaps = 9/262 (3%)
 Frame = +2

Query: 248  WSLGQPGISTNLQGI-VAEPQVCGFISDRSVKEVACGGDHSVFLLE-DGEVYTCGLNTKG 421
            W L        L+G  +  P     +S  +V +VA GG  S+F +  +G+VY CG  T G
Sbjct: 2964 WGLNDKDQLGGLKGSKIKVPSFSETLSALNVVQVA-GGSKSLFAVTVEGKVYACGEATNG 3022

Query: 422  QLGHEREGNK---PEQIGALADEHIVHVA--CGESHSLALSDRGQLFSWGAGSDGQLGLM 586
            +LG          P QI AL+   +  VA   G  H+ AL+  G++FSWG G DG+LG  
Sbjct: 3023 RLGLGISSGTVPIPRQITALSSYVVKKVAVHSGGRHATALTVDGKVFSWGEGDDGKLGHF 3082

Query: 587  TTEESVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQA 766
             +  +   PRLI+ L  + I  ++CG+ H  AL + G+ +TWG   +G+LG G +  +Q 
Sbjct: 3083 -SRMNCDKPRLIEALKTKRIRDIACGSSHSAALTSSGELYTWGLGEYGRLGHG-DNTTQL 3140

Query: 767  SPQRVRSLEGIPLAQVAAGG--AHSFALSLSGAVFGWGMNNAGQLGLSDEEDRESPCHVK 940
             P+ V+ L G  + QVA G   A + AL+  G VF WG  + G+LG    E    P +++
Sbjct: 3141 KPKMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFSWGDGDFGKLGRGGSEGCNIPQNIE 3200

Query: 941  LLRAQKVVYISCGEEHTAVLTK 1006
             L  Q V  I CG + +  LTK
Sbjct: 3201 RLNGQGVCQIECGAQFSLALTK 3222



 Score =  132 bits (331), Expect = 7e-31
 Identities = 77/245 (31%), Positives = 135/245 (55%), Gaps = 10/245 (4%)
 Frame = +2

Query: 302  PQVCGFISDRSVKEVACGGD--HSVFLLEDGEVYTCGLNTKGQLGHEREG--NKPEQIGA 469
            PQ+   ++ R++ ++A   D  H + L   GEVY+ G    G+LGH       +P+ I A
Sbjct: 484  PQLVQGLASRNIVKIAAHSDGHHYLALAATGEVYSWGCGDGGRLGHGDTVPLEEPKVISA 543

Query: 470  L----ADEHIVHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTEESVAVPRLIQKLNQ 637
                 A +H+VH+ACG ++S A++  G+L++WG G+ G+LG  ++E+  A+P L+  L  
Sbjct: 544  FSGKQAGKHVVHIACGSTYSAAITAEGELYTWGRGNYGRLGHGSSEDE-AIPMLVAGLKG 602

Query: 638  QTILQVSCGNW--HCLALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQ 811
              ++ V+CG+     LA+  +GQ ++WG   +G+LG G       +P+ +  L+ + + +
Sbjct: 603  LKVIDVACGSGDAQTLAVTENGQVWSWGDGDYGKLGRGGS-DGCKTPKLIEKLQDLDVVK 661

Query: 812  VAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEEDRESPCHVKLLRAQKVVYISCGEEHT 991
            V  G   S AL+  G V+ WG  +  +LG   EE    P  ++ L+ +KV+ ++ G  H 
Sbjct: 662  VRCGSQFSIALTKDGQVYSWGKGDNQRLGHGTEEHVRYPKLLEGLQGKKVIDVAAGSTHC 721

Query: 992  AVLTK 1006
              LT+
Sbjct: 722  LALTE 726



 Score =  130 bits (326), Expect = 3e-30
 Identities = 77/234 (32%), Positives = 120/234 (51%), Gaps = 4/234 (1%)
 Frame = +2

Query: 302  PQVCGFISDRSVKEVACGGDHSVFLLEDGEVYTCGLNTKGQLGHEREGN--KPEQIGALA 475
            P+V   +    V +VA GG HS  +   G++YT G    G+LGH    +  KP+ + AL 
Sbjct: 4082 PRVIESLRGIEVVDVAAGGAHSACVTAAGDLYTWGKGRYGRLGHSDSEDQLKPKLVEALQ 4141

Query: 476  DEHIVHVACG--ESHSLALSDRGQLFSWGAGSDGQLGLMTTEESVAVPRLIQKLNQQTIL 649
               +V +ACG  ++ +L L+D   ++SWG G  G+LG     +   VP  I  L    ++
Sbjct: 4142 GHRVVDIACGSGDAQTLCLTDDDTVWSWGDGDYGKLG-RGGSDGCKVPMKIDSLTGLGVV 4200

Query: 650  QVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGA 829
            +V CG+   +AL   G  +TWGK  + +LG G +      P++V+ L+G  +  +A G  
Sbjct: 4201 KVECGSQFSVALTKSGAVYTWGKGDYHRLGHGSD-DHVRRPRQVQGLQGKKVIAIATGSL 4259

Query: 830  HSFALSLSGAVFGWGMNNAGQLGLSDEEDRESPCHVKLLRAQKVVYISCGEEHT 991
            H    +  G V+ WG N+ GQLG       + P  V  L+ +KV  ++CG  HT
Sbjct: 4260 HCVCCTEDGEVYTWGDNDEGQLGDGTTNAIQRPRLVAALQGKKVNRVACGSAHT 4313



 Score =  128 bits (321), Expect = 1e-29
 Identities = 79/203 (38%), Positives = 118/203 (58%), Gaps = 5/203 (2%)
 Frame = +2

Query: 386  GEVYTCGLNTKGQLGHEREGNK---PEQIGALADEHIVHVACGESHSLALSDRGQLFSWG 556
            G +Y  G N +GQLG   EG K   P    ALA    V +  GE    A++  G+L++ G
Sbjct: 3952 GTIYGWGHNHRGQLGGI-EGAKVKVPTPCEALATLRPVQLIGGEQTLFAVTADGKLYATG 4010

Query: 557  AGSDGQLGLMTTEESVAVPRLIQKLNQQTI--LQVSCGNWHCLALAADGQFFTWGKNSHG 730
             G+ G+LG+  TE SV+ P L++ +    I  + V+ G  HCLAL+++G+ ++WG+   G
Sbjct: 4011 YGAGGRLGIGGTE-SVSTPTLLESIQHVFIKKVAVNSGGKHCLALSSEGEVYSWGEAEDG 4069

Query: 731  QLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDE 910
            +LG G   P    P+ + SL GI +  VAAGGAHS  ++ +G ++ WG    G+LG SD 
Sbjct: 4070 KLGHGNRSPCDR-PRVIESLRGIEVVDVAAGGAHSACVTAAGDLYTWGKGRYGRLGHSDS 4128

Query: 911  EDRESPCHVKLLRAQKVVYISCG 979
            ED+  P  V+ L+  +VV I+CG
Sbjct: 4129 EDQLKPKLVEALQGHRVVDIACG 4151



 Score =  127 bits (318), Expect = 2e-29
 Identities = 82/261 (31%), Positives = 135/261 (51%), Gaps = 6/261 (2%)
 Frame = +2

Query: 242  GYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVAC--GGDHSVFLLEDGEVYTCGLNT 415
            GY + G+ GI       V+ P +   I    +K+VA   GG H + L  +GEVY+ G   
Sbjct: 4010 GYGAGGRLGIGGTES--VSTPTLLESIQHVFIKKVAVNSGGKHCLALSSEGEVYSWGEAE 4067

Query: 416  KGQLGHEREG--NKPEQIGALADEHIVHVACGESHSLALSDRGQLFSWGAGSDGQLGLMT 589
             G+LGH      ++P  I +L    +V VA G +HS  ++  G L++WG G  G+LG   
Sbjct: 4068 DGKLGHGNRSPCDRPRVIESLRGIEVVDVAAGGAHSACVTAAGDLYTWGKGRYGRLGHSD 4127

Query: 590  TEESVAVPRLIQKLNQQTILQVSCGNWHC--LALAADGQFFTWGKNSHGQLGLGKEFPSQ 763
            +E+ +  P+L++ L    ++ ++CG+     L L  D   ++WG   +G+LG G     +
Sbjct: 4128 SEDQLK-PKLVEALQGHRVVDIACGSGDAQTLCLTDDDTVWSWGDGDYGKLGRGGSDGCK 4186

Query: 764  ASPQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEEDRESPCHVKL 943
              P ++ SL G+ + +V  G   S AL+ SGAV+ WG  +  +LG   ++    P  V+ 
Sbjct: 4187 V-PMKIDSLTGLGVVKVECGSQFSVALTKSGAVYTWGKGDYHRLGHGSDDHVRRPRQVQG 4245

Query: 944  LRAQKVVYISCGEEHTAVLTK 1006
            L+ +KV+ I+ G  H    T+
Sbjct: 4246 LQGKKVIAIATGSLHCVCCTE 4266



 Score =  126 bits (317), Expect = 3e-29
 Identities = 81/261 (31%), Positives = 131/261 (50%), Gaps = 8/261 (3%)
 Frame = +2

Query: 221  TQTMLCWGYWSLGQPGISTNLQGIVAEPQVCGFISDRS----VKEVACGGDHSVFLLEDG 388
            T  +  WG    G+ G    +   + EP+V    S +     V  +ACG  +S  +  +G
Sbjct: 513  TGEVYSWGCGDGGRLGHGDTVP--LEEPKVISAFSGKQAGKHVVHIACGSTYSAAITAEG 570

Query: 389  EVYTCGLNTKGQLGHEREGNK--PEQIGALADEHIVHVACG--ESHSLALSDRGQLFSWG 556
            E+YT G    G+LGH    ++  P  +  L    ++ VACG  ++ +LA+++ GQ++SWG
Sbjct: 571  ELYTWGRGNYGRLGHGSSEDEAIPMLVAGLKGLKVIDVACGSGDAQTLAVTENGQVWSWG 630

Query: 557  AGSDGQLGLMTTEESVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQL 736
             G  G+LG     +    P+LI+KL    +++V CG+   +AL  DGQ ++WGK  + +L
Sbjct: 631  DGDYGKLG-RGGSDGCKTPKLIEKLQDLDVVKVRCGSQFSIALTKDGQVYSWGKGDNQRL 689

Query: 737  GLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEED 916
            G G E      P+ +  L+G  +  VAAG  H  AL+    V  WG N+  Q   +    
Sbjct: 690  GHGTE-EHVRYPKLLEGLQGKKVIDVAAGSTHCLALTEDSEVHSWGSNDQCQHFDTLRVT 748

Query: 917  RESPCHVKLLRAQKVVYISCG 979
            +  P  +  L  + +V I+CG
Sbjct: 749  KPEPAALPGLDTKHIVGIACG 769



 Score =  118 bits (295), Expect = 1e-26
 Identities = 71/245 (28%), Positives = 127/245 (51%), Gaps = 7/245 (2%)
 Frame = +2

Query: 293  VAEPQVCGFISDRSVKEVACGGDHSVFLLEDGEVYTCGLNTKGQLGHEREGNKPEQIGAL 472
            V  P  C  +++  V ++AC     + L  +G VYT   N+        +   P+ +  L
Sbjct: 439  VIGPIQCEGLANLGVTQIACAEKRFLILSRNGRVYTQAYNS--------DTLAPQLVQGL 490

Query: 473  ADEHIVHVACGES--HSLALSDRGQLFSWGAGSDGQLG---LMTTEESVAVPRLIQKLNQ 637
            A  +IV +A      H LAL+  G+++SWG G  G+LG    +  EE   +     K   
Sbjct: 491  ASRNIVKIAAHSDGHHYLALAATGEVYSWGCGDGGRLGHGDTVPLEEPKVISAFSGKQAG 550

Query: 638  QTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVA 817
            + ++ ++CG+ +  A+ A+G+ +TWG+ ++G+LG G     +A P  V  L+G+ +  VA
Sbjct: 551  KHVVHIACGSTYSAAITAEGELYTWGRGNYGRLGHGSS-EDEAIPMLVAGLKGLKVIDVA 609

Query: 818  --AGGAHSFALSLSGAVFGWGMNNAGQLGLSDEEDRESPCHVKLLRAQKVVYISCGEEHT 991
              +G A + A++ +G V+ WG  + G+LG    +  ++P  ++ L+   VV + CG + +
Sbjct: 610  CGSGDAQTLAVTENGQVWSWGDGDYGKLGRGGSDGCKTPKLIEKLQDLDVVKVRCGSQFS 669

Query: 992  AVLTK 1006
              LTK
Sbjct: 670  IALTK 674



 Score =  107 bits (268), Expect = 1e-23
 Identities = 65/209 (31%), Positives = 110/209 (52%), Gaps = 5/209 (2%)
 Frame = +2

Query: 389  EVYTCGLNTKGQLGHEREGNK---PEQIGALADEHIVHVACGESHSLALSDRGQLFSWGA 559
            +V+  GLN K QLG  + G+K   P     L+  ++V VA G     A++  G++++ G 
Sbjct: 2960 KVFVWGLNDKDQLGGLK-GSKIKVPSFSETLSALNVVQVAGGSKSLFAVTVEGKVYACGE 3018

Query: 560  GSDGQLGLMTTEESVAVPRLIQKLNQQTILQVS--CGNWHCLALAADGQFFTWGKNSHGQ 733
             ++G+LGL  +  +V +PR I  L+   + +V+   G  H  AL  DG+ F+WG+   G+
Sbjct: 3019 ATNGRLGLGISSGTVPIPRQITALSSYVVKKVAVHSGGRHATALTVDGKVFSWGEGDDGK 3078

Query: 734  LGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEE 913
            LG          P+ + +L+   +  +A G +HS AL+ SG ++ WG+   G+LG  D  
Sbjct: 3079 LGHFSRMNCD-KPRLIEALKTKRIRDIACGSSHSAALTSSGELYTWGLGEYGRLGHGDNT 3137

Query: 914  DRESPCHVKLLRAQKVVYISCGEEHTAVL 1000
             +  P  VK+L   +V+ ++CG      L
Sbjct: 3138 TQLKPKMVKVLLGHRVIQVACGSRDAQTL 3166



 Score =  103 bits (257), Expect = 3e-22
 Identities = 69/209 (33%), Positives = 113/209 (54%), Gaps = 4/209 (1%)
 Frame = +2

Query: 239  WGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACG-GD-HSVFLLEDGEVYTCGLN 412
            WG    G+ G S +   +  +P++   +    V ++ACG GD  ++ L +D  V++ G  
Sbjct: 4115 WGKGRYGRLGHSDSEDQL--KPKLVEALQGHRVVDIACGSGDAQTLCLTDDDTVWSWGDG 4172

Query: 413  TKGQLGHE-REGNK-PEQIGALADEHIVHVACGESHSLALSDRGQLFSWGAGSDGQLGLM 586
              G+LG    +G K P +I +L    +V V CG   S+AL+  G +++WG G   +LG  
Sbjct: 4173 DYGKLGRGGSDGCKVPMKIDSLTGLGVVKVECGSQFSVALTKSGAVYTWGKGDYHRLG-H 4231

Query: 587  TTEESVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQA 766
             +++ V  PR +Q L  + ++ ++ G+ HC+    DG+ +TWG N  GQLG G     Q 
Sbjct: 4232 GSDDHVRRPRQVQGLQGKKVIAIATGSLHCVCCTEDGEVYTWGDNDEGQLGDGTTNAIQR 4291

Query: 767  SPQRVRSLEGIPLAQVAAGGAHSFALSLS 853
             P+ V +L+G  + +VA G AH+ A S S
Sbjct: 4292 -PRLVAALQGKKVNRVACGSAHTLAWSTS 4319



 Score = 97.8 bits (242), Expect = 1e-20
 Identities = 68/207 (32%), Positives = 109/207 (52%), Gaps = 4/207 (1%)
 Frame = +2

Query: 239  WGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACG-GD-HSVFLLEDGEVYTCGLN 412
            WG  + G+ G  ++    +  P +   +    V +VACG GD  ++ + E+G+V++ G  
Sbjct: 575  WGRGNYGRLGHGSSEDEAI--PMLVAGLKGLKVIDVACGSGDAQTLAVTENGQVWSWGDG 632

Query: 413  TKGQLGHE-REGNK-PEQIGALADEHIVHVACGESHSLALSDRGQLFSWGAGSDGQLGLM 586
              G+LG    +G K P+ I  L D  +V V CG   S+AL+  GQ++SWG G + +LG  
Sbjct: 633  DYGKLGRGGSDGCKTPKLIEKLQDLDVVKVRCGSQFSIALTKDGQVYSWGKGDNQRLG-H 691

Query: 587  TTEESVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQA 766
             TEE V  P+L++ L  + ++ V+ G+ HCLAL  D +  +WG N   Q        ++ 
Sbjct: 692  GTEEHVRYPKLLEGLQGKKVIDVAAGSTHCLALTEDSEVHSWGSNDQCQ-HFDTLRVTKP 750

Query: 767  SPQRVRSLEGIPLAQVAAGGAHSFALS 847
             P  +  L+   +  +A G A SFA S
Sbjct: 751  EPAALPGLDTKHIVGIACGPAQSFAWS 777



 Score = 87.8 bits (216), Expect = 2e-17
 Identities = 56/193 (29%), Positives = 91/193 (47%), Gaps = 6/193 (3%)
 Frame = +2

Query: 452  PEQIGALADEHIVHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTEESVAVPRLIQKL 631
            P Q   LA+  +  +AC E   L LS  G++++    SD              P+L+Q L
Sbjct: 442  PIQCEGLANLGVTQIACAEKRFLILSRNGRVYTQAYNSD-----------TLAPQLVQGL 490

Query: 632  NQQTILQVSCGN--WHCLALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIP- 802
              + I++++  +   H LALAA G+ ++WG    G+LG G   P +  P+ + +  G   
Sbjct: 491  ASRNIVKIAAHSDGHHYLALAATGEVYSWGCGDGGRLGHGDTVPLE-EPKVISAFSGKQA 549

Query: 803  ---LAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEEDRESPCHVKLLRAQKVVYIS 973
               +  +A G  +S A++  G ++ WG  N G+LG    ED   P  V  L+  KV+ ++
Sbjct: 550  GKHVVHIACGSTYSAAITAEGELYTWGRGNYGRLGHGSSEDEAIPMLVAGLKGLKVIDVA 609

Query: 974  CGEEHTAVLTKVE 1012
            CG      L   E
Sbjct: 610  CGSGDAQTLAVTE 622



 Score = 87.4 bits (215), Expect = 2e-17
 Identities = 48/163 (29%), Positives = 91/163 (55%), Gaps = 2/163 (1%)
 Frame = +2

Query: 521  ALSDRGQLFSWGAGSDGQLGLMTTEESVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQ 700
            A + R ++F WG     QLG +   + + VP   + L+   ++QV+ G+    A+  +G+
Sbjct: 2954 AATIRTKVFVWGLNDKDQLGGLKGSK-IKVPSFSETLSALNVVQVAGGSKSLFAVTVEGK 3012

Query: 701  FFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVA--AGGAHSFALSLSGAVFGWG 874
             +  G+ ++G+LGLG    +   P+++ +L    + +VA  +GG H+ AL++ G VF WG
Sbjct: 3013 VYACGEATNGRLGLGISSGTVPIPRQITALSSYVVKKVAVHSGGRHATALTVDGKVFSWG 3072

Query: 875  MNNAGQLGLSDEEDRESPCHVKLLRAQKVVYISCGEEHTAVLT 1003
              + G+LG     + + P  ++ L+ +++  I+CG  H+A LT
Sbjct: 3073 EGDDGKLGHFSRMNCDKPRLIEALKTKRIRDIACGSSHSAALT 3115



 Score = 79.7 bits (195), Expect = 4e-15
 Identities = 58/206 (28%), Positives = 95/206 (46%), Gaps = 5/206 (2%)
 Frame = +2

Query: 203  CMTP*RTQTMLCWG---YWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGDHSVF 373
            C+T     T+  WG   Y  LG+ G           P     ++   V +V CG   SV 
Sbjct: 4159 CLTD--DDTVWSWGDGDYGKLGRGGSDG-----CKVPMKIDSLTGLGVVKVECGSQFSVA 4211

Query: 374  LLEDGEVYTCGLNTKGQLGHEREGN--KPEQIGALADEHIVHVACGESHSLALSDRGQLF 547
            L + G VYT G     +LGH  + +  +P Q+  L  + ++ +A G  H +  ++ G+++
Sbjct: 4212 LTKSGAVYTWGKGDYHRLGHGSDDHVRRPRQVQGLQGKKVIAIATGSLHCVCCTEDGEVY 4271

Query: 548  SWGAGSDGQLGLMTTEESVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSH 727
            +WG   +GQLG  TT  ++  PRL+  L  + + +V+CG+ H LA         W  +  
Sbjct: 4272 TWGDNDEGQLGDGTTN-AIQRPRLVAALQGKKVNRVACGSAHTLA---------WSTSKP 4321

Query: 728  GQLGLGKEFPSQASPQRVRSLEGIPL 805
               G   + P+Q  P     L+ IP+
Sbjct: 4322 ASAG---KLPAQV-PMEYNHLQEIPI 4343


>ref|NP_057407.2| E3 ISG15--protein ligase HERC5 [Homo sapiens].
          Length = 1024

 Score =  146 bits (368), Expect(2) = 7e-36
 Identities = 73/168 (43%), Positives = 106/168 (63%)
 Frame = +2

Query: 503  GESHSLALSDRGQLFSWGAGSDGQLGLMTTEESVAVPRLIQKLNQQTILQVSCGNWHCLA 682
            G  H L LS  G+ F +   S   L      ES+        L ++ I+Q++CG++H LA
Sbjct: 105  GAEHMLILSSDGKPFEYDNYSMKHLRF----ESI--------LQEKKIIQITCGDYHSLA 152

Query: 683  LAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLSGAV 862
            L+  G+ F WG+N HGQLG+G++FPS  +PQ V  L G+PLAQ++AG AHS ALS+SG +
Sbjct: 153  LSKGGELFAWGQNLHGQLGVGRKFPSTTTPQIVEHLAGVPLAQISAGEAHSMALSMSGNI 212

Query: 863  FGWGMNNAGQLGLSDEEDRESPCHVKLLRAQKVVYISCGEEHTAVLTK 1006
            + WG N  GQLGL   E ++ P  ++ L  QKV +++CG  H+A+LT+
Sbjct: 213  YSWGKNECGQLGLGHTESKDDPSLIEGLDNQKVEFVACGGSHSALLTQ 260



 Score = 23.5 bits (49), Expect(2) = 7e-36
 Identities = 10/17 (58%), Positives = 12/17 (70%)
 Frame = +1

Query: 1003 KSGGVFTFGAGSCGPLG 1053
            + G +FTFGAG  G LG
Sbjct: 260  QDGLLFTFGAGKHGQLG 276



 Score =  130 bits (328), Expect(2) = 6e-31
 Identities = 74/219 (33%), Positives = 111/219 (50%)
 Frame = +2

Query: 335 VKEVACGGDHSVFLLEDGEVYTCGLNTKGQLGHEREGNKPEQIGALADEHIVHVACGESH 514
           +  V  G +H + L  DG+ +     +   L  E           L ++ I+ + CG+ H
Sbjct: 99  IHSVDQGAEHMLILSSDGKPFEYDNYSMKHLRFE---------SILQEKKIIQITCGDYH 149

Query: 515 SLALSDRGQLFSWGAGSDGQLGLMTTEESVAVPRLIQKLNQQTILQVSCGNWHCLALAAD 694
           SLALS  G+LF+WG    GQLG+     S   P++++ L    + Q+S G  H +AL+  
Sbjct: 150 SLALSKGGELFAWGQNLHGQLGVGRKFPSTTTPQIVEHLAGVPLAQISAGEAHSMALSMS 209

Query: 695 GQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWG 874
           G  ++WGKN  GQLGLG    S+  P  +  L+   +  VA GG+HS  L+  G +F +G
Sbjct: 210 GNIYSWGKNECGQLGLG-HTESKDDPSLIEGLDNQKVEFVACGGSHSALLTQDGLLFTFG 268

Query: 875 MNNAGQLGLSDEEDRESPCHVKLLRAQKVVYISCGEEHT 991
               GQLG +  ++   PC V  L   +V  I+CG  HT
Sbjct: 269 AGKHGQLGHNSTQNELRPCLVAELVGYRVTQIACGRWHT 307



 Score = 22.3 bits (46), Expect(2) = 6e-31
 Identities = 9/15 (60%), Positives = 11/15 (73%)
 Frame = +1

Query: 1009 GGVFTFGAGSCGPLG 1053
            G VF+FG+G  G LG
Sbjct: 315  GKVFSFGSGKDGQLG 329



 Score =  126 bits (316), Expect = 4e-29
 Identities = 81/229 (35%), Positives = 120/229 (52%), Gaps = 4/229 (1%)
 Frame = +2

Query: 320 ISDRSVKEVACGGDHSVFLLEDGEVYTCGLNTKGQLGHERE---GNKPEQIGALADEHIV 490
           + ++ + ++ CG  HS+ L + GE++  G N  GQLG  R+      P+ +  LA   + 
Sbjct: 135 LQEKKIIQITCGDYHSLALSKGGELFAWGQNLHGQLGVGRKFPSTTTPQIVEHLAGVPLA 194

Query: 491 HVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTEESVAVPRLIQKLNQQTILQVSCGNW 670
            ++ GE+HS+ALS  G ++SWG    GQLGL  T ES   P LI+ L+ Q +  V+CG  
Sbjct: 195 QISAGEAHSMALSMSGNIYSWGKNECGQLGLGHT-ESKDDPSLIEGLDNQKVEFVACGGS 253

Query: 671 HCLALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFA-LS 847
           H   L  DG  FT+G   HGQLG      ++  P  V  L G  + Q+A G  H+ A +S
Sbjct: 254 HSALLTQDGLLFTFGAGKHGQLG-HNSTQNELRPCLVAELVGYRVTQIACGRWHTLAYVS 312

Query: 848 LSGAVFGWGMNNAGQLGLSDEEDRESPCHVKLLRAQKVVYISCGEEHTA 994
             G VF +G    GQLG     D+  P  VK+  ++++      E HT+
Sbjct: 313 DLGKVFSFGSGKDGQLGNGGTRDQLMPLPVKVSSSEELKL----ESHTS 357



 Score =  105 bits (262), Expect = 7e-23
 Identities = 61/175 (34%), Positives = 92/175 (52%), Gaps = 3/175 (1%)
 Frame = +2

Query: 230 MLCWGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGDHSVFLLEDGEVYTCGL 409
           +  WG    GQ G+          PQ+   ++   + +++ G  HS+ L   G +Y+ G 
Sbjct: 159 LFAWGQNLHGQLGVGRKFPSTTT-PQIVEHLAGVPLAQISAGEAHSMALSMSGNIYSWGK 217

Query: 410 NTKGQ--LGHEREGNKPEQIGALADEHIVHVACGESHSLALSDRGQLFSWGAGSDGQLGL 583
           N  GQ  LGH    + P  I  L ++ +  VACG SHS  L+  G LF++GAG  GQLG 
Sbjct: 218 NECGQLGLGHTESKDDPSLIEGLDNQKVEFVACGGSHSALLTQDGLLFTFGAGKHGQLGH 277

Query: 584 MTTEESVAVPRLIQKLNQQTILQVSCGNWHCLALAAD-GQFFTWGKNSHGQLGLG 745
            +T+  +  P L+ +L    + Q++CG WH LA  +D G+ F++G    GQLG G
Sbjct: 278 NSTQNELR-PCLVAELVGYRVTQIACGRWHTLAYVSDLGKVFSFGSGKDGQLGNG 331



 Score = 83.6 bits (205), Expect = 3e-16
 Identities = 53/178 (29%), Positives = 86/178 (48%), Gaps = 4/178 (2%)
 Frame = +2

Query: 239 WGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGDHSVFLLEDGEVYTCGLNTK 418
           WG    GQ G+         +P +   + ++ V+ VACGG HS  L +DG ++T G    
Sbjct: 215 WGKNECGQLGLGHTESK--DDPSLIEGLDNQKVEFVACGGSHSALLTQDGLLFTFGAGKH 272

Query: 419 GQLGHEREGN--KPEQIGALADEHIVHVACGESHSLA-LSDRGQLFSWGAGSDGQLGLMT 589
           GQLGH    N  +P  +  L    +  +ACG  H+LA +SD G++FS+G+G DGQLG   
Sbjct: 273 GQLGHNSTQNELRPCLVAELVGYRVTQIACGRWHTLAYVSDLGKVFSFGSGKDGQLGNGG 332

Query: 590 TEESVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQ-FFTWGKNSHGQLGLGKEFPS 760
           T + +    +    +++  L+        + +A   Q    W K  +  + L +  P+
Sbjct: 333 TRDQLMPLPVKVSSSEELKLESHTSEKELIMIAGGNQSILLWIKKENSYVNLKRTIPT 390


>ref|NP_001259.1| RCC1 and BTB domain-containing protein 2 [Homo sapiens].
          Length = 551

 Score =  145 bits (365), Expect = 8e-35
 Identities = 84/254 (33%), Positives = 135/254 (53%), Gaps = 12/254 (4%)
 Frame = +2

Query: 269 ISTNLQGIVAEPQVCGFISDRSV-----KEVAC----GGDHSVFLLEDGEVYTCGLNTKG 421
           + TN  G +    V   I  R +     K++AC     G H V    +GEV+T G N   
Sbjct: 70  LGTNCCGCLGLGDVQSTIEPRRLDSLNGKKIACLSYGSGPHIVLATTEGEVFTWGHNAYS 129

Query: 422 QLGH--EREGNKPEQIGA-LADEHIVHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTT 592
           QLG+     G  P  I   L+++ ++ VACG  HSL L+  G++F+WG  + GQ+G  +T
Sbjct: 130 QLGNGTTNHGLVPCHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGST 189

Query: 593 EESVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQASP 772
                  R+   L  + ++ ++CG   C+A+   G+ + WG N +GQLGLG    +Q +P
Sbjct: 190 VNQPIPRRVTGCLQNKVVVTIACGQMCCMAVVDTGEVYVWGYNGNGQLGLGNS-GNQPTP 248

Query: 773 QRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEEDRESPCHVKLLRA 952
            RV +L+GI + +VA G AH+  L+  G V+ WG N+ GQLG  ++ ++  P  V + + 
Sbjct: 249 CRVAALQGIRVQRVACGYAHTLVLTDEGQVYAWGANSYGQLGTGNKSNQSYPTPVTVEKD 308

Query: 953 QKVVYISCGEEHTA 994
           + +   +C   HT+
Sbjct: 309 RIIEIAACHSTHTS 322



 Score =  120 bits (302), Expect = 2e-27
 Identities = 68/220 (30%), Positives = 118/220 (53%), Gaps = 4/220 (1%)
 Frame = +2

Query: 356  GDHSVFLLEDGEVYTCGLNTKG--QLGHEREGNKPEQIGALADEHIVHVACGES-HSLAL 526
            G+  ++   + E++  G N  G   LG  +   +P ++ +L  + I  ++ G   H +  
Sbjct: 55   GNEVLYTTVNDEIFVLGTNCCGCLGLGDVQSTIEPRRLDSLNGKKIACLSYGSGPHIVLA 114

Query: 527  SDRGQLFSWGAGSDGQLGLMTTEESVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFF 706
            +  G++F+WG  +  QLG  TT   +    +   L+ + +++V+CG++H L L +DG+ F
Sbjct: 115  TTEGEVFTWGHNAYSQLGNGTTNHGLVPCHISTNLSNKQVIEVACGSYHSLVLTSDGEVF 174

Query: 707  TWGKNSHGQLGLGKEFPSQASPQRVRS-LEGIPLAQVAAGGAHSFALSLSGAVFGWGMNN 883
             WG N+ GQ+G G    +Q  P+RV   L+   +  +A G     A+  +G V+ WG N 
Sbjct: 175  AWGYNNSGQVGSGSTV-NQPIPRRVTGCLQNKVVVTIACGQMCCMAVVDTGEVYVWGYNG 233

Query: 884  AGQLGLSDEEDRESPCHVKLLRAQKVVYISCGEEHTAVLT 1003
             GQLGL +  ++ +PC V  L+  +V  ++CG  HT VLT
Sbjct: 234  NGQLGLGNSGNQPTPCRVAALQGIRVQRVACGYAHTLVLT 273



 Score = 59.3 bits (142), Expect = 6e-09
 Identities = 39/121 (32%), Positives = 57/121 (47%), Gaps = 3/121 (2%)
 Frame = +2

Query: 203 CMTP*RTQTMLCWGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGDHSVFLLE 382
           CM    T  +  WGY   GQ G+  +  G    P     +    V+ VACG  H++ L +
Sbjct: 217 CMAVVDTGEVYVWGYNGNGQLGLGNS--GNQPTPCRVAALQGIRVQRVACGYAHTLVLTD 274

Query: 383 DGEVYTCGLNTKGQLGHEREGNK--PEQIGALADEHIVHVACGESH-SLALSDRGQLFSW 553
           +G+VY  G N+ GQLG   + N+  P  +    D  I   AC  +H S A +  G ++ W
Sbjct: 275 EGQVYAWGANSYGQLGTGNKSNQSYPTPVTVEKDRIIEIAACHSTHTSAAKTQGGHVYMW 334

Query: 554 G 556
           G
Sbjct: 335 G 335


>ref|NP_060661.3| RCC1 and BTB domain-containing protein 1 [Homo sapiens].
          Length = 531

 Score =  137 bits (346), Expect = 1e-32
 Identities = 77/233 (33%), Positives = 129/233 (55%), Gaps = 4/233 (1%)
 Frame = +2

Query: 308 VCGFISDRSVKEVACG-GDHSVFLLEDGEVYTCGLNTKGQLGH--EREGNKPEQIGA-LA 475
           +CG    + +K ++ G G H +   EDG VY  G N   QLG+    +G  P Q+   L 
Sbjct: 71  LCG----KKIKSLSYGSGPHVLLSTEDGVVYAWGHNGYSQLGNGTTNQGIAPVQVCTNLL 126

Query: 476 DEHIVHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTEESVAVPRLIQKLNQQTILQV 655
            + +V VACG  HS+AL+  G++F+WG  + GQ+G  +T       ++   L+ + ++ +
Sbjct: 127 IKQVVEVACGSHHSMALAADGEVFAWGYNNCGQVGSGSTANQPTPRKVTNCLHIKRVVGI 186

Query: 656 SCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHS 835
           +CG    +A+  +G+ + WG N +GQLGLG    +Q +P RV +L  + + Q+  G AH+
Sbjct: 187 ACGQTSSMAVLDNGEVYGWGYNGNGQLGLGNN-GNQLTPVRVAALHSVCVNQIVCGYAHT 245

Query: 836 FALSLSGAVFGWGMNNAGQLGLSDEEDRESPCHVKLLRAQKVVYISCGEEHTA 994
            AL+  G ++ WG N  GQLG  ++ +  SP H+ + + + V   +C   HT+
Sbjct: 246 LALTDEGLLYAWGANTYGQLGTGNKNNLLSPAHIMVEKERVVEIAACHSAHTS 298



 Score =  124 bits (312), Expect = 1e-28
 Identities = 77/216 (35%), Positives = 112/216 (51%), Gaps = 4/216 (1%)
 Frame = +2

Query: 239 WGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGDHSVFLLEDGEVYTCGLNTK 418
           WG+    Q G  T  QGI A  QVC  +  + V EVACG  HS+ L  DGEV+  G N  
Sbjct: 99  WGHNGYSQLGNGTTNQGI-APVQVCTNLLIKQVVEVACGSHHSMALAADGEVFAWGYNNC 157

Query: 419 GQLGHEREGNKP---EQIGALADEHIVHVACGESHSLALSDRGQLFSWGAGSDGQLGLMT 589
           GQ+G     N+P   +    L  + +V +ACG++ S+A+ D G+++ WG   +GQLGL  
Sbjct: 158 GQVGSGSTANQPTPRKVTNCLHIKRVVGIACGQTSSMAVLDNGEVYGWGYNGNGQLGLGN 217

Query: 590 TEESVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQAS 769
               +  P  +  L+   + Q+ CG  H LAL  +G  + WG N++GQLG G +  +  S
Sbjct: 218 NGNQL-TPVRVAALHSVCVNQIVCGYAHTLALTDEGLLYAWGANTYGQLGTGNK-NNLLS 275

Query: 770 PQRVRSLEGIPLAQVAAGGAH-SFALSLSGAVFGWG 874
           P  +   +   +   A   AH S A +  G V+ WG
Sbjct: 276 PAHIMVEKERVVEIAACHSAHTSAAKTQGGHVYMWG 311



 Score =  118 bits (295), Expect = 1e-26
 Identities = 71/217 (32%), Positives = 119/217 (54%), Gaps = 4/217 (1%)
 Frame = +2

Query: 365  SVFLLEDGEVYTCGLNTKGQLG--HEREGNKPEQIGALADEHIVHVACGES-HSLALSDR 535
            ++++ ++ EV+  GLN    LG    +    P+++  L  + I  ++ G   H L  ++ 
Sbjct: 34   ALYVTDNDEVFVFGLNYSNCLGTGDNQSTLVPKKLEGLCGKKIKSLSYGSGPHVLLSTED 93

Query: 536  GQLFSWGAGSDGQLGLMTTEESVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWG 715
            G +++WG     QLG  TT + +A  ++   L  + +++V+CG+ H +ALAADG+ F WG
Sbjct: 94   GVVYAWGHNGYSQLGNGTTNQGIAPVQVCTNLLIKQVVEVACGSHHSMALAADGEVFAWG 153

Query: 716  KNSHGQLGLGKEFPSQASPQRVRSLEGIP-LAQVAAGGAHSFALSLSGAVFGWGMNNAGQ 892
             N+ GQ+G G    +Q +P++V +   I  +  +A G   S A+  +G V+GWG N  GQ
Sbjct: 154  YNNCGQVGSGST-ANQPTPRKVTNCLHIKRVVGIACGQTSSMAVLDNGEVYGWGYNGNGQ 212

Query: 893  LGLSDEEDRESPCHVKLLRAQKVVYISCGEEHTAVLT 1003
            LGL +  ++ +P  V  L +  V  I CG  HT  LT
Sbjct: 213  LGLGNNGNQLTPVRVAALHSVCVNQIVCGYAHTLALT 249


>ref|NP_000319.1| X-linked retinitis pigmentosa GTPase regulator isoform A [Homo
            sapiens].
          Length = 815

 Score =  131 bits (330), Expect = 9e-31
 Identities = 87/262 (33%), Positives = 135/262 (51%), Gaps = 5/262 (1%)
 Frame = +2

Query: 239  WGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGDHSVFLLEDGEVYTCGLNTK 418
            WG   LG        +  +++P     +    VK  ACG +H++   E G VY  G N +
Sbjct: 64   WGQLGLGS-------KSAISKPTCVKALKPEKVKLAACGRNHTLVSTEGGNVYATGGNNE 116

Query: 419  GQ--LGHEREGNKPEQIGALADEH-IVHVACGESHSLALSDRGQLFSWGAGSDGQLGLMT 589
            GQ  LG   E N    I     EH I  ++ G + S AL++ G+LF WG  S+GQ+GL  
Sbjct: 117  GQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDGRLFMWGDNSEGQIGLKN 176

Query: 590  TEESVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKE-FPSQA 766
               +V VP+  Q    + +  +SCG +H   +  DG+ + +G+  +G+LGL  +   +  
Sbjct: 177  V-SNVCVPQ--QVTIGKPVSWISCGYYHSAFVTTDGELYVFGEPENGKLGLPNQLLGNHR 233

Query: 767  SPQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSD-EEDRESPCHVKL 943
            +PQ V  +    + QVA GG H+  L+   AV+ +G+   GQLGL     +   P  ++ 
Sbjct: 234  TPQLVSEIPE-KVIQVACGGEHTVVLT-ENAVYTFGLGQFGQLGLGTFLFETSEPKVIEN 291

Query: 944  LRAQKVVYISCGEEHTAVLTKV 1009
            +R Q + YISCGE HTA++T +
Sbjct: 292  IRDQTISYISCGENHTALITDI 313



 Score =  120 bits (301), Expect = 2e-27
 Identities = 75/225 (33%), Positives = 124/225 (55%), Gaps = 4/225 (1%)
 Frame = +2

Query: 344  VACGGDHSVFLLEDGEVYTCGLNTKGQLGHEREG--NKPEQIGALADEHIVHVACGESHS 517
            ++CG +HS  +  + ++Y  G N  GQLG   +   +KP  + AL  E +   ACG +H+
Sbjct: 40   LSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHT 99

Query: 518  LALSDRGQLFSWGAGSDGQLGLMTTEESVAVPRLIQKLNQQTILQVSCGNWHCLALAADG 697
            L  ++ G +++ G  ++GQLGL  TEE      +    ++  I Q+S G+    AL  DG
Sbjct: 100  LVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDG 159

Query: 698  QFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGM 877
            + F WG NS GQ+GL K   +   PQ+V    G P++ ++ G  HS  ++  G ++ +G 
Sbjct: 160  RLFMWGDNSEGQIGL-KNVSNVCVPQQVTI--GKPVSWISCGYYHSAFVTTDGELYVFGE 216

Query: 878  NNAGQLGLSDE--EDRESPCHVKLLRAQKVVYISCGEEHTAVLTK 1006
               G+LGL ++   +  +P  V  +  +KV+ ++CG EHT VLT+
Sbjct: 217  PENGKLGLPNQLLGNHRTPQLVSEI-PEKVIQVACGGEHTVVLTE 260



 Score =  102 bits (254), Expect = 6e-22
 Identities = 65/205 (31%), Positives = 103/205 (50%), Gaps = 4/205 (1%)
 Frame = +2

Query: 230 MLCWGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGDHSVFLLEDGEVYTCGL 409
           +  WG  S GQ G+  N+  +    QV      + V  ++CG  HS F+  DGE+Y  G 
Sbjct: 161 LFMWGDNSEGQIGLK-NVSNVCVPQQVT---IGKPVSWISCGYYHSAFVTTDGELYVFGE 216

Query: 410 NTKGQLGHERE---GNKPEQIGALADEHIVHVACGESHSLALSDRGQLFSWGAGSDGQLG 580
              G+LG   +    ++  Q+ +   E ++ VACG  H++ L++   ++++G G  GQLG
Sbjct: 217 PENGKLGLPNQLLGNHRTPQLVSEIPEKVIQVACGGEHTVVLTENA-VYTFGLGQFGQLG 275

Query: 581 LMTTEESVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKE-FP 757
           L T     + P++I+ +  QTI  +SCG  H   +   G  +T+G   HG+LGLG E F 
Sbjct: 276 LGTFLFETSEPKVIENIRDQTISYISCGENHTALITDIGLMYTFGDGRHGKLGLGLENFT 335

Query: 758 SQASPQRVRSLEGIPLAQVAAGGAH 832
           +   P    +     +  VA GG H
Sbjct: 336 NHFIPTLCSNFLRFIVKLVACGGCH 360



 Score = 90.1 bits (222), Expect = 3e-18
 Identities = 54/201 (26%), Positives = 109/201 (54%), Gaps = 3/201 (1%)
 Frame = +2

Query: 317 FISDRSVKEVACGGDHSVFLLEDGEVYTCGLNTKGQLGHEREGNK--PEQIGALADEHIV 490
           F S+  +K+++ G + S  L EDG ++  G N++GQ+G +   N   P+Q+     + + 
Sbjct: 136 FTSEHKIKQLSAGSNTSAALTEDGRLFMWGDNSEGQIGLKNVSNVCVPQQV--TIGKPVS 193

Query: 491 HVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTE-ESVAVPRLIQKLNQQTILQVSCGN 667
            ++CG  HS  ++  G+L+ +G   +G+LGL      +   P+L+ ++ ++ ++QV+CG 
Sbjct: 194 WISCGYYHSAFVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQLVSEIPEK-VIQVACGG 252

Query: 668 WHCLALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALS 847
            H + L  +   +T+G    GQLGLG      + P+ + ++    ++ ++ G  H+  ++
Sbjct: 253 EHTVVLT-ENAVYTFGLGQFGQLGLGTFLFETSEPKVIENIRDQTISYISCGENHTALIT 311

Query: 848 LSGAVFGWGMNNAGQLGLSDE 910
             G ++ +G    G+LGL  E
Sbjct: 312 DIGLMYTFGDGRHGKLGLGLE 332



 Score = 89.7 bits (221), Expect = 4e-18
 Identities = 53/172 (30%), Positives = 89/172 (51%)
 Frame = +2

Query: 488  VHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTEESVAVPRLIQKLNQQTILQVSCGN 667
            VH++CG+ HS  ++   +L+ +G+ + GQLGL  ++ +++ P  ++ L  + +   +CG 
Sbjct: 38   VHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGL-GSKSAISKPTCVKALKPEKVKLAACGR 96

Query: 668  WHCLALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALS 847
             H L     G  +  G N+ GQLGLG                   + Q++AG   S AL+
Sbjct: 97   NHTLVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALT 156

Query: 848  LSGAVFGWGMNNAGQLGLSDEEDRESPCHVKLLRAQKVVYISCGEEHTAVLT 1003
              G +F WG N+ GQ+GL +  +   P  V +   + V +ISCG  H+A +T
Sbjct: 157  EDGRLFMWGDNSEGQIGLKNVSNVCVPQQVTI--GKPVSWISCGYYHSAFVT 206



 Score = 50.4 bits (119), Expect = 3e-06
 Identities = 31/104 (29%), Positives = 48/104 (46%)
 Frame = +2

Query: 695  GQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWG 874
            G  FT+GK+   +   GK +     P             ++ G  HS  ++ +  ++ +G
Sbjct: 12   GAVFTFGKSKFAENNPGKFWFKNDVP-----------VHLSCGDEHSAVVTGNNKLYMFG 60

Query: 875  MNNAGQLGLSDEEDRESPCHVKLLRAQKVVYISCGEEHTAVLTK 1006
             NN GQLGL  +     P  VK L+ +KV   +CG  HT V T+
Sbjct: 61   SNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHTLVSTE 104


  Database: RefSeq49_HP.fasta
    Posted date:  Oct 17, 2011  1:42 PM
  Number of letters in database: 18,297,164
  Number of sequences in database:  32,964
  
Lambda     K      H
   0.318    0.134    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 32964
Number of Hits to DB: 50,560,901
Number of extensions: 1608006
Number of successful extensions: 8229
Number of sequences better than 1.0e-05: 30
Number of HSP's gapped: 7731
Number of HSP's successfully gapped: 152
Length of query: 351
Length of database: 18,297,164
Length adjustment: 103
Effective length of query: 248
Effective length of database: 14,901,872
Effective search space: 3695664256
Effective search space used: 3695664256
Neighboring words threshold: 12
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 35 (18.1 bits)

BLASTX 2.2.24 [Aug-08-2010]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= 20110601C-003003
         (1053 letters)

Database: RefSeq49_MP.fasta 
           30,036 sequences; 15,617,559 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

Alignment   gi|NP_082981.3| hect domain and RLD 3 [Mus musculus].                520   e-152
Alignment   gi|NP_084390.1| probable E3 ubiquitin-protein ligase HERC4 isof...   303   7e-85
Alignment   gi|NP_080377.2| probable E3 ubiquitin-protein ligase HERC4 isof...   303   7e-85
Alignment   gi|NP_080268.1| hect domain and RLD 5 [Mus musculus].                235   5e-62
Alignment   gi|NP_034548.2| E3 ubiquitin-protein ligase HERC2 [Mus musculus].    164   1e-40
Alignment   gi|NP_001164165.1| RCC1 and BTB domain-containing protein 2 [Mu...   142   4e-34
Alignment   gi|NP_598844.3| RCC1 and BTB domain-containing protein 2 [Mus m...   142   4e-34
Alignment   gi|NP_082040.2| RCC1 and BTB domain-containing protein 1 [Mus m...   137   1e-32
Alignment   gi|NP_663592.3| hect domain and RCC1-like domain 1 [Mus musculu...   129   4e-30
Alignment   gi|NP_001171424.1| X-linked retinitis pigmentosa GTPase regulat...   127   1e-29

>ref|NP_082981.3| hect domain and RLD 3 [Mus musculus].
          Length = 1050

 Score =  520 bits (1338), Expect(2) = e-152
 Identities = 247/259 (95%), Positives = 256/259 (98%)
 Frame = +2

Query: 230  MLCWGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGDHSVFLLEDGEVYTCGL 409
            MLCWGYWSLGQPGIS+NLQGIVAEPQVC F+SDRS+KEVACGG+HSVFLLEDGEVYTCG+
Sbjct: 1    MLCWGYWSLGQPGISSNLQGIVAEPQVCRFVSDRSIKEVACGGNHSVFLLEDGEVYTCGV 60

Query: 410  NTKGQLGHEREGNKPEQIGALADEHIVHVACGESHSLALSDRGQLFSWGAGSDGQLGLMT 589
            NTKGQLGHEREGNKPEQIGALAD+HI+HVACGESHSLALSDRGQLFSWGAGSDGQLGLMT
Sbjct: 61   NTKGQLGHEREGNKPEQIGALADQHIIHVACGESHSLALSDRGQLFSWGAGSDGQLGLMT 120

Query: 590  TEESVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQAS 769
            TE+SVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQ S
Sbjct: 121  TEDSVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQTS 180

Query: 770  PQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEEDRESPCHVKLLR 949
            PQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDE+DRESPCHVKLLR
Sbjct: 181  PQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEKDRESPCHVKLLR 240

Query: 950  AQKVVYISCGEEHTAVLTK 1006
             QKVVYISCGEEHTAVLTK
Sbjct: 241  TQKVVYISCGEEHTAVLTK 259



 Score = 37.7 bits (86), Expect(2) = e-152
 Identities = 16/17 (94%), Positives = 16/17 (94%)
 Frame = +1

Query: 1003 KSGGVFTFGAGSCGPLG 1053
            KSGGVFTFGAGSCG LG
Sbjct: 259  KSGGVFTFGAGSCGQLG 275



 Score = 66.6 bits (161), Expect = 3e-11
 Identities = 37/117 (31%), Positives = 61/117 (52%), Gaps = 3/117 (2%)
 Frame = +2

Query: 239 WGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGDHSVFLLEDGEVYTCGLNTK 418
           WG  + GQ G+S         P     +  + V  ++CG +H+  L + G V+T G  + 
Sbjct: 214 WGMNNAGQLGLSDEKDR--ESPCHVKLLRTQKVVYISCGEEHTAVLTKSGGVFTFGAGSC 271

Query: 419 GQLGHEREGNK--PEQIGALADEHIVHVACGESHSLAL-SDRGQLFSWGAGSDGQLG 580
           GQLGH+   ++  P ++  L    +  +ACG  H+LAL    G ++++G G+ GQLG
Sbjct: 272 GQLGHDSVNDEVNPRRVLELMGSEVTQIACGRQHTLALVPSSGLIYAFGCGAKGQLG 328


>ref|NP_084390.1| probable E3 ubiquitin-protein ligase HERC4 isoform 1 [Mus musculus].
          Length = 1057

 Score =  303 bits (775), Expect(2) = 7e-85
 Identities = 147/259 (56%), Positives = 189/259 (72%)
 Frame = +2

Query: 230  MLCWGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGDHSVFLLEDGEVYTCGL 409
            MLCWG  S GQ G+    + IV EP+   F  ++ V++V CG  H+VF+L+DG VYTCG 
Sbjct: 1    MLCWGNASYGQLGLGGIDEEIVLEPRRSDFFVNKKVRDVGCGLRHTVFVLDDGTVYTCGC 60

Query: 410  NTKGQLGHEREGNKPEQIGALADEHIVHVACGESHSLALSDRGQLFSWGAGSDGQLGLMT 589
            N  GQLGHE+   KPEQ+ AL  ++IV VACGE+H+LAL+D+GQ+++WG  SDGQLGL  
Sbjct: 61   NDLGQLGHEKSRKKPEQVVALDAQNIVAVACGEAHTLALNDKGQVYAWGLDSDGQLGLQG 120

Query: 590  TEESVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQAS 769
            +EE + VPR I+ L+   I+QV+CG +H LAL+   + F WG+N +GQLGLG +   Q S
Sbjct: 121  SEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGIDCQKQTS 180

Query: 770  PQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEEDRESPCHVKLLR 949
            PQ ++SL GIP  QVAAGGAHSF L+LSGA+FGWG N  GQLGL+DE DR  P  +K LR
Sbjct: 181  PQLIKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLR 240

Query: 950  AQKVVYISCGEEHTAVLTK 1006
            +QK+VYI CGE+HTA LTK
Sbjct: 241  SQKIVYICCGEDHTAALTK 259



 Score = 30.4 bits (67), Expect(2) = 7e-85
 Identities = 13/17 (76%), Positives = 13/17 (76%)
 Frame = +1

Query: 1003 KSGGVFTFGAGSCGPLG 1053
            K GGVFTFGAG  G LG
Sbjct: 259  KEGGVFTFGAGGYGQLG 275



 Score =  128 bits (322), Expect = 7e-30
 Identities = 85/238 (35%), Positives = 123/238 (51%), Gaps = 4/238 (1%)
 Frame = +2

Query: 239 WGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGDHSVFLLEDGEVYTCGLNTK 418
           WG  S GQ G+  + +  +  P+    +SD  + +VACG  HS+ L +  EV+  G N  
Sbjct: 108 WGLDSDGQLGLQGS-EECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKY 166

Query: 419 GQLGHEREGNK---PEQIGALADEHIVHVACGESHSLALSDRGQLFSWGAGSDGQLGLMT 589
           GQLG   +  K   P+ I +L     + VA G +HS  L+  G +F WG    GQLGL  
Sbjct: 167 GQLGLGIDCQKQTSPQLIKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGL-N 225

Query: 590 TEESVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQAS 769
            E    VP L++ L  Q I+ + CG  H  AL  +G  FT+G   +GQLG       + +
Sbjct: 226 DENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNST-SHEIN 284

Query: 770 PQRVRSLEGIPLAQVAAGGAHSFA-LSLSGAVFGWGMNNAGQLGLSDEEDRESPCHVK 940
           P++V  L G  + QVA G  H+ A +  SG ++ +G+   GQLG     +R+SP  VK
Sbjct: 285 PRKVFELMGSIVTQVACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRKSPFTVK 342



 Score =  102 bits (255), Expect = 4e-22
 Identities = 67/225 (29%), Positives = 111/225 (49%), Gaps = 17/225 (7%)
 Frame = +2

Query: 218 RTQTMLCWGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGDHSVFLLEDGEVY 397
           +   + CWG    GQ G+  + Q   + PQ+   +      +VA GG HS  L   G ++
Sbjct: 154 KASEVFCWGQNKYGQLGLGIDCQKQTS-PQLIKSLLGIPFMQVAAGGAHSFVLTLSGAIF 212

Query: 398 TCGLNTKGQLGHEREGNK--PEQIGALADEHIVHVACGESHSLALSDRGQLFSWGAGSDG 571
             G N  GQLG   E ++  P  + +L  + IV++ CGE H+ AL+  G +F++GAG  G
Sbjct: 213 GWGRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYG 272

Query: 572 QLGLMTTEESVAVPRLIQKLNQQTILQVSCGNWHCLA-LAADGQFFTWGKNSHGQLGLGK 748
           QLG  +T   +  PR + +L    + QV+CG  H  A + + G+ +++G   +GQLG G 
Sbjct: 273 QLGHNSTSHEIN-PRKVFELMGSIVTQVACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGS 331

Query: 749 EFPSQA--------------SPQRVRSLEGIPLAQVAAGGAHSFA 841
               ++               PQ + S +   + ++ +GG  SF+
Sbjct: 332 TSNRKSPFTVKGNWFSYNGQCPQDIGSEDYFCVKRIFSGGDQSFS 376


>ref|NP_080377.2| probable E3 ubiquitin-protein ligase HERC4 isoform 2 [Mus musculus].
          Length = 1049

 Score =  303 bits (775), Expect(2) = 7e-85
 Identities = 147/259 (56%), Positives = 189/259 (72%)
 Frame = +2

Query: 230  MLCWGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGDHSVFLLEDGEVYTCGL 409
            MLCWG  S GQ G+    + IV EP+   F  ++ V++V CG  H+VF+L+DG VYTCG 
Sbjct: 1    MLCWGNASYGQLGLGGIDEEIVLEPRRSDFFVNKKVRDVGCGLRHTVFVLDDGTVYTCGC 60

Query: 410  NTKGQLGHEREGNKPEQIGALADEHIVHVACGESHSLALSDRGQLFSWGAGSDGQLGLMT 589
            N  GQLGHE+   KPEQ+ AL  ++IV VACGE+H+LAL+D+GQ+++WG  SDGQLGL  
Sbjct: 61   NDLGQLGHEKSRKKPEQVVALDAQNIVAVACGEAHTLALNDKGQVYAWGLDSDGQLGLQG 120

Query: 590  TEESVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQAS 769
            +EE + VPR I+ L+   I+QV+CG +H LAL+   + F WG+N +GQLGLG +   Q S
Sbjct: 121  SEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGIDCQKQTS 180

Query: 770  PQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEEDRESPCHVKLLR 949
            PQ ++SL GIP  QVAAGGAHSF L+LSGA+FGWG N  GQLGL+DE DR  P  +K LR
Sbjct: 181  PQLIKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLR 240

Query: 950  AQKVVYISCGEEHTAVLTK 1006
            +QK+VYI CGE+HTA LTK
Sbjct: 241  SQKIVYICCGEDHTAALTK 259



 Score = 30.4 bits (67), Expect(2) = 7e-85
 Identities = 13/17 (76%), Positives = 13/17 (76%)
 Frame = +1

Query: 1003 KSGGVFTFGAGSCGPLG 1053
            K GGVFTFGAG  G LG
Sbjct: 259  KEGGVFTFGAGGYGQLG 275



 Score =  128 bits (322), Expect = 7e-30
 Identities = 85/238 (35%), Positives = 123/238 (51%), Gaps = 4/238 (1%)
 Frame = +2

Query: 239 WGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGDHSVFLLEDGEVYTCGLNTK 418
           WG  S GQ G+  + +  +  P+    +SD  + +VACG  HS+ L +  EV+  G N  
Sbjct: 108 WGLDSDGQLGLQGS-EECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKY 166

Query: 419 GQLGHEREGNK---PEQIGALADEHIVHVACGESHSLALSDRGQLFSWGAGSDGQLGLMT 589
           GQLG   +  K   P+ I +L     + VA G +HS  L+  G +F WG    GQLGL  
Sbjct: 167 GQLGLGIDCQKQTSPQLIKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGL-N 225

Query: 590 TEESVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQAS 769
            E    VP L++ L  Q I+ + CG  H  AL  +G  FT+G   +GQLG       + +
Sbjct: 226 DENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNST-SHEIN 284

Query: 770 PQRVRSLEGIPLAQVAAGGAHSFA-LSLSGAVFGWGMNNAGQLGLSDEEDRESPCHVK 940
           P++V  L G  + QVA G  H+ A +  SG ++ +G+   GQLG     +R+SP  VK
Sbjct: 285 PRKVFELMGSIVTQVACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRKSPFTVK 342



 Score =  102 bits (255), Expect = 4e-22
 Identities = 67/225 (29%), Positives = 111/225 (49%), Gaps = 17/225 (7%)
 Frame = +2

Query: 218 RTQTMLCWGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGDHSVFLLEDGEVY 397
           +   + CWG    GQ G+  + Q   + PQ+   +      +VA GG HS  L   G ++
Sbjct: 154 KASEVFCWGQNKYGQLGLGIDCQKQTS-PQLIKSLLGIPFMQVAAGGAHSFVLTLSGAIF 212

Query: 398 TCGLNTKGQLGHEREGNK--PEQIGALADEHIVHVACGESHSLALSDRGQLFSWGAGSDG 571
             G N  GQLG   E ++  P  + +L  + IV++ CGE H+ AL+  G +F++GAG  G
Sbjct: 213 GWGRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYG 272

Query: 572 QLGLMTTEESVAVPRLIQKLNQQTILQVSCGNWHCLA-LAADGQFFTWGKNSHGQLGLGK 748
           QLG  +T   +  PR + +L    + QV+CG  H  A + + G+ +++G   +GQLG G 
Sbjct: 273 QLGHNSTSHEIN-PRKVFELMGSIVTQVACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGS 331

Query: 749 EFPSQA--------------SPQRVRSLEGIPLAQVAAGGAHSFA 841
               ++               PQ + S +   + ++ +GG  SF+
Sbjct: 332 TSNRKSPFTVKGNWFSYNGQCPQDIGSEDYFCVKRIFSGGDQSFS 376


>ref|NP_080268.1| hect domain and RLD 5 [Mus musculus].
          Length = 1003

 Score =  235 bits (599), Expect = 5e-62
 Identities = 121/227 (53%), Positives = 159/227 (70%), Gaps = 5/227 (2%)
 Frame = +2

Query: 341  EVACGGDHSVFLLEDGEVYTCGLNTKGQLGHEREGN--KPEQIGALADEHIVHVACGESH 514
            + A G  HS+ L  +  VY+CG N+ GQLG  R+ +  +PE I AL D H+  V+CG+ H
Sbjct: 26   QAASGEHHSLLLFSNHRVYSCGDNSWGQLGQRRDQSTERPEPIQALNDLHVDLVSCGKEH 85

Query: 515  SLALSDRGQLFSWGAGSDGQLGLMTTEESVAVPRLIQKLNQQTILQVSCGNWHCLALAAD 694
            S+A+  +G++F+WGAGS+GQLG+   +E   +P  I+ L    I+QVSCG++H LAL+ D
Sbjct: 86   SVAVCHKGKVFAWGAGSEGQLGIGEFKEISFMPTKIKALAGIKIIQVSCGHYHSLALSED 145

Query: 695  GQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWG 874
            G  F+WG+NS GQLGLGK   SQA PQ+V+SLEGIPLAQVAAGG HSFALSL+G  FGWG
Sbjct: 146  GHVFSWGRNSEGQLGLGKNSRSQAIPQKVKSLEGIPLAQVAAGGTHSFALSLTGTSFGWG 205

Query: 875  MNNAGQLGLSDEEDRE---SPCHVKLLRAQKVVYISCGEEHTAVLTK 1006
             N +GQL LS  + +E    P  +  L+   V+YISCG EHTAVLT+
Sbjct: 206  SNRSGQLALSGNKVKEQIYKPHSIGALKNLSVIYISCGYEHTAVLTE 252



 Score =  139 bits (349), Expect = 5e-33
 Identities = 83/235 (35%), Positives = 125/235 (53%), Gaps = 5/235 (2%)
 Frame = +2

Query: 302 PQVCGFISDRSVKEVACGGDHSVFLLEDGEVYTCGLNTKGQLG---HEREGNKPEQIGAL 472
           P+    ++D  V  V+CG +HSV +   G+V+  G  ++GQLG    +     P +I AL
Sbjct: 65  PEPIQALNDLHVDLVSCGKEHSVAVCHKGKVFAWGAGSEGQLGIGEFKEISFMPTKIKAL 124

Query: 473 ADEHIVHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTEESVAVPRLIQKLNQQTILQ 652
           A   I+ V+CG  HSLALS+ G +FSWG  S+GQLGL     S A+P+ ++ L    + Q
Sbjct: 125 AGIKIIQVSCGHYHSLALSEDGHVFSWGRNSEGQLGLGKNSRSQAIPQKVKSLEGIPLAQ 184

Query: 653 VSCGNWHCLALAADGQFFTWGKNSHGQLGL-GKEFPSQA-SPQRVRSLEGIPLAQVAAGG 826
           V+ G  H  AL+  G  F WG N  GQL L G +   Q   P  + +L+ + +  ++ G 
Sbjct: 185 VAAGGTHSFALSLTGTSFGWGSNRSGQLALSGNKVKEQIYKPHSIGALKNLSVIYISCGY 244

Query: 827 AHSFALSLSGAVFGWGMNNAGQLGLSDEEDRESPCHVKLLRAQKVVYISCGEEHT 991
            H+  L+  G VF +G N++GQL  S    +  P  ++ +   +V  I C   HT
Sbjct: 245 EHTAVLTEEGQVFTFGGNSSGQLQPSPRSGQRGPQLIEGI-GGRVSQIECASYHT 298



 Score = 77.8 bits (190), Expect = 1e-14
 Identities = 58/186 (31%), Positives = 92/186 (49%), Gaps = 9/186 (4%)
 Frame = +2

Query: 239 WGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGDHSVFLLEDGEVYTCGLNTK 418
           WG  S GQ G+  N +   A PQ    +    + +VA GG HS  L   G  +  G N  
Sbjct: 151 WGRNSEGQLGLGKNSRS-QAIPQKVKSLEGIPLAQVAAGGTHSFALSLTGTSFGWGSNRS 209

Query: 419 GQLGHEREGNK-------PEQIGALADEHIVHVACGESHSLALSDRGQLFSWGAGSDGQL 577
           GQL     GNK       P  IGAL +  +++++CG  H+  L++ GQ+F++G  S GQL
Sbjct: 210 GQLA--LSGNKVKEQIYKPHSIGALKNLSVIYISCGYEHTAVLTEEGQVFTFGGNSSGQL 267

Query: 578 GLMTTEESVAVPRLIQKLNQQTILQVSCGNWHCLA-LAADGQFFTWGKN-SHGQLGLGKE 751
              +       P+LI+ +  + + Q+ C ++H +A +   GQ  + G+  SH      +E
Sbjct: 268 -QPSPRSGQRGPQLIEGIGGR-VSQIECASYHTIAYVYTTGQVVSLGRGPSHTSNPTHQE 325

Query: 752 FPSQAS 769
            P++ S
Sbjct: 326 APAENS 331


>ref|NP_034548.2| E3 ubiquitin-protein ligase HERC2 [Mus musculus].
          Length = 4836

 Score =  164 bits (415), Expect = 1e-40
 Identities = 94/271 (34%), Positives = 140/271 (51%), Gaps = 4/271 (1%)
 Frame = +2

Query: 239  WGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGDHSVFLLEDGEVYTCGLNTK 418
            WG    G+ G  + +     +P++   +  + ++++ACG  HS  L   GE+YT GL   
Sbjct: 3072 WGEGDDGKLGHFSRMN--CDKPRLIEALKTKRIRDIACGSSHSAALTSSGELYTWGLGEY 3129

Query: 419  GQLGHEREGN--KPEQIGALADEHIVHVACG--ESHSLALSDRGQLFSWGAGSDGQLGLM 586
            G+LGH       KP+ +  L    ++ VACG  ++ +LAL+D G +FSWG G  G+LG  
Sbjct: 3130 GRLGHGDNTTQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFSWGDGDFGKLG-R 3188

Query: 587  TTEESVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQA 766
               E   +P+ I++LN Q + Q+ CG    LAL   G  +TWGK  + +LG G +   + 
Sbjct: 3189 GGSEGCNIPQNIERLNGQGVCQIECGAQFSLALTKSGVVWTWGKGDYFRLGHGSDVHVR- 3247

Query: 767  SPQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEEDRESPCHVKLL 946
             PQ V  L G  +  VA G  H  A++ SG V+ WG N+ GQ G         P  V+ L
Sbjct: 3248 KPQVVEGLRGKKIVHVAVGALHCLAVTDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQGL 3307

Query: 947  RAQKVVYISCGEEHTAVLTKVEVCLPLVLVP 1039
              QK+  ++CG  H+   T V+V  P V  P
Sbjct: 3308 EGQKITRVACGSSHSVAWTTVDVATPSVHEP 3338



 Score =  135 bits (339), Expect = 7e-32
 Identities = 93/262 (35%), Positives = 137/262 (52%), Gaps = 9/262 (3%)
 Frame = +2

Query: 248  WSLGQPGISTNLQGI-VAEPQVCGFISDRSVKEVACGGDHSVFLLE-DGEVYTCGLNTKG 421
            W L        L+G  +  P     +S  +V +VA GG  S+F +  +G+VY+CG  T G
Sbjct: 2965 WGLNDKDQLGGLKGSKIKVPSFSETLSALNVVQVA-GGSKSLFAVTVEGKVYSCGEATNG 3023

Query: 422  QLGHEREGNK---PEQIGALADEHIVHVA--CGESHSLALSDRGQLFSWGAGSDGQLGLM 586
            +LG          P QI AL+   +  VA   G  H+ AL+  G++FSWG G DG+LG  
Sbjct: 3024 RLGLGMSSGTVPIPRQITALSSYVVKKVAVHSGGRHATALTVDGKVFSWGEGDDGKLGHF 3083

Query: 587  TTEESVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQA 766
             +  +   PRLI+ L  + I  ++CG+ H  AL + G+ +TWG   +G+LG G +  +Q 
Sbjct: 3084 -SRMNCDKPRLIEALKTKRIRDIACGSSHSAALTSSGELYTWGLGEYGRLGHG-DNTTQL 3141

Query: 767  SPQRVRSLEGIPLAQVAAGG--AHSFALSLSGAVFGWGMNNAGQLGLSDEEDRESPCHVK 940
             P+ V+ L G  + QVA G   A + AL+  G VF WG  + G+LG    E    P +++
Sbjct: 3142 KPKMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFSWGDGDFGKLGRGGSEGCNIPQNIE 3201

Query: 941  LLRAQKVVYISCGEEHTAVLTK 1006
             L  Q V  I CG + +  LTK
Sbjct: 3202 RLNGQGVCQIECGAQFSLALTK 3223



 Score =  131 bits (330), Expect = 8e-31
 Identities = 77/245 (31%), Positives = 135/245 (55%), Gaps = 10/245 (4%)
 Frame = +2

Query: 302  PQVCGFISDRSVKEVACGGD--HSVFLLEDGEVYTCGLNTKGQLGHEREG--NKPEQIGA 469
            PQ+   ++ R++ ++A   D  H + L   GEVY+ G    G+LGH       +P+ I A
Sbjct: 485  PQLVQGLASRNIVKIAAHSDGHHYLALAATGEVYSWGCGDGGRLGHGDTVPLEEPKVISA 544

Query: 470  L----ADEHIVHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTEESVAVPRLIQKLNQ 637
                 A +H+VH+ACG ++S A++  G+L++WG G+ G+LG  ++E+  A+P L+  L  
Sbjct: 545  FSGKQAGKHVVHIACGSTYSAAITAEGELYTWGRGNYGRLGHGSSEDE-AIPMLVAGLKG 603

Query: 638  QTILQVSCGNW--HCLALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQ 811
              ++ V+CG+     LA+  +GQ ++WG   +G+LG G       +P+ +  L+ + + +
Sbjct: 604  LKVIDVACGSGDAQTLAVTENGQVWSWGDGDYGKLGRGGS-DGCKTPKLIEKLQDLDVIK 662

Query: 812  VAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEEDRESPCHVKLLRAQKVVYISCGEEHT 991
            V  G   S AL+  G V+ WG  +  +LG   EE    P  ++ L+ +KV+ ++ G  H 
Sbjct: 663  VRCGSQFSIALTKDGQVYSWGKGDNQRLGHGTEEHVRYPKLLEGLQGKKVIDVAAGSTHC 722

Query: 992  AVLTK 1006
              LT+
Sbjct: 723  LALTE 727



 Score =  129 bits (325), Expect = 3e-30
 Identities = 76/234 (32%), Positives = 120/234 (51%), Gaps = 4/234 (1%)
 Frame = +2

Query: 302  PQVCGFISDRSVKEVACGGDHSVFLLEDGEVYTCGLNTKGQLGHEREGN--KPEQIGALA 475
            P+V   +    V +VA GG HS  +   G++YT G    G+LGH    +  KP+ + AL 
Sbjct: 4084 PRVIESLRGIEVVDVAAGGAHSACVTAAGDLYTWGKGRYGRLGHSDSEDQLKPKLVEALQ 4143

Query: 476  DEHIVHVACG--ESHSLALSDRGQLFSWGAGSDGQLGLMTTEESVAVPRLIQKLNQQTIL 649
               ++ +ACG  ++ +L L+D   ++SWG G  G+LG     +   VP  I  L    ++
Sbjct: 4144 GHRVIDIACGSGDAQTLCLTDDDTVWSWGDGDYGKLG-RGGSDGCKVPMKIDSLTGLGVV 4202

Query: 650  QVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGA 829
            +V CG+   +AL   G  +TWGK  + +LG G +      P++V+ L+G  +  +A G  
Sbjct: 4203 KVECGSQFSVALTKSGAVYTWGKGDYHRLGHGSD-DHVRRPRQVQGLQGKKVIAIATGSL 4261

Query: 830  HSFALSLSGAVFGWGMNNAGQLGLSDEEDRESPCHVKLLRAQKVVYISCGEEHT 991
            H    +  G V+ WG N+ GQLG       + P  V  L+ +KV  ++CG  HT
Sbjct: 4262 HCVCCTEDGEVYTWGDNDEGQLGDGTTNAIQRPRLVAALQGKKVNRVACGSAHT 4315



 Score =  127 bits (320), Expect = 1e-29
 Identities = 78/203 (38%), Positives = 118/203 (58%), Gaps = 5/203 (2%)
 Frame = +2

Query: 386  GEVYTCGLNTKGQLGHEREGNK---PEQIGALADEHIVHVACGESHSLALSDRGQLFSWG 556
            G +Y  G N +GQLG   EG K   P    ALA    V +  GE    A++  G+L++ G
Sbjct: 3954 GTIYGWGHNHRGQLGGI-EGAKVKVPTPCEALATLRPVQLIGGEQTLFAVTADGKLYATG 4012

Query: 557  AGSDGQLGLMTTEESVAVPRLIQKLNQQTI--LQVSCGNWHCLALAADGQFFTWGKNSHG 730
             G+ G+LG+  TE SV+ P L++ +    I  + V+ G  HCLAL+++G+ ++WG+   G
Sbjct: 4013 YGAGGRLGIGGTE-SVSTPTLLESIQHVFIKKVAVNSGGKHCLALSSEGEVYSWGEAEDG 4071

Query: 731  QLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDE 910
            +LG G   P    P+ + SL GI +  VAAGGAHS  ++ +G ++ WG    G+LG SD 
Sbjct: 4072 KLGHGNRSPCDR-PRVIESLRGIEVVDVAAGGAHSACVTAAGDLYTWGKGRYGRLGHSDS 4130

Query: 911  EDRESPCHVKLLRAQKVVYISCG 979
            ED+  P  V+ L+  +V+ I+CG
Sbjct: 4131 EDQLKPKLVEALQGHRVIDIACG 4153



 Score =  127 bits (319), Expect = 1e-29
 Identities = 82/261 (31%), Positives = 135/261 (51%), Gaps = 6/261 (2%)
 Frame = +2

Query: 242  GYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVAC--GGDHSVFLLEDGEVYTCGLNT 415
            GY + G+ GI       V+ P +   I    +K+VA   GG H + L  +GEVY+ G   
Sbjct: 4012 GYGAGGRLGIGGTES--VSTPTLLESIQHVFIKKVAVNSGGKHCLALSSEGEVYSWGEAE 4069

Query: 416  KGQLGHEREG--NKPEQIGALADEHIVHVACGESHSLALSDRGQLFSWGAGSDGQLGLMT 589
             G+LGH      ++P  I +L    +V VA G +HS  ++  G L++WG G  G+LG   
Sbjct: 4070 DGKLGHGNRSPCDRPRVIESLRGIEVVDVAAGGAHSACVTAAGDLYTWGKGRYGRLGHSD 4129

Query: 590  TEESVAVPRLIQKLNQQTILQVSCGNWHC--LALAADGQFFTWGKNSHGQLGLGKEFPSQ 763
            +E+ +  P+L++ L    ++ ++CG+     L L  D   ++WG   +G+LG G     +
Sbjct: 4130 SEDQLK-PKLVEALQGHRVIDIACGSGDAQTLCLTDDDTVWSWGDGDYGKLGRGGSDGCK 4188

Query: 764  ASPQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEEDRESPCHVKL 943
              P ++ SL G+ + +V  G   S AL+ SGAV+ WG  +  +LG   ++    P  V+ 
Sbjct: 4189 V-PMKIDSLTGLGVVKVECGSQFSVALTKSGAVYTWGKGDYHRLGHGSDDHVRRPRQVQG 4247

Query: 944  LRAQKVVYISCGEEHTAVLTK 1006
            L+ +KV+ I+ G  H    T+
Sbjct: 4248 LQGKKVIAIATGSLHCVCCTE 4268



 Score =  127 bits (318), Expect = 2e-29
 Identities = 81/261 (31%), Positives = 132/261 (50%), Gaps = 8/261 (3%)
 Frame = +2

Query: 221  TQTMLCWGYWSLGQPGISTNLQGIVAEPQVCGFISDRS----VKEVACGGDHSVFLLEDG 388
            T  +  WG    G+ G    +   + EP+V    S +     V  +ACG  +S  +  +G
Sbjct: 514  TGEVYSWGCGDGGRLGHGDTVP--LEEPKVISAFSGKQAGKHVVHIACGSTYSAAITAEG 571

Query: 389  EVYTCGLNTKGQLGHEREGNK--PEQIGALADEHIVHVACG--ESHSLALSDRGQLFSWG 556
            E+YT G    G+LGH    ++  P  +  L    ++ VACG  ++ +LA+++ GQ++SWG
Sbjct: 572  ELYTWGRGNYGRLGHGSSEDEAIPMLVAGLKGLKVIDVACGSGDAQTLAVTENGQVWSWG 631

Query: 557  AGSDGQLGLMTTEESVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQL 736
             G  G+LG     +    P+LI+KL    +++V CG+   +AL  DGQ ++WGK  + +L
Sbjct: 632  DGDYGKLG-RGGSDGCKTPKLIEKLQDLDVIKVRCGSQFSIALTKDGQVYSWGKGDNQRL 690

Query: 737  GLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEED 916
            G G E      P+ +  L+G  +  VAAG  H  AL+    V  WG N+  Q   +    
Sbjct: 691  GHGTE-EHVRYPKLLEGLQGKKVIDVAAGSTHCLALTEDSEVHSWGSNDQCQHFDTLRVT 749

Query: 917  RESPCHVKLLRAQKVVYISCG 979
            +  P  +  L ++ +V I+CG
Sbjct: 750  KPEPTALPGLDSKHIVGIACG 770



 Score =  117 bits (293), Expect = 2e-26
 Identities = 71/245 (28%), Positives = 126/245 (51%), Gaps = 7/245 (2%)
 Frame = +2

Query: 293  VAEPQVCGFISDRSVKEVACGGDHSVFLLEDGEVYTCGLNTKGQLGHEREGNKPEQIGAL 472
            V  P  C  ++   V +VAC     + L  +G VYT   N+        +   P+ +  L
Sbjct: 440  VIGPIQCEGLASLGVMQVACAEKRFLILSRNGRVYTQAYNS--------DMLAPQLVQGL 491

Query: 473  ADEHIVHVACGES--HSLALSDRGQLFSWGAGSDGQLG---LMTTEESVAVPRLIQKLNQ 637
            A  +IV +A      H LAL+  G+++SWG G  G+LG    +  EE   +     K   
Sbjct: 492  ASRNIVKIAAHSDGHHYLALAATGEVYSWGCGDGGRLGHGDTVPLEEPKVISAFSGKQAG 551

Query: 638  QTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVA 817
            + ++ ++CG+ +  A+ A+G+ +TWG+ ++G+LG G     +A P  V  L+G+ +  VA
Sbjct: 552  KHVVHIACGSTYSAAITAEGELYTWGRGNYGRLGHGSS-EDEAIPMLVAGLKGLKVIDVA 610

Query: 818  --AGGAHSFALSLSGAVFGWGMNNAGQLGLSDEEDRESPCHVKLLRAQKVVYISCGEEHT 991
              +G A + A++ +G V+ WG  + G+LG    +  ++P  ++ L+   V+ + CG + +
Sbjct: 611  CGSGDAQTLAVTENGQVWSWGDGDYGKLGRGGSDGCKTPKLIEKLQDLDVIKVRCGSQFS 670

Query: 992  AVLTK 1006
              LTK
Sbjct: 671  IALTK 675



 Score =  108 bits (271), Expect = 5e-24
 Identities = 66/209 (31%), Positives = 110/209 (52%), Gaps = 5/209 (2%)
 Frame = +2

Query: 389  EVYTCGLNTKGQLGHEREGNK---PEQIGALADEHIVHVACGESHSLALSDRGQLFSWGA 559
            +V+  GLN K QLG  + G+K   P     L+  ++V VA G     A++  G+++S G 
Sbjct: 2961 KVFVWGLNDKDQLGGLK-GSKIKVPSFSETLSALNVVQVAGGSKSLFAVTVEGKVYSCGE 3019

Query: 560  GSDGQLGLMTTEESVAVPRLIQKLNQQTILQVS--CGNWHCLALAADGQFFTWGKNSHGQ 733
             ++G+LGL  +  +V +PR I  L+   + +V+   G  H  AL  DG+ F+WG+   G+
Sbjct: 3020 ATNGRLGLGMSSGTVPIPRQITALSSYVVKKVAVHSGGRHATALTVDGKVFSWGEGDDGK 3079

Query: 734  LGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEE 913
            LG          P+ + +L+   +  +A G +HS AL+ SG ++ WG+   G+LG  D  
Sbjct: 3080 LGHFSRMNCD-KPRLIEALKTKRIRDIACGSSHSAALTSSGELYTWGLGEYGRLGHGDNT 3138

Query: 914  DRESPCHVKLLRAQKVVYISCGEEHTAVL 1000
             +  P  VK+L   +V+ ++CG      L
Sbjct: 3139 TQLKPKMVKVLLGHRVIQVACGSRDAQTL 3167



 Score =  103 bits (256), Expect = 3e-22
 Identities = 69/209 (33%), Positives = 113/209 (54%), Gaps = 4/209 (1%)
 Frame = +2

Query: 239  WGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACG-GD-HSVFLLEDGEVYTCGLN 412
            WG    G+ G S +   +  +P++   +    V ++ACG GD  ++ L +D  V++ G  
Sbjct: 4117 WGKGRYGRLGHSDSEDQL--KPKLVEALQGHRVIDIACGSGDAQTLCLTDDDTVWSWGDG 4174

Query: 413  TKGQLGHE-REGNK-PEQIGALADEHIVHVACGESHSLALSDRGQLFSWGAGSDGQLGLM 586
              G+LG    +G K P +I +L    +V V CG   S+AL+  G +++WG G   +LG  
Sbjct: 4175 DYGKLGRGGSDGCKVPMKIDSLTGLGVVKVECGSQFSVALTKSGAVYTWGKGDYHRLG-H 4233

Query: 587  TTEESVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQA 766
             +++ V  PR +Q L  + ++ ++ G+ HC+    DG+ +TWG N  GQLG G     Q 
Sbjct: 4234 GSDDHVRRPRQVQGLQGKKVIAIATGSLHCVCCTEDGEVYTWGDNDEGQLGDGTTNAIQR 4293

Query: 767  SPQRVRSLEGIPLAQVAAGGAHSFALSLS 853
             P+ V +L+G  + +VA G AH+ A S S
Sbjct: 4294 -PRLVAALQGKKVNRVACGSAHTLAWSTS 4321



 Score = 98.2 bits (243), Expect = 9e-21
 Identities = 67/207 (32%), Positives = 109/207 (52%), Gaps = 4/207 (1%)
 Frame = +2

Query: 239  WGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACG-GD-HSVFLLEDGEVYTCGLN 412
            WG  + G+ G  ++    +  P +   +    V +VACG GD  ++ + E+G+V++ G  
Sbjct: 576  WGRGNYGRLGHGSSEDEAI--PMLVAGLKGLKVIDVACGSGDAQTLAVTENGQVWSWGDG 633

Query: 413  TKGQLGHE-REGNK-PEQIGALADEHIVHVACGESHSLALSDRGQLFSWGAGSDGQLGLM 586
              G+LG    +G K P+ I  L D  ++ V CG   S+AL+  GQ++SWG G + +LG  
Sbjct: 634  DYGKLGRGGSDGCKTPKLIEKLQDLDVIKVRCGSQFSIALTKDGQVYSWGKGDNQRLG-H 692

Query: 587  TTEESVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQA 766
             TEE V  P+L++ L  + ++ V+ G+ HCLAL  D +  +WG N   Q        ++ 
Sbjct: 693  GTEEHVRYPKLLEGLQGKKVIDVAAGSTHCLALTEDSEVHSWGSNDQCQ-HFDTLRVTKP 751

Query: 767  SPQRVRSLEGIPLAQVAAGGAHSFALS 847
             P  +  L+   +  +A G A SFA S
Sbjct: 752  EPTALPGLDSKHIVGIACGPAQSFAWS 778



 Score = 88.6 bits (218), Expect = 7e-18
 Identities = 57/193 (29%), Positives = 92/193 (47%), Gaps = 6/193 (3%)
 Frame = +2

Query: 452  PEQIGALADEHIVHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTEESVAVPRLIQKL 631
            P Q   LA   ++ VAC E   L LS  G++++    SD           +  P+L+Q L
Sbjct: 443  PIQCEGLASLGVMQVACAEKRFLILSRNGRVYTQAYNSD-----------MLAPQLVQGL 491

Query: 632  NQQTILQVSCGN--WHCLALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIP- 802
              + I++++  +   H LALAA G+ ++WG    G+LG G   P +  P+ + +  G   
Sbjct: 492  ASRNIVKIAAHSDGHHYLALAATGEVYSWGCGDGGRLGHGDTVPLE-EPKVISAFSGKQA 550

Query: 803  ---LAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEEDRESPCHVKLLRAQKVVYIS 973
               +  +A G  +S A++  G ++ WG  N G+LG    ED   P  V  L+  KV+ ++
Sbjct: 551  GKHVVHIACGSTYSAAITAEGELYTWGRGNYGRLGHGSSEDEAIPMLVAGLKGLKVIDVA 610

Query: 974  CGEEHTAVLTKVE 1012
            CG      L   E
Sbjct: 611  CGSGDAQTLAVTE 623



 Score = 88.2 bits (217), Expect = 1e-17
 Identities = 47/159 (29%), Positives = 90/159 (56%), Gaps = 2/159 (1%)
 Frame = +2

Query: 533  RGQLFSWGAGSDGQLGLMTTEESVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTW 712
            R ++F WG     QLG +   + + VP   + L+   ++QV+ G+    A+  +G+ ++ 
Sbjct: 2959 RTKVFVWGLNDKDQLGGLKGSK-IKVPSFSETLSALNVVQVAGGSKSLFAVTVEGKVYSC 3017

Query: 713  GKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVA--AGGAHSFALSLSGAVFGWGMNNA 886
            G+ ++G+LGLG    +   P+++ +L    + +VA  +GG H+ AL++ G VF WG  + 
Sbjct: 3018 GEATNGRLGLGMSSGTVPIPRQITALSSYVVKKVAVHSGGRHATALTVDGKVFSWGEGDD 3077

Query: 887  GQLGLSDEEDRESPCHVKLLRAQKVVYISCGEEHTAVLT 1003
            G+LG     + + P  ++ L+ +++  I+CG  H+A LT
Sbjct: 3078 GKLGHFSRMNCDKPRLIEALKTKRIRDIACGSSHSAALT 3116



 Score = 79.7 bits (195), Expect = 3e-15
 Identities = 58/206 (28%), Positives = 95/206 (46%), Gaps = 5/206 (2%)
 Frame = +2

Query: 203  CMTP*RTQTMLCWG---YWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGDHSVF 373
            C+T     T+  WG   Y  LG+ G           P     ++   V +V CG   SV 
Sbjct: 4161 CLTD--DDTVWSWGDGDYGKLGRGGSDG-----CKVPMKIDSLTGLGVVKVECGSQFSVA 4213

Query: 374  LLEDGEVYTCGLNTKGQLGHEREGN--KPEQIGALADEHIVHVACGESHSLALSDRGQLF 547
            L + G VYT G     +LGH  + +  +P Q+  L  + ++ +A G  H +  ++ G+++
Sbjct: 4214 LTKSGAVYTWGKGDYHRLGHGSDDHVRRPRQVQGLQGKKVIAIATGSLHCVCCTEDGEVY 4273

Query: 548  SWGAGSDGQLGLMTTEESVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSH 727
            +WG   +GQLG  TT  ++  PRL+  L  + + +V+CG+ H LA         W  +  
Sbjct: 4274 TWGDNDEGQLGDGTTN-AIQRPRLVAALQGKKVNRVACGSAHTLA---------WSTSKP 4323

Query: 728  GQLGLGKEFPSQASPQRVRSLEGIPL 805
               G   + P+Q  P     L+ IP+
Sbjct: 4324 ASAG---KLPAQV-PMEYNHLQEIPI 4345


>ref|NP_001164165.1| RCC1 and BTB domain-containing protein 2 [Mus musculus].
          Length = 551

 Score =  142 bits (358), Expect = 4e-34
 Identities = 77/236 (32%), Positives = 130/236 (55%), Gaps = 4/236 (1%)
 Frame = +2

Query: 299 EPQVCGFISDRSVKEVACG-GDHSVFLLEDGEVYTCGLNTKGQLGH--EREGNKPEQIGA 469
           EP+    ++ + +  ++ G G H V    DGEV+T G N   QLG+     G  P  I  
Sbjct: 88  EPRRLDSLTGKKIASLSYGSGPHIVLATTDGEVFTWGHNAYSQLGNGTTNHGLVPCHIST 147

Query: 470 -LADEHIVHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTEESVAVPRLIQKLNQQTI 646
            L+++ ++ VACG  HSL L+  G++F+WG  + GQ+G  +T       R+   L  + +
Sbjct: 148 NLSNKQVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTANQPIPRRVTGCLQNKVV 207

Query: 647 LQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGG 826
           + ++CG    +A+   G+ + WG N +GQLGLG    +Q +P RV +L+GI + +VA G 
Sbjct: 208 MNIACGQMCSMAVVDTGEVYVWGYNGNGQLGLGSS-GNQPTPCRVAALQGIRVQRVACGY 266

Query: 827 AHSFALSLSGAVFGWGMNNAGQLGLSDEEDRESPCHVKLLRAQKVVYISCGEEHTA 994
           AH+  L+  G ++ WG N+ GQLG  ++ ++  P  V + + + +   +C   HT+
Sbjct: 267 AHTLVLTDEGQIYAWGANSYGQLGTGNKSNQSYPTPVVVEKDRIIEIAACHSAHTS 322



 Score =  123 bits (309), Expect = 2e-28
 Identities = 69/220 (31%), Positives = 118/220 (53%), Gaps = 4/220 (1%)
 Frame = +2

Query: 356  GDHSVFLLEDGEVYTCGLNTKGQLG--HEREGNKPEQIGALADEHIVHVACGES-HSLAL 526
            G+  ++   + E++  G N  G LG    +   +P ++ +L  + I  ++ G   H +  
Sbjct: 55   GNEVLYTTVNDEIFVLGTNCSGCLGVGDIQSTIEPRRLDSLTGKKIASLSYGSGPHIVLA 114

Query: 527  SDRGQLFSWGAGSDGQLGLMTTEESVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFF 706
            +  G++F+WG  +  QLG  TT   +    +   L+ + +++V+CG++H L L +DG+ F
Sbjct: 115  TTDGEVFTWGHNAYSQLGNGTTNHGLVPCHISTNLSNKQVIEVACGSYHSLVLTSDGEVF 174

Query: 707  TWGKNSHGQLGLGKEFPSQASPQRVRS-LEGIPLAQVAAGGAHSFALSLSGAVFGWGMNN 883
             WG N+ GQ+G G    +Q  P+RV   L+   +  +A G   S A+  +G V+ WG N 
Sbjct: 175  AWGYNNSGQVGSGST-ANQPIPRRVTGCLQNKVVMNIACGQMCSMAVVDTGEVYVWGYNG 233

Query: 884  AGQLGLSDEEDRESPCHVKLLRAQKVVYISCGEEHTAVLT 1003
             GQLGL    ++ +PC V  L+  +V  ++CG  HT VLT
Sbjct: 234  NGQLGLGSSGNQPTPCRVAALQGIRVQRVACGYAHTLVLT 273


>ref|NP_598844.3| RCC1 and BTB domain-containing protein 2 [Mus musculus].
          Length = 551

 Score =  142 bits (358), Expect = 4e-34
 Identities = 77/236 (32%), Positives = 130/236 (55%), Gaps = 4/236 (1%)
 Frame = +2

Query: 299 EPQVCGFISDRSVKEVACG-GDHSVFLLEDGEVYTCGLNTKGQLGH--EREGNKPEQIGA 469
           EP+    ++ + +  ++ G G H V    DGEV+T G N   QLG+     G  P  I  
Sbjct: 88  EPRRLDSLTGKKIASLSYGSGPHIVLATTDGEVFTWGHNAYSQLGNGTTNHGLVPCHIST 147

Query: 470 -LADEHIVHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTEESVAVPRLIQKLNQQTI 646
            L+++ ++ VACG  HSL L+  G++F+WG  + GQ+G  +T       R+   L  + +
Sbjct: 148 NLSNKQVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTANQPIPRRVTGCLQNKVV 207

Query: 647 LQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGG 826
           + ++CG    +A+   G+ + WG N +GQLGLG    +Q +P RV +L+GI + +VA G 
Sbjct: 208 MNIACGQMCSMAVVDTGEVYVWGYNGNGQLGLGSS-GNQPTPCRVAALQGIRVQRVACGY 266

Query: 827 AHSFALSLSGAVFGWGMNNAGQLGLSDEEDRESPCHVKLLRAQKVVYISCGEEHTA 994
           AH+  L+  G ++ WG N+ GQLG  ++ ++  P  V + + + +   +C   HT+
Sbjct: 267 AHTLVLTDEGQIYAWGANSYGQLGTGNKSNQSYPTPVVVEKDRIIEIAACHSAHTS 322



 Score =  123 bits (309), Expect = 2e-28
 Identities = 69/220 (31%), Positives = 118/220 (53%), Gaps = 4/220 (1%)
 Frame = +2

Query: 356  GDHSVFLLEDGEVYTCGLNTKGQLG--HEREGNKPEQIGALADEHIVHVACGES-HSLAL 526
            G+  ++   + E++  G N  G LG    +   +P ++ +L  + I  ++ G   H +  
Sbjct: 55   GNEVLYTTVNDEIFVLGTNCSGCLGVGDIQSTIEPRRLDSLTGKKIASLSYGSGPHIVLA 114

Query: 527  SDRGQLFSWGAGSDGQLGLMTTEESVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFF 706
            +  G++F+WG  +  QLG  TT   +    +   L+ + +++V+CG++H L L +DG+ F
Sbjct: 115  TTDGEVFTWGHNAYSQLGNGTTNHGLVPCHISTNLSNKQVIEVACGSYHSLVLTSDGEVF 174

Query: 707  TWGKNSHGQLGLGKEFPSQASPQRVRS-LEGIPLAQVAAGGAHSFALSLSGAVFGWGMNN 883
             WG N+ GQ+G G    +Q  P+RV   L+   +  +A G   S A+  +G V+ WG N 
Sbjct: 175  AWGYNNSGQVGSGST-ANQPIPRRVTGCLQNKVVMNIACGQMCSMAVVDTGEVYVWGYNG 233

Query: 884  AGQLGLSDEEDRESPCHVKLLRAQKVVYISCGEEHTAVLT 1003
             GQLGL    ++ +PC V  L+  +V  ++CG  HT VLT
Sbjct: 234  NGQLGLGSSGNQPTPCRVAALQGIRVQRVACGYAHTLVLT 273


>ref|NP_082040.2| RCC1 and BTB domain-containing protein 1 [Mus musculus].
          Length = 531

 Score =  137 bits (345), Expect = 1e-32
 Identities = 76/233 (32%), Positives = 127/233 (54%), Gaps = 4/233 (1%)
 Frame = +2

Query: 308 VCGFISDRSVKEVACG-GDHSVFLLEDGEVYTCGLNTKGQLGH--EREGNKPEQIGA-LA 475
           +CG    + +K ++ G G H +   EDG VY  G N   QLG+    +G  P Q+   L 
Sbjct: 71  LCG----KKIKSLSYGSGPHVLLTTEDGVVYAWGHNGYSQLGNGTTNQGIAPVQVCTNLL 126

Query: 476 DEHIVHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTEESVAVPRLIQKLNQQTILQV 655
            + ++ VACG  HS+AL+  G+LF+WG  + GQ+G  +T       ++   L+ + ++ +
Sbjct: 127 IKQVIEVACGSHHSMALAADGELFAWGYNNCGQVGSGSTANQPTPRKVTNCLHTKRVVNI 186

Query: 656 SCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHS 835
           +CG    +A+   G+ + WG N +GQLGLG    +Q +P RV +L G+ + Q+  G AH+
Sbjct: 187 ACGQTSSMAVLDSGEVYGWGYNGNGQLGLGNN-GNQLTPVRVAALHGMCVNQIVCGYAHT 245

Query: 836 FALSLSGAVFGWGMNNAGQLGLSDEEDRESPCHVKLLRAQKVVYISCGEEHTA 994
            AL+  G ++ WG N  GQLG   + +  SP  + + + + +   +C   HT+
Sbjct: 246 LALTDEGLLYAWGANTYGQLGTGSKNNLLSPTQIMVEKERVIEIAACHSTHTS 298



 Score =  125 bits (314), Expect = 6e-29
 Identities = 78/238 (32%), Positives = 125/238 (52%), Gaps = 4/238 (1%)
 Frame = +2

Query: 302  PQVCGFISDRSVKEVACGGDHSVFLLEDGEVYTCGLNTKGQLG--HEREGNKPEQIGALA 475
            PQ  G I    V       + ++++ ++ EV+  GLN    LG    +    P+++ AL 
Sbjct: 15   PQEAGSIRKACV--FGTSANEAIYVTDNDEVFVFGLNYSNCLGTGDNQSTLVPKKLEALC 72

Query: 476  DEHIVHVACGES-HSLALSDRGQLFSWGAGSDGQLGLMTTEESVAVPRLIQKLNQQTILQ 652
             + I  ++ G   H L  ++ G +++WG     QLG  TT + +A  ++   L  + +++
Sbjct: 73   GKKIKSLSYGSGPHVLLTTEDGVVYAWGHNGYSQLGNGTTNQGIAPVQVCTNLLIKQVIE 132

Query: 653  VSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRS-LEGIPLAQVAAGGA 829
            V+CG+ H +ALAADG+ F WG N+ GQ+G G    +Q +P++V + L    +  +A G  
Sbjct: 133  VACGSHHSMALAADGELFAWGYNNCGQVGSGST-ANQPTPRKVTNCLHTKRVVNIACGQT 191

Query: 830  HSFALSLSGAVFGWGMNNAGQLGLSDEEDRESPCHVKLLRAQKVVYISCGEEHTAVLT 1003
             S A+  SG V+GWG N  GQLGL +  ++ +P  V  L    V  I CG  HT  LT
Sbjct: 192  SSMAVLDSGEVYGWGYNGNGQLGLGNNGNQLTPVRVAALHGMCVNQIVCGYAHTLALT 249



 Score =  124 bits (311), Expect = 1e-28
 Identities = 77/220 (35%), Positives = 114/220 (51%), Gaps = 8/220 (3%)
 Frame = +2

Query: 239 WGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGDHSVFLLEDGEVYTCGLNTK 418
           WG+    Q G  T  QGI A  QVC  +  + V EVACG  HS+ L  DGE++  G N  
Sbjct: 99  WGHNGYSQLGNGTTNQGI-APVQVCTNLLIKQVIEVACGSHHSMALAADGELFAWGYNNC 157

Query: 419 GQLGHEREGNKP---EQIGALADEHIVHVACGESHSLALSDRGQLFSWGAGSDGQLGLMT 589
           GQ+G     N+P   +    L  + +V++ACG++ S+A+ D G+++ WG   +GQLGL  
Sbjct: 158 GQVGSGSTANQPTPRKVTNCLHTKRVVNIACGQTSSMAVLDSGEVYGWGYNGNGQLGLGN 217

Query: 590 TEESVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKE----FP 757
               +  P  +  L+   + Q+ CG  H LAL  +G  + WG N++GQLG G +     P
Sbjct: 218 NGNQL-TPVRVAALHGMCVNQIVCGYAHTLALTDEGLLYAWGANTYGQLGTGSKNNLLSP 276

Query: 758 SQASPQRVRSLEGIPLAQVAAGGAH-SFALSLSGAVFGWG 874
           +Q   ++ R +E       A    H S A +  G V+ WG
Sbjct: 277 TQIMVEKERVIE-----IAACHSTHTSAAKTQGGHVYMWG 311


>ref|NP_663592.3| hect domain and RCC1-like domain 1 [Mus musculus].
          Length = 4859

 Score =  129 bits (324), Expect = 4e-30
 Identities = 96/308 (31%), Positives = 140/308 (45%), Gaps = 55/308 (17%)
 Frame = +2

Query: 245  YWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGD-HSVFLLEDGEVYTCGLNTKG 421
            Y  LGQ G S +L  +     + GF+  + V   +CG D HS+ L E GEV++ G    G
Sbjct: 4054 YGRLGQ-GNSDDLHVLTVISALQGFVVTQLV--TSCGSDGHSMALTESGEVFSWGDGDYG 4110

Query: 422  QLGHEREGN--KPEQIGALADEHIVHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTE 595
            +LGH       +P QI AL  E +V ++CG  HS  ++  G+LF++G G  G+LGL  T 
Sbjct: 4111 KLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLGLGNTS 4170

Query: 596  ESVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQF-FTWGKNSHGQLGLG----KEFPS 760
                +P  +  L    I QV+CG  H LA++ADG   + +G   +G+LGLG    K  P 
Sbjct: 4171 NK-KLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNSTAKSSPQ 4229

Query: 761  QAS-----------------------------------------------PQRVRSLEGI 799
            +                                                 PQ++  L G+
Sbjct: 4230 KVDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGLPEGRARNHNRPQQIPVLAGV 4289

Query: 800  PLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEEDRESPCHVKLLRAQKVVYISCG 979
             +  VA G  H+ AL+ +G V+ WG N+ GQLGL        P  V +L+ + +  IS G
Sbjct: 4290 VIEDVAVGAEHTLALASTGDVYAWGSNSEGQLGLGHTNHVREPTLVTVLQGKNIRQISAG 4349

Query: 980  EEHTAVLT 1003
              H+A  T
Sbjct: 4350 RCHSAAWT 4357



 Score =  127 bits (318), Expect = 2e-29
 Identities = 84/262 (32%), Positives = 138/262 (52%), Gaps = 9/262 (3%)
 Frame = +2

Query: 248  WSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGDHSVFLLEDGEVYTCGLNTKGQL 427
            W  G+ G        V  P      S    ++V CG + +  +  +G V  CG  + G+L
Sbjct: 4000 WGAGRHGQLAEAGRNVMVPATAPSFSQ--AQQVICGQNCTFVIQANGTVLACGEGSYGRL 4057

Query: 428  GHEREGNKPEQ-----IGALADEHIVHV--ACG-ESHSLALSDRGQLFSWGAGSDGQLGL 583
            G   +GN  +      I AL    +  +  +CG + HS+AL++ G++FSWG G  G+LG 
Sbjct: 4058 G---QGNSDDLHVLTVISALQGFVVTQLVTSCGSDGHSMALTESGEVFSWGDGDYGKLGH 4114

Query: 584  MTTEESVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQ 763
              ++     PR I+ L  + ++Q+SCG  H   + +DG+ FT+G   +G+LGLG    ++
Sbjct: 4115 GNSDRQRR-PRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLGLGNT-SNK 4172

Query: 764  ASPQRVRSLEGIPLAQVAAGGAHSFALSLSGA-VFGWGMNNAGQLGLSDEEDRESPCHVK 940
              P+RV +LEG  + QVA G  H+ A+S  G+ V+ +G  + G+LGL +   + SP  V 
Sbjct: 4173 KLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNSTAKSSPQKVD 4232

Query: 941  LLRAQKVVYISCGEEHTAVLTK 1006
            +L    +  ++CG + +  LTK
Sbjct: 4233 VLCGIGIKKVACGTQFSVALTK 4254



 Score =  119 bits (297), Expect = 5e-27
 Identities = 66/173 (38%), Positives = 100/173 (57%), Gaps = 3/173 (1%)
 Frame = +2

Query: 332  SVKEVACGGDHSVFLLEDGE-VYTCGLNTKGQLGHEREGN--KPEQIGALADEHIVHVAC 502
            +V EV+CG  H++ L +DG  V++ G    G+LGH       KP+ I AL    I  V  
Sbjct: 562  NVGEVSCGSSHTIALSKDGRTVWSFGGGDNGKLGHGDTNRVYKPKVIEALQGMFIRKVCA 621

Query: 503  GESHSLALSDRGQLFSWGAGSDGQLGLMTTEESVAVPRLIQKLNQQTILQVSCGNWHCLA 682
            G   SLAL+  GQ+++WG G+   LG  ++E +   P+LI++L    I+ +S G+ HCL+
Sbjct: 622  GSQSSLALTSTGQVYAWGCGAC--LGCGSSEATALRPKLIEELAATRIVDISIGDSHCLS 679

Query: 683  LAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFA 841
            L+ D + + WG NS GQ G G        P++V  L+GI + Q++AG +HS A
Sbjct: 680  LSHDNEVYAWGNNSMGQCGQGNSTGPITKPKKVSGLDGIAIQQISAGTSHSLA 732



 Score =  108 bits (269), Expect = 9e-24
 Identities = 81/262 (30%), Positives = 139/262 (53%), Gaps = 7/262 (2%)
 Frame = +2

Query: 239  WGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVAC--GGD-HSVFLLEDGEVYTCGL 409
            +G   LG     + L+ +  EP        RS+K+V+   G D H++    +GEV++ G 
Sbjct: 432  YGRLGLGDSNNQSTLKKLTFEPH-------RSIKKVSSSKGSDGHTLAFTTEGEVFSWGD 484

Query: 410  NTKGQLGHEREGNK--PEQI-GALADEHIVHVACGESHSLALSDRGQLFSWGAGSDGQLG 580
               G+LGH     +  P+ I G L  + +V V+ G  HS A+++ G+L++WG G  G+LG
Sbjct: 485  GDYGKLGHGNSSTQKYPKLIQGPLQGKVVVCVSAGYRHSAAVTEDGELYTWGEGDFGRLG 544

Query: 581  LMTTEESVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQ-FFTWGKNSHGQLGLGKEFP 757
                  S  +P L++ ++   + +VSCG+ H +AL+ DG+  +++G   +G+LG G +  
Sbjct: 545  -HGDSNSRNIPTLVKDIS--NVGEVSCGSSHTIALSKDGRTVWSFGGGDNGKLGHG-DTN 600

Query: 758  SQASPQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEEDRESPCHV 937
                P+ + +L+G+ + +V AG   S AL+ +G V+ WG       G S E     P  +
Sbjct: 601  RVYKPKVIEALQGMFIRKVCAGSQSSLALTSTGQVYAWGCGACLGCG-SSEATALRPKLI 659

Query: 938  KLLRAQKVVYISCGEEHTAVLT 1003
            + L A ++V IS G+ H   L+
Sbjct: 660  EELAATRIVDISIGDSHCLSLS 681



 Score = 91.3 bits (225), Expect = 1e-18
 Identities = 59/210 (28%), Positives = 106/210 (50%), Gaps = 5/210 (2%)
 Frame = +2

Query: 389  EVYTCGLNTKGQLGHEREGNKPEQIGALADE--HIVHVACGESHSLALSDRGQLFSWGAG 562
            +VY  G    GQL    E  +   + A A        V CG++ +  +   G + + G G
Sbjct: 3996 DVYLWGAGRHGQLA---EAGRNVMVPATAPSFSQAQQVICGQNCTFVIQANGTVLACGEG 4052

Query: 563  SDGQLGLMTTEESVAVPRLIQKLNQQTILQV--SCGN-WHCLALAADGQFFTWGKNSHGQ 733
            S G+LG   +++ + V  +I  L    + Q+  SCG+  H +AL   G+ F+WG   +G+
Sbjct: 4053 SYGRLGQGNSDD-LHVLTVISALQGFVVTQLVTSCGSDGHSMALTESGEVFSWGDGDYGK 4111

Query: 734  LGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEE 913
            LG G     Q  P+++ +L+G  + Q++ G  HS  ++  G +F +G  + G+LGL +  
Sbjct: 4112 LGHGNS-DRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLGLGNTS 4170

Query: 914  DRESPCHVKLLRAQKVVYISCGEEHTAVLT 1003
            +++ P  V  L   ++  ++CG  HT  ++
Sbjct: 4171 NKKLPERVTALEGYQIGQVACGLNHTLAVS 4200



 Score = 88.2 bits (217), Expect = 1e-17
 Identities = 72/246 (29%), Positives = 119/246 (48%), Gaps = 12/246 (4%)
 Frame = +2

Query: 305  QVCGFISDRSVKEVACGGDHSV------FLLEDGEVYTCGLNTKGQL--GHEREGNKPEQ 460
            +VC   SD S     C    S+       + E  EVY  G N+  QL  G + +  +P+ 
Sbjct: 342  EVCRMASDYSR---TCASPDSIQTGDAPIVSETCEVYVWGSNSSHQLVEGTQEKILQPKL 398

Query: 461  IGALADEHIVHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTEESVAVPRLIQKLNQQ 640
              + +D   +    G+  +  +S  G + + G GS G+LGL  +     + +L  + ++ 
Sbjct: 399  APSFSDAQTIEA--GQYCTFVISTDGSVRACGKGSYGRLGLGDSNNQSTLKKLTFEPHR- 455

Query: 641  TILQVSCG---NWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRS-LEGIPLA 808
            +I +VS     + H LA   +G+ F+WG   +G+LG G    +Q  P+ ++  L+G  + 
Sbjct: 456  SIKKVSSSKGSDGHTLAFTTEGEVFSWGDGDYGKLGHGNS-STQKYPKLIQGPLQGKVVV 514

Query: 809  QVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEEDRESPCHVKLLRAQKVVYISCGEEH 988
             V+AG  HS A++  G ++ WG  + G+LG  D   R  P  VK +    V  +SCG  H
Sbjct: 515  CVSAGYRHSAAVTEDGELYTWGEGDFGRLGHGDSNSRNIPTLVKDI--SNVGEVSCGSSH 572

Query: 989  TAVLTK 1006
            T  L+K
Sbjct: 573  TIALSK 578



 Score = 88.2 bits (217), Expect = 1e-17
 Identities = 54/134 (40%), Positives = 72/134 (53%), Gaps = 2/134 (1%)
 Frame = +2

Query: 296  AEPQVCGFISDRSVKEVACGGDHSVFLLEDGEVYTCGLNTKGQL--GHEREGNKPEQIGA 469
            + PQ    +    +K+VACG   SV L +DG VYT G +    L  G  R  N+P+QI  
Sbjct: 4226 SSPQKVDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGLPEGRARNHNRPQQIPV 4285

Query: 470  LADEHIVHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTEESVAVPRLIQKLNQQTIL 649
            LA   I  VA G  H+LAL+  G +++WG+ S+GQLGL  T   V  P L+  L  + I 
Sbjct: 4286 LAGVVIEDVAVGAEHTLALASTGDVYAWGSNSEGQLGLGHTNH-VREPTLVTVLQGKNIR 4344

Query: 650  QVSCGNWHCLALAA 691
            Q+S G  H  A  A
Sbjct: 4345 QISAGRCHSAAWTA 4358



 Score = 84.0 bits (206), Expect = 2e-16
 Identities = 55/179 (30%), Positives = 86/179 (48%), Gaps = 3/179 (1%)
 Frame = +2

Query: 476  DEHIVHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTEESVAVPRLIQKLNQQTILQV 655
            DE I+  A        L  +  ++ WGAG  GQL       +V VP      +Q    QV
Sbjct: 3975 DEQIMSWATSRPEDWHLGGKCDVYLWGAGRHGQLA--EAGRNVMVPATAPSFSQAQ--QV 4030

Query: 656  SCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAG---G 826
             CG      + A+G     G+ S+G+LG G           + +L+G  + Q+       
Sbjct: 4031 ICGQNCTFVIQANGTVLACGEGSYGRLGQGNSDDLHVLTV-ISALQGFVVTQLVTSCGSD 4089

Query: 827  AHSFALSLSGAVFGWGMNNAGQLGLSDEEDRESPCHVKLLRAQKVVYISCGEEHTAVLT 1003
             HS AL+ SG VF WG  + G+LG  + + +  P  ++ L+ ++VV +SCG +H+AV+T
Sbjct: 4090 GHSMALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVT 4148



 Score = 68.2 bits (165), Expect = 1e-11
 Identities = 44/144 (30%), Positives = 68/144 (47%), Gaps = 4/144 (2%)
 Frame = +2

Query: 293  VAEPQVCGFISDRSVKEVACGGDHSVFLLEDGEVYTCGLNT-KGQLGHEREGNKPEQIGA 469
            V +P+V   +    +++V  G   S+ L   G+VY  G     G    E    +P+ I  
Sbjct: 602  VYKPKVIEALQGMFIRKVCAGSQSSLALTSTGQVYAWGCGACLGCGSSEATALRPKLIEE 661

Query: 470  LADEHIVHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTEESVAVPRLIQKLNQQTIL 649
            LA   IV ++ G+SH L+LS   ++++WG  S GQ G   +   +  P+ +  L+   I 
Sbjct: 662  LAATRIVDISIGDSHCLSLSHDNEVYAWGNNSMGQCGQGNSTGPITKPKKVSGLDGIAIQ 721

Query: 650  QVSCGNWHCL---ALAADGQFFTW 712
            Q+S G  H L   AL  D Q   W
Sbjct: 722  QISAGTSHSLAWTALPRDRQVVAW 745


>ref|NP_001171424.1| X-linked retinitis pigmentosa GTPase regulator isoform 5 [Mus
            musculus].
          Length = 557

 Score =  127 bits (319), Expect = 1e-29
 Identities = 85/264 (32%), Positives = 139/264 (52%), Gaps = 7/264 (2%)
 Frame = +2

Query: 239  WGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGDHSVFLLEDGEVYTCGLNTK 418
            WG   LG        +  + +P     +    VK  ACG +H++   + G VY  G N +
Sbjct: 102  WGQLGLGS-------KAAIIKPTCIKALKPEKVKLAACGRNHTLVSTDTGGVYAAGGNNE 154

Query: 419  GQLGHEREGNKP---EQIGALADEHIVHVACGESHSLALSDRGQLFSWGAGSDGQLGLMT 589
            GQLG     ++    + +     + I  ++ G + S AL++ G+LF WG  S+GQ+GL  
Sbjct: 155  GQLGLGDTDDRDTFHQIVFFTPADTIKQLSAGANTSAALTEDGKLFMWGDNSEGQIGL-E 213

Query: 590  TEESVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKE-FPSQA 766
             + +V +P  +     + I  +SCG +H   +  DG+ +T+G+  +G+LGL  E   +  
Sbjct: 214  DKSNVCIPHEVTV--GKPISWISCGYYHSAFVTMDGELYTFGEPENGKLGLPNELLMNHR 271

Query: 767  SPQRVRSLEGIP--LAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSD-EEDRESPCHV 937
            SPQRV    GIP  + QVA GG H+  L+    V+ +G+   GQLGL     +   P  +
Sbjct: 272  SPQRVL---GIPERVIQVACGGGHTVVLT-EKVVYAFGLGQFGQLGLGTFLFETSEPKII 327

Query: 938  KLLRAQKVVYISCGEEHTAVLTKV 1009
            + ++ QK+ +ISCGE HTA++T++
Sbjct: 328  ERIKDQKICHISCGENHTALMTEL 351



 Score =  116 bits (291), Expect = 3e-26
 Identities = 74/225 (32%), Positives = 122/225 (54%), Gaps = 4/225 (1%)
 Frame = +2

Query: 344  VACGGDHSVFLLEDGEVYTCGLNTKGQLGHEREGN--KPEQIGALADEHIVHVACGESHS 517
            ++CG +H+  +  + ++Y  G N  GQLG   +    KP  I AL  E +   ACG +H+
Sbjct: 78   LSCGDEHTAIVTGNNKLYMFGSNNWGQLGLGSKAAIIKPTCIKALKPEKVKLAACGRNHT 137

Query: 518  LALSDRGQLFSWGAGSDGQLGLMTTEESVAVPRLIQKLNQQTILQVSCGNWHCLALAADG 697
            L  +D G +++ G  ++GQLGL  T++     +++      TI Q+S G     AL  DG
Sbjct: 138  LVSTDTGGVYAAGGNNEGQLGLGDTDDRDTFHQIVFFTPADTIKQLSAGANTSAALTEDG 197

Query: 698  QFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGM 877
            + F WG NS GQ+GL ++  +   P  V    G P++ ++ G  HS  +++ G ++ +G 
Sbjct: 198  KLFMWGDNSEGQIGL-EDKSNVCIPHEV--TVGKPISWISCGYYHSAFVTMDGELYTFGE 254

Query: 878  NNAGQLGLSDE--EDRESPCHVKLLRAQKVVYISCGEEHTAVLTK 1006
               G+LGL +E   +  SP  V L   ++V+ ++CG  HT VLT+
Sbjct: 255  PENGKLGLPNELLMNHRSPQRV-LGIPERVIQVACGGGHTVVLTE 298



 Score =  103 bits (257), Expect = 2e-22
 Identities = 63/206 (30%), Positives = 103/206 (50%), Gaps = 5/206 (2%)
 Frame = +2

Query: 230 MLCWGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGDHSVFLLEDGEVYTCGL 409
           +  WG  S GQ G+       +      G    + +  ++CG  HS F+  DGE+YT G 
Sbjct: 199 LFMWGDNSEGQIGLEDKSNVCIPHEVTVG----KPISWISCGYYHSAFVTMDGELYTFGE 254

Query: 410 NTKGQLGHERE----GNKPEQIGALADEHIVHVACGESHSLALSDRGQLFSWGAGSDGQL 577
              G+LG   E       P+++  +  E ++ VACG  H++ L+++  ++++G G  GQL
Sbjct: 255 PENGKLGLPNELLMNHRSPQRVLGIP-ERVIQVACGGGHTVVLTEK-VVYAFGLGQFGQL 312

Query: 578 GLMTTEESVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKE-F 754
           GL T     + P++I+++  Q I  +SCG  H   +   G  +T+G   HG+LGLG E F
Sbjct: 313 GLGTFLFETSEPKIIERIKDQKICHISCGENHTALMTELGLLYTFGDGRHGKLGLGMENF 372

Query: 755 PSQASPQRVRSLEGIPLAQVAAGGAH 832
            +Q  P    +     +  +A GG H
Sbjct: 373 TNQFFPTLCSNFLRFAVQLIACGGCH 398



 Score = 85.1 bits (209), Expect = 8e-17
 Identities = 61/235 (25%), Positives = 115/235 (48%), Gaps = 4/235 (1%)
 Frame = +2

Query: 305 QVCGFISDRSVKEVACGGDHSVFLLEDGEVYTCGLNTKGQLGHEREGNKPEQIGALADEH 484
           Q+  F    ++K+++ G + S  L EDG+++  G N++GQ+G E + N          + 
Sbjct: 170 QIVFFTPADTIKQLSAGANTSAALTEDGKLFMWGDNSEGQIGLEDKSNVCIPHEVTVGKP 229

Query: 485 IVHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTEESVAVPRLIQKL--NQQTILQVS 658
           I  ++CG  HS  ++  G+L+++G   +G+LGL    E +   R  Q++    + ++QV+
Sbjct: 230 ISWISCGYYHSAFVTMDGELYTFGEPENGKLGL--PNELLMNHRSPQRVLGIPERVIQVA 287

Query: 659 CGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSF 838
           CG  H + L  +   + +G    GQLGLG      + P+ +  ++   +  ++ G  H+ 
Sbjct: 288 CGGGHTVVL-TEKVVYAFGLGQFGQLGLGTFLFETSEPKIIERIKDQKICHISCGENHTA 346

Query: 839 ALSLSGAVFGWGMNNAGQLGLSDEE--DRESPCHVKLLRAQKVVYISCGEEHTAV 997
            ++  G ++ +G    G+LGL  E   ++  P          V  I+CG  H  V
Sbjct: 347 LMTELGLLYTFGDGRHGKLGLGMENFTNQFFPTLCSNFLRFAVQLIACGGCHMLV 401


  Database: RefSeq49_MP.fasta
    Posted date:  Oct 17, 2011  1:42 PM
  Number of letters in database: 15,617,559
  Number of sequences in database:  30,036
  
Lambda     K      H
   0.318    0.134    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 30036
Number of Hits to DB: 42,553,776
Number of extensions: 1330171
Number of successful extensions: 6394
Number of sequences better than 1.0e-05: 28
Number of HSP's gapped: 5941
Number of HSP's successfully gapped: 141
Length of query: 351
Length of database: 15,617,559
Length adjustment: 102
Effective length of query: 249
Effective length of database: 12,553,887
Effective search space: 3125917863
Effective search space used: 3125917863
Neighboring words threshold: 12
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 34 (17.7 bits)

BLASTX 2.2.24 [Aug-08-2010]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= 20110601C-003003
         (1053 letters)

Database: RefSeq49_SP.fasta 
           24,897 sequences; 11,343,932 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

Alignment   gi|XP_003129377.2| PREDICTED: probable E3 ubiquitin-protein lig...   535   e-157
Alignment   gi|XP_003129374.2| PREDICTED: probable E3 ubiquitin-protein lig...   375   e-109
Alignment   gi|XP_003359267.1| PREDICTED: probable E3 ubiquitin-protein lig...   268   4e-72
Alignment   gi|XP_003133446.2| PREDICTED: e3 ubiquitin-protein ligase HERC2...   163   2e-40
Alignment   gi|XP_001928937.1| PREDICTED: RCC1 and BTB domain-containing pr...   142   3e-34
Alignment   gi|XP_003357882.1| PREDICTED: RCC1 and BTB domain-containing pr...   138   6e-33
Alignment   gi|XP_003135065.2| PREDICTED: hypothetical protein LOC100511730...   132   3e-31
Alignment   gi|XP_003361480.1| PREDICTED: probable E3 ubiquitin-protein lig...   129   2e-30
Alignment   gi|XP_001927286.3| PREDICTED: probable E3 ubiquitin-protein lig...   129   2e-30
Alignment   gi|XP_003354559.1| PREDICTED: Williams-Beuren syndrome chromoso...   118   5e-27

>ref|XP_003129377.2| PREDICTED: probable E3 ubiquitin-protein ligase HERC3-like [Sus
            scrofa].
          Length = 370

 Score =  535 bits (1379), Expect(2) = e-157
 Identities = 259/259 (100%), Positives = 259/259 (100%)
 Frame = +2

Query: 230  MLCWGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGDHSVFLLEDGEVYTCGL 409
            MLCWGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGDHSVFLLEDGEVYTCGL
Sbjct: 1    MLCWGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGDHSVFLLEDGEVYTCGL 60

Query: 410  NTKGQLGHEREGNKPEQIGALADEHIVHVACGESHSLALSDRGQLFSWGAGSDGQLGLMT 589
            NTKGQLGHEREGNKPEQIGALADEHIVHVACGESHSLALSDRGQLFSWGAGSDGQLGLMT
Sbjct: 61   NTKGQLGHEREGNKPEQIGALADEHIVHVACGESHSLALSDRGQLFSWGAGSDGQLGLMT 120

Query: 590  TEESVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQAS 769
            TEESVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQAS
Sbjct: 121  TEESVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQAS 180

Query: 770  PQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEEDRESPCHVKLLR 949
            PQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEEDRESPCHVKLLR
Sbjct: 181  PQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEEDRESPCHVKLLR 240

Query: 950  AQKVVYISCGEEHTAVLTK 1006
            AQKVVYISCGEEHTAVLTK
Sbjct: 241  AQKVVYISCGEEHTAVLTK 259



 Score = 37.7 bits (86), Expect(2) = e-157
 Identities = 16/17 (94%), Positives = 16/17 (94%)
 Frame = +1

Query: 1003 KSGGVFTFGAGSCGPLG 1053
            KSGGVFTFGAGSCG LG
Sbjct: 259  KSGGVFTFGAGSCGQLG 275



 Score =  133 bits (334), Expect = 2e-31
 Identities = 92/274 (33%), Positives = 140/274 (51%), Gaps = 5/274 (1%)
 Frame = +2

Query: 230  MLCWGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGDHSVFLLEDGEVYTCGL 409
            +  WG  S GQ G+ T  +  VA P++   ++ +++ +V+CG  H + L  DG+ +T G 
Sbjct: 105  LFSWGAGSDGQLGLMTTEES-VAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGK 163

Query: 410  NTKGQLGHERE---GNKPEQIGALADEHIVHVACGESHSLALSDRGQLFSWGAGSDGQLG 580
            N+ GQLG  +E      P+++ +L    +  VA G +HS ALS  G +F WG  + GQLG
Sbjct: 164  NSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLG 223

Query: 581  LMTTEESVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPS 760
            L + EE    P  ++ L  Q ++ +SCG  H   L   G  FT+G  S GQLG       
Sbjct: 224  L-SDEEDRESPCHVKLLRAQKVVYISCGEEHTAVLTKSGGVFTFGAGSCGQLG-HDSMND 281

Query: 761  QASPQRVRSLEGIPLAQVAAGGAHSFA-LSLSGAVFGWGMNNAGQLGLSDEEDRESPCHV 937
            + +P+RV  L G  + Q+A G  H+ A +  SG ++ +G    GQLG          C+V
Sbjct: 282  EVNPRRVLELMGSEVTQIACGRQHTLAFVPSSGLIYAFGCGARGQLGTG------HTCNV 335

Query: 938  KLLRAQKVVYISCGEEHTAVLTKVEVC-LPLVLV 1036
            K     K  + +    H+  L+   VC LP V+V
Sbjct: 336  KCPSPVKGYWAA----HSGQLSARAVCHLPFVIV 365


>ref|XP_003129374.2| PREDICTED: probable E3 ubiquitin-protein ligase HERC3-like [Sus
            scrofa].
          Length = 989

 Score =  375 bits (963), Expect(2) = e-109
 Identities = 184/184 (100%), Positives = 184/184 (100%)
 Frame = +2

Query: 455  EQIGALADEHIVHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTEESVAVPRLIQKLN 634
            EQIGALADEHIVHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTEESVAVPRLIQKLN
Sbjct: 15   EQIGALADEHIVHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTEESVAVPRLIQKLN 74

Query: 635  QQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQV 814
            QQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQV
Sbjct: 75   QQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQV 134

Query: 815  AAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEEDRESPCHVKLLRAQKVVYISCGEEHTA 994
            AAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEEDRESPCHVKLLRAQKVVYISCGEEHTA
Sbjct: 135  AAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEEDRESPCHVKLLRAQKVVYISCGEEHTA 194

Query: 995  VLTK 1006
            VLTK
Sbjct: 195  VLTK 198



 Score = 37.7 bits (86), Expect(2) = e-109
 Identities = 16/17 (94%), Positives = 16/17 (94%)
 Frame = +1

Query: 1003 KSGGVFTFGAGSCGPLG 1053
            KSGGVFTFGAGSCG LG
Sbjct: 198  KSGGVFTFGAGSCGQLG 214



 Score =  131 bits (330), Expect = 5e-31
 Identities = 83/241 (34%), Positives = 127/241 (52%), Gaps = 4/241 (1%)
 Frame = +2

Query: 230 MLCWGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGDHSVFLLEDGEVYTCGL 409
           +  WG  S GQ G+ T  +  VA P++   ++ +++ +V+CG  H + L  DG+ +T G 
Sbjct: 44  LFSWGAGSDGQLGLMTTEES-VAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGK 102

Query: 410 NTKGQLGHERE---GNKPEQIGALADEHIVHVACGESHSLALSDRGQLFSWGAGSDGQLG 580
           N+ GQLG  +E      P+++ +L    +  VA G +HS ALS  G +F WG  + GQLG
Sbjct: 103 NSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLG 162

Query: 581 LMTTEESVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPS 760
           L + EE    P  ++ L  Q ++ +SCG  H   L   G  FT+G  S GQLG       
Sbjct: 163 L-SDEEDRESPCHVKLLRAQKVVYISCGEEHTAVLTKSGGVFTFGAGSCGQLG-HDSMND 220

Query: 761 QASPQRVRSLEGIPLAQVAAGGAHSFA-LSLSGAVFGWGMNNAGQLGLSDEEDRESPCHV 937
           + +P+RV  L G  + Q+A G  H+ A +  SG ++ +G    GQLG     + + P  V
Sbjct: 221 EVNPRRVLELMGSEVTQIACGRQHTLAFVPSSGLIYAFGCGARGQLGTGHTCNVKCPSPV 280

Query: 938 K 940
           K
Sbjct: 281 K 281


>ref|XP_003359267.1| PREDICTED: probable E3 ubiquitin-protein ligase HERC4-like [Sus
           scrofa].
          Length = 331

 Score =  268 bits (685), Expect = 4e-72
 Identities = 128/229 (55%), Positives = 168/229 (73%)
 Frame = +2

Query: 230 MLCWGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGDHSVFLLEDGEVYTCGL 409
           MLCWG  S GQ G+    + IV EP+   F  ++ V++V CG  H+VF+L+DG VYTCG 
Sbjct: 1   MLCWGNASFGQLGLGGIDEEIVLEPRKSDFFINKKVRDVGCGLRHTVFVLDDGTVYTCGC 60

Query: 410 NTKGQLGHEREGNKPEQIGALADEHIVHVACGESHSLALSDRGQLFSWGAGSDGQLGLMT 589
           N  GQLGHE+   KPEQ+ AL  ++IV V+CGE+H+LAL+D+GQ+++WG  SDGQLGL+ 
Sbjct: 61  NDLGQLGHEKSRKKPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGLLG 120

Query: 590 TEESVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQAS 769
           TEE + VPR I+ L+   I+QV+CG +H LAL+   + F WG+N +GQLGLG +   Q+S
Sbjct: 121 TEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGIDCKKQSS 180

Query: 770 PQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEED 916
           PQ ++SL GIP  QVAAGGAHSF L+LSGA+FGWG N  GQLGL+DE D
Sbjct: 181 PQLIKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDEND 229



 Score =  112 bits (280), Expect = 3e-25
 Identities = 74/200 (37%), Positives = 103/200 (51%), Gaps = 5/200 (2%)
 Frame = +2

Query: 419  GQLG----HEREGNKPEQIGALADEHIVHVACGESHSLALSDRGQLFSWGAGSDGQLGLM 586
            GQLG     E    +P +     ++ +  V CG  H++ + D G +++ G    GQLG  
Sbjct: 10   GQLGLGGIDEEIVLEPRKSDFFINKKVRDVGCGLRHTVFVLDDGTVYTCGCNDLGQLG-- 67

Query: 587  TTEESVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQA 766
              E+S   P  +  L+ Q I+ VSCG  H LAL   GQ + WG +S GQLGL        
Sbjct: 68   -HEKSRKKPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGLLGTEECIR 126

Query: 767  SPQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLS-DEEDRESPCHVKL 943
             P+ ++SL  I + QVA G  HS ALS +  VF WG N  GQLGL  D + + SP  +K 
Sbjct: 127  VPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGIDCKKQSSPQLIKS 186

Query: 944  LRAQKVVYISCGEEHTAVLT 1003
            L     + ++ G  H+ VLT
Sbjct: 187  LLGIPFMQVAAGGAHSFVLT 206


>ref|XP_003133446.2| PREDICTED: e3 ubiquitin-protein ligase HERC2-like [Sus scrofa].
          Length = 4292

 Score =  163 bits (412), Expect = 2e-40
 Identities = 93/271 (34%), Positives = 140/271 (51%), Gaps = 4/271 (1%)
 Frame = +2

Query: 239  WGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGDHSVFLLEDGEVYTCGLNTK 418
            WG    G+ G  + +     +P++   +  + ++++ACG  HS  L   GE+YT GL   
Sbjct: 2528 WGEGDDGKLGHFSRMN--CDKPRLIEALKTKRIRDIACGSSHSAALTSSGELYTWGLGEY 2585

Query: 419  GQLGHEREGN--KPEQIGALADEHIVHVACG--ESHSLALSDRGQLFSWGAGSDGQLGLM 586
            G+LGH       KP+ +  L    ++ VACG  ++ +LAL+D G +FSWG G  G+LG  
Sbjct: 2586 GRLGHGDNTTQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFSWGDGDFGKLG-R 2644

Query: 587  TTEESVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQA 766
               E   +P+ I++LN Q + Q+ CG    LAL   G  +TWGK  + +LG G +   + 
Sbjct: 2645 GGSEGCNIPQNIERLNGQGVCQIECGAQFSLALTKSGVVWTWGKGDYFRLGHGSDVHVR- 2703

Query: 767  SPQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEEDRESPCHVKLL 946
             PQ V  L G  +  VA G  H  A++ +G V+ WG N+ GQ G         P  V+ L
Sbjct: 2704 KPQVVEGLRGKKIVHVAVGALHCLAVTDAGQVYAWGDNDHGQQGNGTTTVNRKPTLVQGL 2763

Query: 947  RAQKVVYISCGEEHTAVLTKVEVCLPLVLVP 1039
              QK+  ++CG  H+   T V+V  P V  P
Sbjct: 2764 EGQKITRVACGSSHSVAWTTVDVATPSVHEP 2794



 Score =  134 bits (336), Expect = 1e-31
 Identities = 93/262 (35%), Positives = 136/262 (51%), Gaps = 9/262 (3%)
 Frame = +2

Query: 248  WSLGQPGISTNLQGI-VAEPQVCGFISDRSVKEVACGGDHSVFLLE-DGEVYTCGLNTKG 421
            W L        L+G  +  P     +S  +V +VA GG  S+F +  +G+VY CG  T G
Sbjct: 2421 WGLNDKDQLGGLKGSKIKVPSFSETLSALNVVQVA-GGSKSLFAVTVEGKVYACGEATNG 2479

Query: 422  QLGHEREGNK---PEQIGALADEHIVHVA--CGESHSLALSDRGQLFSWGAGSDGQLGLM 586
            +LG          P QI AL+   +  VA   G  H+ AL+  G++FSWG G DG+LG  
Sbjct: 2480 RLGLGISSGTVPIPRQITALSSYVVKKVAVHSGGRHATALTVDGKVFSWGEGDDGKLGHF 2539

Query: 587  TTEESVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQA 766
             +  +   PRLI+ L  + I  ++CG+ H  AL + G+ +TWG   +G+LG G +  +Q 
Sbjct: 2540 -SRMNCDKPRLIEALKTKRIRDIACGSSHSAALTSSGELYTWGLGEYGRLGHG-DNTTQL 2597

Query: 767  SPQRVRSLEGIPLAQVAAGG--AHSFALSLSGAVFGWGMNNAGQLGLSDEEDRESPCHVK 940
             P+ V+ L G  + QVA G   A + AL+  G VF WG  + G+LG    E    P +++
Sbjct: 2598 KPKMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFSWGDGDFGKLGRGGSEGCNIPQNIE 2657

Query: 941  LLRAQKVVYISCGEEHTAVLTK 1006
             L  Q V  I CG + +  LTK
Sbjct: 2658 RLNGQGVCQIECGAQFSLALTK 2679



 Score =  131 bits (330), Expect = 5e-31
 Identities = 77/245 (31%), Positives = 135/245 (55%), Gaps = 10/245 (4%)
 Frame = +2

Query: 302  PQVCGFISDRSVKEVACGGD--HSVFLLEDGEVYTCGLNTKGQLGHEREG--NKPEQIGA 469
            PQ+   ++ R++ ++A   D  H + L   GEVY+ G    G+LGH       +P+ I A
Sbjct: 485  PQLVQGLASRNIIKIAAHSDGHHYLALAATGEVYSWGCGDGGRLGHGDTVPLEEPKVISA 544

Query: 470  L----ADEHIVHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTEESVAVPRLIQKLNQ 637
                 A +H+VH+ACG ++S A++  G+L++WG G+ G+LG  ++E+  A+P L+  L  
Sbjct: 545  FSGKQAGKHVVHIACGSTYSAAITAEGELYTWGRGNYGRLGHGSSEDE-AIPMLVAGLKG 603

Query: 638  QTILQVSCGNW--HCLALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQ 811
              ++ V+CG+     LA+  +GQ ++WG   +G+LG G       +P+ +  L+ + + +
Sbjct: 604  LKVIDVACGSGDAQTLAVTENGQVWSWGDGDYGKLGRGGS-DGCKTPKLIEKLQDLDVVK 662

Query: 812  VAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEEDRESPCHVKLLRAQKVVYISCGEEHT 991
            V  G   S AL+  G V+ WG  +  +LG   EE    P  ++ L+ +KV+ ++ G  H 
Sbjct: 663  VRCGSQFSIALTKDGQVYSWGKGDNQRLGHGTEEHVRYPKLLEGLQGKKVIDVAAGSTHC 722

Query: 992  AVLTK 1006
              LT+
Sbjct: 723  LALTE 727



 Score =  126 bits (317), Expect = 2e-29
 Identities = 82/266 (30%), Positives = 132/266 (49%), Gaps = 8/266 (3%)
 Frame = +2

Query: 221  TQTMLCWGYWSLGQPGISTNLQGIVAEPQVCGFISDRS----VKEVACGGDHSVFLLEDG 388
            T  +  WG    G+ G    +   + EP+V    S +     V  +ACG  +S  +  +G
Sbjct: 514  TGEVYSWGCGDGGRLGHGDTVP--LEEPKVISAFSGKQAGKHVVHIACGSTYSAAITAEG 571

Query: 389  EVYTCGLNTKGQLGHEREGNK--PEQIGALADEHIVHVACG--ESHSLALSDRGQLFSWG 556
            E+YT G    G+LGH    ++  P  +  L    ++ VACG  ++ +LA+++ GQ++SWG
Sbjct: 572  ELYTWGRGNYGRLGHGSSEDEAIPMLVAGLKGLKVIDVACGSGDAQTLAVTENGQVWSWG 631

Query: 557  AGSDGQLGLMTTEESVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQL 736
             G  G+LG     +    P+LI+KL    +++V CG+   +AL  DGQ ++WGK  + +L
Sbjct: 632  DGDYGKLG-RGGSDGCKTPKLIEKLQDLDVVKVRCGSQFSIALTKDGQVYSWGKGDNQRL 690

Query: 737  GLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEED 916
            G G E      P+ +  L+G  +  VAAG  H  AL+    V  WG N+  Q   +    
Sbjct: 691  GHGTE-EHVRYPKLLEGLQGKKVIDVAAGSTHCLALTEDSEVHSWGSNDQCQHFDTLRVT 749

Query: 917  RESPCHVKLLRAQKVVYISCGEEHTA 994
            +  P  +  L  + +V I+CG    A
Sbjct: 750  KPEPSALPGLDTKHIVGIACGPAQKA 775



 Score =  126 bits (317), Expect = 2e-29
 Identities = 78/203 (38%), Positives = 117/203 (57%), Gaps = 5/203 (2%)
 Frame = +2

Query: 386  GEVYTCGLNTKGQLGHEREGNK---PEQIGALADEHIVHVACGESHSLALSDRGQLFSWG 556
            G +Y  G N +GQLG   EG K   P    ALA    V +  GE    A++  G+L++ G
Sbjct: 3411 GTIYGWGHNHRGQLGGI-EGAKVKVPTPCEALAALRPVQLIGGEQTLFAVTADGKLYATG 3469

Query: 557  AGSDGQLGLMTTEESVAVPRLIQKLNQQTI--LQVSCGNWHCLALAADGQFFTWGKNSHG 730
             G+ G+LG+  TE SV+ P L++ +    I  + V+ G  HCLAL+++G+ ++WG+   G
Sbjct: 3470 YGAGGRLGIGGTE-SVSTPTLLESIQHVFIKKVAVNSGGKHCLALSSEGEVYSWGEAEDG 3528

Query: 731  QLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDE 910
            +LG G   P    P+ + SL GI +  VAAGGAHS  ++ +G ++ WG    G+LG SD 
Sbjct: 3529 KLGHGNRSPCDR-PRVIESLRGIEVVDVAAGGAHSACVTAAGDLYTWGKGRYGRLGHSDS 3587

Query: 911  EDRESPCHVKLLRAQKVVYISCG 979
            ED+  P  V  L+  +VV ++CG
Sbjct: 3588 EDQLKPKLVDALQGHRVVDVACG 3610



 Score =  126 bits (317), Expect = 2e-29
 Identities = 83/261 (31%), Positives = 134/261 (51%), Gaps = 6/261 (2%)
 Frame = +2

Query: 242  GYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVAC--GGDHSVFLLEDGEVYTCGLNT 415
            GY + G+ GI       V+ P +   I    +K+VA   GG H + L  +GEVY+ G   
Sbjct: 3469 GYGAGGRLGIGGTES--VSTPTLLESIQHVFIKKVAVNSGGKHCLALSSEGEVYSWGEAE 3526

Query: 416  KGQLGHEREG--NKPEQIGALADEHIVHVACGESHSLALSDRGQLFSWGAGSDGQLGLMT 589
             G+LGH      ++P  I +L    +V VA G +HS  ++  G L++WG G  G+LG   
Sbjct: 3527 DGKLGHGNRSPCDRPRVIESLRGIEVVDVAAGGAHSACVTAAGDLYTWGKGRYGRLGHSD 3586

Query: 590  TEESVAVPRLIQKLNQQTILQVSCGNWHC--LALAADGQFFTWGKNSHGQLGLGKEFPSQ 763
            +E+ +  P+L+  L    ++ V+CG+     L L  D   ++WG   +G+LG G     +
Sbjct: 3587 SEDQLK-PKLVDALQGHRVVDVACGSGDAQTLCLTDDDTVWSWGDGDYGKLGRGGSDGCK 3645

Query: 764  ASPQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEEDRESPCHVKL 943
              P ++ SL G+ + +V  G   S AL+ SGAV+ WG  +  +LG   ++    P  V+ 
Sbjct: 3646 V-PMKIDSLTGLGVVKVECGSQFSVALTKSGAVYTWGKGDYHRLGHGSDDHVRRPRQVQG 3704

Query: 944  LRAQKVVYISCGEEHTAVLTK 1006
            L+ +KV+ I+ G  H    T+
Sbjct: 3705 LQGKKVIAIATGSLHCVCCTE 3725



 Score =  125 bits (314), Expect = 4e-29
 Identities = 77/234 (32%), Positives = 120/234 (51%), Gaps = 4/234 (1%)
 Frame = +2

Query: 302  PQVCGFISDRSVKEVACGGDHSVFLLEDGEVYTCGLNTKGQLGHEREGN--KPEQIGALA 475
            P+V   +    V +VA GG HS  +   G++YT G    G+LGH    +  KP+ + AL 
Sbjct: 3541 PRVIESLRGIEVVDVAAGGAHSACVTAAGDLYTWGKGRYGRLGHSDSEDQLKPKLVDALQ 3600

Query: 476  DEHIVHVACG--ESHSLALSDRGQLFSWGAGSDGQLGLMTTEESVAVPRLIQKLNQQTIL 649
               +V VACG  ++ +L L+D   ++SWG G  G+LG     +   VP  I  L    ++
Sbjct: 3601 GHRVVDVACGSGDAQTLCLTDDDTVWSWGDGDYGKLG-RGGSDGCKVPMKIDSLTGLGVV 3659

Query: 650  QVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGA 829
            +V CG+   +AL   G  +TWGK  + +LG G +      P++V+ L+G  +  +A G  
Sbjct: 3660 KVECGSQFSVALTKSGAVYTWGKGDYHRLGHGSD-DHVRRPRQVQGLQGKKVIAIATGSL 3718

Query: 830  HSFALSLSGAVFGWGMNNAGQLGLSDEEDRESPCHVKLLRAQKVVYISCGEEHT 991
            H    +  G+ + WG N+ GQLG       + P  V  L+ +KV  ++CG  HT
Sbjct: 3719 HCVCCTEDGS-YTWGDNDEGQLGDGTTNAIQRPRLVAALQGKKVNRVACGSAHT 3771



 Score =  117 bits (294), Expect = 8e-27
 Identities = 70/245 (28%), Positives = 127/245 (51%), Gaps = 7/245 (2%)
 Frame = +2

Query: 293  VAEPQVCGFISDRSVKEVACGGDHSVFLLEDGEVYTCGLNTKGQLGHEREGNKPEQIGAL 472
            V  P  C  +++  V ++AC     + L  +G VYT   N+        +   P+ +  L
Sbjct: 440  VIGPIQCEGLANLGVTQIACAEKRFLILSRNGRVYTQAYNS--------DTLAPQLVQGL 491

Query: 473  ADEHIVHVACGES--HSLALSDRGQLFSWGAGSDGQLG---LMTTEESVAVPRLIQKLNQ 637
            A  +I+ +A      H LAL+  G+++SWG G  G+LG    +  EE   +     K   
Sbjct: 492  ASRNIIKIAAHSDGHHYLALAATGEVYSWGCGDGGRLGHGDTVPLEEPKVISAFSGKQAG 551

Query: 638  QTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVA 817
            + ++ ++CG+ +  A+ A+G+ +TWG+ ++G+LG G     +A P  V  L+G+ +  VA
Sbjct: 552  KHVVHIACGSTYSAAITAEGELYTWGRGNYGRLGHGSS-EDEAIPMLVAGLKGLKVIDVA 610

Query: 818  --AGGAHSFALSLSGAVFGWGMNNAGQLGLSDEEDRESPCHVKLLRAQKVVYISCGEEHT 991
              +G A + A++ +G V+ WG  + G+LG    +  ++P  ++ L+   VV + CG + +
Sbjct: 611  CGSGDAQTLAVTENGQVWSWGDGDYGKLGRGGSDGCKTPKLIEKLQDLDVVKVRCGSQFS 670

Query: 992  AVLTK 1006
              LTK
Sbjct: 671  IALTK 675



 Score =  107 bits (268), Expect = 8e-24
 Identities = 65/209 (31%), Positives = 110/209 (52%), Gaps = 5/209 (2%)
 Frame = +2

Query: 389  EVYTCGLNTKGQLGHEREGNK---PEQIGALADEHIVHVACGESHSLALSDRGQLFSWGA 559
            +V+  GLN K QLG  + G+K   P     L+  ++V VA G     A++  G++++ G 
Sbjct: 2417 KVFVWGLNDKDQLGGLK-GSKIKVPSFSETLSALNVVQVAGGSKSLFAVTVEGKVYACGE 2475

Query: 560  GSDGQLGLMTTEESVAVPRLIQKLNQQTILQVS--CGNWHCLALAADGQFFTWGKNSHGQ 733
             ++G+LGL  +  +V +PR I  L+   + +V+   G  H  AL  DG+ F+WG+   G+
Sbjct: 2476 ATNGRLGLGISSGTVPIPRQITALSSYVVKKVAVHSGGRHATALTVDGKVFSWGEGDDGK 2535

Query: 734  LGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEE 913
            LG          P+ + +L+   +  +A G +HS AL+ SG ++ WG+   G+LG  D  
Sbjct: 2536 LGHFSRMNCD-KPRLIEALKTKRIRDIACGSSHSAALTSSGELYTWGLGEYGRLGHGDNT 2594

Query: 914  DRESPCHVKLLRAQKVVYISCGEEHTAVL 1000
             +  P  VK+L   +V+ ++CG      L
Sbjct: 2595 TQLKPKMVKVLLGHRVIQVACGSRDAQTL 2623



 Score = 99.4 bits (246), Expect = 3e-21
 Identities = 70/209 (33%), Positives = 112/209 (53%), Gaps = 4/209 (1%)
 Frame = +2

Query: 239  WGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACG-GD-HSVFLLEDGEVYTCGLN 412
            WG    G+ G S +   +  +P++   +    V +VACG GD  ++ L +D  V++ G  
Sbjct: 3574 WGKGRYGRLGHSDSEDQL--KPKLVDALQGHRVVDVACGSGDAQTLCLTDDDTVWSWGDG 3631

Query: 413  TKGQLGHE-REGNK-PEQIGALADEHIVHVACGESHSLALSDRGQLFSWGAGSDGQLGLM 586
              G+LG    +G K P +I +L    +V V CG   S+AL+  G +++WG G   +LG  
Sbjct: 3632 DYGKLGRGGSDGCKVPMKIDSLTGLGVVKVECGSQFSVALTKSGAVYTWGKGDYHRLG-H 3690

Query: 587  TTEESVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQA 766
             +++ V  PR +Q L  + ++ ++ G+ HC+    DG + TWG N  GQLG G     Q 
Sbjct: 3691 GSDDHVRRPRQVQGLQGKKVIAIATGSLHCVCCTEDGSY-TWGDNDEGQLGDGTTNAIQR 3749

Query: 767  SPQRVRSLEGIPLAQVAAGGAHSFALSLS 853
             P+ V +L+G  + +VA G AH+ A S S
Sbjct: 3750 -PRLVAALQGKKVNRVACGSAHTLAWSTS 3777



 Score = 88.2 bits (217), Expect = 7e-18
 Identities = 56/193 (29%), Positives = 91/193 (47%), Gaps = 6/193 (3%)
 Frame = +2

Query: 452  PEQIGALADEHIVHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTEESVAVPRLIQKL 631
            P Q   LA+  +  +AC E   L LS  G++++    SD              P+L+Q L
Sbjct: 443  PIQCEGLANLGVTQIACAEKRFLILSRNGRVYTQAYNSD-----------TLAPQLVQGL 491

Query: 632  NQQTILQVSCGN--WHCLALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIP- 802
              + I++++  +   H LALAA G+ ++WG    G+LG G   P +  P+ + +  G   
Sbjct: 492  ASRNIIKIAAHSDGHHYLALAATGEVYSWGCGDGGRLGHGDTVPLE-EPKVISAFSGKQA 550

Query: 803  ---LAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEEDRESPCHVKLLRAQKVVYIS 973
               +  +A G  +S A++  G ++ WG  N G+LG    ED   P  V  L+  KV+ ++
Sbjct: 551  GKHVVHIACGSTYSAAITAEGELYTWGRGNYGRLGHGSSEDEAIPMLVAGLKGLKVIDVA 610

Query: 974  CGEEHTAVLTKVE 1012
            CG      L   E
Sbjct: 611  CGSGDAQTLAVTE 623



 Score = 87.4 bits (215), Expect = 1e-17
 Identities = 48/163 (29%), Positives = 91/163 (55%), Gaps = 2/163 (1%)
 Frame = +2

Query: 521  ALSDRGQLFSWGAGSDGQLGLMTTEESVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQ 700
            A + R ++F WG     QLG +   + + VP   + L+   ++QV+ G+    A+  +G+
Sbjct: 2411 AATIRTKVFVWGLNDKDQLGGLKGSK-IKVPSFSETLSALNVVQVAGGSKSLFAVTVEGK 2469

Query: 701  FFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVA--AGGAHSFALSLSGAVFGWG 874
             +  G+ ++G+LGLG    +   P+++ +L    + +VA  +GG H+ AL++ G VF WG
Sbjct: 2470 VYACGEATNGRLGLGISSGTVPIPRQITALSSYVVKKVAVHSGGRHATALTVDGKVFSWG 2529

Query: 875  MNNAGQLGLSDEEDRESPCHVKLLRAQKVVYISCGEEHTAVLT 1003
              + G+LG     + + P  ++ L+ +++  I+CG  H+A LT
Sbjct: 2530 EGDDGKLGHFSRMNCDKPRLIEALKTKRIRDIACGSSHSAALT 2572



 Score = 73.9 bits (180), Expect = 1e-13
 Identities = 58/206 (28%), Positives = 93/206 (45%), Gaps = 5/206 (2%)
 Frame = +2

Query: 203  CMTP*RTQTMLCWG---YWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGDHSVF 373
            C+T     T+  WG   Y  LG+ G           P     ++   V +V CG   SV 
Sbjct: 3618 CLTD--DDTVWSWGDGDYGKLGRGGSDG-----CKVPMKIDSLTGLGVVKVECGSQFSVA 3670

Query: 374  LLEDGEVYTCGLNTKGQLGHEREGN--KPEQIGALADEHIVHVACGESHSLALSDRGQLF 547
            L + G VYT G     +LGH  + +  +P Q+  L  + ++ +A G  H +  ++ G  +
Sbjct: 3671 LTKSGAVYTWGKGDYHRLGHGSDDHVRRPRQVQGLQGKKVIAIATGSLHCVCCTEDGS-Y 3729

Query: 548  SWGAGSDGQLGLMTTEESVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSH 727
            +WG   +GQLG  TT  ++  PRL+  L  + + +V+CG+ H LA         W  +  
Sbjct: 3730 TWGDNDEGQLGDGTTN-AIQRPRLVAALQGKKVNRVACGSAHTLA---------WSTSKP 3779

Query: 728  GQLGLGKEFPSQASPQRVRSLEGIPL 805
               G   + P+Q  P     L+ IP+
Sbjct: 3780 ASAG---KLPAQV-PMEYNHLQEIPI 3801


>ref|XP_001928937.1| PREDICTED: RCC1 and BTB domain-containing protein 2 isoform 1 [Sus
           scrofa].
          Length = 568

 Score =  142 bits (358), Expect = 3e-34
 Identities = 84/254 (33%), Positives = 135/254 (53%), Gaps = 12/254 (4%)
 Frame = +2

Query: 269 ISTNLQGIVAEPQVCGFISDR-----SVKEVAC----GGDHSVFLLEDGEVYTCGLNTKG 421
           + TN  G +    V   I  R     S K++AC     G H V    +GEV+T G N   
Sbjct: 87  LGTNCCGCLGLGDVQSTIEPRRLDSLSGKKIACLSYGSGPHVVLATTEGEVFTWGHNAYS 146

Query: 422 QLGH--EREGNKPEQIGA-LADEHIVHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTT 592
           QLG+     G  P  I   L+++ ++ VACG  HSL L+  G++F+WG  + GQ+G  +T
Sbjct: 147 QLGNGTTNHGLVPCHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGST 206

Query: 593 EESVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQASP 772
                  R+   L  +T++ ++CG    +A+   G+ + WG N +GQLGLG    +Q +P
Sbjct: 207 ANQPIPRRVTGCLQNKTVVNIACGQMCSMAVVDTGEVYVWGYNGNGQLGLGSG-GNQPTP 265

Query: 773 QRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEEDRESPCHVKLLRA 952
            R+ +L+GI + +VA G AH+  L+  G V+ WG N+ GQLG  ++ ++  P  V + + 
Sbjct: 266 CRIAALQGIRVQRVACGYAHTLVLTDEGQVYAWGANSYGQLGTGNKSNQSYPTPVIVEKD 325

Query: 953 QKVVYISCGEEHTA 994
           + +   +C   HT+
Sbjct: 326 RIIEIAACHSAHTS 339



 Score =  123 bits (308), Expect = 2e-28
 Identities = 68/220 (30%), Positives = 119/220 (54%), Gaps = 4/220 (1%)
 Frame = +2

Query: 356  GDHSVFLLEDGEVYTCGLNTKG--QLGHEREGNKPEQIGALADEHIVHVACGES-HSLAL 526
            G+  ++   + E++  G N  G   LG  +   +P ++ +L+ + I  ++ G   H +  
Sbjct: 72   GNEVLYTTVNDEIFVLGTNCCGCLGLGDVQSTIEPRRLDSLSGKKIACLSYGSGPHVVLA 131

Query: 527  SDRGQLFSWGAGSDGQLGLMTTEESVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFF 706
            +  G++F+WG  +  QLG  TT   +    +   L+ + +++V+CG++H L L +DG+ F
Sbjct: 132  TTEGEVFTWGHNAYSQLGNGTTNHGLVPCHISTNLSNKQVIEVACGSYHSLVLTSDGEVF 191

Query: 707  TWGKNSHGQLGLGKEFPSQASPQRVRS-LEGIPLAQVAAGGAHSFALSLSGAVFGWGMNN 883
             WG N+ GQ+G G    +Q  P+RV   L+   +  +A G   S A+  +G V+ WG N 
Sbjct: 192  AWGYNNSGQVGSGST-ANQPIPRRVTGCLQNKTVVNIACGQMCSMAVVDTGEVYVWGYNG 250

Query: 884  AGQLGLSDEEDRESPCHVKLLRAQKVVYISCGEEHTAVLT 1003
             GQLGL    ++ +PC +  L+  +V  ++CG  HT VLT
Sbjct: 251  NGQLGLGSGGNQPTPCRIAALQGIRVQRVACGYAHTLVLT 290


>ref|XP_003357882.1| PREDICTED: RCC1 and BTB domain-containing protein 1 [Sus scrofa].
          Length = 531

 Score =  138 bits (347), Expect = 6e-33
 Identities = 77/233 (33%), Positives = 129/233 (55%), Gaps = 4/233 (1%)
 Frame = +2

Query: 308 VCGFISDRSVKEVACG-GDHSVFLLEDGEVYTCGLNTKGQLGH--EREGNKPEQIGA-LA 475
           +CG    + +K ++ G G H +   EDG VY  G N   QLG+    +G  P Q+   L 
Sbjct: 71  LCG----KKIKSLSYGSGPHVLLSTEDGVVYAWGHNGYSQLGNGTTNQGIAPIQVCTNLL 126

Query: 476 DEHIVHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTEESVAVPRLIQKLNQQTILQV 655
            + +V VACG  HS+AL+  G++F+WG  + GQ+G  +T       ++   L+ + ++ +
Sbjct: 127 IKQVVEVACGSHHSMALAADGEVFAWGYNNCGQVGSGSTANQPTPRKVTNCLHIKRVVSI 186

Query: 656 SCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHS 835
           +CG    +A+  +G+ + WG N +GQLGLG    +Q +P RV +L  + + Q+  G AH+
Sbjct: 187 ACGQTSSMAVLDNGEVYGWGYNGNGQLGLGNN-GNQLTPVRVAALHSVCVNQIVCGYAHT 245

Query: 836 FALSLSGAVFGWGMNNAGQLGLSDEEDRESPCHVKLLRAQKVVYISCGEEHTA 994
            AL+  G ++ WG N  GQLG  ++ +  SP H+ + + + V   +C   HT+
Sbjct: 246 LALTDEGLLYAWGANTYGQLGTGNKNNLLSPAHIMVEKERVVEIAACHSAHTS 298



 Score =  124 bits (312), Expect = 7e-29
 Identities = 77/216 (35%), Positives = 112/216 (51%), Gaps = 4/216 (1%)
 Frame = +2

Query: 239 WGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGDHSVFLLEDGEVYTCGLNTK 418
           WG+    Q G  T  QGI A  QVC  +  + V EVACG  HS+ L  DGEV+  G N  
Sbjct: 99  WGHNGYSQLGNGTTNQGI-APIQVCTNLLIKQVVEVACGSHHSMALAADGEVFAWGYNNC 157

Query: 419 GQLGHEREGNKP---EQIGALADEHIVHVACGESHSLALSDRGQLFSWGAGSDGQLGLMT 589
           GQ+G     N+P   +    L  + +V +ACG++ S+A+ D G+++ WG   +GQLGL  
Sbjct: 158 GQVGSGSTANQPTPRKVTNCLHIKRVVSIACGQTSSMAVLDNGEVYGWGYNGNGQLGLGN 217

Query: 590 TEESVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQAS 769
               +  P  +  L+   + Q+ CG  H LAL  +G  + WG N++GQLG G +  +  S
Sbjct: 218 NGNQL-TPVRVAALHSVCVNQIVCGYAHTLALTDEGLLYAWGANTYGQLGTGNK-NNLLS 275

Query: 770 PQRVRSLEGIPLAQVAAGGAH-SFALSLSGAVFGWG 874
           P  +   +   +   A   AH S A +  G V+ WG
Sbjct: 276 PAHIMVEKERVVEIAACHSAHTSAAKTQGGHVYMWG 311



 Score =  120 bits (301), Expect = 1e-27
 Identities = 72/219 (32%), Positives = 121/219 (55%), Gaps = 4/219 (1%)
 Frame = +2

Query: 359  DHSVFLLEDGEVYTCGLNTKGQLG--HEREGNKPEQIGALADEHIVHVACGES-HSLALS 529
            + ++++ ++ EV+  GLN    LG    +    P+++ AL  + I  ++ G   H L  +
Sbjct: 32   NEALYVTDNDEVFVFGLNYSNCLGTGDNQSTLVPKKLEALCGKKIKSLSYGSGPHVLLST 91

Query: 530  DRGQLFSWGAGSDGQLGLMTTEESVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFT 709
            + G +++WG     QLG  TT + +A  ++   L  + +++V+CG+ H +ALAADG+ F 
Sbjct: 92   EDGVVYAWGHNGYSQLGNGTTNQGIAPIQVCTNLLIKQVVEVACGSHHSMALAADGEVFA 151

Query: 710  WGKNSHGQLGLGKEFPSQASPQRVRSLEGIP-LAQVAAGGAHSFALSLSGAVFGWGMNNA 886
            WG N+ GQ+G G    +Q +P++V +   I  +  +A G   S A+  +G V+GWG N  
Sbjct: 152  WGYNNCGQVGSGST-ANQPTPRKVTNCLHIKRVVSIACGQTSSMAVLDNGEVYGWGYNGN 210

Query: 887  GQLGLSDEEDRESPCHVKLLRAQKVVYISCGEEHTAVLT 1003
            GQLGL +  ++ +P  V  L +  V  I CG  HT  LT
Sbjct: 211  GQLGLGNNGNQLTPVRVAALHSVCVNQIVCGYAHTLALT 249


>ref|XP_003135065.2| PREDICTED: hypothetical protein LOC100511730 [Sus scrofa].
          Length = 1224

 Score =  132 bits (332), Expect = 3e-31
 Identities = 92/262 (35%), Positives = 136/262 (51%), Gaps = 7/262 (2%)
 Frame = +2

Query: 239  WGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGDHSVFLLEDGEVYTCGLNTK 418
            WG   LG        +  V +P     +    VK  ACG +H++   E G+VY  G N +
Sbjct: 64   WGQLGLGS-------KSTVDKPTCVKALKPEKVKFAACGRNHTLISTEGGKVYAAGGNNE 116

Query: 419  GQ--LGHEREGNKPEQIGALADEH-IVHVACGESHSLALSDRGQLFSWGAGSDGQLGLMT 589
            GQ  LG   E N    I     +H I  ++ G + S AL++ G+LF WG  S+GQ+GL  
Sbjct: 117  GQLGLGDTEERNTFHVINFFTSQHKIKQLSAGSNTSAALTEDGELFMWGDNSEGQIGLQN 176

Query: 590  TEESVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKE-FPSQA 766
               S+ VP   Q    + I  +SCG +H   +  +G+ +T+G+   G+LGL ++   +  
Sbjct: 177  M-TSICVPH--QVTIGKPISWISCGYYHSAFVTTEGELYTFGEPECGKLGLPRKLLVNHR 233

Query: 767  SPQRVRSLEGIP--LAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSD-EEDRESPCHV 937
             PQ V    GIP  + QVA GG H+ AL+   AV+ +G+   GQLGL     +   P  +
Sbjct: 234  VPQLV---PGIPEKVIQVACGGGHTVALT-ENAVYVFGLGQFGQLGLGTFIFETSEPKVI 289

Query: 938  KLLRAQKVVYISCGEEHTAVLT 1003
              ++ QK+ YISCGE HTA++T
Sbjct: 290  DNIKDQKISYISCGENHTALIT 311



 Score =  100 bits (248), Expect = 2e-21
 Identities = 67/205 (32%), Positives = 103/205 (50%), Gaps = 4/205 (1%)
 Frame = +2

Query: 230 MLCWGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGDHSVFLLEDGEVYTCGL 409
           +  WG  S GQ G+  N+  I    QV      + +  ++CG  HS F+  +GE+YT G 
Sbjct: 161 LFMWGDNSEGQIGLQ-NMTSICVPHQVT---IGKPISWISCGYYHSAFVTTEGELYTFGE 216

Query: 410 NTKGQLGHERE---GNKPEQIGALADEHIVHVACGESHSLALSDRGQLFSWGAGSDGQLG 580
              G+LG  R+    ++  Q+     E ++ VACG  H++AL++   ++ +G G  GQLG
Sbjct: 217 PECGKLGLPRKLLVNHRVPQLVPGIPEKVIQVACGGGHTVALTENA-VYVFGLGQFGQLG 275

Query: 581 LMTTEESVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKE-FP 757
           L T     + P++I  +  Q I  +SCG  H   +   G  +T+G   HG+LGLG E F 
Sbjct: 276 LGTFIFETSEPKVIDNIKDQKISYISCGENHTALITDLGLMYTFGDGRHGKLGLGLENFT 335

Query: 758 SQASPQRVRSLEGIPLAQVAAGGAH 832
           +Q  P    +     +  VA GG H
Sbjct: 336 NQFIPTLCSNFLRFIVQLVACGGCH 360



 Score = 83.2 bits (204), Expect(2) = 6e-17
 Identities = 52/172 (30%), Positives = 87/172 (50%)
 Frame = +2

Query: 488  VHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTEESVAVPRLIQKLNQQTILQVSCGN 667
            V ++CG+ H+  ++   +LF +G+ + GQLGL  ++ +V  P  ++ L  + +   +CG 
Sbjct: 38   VSLSCGDEHTAIITGNNKLFMFGSNNWGQLGL-GSKSTVDKPTCVKALKPEKVKFAACGR 96

Query: 668  WHCLALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALS 847
             H L     G+ +  G N+ GQLGLG                   + Q++AG   S AL+
Sbjct: 97   NHTLISTEGGKVYAAGGNNEGQLGLGDTEERNTFHVINFFTSQHKIKQLSAGSNTSAALT 156

Query: 848  LSGAVFGWGMNNAGQLGLSDEEDRESPCHVKLLRAQKVVYISCGEEHTAVLT 1003
              G +F WG N+ GQ+GL +      P  V +   + + +ISCG  H+A +T
Sbjct: 157  EDGELFMWGDNSEGQIGLQNMTSICVPHQVTI--GKPISWISCGYYHSAFVT 206



 Score = 22.3 bits (46), Expect(2) = 6e-17
 Identities = 8/15 (53%), Positives = 10/15 (66%)
 Frame = +1

Query: 1009 GGVFTFGAGSCGPLG 1053
            G ++TFG   CG LG
Sbjct: 209  GELYTFGEPECGKLG 223



 Score = 65.9 bits (159), Expect = 4e-11
 Identities = 39/121 (32%), Positives = 64/121 (52%), Gaps = 1/121 (0%)
 Frame = +2

Query: 647  LQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGG 826
            + +SCG+ H   +  + + F +G N+ GQLGLG +  +   P  V++L+   +   A G 
Sbjct: 38   VSLSCGDEHTAIITGNNKLFMFGSNNWGQLGLGSK-STVDKPTCVKALKPEKVKFAACGR 96

Query: 827  AHSFALSLSGAVFGWGMNNAGQLGLSDEEDRESPCHVKLLRAQ-KVVYISCGEEHTAVLT 1003
             H+   +  G V+  G NN GQLGL D E+R +   +    +Q K+  +S G   +A LT
Sbjct: 97   NHTLISTEGGKVYAAGGNNEGQLGLGDTEERNTFHVINFFTSQHKIKQLSAGSNTSAALT 156

Query: 1004 K 1006
            +
Sbjct: 157  E 157



 Score = 49.7 bits (117), Expect = 3e-06
 Identities = 24/70 (34%), Positives = 42/70 (60%)
 Frame = +2

Query: 797  IPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEEDRESPCHVKLLRAQKVVYISC 976
            IP++ ++ G  H+  ++ +  +F +G NN GQLGL  +   + P  VK L+ +KV + +C
Sbjct: 36   IPVS-LSCGDEHTAIITGNNKLFMFGSNNWGQLGLGSKSTVDKPTCVKALKPEKVKFAAC 94

Query: 977  GEEHTAVLTK 1006
            G  HT + T+
Sbjct: 95   GRNHTLISTE 104


>ref|XP_003361480.1| PREDICTED: probable E3 ubiquitin-protein ligase HERC1-like, partial
            [Sus scrofa].
          Length = 2771

 Score =  129 bits (325), Expect = 2e-30
 Identities = 97/308 (31%), Positives = 140/308 (45%), Gaps = 55/308 (17%)
 Frame = +2

Query: 245  YWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGD-HSVFLLEDGEVYTCGLNTKG 421
            Y  LGQ G S +L  +     + GF+  + V   +CG D HS+ L E GEV++ G    G
Sbjct: 1966 YGRLGQ-GNSDDLHVLTVISALQGFVVTQLV--TSCGSDGHSMALTESGEVFSWGDGDYG 2022

Query: 422  QLGHEREGN--KPEQIGALADEHIVHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTE 595
            +LGH       +P QI AL  E +V ++CG  HS  ++  G+LF++G G  G+LGL  T 
Sbjct: 2023 KLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLGLGNTS 2082

Query: 596  ESVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQF-FTWGKNSHGQLGLG----KEFPS 760
                +P  +  L    I QV+CG  H LA++ADG   + +G   +G+LGLG    K  P 
Sbjct: 2083 NK-KLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNSTAKSSPQ 2141

Query: 761  QAS-----------------------------------------------PQRVRSLEGI 799
            +                                                 PQ++  L G+
Sbjct: 2142 KVDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGLPEGRARNHNRPQQIPVLAGV 2201

Query: 800  PLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEEDRESPCHVKLLRAQKVVYISCG 979
             +  VA G  H+ AL+ +G V+ WG N+ GQLGL        P  V +L+ + V  IS G
Sbjct: 2202 VIEDVAVGAEHTLALASTGDVYAWGSNSEGQLGLGHTNHVREPTLVTVLQGKNVRQISAG 2261

Query: 980  EEHTAVLT 1003
              H+A  T
Sbjct: 2262 RCHSAAWT 2269



 Score =  127 bits (318), Expect = 1e-29
 Identities = 84/262 (32%), Positives = 138/262 (52%), Gaps = 9/262 (3%)
 Frame = +2

Query: 248  WSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGDHSVFLLEDGEVYTCGLNTKGQL 427
            W  G+ G        V  P      S    ++V CG + +  +  +G V  CG  + G+L
Sbjct: 1912 WGAGRHGQLAEAGRNVMVPAAAPSFSQ--AQQVICGQNCTFVIQANGTVLACGEGSYGRL 1969

Query: 428  GHEREGNKPEQ-----IGALADEHIVHV--ACG-ESHSLALSDRGQLFSWGAGSDGQLGL 583
            G   +GN  +      I AL    +  +  +CG + HS+AL++ G++FSWG G  G+LG 
Sbjct: 1970 G---QGNSDDLHVLTVISALQGFVVTQLVTSCGSDGHSMALTESGEVFSWGDGDYGKLGH 2026

Query: 584  MTTEESVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQ 763
              ++     PR I+ L  + ++Q+SCG  H   + +DG+ FT+G   +G+LGLG    ++
Sbjct: 2027 GNSDRQRR-PRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLGLGNT-SNK 2084

Query: 764  ASPQRVRSLEGIPLAQVAAGGAHSFALSLSGA-VFGWGMNNAGQLGLSDEEDRESPCHVK 940
              P+RV +LEG  + QVA G  H+ A+S  G+ V+ +G  + G+LGL +   + SP  V 
Sbjct: 2085 KLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNSTAKSSPQKVD 2144

Query: 941  LLRAQKVVYISCGEEHTAVLTK 1006
            +L    +  ++CG + +  LTK
Sbjct: 2145 VLCGIGIKKVACGTQFSVALTK 2166



 Score = 92.0 bits (227), Expect = 5e-19
 Identities = 59/208 (28%), Positives = 105/208 (50%), Gaps = 3/208 (1%)
 Frame = +2

Query: 389  EVYTCGLNTKGQLGHEREGNKPEQIGALADEHIVHVACGESHSLALSDRGQLFSWGAGSD 568
            +VY  G    GQL  E   N      A +      V CG++ +  +   G + + G GS 
Sbjct: 1908 DVYLWGAGRHGQLA-EAGRNVMVPAAAPSFSQAQQVICGQNCTFVIQANGTVLACGEGSY 1966

Query: 569  GQLGLMTTEESVAVPRLIQKLNQQTILQV--SCGN-WHCLALAADGQFFTWGKNSHGQLG 739
            G+LG   +++ + V  +I  L    + Q+  SCG+  H +AL   G+ F+WG   +G+LG
Sbjct: 1967 GRLGQGNSDD-LHVLTVISALQGFVVTQLVTSCGSDGHSMALTESGEVFSWGDGDYGKLG 2025

Query: 740  LGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEEDR 919
             G     Q  P+++ +L+G  + Q++ G  HS  ++  G +F +G  + G+LGL +  ++
Sbjct: 2026 HGNS-DRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLGLGNTSNK 2084

Query: 920  ESPCHVKLLRAQKVVYISCGEEHTAVLT 1003
            + P  V  L   ++  ++CG  HT  ++
Sbjct: 2085 KLPERVTALEGYQIGQVACGLNHTLAVS 2112



 Score = 87.8 bits (216), Expect = 9e-18
 Identities = 53/134 (39%), Positives = 72/134 (53%), Gaps = 2/134 (1%)
 Frame = +2

Query: 296  AEPQVCGFISDRSVKEVACGGDHSVFLLEDGEVYTCGLNTKGQL--GHEREGNKPEQIGA 469
            + PQ    +    +K+VACG   SV L +DG VYT G +    L  G  R  N+P+QI  
Sbjct: 2138 SSPQKVDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGLPEGRARNHNRPQQIPV 2197

Query: 470  LADEHIVHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTEESVAVPRLIQKLNQQTIL 649
            LA   I  VA G  H+LAL+  G +++WG+ S+GQLGL  T   V  P L+  L  + + 
Sbjct: 2198 LAGVVIEDVAVGAEHTLALASTGDVYAWGSNSEGQLGLGHTNH-VREPTLVTVLQGKNVR 2256

Query: 650  QVSCGNWHCLALAA 691
            Q+S G  H  A  A
Sbjct: 2257 QISAGRCHSAAWTA 2270



 Score = 84.0 bits (206), Expect = 1e-16
 Identities = 55/179 (30%), Positives = 86/179 (48%), Gaps = 3/179 (1%)
 Frame = +2

Query: 476  DEHIVHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTEESVAVPRLIQKLNQQTILQV 655
            DE I+  A        L  +  ++ WGAG  GQL       +V VP      +Q    QV
Sbjct: 1887 DEQIMSWATSRPEDWHLGGKCDVYLWGAGRHGQLA--EAGRNVMVPAAAPSFSQAQ--QV 1942

Query: 656  SCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAG---G 826
             CG      + A+G     G+ S+G+LG G           + +L+G  + Q+       
Sbjct: 1943 ICGQNCTFVIQANGTVLACGEGSYGRLGQGNSDDLHVLTV-ISALQGFVVTQLVTSCGSD 2001

Query: 827  AHSFALSLSGAVFGWGMNNAGQLGLSDEEDRESPCHVKLLRAQKVVYISCGEEHTAVLT 1003
             HS AL+ SG VF WG  + G+LG  + + +  P  ++ L+ ++VV +SCG +H+AV+T
Sbjct: 2002 GHSMALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVT 2060


>ref|XP_001927286.3| PREDICTED: probable E3 ubiquitin-protein ligase HERC1 [Sus scrofa].
          Length = 4807

 Score =  129 bits (325), Expect = 2e-30
 Identities = 97/308 (31%), Positives = 140/308 (45%), Gaps = 55/308 (17%)
 Frame = +2

Query: 245  YWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGD-HSVFLLEDGEVYTCGLNTKG 421
            Y  LGQ G S +L  +     + GF+  + V   +CG D HS+ L E GEV++ G    G
Sbjct: 4002 YGRLGQ-GNSDDLHVLTVISALQGFVVTQLV--TSCGSDGHSMALTESGEVFSWGDGDYG 4058

Query: 422  QLGHEREGN--KPEQIGALADEHIVHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTE 595
            +LGH       +P QI AL  E +V ++CG  HS  ++  G+LF++G G  G+LGL  T 
Sbjct: 4059 KLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLGLGNTS 4118

Query: 596  ESVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQF-FTWGKNSHGQLGLG----KEFPS 760
                +P  +  L    I QV+CG  H LA++ADG   + +G   +G+LGLG    K  P 
Sbjct: 4119 NK-KLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNSTAKSSPQ 4177

Query: 761  QAS-----------------------------------------------PQRVRSLEGI 799
            +                                                 PQ++  L G+
Sbjct: 4178 KVDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGLPEGRARNHNRPQQIPVLAGV 4237

Query: 800  PLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEEDRESPCHVKLLRAQKVVYISCG 979
             +  VA G  H+ AL+ +G V+ WG N+ GQLGL        P  V +L+ + V  IS G
Sbjct: 4238 VIEDVAVGAEHTLALASTGDVYAWGSNSEGQLGLGHTNHVREPTLVTVLQGKNVRQISAG 4297

Query: 980  EEHTAVLT 1003
              H+A  T
Sbjct: 4298 RCHSAAWT 4305



 Score =  127 bits (318), Expect = 1e-29
 Identities = 84/262 (32%), Positives = 138/262 (52%), Gaps = 9/262 (3%)
 Frame = +2

Query: 248  WSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGDHSVFLLEDGEVYTCGLNTKGQL 427
            W  G+ G        V  P      S    ++V CG + +  +  +G V  CG  + G+L
Sbjct: 3948 WGAGRHGQLAEAGRNVMVPAAAPSFSQ--AQQVICGQNCTFVIQANGTVLACGEGSYGRL 4005

Query: 428  GHEREGNKPEQ-----IGALADEHIVHV--ACG-ESHSLALSDRGQLFSWGAGSDGQLGL 583
            G   +GN  +      I AL    +  +  +CG + HS+AL++ G++FSWG G  G+LG 
Sbjct: 4006 G---QGNSDDLHVLTVISALQGFVVTQLVTSCGSDGHSMALTESGEVFSWGDGDYGKLGH 4062

Query: 584  MTTEESVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQ 763
              ++     PR I+ L  + ++Q+SCG  H   + +DG+ FT+G   +G+LGLG    ++
Sbjct: 4063 GNSDRQRR-PRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLGLGNT-SNK 4120

Query: 764  ASPQRVRSLEGIPLAQVAAGGAHSFALSLSGA-VFGWGMNNAGQLGLSDEEDRESPCHVK 940
              P+RV +LEG  + QVA G  H+ A+S  G+ V+ +G  + G+LGL +   + SP  V 
Sbjct: 4121 KLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNSTAKSSPQKVD 4180

Query: 941  LLRAQKVVYISCGEEHTAVLTK 1006
            +L    +  ++CG + +  LTK
Sbjct: 4181 VLCGIGIKKVACGTQFSVALTK 4202



 Score =  120 bits (300), Expect = 2e-27
 Identities = 67/173 (38%), Positives = 100/173 (57%), Gaps = 3/173 (1%)
 Frame = +2

Query: 332  SVKEVACGGDHSVFLLEDGE-VYTCGLNTKGQLGHEREGN--KPEQIGALADEHIVHVAC 502
            +V EV+CG  H++ L +DG  V++ G    G+LGH       KP+ I AL    I  V  
Sbjct: 562  NVGEVSCGSSHTIALSKDGRTVWSFGGGDNGKLGHGDTNRVYKPKVIEALQGMFIRKVCA 621

Query: 503  GESHSLALSDRGQLFSWGAGSDGQLGLMTTEESVAVPRLIQKLNQQTILQVSCGNWHCLA 682
            G   SLAL+  GQ+++WG G+   LG  ++E +   P+LI++L    I+ +S G+ HCLA
Sbjct: 622  GSQSSLALTSTGQVYAWGCGAC--LGCGSSEATALRPKLIEELAATRIVDISIGDSHCLA 679

Query: 683  LAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFA 841
            L+ D + + WG NS GQ G G        P++V  L+GI + Q++AG +HS A
Sbjct: 680  LSHDNEVYAWGNNSMGQCGQGNSTGPITKPKKVSGLDGIAIQQISAGTSHSLA 732



 Score =  105 bits (263), Expect = 3e-23
 Identities = 79/260 (30%), Positives = 120/260 (46%), Gaps = 5/260 (1%)
 Frame = +2

Query: 239  WG---YWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGDHSVFLLEDGEVYTCGL 409
            WG   Y  LG    ST     + +    G +  + V  V+ G  HS  + EDGE+YT G 
Sbjct: 482  WGDGDYGKLGHGNSSTQKYPKLIQ----GPLQGKVVVCVSAGYRHSAAVTEDGELYTWGE 537

Query: 410  NTKGQLGHEREGNKPEQIGALADEHIVHVACGESHSLALSDRGQ-LFSWGAGSDGQLGLM 586
               G+LGH    ++          ++  V+CG SH++ALS  G+ ++S+G G +G+LG  
Sbjct: 538  GDFGRLGHGDSNSRNIPTLVKDISNVGEVSCGSSHTIALSKDGRTVWSFGGGDNGKLGHG 597

Query: 587  TTEESVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQA 766
             T   V  P++I+ L    I +V  G+   LAL + GQ + WG  +   LG G    +  
Sbjct: 598  DTNR-VYKPKVIEALQGMFIRKVCAGSQSSLALTSTGQVYAWGCGAC--LGCGSSEATAL 654

Query: 767  SPQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEEDR-ESPCHVKL 943
             P+ +  L    +  ++ G +H  ALS    V+ WG N+ GQ G  +       P  V  
Sbjct: 655  RPKLIEELAATRIVDISIGDSHCLALSHDNEVYAWGNNSMGQCGQGNSTGPITKPKKVSG 714

Query: 944  LRAQKVVYISCGEEHTAVLT 1003
            L    +  IS G  H+   T
Sbjct: 715  LDGIAIQQISAGTSHSLAWT 734



 Score = 93.6 bits (231), Expect = 2e-19
 Identities = 73/263 (27%), Positives = 122/263 (46%), Gaps = 8/263 (3%)
 Frame = +2

Query: 239  WGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGDHSVFLLE-DGEVYTCGLNT 415
            WG  S  Q  +    Q  + +P++    SD    E    G +  F++  DG V  CG  +
Sbjct: 377  WGSNSSHQ--LVEGTQEKILQPKLAPSFSDAQTIEA---GQYCTFVISTDGSVRACGKGS 431

Query: 416  KGQLGHEREGNKPEQIGALADEH-----IVHVACGESHSLALSDRGQLFSWGAGSDGQLG 580
             G+LG     N+        + H     +      + H+LA +  G++FSWG G  G+LG
Sbjct: 432  YGRLGLGDSNNQSTLKKLTFEPHRSIKKVSSSKGSDGHTLAFTTEGEVFSWGDGDYGKLG 491

Query: 581  LMTTEESVAVPRLIQ-KLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFP 757
                  +   P+LIQ  L  + ++ VS G  H  A+  DG+ +TWG+   G+LG G +  
Sbjct: 492  -HGNSSTQKYPKLIQGPLQGKVVVCVSAGYRHSAAVTEDGELYTWGEGDFGRLGHG-DSN 549

Query: 758  SQASPQRVRSLEGIPLAQVAAGGAHSFALSLSG-AVFGWGMNNAGQLGLSDEEDRESPCH 934
            S+  P  V+ +  +   +V+ G +H+ ALS  G  V+ +G  + G+LG  D      P  
Sbjct: 550  SRNIPTLVKDISNV--GEVSCGSSHTIALSKDGRTVWSFGGGDNGKLGHGDTNRVYKPKV 607

Query: 935  VKLLRAQKVVYISCGEEHTAVLT 1003
            ++ L+   +  +  G + +  LT
Sbjct: 608  IEALQGMFIRKVCAGSQSSLALT 630



 Score = 92.0 bits (227), Expect = 5e-19
 Identities = 59/208 (28%), Positives = 105/208 (50%), Gaps = 3/208 (1%)
 Frame = +2

Query: 389  EVYTCGLNTKGQLGHEREGNKPEQIGALADEHIVHVACGESHSLALSDRGQLFSWGAGSD 568
            +VY  G    GQL  E   N      A +      V CG++ +  +   G + + G GS 
Sbjct: 3944 DVYLWGAGRHGQLA-EAGRNVMVPAAAPSFSQAQQVICGQNCTFVIQANGTVLACGEGSY 4002

Query: 569  GQLGLMTTEESVAVPRLIQKLNQQTILQV--SCGN-WHCLALAADGQFFTWGKNSHGQLG 739
            G+LG   +++ + V  +I  L    + Q+  SCG+  H +AL   G+ F+WG   +G+LG
Sbjct: 4003 GRLGQGNSDD-LHVLTVISALQGFVVTQLVTSCGSDGHSMALTESGEVFSWGDGDYGKLG 4061

Query: 740  LGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEEDR 919
             G     Q  P+++ +L+G  + Q++ G  HS  ++  G +F +G  + G+LGL +  ++
Sbjct: 4062 HGNS-DRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLGLGNTSNK 4120

Query: 920  ESPCHVKLLRAQKVVYISCGEEHTAVLT 1003
            + P  V  L   ++  ++CG  HT  ++
Sbjct: 4121 KLPERVTALEGYQIGQVACGLNHTLAVS 4148



 Score = 88.2 bits (217), Expect = 7e-18
 Identities = 72/246 (29%), Positives = 119/246 (48%), Gaps = 12/246 (4%)
 Frame = +2

Query: 305  QVCGFISDRSVKEVACGGDHSV------FLLEDGEVYTCGLNTKGQL--GHEREGNKPEQ 460
            +VC   SD S     C    S+       + E  EVY  G N+  QL  G + +  +P+ 
Sbjct: 342  EVCRMASDYSR---TCASPDSIQTGDAPIVSETCEVYVWGSNSSHQLVEGTQEKILQPKL 398

Query: 461  IGALADEHIVHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTEESVAVPRLIQKLNQQ 640
              + +D   +    G+  +  +S  G + + G GS G+LGL  +     + +L  + ++ 
Sbjct: 399  APSFSDAQTIEA--GQYCTFVISTDGSVRACGKGSYGRLGLGDSNNQSTLKKLTFEPHR- 455

Query: 641  TILQVSCG---NWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRS-LEGIPLA 808
            +I +VS     + H LA   +G+ F+WG   +G+LG G    +Q  P+ ++  L+G  + 
Sbjct: 456  SIKKVSSSKGSDGHTLAFTTEGEVFSWGDGDYGKLGHGNS-STQKYPKLIQGPLQGKVVV 514

Query: 809  QVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEEDRESPCHVKLLRAQKVVYISCGEEH 988
             V+AG  HS A++  G ++ WG  + G+LG  D   R  P  VK +    V  +SCG  H
Sbjct: 515  CVSAGYRHSAAVTEDGELYTWGEGDFGRLGHGDSNSRNIPTLVKDI--SNVGEVSCGSSH 572

Query: 989  TAVLTK 1006
            T  L+K
Sbjct: 573  TIALSK 578



 Score = 87.8 bits (216), Expect = 9e-18
 Identities = 53/134 (39%), Positives = 72/134 (53%), Gaps = 2/134 (1%)
 Frame = +2

Query: 296  AEPQVCGFISDRSVKEVACGGDHSVFLLEDGEVYTCGLNTKGQL--GHEREGNKPEQIGA 469
            + PQ    +    +K+VACG   SV L +DG VYT G +    L  G  R  N+P+QI  
Sbjct: 4174 SSPQKVDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGLPEGRARNHNRPQQIPV 4233

Query: 470  LADEHIVHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTEESVAVPRLIQKLNQQTIL 649
            LA   I  VA G  H+LAL+  G +++WG+ S+GQLGL  T   V  P L+  L  + + 
Sbjct: 4234 LAGVVIEDVAVGAEHTLALASTGDVYAWGSNSEGQLGLGHTNH-VREPTLVTVLQGKNVR 4292

Query: 650  QVSCGNWHCLALAA 691
            Q+S G  H  A  A
Sbjct: 4293 QISAGRCHSAAWTA 4306



 Score = 84.0 bits (206), Expect = 1e-16
 Identities = 55/179 (30%), Positives = 86/179 (48%), Gaps = 3/179 (1%)
 Frame = +2

Query: 476  DEHIVHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTEESVAVPRLIQKLNQQTILQV 655
            DE I+  A        L  +  ++ WGAG  GQL       +V VP      +Q    QV
Sbjct: 3923 DEQIMSWATSRPEDWHLGGKCDVYLWGAGRHGQLA--EAGRNVMVPAAAPSFSQAQ--QV 3978

Query: 656  SCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAG---G 826
             CG      + A+G     G+ S+G+LG G           + +L+G  + Q+       
Sbjct: 3979 ICGQNCTFVIQANGTVLACGEGSYGRLGQGNSDDLHVLTV-ISALQGFVVTQLVTSCGSD 4037

Query: 827  AHSFALSLSGAVFGWGMNNAGQLGLSDEEDRESPCHVKLLRAQKVVYISCGEEHTAVLT 1003
             HS AL+ SG VF WG  + G+LG  + + +  P  ++ L+ ++VV +SCG +H+AV+T
Sbjct: 4038 GHSMALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVT 4096



 Score = 69.3 bits (168), Expect = 3e-12
 Identities = 45/144 (31%), Positives = 68/144 (47%), Gaps = 4/144 (2%)
 Frame = +2

Query: 293  VAEPQVCGFISDRSVKEVACGGDHSVFLLEDGEVYTCGLNT-KGQLGHEREGNKPEQIGA 469
            V +P+V   +    +++V  G   S+ L   G+VY  G     G    E    +P+ I  
Sbjct: 602  VYKPKVIEALQGMFIRKVCAGSQSSLALTSTGQVYAWGCGACLGCGSSEATALRPKLIEE 661

Query: 470  LADEHIVHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTEESVAVPRLIQKLNQQTIL 649
            LA   IV ++ G+SH LALS   ++++WG  S GQ G   +   +  P+ +  L+   I 
Sbjct: 662  LAATRIVDISIGDSHCLALSHDNEVYAWGNNSMGQCGQGNSTGPITKPKKVSGLDGIAIQ 721

Query: 650  QVSCGNWHCL---ALAADGQFFTW 712
            Q+S G  H L   AL  D Q   W
Sbjct: 722  QISAGTSHSLAWTALPRDRQVVAW 745


>ref|XP_003354559.1| PREDICTED: Williams-Beuren syndrome chromosomal region 16 protein
           homolog [Sus scrofa].
          Length = 498

 Score =  118 bits (296), Expect = 5e-27
 Identities = 80/226 (35%), Positives = 112/226 (49%), Gaps = 11/226 (4%)
 Frame = +2

Query: 326 DRSVKEVACGGDHSVFLLEDGEVYTCGLNTKGQ--LGHEREGNKPEQIGA-LADEHIVHV 496
           D  V +VACG DHS+FL + GEVY+CG    GQ  LGH    + P ++G  LA  ++V V
Sbjct: 235 DGQVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSAPTKLGGDLAGVNVVQV 294

Query: 497 ACGESHSLALSDRGQLFSWGAGSDGQLGLMTTEESVAVPRLIQKLNQQTILQVSCGNWHC 676
           A      LA+S  G LF WG     QL  +T    V VPR +       + Q +CG   C
Sbjct: 295 ATYGDCCLAVSADGSLFGWGNSEYLQLASVTDSTQVNVPRCLPFSGVGQVKQAACGGTGC 354

Query: 677 LALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVR-SLEGIP-------LAQVAAGGAH 832
             L  +G  F WG   +G LG G      A P+ +  +L G+        ++++  G +H
Sbjct: 355 AVLNGEGHVFVWG---YGILGKGPNLVETALPEMIPPTLFGLTELNPEVRVSRIRCGLSH 411

Query: 833 SFALSLSGAVFGWGMNNAGQLGLSDEEDRESPCHVKLLRAQKVVYI 970
             AL+  G +F WG N  G LG+   ED+  P  V+L  A + V +
Sbjct: 412 FAALTDRGELFVWGKNIRGCLGIGRLEDQYFPWRVRLRSAGRGVRV 457



 Score = 97.1 bits (240), Expect = 1e-20
 Identities = 76/240 (31%), Positives = 115/240 (47%), Gaps = 14/240 (5%)
 Frame = +2

Query: 326  DRSVKEVACGGDHSVFLLEDGEVYTCGLNTKGQLGHE-------REGNKPEQIGALADEH 484
            +  V +V+CG  HS+ L +   V++ G N+ GQ G +        E +K  ++    D  
Sbjct: 179  ETQVLQVSCGRAHSLVLTDGEGVFSMGNNSYGQCGRKVVENEIYSESHKVHRMQDF-DGQ 237

Query: 485  IVHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTEESVAVPRLIQKLNQQTILQVSCG 664
            +V VACG+ HSL L+D+G+++S G G+DGQ GL     + A  +L   L    ++QV+  
Sbjct: 238  VVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSAPTKLGGDLAGVNVVQVATY 297

Query: 665  NWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGI-PLAQVAAGGAHSFA 841
               CLA++ADG  F WG + + QL    +  +Q +  R     G+  + Q A GG     
Sbjct: 298  GDCCLAVSADGSLFGWGNSEYLQLASVTD-STQVNVPRCLPFSGVGQVKQAACGGTGCAV 356

Query: 842  LSLSGAVFGWGMNNAGQ---LGLSDEEDRESPCHVKLLRAQKVVYIS---CGEEHTAVLT 1003
            L+  G VF WG    G+   L  +   +   P    L      V +S   CG  H A LT
Sbjct: 357  LNGEGHVFVWGYGILGKGPNLVETALPEMIPPTLFGLTELNPEVRVSRIRCGLSHFAALT 416



 Score = 62.0 bits (149), Expect = 5e-10
 Identities = 51/169 (30%), Positives = 73/169 (43%), Gaps = 18/169 (10%)
 Frame = +2

Query: 476 DEHIVHVACGESHSLALS---DRGQLFSWGAGSDGQLGLMTTE-----------ESVAVP 613
           D+ I   ACG   +L  S   D  +++  G   D QLG   +            E   VP
Sbjct: 112 DQKISSAACGYGFTLLSSKTRDVTKVWGMGLNKDSQLGFHRSRKDKTRGYEYVLEPSPVP 171

Query: 614 RLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLG---LGKEFPSQA-SPQRV 781
             + +  +  +LQVSCG  H L L      F+ G NS+GQ G   +  E  S++    R+
Sbjct: 172 LPLHRPQETQVLQVSCGRAHSLVLTDGEGVFSMGNNSYGQCGRKVVENEIYSESHKVHRM 231

Query: 782 RSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEEDRESP 928
           +  +G  + QVA G  HS  L+  G V+  G    GQ GL       +P
Sbjct: 232 QDFDG-QVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSAP 279



 Score = 52.4 bits (124), Expect = 4e-07
 Identities = 34/107 (31%), Positives = 47/107 (43%), Gaps = 8/107 (7%)
 Frame = +2

Query: 302 PQVCGFISDRSVKEVACGGDHSVFLLEDGEVYTCGLNTKGQLGHEREGNKPEQIGALA-- 475
           P+   F     VK+ ACGG     L  +G V+  G    G+  +  E   PE I      
Sbjct: 333 PRCLPFSGVGQVKQAACGGTGCAVLNGEGHVFVWGYGILGKGPNLVETALPEMIPPTLFG 392

Query: 476 ------DEHIVHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTEE 598
                 +  +  + CG SH  AL+DRG+LF WG    G LG+   E+
Sbjct: 393 LTELNPEVRVSRIRCGLSHFAALTDRGELFVWGKNIRGCLGIGRLED 439


  Database: RefSeq49_SP.fasta
    Posted date:  Oct 17, 2011  1:42 PM
  Number of letters in database: 11,343,932
  Number of sequences in database:  24,897
  
Lambda     K      H
   0.318    0.134    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 24897
Number of Hits to DB: 32,086,624
Number of extensions: 1043656
Number of successful extensions: 5823
Number of sequences better than 1.0e-05: 21
Number of HSP's gapped: 5497
Number of HSP's successfully gapped: 108
Length of query: 351
Length of database: 11,343,932
Length adjustment: 100
Effective length of query: 251
Effective length of database: 8,854,232
Effective search space: 2222412232
Effective search space used: 2222412232
Neighboring words threshold: 12
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 34 (17.7 bits)

BLASTN 2.2.24 [Aug-08-2010]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= 20110601C-003003
         (1053 letters)

Database: Sscrofa_10.2.fasta 
           4582 sequences; 2,808,509,378 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

Sscrofa_Chr08                                                         521   e-145

>Sscrofa_Chr08 
||          Length = 148491826

 Score =  521 bits (263), Expect = e-145
 Identities = 266/267 (99%)
 Strand = Plus / Minus

                                                                             
Query: 189       gctgtcttctaggctgcatgactccctgaaggacgcaaaccatgttatgctggggatatt 248
                 |||||||||||||||||||||||||||||||||| |||||||||||||||||||||||||
Sbjct: 139868338 gctgtcttctaggctgcatgactccctgaaggacacaaaccatgttatgctggggatatt 139868279

                                                                             
Query: 249       ggtctctgggccagcctgggatcagcactaacctgcaggggatcgtggccgagcctcagg 308
                 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 139868278 ggtctctgggccagcctgggatcagcactaacctgcaggggatcgtggccgagcctcagg 139868219

                                                                             
Query: 309       tgtgtggattcatctcggaccgaagcgtcaaggaggtggcctgcggtggagaccactccg 368
                 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 139868218 tgtgtggattcatctcggaccgaagcgtcaaggaggtggcctgcggtggagaccactccg 139868159

                                                                             
Query: 369       tgttcctgctggaggatggcgaggtctacacctgcggtctgaacaccaaggggcagctgg 428
                 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 139868158 tgttcctgctggaggatggcgaggtctacacctgcggtctgaacaccaaggggcagctgg 139868099

                                            
Query: 429       gccacgagagggaaggaaacaagccag 455
                 |||||||||||||||||||||||||||
Sbjct: 139868098 gccacgagagggaaggaaacaagccag 139868072



 Score =  442 bits (223), Expect = e-121
 Identities = 223/223 (100%)
 Strand = Plus / Minus

                                                                             
Query: 692       gatggtcagttcttcacatggggcaagaacagccacgggcagctgggcctggggaaggag 751
                 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 139829551 gatggtcagttcttcacatggggcaagaacagccacgggcagctgggcctggggaaggag 139829492

                                                                             
Query: 752       ttcccctcccaagccagcccgcagagagtgaggtccctggagggcatcccgctggcgcag 811
                 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 139829491 ttcccctcccaagccagcccgcagagagtgaggtccctggagggcatcccgctggcgcag 139829432

                                                                             
Query: 812       gtggctgcaggaggggcccacagctttgccctgtctctctcaggagccgtttttggctgg 871
                 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 139829431 gtggctgcaggaggggcccacagctttgccctgtctctctcaggagccgtttttggctgg 139829372

                                                            
Query: 872       gggatgaataacgcagggcagctggggctcagtgacgaggaag 914
                 |||||||||||||||||||||||||||||||||||||||||||
Sbjct: 139829371 gggatgaataacgcagggcagctggggctcagtgacgaggaag 139829329



 Score =  329 bits (166), Expect = 2e-87
 Identities = 166/166 (100%)
 Strand = Plus / Minus

                                                                             
Query: 452       ccagagcaaattggagcattggcagatgagcacattgtccatgtggcgtgtggcgagtcc 511
                 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 139834595 ccagagcaaattggagcattggcagatgagcacattgtccatgtggcgtgtggcgagtcc 139834536

                                                                             
Query: 512       cacagcctggccctcagtgaccggggccagctgttttcttggggtgcaggcagcgatggt 571
                 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 139834535 cacagcctggccctcagtgaccggggccagctgttttcttggggtgcaggcagcgatggt 139834476

                                                               
Query: 572       cagctgggactcatgacgaccgaggagtcggtggcggtgcccaggt 617
                 ||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 139834475 cagctgggactcatgacgaccgaggagtcggtggcggtgcccaggt 139834430



 Score =  190 bits (96), Expect = 1e-45
 Identities = 96/96 (100%)
 Strand = Plus / Minus

                                                                             
Query: 913       agaccgagagtctccctgccatgtgaagctcctccgagcacaaaaagtcgtctatatcag 972
                 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 139828133 agaccgagagtctccctgccatgtgaagctcctccgagcacaaaaagtcgtctatatcag 139828074

                                                     
Query: 973       ctgtggagaagaacatacagccgttctcacaaaagt 1008
                 ||||||||||||||||||||||||||||||||||||
Sbjct: 139828073 ctgtggagaagaacatacagccgttctcacaaaagt 139828038



 Score =  157 bits (79), Expect = 1e-35
 Identities = 79/79 (100%)
 Strand = Plus / Minus

                                                                             
Query: 614       aggttaatacagaagctgaaccagcagacaatattacaagtttcctgtggcaactggcat 673
                 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 139830608 aggttaatacagaagctgaaccagcagacaatattacaagtttcctgtggcaactggcat 139830549

                                    
Query: 674       tgcttggctcttgcagctg 692
                 |||||||||||||||||||
Sbjct: 139830548 tgcttggctcttgcagctg 139830530



 Score =  111 bits (56), Expect = 8e-22
 Identities = 62/64 (96%)
 Strand = Plus / Minus

                                                                             
Query: 126       agatctgccacgcgaggcggaaccattctggcctgtagtgcagatgccgagtgcgtgacc 185
                 |||| |||||||||||||||| ||||||||||||||||||||||||||||||||||||||
Sbjct: 139878254 agatttgccacgcgaggcggacccattctggcctgtagtgcagatgccgagtgcgtgacc 139878195

                     
Query: 186       tgtg 189
                 ||||
Sbjct: 139878194 tgtg 139878191



 Score = 87.7 bits (44), Expect = 1e-14
 Identities = 47/48 (97%)
 Strand = Plus / Minus

                                                                 
Query: 1006      agtggaggtgtgtttacctttggtgctggttcctgcgggccacttggc 1053
                 |||||||||||||||||||||||||||||||||||||||| |||||||
Sbjct: 139827014 agtggaggtgtgtttacctttggtgctggttcctgcgggcaacttggc 139826967


  Database: Sscrofa_10.2.fasta
    Posted date:  Nov 16, 2011 10:34 AM
  Number of letters in database: 2,808,509,378
  Number of sequences in database:  4582
  
Lambda     K      H
    1.37    0.711     1.31 

Gapped
Lambda     K      H
    1.37    0.711     1.31 


Matrix: blastn matrix:1 -3
Gap Penalties: Existence: 5, Extension: 2
Number of Sequences: 4582
Number of Hits to DB: 28,075,906
Number of extensions: 147
Number of successful extensions: 147
Number of sequences better than 1.0e-05: 1
Number of HSP's gapped: 147
Number of HSP's successfully gapped: 7
Length of query: 1053
Length of database: 2,808,509,378
Length adjustment: 21
Effective length of query: 1032
Effective length of database: 2,808,413,156
Effective search space: 2898282376992
Effective search space used: 2898282376992
X1: 11 (21.8 bits)
X2: 15 (29.7 bits)
X3: 50 (99.1 bits)
S1: 18 (36.2 bits)
S2: 30 (60.0 bits)