Animal-Genome cDNA 20110601C-003115

BLASTX 2.2.24 [Aug-08-2010]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= 20110601C-003115
         (3506 letters)

Database: RefSeq49_BP.fasta 
           33,088 sequences; 17,681,374 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

Alignment   gi|NP_001193010.1| probable E3 ubiquitin-protein ligase HERC2 [...   650   0.0  
Alignment   gi|XP_002685237.1| PREDICTED: hect domain and RLD 3-like [Bos t...   650   0.0  
Alignment   gi|NP_001092431.1| probable E3 ubiquitin-protein ligase HECTD3 ...   192   2e-48
Alignment   gi|NP_001077132.1| probable E3 ubiquitin-protein ligase HERC3 [...   176   2e-43
Alignment   gi|NP_001070362.2| hect domain and RLD 4 [Bos taurus].               160   7e-39
Alignment   gi|NP_001179573.1| probable E3 ubiquitin-protein ligase HERC6 [...   156   1e-37
Alignment   gi|XP_002688230.1| PREDICTED: hect domain and RLD 6-like isofor...   156   1e-37
Alignment   gi|XP_002688229.1| PREDICTED: hect domain and RLD 6-like isofor...   156   1e-37
Alignment   gi|XP_002704581.1| PREDICTED: hect domain and RLD 6 isoform 1 [...   156   1e-37
Alignment   gi|NP_001179920.1| RCC1 and BTB domain-containing protein 2 [Bo...   152   2e-36

>ref|NP_001193010.1| probable E3 ubiquitin-protein ligase HERC2 [Bos taurus].
          Length = 4837

 Score =  650 bits (1676), Expect = 0.0
 Identities = 392/1007 (38%), Positives = 548/1007 (54%), Gaps = 29/1007 (2%)
 Frame = +2

Query: 2    EKPHVVCGDQLVHSPYMQCLASLAVGLHLDQLLCNPPVPPHHQNCLPDPASWNPNEWAWL 181
            E P V  G QL+HSP+ + L +LA  L LD L C          C         ++WAW 
Sbjct: 3834 EDPIVRGGKQLLHSPFFKVLVALACDLELDTLPC----------CA------ETHKWAWF 3877

Query: 182  ECFSTTIKAAEALTNGAQFPESF------SVPDLEPVPEDELVFLMDNSKWINGMDEQIM 343
              +    + A AL      P  F       + +L    E+  V    +S +    DEQ++
Sbjct: 3878 RRYCMASRVAVALDKRTSLPRLFLDEVAKKIRELMADGENMDVLHESHSIFRREQDEQLV 3937

Query: 344  SWATSRPEDWHL--GGKCDVYLWGAGRHGQLAEA-GRNVMVXXXXXXXXXXXXV--ICGQ 508
             W   RP+DW L  GG   +Y WG    GQL    G  V V            V  I G+
Sbjct: 3938 QWMNRRPDDWTLSAGGSGTIYGWGHNHRGQLGGIEGAKVKVPTPCEALAALRPVQLIGGE 3997

Query: 509  NCTFVIQANGTVLACGEGSYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSDGHSMA 688
               F + A+G + A G G+ GRLG G ++ +   T++ ++Q   + ++  + G   H +A
Sbjct: 3998 QTLFAVTADGKLYATGYGAGGRLGVGGTESVSTPTLLESIQHVFIKKVAVNSGGK-HCLA 4056

Query: 689  LTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLF 868
            L+  GEV+SWG+ + GKLGHGN     RPR IE+L+G EVV ++ G  HSA VT+ G L+
Sbjct: 4057 LSSEGEVYSWGEAEDGKLGHGNRSPCDRPRVIESLRGTEVVDVAAGGAHSACVTAAGDLY 4116

Query: 869  TFGNGDYGRLGLGNTSNKKLPERVTALEGYQIGQVACGLN--HTLAVSADGSMVWAFGDG 1042
            T+G G YGRLG  ++ ++  P+ V AL+G+++  VACG     TL ++ D + VW++GDG
Sbjct: 4117 TWGKGRYGRLGHSDSEDQLKPKLVEALQGHRVVDVACGSGDAQTLCLTDDDT-VWSWGDG 4175

Query: 1043 DYGKLGLGNSTAKSSPQKVDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGLPEG 1222
            DYGKLG G S     P K+D L G+G+ KV CG+QFSVALTK G VYT+G+     L  G
Sbjct: 4176 DYGKLGRGGSDGCKVPMKIDSLTGLGVVKVECGSQFSVALTKSGAVYTWGKGDYHRLGHG 4235

Query: 1223 RARNHNRPQQIPVLAGVVIEDVAVGAEHTLALASTGDVYAWGSNSEGQLGLGHTNHVREP 1402
               +  RP+Q+  L G  +  +A G+ H +  +  G+VY WG N EGQLG G TN ++ P
Sbjct: 4236 SDDHVRRPRQVQGLQGKKVIAIATGSLHCVCCSEDGEVYTWGDNDEGQLGDGTTNAIQRP 4295

Query: 1403 TLVTVLQGKNVRQISAGRCHSAAWTAPPVPPRAPGVSVPLQLG-LPDAVPPQYGALREVS 1579
             LV  LQGK V +++ G  H+ AW+           S P   G LP  VP +Y  L+E+ 
Sbjct: 4296 RLVAALQGKKVNRVACGSAHTLAWS----------TSKPASAGKLPVQVPMEYNHLQEIP 4345

Query: 1580 IHTARARLRLLYHFSDLMYSSWRLLNLSPNNQNSTSHYNAGTWGIVQGQLRPLLAPRVYT 1759
            I   R RL LL+H S+L      + +L    + S      G   +    LR +L  +   
Sbjct: 4346 IIALRNRLLLLHHISELFCPCIPMFDL----EGSLDETGLGP-SVGFDTLRGILISQGKE 4400

Query: 1760 LPMVRSIGKTMVQGKNYGPQITVKRISTRGRK----------CKPIFVQIARQVVKLNAS 1909
                + +  TMV+ + +GP + + RI  +  +           K +F Q+  ++   +  
Sbjct: 4401 AAFRKVVQATMVRDRQHGPVVELNRIQVKRSRSKGGLAGPDGTKSVFGQMCAKMTSFSPD 4460

Query: 1910 DLRLPSRAWKVKLVGEGADDAGGVFDDTITEMCQELETGIVDLLIPSPNATAEVGYNRDR 2089
             L LP R WKVK VGE  DD GG + ++I E+C+EL+ G+  LLI +PN   E G NRD 
Sbjct: 4461 SLLLPHRVWKVKFVGESVDDCGGGYSESIAEICEELQNGLTPLLIVTPNGRDESGANRDC 4520

Query: 2090 FLFNPSACLDEHLMQFKFLGILMGVAIRTKKPLDLHLAPLVWKQLCCVPXXXXXXXXXXX 2269
            +LF+P+A    H   F+FLG+L+G+AIRT  PL L+LA  VWKQL  +            
Sbjct: 4521 YLFSPAARAPVHTNMFRFLGVLLGIAIRTGSPLSLNLAEPVWKQLAGMSLTIADLSEVDK 4580

Query: 2270 XYVQTLNSILHIEDSGITEESFHEM-IPLDSFVGQSADGKMVPIIPGGNSIPLTFSNRKE 2446
             ++     +++I D+  T E F  M +P   F   SA G+ + +        +T  NR E
Sbjct: 4581 DFIP---GLMYIRDNEATSEEFEAMSLP---FTVPSASGQDIQL--SSKYTHITLDNRAE 4632

Query: 2447 YVERAIEYRLHEMDRQVAAVREGMSWIVPVPLLSLLTAKQLEQMVCGMPEISVEVLKKVV 2626
            YV  AI YRLHE D QVAAVREGM+ +VPVPLLSL T  +LE MVCG P+I + +LK V 
Sbjct: 4633 YVRLAINYRLHEFDEQVAAVREGMARVVPVPLLSLFTGYELETMVCGSPDIPLHLLKSVA 4692

Query: 2627 RYREVDEQHQLVQWFWHTLEEFSNEERVLFMRFVSGRSRLPANTADISQR-FQIMKVDR- 2800
             Y+ V+    L+QWFW  +E FSN ER LF+RFV GR+RLP   AD   R F I  +D+ 
Sbjct: 4693 TYKGVEPSAPLIQWFWEVMESFSNTERSLFLRFVWGRTRLPRTIADFRGRDFVIQVLDKY 4752

Query: 2801 --PYDSLPTSQTCFFQLRLPPYSSQLVMAERLRYAINNCRSIDMDNY 2935
              P   LP S TCFF L+LP YS + V+ E+L+YAI+ C+SID D+Y
Sbjct: 4753 NPPDHFLPESYTCFFLLKLPRYSCKQVLEEKLKYAIHFCKSIDTDDY 4799



 Score =  263 bits (672), Expect = 8e-70
 Identities = 147/343 (42%), Positives = 208/343 (60%), Gaps = 3/343 (0%)
 Frame = +2

Query: 503  GQNCTFVIQANGTVLACGEGSYGRLGQG-NSDDLHVLTVISALQGFVVTQLVTSCGSDGH 679
            G    F +   G V ACGE + GRLG G +S  + +   I+AL  +VV ++    G   H
Sbjct: 3001 GSKSLFAVTVEGKVYACGEATNGRLGLGISSGTVPIPRQITALSSYVVKKVAVHSGGR-H 3059

Query: 680  SMALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDG 859
            + ALT  G+VFSWG+GD GKLGH +     +PR IEAL+ + +  ++CG  HSA +TS G
Sbjct: 3060 ATALTVDGKVFSWGEGDDGKLGHFSRMNCDKPRLIEALKTKRIRDIACGSSHSAALTSSG 3119

Query: 860  KLFTFGNGDYGRLGLGNTSNKKLPERVTALEGYQIGQVACGLN--HTLAVSADGSMVWAF 1033
            +L+T+G G+YGRLG G+ + +  P+ V  L G+++ QVACG     TLA++ +G +V+++
Sbjct: 3120 ELYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEG-LVFSW 3178

Query: 1034 GDGDYGKLGLGNSTAKSSPQKVDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGL 1213
            GDGD+GKLG G S   + PQ ++ L G G+ ++ CG QFS+ALTK G V+T+G+     L
Sbjct: 3179 GDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFSLALTKSGVVWTWGKGDYFRL 3238

Query: 1214 PEGRARNHNRPQQIPVLAGVVIEDVAVGAEHTLALASTGDVYAWGSNSEGQLGLGHTNHV 1393
              G   +  +PQ +  L G  I  VAVGA H LA+   G VYAWG N  GQ G G T   
Sbjct: 3239 GHGSDVHVRKPQVVEGLRGKKIVHVAVGALHCLAVTDAGQVYAWGDNDHGQQGNGTTTVN 3298

Query: 1394 REPTLVTVLQGKNVRQISAGRCHSAAWTAPPVPPRAPGVSVPL 1522
            R+PTLV  L+G+ + +++ G  HS AWT   V    P V  P+
Sbjct: 3299 RKPTLVQGLEGQKITRVACGSSHSVAWTT--VDVATPSVHEPV 3339



 Score =  210 bits (535), Expect = 6e-54
 Identities = 130/343 (37%), Positives = 195/343 (56%), Gaps = 20/343 (5%)
 Frame = +2

Query: 512  CTFVIQANGTVLACGEGSYGRLGQG--------NSDDLHVLTVISALQGFVVTQLVT-SC 664
            C  +     T +AC E  +  L +         NSD L    V    QG     +V  + 
Sbjct: 446  CEGLANLGVTQIACAEKRFLILSRNGRVYTQAYNSDTLAPQLV----QGLASRNIVKIAA 501

Query: 665  GSDGHS-MALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEE----VVQMSCGF 829
             SDGH  +AL  +GEV+SWG GD G+LGHG++     P+ I A  G++    VV ++CG 
Sbjct: 502  HSDGHHYLALAATGEVYSWGCGDGGRLGHGDTVPLEEPKVISAFSGKQAGKHVVHIACGS 561

Query: 830  KHSAVVTSDGKLFTFGNGDYGRLGLGNTSNKKLPERVTALEGYQIGQVACGLN--HTLAV 1003
             +SA +T++G+L+T+G G+YGRLG G++ ++ +P  V  L+G ++  VACG     TLAV
Sbjct: 562  TYSAAITAEGELYTWGRGNYGRLGHGSSEDEAIPMLVAGLKGLKVIDVACGSGDAQTLAV 621

Query: 1004 SADGSMVWAFGDGDYGKLGLGNSTAKSSPQKVDVLCGIGIKKVACGTQFSVALTKDGHVY 1183
            + +G  VW++GDGDYGKLG G S    +P+ ++ L  + + KV CG+QFSVALTKDG VY
Sbjct: 622  TENGQ-VWSWGDGDYGKLGRGGSDGCKTPKLIEKLQDLDVVKVRCGSQFSVALTKDGQVY 680

Query: 1184 TFGQDRLIGLPEGRARNHNRPQQIPVLAGVVIEDVAVGAEHTLALASTGDVYAWGSNSEG 1363
            ++G+     L  G   +   P+ +  L G  + DVA G+ H LAL    +V++WGSN + 
Sbjct: 681  SWGKGDNQRLGHGTEEHVRYPKLLEGLQGKKVIDVAAGSTHCLALTEDSEVHSWGSNDQC 740

Query: 1364 QLGLGHTNHVR----EPTLVTVLQGKNVRQISAGRCHSAAWTA 1480
            Q    H + +R    EP+ +  L  K++  I+ G   S AW++
Sbjct: 741  Q----HFDTLRVTKPEPSALPGLDTKHIVGIACGPAQSFAWSS 779



 Score =  166 bits (421), Expect = 1e-40
 Identities = 100/261 (38%), Positives = 142/261 (54%), Gaps = 4/261 (1%)
 Frame = +2

Query: 395  VYLWGAGRHGQLAEAGR---NVMVXXXXXXXXXXXXVICGQNCTFVIQANGTVLACGEGS 565
            V+ WG G  G+L    R   +               + CG + +  + ++G +   G G 
Sbjct: 3069 VFSWGEGDDGKLGHFSRMNCDKPRLIEALKTKRIRDIACGSSHSAALTSSGELYTWGLGE 3128

Query: 566  YGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGS-DGHSMALTESGEVFSWGDGDYGKL 742
            YGRLG G++       ++  L G  V Q+  +CGS D  ++ALT+ G VFSWGDGD+GKL
Sbjct: 3129 YGRLGHGDNTTQLKPKMVKVLLGHRVIQV--ACGSRDAQTLALTDEGLVFSWGDGDFGKL 3186

Query: 743  GHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLGLGNTSNK 922
            G G S+    P+ IE L G+ V Q+ CG + S  +T  G ++T+G GDY RLG G+  + 
Sbjct: 3187 GRGGSEGCNIPQNIERLNGQGVCQIECGAQFSLALTKSGVVWTWGKGDYFRLGHGSDVHV 3246

Query: 923  KLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNSTAKSSPQKVD 1102
            + P+ V  L G +I  VA G  H LAV+ D   V+A+GD D+G+ G G +T    P  V 
Sbjct: 3247 RKPQVVEGLRGKKIVHVAVGALHCLAVT-DAGQVYAWGDNDHGQQGNGTTTVNRKPTLVQ 3305

Query: 1103 VLCGIGIKKVACGTQFSVALT 1165
             L G  I +VACG+  SVA T
Sbjct: 3306 GLEGQKITRVACGSSHSVAWT 3326



 Score =  159 bits (402), Expect = 2e-38
 Identities = 117/399 (29%), Positives = 187/399 (46%), Gaps = 34/399 (8%)
 Frame = +2

Query: 65   SLAVGLHLDQLL--CNPPV---PPHHQNCLPDPASWNPNEWAW-------LECFS----- 193
            ++ V  HLD+L   C PP+   P  H+  L +   W    W +       ++C       
Sbjct: 394  AVVVMAHLDRLATPCMPPLCSSPTSHKGSLQEVIGWGLIGWKYYANVIGPIQCEGLANLG 453

Query: 194  -TTIKAAEAL-----TNGAQFPESFSVPDLEPVPEDELVFLMDNSKWINGMDEQIMSWAT 355
             T I  AE        NG  + ++++   L P             + + G+  + +    
Sbjct: 454  VTQIACAEKRFLILSRNGRVYTQAYNSDTLAP-------------QLVQGLASRNIVKIA 500

Query: 356  SRPEDWH---LGGKCDVYLWGAGRHGQLA-------EAGRNVMVXXXXXXXXXXXXVICG 505
            +  +  H   L    +VY WG G  G+L        E  + +              + CG
Sbjct: 501  AHSDGHHYLALAATGEVYSWGCGDGGRLGHGDTVPLEEPKVISAFSGKQAGKHVVHIACG 560

Query: 506  QNCTFVIQANGTVLACGEGSYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGS-DGHS 682
               +  I A G +   G G+YGRLG G+S+D  +  +++ L+G  V  +  +CGS D  +
Sbjct: 561  STYSAAITAEGELYTWGRGNYGRLGHGSSEDEAIPMLVAGLKGLKVIDV--ACGSGDAQT 618

Query: 683  MALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGK 862
            +A+TE+G+V+SWGDGDYGKLG G SD  + P+ IE LQ  +VV++ CG + S  +T DG+
Sbjct: 619  LAVTENGQVWSWGDGDYGKLGRGGSDGCKTPKLIEKLQDLDVVKVRCGSQFSVALTKDGQ 678

Query: 863  LFTFGNGDYGRLGLGNTSNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDG 1042
            ++++G GD  RLG G   + + P+ +  L+G ++  VA G  H LA++ D S V ++G  
Sbjct: 679  VYSWGKGDNQRLGHGTEEHVRYPKLLEGLQGKKVIDVAAGSTHCLALTED-SEVHSWGSN 737

Query: 1043 DYGKLGLGNSTAKSSPQKVDVLCGIGIKKVACGTQFSVA 1159
            D  +        K  P  +  L    I  +ACG   S A
Sbjct: 738  DQCQHFDTLRVTKPEPSALPGLDTKHIVGIACGPAQSFA 776



 Score =  138 bits (347), Expect = 4e-32
 Identities = 95/273 (34%), Positives = 136/273 (49%), Gaps = 5/273 (1%)
 Frame = +2

Query: 674  GHSMALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTS 853
            G   A T   +VF WG  D  +LG     + + P   E L    VVQ++ G K    VT 
Sbjct: 2951 GLESAATIRTKVFVWGLNDKDQLGGLKGSKIKVPSFSETLSALNVVQVAGGSKSLFAVTV 3010

Query: 854  DGKLFTFGNGDYGRLGLGNTSNK-KLPERVTALEGYQIGQVA--CGLNHTLAVSADGSMV 1024
            +GK++  G    GRLGLG +S    +P ++TAL  Y + +VA   G  H  A++ DG  V
Sbjct: 3011 EGKVYACGEATNGRLGLGISSGTVPIPRQITALSSYVVKKVAVHSGGRHATALTVDGK-V 3069

Query: 1025 WAFGDGDYGKLGLGNSTAKSSPQKVDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRL 1204
            +++G+GD GKLG  +      P+ ++ L    I+ +ACG+  S ALT  G +YT+G    
Sbjct: 3070 FSWGEGDDGKLGHFSRMNCDKPRLIEALKTKRIRDIACGSSHSAALTSSGELYTWGLGEY 3129

Query: 1205 IGLPEGRARNHNRPQQIPVLAGVVIEDVAVGAE--HTLALASTGDVYAWGSNSEGQLGLG 1378
              L  G      +P+ + VL G  +  VA G+    TLAL   G V++WG    G+LG G
Sbjct: 3130 GRLGHGDNTTQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFSWGDGDFGKLGRG 3189

Query: 1379 HTNHVREPTLVTVLQGKNVRQISAGRCHSAAWT 1477
             +     P  +  L G+ V QI  G   S A T
Sbjct: 3190 GSEGCNIPQNIERLNGQGVCQIECGAQFSLALT 3222



 Score = 68.6 bits (166), Expect = 4e-11
 Identities = 46/139 (33%), Positives = 73/139 (52%), Gaps = 8/139 (5%)
 Frame = +2

Query: 1088 PQKVDVLCGIGIKKVACGTQFSVALTKDGHVYT--FGQDRLIGLPEGRARNHNRPQQIPV 1261
            P + + L  +G+ ++AC  +  + L+++G VYT  +  D L             PQ +  
Sbjct: 443  PIQCEGLANLGVTQIACAEKRFLILSRNGRVYTQAYNSDTL------------APQLVQG 490

Query: 1262 LAGVVIEDVAVGAE--HTLALASTGDVYAWGSNSEGQLGLGHTNHVREPTLVTVLQ---- 1423
            LA   I  +A  ++  H LALA+TG+VY+WG    G+LG G T  + EP +++       
Sbjct: 491  LASRNIVKIAAHSDGHHYLALAATGEVYSWGCGDGGRLGHGDTVPLEEPKVISAFSGKQA 550

Query: 1424 GKNVRQISAGRCHSAAWTA 1480
            GK+V  I+ G  +SAA TA
Sbjct: 551  GKHVVHIACGSTYSAAITA 569


>ref|XP_002685237.1| PREDICTED: hect domain and RLD 3-like [Bos taurus].
          Length = 4837

 Score =  650 bits (1676), Expect = 0.0
 Identities = 392/1007 (38%), Positives = 548/1007 (54%), Gaps = 29/1007 (2%)
 Frame = +2

Query: 2    EKPHVVCGDQLVHSPYMQCLASLAVGLHLDQLLCNPPVPPHHQNCLPDPASWNPNEWAWL 181
            E P V  G QL+HSP+ + L +LA  L LD L C          C         ++WAW 
Sbjct: 3834 EDPIVRGGKQLLHSPFFKVLVALACDLELDTLPC----------CA------ETHKWAWF 3877

Query: 182  ECFSTTIKAAEALTNGAQFPESF------SVPDLEPVPEDELVFLMDNSKWINGMDEQIM 343
              +    + A AL      P  F       + +L    E+  V    +S +    DEQ++
Sbjct: 3878 RRYCMASRVAVALDKRTSLPRLFLDEVAKKIRELMADGENMDVLHESHSIFRREQDEQLV 3937

Query: 344  SWATSRPEDWHL--GGKCDVYLWGAGRHGQLAEA-GRNVMVXXXXXXXXXXXXV--ICGQ 508
             W   RP+DW L  GG   +Y WG    GQL    G  V V            V  I G+
Sbjct: 3938 QWMNRRPDDWTLSAGGSGTIYGWGHNHRGQLGGIEGAKVKVPTPCEALAALRPVQLIGGE 3997

Query: 509  NCTFVIQANGTVLACGEGSYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSDGHSMA 688
               F + A+G + A G G+ GRLG G ++ +   T++ ++Q   + ++  + G   H +A
Sbjct: 3998 QTLFAVTADGKLYATGYGAGGRLGVGGTESVSTPTLLESIQHVFIKKVAVNSGGK-HCLA 4056

Query: 689  LTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLF 868
            L+  GEV+SWG+ + GKLGHGN     RPR IE+L+G EVV ++ G  HSA VT+ G L+
Sbjct: 4057 LSSEGEVYSWGEAEDGKLGHGNRSPCDRPRVIESLRGTEVVDVAAGGAHSACVTAAGDLY 4116

Query: 869  TFGNGDYGRLGLGNTSNKKLPERVTALEGYQIGQVACGLN--HTLAVSADGSMVWAFGDG 1042
            T+G G YGRLG  ++ ++  P+ V AL+G+++  VACG     TL ++ D + VW++GDG
Sbjct: 4117 TWGKGRYGRLGHSDSEDQLKPKLVEALQGHRVVDVACGSGDAQTLCLTDDDT-VWSWGDG 4175

Query: 1043 DYGKLGLGNSTAKSSPQKVDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGLPEG 1222
            DYGKLG G S     P K+D L G+G+ KV CG+QFSVALTK G VYT+G+     L  G
Sbjct: 4176 DYGKLGRGGSDGCKVPMKIDSLTGLGVVKVECGSQFSVALTKSGAVYTWGKGDYHRLGHG 4235

Query: 1223 RARNHNRPQQIPVLAGVVIEDVAVGAEHTLALASTGDVYAWGSNSEGQLGLGHTNHVREP 1402
               +  RP+Q+  L G  +  +A G+ H +  +  G+VY WG N EGQLG G TN ++ P
Sbjct: 4236 SDDHVRRPRQVQGLQGKKVIAIATGSLHCVCCSEDGEVYTWGDNDEGQLGDGTTNAIQRP 4295

Query: 1403 TLVTVLQGKNVRQISAGRCHSAAWTAPPVPPRAPGVSVPLQLG-LPDAVPPQYGALREVS 1579
             LV  LQGK V +++ G  H+ AW+           S P   G LP  VP +Y  L+E+ 
Sbjct: 4296 RLVAALQGKKVNRVACGSAHTLAWS----------TSKPASAGKLPVQVPMEYNHLQEIP 4345

Query: 1580 IHTARARLRLLYHFSDLMYSSWRLLNLSPNNQNSTSHYNAGTWGIVQGQLRPLLAPRVYT 1759
            I   R RL LL+H S+L      + +L    + S      G   +    LR +L  +   
Sbjct: 4346 IIALRNRLLLLHHISELFCPCIPMFDL----EGSLDETGLGP-SVGFDTLRGILISQGKE 4400

Query: 1760 LPMVRSIGKTMVQGKNYGPQITVKRISTRGRK----------CKPIFVQIARQVVKLNAS 1909
                + +  TMV+ + +GP + + RI  +  +           K +F Q+  ++   +  
Sbjct: 4401 AAFRKVVQATMVRDRQHGPVVELNRIQVKRSRSKGGLAGPDGTKSVFGQMCAKMTSFSPD 4460

Query: 1910 DLRLPSRAWKVKLVGEGADDAGGVFDDTITEMCQELETGIVDLLIPSPNATAEVGYNRDR 2089
             L LP R WKVK VGE  DD GG + ++I E+C+EL+ G+  LLI +PN   E G NRD 
Sbjct: 4461 SLLLPHRVWKVKFVGESVDDCGGGYSESIAEICEELQNGLTPLLIVTPNGRDESGANRDC 4520

Query: 2090 FLFNPSACLDEHLMQFKFLGILMGVAIRTKKPLDLHLAPLVWKQLCCVPXXXXXXXXXXX 2269
            +LF+P+A    H   F+FLG+L+G+AIRT  PL L+LA  VWKQL  +            
Sbjct: 4521 YLFSPAARAPVHTNMFRFLGVLLGIAIRTGSPLSLNLAEPVWKQLAGMSLTIADLSEVDK 4580

Query: 2270 XYVQTLNSILHIEDSGITEESFHEM-IPLDSFVGQSADGKMVPIIPGGNSIPLTFSNRKE 2446
             ++     +++I D+  T E F  M +P   F   SA G+ + +        +T  NR E
Sbjct: 4581 DFIP---GLMYIRDNEATSEEFEAMSLP---FTVPSASGQDIQL--SSKYTHITLDNRAE 4632

Query: 2447 YVERAIEYRLHEMDRQVAAVREGMSWIVPVPLLSLLTAKQLEQMVCGMPEISVEVLKKVV 2626
            YV  AI YRLHE D QVAAVREGM+ +VPVPLLSL T  +LE MVCG P+I + +LK V 
Sbjct: 4633 YVRLAINYRLHEFDEQVAAVREGMARVVPVPLLSLFTGYELETMVCGSPDIPLHLLKSVA 4692

Query: 2627 RYREVDEQHQLVQWFWHTLEEFSNEERVLFMRFVSGRSRLPANTADISQR-FQIMKVDR- 2800
             Y+ V+    L+QWFW  +E FSN ER LF+RFV GR+RLP   AD   R F I  +D+ 
Sbjct: 4693 TYKGVEPSAPLIQWFWEVMESFSNTERSLFLRFVWGRTRLPRTIADFRGRDFVIQVLDKY 4752

Query: 2801 --PYDSLPTSQTCFFQLRLPPYSSQLVMAERLRYAINNCRSIDMDNY 2935
              P   LP S TCFF L+LP YS + V+ E+L+YAI+ C+SID D+Y
Sbjct: 4753 NPPDHFLPESYTCFFLLKLPRYSCKQVLEEKLKYAIHFCKSIDTDDY 4799



 Score =  263 bits (672), Expect = 8e-70
 Identities = 147/343 (42%), Positives = 208/343 (60%), Gaps = 3/343 (0%)
 Frame = +2

Query: 503  GQNCTFVIQANGTVLACGEGSYGRLGQG-NSDDLHVLTVISALQGFVVTQLVTSCGSDGH 679
            G    F +   G V ACGE + GRLG G +S  + +   I+AL  +VV ++    G   H
Sbjct: 3001 GSKSLFAVTVEGKVYACGEATNGRLGLGISSGTVPIPRQITALSSYVVKKVAVHSGGR-H 3059

Query: 680  SMALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDG 859
            + ALT  G+VFSWG+GD GKLGH +     +PR IEAL+ + +  ++CG  HSA +TS G
Sbjct: 3060 ATALTVDGKVFSWGEGDDGKLGHFSRMNCDKPRLIEALKTKRIRDIACGSSHSAALTSSG 3119

Query: 860  KLFTFGNGDYGRLGLGNTSNKKLPERVTALEGYQIGQVACGLN--HTLAVSADGSMVWAF 1033
            +L+T+G G+YGRLG G+ + +  P+ V  L G+++ QVACG     TLA++ +G +V+++
Sbjct: 3120 ELYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEG-LVFSW 3178

Query: 1034 GDGDYGKLGLGNSTAKSSPQKVDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGL 1213
            GDGD+GKLG G S   + PQ ++ L G G+ ++ CG QFS+ALTK G V+T+G+     L
Sbjct: 3179 GDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFSLALTKSGVVWTWGKGDYFRL 3238

Query: 1214 PEGRARNHNRPQQIPVLAGVVIEDVAVGAEHTLALASTGDVYAWGSNSEGQLGLGHTNHV 1393
              G   +  +PQ +  L G  I  VAVGA H LA+   G VYAWG N  GQ G G T   
Sbjct: 3239 GHGSDVHVRKPQVVEGLRGKKIVHVAVGALHCLAVTDAGQVYAWGDNDHGQQGNGTTTVN 3298

Query: 1394 REPTLVTVLQGKNVRQISAGRCHSAAWTAPPVPPRAPGVSVPL 1522
            R+PTLV  L+G+ + +++ G  HS AWT   V    P V  P+
Sbjct: 3299 RKPTLVQGLEGQKITRVACGSSHSVAWTT--VDVATPSVHEPV 3339



 Score =  210 bits (535), Expect = 6e-54
 Identities = 130/343 (37%), Positives = 195/343 (56%), Gaps = 20/343 (5%)
 Frame = +2

Query: 512  CTFVIQANGTVLACGEGSYGRLGQG--------NSDDLHVLTVISALQGFVVTQLVT-SC 664
            C  +     T +AC E  +  L +         NSD L    V    QG     +V  + 
Sbjct: 446  CEGLANLGVTQIACAEKRFLILSRNGRVYTQAYNSDTLAPQLV----QGLASRNIVKIAA 501

Query: 665  GSDGHS-MALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEE----VVQMSCGF 829
             SDGH  +AL  +GEV+SWG GD G+LGHG++     P+ I A  G++    VV ++CG 
Sbjct: 502  HSDGHHYLALAATGEVYSWGCGDGGRLGHGDTVPLEEPKVISAFSGKQAGKHVVHIACGS 561

Query: 830  KHSAVVTSDGKLFTFGNGDYGRLGLGNTSNKKLPERVTALEGYQIGQVACGLN--HTLAV 1003
             +SA +T++G+L+T+G G+YGRLG G++ ++ +P  V  L+G ++  VACG     TLAV
Sbjct: 562  TYSAAITAEGELYTWGRGNYGRLGHGSSEDEAIPMLVAGLKGLKVIDVACGSGDAQTLAV 621

Query: 1004 SADGSMVWAFGDGDYGKLGLGNSTAKSSPQKVDVLCGIGIKKVACGTQFSVALTKDGHVY 1183
            + +G  VW++GDGDYGKLG G S    +P+ ++ L  + + KV CG+QFSVALTKDG VY
Sbjct: 622  TENGQ-VWSWGDGDYGKLGRGGSDGCKTPKLIEKLQDLDVVKVRCGSQFSVALTKDGQVY 680

Query: 1184 TFGQDRLIGLPEGRARNHNRPQQIPVLAGVVIEDVAVGAEHTLALASTGDVYAWGSNSEG 1363
            ++G+     L  G   +   P+ +  L G  + DVA G+ H LAL    +V++WGSN + 
Sbjct: 681  SWGKGDNQRLGHGTEEHVRYPKLLEGLQGKKVIDVAAGSTHCLALTEDSEVHSWGSNDQC 740

Query: 1364 QLGLGHTNHVR----EPTLVTVLQGKNVRQISAGRCHSAAWTA 1480
            Q    H + +R    EP+ +  L  K++  I+ G   S AW++
Sbjct: 741  Q----HFDTLRVTKPEPSALPGLDTKHIVGIACGPAQSFAWSS 779



 Score =  166 bits (421), Expect = 1e-40
 Identities = 100/261 (38%), Positives = 142/261 (54%), Gaps = 4/261 (1%)
 Frame = +2

Query: 395  VYLWGAGRHGQLAEAGR---NVMVXXXXXXXXXXXXVICGQNCTFVIQANGTVLACGEGS 565
            V+ WG G  G+L    R   +               + CG + +  + ++G +   G G 
Sbjct: 3069 VFSWGEGDDGKLGHFSRMNCDKPRLIEALKTKRIRDIACGSSHSAALTSSGELYTWGLGE 3128

Query: 566  YGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGS-DGHSMALTESGEVFSWGDGDYGKL 742
            YGRLG G++       ++  L G  V Q+  +CGS D  ++ALT+ G VFSWGDGD+GKL
Sbjct: 3129 YGRLGHGDNTTQLKPKMVKVLLGHRVIQV--ACGSRDAQTLALTDEGLVFSWGDGDFGKL 3186

Query: 743  GHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLGLGNTSNK 922
            G G S+    P+ IE L G+ V Q+ CG + S  +T  G ++T+G GDY RLG G+  + 
Sbjct: 3187 GRGGSEGCNIPQNIERLNGQGVCQIECGAQFSLALTKSGVVWTWGKGDYFRLGHGSDVHV 3246

Query: 923  KLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNSTAKSSPQKVD 1102
            + P+ V  L G +I  VA G  H LAV+ D   V+A+GD D+G+ G G +T    P  V 
Sbjct: 3247 RKPQVVEGLRGKKIVHVAVGALHCLAVT-DAGQVYAWGDNDHGQQGNGTTTVNRKPTLVQ 3305

Query: 1103 VLCGIGIKKVACGTQFSVALT 1165
             L G  I +VACG+  SVA T
Sbjct: 3306 GLEGQKITRVACGSSHSVAWT 3326



 Score =  159 bits (402), Expect = 2e-38
 Identities = 117/399 (29%), Positives = 187/399 (46%), Gaps = 34/399 (8%)
 Frame = +2

Query: 65   SLAVGLHLDQLL--CNPPV---PPHHQNCLPDPASWNPNEWAW-------LECFS----- 193
            ++ V  HLD+L   C PP+   P  H+  L +   W    W +       ++C       
Sbjct: 394  AVVVMAHLDRLATPCMPPLCSSPTSHKGSLQEVIGWGLIGWKYYANVIGPIQCEGLANLG 453

Query: 194  -TTIKAAEAL-----TNGAQFPESFSVPDLEPVPEDELVFLMDNSKWINGMDEQIMSWAT 355
             T I  AE        NG  + ++++   L P             + + G+  + +    
Sbjct: 454  VTQIACAEKRFLILSRNGRVYTQAYNSDTLAP-------------QLVQGLASRNIVKIA 500

Query: 356  SRPEDWH---LGGKCDVYLWGAGRHGQLA-------EAGRNVMVXXXXXXXXXXXXVICG 505
            +  +  H   L    +VY WG G  G+L        E  + +              + CG
Sbjct: 501  AHSDGHHYLALAATGEVYSWGCGDGGRLGHGDTVPLEEPKVISAFSGKQAGKHVVHIACG 560

Query: 506  QNCTFVIQANGTVLACGEGSYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGS-DGHS 682
               +  I A G +   G G+YGRLG G+S+D  +  +++ L+G  V  +  +CGS D  +
Sbjct: 561  STYSAAITAEGELYTWGRGNYGRLGHGSSEDEAIPMLVAGLKGLKVIDV--ACGSGDAQT 618

Query: 683  MALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGK 862
            +A+TE+G+V+SWGDGDYGKLG G SD  + P+ IE LQ  +VV++ CG + S  +T DG+
Sbjct: 619  LAVTENGQVWSWGDGDYGKLGRGGSDGCKTPKLIEKLQDLDVVKVRCGSQFSVALTKDGQ 678

Query: 863  LFTFGNGDYGRLGLGNTSNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDG 1042
            ++++G GD  RLG G   + + P+ +  L+G ++  VA G  H LA++ D S V ++G  
Sbjct: 679  VYSWGKGDNQRLGHGTEEHVRYPKLLEGLQGKKVIDVAAGSTHCLALTED-SEVHSWGSN 737

Query: 1043 DYGKLGLGNSTAKSSPQKVDVLCGIGIKKVACGTQFSVA 1159
            D  +        K  P  +  L    I  +ACG   S A
Sbjct: 738  DQCQHFDTLRVTKPEPSALPGLDTKHIVGIACGPAQSFA 776



 Score =  138 bits (347), Expect = 4e-32
 Identities = 95/273 (34%), Positives = 136/273 (49%), Gaps = 5/273 (1%)
 Frame = +2

Query: 674  GHSMALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTS 853
            G   A T   +VF WG  D  +LG     + + P   E L    VVQ++ G K    VT 
Sbjct: 2951 GLESAATIRTKVFVWGLNDKDQLGGLKGSKIKVPSFSETLSALNVVQVAGGSKSLFAVTV 3010

Query: 854  DGKLFTFGNGDYGRLGLGNTSNK-KLPERVTALEGYQIGQVA--CGLNHTLAVSADGSMV 1024
            +GK++  G    GRLGLG +S    +P ++TAL  Y + +VA   G  H  A++ DG  V
Sbjct: 3011 EGKVYACGEATNGRLGLGISSGTVPIPRQITALSSYVVKKVAVHSGGRHATALTVDGK-V 3069

Query: 1025 WAFGDGDYGKLGLGNSTAKSSPQKVDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRL 1204
            +++G+GD GKLG  +      P+ ++ L    I+ +ACG+  S ALT  G +YT+G    
Sbjct: 3070 FSWGEGDDGKLGHFSRMNCDKPRLIEALKTKRIRDIACGSSHSAALTSSGELYTWGLGEY 3129

Query: 1205 IGLPEGRARNHNRPQQIPVLAGVVIEDVAVGAE--HTLALASTGDVYAWGSNSEGQLGLG 1378
              L  G      +P+ + VL G  +  VA G+    TLAL   G V++WG    G+LG G
Sbjct: 3130 GRLGHGDNTTQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFSWGDGDFGKLGRG 3189

Query: 1379 HTNHVREPTLVTVLQGKNVRQISAGRCHSAAWT 1477
             +     P  +  L G+ V QI  G   S A T
Sbjct: 3190 GSEGCNIPQNIERLNGQGVCQIECGAQFSLALT 3222



 Score = 68.6 bits (166), Expect = 4e-11
 Identities = 46/139 (33%), Positives = 73/139 (52%), Gaps = 8/139 (5%)
 Frame = +2

Query: 1088 PQKVDVLCGIGIKKVACGTQFSVALTKDGHVYT--FGQDRLIGLPEGRARNHNRPQQIPV 1261
            P + + L  +G+ ++AC  +  + L+++G VYT  +  D L             PQ +  
Sbjct: 443  PIQCEGLANLGVTQIACAEKRFLILSRNGRVYTQAYNSDTL------------APQLVQG 490

Query: 1262 LAGVVIEDVAVGAE--HTLALASTGDVYAWGSNSEGQLGLGHTNHVREPTLVTVLQ---- 1423
            LA   I  +A  ++  H LALA+TG+VY+WG    G+LG G T  + EP +++       
Sbjct: 491  LASRNIVKIAAHSDGHHYLALAATGEVYSWGCGDGGRLGHGDTVPLEEPKVISAFSGKQA 550

Query: 1424 GKNVRQISAGRCHSAAWTA 1480
            GK+V  I+ G  +SAA TA
Sbjct: 551  GKHVVHIACGSTYSAAITA 569


>ref|NP_001092431.1| probable E3 ubiquitin-protein ligase HECTD3 [Bos taurus].
          Length = 861

 Score =  192 bits (487), Expect = 2e-48
 Identities = 123/349 (35%), Positives = 183/349 (52%), Gaps = 9/349 (2%)
 Frame = +2

Query: 1910 DLRLPSRA---WKVKLVGEGADDAGGVFDDTITEMCQELETGIVDLLIPSP------NAT 2062
            D R P R    W+ K + EG  D GG F D++ +M +EL     D  +P P      N  
Sbjct: 517  DYRWPMRYDQWWECKFIAEGIIDQGGGFRDSLADMSEELCPSSADTPVPLPFFVRTANQG 576

Query: 2063 AEVGYNRDRFLFNPSACLDEHLMQFKFLGILMGVAIRTKKPLDLHLAPLVWKQLCCVPXX 2242
               G  RD ++ NPS C D    +++++G LMG A+R K+ L L L   VWKQL      
Sbjct: 577  NGTGEARDMYVPNPS-CRD--FAKYEWIGQLMGAALRGKEFLVLALPGFVWKQLSGEEVS 633

Query: 2243 XXXXXXXXXXYVQTLNSILHIEDSGITEESFHEMIPLDSFVGQSADGKMVPIIPGGNSIP 2422
                       +  L  ++   D    E  F + +   +F    +D ++V +IPGG+ I 
Sbjct: 634  WSKDFPAVDSVLVKLLEVMEGMDKETFEFKFGKEL---TFTTVLSDQQVVELIPGGSGIV 690

Query: 2423 LTFSNRKEYVERAIEYRLHEMDRQVAAVREGMSWIVPVPLLSLLTAKQLEQMVCGMPEIS 2602
            + + +R  +++   + RL E   QVAA++ G+  +VP  +L LLT ++LE+ VCG PE++
Sbjct: 691  VGYEDRSRFIQLVQKARLEESKEQVAAMQAGLLKVVPQAVLDLLTWQELEKKVCGDPEVT 750

Query: 2603 VEVLKKVVRYREVDEQHQLVQWFWHTLEEFSNEERVLFMRFVSGRSRLPANTADISQRFQ 2782
            V+ L+K+ R+ + +     VQ+FW  L  F+NE+R  F+RFV+GRSRLPA       +  
Sbjct: 751  VDALRKLTRFEDFEPSDTRVQYFWEALNNFTNEDRSRFLRFVTGRSRLPARIYIYPDKLG 810

Query: 2783 IMKVDRPYDSLPTSQTCFFQLRLPPYSSQLVMAERLRYAINNCRSIDMD 2929
                    D+LP S TC   L LP Y+S  V  E+LRYA  NC +ID D
Sbjct: 811  Y----ETTDALPESSTCSSTLFLPHYASAKVCEEKLRYAAYNCVAIDTD 855


>ref|NP_001077132.1| probable E3 ubiquitin-protein ligase HERC3 [Bos taurus].
          Length = 1050

 Score =  176 bits (445), Expect = 2e-43
 Identities = 112/325 (34%), Positives = 177/325 (54%), Gaps = 6/325 (1%)
 Frame = +2

Query: 494  VICGQNCTFVIQANGTVLACGEGSYGRLG---QGNSDDLHVLTVISALQGFVVTQLVTSC 664
            V CG N +  +  +G V  CG  + G+LG   +GN  +      I AL    +  +  +C
Sbjct: 39   VACGGNHSVFLLEDGEVYTCGVNTKGQLGHEREGNKPEQ-----IGALADQHIVHV--AC 91

Query: 665  GSDGHSMALTESGEVFSWGDGDYGKLGHGN-SDRQRRPRQIEALQGEEVVQMSCGFKHSA 841
            G + HS+AL++ G++FSWG G  G+LG     D    PR I+ L  + ++Q+SCG  H  
Sbjct: 92   G-ESHSLALSDQGQLFSWGAGSDGQLGLMTIEDSVAVPRLIQKLNQQTILQVSCGNWHCL 150

Query: 842  VVTSDGKLFTFGNGDYGRLGLGNT-SNKKLPERVTALEGYQIGQVACGLNHTLAVSADGS 1018
             + +DG+ FT+G   +G+LGLG    ++  P+RV +LEG  + QV  G  H+ A+S  G+
Sbjct: 151  ALAADGQFFTWGRNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVVAGGAHSFALSLSGA 210

Query: 1019 MVWAFGDGDYGKLGLGNSTAKSSPQKVDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQD 1198
             V+ +G  + G+LGL +   + SP  V +L    +  ++CG + +  LTK G V+TFG  
Sbjct: 211  -VFGWGMNNAGQLGLSDEKDRESPCHVKLLRTQKVVYISCGEEHTAVLTKSGGVFTFGAG 269

Query: 1199 RLIGLPEGRARNHNRPQQIPVLAGVVIEDVAVGAEHTLALA-STGDVYAWGSNSEGQLGL 1375
                L      +   P+++  L G  +  +A G +HTLA   S+G +YA+G  + GQLG 
Sbjct: 270  SCGQLGHDSMNDEVNPRRVLELMGSEVTQIACGRQHTLAFVPSSGLIYAFGCGARGQLGT 329

Query: 1376 GHTNHVREPTLVTVLQGKNVRQISA 1450
            GHT +V+ P+ V      +  Q+SA
Sbjct: 330  GHTCNVKCPSPVKGYWAAHSGQLSA 354



 Score =  154 bits (390), Expect = 4e-37
 Identities = 105/308 (34%), Positives = 161/308 (52%), Gaps = 5/308 (1%)
 Frame = +2

Query: 566  YGRLGQ-GNSDDLHVLTVISALQGFVVTQLV--TSCGSDGHSMALTESGEVFSWGDGDYG 736
            Y  LGQ G S +L  +     + GF+  + V   +CG + HS+ L E GEV++ G    G
Sbjct: 6    YWSLGQPGISPNLQGIVAEPQVCGFISDRSVKEVACGGN-HSVFLLEDGEVYTCGVNTKG 64

Query: 737  KLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLGLGNTS 916
            +LGH       +P QI AL  + +V ++CG  HS  ++  G+LF++G G  G+LGL    
Sbjct: 65   QLGHEREGN--KPEQIGALADQHIVHVACGESHSLALSDQGQLFSWGAGSDGQLGLMTIE 122

Query: 917  NK-KLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNS-TAKSSP 1090
            +   +P  +  L    I QV+CG  H LA++ADG   + +G   +G+LGLG    +++SP
Sbjct: 123  DSVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQF-FTWGRNSHGQLGLGKEFPSQASP 181

Query: 1091 QKVDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGLPEGRARNHNRPQQIPVLAG 1270
            Q+V  L GI + +V  G   S AL+  G V+ +G +    L     ++   P  + +L  
Sbjct: 182  QRVRSLEGIPLAQVVAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEKDRESPCHVKLLRT 241

Query: 1271 VVIEDVAVGAEHTLALASTGDVYAWGSNSEGQLGLGHTNHVREPTLVTVLQGKNVRQISA 1450
              +  ++ G EHT  L  +G V+ +G+ S GQLG    N    P  V  L G  V QI+ 
Sbjct: 242  QKVVYISCGEEHTAVLTKSGGVFTFGAGSCGQLGHDSMNDEVNPRRVLELMGSEVTQIAC 301

Query: 1451 GRCHSAAW 1474
            GR H+ A+
Sbjct: 302  GRQHTLAF 309



 Score =  133 bits (335), Expect = 1e-30
 Identities = 84/262 (32%), Positives = 127/262 (48%), Gaps = 5/262 (1%)
 Frame = +2

Query: 329  DEQIMSWATSRPEDWHLGGKCDVYLWGAGRHGQLA----EAGRNVMVXXXXXXXXXXXXV 496
            D+ I+  A        L  +  ++ WGAG  GQL     E    V              V
Sbjct: 83   DQHIVHVACGESHSLALSDQGQLFSWGAGSDGQLGLMTIEDSVAVPRLIQKLNQQTILQV 142

Query: 497  ICGQNCTFVIQANGTVLACGEGSYGRLGQGNSDDLHVLTV-ISALQGFVVTQLVTSCGSD 673
             CG      + A+G     G  S+G+LG G           + +L+G  + Q+V      
Sbjct: 143  SCGNWHCLALAADGQFFTWGRNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVVAG---G 199

Query: 674  GHSMALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTS 853
             HS AL+ SG VF WG  + G+LG  +   +  P  ++ L+ ++VV +SCG +H+AV+T 
Sbjct: 200  AHSFALSLSGAVFGWGMNNAGQLGLSDEKDRESPCHVKLLRTQKVVYISCGEEHTAVLTK 259

Query: 854  DGKLFTFGNGDYGRLGLGNTSNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAF 1033
             G +FTFG G  G+LG  + +++  P RV  L G ++ Q+ACG  HTLA      +++AF
Sbjct: 260  SGGVFTFGAGSCGQLGHDSMNDEVNPRRVLELMGSEVTQIACGRQHTLAFVPSSGLIYAF 319

Query: 1034 GDGDYGKLGLGNSTAKSSPQKV 1099
            G G  G+LG G++     P  V
Sbjct: 320  GCGARGQLGTGHTCNVKCPSPV 341



 Score =  121 bits (304), Expect = 4e-27
 Identities = 78/237 (32%), Positives = 124/237 (52%), Gaps = 2/237 (0%)
 Frame = +2

Query: 773  PRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLGLGNTSNKKLPERVTALE 952
            P+    +    V +++CG  HS  +  DG+++T G    G+LG     NK  PE++ AL 
Sbjct: 25   PQVCGFISDRSVKEVACGGNHSVFLLEDGEVYTCGVNTKGQLGHEREGNK--PEQIGALA 82

Query: 953  GYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGN-STAKSSPQKVDVLCGIGIKK 1129
               I  VACG +H+LA+S  G + +++G G  G+LGL     + + P+ +  L    I +
Sbjct: 83   DQHIVHVACGESHSLALSDQGQL-FSWGAGSDGQLGLMTIEDSVAVPRLIQKLNQQTILQ 141

Query: 1130 VACGTQFSVALTKDGHVYTFGQDRLIGLPEGRA-RNHNRPQQIPVLAGVVIEDVAVGAEH 1306
            V+CG    +AL  DG  +T+G++    L  G+   +   PQ++  L G+ +  V  G  H
Sbjct: 142  VSCGNWHCLALAADGQFFTWGRNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVVAGGAH 201

Query: 1307 TLALASTGDVYAWGSNSEGQLGLGHTNHVREPTLVTVLQGKNVRQISAGRCHSAAWT 1477
            + AL+ +G V+ WG N+ GQLGL        P  V +L+ + V  IS G  H+A  T
Sbjct: 202  SFALSLSGAVFGWGMNNAGQLGLSDEKDRESPCHVKLLRTQKVVYISCGEEHTAVLT 258



 Score = 93.6 bits (231), Expect = 1e-18
 Identities = 89/337 (26%), Positives = 143/337 (42%), Gaps = 4/337 (1%)
 Frame = +2

Query: 1910 DLRLPSRAWKVKLVGEGADDAGGVFDDTITEMCQELETGIVDLLIPSPNATAEVGYNRDR 2089
            DL+ P    KV   GE A DAGGV  +    + +EL   I  +            Y    
Sbjct: 726  DLKKPL---KVIFDGEEAVDAGGVTKEFFLLLLKELLNPIYGMF---------TYYQDSN 773

Query: 2090 FLFNPSACLDEHLMQFKFLGILMGVAIRTKKPLDLHLAPLVWKQLCCVPXXXXXXXXXXX 2269
             L+    C  EH   F  +GI  G+AI     +DLH    ++K+L  V            
Sbjct: 774  LLWFSDTCFVEHNW-FHLIGITCGLAIYNSTVVDLHFPLALYKKLLNVKPGLEDLKELSP 832

Query: 2270 XYVQTLNSILHIEDSGITEESFHEMIPLDSFVGQSADG--KMVPIIPGGNSIPLTFSNRK 2443
               ++L  +L      I EE+F     L+  + + + G  +   +IPGG+ + +   NR+
Sbjct: 833  TEGRSLQELLDYPGEDI-EETFC----LNFTICRESYGVIEQKKLIPGGDKVTVCKENRQ 887

Query: 2444 EYVERAIEYRLH-EMDRQVAAVREGMSWIVPVPLLSLLTAKQLEQMVCGMPEISVEVLKK 2620
            E+V+  + Y     +     A   G   +    +L L    +L  M+ G    + E L++
Sbjct: 888  EFVDAYVNYVFQISVHEWYTAFSSGFLKVCGGKVLELFQPSELRAMMVGNSSYNWEELEE 947

Query: 2621 VVRYR-EVDEQHQLVQWFWHTLEEFSNEERVLFMRFVSGRSRLPANTADISQRFQIMKVD 2797
               Y+ +    H  V+ FW T  E   E++  F+ F++G  R+P      S +  I    
Sbjct: 948  TAIYKGDYSATHPTVKLFWETFHELPLEKKKKFLLFLTGSDRIPIYGM-ASLQIVIQSTA 1006

Query: 2798 RPYDSLPTSQTCFFQLRLPPYSSQLVMAERLRYAINN 2908
               + LP + TC+  L LP YSS+ V+  RL  A++N
Sbjct: 1007 SGEEYLPVAHTCYNLLDLPKYSSKEVLRARLTQALDN 1043


>ref|NP_001070362.2| hect domain and RLD 4 [Bos taurus].
          Length = 1057

 Score =  160 bits (405), Expect = 7e-39
 Identities = 104/314 (33%), Positives = 164/314 (52%), Gaps = 3/314 (0%)
 Frame = +2

Query: 542  VLACGEGSYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSD-GHSMALTESGEVFSW 718
            +L  G  S+G+LG G  D+  VL    +   F + + V   G    H++ + + G V++ 
Sbjct: 1    MLCWGNASFGQLGLGGIDEEIVLEPRKS--DFFINKKVRDVGCGLRHTVFVLDDGTVYTC 58

Query: 719  GDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRL 898
            G  D G+LGH  S  +++P Q+ AL  + +V +SCG  H+  +   G+++ +G    G+L
Sbjct: 59   GCNDLGQLGHEKS--RKKPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQL 116

Query: 899  GL-GNTSNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNST 1075
            GL G+    ++P  + +L   QI QVACG  H+LA+S   S V+ +G   YG+LGLG   
Sbjct: 117  GLLGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSK-ASEVFCWGQNKYGQLGLGIDC 175

Query: 1076 AK-SSPQKVDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGLPEGRARNHNRPQQ 1252
             K +SPQ +  L GI   ++A G   S  LT  G ++ +G+++   L      +   P  
Sbjct: 176  KKQASPQLIKSLLGIPFMQIAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNL 235

Query: 1253 IPVLAGVVIEDVAVGAEHTLALASTGDVYAWGSNSEGQLGLGHTNHVREPTLVTVLQGKN 1432
            +  L    I  +  G +HT AL   G V+ +G+   GQLG   T+H   P  V  L G  
Sbjct: 236  LKSLRTQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSI 295

Query: 1433 VRQISAGRCHSAAW 1474
            V QI+ GR H++A+
Sbjct: 296  VTQIACGRQHTSAF 309



 Score =  158 bits (400), Expect = 3e-38
 Identities = 97/307 (31%), Positives = 160/307 (52%), Gaps = 3/307 (0%)
 Frame = +2

Query: 500  CGQNCTFVIQANGTVLACGEGSYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSDGH 679
            CG   T  +  +GTV  CG    G+LG   S       V    Q  V      SCG + H
Sbjct: 41   CGLRHTVFVLDDGTVYTCGCNDLGQLGHEKSRKKPEQVVALDAQNIV----AVSCG-EAH 95

Query: 680  SMALTESGEVFSWGDGDYGKLG-HGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSD 856
            ++AL + G+V++WG    G+LG  G+ +  R PR I++L   ++VQ++CG+ HS  ++  
Sbjct: 96   TLALNDKGQVYAWGLDSDGQLGLLGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKA 155

Query: 857  GKLFTFGNGDYGRLGLGNTSNKKL-PERVTALEGYQIGQVACGLNHTLAVSADGSMVWAF 1033
             ++F +G   YG+LGLG    K+  P+ + +L G    Q+A G  H+  ++  G+ ++ +
Sbjct: 156  SEVFCWGQNKYGQLGLGIDCKKQASPQLIKSLLGIPFMQIAAGGAHSFVLTLSGA-IFGW 214

Query: 1034 GDGDYGKLGLGNSTAKSSPQKVDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGL 1213
            G   +G+LGL +   +  P  +  L    I  + CG   + ALTK+G V+TFG      L
Sbjct: 215  GRNKFGQLGLNDENDRYVPNLLKSLRTQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQL 274

Query: 1214 PEGRARNHNRPQQIPVLAGVVIEDVAVGAEHTLA-LASTGDVYAWGSNSEGQLGLGHTNH 1390
                  +   P+++  L G ++  +A G +HT A + S+G +Y++G    GQLG G T++
Sbjct: 275  GHNSTSHEINPRKVFELMGSIVTQIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSN 334

Query: 1391 VREPTLV 1411
             + P  V
Sbjct: 335  RKSPFTV 341



 Score =  146 bits (368), Expect = 1e-34
 Identities = 90/258 (34%), Positives = 137/258 (53%), Gaps = 4/258 (1%)
 Frame = +2

Query: 716  WGDGDYGKLGHGNSDRQ--RRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDY 889
            WG+  +G+LG G  D +    PR+ +    ++V  + CG +H+  V  DG ++T G  D 
Sbjct: 4    WGNASFGQLGLGGIDEEIVLEPRKSDFFINKKVRDVGCGLRHTVFVLDDGTVYTCGCNDL 63

Query: 890  GRLGLGNTSNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGL-G 1066
            G+LG  +  ++K PE+V AL+   I  V+CG  HTLA++ D   V+A+G    G+LGL G
Sbjct: 64   GQLG--HEKSRKKPEQVVALDAQNIVAVSCGEAHTLALN-DKGQVYAWGLDSDGQLGLLG 120

Query: 1067 NSTAKSSPQKVDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGLPEG-RARNHNR 1243
            +      P+ +  L  I I +VACG   S+AL+K   V+ +GQ++   L  G   +    
Sbjct: 121  SEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGIDCKKQAS 180

Query: 1244 PQQIPVLAGVVIEDVAVGAEHTLALASTGDVYAWGSNSEGQLGLGHTNHVREPTLVTVLQ 1423
            PQ I  L G+    +A G  H+  L  +G ++ WG N  GQLGL   N    P L+  L+
Sbjct: 181  PQLIKSLLGIPFMQIAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLR 240

Query: 1424 GKNVRQISAGRCHSAAWT 1477
             + +  I  G  H+AA T
Sbjct: 241  TQKIVYICCGEDHTAALT 258



 Score =  127 bits (320), Expect = 5e-29
 Identities = 76/243 (31%), Positives = 117/243 (48%), Gaps = 5/243 (2%)
 Frame = +2

Query: 377  LGGKCDVYLWGAGRHGQLAEAGRNVMVXXXXXXXXXXXX----VICGQNCTFVIQANGTV 544
            L  K  VY WG    GQL   G    +                V CG   +  +     V
Sbjct: 99   LNDKGQVYAWGLDSDGQLGLLGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEV 158

Query: 545  LACGEGSYGRLGQGNSDDLHVLT-VISALQGFVVTQLVTSCGSDGHSMALTESGEVFSWG 721
               G+  YG+LG G          +I +L G    Q+        HS  LT SG +F WG
Sbjct: 159  FCWGQNKYGQLGLGIDCKKQASPQLIKSLLGIPFMQIAAG---GAHSFVLTLSGAIFGWG 215

Query: 722  DGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLG 901
               +G+LG  + + +  P  +++L+ +++V + CG  H+A +T +G +FTFG G YG+LG
Sbjct: 216  RNKFGQLGLNDENDRYVPNLLKSLRTQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLG 275

Query: 902  LGNTSNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNSTAK 1081
              +TS++  P +V  L G  + Q+ACG  HT A       +++FG G  G+LG G+++ +
Sbjct: 276  HNSTSHEINPRKVFELMGSIVTQIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSNR 335

Query: 1082 SSP 1090
             SP
Sbjct: 336  KSP 338



 Score =  111 bits (277), Expect = 5e-24
 Identities = 65/209 (31%), Positives = 110/209 (52%), Gaps = 8/209 (3%)
 Frame = +2

Query: 329 DEQIMSWATSRPEDWHLGGKCDVYLWGAGRHGQLA-------EAGRNVMVXXXXXXXXXX 487
           D QI+  A        L    +V+ WG  ++GQL        +A   ++           
Sbjct: 136 DIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGIDCKKQASPQLI---KSLLGIPF 192

Query: 488 XXVICGQNCTFVIQANGTVLACGEGSYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCG 667
             +  G   +FV+  +G +   G   +G+LG  + +D +V  ++ +L+     ++V  C 
Sbjct: 193 MQIAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLR---TQKIVYICC 249

Query: 668 SDGHSMALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKH-SAV 844
            + H+ ALT+ G VF++G G YG+LGH ++  +  PR++  L G  V Q++CG +H SA 
Sbjct: 250 GEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTQIACGRQHTSAF 309

Query: 845 VTSDGKLFTFGNGDYGRLGLGNTSNKKLP 931
           V S G++++FG G  G+LG G+TSN+K P
Sbjct: 310 VPSSGRIYSFGLGGNGQLGTGSTSNRKSP 338



 Score = 73.2 bits (178), Expect = 2e-12
 Identities = 78/329 (23%), Positives = 138/329 (41%), Gaps = 5/329 (1%)
 Frame = +2

Query: 1937 KVKLVGEGADDAGGVFDDTITEMCQELETGIVDLLIPSPNATAEVGYNRDRFL-FNPSAC 2113
            KV  VGE A DAGGV  +    + +EL           P       Y   R + F+    
Sbjct: 739  KVIFVGEDAVDAGGVRKEFFLLIMRELL---------DPKYGMFRYYEDSRLIWFSDKTF 789

Query: 2114 LDEHLMQFKFLGILMGVAIRTKKPLDLHLAPLVWKQLCCVPXXXXXXXXXXXXYVQTLNS 2293
             D  L  F  +G++ G+AI     +DLH    ++K+L                  +++  
Sbjct: 790  EDSDL--FHLIGVICGLAIYNFTIVDLHFPLALYKKLLKKKPSLEDLKELVPDVGRSMQQ 847

Query: 2294 ILHIEDSGITEESF--HEMIPLDSFVGQSADGKMVPIIPGGNSIPLTFSNRKEYVERAIE 2467
            +L   +  + EE+F  +  I +++F       ++  ++  G    +   NR+E+V+  ++
Sbjct: 848  LLDYPEDDV-EETFCLNFTITVENFGAT----EVKELVLNGADTAVNKQNRQEFVDAYVD 902

Query: 2468 YRLHEMDRQVA-AVREGMSWIVPVPLLSLLTAKQLEQMVCGMPEISVEVLKKVVRYR-EV 2641
            Y  ++    +  A   G   +    +L L    +L+ MV G      + L+K   Y+ E 
Sbjct: 903  YIFNKSVASLFDAFHAGFHKVCGGKVLQLFQPNELQAMVIGNTNYDWKELEKNTEYKGEY 962

Query: 2642 DEQHQLVQWFWHTLEEFSNEERVLFMRFVSGRSRLPANTADISQRFQIMKVDRPYDSLPT 2821
              +H  ++ FW    E   E++  F+ F++G  R+P      S    I       + LP 
Sbjct: 963  WAEHPTIKMFWEVFHELPLEKKKQFLLFLTGSDRIPI-LGMKSLILVIQSTGGGEEYLPV 1021

Query: 2822 SQTCFFQLRLPPYSSQLVMAERLRYAINN 2908
            S TCF  L LP Y+ +  +  +L  AI++
Sbjct: 1022 SHTCFNLLDLPKYTDKETLRSKLIQAIDH 1050


>ref|NP_001179573.1| probable E3 ubiquitin-protein ligase HERC6 [Bos taurus].
          Length = 1016

 Score =  156 bits (395), Expect = 1e-37
 Identities = 101/327 (30%), Positives = 174/327 (53%), Gaps = 10/327 (3%)
 Frame = +2

Query: 398  YLWGAGRHGQLAE----AGRNVMVXXXXXXXXXXXXVICGQNCTFVIQANGTVLACGEGS 565
            + W AG    L E    AG N ++               G++ + ++ ++GTV +CG+ S
Sbjct: 3    FCWRAGGRRPLRERQVCAGGNTLLQ-----------AASGEHHSLLLLSDGTVQSCGDNS 51

Query: 566  YGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSDGHSMALTESGEVFSWGDGDYGKLG 745
             G+LG+  +        I AL+   V   + SCG + HS+A+   G VF+WG    G+LG
Sbjct: 52   RGQLGRKGTPRGEQPERIPALETLNVA--LVSCGKE-HSLAVCHKGRVFAWGAASEGQLG 108

Query: 746  HGN-SDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLGLGNT-SN 919
             G   +    P++I+ L G +++Q++CG  HS  ++ DG++F++G   +G+LGLG    +
Sbjct: 109  IGEFKETTFIPKKIKTLAGIKIIQVACGHYHSVALSEDGQVFSWGTNSHGQLGLGKEFPS 168

Query: 920  KKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNSTA---KSSP 1090
            +  P+RV +LEG  + QVA G +H+ A+S  G+  + +G    G+L L  + A   +  P
Sbjct: 169  QASPQRVRSLEGIPLAQVAAGGHHSFALSLSGTS-FGWGSNSAGQLALSGNNAPVQRYKP 227

Query: 1091 QKVDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGLPEGRARNHNRPQQIPVLAG 1270
              +  L  +G+  ++CG + +  LT+DG V+TFG +    L          PQ +  + G
Sbjct: 228  VSIGALKTLGVVSISCGYKHTAVLTQDGKVFTFGDNSYGQLGHDPTAEKRGPQLVERIEG 287

Query: 1271 VVIEDVAVGAEHTLA-LASTGDVYAWG 1348
            +V   +  G++HTLA + +TG V ++G
Sbjct: 288  LV-SQIDCGSDHTLAYIYTTGQVVSFG 313



 Score =  149 bits (376), Expect = 2e-35
 Identities = 97/280 (34%), Positives = 149/280 (53%), Gaps = 5/280 (1%)
 Frame = +2

Query: 650  LVTSCGSDGHSMALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGF 829
            L+ +   + HS+ L   G V S GD   G+LG   + R  +P +I AL+   V  +SCG 
Sbjct: 25   LLQAASGEHHSLLLLSDGTVQSCGDNSRGQLGRKGTPRGEQPERIPALETLNVALVSCGK 84

Query: 830  KHSAVVTSDGKLFTFGNGDYGRLGLGNTSNKK-LPERVTALEGYQIGQVACGLNHTLAVS 1006
            +HS  V   G++F +G    G+LG+G       +P+++  L G +I QVACG  H++A+S
Sbjct: 85   EHSLAVCHKGRVFAWGAASEGQLGIGEFKETTFIPKKIKTLAGIKIIQVACGHYHSVALS 144

Query: 1007 ADGSMVWAFGDGDYGKLGLGNS-TAKSSPQKVDVLCGIGIKKVACGTQFSVALTKDGHVY 1183
             DG  V+++G   +G+LGLG    +++SPQ+V  L GI + +VA G   S AL+  G  +
Sbjct: 145  EDG-QVFSWGTNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGHHSFALSLSGTSF 203

Query: 1184 TFGQDRL--IGLPEGRAR-NHNRPQQIPVLAGVVIEDVAVGAEHTLALASTGDVYAWGSN 1354
             +G +    + L    A     +P  I  L  + +  ++ G +HT  L   G V+ +G N
Sbjct: 204  GWGSNSAGQLALSGNNAPVQRYKPVSIGALKTLGVVSISCGYKHTAVLTQDGKVFTFGDN 263

Query: 1355 SEGQLGLGHTNHVREPTLVTVLQGKNVRQISAGRCHSAAW 1474
            S GQLG   T   R P LV  ++G  V QI  G  H+ A+
Sbjct: 264  SYGQLGHDPTAEKRGPQLVERIEGL-VSQIDCGSDHTLAY 302



 Score =  135 bits (339), Expect = 3e-31
 Identities = 89/244 (36%), Positives = 131/244 (53%), Gaps = 5/244 (2%)
 Frame = +2

Query: 761  RQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLGLGNTSNKKLPERV 940
            R  R RQ+ A  G  ++Q + G  HS ++ SDG + + G+   G+LG   T   + PER+
Sbjct: 11   RPLRERQVCA-GGNTLLQAASGEHHSLLLLSDGTVQSCGDNSRGQLGRKGTPRGEQPERI 69

Query: 941  TALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGN-STAKSSPQKVDVLCGI 1117
             ALE   +  V+CG  H+LAV   G  V+A+G    G+LG+G        P+K+  L GI
Sbjct: 70   PALETLNVALVSCGKEHSLAVCHKG-RVFAWGAASEGQLGIGEFKETTFIPKKIKTLAGI 128

Query: 1118 GIKKVACGTQFSVALTKDGHVYTFGQDRLIGLPEGRA-RNHNRPQQIPVLAGVVIEDVAV 1294
             I +VACG   SVAL++DG V+++G +    L  G+   +   PQ++  L G+ +  VA 
Sbjct: 129  KIIQVACGHYHSVALSEDGQVFSWGTNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAA 188

Query: 1295 GAEHTLALASTGDVYAWGSNSEGQLGLGHTN---HVREPTLVTVLQGKNVRQISAGRCHS 1465
            G  H+ AL+ +G  + WGSNS GQL L   N      +P  +  L+   V  IS G  H+
Sbjct: 189  GGHHSFALSLSGTSFGWGSNSAGQLALSGNNAPVQRYKPVSIGALKTLGVVSISCGYKHT 248

Query: 1466 AAWT 1477
            A  T
Sbjct: 249  AVLT 252



 Score =  118 bits (296), Expect = 3e-26
 Identities = 80/255 (31%), Positives = 122/255 (47%), Gaps = 8/255 (3%)
 Frame = +2

Query: 395  VYLWGAGRHGQLA----EAGRNVMVXXXXXXXXXXXXVICGQNCTFVIQANGTVLACGEG 562
            V+ WGA   GQL     +    +              V CG   +  +  +G V + G  
Sbjct: 96   VFAWGAASEGQLGIGEFKETTFIPKKIKTLAGIKIIQVACGHYHSVALSEDGQVFSWGTN 155

Query: 563  SYGRLGQGNSDDLHVLTV-ISALQGFVVTQLVTSCGSDGHSMALTESGEVFSWGDGDYGK 739
            S+G+LG G           + +L+G  + Q+        HS AL+ SG  F WG    G+
Sbjct: 156  SHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAG---GHHSFALSLSGTSFGWGSNSAGQ 212

Query: 740  L---GHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLGLGN 910
            L   G+    ++ +P  I AL+   VV +SCG+KH+AV+T DGK+FTFG+  YG+LG   
Sbjct: 213  LALSGNNAPVQRYKPVSIGALKTLGVVSISCGYKHTAVLTQDGKVFTFGDNSYGQLGHDP 272

Query: 911  TSNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNSTAKSSP 1090
            T+ K+ P+ V  +EG  + Q+ CG +HTLA       V +FG G     G  + +     
Sbjct: 273  TAEKRGPQLVERIEGL-VSQIDCGSDHTLAYIYTTGQVVSFGRGP----GCASRSPHPGA 327

Query: 1091 QKVDVLCGIGIKKVA 1135
            +  D+ C +  K +A
Sbjct: 328  ESSDISCLVSAKDLA 342



 Score = 60.8 bits (146), Expect = 8e-09
 Identities = 67/283 (23%), Positives = 117/283 (41%), Gaps = 8/283 (2%)
 Frame = +2

Query: 2084 DRFLFNPSACLDEHLMQFKFLGILMGVAIRTKKPLDLHLAPLVWKQLCCVPXXXXXXXXX 2263
            D +++ P     E  M F F G+L G+++     + L     ++K+L             
Sbjct: 737  DSYMWFPVKPKFEKKMYFLF-GMLCGLSLYNFNVVYLPFPLALFKKLLDQEPSLEDLKEL 795

Query: 2264 XXXYVQTLNSILHIEDSGITEE-----SFHEMIPLDSFVGQSADGKMVPIIPGGNSIPLT 2428
               + + L  +L+ + + I EE     S H             D   V +IP G S+ + 
Sbjct: 796  SPSFGKCLQEVLNDDANDIKEEFGLRFSIHW------------DQNDVDLIPNGISVFVD 843

Query: 2429 FSNRKEYVERAIEYRLHEMDRQV-AAVREGMSWIVPVPLLSLLTAKQLEQMVCGMPEISV 2605
             SN+K+YV + ++Y L+   + V    + G   +    +L     ++L + + G  +   
Sbjct: 844  QSNKKDYVSKCVDYVLNTSVKAVYEEFQRGFYKLFDKEILKHFKPEELMRAIIGNTDYDW 903

Query: 2606 EVLKKVVRYRE-VDEQHQLVQWFWHTLEEFSNEERVLFMRFVSGRSRLPA-NTADISQRF 2779
            E  +K   Y +   E H  +  FW      + +E+  F+ F++G  RL          RF
Sbjct: 904  EQFEKNSIYEQGYHESHPTILMFWKAFHSLTLDEKRKFLFFLTGNDRLHVKGIQKPGIRF 963

Query: 2780 QIMKVDRPYDSLPTSQTCFFQLRLPPYSSQLVMAERLRYAINN 2908
            +  +     D  P S TC   L LP YS+   + E L+ AIN+
Sbjct: 964  RCPETCSESD-FPKSLTCHNILELPEYSTMKKVKEALQRAINS 1005


>ref|XP_002688230.1| PREDICTED: hect domain and RLD 6-like isoform 2 [Bos taurus].
          Length = 1016

 Score =  156 bits (395), Expect = 1e-37
 Identities = 101/327 (30%), Positives = 174/327 (53%), Gaps = 10/327 (3%)
 Frame = +2

Query: 398  YLWGAGRHGQLAE----AGRNVMVXXXXXXXXXXXXVICGQNCTFVIQANGTVLACGEGS 565
            + W AG    L E    AG N ++               G++ + ++ ++GTV +CG+ S
Sbjct: 3    FCWRAGGRRPLRERQVCAGGNTLLQ-----------AASGEHHSLLLLSDGTVQSCGDNS 51

Query: 566  YGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSDGHSMALTESGEVFSWGDGDYGKLG 745
             G+LG+  +        I AL+   V   + SCG + HS+A+   G VF+WG    G+LG
Sbjct: 52   RGQLGRKGTPRGEQPERIPALETLNVA--LVSCGKE-HSLAVCHKGRVFAWGAASEGQLG 108

Query: 746  HGN-SDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLGLGNT-SN 919
             G   +    P++I+ L G +++Q++CG  HS  ++ DG++F++G   +G+LGLG    +
Sbjct: 109  IGEFKETTFIPKKIKTLAGIKIIQVACGHYHSVALSEDGQVFSWGTNSHGQLGLGKEFPS 168

Query: 920  KKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNSTA---KSSP 1090
            +  P+RV +LEG  + QVA G +H+ A+S  G+  + +G    G+L L  + A   +  P
Sbjct: 169  QASPQRVRSLEGIPLAQVAAGGHHSFALSLSGTS-FGWGSNSAGQLALSGNNAPVQRYKP 227

Query: 1091 QKVDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGLPEGRARNHNRPQQIPVLAG 1270
              +  L  +G+  ++CG + +  LT+DG V+TFG +    L          PQ +  + G
Sbjct: 228  VSIGALKTLGVVSISCGYKHTAVLTQDGKVFTFGDNSYGQLGHDPTAEKRGPQLVERIEG 287

Query: 1271 VVIEDVAVGAEHTLA-LASTGDVYAWG 1348
            +V   +  G++HTLA + +TG V ++G
Sbjct: 288  LV-SQIDCGSDHTLAYIYTTGQVVSFG 313



 Score =  149 bits (376), Expect = 2e-35
 Identities = 97/280 (34%), Positives = 149/280 (53%), Gaps = 5/280 (1%)
 Frame = +2

Query: 650  LVTSCGSDGHSMALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGF 829
            L+ +   + HS+ L   G V S GD   G+LG   + R  +P +I AL+   V  +SCG 
Sbjct: 25   LLQAASGEHHSLLLLSDGTVQSCGDNSRGQLGRKGTPRGEQPERIPALETLNVALVSCGK 84

Query: 830  KHSAVVTSDGKLFTFGNGDYGRLGLGNTSNKK-LPERVTALEGYQIGQVACGLNHTLAVS 1006
            +HS  V   G++F +G    G+LG+G       +P+++  L G +I QVACG  H++A+S
Sbjct: 85   EHSLAVCHKGRVFAWGAASEGQLGIGEFKETTFIPKKIKTLAGIKIIQVACGHYHSVALS 144

Query: 1007 ADGSMVWAFGDGDYGKLGLGNS-TAKSSPQKVDVLCGIGIKKVACGTQFSVALTKDGHVY 1183
             DG  V+++G   +G+LGLG    +++SPQ+V  L GI + +VA G   S AL+  G  +
Sbjct: 145  EDG-QVFSWGTNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGHHSFALSLSGTSF 203

Query: 1184 TFGQDRL--IGLPEGRAR-NHNRPQQIPVLAGVVIEDVAVGAEHTLALASTGDVYAWGSN 1354
             +G +    + L    A     +P  I  L  + +  ++ G +HT  L   G V+ +G N
Sbjct: 204  GWGSNSAGQLALSGNNAPVQRYKPVSIGALKTLGVVSISCGYKHTAVLTQDGKVFTFGDN 263

Query: 1355 SEGQLGLGHTNHVREPTLVTVLQGKNVRQISAGRCHSAAW 1474
            S GQLG   T   R P LV  ++G  V QI  G  H+ A+
Sbjct: 264  SYGQLGHDPTAEKRGPQLVERIEGL-VSQIDCGSDHTLAY 302



 Score =  135 bits (339), Expect = 3e-31
 Identities = 89/244 (36%), Positives = 131/244 (53%), Gaps = 5/244 (2%)
 Frame = +2

Query: 761  RQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLGLGNTSNKKLPERV 940
            R  R RQ+ A  G  ++Q + G  HS ++ SDG + + G+   G+LG   T   + PER+
Sbjct: 11   RPLRERQVCA-GGNTLLQAASGEHHSLLLLSDGTVQSCGDNSRGQLGRKGTPRGEQPERI 69

Query: 941  TALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGN-STAKSSPQKVDVLCGI 1117
             ALE   +  V+CG  H+LAV   G  V+A+G    G+LG+G        P+K+  L GI
Sbjct: 70   PALETLNVALVSCGKEHSLAVCHKG-RVFAWGAASEGQLGIGEFKETTFIPKKIKTLAGI 128

Query: 1118 GIKKVACGTQFSVALTKDGHVYTFGQDRLIGLPEGRA-RNHNRPQQIPVLAGVVIEDVAV 1294
             I +VACG   SVAL++DG V+++G +    L  G+   +   PQ++  L G+ +  VA 
Sbjct: 129  KIIQVACGHYHSVALSEDGQVFSWGTNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAA 188

Query: 1295 GAEHTLALASTGDVYAWGSNSEGQLGLGHTN---HVREPTLVTVLQGKNVRQISAGRCHS 1465
            G  H+ AL+ +G  + WGSNS GQL L   N      +P  +  L+   V  IS G  H+
Sbjct: 189  GGHHSFALSLSGTSFGWGSNSAGQLALSGNNAPVQRYKPVSIGALKTLGVVSISCGYKHT 248

Query: 1466 AAWT 1477
            A  T
Sbjct: 249  AVLT 252



 Score =  118 bits (296), Expect = 3e-26
 Identities = 80/255 (31%), Positives = 122/255 (47%), Gaps = 8/255 (3%)
 Frame = +2

Query: 395  VYLWGAGRHGQLA----EAGRNVMVXXXXXXXXXXXXVICGQNCTFVIQANGTVLACGEG 562
            V+ WGA   GQL     +    +              V CG   +  +  +G V + G  
Sbjct: 96   VFAWGAASEGQLGIGEFKETTFIPKKIKTLAGIKIIQVACGHYHSVALSEDGQVFSWGTN 155

Query: 563  SYGRLGQGNSDDLHVLTV-ISALQGFVVTQLVTSCGSDGHSMALTESGEVFSWGDGDYGK 739
            S+G+LG G           + +L+G  + Q+        HS AL+ SG  F WG    G+
Sbjct: 156  SHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAG---GHHSFALSLSGTSFGWGSNSAGQ 212

Query: 740  L---GHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLGLGN 910
            L   G+    ++ +P  I AL+   VV +SCG+KH+AV+T DGK+FTFG+  YG+LG   
Sbjct: 213  LALSGNNAPVQRYKPVSIGALKTLGVVSISCGYKHTAVLTQDGKVFTFGDNSYGQLGHDP 272

Query: 911  TSNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNSTAKSSP 1090
            T+ K+ P+ V  +EG  + Q+ CG +HTLA       V +FG G     G  + +     
Sbjct: 273  TAEKRGPQLVERIEGL-VSQIDCGSDHTLAYIYTTGQVVSFGRGP----GCASRSPHPGA 327

Query: 1091 QKVDVLCGIGIKKVA 1135
            +  D+ C +  K +A
Sbjct: 328  ESSDISCLVSAKDLA 342



 Score = 60.5 bits (145), Expect = 1e-08
 Identities = 48/180 (26%), Positives = 81/180 (45%), Gaps = 3/180 (1%)
 Frame = +2

Query: 2378 DGKMVPIIPGGNSIPLTFSNRKEYVERAIEYRLHEMDRQV-AAVREGMSWIVPVPLLSLL 2554
            D   V +IP G S+ +  SN+K+YV + ++Y L+   + V    + G   +    +L   
Sbjct: 827  DQNDVDLIPNGISVFVDQSNKKDYVSKCVDYVLNTSVKAVYEEFQRGFYKLFDKEILKHF 886

Query: 2555 TAKQLEQMVCGMPEISVEVLKKVVRYRE-VDEQHQLVQWFWHTLEEFSNEERVLFMRFVS 2731
              ++L + + G  +   E  +K   Y +   E H  +  FW      + +E+  F+ F++
Sbjct: 887  KPEELMRAIIGNTDYDWEQFEKNSIYEQGYHESHPTILMFWKAFHSLTLDEKRKFLFFLT 946

Query: 2732 GRSRLPA-NTADISQRFQIMKVDRPYDSLPTSQTCFFQLRLPPYSSQLVMAERLRYAINN 2908
            G  RL          RF+  +     D  P S TC   L LP YS+   + E L+ AIN+
Sbjct: 947  GNDRLHVKGIQKPGIRFRCPETCSESD-FPKSLTCHNILELPEYSTMKKVKEALQRAINS 1005


>ref|XP_002688229.1| PREDICTED: hect domain and RLD 6-like isoform 1 [Bos taurus].
          Length = 980

 Score =  156 bits (395), Expect = 1e-37
 Identities = 101/327 (30%), Positives = 174/327 (53%), Gaps = 10/327 (3%)
 Frame = +2

Query: 398  YLWGAGRHGQLAE----AGRNVMVXXXXXXXXXXXXVICGQNCTFVIQANGTVLACGEGS 565
            + W AG    L E    AG N ++               G++ + ++ ++GTV +CG+ S
Sbjct: 3    FCWRAGGRRPLRERQVCAGGNTLLQ-----------AASGEHHSLLLLSDGTVQSCGDNS 51

Query: 566  YGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSDGHSMALTESGEVFSWGDGDYGKLG 745
             G+LG+  +        I AL+   V   + SCG + HS+A+   G VF+WG    G+LG
Sbjct: 52   RGQLGRKGTPRGEQPERIPALETLNVA--LVSCGKE-HSLAVCHKGRVFAWGAASEGQLG 108

Query: 746  HGN-SDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLGLGNT-SN 919
             G   +    P++I+ L G +++Q++CG  HS  ++ DG++F++G   +G+LGLG    +
Sbjct: 109  IGEFKETTFIPKKIKTLAGIKIIQVACGHYHSVALSEDGQVFSWGTNSHGQLGLGKEFPS 168

Query: 920  KKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNSTA---KSSP 1090
            +  P+RV +LEG  + QVA G +H+ A+S  G+  + +G    G+L L  + A   +  P
Sbjct: 169  QASPQRVRSLEGIPLAQVAAGGHHSFALSLSGTS-FGWGSNSAGQLALSGNNAPVQRYKP 227

Query: 1091 QKVDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGLPEGRARNHNRPQQIPVLAG 1270
              +  L  +G+  ++CG + +  LT+DG V+TFG +    L          PQ +  + G
Sbjct: 228  VSIGALKTLGVVSISCGYKHTAVLTQDGKVFTFGDNSYGQLGHDPTAEKRGPQLVERIEG 287

Query: 1271 VVIEDVAVGAEHTLA-LASTGDVYAWG 1348
            +V   +  G++HTLA + +TG V ++G
Sbjct: 288  LV-SQIDCGSDHTLAYIYTTGQVVSFG 313



 Score =  149 bits (376), Expect = 2e-35
 Identities = 97/280 (34%), Positives = 149/280 (53%), Gaps = 5/280 (1%)
 Frame = +2

Query: 650  LVTSCGSDGHSMALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGF 829
            L+ +   + HS+ L   G V S GD   G+LG   + R  +P +I AL+   V  +SCG 
Sbjct: 25   LLQAASGEHHSLLLLSDGTVQSCGDNSRGQLGRKGTPRGEQPERIPALETLNVALVSCGK 84

Query: 830  KHSAVVTSDGKLFTFGNGDYGRLGLGNTSNKK-LPERVTALEGYQIGQVACGLNHTLAVS 1006
            +HS  V   G++F +G    G+LG+G       +P+++  L G +I QVACG  H++A+S
Sbjct: 85   EHSLAVCHKGRVFAWGAASEGQLGIGEFKETTFIPKKIKTLAGIKIIQVACGHYHSVALS 144

Query: 1007 ADGSMVWAFGDGDYGKLGLGNS-TAKSSPQKVDVLCGIGIKKVACGTQFSVALTKDGHVY 1183
             DG  V+++G   +G+LGLG    +++SPQ+V  L GI + +VA G   S AL+  G  +
Sbjct: 145  EDG-QVFSWGTNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGHHSFALSLSGTSF 203

Query: 1184 TFGQDRL--IGLPEGRAR-NHNRPQQIPVLAGVVIEDVAVGAEHTLALASTGDVYAWGSN 1354
             +G +    + L    A     +P  I  L  + +  ++ G +HT  L   G V+ +G N
Sbjct: 204  GWGSNSAGQLALSGNNAPVQRYKPVSIGALKTLGVVSISCGYKHTAVLTQDGKVFTFGDN 263

Query: 1355 SEGQLGLGHTNHVREPTLVTVLQGKNVRQISAGRCHSAAW 1474
            S GQLG   T   R P LV  ++G  V QI  G  H+ A+
Sbjct: 264  SYGQLGHDPTAEKRGPQLVERIEGL-VSQIDCGSDHTLAY 302



 Score =  135 bits (339), Expect = 3e-31
 Identities = 89/244 (36%), Positives = 131/244 (53%), Gaps = 5/244 (2%)
 Frame = +2

Query: 761  RQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLGLGNTSNKKLPERV 940
            R  R RQ+ A  G  ++Q + G  HS ++ SDG + + G+   G+LG   T   + PER+
Sbjct: 11   RPLRERQVCA-GGNTLLQAASGEHHSLLLLSDGTVQSCGDNSRGQLGRKGTPRGEQPERI 69

Query: 941  TALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGN-STAKSSPQKVDVLCGI 1117
             ALE   +  V+CG  H+LAV   G  V+A+G    G+LG+G        P+K+  L GI
Sbjct: 70   PALETLNVALVSCGKEHSLAVCHKG-RVFAWGAASEGQLGIGEFKETTFIPKKIKTLAGI 128

Query: 1118 GIKKVACGTQFSVALTKDGHVYTFGQDRLIGLPEGRA-RNHNRPQQIPVLAGVVIEDVAV 1294
             I +VACG   SVAL++DG V+++G +    L  G+   +   PQ++  L G+ +  VA 
Sbjct: 129  KIIQVACGHYHSVALSEDGQVFSWGTNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAA 188

Query: 1295 GAEHTLALASTGDVYAWGSNSEGQLGLGHTN---HVREPTLVTVLQGKNVRQISAGRCHS 1465
            G  H+ AL+ +G  + WGSNS GQL L   N      +P  +  L+   V  IS G  H+
Sbjct: 189  GGHHSFALSLSGTSFGWGSNSAGQLALSGNNAPVQRYKPVSIGALKTLGVVSISCGYKHT 248

Query: 1466 AAWT 1477
            A  T
Sbjct: 249  AVLT 252



 Score =  118 bits (296), Expect = 3e-26
 Identities = 80/255 (31%), Positives = 122/255 (47%), Gaps = 8/255 (3%)
 Frame = +2

Query: 395  VYLWGAGRHGQLA----EAGRNVMVXXXXXXXXXXXXVICGQNCTFVIQANGTVLACGEG 562
            V+ WGA   GQL     +    +              V CG   +  +  +G V + G  
Sbjct: 96   VFAWGAASEGQLGIGEFKETTFIPKKIKTLAGIKIIQVACGHYHSVALSEDGQVFSWGTN 155

Query: 563  SYGRLGQGNSDDLHVLTV-ISALQGFVVTQLVTSCGSDGHSMALTESGEVFSWGDGDYGK 739
            S+G+LG G           + +L+G  + Q+        HS AL+ SG  F WG    G+
Sbjct: 156  SHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAG---GHHSFALSLSGTSFGWGSNSAGQ 212

Query: 740  L---GHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLGLGN 910
            L   G+    ++ +P  I AL+   VV +SCG+KH+AV+T DGK+FTFG+  YG+LG   
Sbjct: 213  LALSGNNAPVQRYKPVSIGALKTLGVVSISCGYKHTAVLTQDGKVFTFGDNSYGQLGHDP 272

Query: 911  TSNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNSTAKSSP 1090
            T+ K+ P+ V  +EG  + Q+ CG +HTLA       V +FG G     G  + +     
Sbjct: 273  TAEKRGPQLVERIEGL-VSQIDCGSDHTLAYIYTTGQVVSFGRGP----GCASRSPHPGA 327

Query: 1091 QKVDVLCGIGIKKVA 1135
            +  D+ C +  K +A
Sbjct: 328  ESSDISCLVSAKDLA 342



 Score = 60.5 bits (145), Expect = 1e-08
 Identities = 48/180 (26%), Positives = 81/180 (45%), Gaps = 3/180 (1%)
 Frame = +2

Query: 2378 DGKMVPIIPGGNSIPLTFSNRKEYVERAIEYRLHEMDRQV-AAVREGMSWIVPVPLLSLL 2554
            D   V +IP G S+ +  SN+K+YV + ++Y L+   + V    + G   +    +L   
Sbjct: 791  DQNDVDLIPNGISVFVDQSNKKDYVSKCVDYVLNTSVKAVYEEFQRGFYKLFDKEILKHF 850

Query: 2555 TAKQLEQMVCGMPEISVEVLKKVVRYRE-VDEQHQLVQWFWHTLEEFSNEERVLFMRFVS 2731
              ++L + + G  +   E  +K   Y +   E H  +  FW      + +E+  F+ F++
Sbjct: 851  KPEELMRAIIGNTDYDWEQFEKNSIYEQGYHESHPTILMFWKAFHSLTLDEKRKFLFFLT 910

Query: 2732 GRSRLPA-NTADISQRFQIMKVDRPYDSLPTSQTCFFQLRLPPYSSQLVMAERLRYAINN 2908
            G  RL          RF+  +     D  P S TC   L LP YS+   + E L+ AIN+
Sbjct: 911  GNDRLHVKGIQKPGIRFRCPETCSESD-FPKSLTCHNILELPEYSTMKKVKEALQRAINS 969


>ref|XP_002704581.1| PREDICTED: hect domain and RLD 6 isoform 1 [Bos taurus].
          Length = 980

 Score =  156 bits (395), Expect = 1e-37
 Identities = 101/327 (30%), Positives = 174/327 (53%), Gaps = 10/327 (3%)
 Frame = +2

Query: 398  YLWGAGRHGQLAE----AGRNVMVXXXXXXXXXXXXVICGQNCTFVIQANGTVLACGEGS 565
            + W AG    L E    AG N ++               G++ + ++ ++GTV +CG+ S
Sbjct: 3    FCWRAGGRRPLRERQVCAGGNTLLQ-----------AASGEHHSLLLLSDGTVQSCGDNS 51

Query: 566  YGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSDGHSMALTESGEVFSWGDGDYGKLG 745
             G+LG+  +        I AL+   V   + SCG + HS+A+   G VF+WG    G+LG
Sbjct: 52   RGQLGRKGTPRGEQPERIPALETLNVA--LVSCGKE-HSLAVCHKGRVFAWGAASEGQLG 108

Query: 746  HGN-SDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLGLGNT-SN 919
             G   +    P++I+ L G +++Q++CG  HS  ++ DG++F++G   +G+LGLG    +
Sbjct: 109  IGEFKETTFIPKKIKTLAGIKIIQVACGHYHSVALSEDGQVFSWGTNSHGQLGLGKEFPS 168

Query: 920  KKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNSTA---KSSP 1090
            +  P+RV +LEG  + QVA G +H+ A+S  G+  + +G    G+L L  + A   +  P
Sbjct: 169  QASPQRVRSLEGIPLAQVAAGGHHSFALSLSGTS-FGWGSNSAGQLALSGNNAPVQRYKP 227

Query: 1091 QKVDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGLPEGRARNHNRPQQIPVLAG 1270
              +  L  +G+  ++CG + +  LT+DG V+TFG +    L          PQ +  + G
Sbjct: 228  VSIGALKTLGVVSISCGYKHTAVLTQDGKVFTFGDNSYGQLGHDPTAEKRGPQLVERIEG 287

Query: 1271 VVIEDVAVGAEHTLA-LASTGDVYAWG 1348
            +V   +  G++HTLA + +TG V ++G
Sbjct: 288  LV-SQIDCGSDHTLAYIYTTGQVVSFG 313



 Score =  149 bits (376), Expect = 2e-35
 Identities = 97/280 (34%), Positives = 149/280 (53%), Gaps = 5/280 (1%)
 Frame = +2

Query: 650  LVTSCGSDGHSMALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGF 829
            L+ +   + HS+ L   G V S GD   G+LG   + R  +P +I AL+   V  +SCG 
Sbjct: 25   LLQAASGEHHSLLLLSDGTVQSCGDNSRGQLGRKGTPRGEQPERIPALETLNVALVSCGK 84

Query: 830  KHSAVVTSDGKLFTFGNGDYGRLGLGNTSNKK-LPERVTALEGYQIGQVACGLNHTLAVS 1006
            +HS  V   G++F +G    G+LG+G       +P+++  L G +I QVACG  H++A+S
Sbjct: 85   EHSLAVCHKGRVFAWGAASEGQLGIGEFKETTFIPKKIKTLAGIKIIQVACGHYHSVALS 144

Query: 1007 ADGSMVWAFGDGDYGKLGLGNS-TAKSSPQKVDVLCGIGIKKVACGTQFSVALTKDGHVY 1183
             DG  V+++G   +G+LGLG    +++SPQ+V  L GI + +VA G   S AL+  G  +
Sbjct: 145  EDG-QVFSWGTNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGHHSFALSLSGTSF 203

Query: 1184 TFGQDRL--IGLPEGRAR-NHNRPQQIPVLAGVVIEDVAVGAEHTLALASTGDVYAWGSN 1354
             +G +    + L    A     +P  I  L  + +  ++ G +HT  L   G V+ +G N
Sbjct: 204  GWGSNSAGQLALSGNNAPVQRYKPVSIGALKTLGVVSISCGYKHTAVLTQDGKVFTFGDN 263

Query: 1355 SEGQLGLGHTNHVREPTLVTVLQGKNVRQISAGRCHSAAW 1474
            S GQLG   T   R P LV  ++G  V QI  G  H+ A+
Sbjct: 264  SYGQLGHDPTAEKRGPQLVERIEGL-VSQIDCGSDHTLAY 302



 Score =  135 bits (339), Expect = 3e-31
 Identities = 89/244 (36%), Positives = 131/244 (53%), Gaps = 5/244 (2%)
 Frame = +2

Query: 761  RQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLGLGNTSNKKLPERV 940
            R  R RQ+ A  G  ++Q + G  HS ++ SDG + + G+   G+LG   T   + PER+
Sbjct: 11   RPLRERQVCA-GGNTLLQAASGEHHSLLLLSDGTVQSCGDNSRGQLGRKGTPRGEQPERI 69

Query: 941  TALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGN-STAKSSPQKVDVLCGI 1117
             ALE   +  V+CG  H+LAV   G  V+A+G    G+LG+G        P+K+  L GI
Sbjct: 70   PALETLNVALVSCGKEHSLAVCHKG-RVFAWGAASEGQLGIGEFKETTFIPKKIKTLAGI 128

Query: 1118 GIKKVACGTQFSVALTKDGHVYTFGQDRLIGLPEGRA-RNHNRPQQIPVLAGVVIEDVAV 1294
             I +VACG   SVAL++DG V+++G +    L  G+   +   PQ++  L G+ +  VA 
Sbjct: 129  KIIQVACGHYHSVALSEDGQVFSWGTNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAA 188

Query: 1295 GAEHTLALASTGDVYAWGSNSEGQLGLGHTN---HVREPTLVTVLQGKNVRQISAGRCHS 1465
            G  H+ AL+ +G  + WGSNS GQL L   N      +P  +  L+   V  IS G  H+
Sbjct: 189  GGHHSFALSLSGTSFGWGSNSAGQLALSGNNAPVQRYKPVSIGALKTLGVVSISCGYKHT 248

Query: 1466 AAWT 1477
            A  T
Sbjct: 249  AVLT 252



 Score =  118 bits (296), Expect = 3e-26
 Identities = 80/255 (31%), Positives = 122/255 (47%), Gaps = 8/255 (3%)
 Frame = +2

Query: 395  VYLWGAGRHGQLA----EAGRNVMVXXXXXXXXXXXXVICGQNCTFVIQANGTVLACGEG 562
            V+ WGA   GQL     +    +              V CG   +  +  +G V + G  
Sbjct: 96   VFAWGAASEGQLGIGEFKETTFIPKKIKTLAGIKIIQVACGHYHSVALSEDGQVFSWGTN 155

Query: 563  SYGRLGQGNSDDLHVLTV-ISALQGFVVTQLVTSCGSDGHSMALTESGEVFSWGDGDYGK 739
            S+G+LG G           + +L+G  + Q+        HS AL+ SG  F WG    G+
Sbjct: 156  SHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAG---GHHSFALSLSGTSFGWGSNSAGQ 212

Query: 740  L---GHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLGLGN 910
            L   G+    ++ +P  I AL+   VV +SCG+KH+AV+T DGK+FTFG+  YG+LG   
Sbjct: 213  LALSGNNAPVQRYKPVSIGALKTLGVVSISCGYKHTAVLTQDGKVFTFGDNSYGQLGHDP 272

Query: 911  TSNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNSTAKSSP 1090
            T+ K+ P+ V  +EG  + Q+ CG +HTLA       V +FG G     G  + +     
Sbjct: 273  TAEKRGPQLVERIEGL-VSQIDCGSDHTLAYIYTTGQVVSFGRGP----GCASRSPHPGA 327

Query: 1091 QKVDVLCGIGIKKVA 1135
            +  D+ C +  K +A
Sbjct: 328  ESSDISCLVSAKDLA 342



 Score = 60.8 bits (146), Expect = 8e-09
 Identities = 67/283 (23%), Positives = 117/283 (41%), Gaps = 8/283 (2%)
 Frame = +2

Query: 2084 DRFLFNPSACLDEHLMQFKFLGILMGVAIRTKKPLDLHLAPLVWKQLCCVPXXXXXXXXX 2263
            D +++ P     E  M F F G+L G+++     + L     ++K+L             
Sbjct: 701  DSYMWFPVKPKFEKKMYFLF-GMLCGLSLYNFNVVYLPFPLALFKKLLDQEPSLEDLKEL 759

Query: 2264 XXXYVQTLNSILHIEDSGITEE-----SFHEMIPLDSFVGQSADGKMVPIIPGGNSIPLT 2428
               + + L  +L+ + + I EE     S H             D   V +IP G S+ + 
Sbjct: 760  SPSFGKCLQEVLNDDANDIKEEFGLRFSIHW------------DQNDVDLIPNGISVFVD 807

Query: 2429 FSNRKEYVERAIEYRLHEMDRQV-AAVREGMSWIVPVPLLSLLTAKQLEQMVCGMPEISV 2605
             SN+K+YV + ++Y L+   + V    + G   +    +L     ++L + + G  +   
Sbjct: 808  QSNKKDYVSKCVDYVLNTSVKAVYEEFQRGFYKLFDKEILKHFKPEELMRAIIGNTDYDW 867

Query: 2606 EVLKKVVRYRE-VDEQHQLVQWFWHTLEEFSNEERVLFMRFVSGRSRLPA-NTADISQRF 2779
            E  +K   Y +   E H  +  FW      + +E+  F+ F++G  RL          RF
Sbjct: 868  EQFEKNSIYEQGYHESHPTILMFWKAFHSLTLDEKRKFLFFLTGNDRLHVKGIQKPGIRF 927

Query: 2780 QIMKVDRPYDSLPTSQTCFFQLRLPPYSSQLVMAERLRYAINN 2908
            +  +     D  P S TC   L LP YS+   + E L+ AIN+
Sbjct: 928  RCPETCSESD-FPKSLTCHNILELPEYSTMKKVKEALQRAINS 969


>ref|NP_001179920.1| RCC1 and BTB domain-containing protein 2 [Bos taurus].
          Length = 527

 Score =  152 bits (385), Expect = 2e-36
 Identities = 97/289 (33%), Positives = 151/289 (52%), Gaps = 3/289 (1%)
 Frame = +2

Query: 533  NGTVLACGEGSYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSDGHSMALTESGEVF 712
            N  +   G    G LG G+         + +L G  +  L  S GS  H +  T  GEVF
Sbjct: 40   NDEIFVLGTNCCGCLGLGDVQSTIEPRRLDSLSGKKIACL--SYGSGPHIVLATTEGEVF 97

Query: 713  SWGDGDYGKLGHGNSDRQRRPRQIEA-LQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDY 889
            +WG   Y +LG+G ++    P  I   L  ++V++++CG  HS V+TSDG++F +G  + 
Sbjct: 98   TWGHNAYSQLGNGTTNAGLVPYHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWGYNNS 157

Query: 890  GRLGLGNTSNKKLPERVTA-LEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLG 1066
            G++G G+T+N+ +P RVT  L+   +  +ACG   ++AV   G  V+ +G    G+LGLG
Sbjct: 158  GQVGSGSTANQPIPRRVTGCLQSKVVVNIACGQMCSMAVVNTGE-VFVWGYNGNGQLGLG 216

Query: 1067 NSTAKSSPQKVDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGLPEGRARNHNRP 1246
            +S  + +P +V  L GI +++VACG   ++ LT +G VY +G +    L  G   N + P
Sbjct: 217  SSGNQPTPCRVAALQGIRVQRVACGYAHTLVLTDEGQVYAWGANSYGQLGTGNKSNQSYP 276

Query: 1247 QQIPVLAGVVIEDVAVGAEHTLALAST-GDVYAWGSNSEGQLGLGHTNH 1390
              + V    +IE  A  + HT A  +  G VY WG      + L H  H
Sbjct: 277  TPVVVEKDRIIEIAACHSAHTSAAKTQGGHVYMWGQCRGQSVTLPHLTH 325



 Score =  147 bits (370), Expect = 8e-35
 Identities = 94/295 (31%), Positives = 158/295 (53%), Gaps = 3/295 (1%)
 Frame = +2

Query: 605  VLTVISALQGFVVTQLVTSCGSDGHSMALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQI 784
            + ++ S  +  +V Q      +    +  T + E+F  G    G LG G+      PR++
Sbjct: 9    IFSLCSEAELQLVRQACVFGSASNELLYTTVNDEIFVLGTNCCGCLGLGDVQSTIEPRRL 68

Query: 785  EALQGEEVVQMSCGF-KHSAVVTSDGKLFTFGNGDYGRLGLGNTSNKKLPERV-TALEGY 958
            ++L G+++  +S G   H  + T++G++FT+G+  Y +LG G T+   +P  + T L   
Sbjct: 69   DSLSGKKIACLSYGSGPHIVLATTEGEVFTWGHNAYSQLGNGTTNAGLVPYHISTNLSNK 128

Query: 959  QIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNSTAKSSPQKVD-VLCGIGIKKVA 1135
            Q+ +VACG  H+L +++DG  V+A+G  + G++G G++  +  P++V   L    +  +A
Sbjct: 129  QVIEVACGSYHSLVLTSDGE-VFAWGYNNSGQVGSGSTANQPIPRRVTGCLQSKVVVNIA 187

Query: 1136 CGTQFSVALTKDGHVYTFGQDRLIGLPEGRARNHNRPQQIPVLAGVVIEDVAVGAEHTLA 1315
            CG   S+A+   G V+ +G +    L  G + N   P ++  L G+ ++ VA G  HTL 
Sbjct: 188  CGQMCSMAVVNTGEVFVWGYNGNGQLGLGSSGNQPTPCRVAALQGIRVQRVACGYAHTLV 247

Query: 1316 LASTGDVYAWGSNSEGQLGLGHTNHVREPTLVTVLQGKNVRQISAGRCHSAAWTA 1480
            L   G VYAWG+NS GQLG G+ ++   PT V V   +  R I    CHSA  +A
Sbjct: 248  LTDEGQVYAWGANSYGQLGTGNKSNQSYPTPVVV---EKDRIIEIAACHSAHTSA 299



 Score =  114 bits (286), Expect = 5e-25
 Identities = 73/220 (33%), Positives = 112/220 (50%), Gaps = 5/220 (2%)
 Frame = +2

Query: 392  DVYLWGAGRHGQLAEAGRNV-MVXXXXXXXXXXXXVI---CGQNCTFVIQANGTVLACGE 559
            +V+ WG   + QL     N  +V            VI   CG   + V+ ++G V A G 
Sbjct: 95   EVFTWGHNAYSQLGNGTTNAGLVPYHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWGY 154

Query: 560  GSYGRLGQGNSDDLHV-LTVISALQGFVVTQLVTSCGSDGHSMALTESGEVFSWGDGDYG 736
             + G++G G++ +  +   V   LQ  VV  +  +CG    SMA+  +GEVF WG    G
Sbjct: 155  NNSGQVGSGSTANQPIPRRVTGCLQSKVVVNI--ACGQMC-SMAVVNTGEVFVWGYNGNG 211

Query: 737  KLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLGLGNTS 916
            +LG G+S  Q  P ++ ALQG  V +++CG+ H+ V+T +G+++ +G   YG+LG GN S
Sbjct: 212  QLGLGSSGNQPTPCRVAALQGIRVQRVACGYAHTLVLTDEGQVYAWGANSYGQLGTGNKS 271

Query: 917  NKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFG 1036
            N+  P  V   +   I   AC   HT A    G  V+ +G
Sbjct: 272  NQSYPTPVVVEKDRIIEIAACHSAHTSAAKTQGGHVYMWG 311


  Database: RefSeq49_BP.fasta
    Posted date:  Oct 17, 2011  1:42 PM
  Number of letters in database: 17,681,374
  Number of sequences in database:  33,088
  
Lambda     K      H
   0.318    0.134    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 33088
Number of Hits to DB: 135,095,240
Number of extensions: 3679909
Number of successful extensions: 12916
Number of sequences better than 1.0e-05: 65
Number of HSP's gapped: 12171
Number of HSP's successfully gapped: 187
Length of query: 1168
Length of database: 17,681,374
Length adjustment: 113
Effective length of query: 1055
Effective length of database: 13,942,430
Effective search space: 14709263650
Effective search space used: 14709263650
Neighboring words threshold: 12
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 36 (18.5 bits)

BLASTX 2.2.24 [Aug-08-2010]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= 20110601C-003115
         (3506 letters)

Database: RefSeq49_CP.fasta 
           33,336 sequences; 18,874,504 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

Alignment   gi|XP_544717.2| PREDICTED: similar to guanine nucleotide exchan...  1972   0.0  
Alignment   gi|XP_867304.1| PREDICTED: similar to hect domain and RLD 2 iso...   645   0.0  
Alignment   gi|XP_536160.2| PREDICTED: similar to hect domain and RLD 2 iso...   645   0.0  
Alignment   gi|XP_865375.1| PREDICTED: similar to guanine nucleotide exchan...   547   e-155
Alignment   gi|XP_853300.1| PREDICTED: similar to guanine nucleotide exchan...   244   5e-64
Alignment   gi|XP_539635.2| PREDICTED: similar to HECT domain containing 3 ...   189   1e-47
Alignment   gi|XP_535653.2| PREDICTED: similar to HECT domain and RCC1-like...   174   7e-43
Alignment   gi|XP_860006.1| PREDICTED: similar to hect domain and RLD 4 iso...   162   2e-39
Alignment   gi|XP_536367.2| PREDICTED: similar to hect domain and RLD 4 iso...   160   6e-39
Alignment   gi|XP_860046.1| PREDICTED: similar to hect domain and RLD 4 iso...   160   6e-39

>ref|XP_544717.2| PREDICTED: similar to guanine nucleotide exchange factor p532 isoform
            1 [Canis familiaris].
          Length = 4168

 Score = 1972 bits (5110), Expect = 0.0
 Identities = 965/994 (97%), Positives = 970/994 (97%)
 Frame = +2

Query: 2    EKPHVVCGDQLVHSPYMQCLASLAVGLHLDQLLCNPPVPPHHQNCLPDPASWNPNEWAWL 181
            EKPHVVCGDQLVHSPYMQCLASLAVGLHLDQLLCNPPVPPHHQNCLPDPASWNPNEWAWL
Sbjct: 3175 EKPHVVCGDQLVHSPYMQCLASLAVGLHLDQLLCNPPVPPHHQNCLPDPASWNPNEWAWL 3234

Query: 182  ECFSTTIKAAEALTNGAQFPESFSVPDLEPVPEDELVFLMDNSKWINGMDEQIMSWATSR 361
            ECFSTTIKAAEALTNGAQFPESF+VPDLEPVPEDEL+FLMDNSKWINGMDEQIMSWATSR
Sbjct: 3235 ECFSTTIKAAEALTNGAQFPESFTVPDLEPVPEDELLFLMDNSKWINGMDEQIMSWATSR 3294

Query: 362  PEDWHLGGKCDVYLWGAGRHGQLAEAGRNVMVXXXXXXXXXXXXVICGQNCTFVIQANGT 541
            PEDWHLGGKCDVYLWGAGRHGQLAEAGRNVMV            VICGQNCTFVIQANGT
Sbjct: 3295 PEDWHLGGKCDVYLWGAGRHGQLAEAGRNVMVPAAAPSFSQAQQVICGQNCTFVIQANGT 3354

Query: 542  VLACGEGSYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSDGHSMALTESGEVFSWG 721
            VLACGEGSYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSDGHSMALTESGEVFSWG
Sbjct: 3355 VLACGEGSYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSDGHSMALTESGEVFSWG 3414

Query: 722  DGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLG 901
            DGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLG
Sbjct: 3415 DGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLG 3474

Query: 902  LGNTSNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNSTAK 1081
            LGNTSNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNSTAK
Sbjct: 3475 LGNTSNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNSTAK 3534

Query: 1082 SSPQKVDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGLPEGRARNHNRPQQIPV 1261
            SSPQKVDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGLPEGRARNHNRPQQIPV
Sbjct: 3535 SSPQKVDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGLPEGRARNHNRPQQIPV 3594

Query: 1262 LAGVVIEDVAVGAEHTLALASTGDVYAWGSNSEGQLGLGHTNHVREPTLVTVLQGKNVRQ 1441
            LAGVVIEDVAVGAEHTLALASTGDVYAWGSNSEGQLGLGHTNHVREPTLVTVLQGKN+RQ
Sbjct: 3595 LAGVVIEDVAVGAEHTLALASTGDVYAWGSNSEGQLGLGHTNHVREPTLVTVLQGKNIRQ 3654

Query: 1442 ISAGRCHSAAWTAPPVPPRAPGVSVPLQLGLPDAVPPQYGALREVSIHTARARLRLLYHF 1621
            ISAGRCHSAAWTAPPVPPRAPGVSVPLQLGLPDAVPPQYGALREVSIHTARARLRLLYHF
Sbjct: 3655 ISAGRCHSAAWTAPPVPPRAPGVSVPLQLGLPDAVPPQYGALREVSIHTARARLRLLYHF 3714

Query: 1622 SDLMYSSWRLLNLSPNNQNSTSHYNAGTWGIVQGQLRPLLAPRVYTLPMVRSIGKTMVQG 1801
            SDLMYSSWRLLNLSPNNQ+STSHYNAGTWGIVQGQLRPLLAPRVYTLPMVRSIGKTMVQG
Sbjct: 3715 SDLMYSSWRLLNLSPNNQSSTSHYNAGTWGIVQGQLRPLLAPRVYTLPMVRSIGKTMVQG 3774

Query: 1802 KNYGPQITVKRISTRGRKCKPIFVQIARQVVKLNASDLRLPSRAWKVKLVGEGADDAGGV 1981
            KNYGPQITVKRISTRGRKCKPIFVQIARQVVKLNASDLRLPSRAWKVKLVGEGADDAGGV
Sbjct: 3775 KNYGPQITVKRISTRGRKCKPIFVQIARQVVKLNASDLRLPSRAWKVKLVGEGADDAGGV 3834

Query: 1982 FDDTITEMCQELETGIVDLLIPSPNATAEVGYNRDRFLFNPSACLDEHLMQFKFLGILMG 2161
            FDDTITEMCQELETGIVDLLIPSPNATAEVGYNRDRFLFNPSACLDEHLMQFKFLGILMG
Sbjct: 3835 FDDTITEMCQELETGIVDLLIPSPNATAEVGYNRDRFLFNPSACLDEHLMQFKFLGILMG 3894

Query: 2162 VAIRTKKPLDLHLAPLVWKQLCCVPXXXXXXXXXXXXYVQTLNSILHIEDSGITEESFHE 2341
            VAIRTKKPLDLHLAPLVWKQLCCVP            YVQTLNSILHIEDSGITEESFHE
Sbjct: 3895 VAIRTKKPLDLHLAPLVWKQLCCVPLTLEDLEEVDLLYVQTLNSILHIEDSGITEESFHE 3954

Query: 2342 MIPLDSFVGQSADGKMVPIIPGGNSIPLTFSNRKEYVERAIEYRLHEMDRQVAAVREGMS 2521
            MIPLDSF+GQSADGKMVPIIPGGNSIPLTFSNRKEYVERAIEYRLHEMDRQVAAVREGMS
Sbjct: 3955 MIPLDSFIGQSADGKMVPIIPGGNSIPLTFSNRKEYVERAIEYRLHEMDRQVAAVREGMS 4014

Query: 2522 WIVPVPLLSLLTAKQLEQMVCGMPEISVEVLKKVVRYREVDEQHQLVQWFWHTLEEFSNE 2701
            WIVPVPLLSLLTAKQLEQMVCGMPEISVEVLKKVVRYREVDEQHQLVQWFWHTLEEFSNE
Sbjct: 4015 WIVPVPLLSLLTAKQLEQMVCGMPEISVEVLKKVVRYREVDEQHQLVQWFWHTLEEFSNE 4074

Query: 2702 ERVLFMRFVSGRSRLPANTADISQRFQIMKVDRPYDSLPTSQTCFFQLRLPPYSSQLVMA 2881
            ERVLFMRFVSGRSRLPANTADISQRFQIMKVDRPYDSLPTSQTCFFQLRLPPYSSQLVMA
Sbjct: 4075 ERVLFMRFVSGRSRLPANTADISQRFQIMKVDRPYDSLPTSQTCFFQLRLPPYSSQLVMA 4134

Query: 2882 ERLRYAINNCRSIDMDNYMLSRNVDNAEGSDTDY 2983
            ERLRYAINNCRSIDMDNYMLSRNVDNAEGSDTDY
Sbjct: 4135 ERLRYAINNCRSIDMDNYMLSRNVDNAEGSDTDY 4168


>ref|XP_867304.1| PREDICTED: similar to hect domain and RLD 2 isoform 2 [Canis
            familiaris].
          Length = 2124

 Score =  645 bits (1665), Expect = 0.0
 Identities = 390/1007 (38%), Positives = 545/1007 (54%), Gaps = 29/1007 (2%)
 Frame = +2

Query: 2    EKPHVVCGDQLVHSPYMQCLASLAVGLHLDQLLCNPPVPPHHQNCLPDPASWNPNEWAWL 181
            E P V  G QL+HSP+ + L +LA  L LD L C          C         ++WAW 
Sbjct: 1121 EDPIVRGGKQLLHSPFFKVLVALACDLELDTLPC----------CA------ETHKWAWF 1164

Query: 182  ECFSTTIKAAEALTNGAQFPESF------SVPDLEPVPEDELVFLMDNSKWINGMDEQIM 343
              +    + A AL      P  F       + +L    E   V    +  +    DEQ++
Sbjct: 1165 RRYCMASRVAVALDKRTPLPRLFLDEVAKKIRELMADSEHMDVLHESHDIFKREQDEQLV 1224

Query: 344  SWATSRPEDWHL--GGKCDVYLWGAGRHGQLAEA-GRNVMVXXXXXXXXXXXXV--ICGQ 508
             W   RP+DW L  GG   +Y WG    GQL    G  V V            V  I G+
Sbjct: 1225 QWMNRRPDDWTLSAGGSGTIYGWGHNHRGQLGGIEGAKVKVPTPCEALATLRPVQLIGGE 1284

Query: 509  NCTFVIQANGTVLACGEGSYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSDGHSMA 688
               F + A+G + A G G+ GRLG G ++ +   T++ ++Q   + ++  + G   H +A
Sbjct: 1285 QTLFAVTADGKLYATGYGAGGRLGIGGTESVSTPTLLESIQHVFIKKVAVNSGGK-HCLA 1343

Query: 689  LTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLF 868
            L+  GEV+SWG+ + GKLGHGN     RPR IE+L+G EVV ++ G  HSA VT+ G L+
Sbjct: 1344 LSSEGEVYSWGEAEDGKLGHGNRSPCDRPRVIESLRGIEVVDVAAGGAHSACVTAAGDLY 1403

Query: 869  TFGNGDYGRLGLGNTSNKKLPERVTALEGYQIGQVACGLN--HTLAVSADGSMVWAFGDG 1042
            T+G G YGRLG  ++ ++  P+ V AL+G+++  VACG     TL ++ D + VW++GDG
Sbjct: 1404 TWGKGRYGRLGHSDSEDQLKPKLVEALQGHRVVDVACGSGDAQTLCLTDDDT-VWSWGDG 1462

Query: 1043 DYGKLGLGNSTAKSSPQKVDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGLPEG 1222
            DYGKLG G S     P K+D L G+G+ KV CG+QFSVALTK G VYT+G+     L  G
Sbjct: 1463 DYGKLGRGGSDGCKVPMKIDSLTGLGVVKVECGSQFSVALTKSGAVYTWGKGDYHRLGHG 1522

Query: 1223 RARNHNRPQQIPVLAGVVIEDVAVGAEHTLALASTGDVYAWGSNSEGQLGLGHTNHVREP 1402
               +  RP+Q+  L G  +  +A G+ H +     G+VY WG N EGQLG G TN ++ P
Sbjct: 1523 SDDHVRRPRQVQGLQGKKVIAIATGSLHCVCCTEDGEVYTWGDNDEGQLGDGTTNAIQRP 1582

Query: 1403 TLVTVLQGKNVRQISAGRCHSAAWTAPPVPPRAPGVSVPLQLG-LPDAVPPQYGALREVS 1579
             LV  LQGK V +++ G  H+ AW+           S P   G LP  VP +Y  L+E+ 
Sbjct: 1583 RLVAALQGKKVNRVACGSAHTLAWS----------TSKPASAGKLPAQVPMEYNHLQEIP 1632

Query: 1580 IHTARARLRLLYHFSDLMYSSWRLLNLSPNNQNSTSHYNAGTWGIVQGQLRPLLAPRVYT 1759
            I   R RL LL+H S+L      + +L    + S      G   +    LR +L  +   
Sbjct: 1633 IIALRNRLLLLHHISELFCPCIPMFDL----EGSLDETGLGP-SVGFDTLRGILISQGKE 1687

Query: 1760 LPMVRSIGKTMVQGKNYGPQITVKRISTRGRK----------CKPIFVQIARQVVKLNAS 1909
                + +  TMV+ + +GP + + RI  +  +           K +F Q+  ++   +  
Sbjct: 1688 AAFRKVVQATMVRDRQHGPVVELNRIQVKRSRSKGGLAGPDGTKSVFGQMCAKMSSFSPD 1747

Query: 1910 DLRLPSRAWKVKLVGEGADDAGGVFDDTITEMCQELETGIVDLLIPSPNATAEVGYNRDR 2089
             L LP R WKVK VGE  DD GG + ++I E+C+EL+ G+  LLI +PN   E G NRD 
Sbjct: 1748 SLLLPHRVWKVKFVGESVDDCGGGYSESIAEICEELQNGLTPLLIVTPNGRDESGANRDC 1807

Query: 2090 FLFNPSACLDEHLMQFKFLGILMGVAIRTKKPLDLHLAPLVWKQLCCVPXXXXXXXXXXX 2269
            +LF+P+A    H   F+FLG+L+G+AIRT  PL L+LA  VWKQL  +            
Sbjct: 1808 YLFSPAARAPVHTNMFRFLGVLLGIAIRTGSPLSLNLAEPVWKQLAGMSLTIADLSEVDK 1867

Query: 2270 XYVQTLNSILHIEDSGITEESFHEM-IPLDSFVGQSADGKMVPIIPGGNSIPLTFSNRKE 2446
             ++     +++I D+  T E F  M +P   F   SA G+ + +        +T  NR E
Sbjct: 1868 DFIP---GLMYIRDNEATSEEFEAMSLP---FTVPSASGQDIQL--SSKYTHITLDNRAE 1919

Query: 2447 YVERAIEYRLHEMDRQVAAVREGMSWIVPVPLLSLLTAKQLEQMVCGMPEISVEVLKKVV 2626
            YV  AI YRLHE D QVAAVREGM+ +VPVPLLSL T  +LE MVCG P+I + +LK V 
Sbjct: 1920 YVRLAINYRLHEFDEQVAAVREGMARVVPVPLLSLFTGYELETMVCGSPDIPLHLLKSVA 1979

Query: 2627 RYREVDEQHQLVQWFWHTLEEFSNEERVLFMRFVSGRSRLPANTADISQR-FQIMKVDR- 2800
             Y+ ++    L+QWFW  +E FSN ER LF+RFV GR+RLP   AD   R F I  +D+ 
Sbjct: 1980 TYKGIEPSASLIQWFWEVMESFSNTERSLFLRFVWGRTRLPRTIADFRGRDFVIQVLDKY 2039

Query: 2801 --PYDSLPTSQTCFFQLRLPPYSSQLVMAERLRYAINNCRSIDMDNY 2935
              P   LP S TCFF L+LP YS + V+ E+L+YAI+ C+SID D+Y
Sbjct: 2040 NPPDHFLPESYTCFFLLKLPRYSCKQVLEEKLKYAIHFCKSIDTDDY 2086



 Score =  263 bits (671), Expect = 1e-69
 Identities = 146/343 (42%), Positives = 208/343 (60%), Gaps = 3/343 (0%)
 Frame = +2

Query: 503  GQNCTFVIQANGTVLACGEGSYGRLGQG-NSDDLHVLTVISALQGFVVTQLVTSCGSDGH 679
            G    F +   G V ACGE + GRLG G +S  + +   I+AL  +VV ++    G   H
Sbjct: 288  GSKSLFAVTVEGKVYACGEATNGRLGLGLSSGTVPIPRQITALSSYVVKKVAVHSGGR-H 346

Query: 680  SMALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDG 859
            + ALT  G+VFSWG+GD GKLGH +     +PR IEAL+ + +  ++CG  HSA +TS G
Sbjct: 347  ATALTVDGKVFSWGEGDDGKLGHFSRMNCDKPRLIEALKTKRIRDIACGSSHSAALTSSG 406

Query: 860  KLFTFGNGDYGRLGLGNTSNKKLPERVTALEGYQIGQVACGLN--HTLAVSADGSMVWAF 1033
            +L+T+G G+YGRLG G+ + +  P+ V  L G+++ QVACG     TLA++ +G +V+++
Sbjct: 407  ELYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEG-LVFSW 465

Query: 1034 GDGDYGKLGLGNSTAKSSPQKVDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGL 1213
            GDGD+GKLG G S   + PQ ++ L G G+ ++ CG QFS+ALTK G V+T+G+     L
Sbjct: 466  GDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFSLALTKSGVVWTWGKGDYFRL 525

Query: 1214 PEGRARNHNRPQQIPVLAGVVIEDVAVGAEHTLALASTGDVYAWGSNSEGQLGLGHTNHV 1393
              G   +  +PQ +  L G  I  VAVGA H LA+   G VYAWG N  GQ G G T   
Sbjct: 526  GHGSDVHVRKPQVVEGLRGKKIVHVAVGALHCLAVTDAGQVYAWGDNDHGQQGNGTTTVN 585

Query: 1394 REPTLVTVLQGKNVRQISAGRCHSAAWTAPPVPPRAPGVSVPL 1522
            R+PTLV  L+G+ + +++ G  HS AWT   +    P V  P+
Sbjct: 586  RKPTLVQGLEGQKITRVACGSSHSVAWTT--IDVATPSVHEPV 626



 Score =  166 bits (421), Expect = 1e-40
 Identities = 100/261 (38%), Positives = 142/261 (54%), Gaps = 4/261 (1%)
 Frame = +2

Query: 395  VYLWGAGRHGQLAEAGR---NVMVXXXXXXXXXXXXVICGQNCTFVIQANGTVLACGEGS 565
            V+ WG G  G+L    R   +               + CG + +  + ++G +   G G 
Sbjct: 356  VFSWGEGDDGKLGHFSRMNCDKPRLIEALKTKRIRDIACGSSHSAALTSSGELYTWGLGE 415

Query: 566  YGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGS-DGHSMALTESGEVFSWGDGDYGKL 742
            YGRLG G++       ++  L G  V Q+  +CGS D  ++ALT+ G VFSWGDGD+GKL
Sbjct: 416  YGRLGHGDNTTQLKPKMVKVLLGHRVIQV--ACGSRDAQTLALTDEGLVFSWGDGDFGKL 473

Query: 743  GHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLGLGNTSNK 922
            G G S+    P+ IE L G+ V Q+ CG + S  +T  G ++T+G GDY RLG G+  + 
Sbjct: 474  GRGGSEGCNIPQNIERLNGQGVCQIECGAQFSLALTKSGVVWTWGKGDYFRLGHGSDVHV 533

Query: 923  KLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNSTAKSSPQKVD 1102
            + P+ V  L G +I  VA G  H LAV+ D   V+A+GD D+G+ G G +T    P  V 
Sbjct: 534  RKPQVVEGLRGKKIVHVAVGALHCLAVT-DAGQVYAWGDNDHGQQGNGTTTVNRKPTLVQ 592

Query: 1103 VLCGIGIKKVACGTQFSVALT 1165
             L G  I +VACG+  SVA T
Sbjct: 593  GLEGQKITRVACGSSHSVAWT 613



 Score =  138 bits (347), Expect = 4e-32
 Identities = 95/273 (34%), Positives = 136/273 (49%), Gaps = 5/273 (1%)
 Frame = +2

Query: 674  GHSMALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTS 853
            G   A T   +VF WG  D  +LG     + + P   E L    VVQ++ G K    VT 
Sbjct: 238  GLESAATIRTKVFVWGLNDKDQLGGLKGSKIKVPSFSETLSALNVVQVAGGSKSLFAVTV 297

Query: 854  DGKLFTFGNGDYGRLGLGNTSNK-KLPERVTALEGYQIGQVA--CGLNHTLAVSADGSMV 1024
            +GK++  G    GRLGLG +S    +P ++TAL  Y + +VA   G  H  A++ DG  V
Sbjct: 298  EGKVYACGEATNGRLGLGLSSGTVPIPRQITALSSYVVKKVAVHSGGRHATALTVDGK-V 356

Query: 1025 WAFGDGDYGKLGLGNSTAKSSPQKVDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRL 1204
            +++G+GD GKLG  +      P+ ++ L    I+ +ACG+  S ALT  G +YT+G    
Sbjct: 357  FSWGEGDDGKLGHFSRMNCDKPRLIEALKTKRIRDIACGSSHSAALTSSGELYTWGLGEY 416

Query: 1205 IGLPEGRARNHNRPQQIPVLAGVVIEDVAVGAE--HTLALASTGDVYAWGSNSEGQLGLG 1378
              L  G      +P+ + VL G  +  VA G+    TLAL   G V++WG    G+LG G
Sbjct: 417  GRLGHGDNTTQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFSWGDGDFGKLGRG 476

Query: 1379 HTNHVREPTLVTVLQGKNVRQISAGRCHSAAWT 1477
             +     P  +  L G+ V QI  G   S A T
Sbjct: 477  GSEGCNIPQNIERLNGQGVCQIECGAQFSLALT 509


>ref|XP_536160.2| PREDICTED: similar to hect domain and RLD 2 isoform 1 [Canis
            familiaris].
          Length = 4837

 Score =  645 bits (1665), Expect = 0.0
 Identities = 390/1007 (38%), Positives = 545/1007 (54%), Gaps = 29/1007 (2%)
 Frame = +2

Query: 2    EKPHVVCGDQLVHSPYMQCLASLAVGLHLDQLLCNPPVPPHHQNCLPDPASWNPNEWAWL 181
            E P V  G QL+HSP+ + L +LA  L LD L C          C         ++WAW 
Sbjct: 3834 EDPIVRGGKQLLHSPFFKVLVALACDLELDTLPC----------CA------ETHKWAWF 3877

Query: 182  ECFSTTIKAAEALTNGAQFPESF------SVPDLEPVPEDELVFLMDNSKWINGMDEQIM 343
              +    + A AL      P  F       + +L    E   V    +  +    DEQ++
Sbjct: 3878 RRYCMASRVAVALDKRTPLPRLFLDEVAKKIRELMADSEHMDVLHESHDIFKREQDEQLV 3937

Query: 344  SWATSRPEDWHL--GGKCDVYLWGAGRHGQLAEA-GRNVMVXXXXXXXXXXXXV--ICGQ 508
             W   RP+DW L  GG   +Y WG    GQL    G  V V            V  I G+
Sbjct: 3938 QWMNRRPDDWTLSAGGSGTIYGWGHNHRGQLGGIEGAKVKVPTPCEALATLRPVQLIGGE 3997

Query: 509  NCTFVIQANGTVLACGEGSYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSDGHSMA 688
               F + A+G + A G G+ GRLG G ++ +   T++ ++Q   + ++  + G   H +A
Sbjct: 3998 QTLFAVTADGKLYATGYGAGGRLGIGGTESVSTPTLLESIQHVFIKKVAVNSGGK-HCLA 4056

Query: 689  LTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLF 868
            L+  GEV+SWG+ + GKLGHGN     RPR IE+L+G EVV ++ G  HSA VT+ G L+
Sbjct: 4057 LSSEGEVYSWGEAEDGKLGHGNRSPCDRPRVIESLRGIEVVDVAAGGAHSACVTAAGDLY 4116

Query: 869  TFGNGDYGRLGLGNTSNKKLPERVTALEGYQIGQVACGLN--HTLAVSADGSMVWAFGDG 1042
            T+G G YGRLG  ++ ++  P+ V AL+G+++  VACG     TL ++ D + VW++GDG
Sbjct: 4117 TWGKGRYGRLGHSDSEDQLKPKLVEALQGHRVVDVACGSGDAQTLCLTDDDT-VWSWGDG 4175

Query: 1043 DYGKLGLGNSTAKSSPQKVDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGLPEG 1222
            DYGKLG G S     P K+D L G+G+ KV CG+QFSVALTK G VYT+G+     L  G
Sbjct: 4176 DYGKLGRGGSDGCKVPMKIDSLTGLGVVKVECGSQFSVALTKSGAVYTWGKGDYHRLGHG 4235

Query: 1223 RARNHNRPQQIPVLAGVVIEDVAVGAEHTLALASTGDVYAWGSNSEGQLGLGHTNHVREP 1402
               +  RP+Q+  L G  +  +A G+ H +     G+VY WG N EGQLG G TN ++ P
Sbjct: 4236 SDDHVRRPRQVQGLQGKKVIAIATGSLHCVCCTEDGEVYTWGDNDEGQLGDGTTNAIQRP 4295

Query: 1403 TLVTVLQGKNVRQISAGRCHSAAWTAPPVPPRAPGVSVPLQLG-LPDAVPPQYGALREVS 1579
             LV  LQGK V +++ G  H+ AW+           S P   G LP  VP +Y  L+E+ 
Sbjct: 4296 RLVAALQGKKVNRVACGSAHTLAWS----------TSKPASAGKLPAQVPMEYNHLQEIP 4345

Query: 1580 IHTARARLRLLYHFSDLMYSSWRLLNLSPNNQNSTSHYNAGTWGIVQGQLRPLLAPRVYT 1759
            I   R RL LL+H S+L      + +L    + S      G   +    LR +L  +   
Sbjct: 4346 IIALRNRLLLLHHISELFCPCIPMFDL----EGSLDETGLGP-SVGFDTLRGILISQGKE 4400

Query: 1760 LPMVRSIGKTMVQGKNYGPQITVKRISTRGRK----------CKPIFVQIARQVVKLNAS 1909
                + +  TMV+ + +GP + + RI  +  +           K +F Q+  ++   +  
Sbjct: 4401 AAFRKVVQATMVRDRQHGPVVELNRIQVKRSRSKGGLAGPDGTKSVFGQMCAKMSSFSPD 4460

Query: 1910 DLRLPSRAWKVKLVGEGADDAGGVFDDTITEMCQELETGIVDLLIPSPNATAEVGYNRDR 2089
             L LP R WKVK VGE  DD GG + ++I E+C+EL+ G+  LLI +PN   E G NRD 
Sbjct: 4461 SLLLPHRVWKVKFVGESVDDCGGGYSESIAEICEELQNGLTPLLIVTPNGRDESGANRDC 4520

Query: 2090 FLFNPSACLDEHLMQFKFLGILMGVAIRTKKPLDLHLAPLVWKQLCCVPXXXXXXXXXXX 2269
            +LF+P+A    H   F+FLG+L+G+AIRT  PL L+LA  VWKQL  +            
Sbjct: 4521 YLFSPAARAPVHTNMFRFLGVLLGIAIRTGSPLSLNLAEPVWKQLAGMSLTIADLSEVDK 4580

Query: 2270 XYVQTLNSILHIEDSGITEESFHEM-IPLDSFVGQSADGKMVPIIPGGNSIPLTFSNRKE 2446
             ++     +++I D+  T E F  M +P   F   SA G+ + +        +T  NR E
Sbjct: 4581 DFIP---GLMYIRDNEATSEEFEAMSLP---FTVPSASGQDIQL--SSKYTHITLDNRAE 4632

Query: 2447 YVERAIEYRLHEMDRQVAAVREGMSWIVPVPLLSLLTAKQLEQMVCGMPEISVEVLKKVV 2626
            YV  AI YRLHE D QVAAVREGM+ +VPVPLLSL T  +LE MVCG P+I + +LK V 
Sbjct: 4633 YVRLAINYRLHEFDEQVAAVREGMARVVPVPLLSLFTGYELETMVCGSPDIPLHLLKSVA 4692

Query: 2627 RYREVDEQHQLVQWFWHTLEEFSNEERVLFMRFVSGRSRLPANTADISQR-FQIMKVDR- 2800
             Y+ ++    L+QWFW  +E FSN ER LF+RFV GR+RLP   AD   R F I  +D+ 
Sbjct: 4693 TYKGIEPSASLIQWFWEVMESFSNTERSLFLRFVWGRTRLPRTIADFRGRDFVIQVLDKY 4752

Query: 2801 --PYDSLPTSQTCFFQLRLPPYSSQLVMAERLRYAINNCRSIDMDNY 2935
              P   LP S TCFF L+LP YS + V+ E+L+YAI+ C+SID D+Y
Sbjct: 4753 NPPDHFLPESYTCFFLLKLPRYSCKQVLEEKLKYAIHFCKSIDTDDY 4799



 Score =  263 bits (671), Expect = 1e-69
 Identities = 146/343 (42%), Positives = 208/343 (60%), Gaps = 3/343 (0%)
 Frame = +2

Query: 503  GQNCTFVIQANGTVLACGEGSYGRLGQG-NSDDLHVLTVISALQGFVVTQLVTSCGSDGH 679
            G    F +   G V ACGE + GRLG G +S  + +   I+AL  +VV ++    G   H
Sbjct: 3001 GSKSLFAVTVEGKVYACGEATNGRLGLGLSSGTVPIPRQITALSSYVVKKVAVHSGGR-H 3059

Query: 680  SMALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDG 859
            + ALT  G+VFSWG+GD GKLGH +     +PR IEAL+ + +  ++CG  HSA +TS G
Sbjct: 3060 ATALTVDGKVFSWGEGDDGKLGHFSRMNCDKPRLIEALKTKRIRDIACGSSHSAALTSSG 3119

Query: 860  KLFTFGNGDYGRLGLGNTSNKKLPERVTALEGYQIGQVACGLN--HTLAVSADGSMVWAF 1033
            +L+T+G G+YGRLG G+ + +  P+ V  L G+++ QVACG     TLA++ +G +V+++
Sbjct: 3120 ELYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEG-LVFSW 3178

Query: 1034 GDGDYGKLGLGNSTAKSSPQKVDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGL 1213
            GDGD+GKLG G S   + PQ ++ L G G+ ++ CG QFS+ALTK G V+T+G+     L
Sbjct: 3179 GDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFSLALTKSGVVWTWGKGDYFRL 3238

Query: 1214 PEGRARNHNRPQQIPVLAGVVIEDVAVGAEHTLALASTGDVYAWGSNSEGQLGLGHTNHV 1393
              G   +  +PQ +  L G  I  VAVGA H LA+   G VYAWG N  GQ G G T   
Sbjct: 3239 GHGSDVHVRKPQVVEGLRGKKIVHVAVGALHCLAVTDAGQVYAWGDNDHGQQGNGTTTVN 3298

Query: 1394 REPTLVTVLQGKNVRQISAGRCHSAAWTAPPVPPRAPGVSVPL 1522
            R+PTLV  L+G+ + +++ G  HS AWT   +    P V  P+
Sbjct: 3299 RKPTLVQGLEGQKITRVACGSSHSVAWTT--IDVATPSVHEPV 3339



 Score =  209 bits (533), Expect = 1e-53
 Identities = 129/343 (37%), Positives = 194/343 (56%), Gaps = 20/343 (5%)
 Frame = +2

Query: 512  CTFVIQANGTVLACGEGSYGRLGQG--------NSDDLHVLTVISALQGFVVTQLVT-SC 664
            C  +     T +AC E  +  L +         NSD L    V    QG     +V  + 
Sbjct: 446  CEGLANLGVTQIACAEKRFLILSRNGRVYTQAYNSDTLAPQLV----QGLASRNIVKIAA 501

Query: 665  GSDGHS-MALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEE----VVQMSCGF 829
             SDGH  +AL  +GEV+SWG GD G+LGHG++     P+ I A  G++    VV ++CG 
Sbjct: 502  HSDGHHYLALAATGEVYSWGCGDGGRLGHGDTVPLEEPKVISAFSGKQAGKHVVHIACGS 561

Query: 830  KHSAVVTSDGKLFTFGNGDYGRLGLGNTSNKKLPERVTALEGYQIGQVACGLN--HTLAV 1003
             +SA +T++G+L+T+G G+YGRLG G++ ++ +P  V  L+G ++  VACG     TLAV
Sbjct: 562  TYSAAITAEGELYTWGRGNYGRLGHGSSEDEAIPMLVAGLKGLKVIDVACGSGDAQTLAV 621

Query: 1004 SADGSMVWAFGDGDYGKLGLGNSTAKSSPQKVDVLCGIGIKKVACGTQFSVALTKDGHVY 1183
            + +G  VW++GDGDYGKLG G S    +P+ ++ L  + + KV CG+QFS+ALTKDG VY
Sbjct: 622  TENGQ-VWSWGDGDYGKLGRGGSDGCKTPKLIEKLQDLDVVKVRCGSQFSIALTKDGQVY 680

Query: 1184 TFGQDRLIGLPEGRARNHNRPQQIPVLAGVVIEDVAVGAEHTLALASTGDVYAWGSNSEG 1363
            ++G+     L  G   +   P+ +  L G  + DVA G+ H LAL    +V++WGSN + 
Sbjct: 681  SWGKGDNQRLGHGTEEHVRYPKLLEGLQGKKVIDVAAGSTHCLALTEDSEVHSWGSNDQC 740

Query: 1364 QLGLGHTNHVR----EPTLVTVLQGKNVRQISAGRCHSAAWTA 1480
            Q    H + +R    EP  +  L  K++  I+ G   S AW++
Sbjct: 741  Q----HFDTLRVTKPEPAALPGLDTKHIVGIACGPAQSFAWSS 779



 Score =  166 bits (421), Expect = 1e-40
 Identities = 100/261 (38%), Positives = 142/261 (54%), Gaps = 4/261 (1%)
 Frame = +2

Query: 395  VYLWGAGRHGQLAEAGR---NVMVXXXXXXXXXXXXVICGQNCTFVIQANGTVLACGEGS 565
            V+ WG G  G+L    R   +               + CG + +  + ++G +   G G 
Sbjct: 3069 VFSWGEGDDGKLGHFSRMNCDKPRLIEALKTKRIRDIACGSSHSAALTSSGELYTWGLGE 3128

Query: 566  YGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGS-DGHSMALTESGEVFSWGDGDYGKL 742
            YGRLG G++       ++  L G  V Q+  +CGS D  ++ALT+ G VFSWGDGD+GKL
Sbjct: 3129 YGRLGHGDNTTQLKPKMVKVLLGHRVIQV--ACGSRDAQTLALTDEGLVFSWGDGDFGKL 3186

Query: 743  GHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLGLGNTSNK 922
            G G S+    P+ IE L G+ V Q+ CG + S  +T  G ++T+G GDY RLG G+  + 
Sbjct: 3187 GRGGSEGCNIPQNIERLNGQGVCQIECGAQFSLALTKSGVVWTWGKGDYFRLGHGSDVHV 3246

Query: 923  KLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNSTAKSSPQKVD 1102
            + P+ V  L G +I  VA G  H LAV+ D   V+A+GD D+G+ G G +T    P  V 
Sbjct: 3247 RKPQVVEGLRGKKIVHVAVGALHCLAVT-DAGQVYAWGDNDHGQQGNGTTTVNRKPTLVQ 3305

Query: 1103 VLCGIGIKKVACGTQFSVALT 1165
             L G  I +VACG+  SVA T
Sbjct: 3306 GLEGQKITRVACGSSHSVAWT 3326



 Score =  158 bits (400), Expect = 3e-38
 Identities = 117/399 (29%), Positives = 187/399 (46%), Gaps = 34/399 (8%)
 Frame = +2

Query: 65   SLAVGLHLDQLL--CNPPV---PPHHQNCLPDPASWNPNEWAW-------LECFS----- 193
            ++ V  HLD+L   C PP+   P  H+  L +   W    W +       ++C       
Sbjct: 394  AVVVMAHLDRLATPCMPPLCSSPTSHKGSLQEVIGWGLIGWKYYANVIGPIQCEGLANLG 453

Query: 194  -TTIKAAEAL-----TNGAQFPESFSVPDLEPVPEDELVFLMDNSKWINGMDEQIMSWAT 355
             T I  AE        NG  + ++++   L P             + + G+  + +    
Sbjct: 454  VTQIACAEKRFLILSRNGRVYTQAYNSDTLAP-------------QLVQGLASRNIVKIA 500

Query: 356  SRPEDWH---LGGKCDVYLWGAGRHGQLA-------EAGRNVMVXXXXXXXXXXXXVICG 505
            +  +  H   L    +VY WG G  G+L        E  + +              + CG
Sbjct: 501  AHSDGHHYLALAATGEVYSWGCGDGGRLGHGDTVPLEEPKVISAFSGKQAGKHVVHIACG 560

Query: 506  QNCTFVIQANGTVLACGEGSYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGS-DGHS 682
               +  I A G +   G G+YGRLG G+S+D  +  +++ L+G  V  +  +CGS D  +
Sbjct: 561  STYSAAITAEGELYTWGRGNYGRLGHGSSEDEAIPMLVAGLKGLKVIDV--ACGSGDAQT 618

Query: 683  MALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGK 862
            +A+TE+G+V+SWGDGDYGKLG G SD  + P+ IE LQ  +VV++ CG + S  +T DG+
Sbjct: 619  LAVTENGQVWSWGDGDYGKLGRGGSDGCKTPKLIEKLQDLDVVKVRCGSQFSIALTKDGQ 678

Query: 863  LFTFGNGDYGRLGLGNTSNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDG 1042
            ++++G GD  RLG G   + + P+ +  L+G ++  VA G  H LA++ D S V ++G  
Sbjct: 679  VYSWGKGDNQRLGHGTEEHVRYPKLLEGLQGKKVIDVAAGSTHCLALTED-SEVHSWGSN 737

Query: 1043 DYGKLGLGNSTAKSSPQKVDVLCGIGIKKVACGTQFSVA 1159
            D  +        K  P  +  L    I  +ACG   S A
Sbjct: 738  DQCQHFDTLRVTKPEPAALPGLDTKHIVGIACGPAQSFA 776



 Score =  138 bits (347), Expect = 4e-32
 Identities = 95/273 (34%), Positives = 136/273 (49%), Gaps = 5/273 (1%)
 Frame = +2

Query: 674  GHSMALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTS 853
            G   A T   +VF WG  D  +LG     + + P   E L    VVQ++ G K    VT 
Sbjct: 2951 GLESAATIRTKVFVWGLNDKDQLGGLKGSKIKVPSFSETLSALNVVQVAGGSKSLFAVTV 3010

Query: 854  DGKLFTFGNGDYGRLGLGNTSNK-KLPERVTALEGYQIGQVA--CGLNHTLAVSADGSMV 1024
            +GK++  G    GRLGLG +S    +P ++TAL  Y + +VA   G  H  A++ DG  V
Sbjct: 3011 EGKVYACGEATNGRLGLGLSSGTVPIPRQITALSSYVVKKVAVHSGGRHATALTVDGK-V 3069

Query: 1025 WAFGDGDYGKLGLGNSTAKSSPQKVDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRL 1204
            +++G+GD GKLG  +      P+ ++ L    I+ +ACG+  S ALT  G +YT+G    
Sbjct: 3070 FSWGEGDDGKLGHFSRMNCDKPRLIEALKTKRIRDIACGSSHSAALTSSGELYTWGLGEY 3129

Query: 1205 IGLPEGRARNHNRPQQIPVLAGVVIEDVAVGAE--HTLALASTGDVYAWGSNSEGQLGLG 1378
              L  G      +P+ + VL G  +  VA G+    TLAL   G V++WG    G+LG G
Sbjct: 3130 GRLGHGDNTTQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFSWGDGDFGKLGRG 3189

Query: 1379 HTNHVREPTLVTVLQGKNVRQISAGRCHSAAWT 1477
             +     P  +  L G+ V QI  G   S A T
Sbjct: 3190 GSEGCNIPQNIERLNGQGVCQIECGAQFSLALT 3222



 Score = 68.6 bits (166), Expect = 4e-11
 Identities = 46/139 (33%), Positives = 73/139 (52%), Gaps = 8/139 (5%)
 Frame = +2

Query: 1088 PQKVDVLCGIGIKKVACGTQFSVALTKDGHVYT--FGQDRLIGLPEGRARNHNRPQQIPV 1261
            P + + L  +G+ ++AC  +  + L+++G VYT  +  D L             PQ +  
Sbjct: 443  PIQCEGLANLGVTQIACAEKRFLILSRNGRVYTQAYNSDTL------------APQLVQG 490

Query: 1262 LAGVVIEDVAVGAE--HTLALASTGDVYAWGSNSEGQLGLGHTNHVREPTLVTVLQ---- 1423
            LA   I  +A  ++  H LALA+TG+VY+WG    G+LG G T  + EP +++       
Sbjct: 491  LASRNIVKIAAHSDGHHYLALAATGEVYSWGCGDGGRLGHGDTVPLEEPKVISAFSGKQA 550

Query: 1424 GKNVRQISAGRCHSAAWTA 1480
            GK+V  I+ G  +SAA TA
Sbjct: 551  GKHVVHIACGSTYSAAITA 569


>ref|XP_865375.1| PREDICTED: similar to guanine nucleotide exchange factor p532 isoform
            2 [Canis familiaris].
          Length = 285

 Score =  547 bits (1409), Expect = e-155
 Identities = 272/285 (95%), Positives = 273/285 (95%)
 Frame = +2

Query: 2129 MQFKFLGILMGVAIRTKKPLDLHLAPLVWKQLCCVPXXXXXXXXXXXXYVQTLNSILHIE 2308
            MQFKFLGILMGVAIRTKKPLDLHLAPLVWKQLCCVP            YVQTLNSILHIE
Sbjct: 1    MQFKFLGILMGVAIRTKKPLDLHLAPLVWKQLCCVPLTLEDLEEVDLLYVQTLNSILHIE 60

Query: 2309 DSGITEESFHEMIPLDSFVGQSADGKMVPIIPGGNSIPLTFSNRKEYVERAIEYRLHEMD 2488
            DSGITEESFHEMIPLDSF+GQSADGKMVPIIPGGNSIPLTFSNRKEYVERAIEYRLHEMD
Sbjct: 61   DSGITEESFHEMIPLDSFIGQSADGKMVPIIPGGNSIPLTFSNRKEYVERAIEYRLHEMD 120

Query: 2489 RQVAAVREGMSWIVPVPLLSLLTAKQLEQMVCGMPEISVEVLKKVVRYREVDEQHQLVQW 2668
            RQVAAVREGMSWIVPVPLLSLLTAKQLEQMVCGMPEISVEVLKKVVRYREVDEQHQLVQW
Sbjct: 121  RQVAAVREGMSWIVPVPLLSLLTAKQLEQMVCGMPEISVEVLKKVVRYREVDEQHQLVQW 180

Query: 2669 FWHTLEEFSNEERVLFMRFVSGRSRLPANTADISQRFQIMKVDRPYDSLPTSQTCFFQLR 2848
            FWHTLEEFSNEERVLFMRFVSGRSRLPANTADISQRFQIMKVDRPYDSLPTSQTCFFQLR
Sbjct: 181  FWHTLEEFSNEERVLFMRFVSGRSRLPANTADISQRFQIMKVDRPYDSLPTSQTCFFQLR 240

Query: 2849 LPPYSSQLVMAERLRYAINNCRSIDMDNYMLSRNVDNAEGSDTDY 2983
            LPPYSSQLVMAERLRYAINNCRSIDMDNYMLSRNVDNAEGSDTDY
Sbjct: 241  LPPYSSQLVMAERLRYAINNCRSIDMDNYMLSRNVDNAEGSDTDY 285


>ref|XP_853300.1| PREDICTED: similar to guanine nucleotide exchange factor p532 [Canis
            familiaris].
          Length = 637

 Score =  244 bits (622), Expect = 5e-64
 Identities = 123/267 (46%), Positives = 177/267 (66%), Gaps = 2/267 (0%)
 Frame = +2

Query: 389  CDVYLWGAGRHGQLAEAGRNVMVXXXXXXXXXXXXVI-CGQNCTFVIQANGTVLACGEGS 565
            C+VY+WG+    QL E  +  ++             I  GQ CTFVI  +G+V ACG+GS
Sbjct: 372  CEVYVWGSNSSHQLVEGTQEKILQPKMALSFSDAQTIEAGQYCTFVISTDGSVRACGKGS 431

Query: 566  YGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSDGHSMALTESGEVFSWGDGDYGKLG 745
            YGRLG G+S++   L  ++      + ++ +S GSDGH++A T  GEVFSWGDGDYGKLG
Sbjct: 432  YGRLGLGDSNNQSTLKKLTFEPHRSIKKVSSSKGSDGHTLAFTTEGEVFSWGDGDYGKLG 491

Query: 746  HGNSDRQRRPRQIEA-LQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLGLGNTSNK 922
            HGNS  Q+ P+ I+  LQG+ VV +S G++HSA VT DG+L+T+G GD+GRLG G+++++
Sbjct: 492  HGNSSTQKYPKLIQGPLQGKVVVCVSAGYRHSAAVTEDGELYTWGEGDFGRLGHGDSNSR 551

Query: 923  KLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNSTAKSSPQKVD 1102
             +P  V  +    +G+V+CG +HT+A+S DG  VW+FG GD GKLG G++     P+ V+
Sbjct: 552  NIPTLVKDIS--NVGEVSCGSSHTIALSKDGRTVWSFGGGDNGKLGHGDTNRVYKPKVVE 609

Query: 1103 VLCGIGIKKVACGTQFSVALTKDGHVY 1183
             L G+ I+KV  G+Q S+ALT  G V+
Sbjct: 610  ALQGMFIRKVCAGSQSSLALTSTGQVF 636



 Score =  144 bits (362), Expect = 8e-34
 Identities = 91/274 (33%), Positives = 154/274 (56%), Gaps = 5/274 (1%)
 Frame = +2

Query: 674  GHSMALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTS 853
            G +  ++E+ EV+ WG     +L  G  ++  +P+   AL   +   +  G   + V+++
Sbjct: 363  GDAPIVSETCEVYVWGSNSSHQLVEGTQEKILQPKM--ALSFSDAQTIEAGQYCTFVIST 420

Query: 854  DGKLFTFGNGDYGRLGLGNTSNKKLPERVTALEGYQIGQVACGL---NHTLAVSADGSMV 1024
            DG +   G G YGRLGLG+++N+   +++T      I +V+       HTLA + +G  V
Sbjct: 421  DGSVRACGKGSYGRLGLGDSNNQSTLKKLTFEPHRSIKKVSSSKGSDGHTLAFTTEGE-V 479

Query: 1025 WAFGDGDYGKLGLGNSTAKSSPQKVD-VLCGIGIKKVACGTQFSVALTKDGHVYTFGQDR 1201
            +++GDGDYGKLG GNS+ +  P+ +   L G  +  V+ G + S A+T+DG +YT+G+  
Sbjct: 480  FSWGDGDYGKLGHGNSSTQKYPKLIQGPLQGKVVVCVSAGYRHSAAVTEDGELYTWGEGD 539

Query: 1202 LIGLPEGRARNHNRPQQIPVLAGVVIEDVAVGAEHTLALASTG-DVYAWGSNSEGQLGLG 1378
               L  G + + N P  +  ++ V   +V+ G+ HT+AL+  G  V+++G    G+LG G
Sbjct: 540  FGRLGHGDSNSRNIPTLVKDISNV--GEVSCGSSHTIALSKDGRTVWSFGGGDNGKLGHG 597

Query: 1379 HTNHVREPTLVTVLQGKNVRQISAGRCHSAAWTA 1480
             TN V +P +V  LQG  +R++ AG   S A T+
Sbjct: 598  DTNRVYKPKVVEALQGMFIRKVCAGSQSSLALTS 631



 Score =  132 bits (331), Expect = 3e-30
 Identities = 77/225 (34%), Positives = 135/225 (60%), Gaps = 5/225 (2%)
 Frame = +2

Query: 680  SMALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQI--EALQGEEVVQMSCGFK-HSAVVT 850
            +  ++  G V + G G YG+LG G+S+ Q   +++  E  +  + V  S G   H+   T
Sbjct: 415  TFVISTDGSVRACGKGSYGRLGLGDSNNQSTLKKLTFEPHRSIKKVSSSKGSDGHTLAFT 474

Query: 851  SDGKLFTFGNGDYGRLGLGNTSNKKLPERVTA-LEGYQIGQVACGLNHTLAVSADGSMVW 1027
            ++G++F++G+GDYG+LG GN+S +K P+ +   L+G  +  V+ G  H+ AV+ DG + +
Sbjct: 475  TEGEVFSWGDGDYGKLGHGNSSTQKYPKLIQGPLQGKVVVCVSAGYRHSAAVTEDGEL-Y 533

Query: 1028 AFGDGDYGKLGLGNSTAKSSPQKVDVLCGIGIKKVACGTQFSVALTKDGH-VYTFGQDRL 1204
             +G+GD+G+LG G+S +++ P  V  +  +G  +V+CG+  ++AL+KDG  V++FG    
Sbjct: 534  TWGEGDFGRLGHGDSNSRNIPTLVKDISNVG--EVSCGSSHTIALSKDGRTVWSFGGGDN 591

Query: 1205 IGLPEGRARNHNRPQQIPVLAGVVIEDVAVGAEHTLALASTGDVY 1339
              L  G      +P+ +  L G+ I  V  G++ +LAL STG V+
Sbjct: 592  GKLGHGDTNRVYKPKVVEALQGMFIRKVCAGSQSSLALTSTGQVF 636


>ref|XP_539635.2| PREDICTED: similar to HECT domain containing 3 isoform 1 [Canis
            familiaris].
          Length = 861

 Score =  189 bits (481), Expect = 1e-47
 Identities = 122/349 (34%), Positives = 182/349 (52%), Gaps = 9/349 (2%)
 Frame = +2

Query: 1910 DLRLPSRA---WKVKLVGEGADDAGGVFDDTITEMCQELETGIVDLLIPSP------NAT 2062
            D R P R    W+ K + EG  D GG F D++ +M +EL     D  +P P      N  
Sbjct: 517  DYRWPMRYDQWWECKFIAEGIIDQGGGFRDSLADMSEELCPSSADTPVPLPFFVRTANQG 576

Query: 2063 AEVGYNRDRFLFNPSACLDEHLMQFKFLGILMGVAIRTKKPLDLHLAPLVWKQLCCVPXX 2242
               G  RD ++ NPS C D    +++++G LMG A+R K+ L L L   VWKQL      
Sbjct: 577  NGTGEARDMYVPNPS-CRD--FAKYEWIGQLMGAALRGKEFLVLALPGFVWKQLSGEEVS 633

Query: 2243 XXXXXXXXXXYVQTLNSILHIEDSGITEESFHEMIPLDSFVGQSADGKMVPIIPGGNSIP 2422
                       +  L  ++   D    E  F + +   +F    +D ++V +IPGG  I 
Sbjct: 634  WSKDFPAVDSVLVKLLEVMEGMDKETFEFKFGKEL---TFTTVLSDQQVVELIPGGAGIV 690

Query: 2423 LTFSNRKEYVERAIEYRLHEMDRQVAAVREGMSWIVPVPLLSLLTAKQLEQMVCGMPEIS 2602
            + + +R  +++   + RL E   QVAA++ G+  +VP  +L LLT ++LE+ VCG PE++
Sbjct: 691  VGYEDRSRFIQLVQKTRLEESKEQVAAMQAGLLKVVPQAVLDLLTWQELEKKVCGDPEVT 750

Query: 2603 VEVLKKVVRYREVDEQHQLVQWFWHTLEEFSNEERVLFMRFVSGRSRLPANTADISQRFQ 2782
            V+ L+K+ R+ + +     VQ+FW  L  F+NE+R  F+RFV+GRSRLPA       +  
Sbjct: 751  VDALRKLTRFEDFEPSDTRVQYFWEALNNFTNEDRSRFLRFVTGRSRLPARIYIYPDKLG 810

Query: 2783 IMKVDRPYDSLPTSQTCFFQLRLPPYSSQLVMAERLRYAINNCRSIDMD 2929
                    D+LP S TC   L LP Y+S  +  E+LRYA  NC +ID D
Sbjct: 811  Y----ETTDALPESSTCSSTLFLPHYASAKLCEEKLRYAAYNCVAIDTD 855


>ref|XP_535653.2| PREDICTED: similar to HECT domain and RCC1-like domain protein 3
            [Canis familiaris].
          Length = 1051

 Score =  174 bits (440), Expect = 7e-43
 Identities = 113/326 (34%), Positives = 179/326 (54%), Gaps = 7/326 (2%)
 Frame = +2

Query: 494  VICGQNCTFVIQANGTVLACGEGSYGRLG---QGNSDDLHVLTVISALQGFVVTQLVTSC 664
            V CG N +  +  +G V  CG  + G+LG   +GN  +      I AL    +  +  +C
Sbjct: 39   VACGGNHSVFLLEDGEVYTCGLNTKGQLGHEREGNKPEQ-----IGALADQHIVHV--AC 91

Query: 665  GSDGHSMALTESGEVFSWGDGDYGKLG-HGNSDRQRRPRQIEALQGEEVVQMSCGFKHSA 841
            G + HS+AL++ G++FSWG G  G+LG     D    PR I+ L  + ++Q+SCG  H  
Sbjct: 92   G-ESHSLALSDRGQLFSWGAGSDGQLGLMTTEDSVAVPRLIQKLNQQTILQVSCGNWHCL 150

Query: 842  VVTSDGKLFTFGNGDYGRLGLGNT-SNKKLPERVTALEGYQIGQVACGLNHTLAVSADGS 1018
             + +DG+ FT+G   +G+LGLG    ++  P+RV +LEG  + QVA G  H+ A+S  G+
Sbjct: 151  ALAADGQFFTWGKNSHGQLGLGKEYPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLSGA 210

Query: 1019 MVWAFGDGDYGKLGLGNSTA-KSSPQKVDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQ 1195
             V+ +G  + G+LGL +    + SP  V +L    +  ++CG + +  LTK G V+TFG 
Sbjct: 211  -VFGWGMNNAGQLGLSDEEGNRESPCHVKLLRTQKVVYISCGEEHTAVLTKSGGVFTFGA 269

Query: 1196 DRLIGLPEGRARNHNRPQQIPVLAGVVIEDVAVGAEHTLALA-STGDVYAWGSNSEGQLG 1372
                 L      +   P+++  L G  +  +A G +HTLA   S+G +YA+G  ++GQLG
Sbjct: 270  GSCGQLGHDSMNDEVNPRRVLELMGSEVTQIACGRQHTLAFVPSSGLIYAFGCGAKGQLG 329

Query: 1373 LGHTNHVREPTLVTVLQGKNVRQISA 1450
             GHT +V+ P+ V      +  Q+SA
Sbjct: 330  TGHTCNVKCPSPVKGYWAAHSGQLSA 355



 Score =  157 bits (398), Expect = 5e-38
 Identities = 114/329 (34%), Positives = 170/329 (51%), Gaps = 7/329 (2%)
 Frame = +2

Query: 566  YGRLGQ-GNSDDLHVLTVISALQGFVVTQLV--TSCGSDGHSMALTESGEVFSWGDGDYG 736
            Y  LGQ G S +L  +     + GF+  + V   +CG + HS+ L E GEV++ G    G
Sbjct: 6    YWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGN-HSVFLLEDGEVYTCGLNTKG 64

Query: 737  KLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLGLGNTS 916
            +LGH       +P QI AL  + +V ++CG  HS  ++  G+LF++G G  G+LGL  T 
Sbjct: 65   QLGHEREGN--KPEQIGALADQHIVHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTE 122

Query: 917  NK-KLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNS-TAKSSP 1090
            +   +P  +  L    I QV+CG  H LA++ADG   + +G   +G+LGLG    +++SP
Sbjct: 123  DSVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQF-FTWGKNSHGQLGLGKEYPSQASP 181

Query: 1091 QKVDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRL--IGLPEGRARNHNRPQQIPVL 1264
            Q+V  L GI + +VA G   S AL+  G V+ +G +    +GL +    N   P  + +L
Sbjct: 182  QRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEEG-NRESPCHVKLL 240

Query: 1265 AGVVIEDVAVGAEHTLALASTGDVYAWGSNSEGQLGLGHTNHVREPTLVTVLQGKNVRQI 1444
                +  ++ G EHT  L  +G V+ +G+ S GQLG    N    P  V  L G  V QI
Sbjct: 241  RTQKVVYISCGEEHTAVLTKSGGVFTFGAGSCGQLGHDSMNDEVNPRRVLELMGSEVTQI 300

Query: 1445 SAGRCHSAAWTAPPVPPRAPGVSVPLQLG 1531
            + GR H+ A+        A G     QLG
Sbjct: 301  ACGRQHTLAFVPSSGLIYAFGCGAKGQLG 329



 Score =  131 bits (329), Expect = 5e-30
 Identities = 84/263 (31%), Positives = 128/263 (48%), Gaps = 6/263 (2%)
 Frame = +2

Query: 329  DEQIMSWATSRPEDWHLGGKCDVYLWGAGRHGQLA----EAGRNVMVXXXXXXXXXXXXV 496
            D+ I+  A        L  +  ++ WGAG  GQL     E    V              V
Sbjct: 83   DQHIVHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTEDSVAVPRLIQKLNQQTILQV 142

Query: 497  ICGQNCTFVIQANGTVLACGEGSYGRLGQGNSDDLHVLTV-ISALQGFVVTQLVTSCGSD 673
             CG      + A+G     G+ S+G+LG G           + +L+G  + Q+       
Sbjct: 143  SCGNWHCLALAADGQFFTWGKNSHGQLGLGKEYPSQASPQRVRSLEGIPLAQVAAG---G 199

Query: 674  GHSMALTESGEVFSWGDGDYGKLGHGNSDRQRR-PRQIEALQGEEVVQMSCGFKHSAVVT 850
             HS AL+ SG VF WG  + G+LG  + +  R  P  ++ L+ ++VV +SCG +H+AV+T
Sbjct: 200  AHSFALSLSGAVFGWGMNNAGQLGLSDEEGNRESPCHVKLLRTQKVVYISCGEEHTAVLT 259

Query: 851  SDGKLFTFGNGDYGRLGLGNTSNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWA 1030
              G +FTFG G  G+LG  + +++  P RV  L G ++ Q+ACG  HTLA      +++A
Sbjct: 260  KSGGVFTFGAGSCGQLGHDSMNDEVNPRRVLELMGSEVTQIACGRQHTLAFVPSSGLIYA 319

Query: 1031 FGDGDYGKLGLGNSTAKSSPQKV 1099
            FG G  G+LG G++     P  V
Sbjct: 320  FGCGAKGQLGTGHTCNVKCPSPV 342



 Score = 92.4 bits (228), Expect = 3e-18
 Identities = 87/337 (25%), Positives = 144/337 (42%), Gaps = 4/337 (1%)
 Frame = +2

Query: 1910 DLRLPSRAWKVKLVGEGADDAGGVFDDTITEMCQELETGIVDLLIPSPNATAEVGYNRDR 2089
            DL+ P    KV   GE A DAGGV  +    + +EL   I  +            Y    
Sbjct: 727  DLKKPL---KVIFDGEEAVDAGGVTKEFFLLLLKELLNPIYGMF---------TYYQDSN 774

Query: 2090 FLFNPSACLDEHLMQFKFLGILMGVAIRTKKPLDLHLAPLVWKQLCCVPXXXXXXXXXXX 2269
             L+    C  EH   F  +GI  G+AI     +DLH    ++K+L  V            
Sbjct: 775  LLWFSDTCFVEHNW-FHLIGITCGLAIYNSTVVDLHFPLALYKKLLNVKPGLEDLKELSP 833

Query: 2270 XYVQTLNSILHIEDSGITEESFHEMIPLDSFVGQSADG--KMVPIIPGGNSIPLTFSNRK 2443
               ++L  +L      I EE+F     L+  + + + G  +   +IPGG+ + +   NR+
Sbjct: 834  TEGRSLQELLDYPGEDI-EETFC----LNFTICRESYGVIEQKKLIPGGDKVTVCKDNRQ 888

Query: 2444 EYVERAIEYRLH-EMDRQVAAVREGMSWIVPVPLLSLLTAKQLEQMVCGMPEISVEVLKK 2620
            E+V+  + Y     +     A   G   +    +L L    +L  M+ G    + + L++
Sbjct: 889  EFVDAYVNYVFQISVHEWYTAFSSGFLKVCGGKVLELFQPSELRAMMVGNSNYNWQELEE 948

Query: 2621 VVRYR-EVDEQHQLVQWFWHTLEEFSNEERVLFMRFVSGRSRLPANTADISQRFQIMKVD 2797
               Y+ +    H  V+ FW T  EF  E++  F+ F++G  R+P      S +  I    
Sbjct: 949  TAIYKGDYSATHPTVKLFWETFHEFPLEKKKKFLLFLTGSDRIPI-YGMASLQIVIQSTA 1007

Query: 2798 RPYDSLPTSQTCFFQLRLPPYSSQLVMAERLRYAINN 2908
               + LP + TC+  L LP YSS+ +++  L  A++N
Sbjct: 1008 SGEEYLPVAHTCYNLLDLPKYSSKEILSAGLTQALDN 1044


>ref|XP_860006.1| PREDICTED: similar to hect domain and RLD 4 isoform a isoform 9
            [Canis familiaris].
          Length = 1054

 Score =  162 bits (410), Expect = 2e-39
 Identities = 99/307 (32%), Positives = 161/307 (52%), Gaps = 3/307 (0%)
 Frame = +2

Query: 500  CGQNCTFVIQANGTVLACGEGSYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSDGH 679
            CG   T  +  +GTV  CG    G+LG   S       V    Q  V      SCG + H
Sbjct: 41   CGLRHTVFVLDDGTVYTCGCNDLGQLGHEKSRKKPEQVVALDAQNIV----AVSCG-EAH 95

Query: 680  SMALTESGEVFSWGDGDYGKLG-HGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSD 856
            ++AL + G+V++WG    G+LG  G+ +  R PR I++L   ++VQ++CG+ HS  ++ +
Sbjct: 96   TLALNDKGQVYAWGLDSDGQLGLLGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKE 155

Query: 857  GKLFTFGNGDYGRLGLGNTSNKKL-PERVTALEGYQIGQVACGLNHTLAVSADGSMVWAF 1033
            G+ F +G   YG+LGLG    K+  P+ + +L G    QVA G  H+  ++  G+ ++ +
Sbjct: 156  GEFFCWGQNKYGQLGLGIDCKKQASPQLIKSLLGIPFMQVAAGGAHSFVLTLSGA-IFGW 214

Query: 1034 GDGDYGKLGLGNSTAKSSPQKVDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGL 1213
            G   +G+LGL +   +  P  +  L    I  + CG   + ALTK+G V+TFG      L
Sbjct: 215  GRNKFGQLGLNDENDRYVPNLLKSLRTQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQL 274

Query: 1214 PEGRARNHNRPQQIPVLAGVVIEDVAVGAEHTLA-LASTGDVYAWGSNSEGQLGLGHTNH 1390
                  +   P+++  L G ++  +A G +HT A + S+G +Y++G    GQLG G T++
Sbjct: 275  GHNSTSHEINPRKVFELMGSIVTQIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSN 334

Query: 1391 VREPTLV 1411
             + P  V
Sbjct: 335  RKSPFTV 341



 Score =  161 bits (408), Expect = 4e-39
 Identities = 104/314 (33%), Positives = 164/314 (52%), Gaps = 3/314 (0%)
 Frame = +2

Query: 542  VLACGEGSYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSD-GHSMALTESGEVFSW 718
            +L  G  S+G+LG G  D+  VL    +   F + + V   G    H++ + + G V++ 
Sbjct: 1    MLCWGNASFGQLGLGGIDEEIVLEPRKS--DFFINKKVRDVGCGLRHTVFVLDDGTVYTC 58

Query: 719  GDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRL 898
            G  D G+LGH  S  +++P Q+ AL  + +V +SCG  H+  +   G+++ +G    G+L
Sbjct: 59   GCNDLGQLGHEKS--RKKPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQL 116

Query: 899  GL-GNTSNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNST 1075
            GL G+    ++P  + +L   QI QVACG  H+LA+S +G   + +G   YG+LGLG   
Sbjct: 117  GLLGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKEGEF-FCWGQNKYGQLGLGIDC 175

Query: 1076 AK-SSPQKVDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGLPEGRARNHNRPQQ 1252
             K +SPQ +  L GI   +VA G   S  LT  G ++ +G+++   L      +   P  
Sbjct: 176  KKQASPQLIKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNL 235

Query: 1253 IPVLAGVVIEDVAVGAEHTLALASTGDVYAWGSNSEGQLGLGHTNHVREPTLVTVLQGKN 1432
            +  L    I  +  G +HT AL   G V+ +G+   GQLG   T+H   P  V  L G  
Sbjct: 236  LKSLRTQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSI 295

Query: 1433 VRQISAGRCHSAAW 1474
            V QI+ GR H++A+
Sbjct: 296  VTQIACGRQHTSAF 309



 Score =  148 bits (374), Expect = 3e-35
 Identities = 91/258 (35%), Positives = 138/258 (53%), Gaps = 4/258 (1%)
 Frame = +2

Query: 716  WGDGDYGKLGHGNSDRQ--RRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDY 889
            WG+  +G+LG G  D +    PR+ +    ++V  + CG +H+  V  DG ++T G  D 
Sbjct: 4    WGNASFGQLGLGGIDEEIVLEPRKSDFFINKKVRDVGCGLRHTVFVLDDGTVYTCGCNDL 63

Query: 890  GRLGLGNTSNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGL-G 1066
            G+LG  +  ++K PE+V AL+   I  V+CG  HTLA++ D   V+A+G    G+LGL G
Sbjct: 64   GQLG--HEKSRKKPEQVVALDAQNIVAVSCGEAHTLALN-DKGQVYAWGLDSDGQLGLLG 120

Query: 1067 NSTAKSSPQKVDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGLPEG-RARNHNR 1243
            +      P+ +  L  I I +VACG   S+AL+K+G  + +GQ++   L  G   +    
Sbjct: 121  SEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKEGEFFCWGQNKYGQLGLGIDCKKQAS 180

Query: 1244 PQQIPVLAGVVIEDVAVGAEHTLALASTGDVYAWGSNSEGQLGLGHTNHVREPTLVTVLQ 1423
            PQ I  L G+    VA G  H+  L  +G ++ WG N  GQLGL   N    P L+  L+
Sbjct: 181  PQLIKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLR 240

Query: 1424 GKNVRQISAGRCHSAAWT 1477
             + +  I  G  H+AA T
Sbjct: 241  TQKIVYICCGEDHTAALT 258



 Score =  128 bits (322), Expect = 3e-29
 Identities = 76/243 (31%), Positives = 117/243 (48%), Gaps = 5/243 (2%)
 Frame = +2

Query: 377  LGGKCDVYLWGAGRHGQLAEAGRNVMVXXXXXXXXXXXX----VICGQNCTFVIQANGTV 544
            L  K  VY WG    GQL   G    +                V CG   +  +   G  
Sbjct: 99   LNDKGQVYAWGLDSDGQLGLLGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKEGEF 158

Query: 545  LACGEGSYGRLGQGNSDDLHVLT-VISALQGFVVTQLVTSCGSDGHSMALTESGEVFSWG 721
               G+  YG+LG G          +I +L G    Q+        HS  LT SG +F WG
Sbjct: 159  FCWGQNKYGQLGLGIDCKKQASPQLIKSLLGIPFMQVAAG---GAHSFVLTLSGAIFGWG 215

Query: 722  DGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLG 901
               +G+LG  + + +  P  +++L+ +++V + CG  H+A +T +G +FTFG G YG+LG
Sbjct: 216  RNKFGQLGLNDENDRYVPNLLKSLRTQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLG 275

Query: 902  LGNTSNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNSTAK 1081
              +TS++  P +V  L G  + Q+ACG  HT A       +++FG G  G+LG G+++ +
Sbjct: 276  HNSTSHEINPRKVFELMGSIVTQIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSNR 335

Query: 1082 SSP 1090
             SP
Sbjct: 336  KSP 338



 Score =  109 bits (273), Expect = 2e-23
 Identities = 65/209 (31%), Positives = 110/209 (52%), Gaps = 8/209 (3%)
 Frame = +2

Query: 329 DEQIMSWATSRPEDWHLGGKCDVYLWGAGRHGQLA-------EAGRNVMVXXXXXXXXXX 487
           D QI+  A        L  + + + WG  ++GQL        +A   ++           
Sbjct: 136 DIQIVQVACGYYHSLALSKEGEFFCWGQNKYGQLGLGIDCKKQASPQLI---KSLLGIPF 192

Query: 488 XXVICGQNCTFVIQANGTVLACGEGSYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCG 667
             V  G   +FV+  +G +   G   +G+LG  + +D +V  ++ +L+     ++V  C 
Sbjct: 193 MQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLR---TQKIVYICC 249

Query: 668 SDGHSMALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKH-SAV 844
            + H+ ALT+ G VF++G G YG+LGH ++  +  PR++  L G  V Q++CG +H SA 
Sbjct: 250 GEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTQIACGRQHTSAF 309

Query: 845 VTSDGKLFTFGNGDYGRLGLGNTSNKKLP 931
           V S G++++FG G  G+LG G+TSN+K P
Sbjct: 310 VPSSGRIYSFGLGGNGQLGTGSTSNRKSP 338



 Score = 74.3 bits (181), Expect = 7e-13
 Identities = 78/329 (23%), Positives = 139/329 (42%), Gaps = 5/329 (1%)
 Frame = +2

Query: 1937 KVKLVGEGADDAGGVFDDTITEMCQELETGIVDLLIPSPNATAEVGYNRDRFL-FNPSAC 2113
            KV  VGE A DAGGV  +    + +EL           P       Y   R + F+    
Sbjct: 736  KVIFVGEDAVDAGGVRKEFFLLIMRELL---------DPKYGMFRYYEDSRLIWFSDKTF 786

Query: 2114 LDEHLMQFKFLGILMGVAIRTKKPLDLHLAPLVWKQLCCVPXXXXXXXXXXXXYVQTLNS 2293
             D  L  F  +G++ G+AI     +DLH    ++K+L                  +++  
Sbjct: 787  EDSDL--FHLIGVICGLAIYNFTIVDLHFPLALYKKLLKKKPSLDDLKELVPDVGRSMQQ 844

Query: 2294 ILHIEDSGITEESF--HEMIPLDSFVGQSADGKMVPIIPGGNSIPLTFSNRKEYVERAIE 2467
            +L   +  + EE+F  +  I +++F       ++  ++  G    +   NR+E+V+  ++
Sbjct: 845  LLDYPEDDV-EETFCLNFTITVENFGAT----EVKELVLNGADTAVNKQNRQEFVDAYVD 899

Query: 2468 YRLHEMDRQVA-AVREGMSWIVPVPLLSLLTAKQLEQMVCGMPEISVEVLKKVVRYR-EV 2641
            Y  ++    +  A   G   +    +L L    +L+ MV G      + L+K   Y+ E 
Sbjct: 900  YIFNKSVASLFDAFHAGFHKVCGGKVLQLFQPNELQAMVIGNTNYDWKELEKNTEYKGEY 959

Query: 2642 DEQHQLVQWFWHTLEEFSNEERVLFMRFVSGRSRLPANTADISQRFQIMKVDRPYDSLPT 2821
              +H  ++ FW    E   E++  F+ F++G  R+P      S +  I       + LP 
Sbjct: 960  WAEHPTIKIFWEVFHELPLEKKKQFLLFLTGSDRIPI-LGMKSLKLVIQSTGGGEEYLPV 1018

Query: 2822 SQTCFFQLRLPPYSSQLVMAERLRYAINN 2908
            S TCF  L LP Y+ +  +  +L  AI++
Sbjct: 1019 SHTCFNLLDLPKYTEKETLRSKLIQAIDH 1047


>ref|XP_536367.2| PREDICTED: similar to hect domain and RLD 4 isoform b isoform 1
            [Canis familiaris].
          Length = 1049

 Score =  160 bits (406), Expect = 6e-39
 Identities = 105/314 (33%), Positives = 164/314 (52%), Gaps = 3/314 (0%)
 Frame = +2

Query: 542  VLACGEGSYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSD-GHSMALTESGEVFSW 718
            +L  G  S+G+LG G  D+  VL    +   F + + V   G    H++ + + G V++ 
Sbjct: 1    MLCWGNASFGQLGLGGIDEEIVLEPRKS--DFFINKKVRDVGCGLRHTVFVLDDGTVYTC 58

Query: 719  GDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRL 898
            G  D G+LGH  S  +++P Q+ AL  + +V +SCG  H+  +   G+++ +G    G+L
Sbjct: 59   GCNDLGQLGHEKS--RKKPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQL 116

Query: 899  GL-GNTSNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNST 1075
            GL G+    ++P  + +L   QI QVACG  H+LA+S   S V+ +G   YG+LGLG   
Sbjct: 117  GLLGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSK-ASEVFCWGQNKYGQLGLGIDC 175

Query: 1076 AK-SSPQKVDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGLPEGRARNHNRPQQ 1252
             K +SPQ +  L GI   +VA G   S  LT  G ++ +G+++   L      +   P  
Sbjct: 176  KKQASPQLIKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNL 235

Query: 1253 IPVLAGVVIEDVAVGAEHTLALASTGDVYAWGSNSEGQLGLGHTNHVREPTLVTVLQGKN 1432
            +  L    I  +  G +HT AL   G V+ +G+   GQLG   T+H   P  V  L G  
Sbjct: 236  LKSLRTQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSI 295

Query: 1433 VRQISAGRCHSAAW 1474
            V QI+ GR H++A+
Sbjct: 296  VTQIACGRQHTSAF 309



 Score =  159 bits (401), Expect = 2e-38
 Identities = 98/307 (31%), Positives = 160/307 (52%), Gaps = 3/307 (0%)
 Frame = +2

Query: 500  CGQNCTFVIQANGTVLACGEGSYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSDGH 679
            CG   T  +  +GTV  CG    G+LG   S       V    Q  V      SCG + H
Sbjct: 41   CGLRHTVFVLDDGTVYTCGCNDLGQLGHEKSRKKPEQVVALDAQNIV----AVSCG-EAH 95

Query: 680  SMALTESGEVFSWGDGDYGKLG-HGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSD 856
            ++AL + G+V++WG    G+LG  G+ +  R PR I++L   ++VQ++CG+ HS  ++  
Sbjct: 96   TLALNDKGQVYAWGLDSDGQLGLLGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKA 155

Query: 857  GKLFTFGNGDYGRLGLGNTSNKKL-PERVTALEGYQIGQVACGLNHTLAVSADGSMVWAF 1033
             ++F +G   YG+LGLG    K+  P+ + +L G    QVA G  H+  ++  G+ ++ +
Sbjct: 156  SEVFCWGQNKYGQLGLGIDCKKQASPQLIKSLLGIPFMQVAAGGAHSFVLTLSGA-IFGW 214

Query: 1034 GDGDYGKLGLGNSTAKSSPQKVDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGL 1213
            G   +G+LGL +   +  P  +  L    I  + CG   + ALTK+G V+TFG      L
Sbjct: 215  GRNKFGQLGLNDENDRYVPNLLKSLRTQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQL 274

Query: 1214 PEGRARNHNRPQQIPVLAGVVIEDVAVGAEHTLA-LASTGDVYAWGSNSEGQLGLGHTNH 1390
                  +   P+++  L G ++  +A G +HT A + S+G +Y++G    GQLG G T++
Sbjct: 275  GHNSTSHEINPRKVFELMGSIVTQIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSN 334

Query: 1391 VREPTLV 1411
             + P  V
Sbjct: 335  RKSPFTV 341



 Score =  146 bits (369), Expect = 1e-34
 Identities = 91/258 (35%), Positives = 137/258 (53%), Gaps = 4/258 (1%)
 Frame = +2

Query: 716  WGDGDYGKLGHGNSDRQ--RRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDY 889
            WG+  +G+LG G  D +    PR+ +    ++V  + CG +H+  V  DG ++T G  D 
Sbjct: 4    WGNASFGQLGLGGIDEEIVLEPRKSDFFINKKVRDVGCGLRHTVFVLDDGTVYTCGCNDL 63

Query: 890  GRLGLGNTSNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGL-G 1066
            G+LG  +  ++K PE+V AL+   I  V+CG  HTLA++ D   V+A+G    G+LGL G
Sbjct: 64   GQLG--HEKSRKKPEQVVALDAQNIVAVSCGEAHTLALN-DKGQVYAWGLDSDGQLGLLG 120

Query: 1067 NSTAKSSPQKVDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGLPEG-RARNHNR 1243
            +      P+ +  L  I I +VACG   S+AL+K   V+ +GQ++   L  G   +    
Sbjct: 121  SEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGIDCKKQAS 180

Query: 1244 PQQIPVLAGVVIEDVAVGAEHTLALASTGDVYAWGSNSEGQLGLGHTNHVREPTLVTVLQ 1423
            PQ I  L G+    VA G  H+  L  +G ++ WG N  GQLGL   N    P L+  L+
Sbjct: 181  PQLIKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLR 240

Query: 1424 GKNVRQISAGRCHSAAWT 1477
             + +  I  G  H+AA T
Sbjct: 241  TQKIVYICCGEDHTAALT 258



 Score =  127 bits (319), Expect = 7e-29
 Identities = 76/243 (31%), Positives = 117/243 (48%), Gaps = 5/243 (2%)
 Frame = +2

Query: 377  LGGKCDVYLWGAGRHGQLAEAGRNVMVXXXXXXXXXXXX----VICGQNCTFVIQANGTV 544
            L  K  VY WG    GQL   G    +                V CG   +  +     V
Sbjct: 99   LNDKGQVYAWGLDSDGQLGLLGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEV 158

Query: 545  LACGEGSYGRLGQGNSDDLHVLT-VISALQGFVVTQLVTSCGSDGHSMALTESGEVFSWG 721
               G+  YG+LG G          +I +L G    Q+        HS  LT SG +F WG
Sbjct: 159  FCWGQNKYGQLGLGIDCKKQASPQLIKSLLGIPFMQVAAG---GAHSFVLTLSGAIFGWG 215

Query: 722  DGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLG 901
               +G+LG  + + +  P  +++L+ +++V + CG  H+A +T +G +FTFG G YG+LG
Sbjct: 216  RNKFGQLGLNDENDRYVPNLLKSLRTQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLG 275

Query: 902  LGNTSNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNSTAK 1081
              +TS++  P +V  L G  + Q+ACG  HT A       +++FG G  G+LG G+++ +
Sbjct: 276  HNSTSHEINPRKVFELMGSIVTQIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSNR 335

Query: 1082 SSP 1090
             SP
Sbjct: 336  KSP 338



 Score =  111 bits (278), Expect = 4e-24
 Identities = 66/209 (31%), Positives = 110/209 (52%), Gaps = 8/209 (3%)
 Frame = +2

Query: 329 DEQIMSWATSRPEDWHLGGKCDVYLWGAGRHGQLA-------EAGRNVMVXXXXXXXXXX 487
           D QI+  A        L    +V+ WG  ++GQL        +A   ++           
Sbjct: 136 DIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGIDCKKQASPQLI---KSLLGIPF 192

Query: 488 XXVICGQNCTFVIQANGTVLACGEGSYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCG 667
             V  G   +FV+  +G +   G   +G+LG  + +D +V  ++ +L+     ++V  C 
Sbjct: 193 MQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLR---TQKIVYICC 249

Query: 668 SDGHSMALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKH-SAV 844
            + H+ ALT+ G VF++G G YG+LGH ++  +  PR++  L G  V Q++CG +H SA 
Sbjct: 250 GEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTQIACGRQHTSAF 309

Query: 845 VTSDGKLFTFGNGDYGRLGLGNTSNKKLP 931
           V S G++++FG G  G+LG G+TSN+K P
Sbjct: 310 VPSSGRIYSFGLGGNGQLGTGSTSNRKSP 338



 Score = 74.3 bits (181), Expect = 7e-13
 Identities = 78/329 (23%), Positives = 139/329 (42%), Gaps = 5/329 (1%)
 Frame = +2

Query: 1937 KVKLVGEGADDAGGVFDDTITEMCQELETGIVDLLIPSPNATAEVGYNRDRFL-FNPSAC 2113
            KV  VGE A DAGGV  +    + +EL           P       Y   R + F+    
Sbjct: 731  KVIFVGEDAVDAGGVRKEFFLLIMRELL---------DPKYGMFRYYEDSRLIWFSDKTF 781

Query: 2114 LDEHLMQFKFLGILMGVAIRTKKPLDLHLAPLVWKQLCCVPXXXXXXXXXXXXYVQTLNS 2293
             D  L  F  +G++ G+AI     +DLH    ++K+L                  +++  
Sbjct: 782  EDSDL--FHLIGVICGLAIYNFTIVDLHFPLALYKKLLKKKPSLDDLKELVPDVGRSMQQ 839

Query: 2294 ILHIEDSGITEESF--HEMIPLDSFVGQSADGKMVPIIPGGNSIPLTFSNRKEYVERAIE 2467
            +L   +  + EE+F  +  I +++F       ++  ++  G    +   NR+E+V+  ++
Sbjct: 840  LLDYPEDDV-EETFCLNFTITVENFGAT----EVKELVLNGADTAVNKQNRQEFVDAYVD 894

Query: 2468 YRLHEMDRQVA-AVREGMSWIVPVPLLSLLTAKQLEQMVCGMPEISVEVLKKVVRYR-EV 2641
            Y  ++    +  A   G   +    +L L    +L+ MV G      + L+K   Y+ E 
Sbjct: 895  YIFNKSVASLFDAFHAGFHKVCGGKVLQLFQPNELQAMVIGNTNYDWKELEKNTEYKGEY 954

Query: 2642 DEQHQLVQWFWHTLEEFSNEERVLFMRFVSGRSRLPANTADISQRFQIMKVDRPYDSLPT 2821
              +H  ++ FW    E   E++  F+ F++G  R+P      S +  I       + LP 
Sbjct: 955  WAEHPTIKIFWEVFHELPLEKKKQFLLFLTGSDRIPI-LGMKSLKLVIQSTGGGEEYLPV 1013

Query: 2822 SQTCFFQLRLPPYSSQLVMAERLRYAINN 2908
            S TCF  L LP Y+ +  +  +L  AI++
Sbjct: 1014 SHTCFNLLDLPKYTEKETLRSKLIQAIDH 1042


>ref|XP_860046.1| PREDICTED: similar to hect domain and RLD 4 isoform b isoform 10
            [Canis familiaris].
          Length = 1055

 Score =  160 bits (406), Expect = 6e-39
 Identities = 105/314 (33%), Positives = 164/314 (52%), Gaps = 3/314 (0%)
 Frame = +2

Query: 542  VLACGEGSYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSD-GHSMALTESGEVFSW 718
            +L  G  S+G+LG G  D+  VL    +   F + + V   G    H++ + + G V++ 
Sbjct: 1    MLCWGNASFGQLGLGGIDEEIVLEPRKS--DFFINKKVRDVGCGLRHTVFVLDDGTVYTC 58

Query: 719  GDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRL 898
            G  D G+LGH  S  +++P Q+ AL  + +V +SCG  H+  +   G+++ +G    G+L
Sbjct: 59   GCNDLGQLGHEKS--RKKPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQL 116

Query: 899  GL-GNTSNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNST 1075
            GL G+    ++P  + +L   QI QVACG  H+LA+S   S V+ +G   YG+LGLG   
Sbjct: 117  GLLGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSK-ASEVFCWGQNKYGQLGLGIDC 175

Query: 1076 AK-SSPQKVDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGLPEGRARNHNRPQQ 1252
             K +SPQ +  L GI   +VA G   S  LT  G ++ +G+++   L      +   P  
Sbjct: 176  KKQASPQLIKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNL 235

Query: 1253 IPVLAGVVIEDVAVGAEHTLALASTGDVYAWGSNSEGQLGLGHTNHVREPTLVTVLQGKN 1432
            +  L    I  +  G +HT AL   G V+ +G+   GQLG   T+H   P  V  L G  
Sbjct: 236  LKSLRTQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSI 295

Query: 1433 VRQISAGRCHSAAW 1474
            V QI+ GR H++A+
Sbjct: 296  VTQIACGRQHTSAF 309



 Score =  159 bits (401), Expect = 2e-38
 Identities = 98/307 (31%), Positives = 160/307 (52%), Gaps = 3/307 (0%)
 Frame = +2

Query: 500  CGQNCTFVIQANGTVLACGEGSYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSDGH 679
            CG   T  +  +GTV  CG    G+LG   S       V    Q  V      SCG + H
Sbjct: 41   CGLRHTVFVLDDGTVYTCGCNDLGQLGHEKSRKKPEQVVALDAQNIV----AVSCG-EAH 95

Query: 680  SMALTESGEVFSWGDGDYGKLG-HGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSD 856
            ++AL + G+V++WG    G+LG  G+ +  R PR I++L   ++VQ++CG+ HS  ++  
Sbjct: 96   TLALNDKGQVYAWGLDSDGQLGLLGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKA 155

Query: 857  GKLFTFGNGDYGRLGLGNTSNKKL-PERVTALEGYQIGQVACGLNHTLAVSADGSMVWAF 1033
             ++F +G   YG+LGLG    K+  P+ + +L G    QVA G  H+  ++  G+ ++ +
Sbjct: 156  SEVFCWGQNKYGQLGLGIDCKKQASPQLIKSLLGIPFMQVAAGGAHSFVLTLSGA-IFGW 214

Query: 1034 GDGDYGKLGLGNSTAKSSPQKVDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGL 1213
            G   +G+LGL +   +  P  +  L    I  + CG   + ALTK+G V+TFG      L
Sbjct: 215  GRNKFGQLGLNDENDRYVPNLLKSLRTQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQL 274

Query: 1214 PEGRARNHNRPQQIPVLAGVVIEDVAVGAEHTLA-LASTGDVYAWGSNSEGQLGLGHTNH 1390
                  +   P+++  L G ++  +A G +HT A + S+G +Y++G    GQLG G T++
Sbjct: 275  GHNSTSHEINPRKVFELMGSIVTQIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSN 334

Query: 1391 VREPTLV 1411
             + P  V
Sbjct: 335  RKSPFTV 341



 Score =  146 bits (369), Expect = 1e-34
 Identities = 91/258 (35%), Positives = 137/258 (53%), Gaps = 4/258 (1%)
 Frame = +2

Query: 716  WGDGDYGKLGHGNSDRQ--RRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDY 889
            WG+  +G+LG G  D +    PR+ +    ++V  + CG +H+  V  DG ++T G  D 
Sbjct: 4    WGNASFGQLGLGGIDEEIVLEPRKSDFFINKKVRDVGCGLRHTVFVLDDGTVYTCGCNDL 63

Query: 890  GRLGLGNTSNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGL-G 1066
            G+LG  +  ++K PE+V AL+   I  V+CG  HTLA++ D   V+A+G    G+LGL G
Sbjct: 64   GQLG--HEKSRKKPEQVVALDAQNIVAVSCGEAHTLALN-DKGQVYAWGLDSDGQLGLLG 120

Query: 1067 NSTAKSSPQKVDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGLPEG-RARNHNR 1243
            +      P+ +  L  I I +VACG   S+AL+K   V+ +GQ++   L  G   +    
Sbjct: 121  SEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGIDCKKQAS 180

Query: 1244 PQQIPVLAGVVIEDVAVGAEHTLALASTGDVYAWGSNSEGQLGLGHTNHVREPTLVTVLQ 1423
            PQ I  L G+    VA G  H+  L  +G ++ WG N  GQLGL   N    P L+  L+
Sbjct: 181  PQLIKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLR 240

Query: 1424 GKNVRQISAGRCHSAAWT 1477
             + +  I  G  H+AA T
Sbjct: 241  TQKIVYICCGEDHTAALT 258



 Score =  127 bits (319), Expect = 7e-29
 Identities = 76/243 (31%), Positives = 117/243 (48%), Gaps = 5/243 (2%)
 Frame = +2

Query: 377  LGGKCDVYLWGAGRHGQLAEAGRNVMVXXXXXXXXXXXX----VICGQNCTFVIQANGTV 544
            L  K  VY WG    GQL   G    +                V CG   +  +     V
Sbjct: 99   LNDKGQVYAWGLDSDGQLGLLGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEV 158

Query: 545  LACGEGSYGRLGQGNSDDLHVLT-VISALQGFVVTQLVTSCGSDGHSMALTESGEVFSWG 721
               G+  YG+LG G          +I +L G    Q+        HS  LT SG +F WG
Sbjct: 159  FCWGQNKYGQLGLGIDCKKQASPQLIKSLLGIPFMQVAAG---GAHSFVLTLSGAIFGWG 215

Query: 722  DGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLG 901
               +G+LG  + + +  P  +++L+ +++V + CG  H+A +T +G +FTFG G YG+LG
Sbjct: 216  RNKFGQLGLNDENDRYVPNLLKSLRTQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLG 275

Query: 902  LGNTSNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNSTAK 1081
              +TS++  P +V  L G  + Q+ACG  HT A       +++FG G  G+LG G+++ +
Sbjct: 276  HNSTSHEINPRKVFELMGSIVTQIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSNR 335

Query: 1082 SSP 1090
             SP
Sbjct: 336  KSP 338



 Score =  111 bits (278), Expect = 4e-24
 Identities = 66/209 (31%), Positives = 110/209 (52%), Gaps = 8/209 (3%)
 Frame = +2

Query: 329 DEQIMSWATSRPEDWHLGGKCDVYLWGAGRHGQLA-------EAGRNVMVXXXXXXXXXX 487
           D QI+  A        L    +V+ WG  ++GQL        +A   ++           
Sbjct: 136 DIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGIDCKKQASPQLI---KSLLGIPF 192

Query: 488 XXVICGQNCTFVIQANGTVLACGEGSYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCG 667
             V  G   +FV+  +G +   G   +G+LG  + +D +V  ++ +L+     ++V  C 
Sbjct: 193 MQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLR---TQKIVYICC 249

Query: 668 SDGHSMALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKH-SAV 844
            + H+ ALT+ G VF++G G YG+LGH ++  +  PR++  L G  V Q++CG +H SA 
Sbjct: 250 GEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTQIACGRQHTSAF 309

Query: 845 VTSDGKLFTFGNGDYGRLGLGNTSNKKLP 931
           V S G++++FG G  G+LG G+TSN+K P
Sbjct: 310 VPSSGRIYSFGLGGNGQLGTGSTSNRKSP 338



 Score = 74.3 bits (181), Expect = 7e-13
 Identities = 78/329 (23%), Positives = 139/329 (42%), Gaps = 5/329 (1%)
 Frame = +2

Query: 1937 KVKLVGEGADDAGGVFDDTITEMCQELETGIVDLLIPSPNATAEVGYNRDRFL-FNPSAC 2113
            KV  VGE A DAGGV  +    + +EL           P       Y   R + F+    
Sbjct: 737  KVIFVGEDAVDAGGVRKEFFLLIMRELL---------DPKYGMFRYYEDSRLIWFSDKTF 787

Query: 2114 LDEHLMQFKFLGILMGVAIRTKKPLDLHLAPLVWKQLCCVPXXXXXXXXXXXXYVQTLNS 2293
             D  L  F  +G++ G+AI     +DLH    ++K+L                  +++  
Sbjct: 788  EDSDL--FHLIGVICGLAIYNFTIVDLHFPLALYKKLLKKKPSLDDLKELVPDVGRSMQQ 845

Query: 2294 ILHIEDSGITEESF--HEMIPLDSFVGQSADGKMVPIIPGGNSIPLTFSNRKEYVERAIE 2467
            +L   +  + EE+F  +  I +++F       ++  ++  G    +   NR+E+V+  ++
Sbjct: 846  LLDYPEDDV-EETFCLNFTITVENFGAT----EVKELVLNGADTAVNKQNRQEFVDAYVD 900

Query: 2468 YRLHEMDRQVA-AVREGMSWIVPVPLLSLLTAKQLEQMVCGMPEISVEVLKKVVRYR-EV 2641
            Y  ++    +  A   G   +    +L L    +L+ MV G      + L+K   Y+ E 
Sbjct: 901  YIFNKSVASLFDAFHAGFHKVCGGKVLQLFQPNELQAMVIGNTNYDWKELEKNTEYKGEY 960

Query: 2642 DEQHQLVQWFWHTLEEFSNEERVLFMRFVSGRSRLPANTADISQRFQIMKVDRPYDSLPT 2821
              +H  ++ FW    E   E++  F+ F++G  R+P      S +  I       + LP 
Sbjct: 961  WAEHPTIKIFWEVFHELPLEKKKQFLLFLTGSDRIPI-LGMKSLKLVIQSTGGGEEYLPV 1019

Query: 2822 SQTCFFQLRLPPYSSQLVMAERLRYAINN 2908
            S TCF  L LP Y+ +  +  +L  AI++
Sbjct: 1020 SHTCFNLLDLPKYTEKETLRSKLIQAIDH 1048


  Database: RefSeq49_CP.fasta
    Posted date:  Oct 17, 2011  1:42 PM
  Number of letters in database: 18,874,504
  Number of sequences in database:  33,336
  
Lambda     K      H
   0.318    0.134    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 33336
Number of Hits to DB: 140,338,798
Number of extensions: 3716523
Number of successful extensions: 12881
Number of sequences better than 1.0e-05: 96
Number of HSP's gapped: 12004
Number of HSP's successfully gapped: 208
Length of query: 1168
Length of database: 18,874,504
Length adjustment: 114
Effective length of query: 1054
Effective length of database: 15,074,200
Effective search space: 15888206800
Effective search space used: 15888206800
Neighboring words threshold: 12
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 36 (18.5 bits)

BLASTX 2.2.24 [Aug-08-2010]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= 20110601C-003115
         (3506 letters)

Database: RefSeq49_HP.fasta 
           32,964 sequences; 18,297,164 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

Alignment   gi|NP_003913.3| probable E3 ubiquitin-protein ligase HERC1 [Hom...  1968   0.0  
Alignment   gi|NP_004658.3| E3 ubiquitin-protein ligase HERC2 [Homo sapiens].    644   0.0  
Alignment   gi|NP_078878.3| E3 ubiquitin-protein ligase HECTD3 [Homo sapien...   191   4e-48
Alignment   gi|NP_055421.1| probable E3 ubiquitin-protein ligase HERC3 [Hom...   177   8e-44
Alignment   gi|NP_056416.2| probable E3 ubiquitin-protein ligase HERC4 isof...   160   6e-39
Alignment   gi|NP_071362.1| probable E3 ubiquitin-protein ligase HERC4 isof...   160   6e-39
Alignment   gi|NP_001259.1| RCC1 and BTB domain-containing protein 2 [Homo ...   152   2e-36
Alignment   gi|NP_000319.1| X-linked retinitis pigmentosa GTPase regulator ...   149   2e-35
Alignment   gi|NP_001030025.1| X-linked retinitis pigmentosa GTPase regulat...   149   2e-35
Alignment   gi|NP_001158608.1| probable E3 ubiquitin-protein ligase HERC6 i...   142   2e-33

>ref|NP_003913.3| probable E3 ubiquitin-protein ligase HERC1 [Homo sapiens].
          Length = 4861

 Score = 1968 bits (5098), Expect = 0.0
 Identities = 963/994 (96%), Positives = 966/994 (97%)
 Frame = +2

Query: 2    EKPHVVCGDQLVHSPYMQCLASLAVGLHLDQLLCNPPVPPHHQNCLPDPASWNPNEWAWL 181
            EKPHVVCGDQLVHSPYMQCLASLAVGLHLDQLLCNPPVPPHHQNCLPDPASWNPNEWAWL
Sbjct: 3868 EKPHVVCGDQLVHSPYMQCLASLAVGLHLDQLLCNPPVPPHHQNCLPDPASWNPNEWAWL 3927

Query: 182  ECFSTTIKAAEALTNGAQFPESFSVPDLEPVPEDELVFLMDNSKWINGMDEQIMSWATSR 361
            ECFSTTIKAAEALTNGAQFPESF+VPDLEPVPEDELVFLMDNSKWINGMDEQIMSWATSR
Sbjct: 3928 ECFSTTIKAAEALTNGAQFPESFTVPDLEPVPEDELVFLMDNSKWINGMDEQIMSWATSR 3987

Query: 362  PEDWHLGGKCDVYLWGAGRHGQLAEAGRNVMVXXXXXXXXXXXXVICGQNCTFVIQANGT 541
            PEDWHLGGKCDVYLWGAGRHGQLAEAGRNVMV            VICGQNCTFVIQANGT
Sbjct: 3988 PEDWHLGGKCDVYLWGAGRHGQLAEAGRNVMVPAAAPSFSQAQQVICGQNCTFVIQANGT 4047

Query: 542  VLACGEGSYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSDGHSMALTESGEVFSWG 721
            VLACGEGSYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSDGHSMALTESGEVFSWG
Sbjct: 4048 VLACGEGSYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSDGHSMALTESGEVFSWG 4107

Query: 722  DGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLG 901
            DGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLG
Sbjct: 4108 DGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLG 4167

Query: 902  LGNTSNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNSTAK 1081
            LGNTSNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNSTAK
Sbjct: 4168 LGNTSNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNSTAK 4227

Query: 1082 SSPQKVDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGLPEGRARNHNRPQQIPV 1261
            SSPQK+DVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGLPEGRARNHNRPQQIPV
Sbjct: 4228 SSPQKIDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGLPEGRARNHNRPQQIPV 4287

Query: 1262 LAGVVIEDVAVGAEHTLALASTGDVYAWGSNSEGQLGLGHTNHVREPTLVTVLQGKNVRQ 1441
            LAGV+IEDVAVGAEHTLALAS GDVYAWGSNSEGQLGLGHTNHVREPTLVT LQGKNVRQ
Sbjct: 4288 LAGVIIEDVAVGAEHTLALASNGDVYAWGSNSEGQLGLGHTNHVREPTLVTGLQGKNVRQ 4347

Query: 1442 ISAGRCHSAAWTAPPVPPRAPGVSVPLQLGLPDAVPPQYGALREVSIHTARARLRLLYHF 1621
            ISAGRCHSAAWTAPPVPPRAPGVSVPLQLGLPD VPPQYGALREVSIHT RARLRLLYHF
Sbjct: 4348 ISAGRCHSAAWTAPPVPPRAPGVSVPLQLGLPDTVPPQYGALREVSIHTVRARLRLLYHF 4407

Query: 1622 SDLMYSSWRLLNLSPNNQNSTSHYNAGTWGIVQGQLRPLLAPRVYTLPMVRSIGKTMVQG 1801
            SDLMYSSWRLLNLSPNNQNSTSHYNAGTWGIVQGQLRPLLAPRVYTLPMVRSIGKTMVQG
Sbjct: 4408 SDLMYSSWRLLNLSPNNQNSTSHYNAGTWGIVQGQLRPLLAPRVYTLPMVRSIGKTMVQG 4467

Query: 1802 KNYGPQITVKRISTRGRKCKPIFVQIARQVVKLNASDLRLPSRAWKVKLVGEGADDAGGV 1981
            KNYGPQITVKRISTRGRKCKPIFVQIARQVVKLNASDLRLPSRAWKVKLVGEGADDAGGV
Sbjct: 4468 KNYGPQITVKRISTRGRKCKPIFVQIARQVVKLNASDLRLPSRAWKVKLVGEGADDAGGV 4527

Query: 1982 FDDTITEMCQELETGIVDLLIPSPNATAEVGYNRDRFLFNPSACLDEHLMQFKFLGILMG 2161
            FDDTITEMCQELETGIVDLLIPSPNATAEVGYNRDRFLFNPSACLDEHLMQFKFLGILMG
Sbjct: 4528 FDDTITEMCQELETGIVDLLIPSPNATAEVGYNRDRFLFNPSACLDEHLMQFKFLGILMG 4587

Query: 2162 VAIRTKKPLDLHLAPLVWKQLCCVPXXXXXXXXXXXXYVQTLNSILHIEDSGITEESFHE 2341
            VAIRTKKPLDLHLAPLVWKQLCCVP            YVQTLNSILHIEDSGITEESFHE
Sbjct: 4588 VAIRTKKPLDLHLAPLVWKQLCCVPLTLEDLEEVDLLYVQTLNSILHIEDSGITEESFHE 4647

Query: 2342 MIPLDSFVGQSADGKMVPIIPGGNSIPLTFSNRKEYVERAIEYRLHEMDRQVAAVREGMS 2521
            MIPLDSFVGQSADGKMVPIIPGGNSIPLTFSNRKEYVERAIEYRLHEMDRQVAAVREGMS
Sbjct: 4648 MIPLDSFVGQSADGKMVPIIPGGNSIPLTFSNRKEYVERAIEYRLHEMDRQVAAVREGMS 4707

Query: 2522 WIVPVPLLSLLTAKQLEQMVCGMPEISVEVLKKVVRYREVDEQHQLVQWFWHTLEEFSNE 2701
            WIVPVPLLSLLTAKQLEQMVCGMPEISVEVLKKVVRYREVDEQHQLVQWFWHTLEEFSNE
Sbjct: 4708 WIVPVPLLSLLTAKQLEQMVCGMPEISVEVLKKVVRYREVDEQHQLVQWFWHTLEEFSNE 4767

Query: 2702 ERVLFMRFVSGRSRLPANTADISQRFQIMKVDRPYDSLPTSQTCFFQLRLPPYSSQLVMA 2881
            ERVLFMRFVSGRSRLPANTADISQRFQIMKVDRPYDSLPTSQTCFFQLRLPPYSSQLVMA
Sbjct: 4768 ERVLFMRFVSGRSRLPANTADISQRFQIMKVDRPYDSLPTSQTCFFQLRLPPYSSQLVMA 4827

Query: 2882 ERLRYAINNCRSIDMDNYMLSRNVDNAEGSDTDY 2983
            ERLRYAINNCRSIDMDNYMLSRNVDNAEGSDTDY
Sbjct: 4828 ERLRYAINNCRSIDMDNYMLSRNVDNAEGSDTDY 4861



 Score =  315 bits (806), Expect = 2e-85
 Identities = 167/369 (45%), Positives = 235/369 (63%), Gaps = 3/369 (0%)
 Frame = +2

Query: 389  CDVYLWGAGRHGQLAEAGRNVMVXXXXXXXXXXXXVI-CGQNCTFVIQANGTVLACGEGS 565
            C+VY+WG+    QL E  +  ++             I  GQ CTFVI  +G+V ACG+GS
Sbjct: 372  CEVYVWGSNSSHQLVEGTQEKILQPKLAPSFSDAQTIEAGQYCTFVISTDGSVRACGKGS 431

Query: 566  YGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSDGHSMALTESGEVFSWGDGDYGKLG 745
            YGRLG G+S++   L  ++      + ++ +S GSDGH++A T  GEVFSWGDGDYGKLG
Sbjct: 432  YGRLGLGDSNNQSTLKKLTFEPHRSIKKVSSSKGSDGHTLAFTTEGEVFSWGDGDYGKLG 491

Query: 746  HGNSDRQRRPRQIEA-LQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLGLGNTSNK 922
            HGNS  Q+ P+ I+  LQG+ VV +S G++HSA VT DG+L+T+G GD+GRLG G+++++
Sbjct: 492  HGNSSTQKYPKLIQGPLQGKVVVCVSAGYRHSAAVTEDGELYTWGEGDFGRLGHGDSNSR 551

Query: 923  KLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNSTAKSSPQKVD 1102
             +P  V  +    +G+V+CG +HT+A+S DG  VW+FG GD GKLG G++     P+ ++
Sbjct: 552  NIPTLVKDIS--NVGEVSCGSSHTIALSKDGRTVWSFGGGDNGKLGHGDTNRVYKPKVIE 609

Query: 1103 VLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGLPEGRARNHNRPQQIPVLAGVVIE 1282
             L G+ I+KV  G+Q S+ALT  G VY +G    +G     A    RP+ I  LA   I 
Sbjct: 610  ALQGMFIRKVCAGSQSSLALTSTGQVYAWGCGACLGCGSSEA-TALRPKLIEELAATRIV 668

Query: 1283 DVAVGAEHTLALASTGDVYAWGSNSEGQLGLGH-TNHVREPTLVTVLQGKNVRQISAGRC 1459
            DV++G  H LAL+   +VYAWG+NS GQ G G+ T  + +P  V+ L G  ++QISAG  
Sbjct: 669  DVSIGDSHCLALSHDNEVYAWGNNSMGQCGQGNSTGPITKPKKVSGLDGIAIQQISAGTS 728

Query: 1460 HSAAWTAPP 1486
            HS AWTA P
Sbjct: 729  HSLAWTALP 737


>ref|NP_004658.3| E3 ubiquitin-protein ligase HERC2 [Homo sapiens].
          Length = 4834

 Score =  644 bits (1660), Expect = 0.0
 Identities = 388/1007 (38%), Positives = 544/1007 (54%), Gaps = 29/1007 (2%)
 Frame = +2

Query: 2    EKPHVVCGDQLVHSPYMQCLASLAVGLHLDQLLCNPPVPPHHQNCLPDPASWNPNEWAWL 181
            E P V  G QL+HSP+ + L +LA  L LD L C          C         ++WAW 
Sbjct: 3831 EDPIVRGGKQLLHSPFFKVLVALACDLELDTLPC----------CA------ETHKWAWF 3874

Query: 182  ECFSTTIKAAEALTNGAQFPESF------SVPDLEPVPEDELVFLMDNSKWINGMDEQIM 343
              +    + A AL      P  F       + +L    E+  V    +  +    DEQ++
Sbjct: 3875 RRYCMASRVAVALDKRTPLPRLFLDEVAKKIRELMADSENMDVLHESHDIFKREQDEQLV 3934

Query: 344  SWATSRPEDWHL--GGKCDVYLWGAGRHGQLAEA-GRNVMVXXXXXXXXXXXXV--ICGQ 508
             W   RP+DW L  GG   +Y WG    GQL    G  V V            V  I G+
Sbjct: 3935 QWMNRRPDDWTLSAGGSGTIYGWGHNHRGQLGGIEGAKVKVPTPCEALATLRPVQLIGGE 3994

Query: 509  NCTFVIQANGTVLACGEGSYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSDGHSMA 688
               F + A+G + A G G+ GRLG G ++ +   T++ ++Q   + ++  + G   H +A
Sbjct: 3995 QTLFAVTADGKLYATGYGAGGRLGIGGTESVSTPTLLESIQHVFIKKVAVNSGGK-HCLA 4053

Query: 689  LTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLF 868
            L+  GEV+SWG+ + GKLGHGN     RPR IE+L+G EVV ++ G  HSA VT+ G L+
Sbjct: 4054 LSSEGEVYSWGEAEDGKLGHGNRSPCDRPRVIESLRGIEVVDVAAGGAHSACVTAAGDLY 4113

Query: 869  TFGNGDYGRLGLGNTSNKKLPERVTALEGYQIGQVACGLN--HTLAVSADGSMVWAFGDG 1042
            T+G G YGRLG  ++ ++  P+ V AL+G+++  +ACG     TL ++ D + VW++GDG
Sbjct: 4114 TWGKGRYGRLGHSDSEDQLKPKLVEALQGHRVVDIACGSGDAQTLCLTDDDT-VWSWGDG 4172

Query: 1043 DYGKLGLGNSTAKSSPQKVDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGLPEG 1222
            DYGKLG G S     P K+D L G+G+ KV CG+QFSVALTK G VYT+G+     L  G
Sbjct: 4173 DYGKLGRGGSDGCKVPMKIDSLTGLGVVKVECGSQFSVALTKSGAVYTWGKGDYHRLGHG 4232

Query: 1223 RARNHNRPQQIPVLAGVVIEDVAVGAEHTLALASTGDVYAWGSNSEGQLGLGHTNHVREP 1402
               +  RP+Q+  L G  +  +A G+ H +     G+VY WG N EGQLG G TN ++ P
Sbjct: 4233 SDDHVRRPRQVQGLQGKKVIAIATGSLHCVCCTEDGEVYTWGDNDEGQLGDGTTNAIQRP 4292

Query: 1403 TLVTVLQGKNVRQISAGRCHSAAWTAPPVPPRAPGVSVPLQLG-LPDAVPPQYGALREVS 1579
             LV  LQGK V +++ G  H+ AW+           S P   G LP  VP +Y  L+E+ 
Sbjct: 4293 RLVAALQGKKVNRVACGSAHTLAWS----------TSKPASAGKLPAQVPMEYNHLQEIP 4342

Query: 1580 IHTARARLRLLYHFSDLMYSSWRLLNLSPNNQNSTSHYNAGTWGIVQGQLRPLLAPRVYT 1759
            I   R RL LL+H S+L      + +L    + S      G   +    LR +L  +   
Sbjct: 4343 IIALRNRLLLLHHLSELFCPCIPMFDL----EGSLDETGLGP-SVGFDTLRGILISQGKE 4397

Query: 1760 LPMVRSIGKTMVQGKNYGPQITVKRISTRGRK----------CKPIFVQIARQVVKLNAS 1909
                + +  TMV+ + +GP + + RI  +  +           K +F Q+  ++      
Sbjct: 4398 AAFRKVVQATMVRDRQHGPVVELNRIQVKRSRSKGGLAGPDGTKSVFGQMCAKMSSFGPD 4457

Query: 1910 DLRLPSRAWKVKLVGEGADDAGGVFDDTITEMCQELETGIVDLLIPSPNATAEVGYNRDR 2089
             L LP R WKVK VGE  DD GG + ++I E+C+EL+ G+  LLI +PN   E G NRD 
Sbjct: 4458 SLLLPHRVWKVKFVGESVDDCGGGYSESIAEICEELQNGLTPLLIVTPNGRDESGANRDC 4517

Query: 2090 FLFNPSACLDEHLMQFKFLGILMGVAIRTKKPLDLHLAPLVWKQLCCVPXXXXXXXXXXX 2269
            +L +P+A    H   F+FLG+L+G+AIRT  PL L+LA  VWKQL  +            
Sbjct: 4518 YLLSPAARAPVHSSMFRFLGVLLGIAIRTGSPLSLNLAEPVWKQLAGMSLTIADLSEVDK 4577

Query: 2270 XYVQTLNSILHIEDSGITEESFHEM-IPLDSFVGQSADGKMVPIIPGGNSIPLTFSNRKE 2446
             ++     +++I D+  T E F  M +P   F   SA G+ + +        +T  NR E
Sbjct: 4578 DFIP---GLMYIRDNEATSEEFEAMSLP---FTVPSASGQDIQL--SSKHTHITLDNRAE 4629

Query: 2447 YVERAIEYRLHEMDRQVAAVREGMSWIVPVPLLSLLTAKQLEQMVCGMPEISVEVLKKVV 2626
            YV  AI YRLHE D QVAAVREGM+ +VPVPLLSL T  +LE MVCG P+I + +LK V 
Sbjct: 4630 YVRLAINYRLHEFDEQVAAVREGMARVVPVPLLSLFTGYELETMVCGSPDIPLHLLKSVA 4689

Query: 2627 RYREVDEQHQLVQWFWHTLEEFSNEERVLFMRFVSGRSRLPANTADISQR-FQIMKVDR- 2800
             Y+ ++    L+QWFW  +E FSN ER LF+RFV GR+RLP   AD   R F I  +D+ 
Sbjct: 4690 TYKGIEPSASLIQWFWEVMESFSNTERSLFLRFVWGRTRLPRTIADFRGRDFVIQVLDKY 4749

Query: 2801 --PYDSLPTSQTCFFQLRLPPYSSQLVMAERLRYAINNCRSIDMDNY 2935
              P   LP S TCFF L+LP YS + V+ E+L+YAI+ C+SID D+Y
Sbjct: 4750 NPPDHFLPESYTCFFLLKLPRYSCKQVLEEKLKYAIHFCKSIDTDDY 4796



 Score =  263 bits (673), Expect = 6e-70
 Identities = 147/343 (42%), Positives = 209/343 (60%), Gaps = 3/343 (0%)
 Frame = +2

Query: 503  GQNCTFVIQANGTVLACGEGSYGRLGQG-NSDDLHVLTVISALQGFVVTQLVTSCGSDGH 679
            G    F +   G V ACGE + GRLG G +S  + +   I+AL  +VV ++    G   H
Sbjct: 3000 GSKSLFAVTVEGKVYACGEATNGRLGLGISSGTVPIPRQITALSSYVVKKVAVHSGGR-H 3058

Query: 680  SMALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDG 859
            + ALT  G+VFSWG+GD GKLGH +     +PR IEAL+ + +  ++CG  HSA +TS G
Sbjct: 3059 ATALTVDGKVFSWGEGDDGKLGHFSRMNCDKPRLIEALKTKRIRDIACGSSHSAALTSSG 3118

Query: 860  KLFTFGNGDYGRLGLGNTSNKKLPERVTALEGYQIGQVACGLN--HTLAVSADGSMVWAF 1033
            +L+T+G G+YGRLG G+ + +  P+ V  L G+++ QVACG     TLA++ +G +V+++
Sbjct: 3119 ELYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEG-LVFSW 3177

Query: 1034 GDGDYGKLGLGNSTAKSSPQKVDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGL 1213
            GDGD+GKLG G S   + PQ ++ L G G+ ++ CG QFS+ALTK G V+T+G+     L
Sbjct: 3178 GDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFSLALTKSGVVWTWGKGDYFRL 3237

Query: 1214 PEGRARNHNRPQQIPVLAGVVIEDVAVGAEHTLALASTGDVYAWGSNSEGQLGLGHTNHV 1393
              G   +  +PQ +  L G  I  VAVGA H LA+  +G VYAWG N  GQ G G T   
Sbjct: 3238 GHGSDVHVRKPQVVEGLRGKKIVHVAVGALHCLAVTDSGQVYAWGDNDHGQQGNGTTTVN 3297

Query: 1394 REPTLVTVLQGKNVRQISAGRCHSAAWTAPPVPPRAPGVSVPL 1522
            R+PTLV  L+G+ + +++ G  HS AWT   V    P V  P+
Sbjct: 3298 RKPTLVQGLEGQKITRVACGSSHSVAWTT--VDVATPSVHEPV 3338



 Score =  209 bits (533), Expect = 1e-53
 Identities = 129/343 (37%), Positives = 194/343 (56%), Gaps = 20/343 (5%)
 Frame = +2

Query: 512  CTFVIQANGTVLACGEGSYGRLGQG--------NSDDLHVLTVISALQGFVVTQLVT-SC 664
            C  +     T +AC E  +  L +         NSD L    V    QG     +V  + 
Sbjct: 445  CEGLANLGVTQIACAEKRFLILSRNGRVYTQAYNSDTLAPQLV----QGLASRNIVKIAA 500

Query: 665  GSDGHS-MALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEE----VVQMSCGF 829
             SDGH  +AL  +GEV+SWG GD G+LGHG++     P+ I A  G++    VV ++CG 
Sbjct: 501  HSDGHHYLALAATGEVYSWGCGDGGRLGHGDTVPLEEPKVISAFSGKQAGKHVVHIACGS 560

Query: 830  KHSAVVTSDGKLFTFGNGDYGRLGLGNTSNKKLPERVTALEGYQIGQVACGLN--HTLAV 1003
             +SA +T++G+L+T+G G+YGRLG G++ ++ +P  V  L+G ++  VACG     TLAV
Sbjct: 561  TYSAAITAEGELYTWGRGNYGRLGHGSSEDEAIPMLVAGLKGLKVIDVACGSGDAQTLAV 620

Query: 1004 SADGSMVWAFGDGDYGKLGLGNSTAKSSPQKVDVLCGIGIKKVACGTQFSVALTKDGHVY 1183
            + +G  VW++GDGDYGKLG G S    +P+ ++ L  + + KV CG+QFS+ALTKDG VY
Sbjct: 621  TENGQ-VWSWGDGDYGKLGRGGSDGCKTPKLIEKLQDLDVVKVRCGSQFSIALTKDGQVY 679

Query: 1184 TFGQDRLIGLPEGRARNHNRPQQIPVLAGVVIEDVAVGAEHTLALASTGDVYAWGSNSEG 1363
            ++G+     L  G   +   P+ +  L G  + DVA G+ H LAL    +V++WGSN + 
Sbjct: 680  SWGKGDNQRLGHGTEEHVRYPKLLEGLQGKKVIDVAAGSTHCLALTEDSEVHSWGSNDQC 739

Query: 1364 QLGLGHTNHVR----EPTLVTVLQGKNVRQISAGRCHSAAWTA 1480
            Q    H + +R    EP  +  L  K++  I+ G   S AW++
Sbjct: 740  Q----HFDTLRVTKPEPAALPGLDTKHIVGIACGPAQSFAWSS 778



 Score =  166 bits (421), Expect = 1e-40
 Identities = 100/261 (38%), Positives = 142/261 (54%), Gaps = 4/261 (1%)
 Frame = +2

Query: 395  VYLWGAGRHGQLAEAGR---NVMVXXXXXXXXXXXXVICGQNCTFVIQANGTVLACGEGS 565
            V+ WG G  G+L    R   +               + CG + +  + ++G +   G G 
Sbjct: 3068 VFSWGEGDDGKLGHFSRMNCDKPRLIEALKTKRIRDIACGSSHSAALTSSGELYTWGLGE 3127

Query: 566  YGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGS-DGHSMALTESGEVFSWGDGDYGKL 742
            YGRLG G++       ++  L G  V Q+  +CGS D  ++ALT+ G VFSWGDGD+GKL
Sbjct: 3128 YGRLGHGDNTTQLKPKMVKVLLGHRVIQV--ACGSRDAQTLALTDEGLVFSWGDGDFGKL 3185

Query: 743  GHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLGLGNTSNK 922
            G G S+    P+ IE L G+ V Q+ CG + S  +T  G ++T+G GDY RLG G+  + 
Sbjct: 3186 GRGGSEGCNIPQNIERLNGQGVCQIECGAQFSLALTKSGVVWTWGKGDYFRLGHGSDVHV 3245

Query: 923  KLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNSTAKSSPQKVD 1102
            + P+ V  L G +I  VA G  H LAV+ D   V+A+GD D+G+ G G +T    P  V 
Sbjct: 3246 RKPQVVEGLRGKKIVHVAVGALHCLAVT-DSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQ 3304

Query: 1103 VLCGIGIKKVACGTQFSVALT 1165
             L G  I +VACG+  SVA T
Sbjct: 3305 GLEGQKITRVACGSSHSVAWT 3325



 Score =  158 bits (400), Expect = 3e-38
 Identities = 117/399 (29%), Positives = 187/399 (46%), Gaps = 34/399 (8%)
 Frame = +2

Query: 65   SLAVGLHLDQLL--CNPPV---PPHHQNCLPDPASWNPNEWAW-------LECFS----- 193
            ++ V  HLD+L   C PP+   P  H+  L +   W    W +       ++C       
Sbjct: 393  AVVVMAHLDRLATPCMPPLCSSPTSHKGSLQEVIGWGLIGWKYYANVIGPIQCEGLANLG 452

Query: 194  -TTIKAAEAL-----TNGAQFPESFSVPDLEPVPEDELVFLMDNSKWINGMDEQIMSWAT 355
             T I  AE        NG  + ++++   L P             + + G+  + +    
Sbjct: 453  VTQIACAEKRFLILSRNGRVYTQAYNSDTLAP-------------QLVQGLASRNIVKIA 499

Query: 356  SRPEDWH---LGGKCDVYLWGAGRHGQLA-------EAGRNVMVXXXXXXXXXXXXVICG 505
            +  +  H   L    +VY WG G  G+L        E  + +              + CG
Sbjct: 500  AHSDGHHYLALAATGEVYSWGCGDGGRLGHGDTVPLEEPKVISAFSGKQAGKHVVHIACG 559

Query: 506  QNCTFVIQANGTVLACGEGSYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGS-DGHS 682
               +  I A G +   G G+YGRLG G+S+D  +  +++ L+G  V  +  +CGS D  +
Sbjct: 560  STYSAAITAEGELYTWGRGNYGRLGHGSSEDEAIPMLVAGLKGLKVIDV--ACGSGDAQT 617

Query: 683  MALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGK 862
            +A+TE+G+V+SWGDGDYGKLG G SD  + P+ IE LQ  +VV++ CG + S  +T DG+
Sbjct: 618  LAVTENGQVWSWGDGDYGKLGRGGSDGCKTPKLIEKLQDLDVVKVRCGSQFSIALTKDGQ 677

Query: 863  LFTFGNGDYGRLGLGNTSNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDG 1042
            ++++G GD  RLG G   + + P+ +  L+G ++  VA G  H LA++ D S V ++G  
Sbjct: 678  VYSWGKGDNQRLGHGTEEHVRYPKLLEGLQGKKVIDVAAGSTHCLALTED-SEVHSWGSN 736

Query: 1043 DYGKLGLGNSTAKSSPQKVDVLCGIGIKKVACGTQFSVA 1159
            D  +        K  P  +  L    I  +ACG   S A
Sbjct: 737  DQCQHFDTLRVTKPEPAALPGLDTKHIVGIACGPAQSFA 775



 Score =  138 bits (347), Expect = 4e-32
 Identities = 95/273 (34%), Positives = 136/273 (49%), Gaps = 5/273 (1%)
 Frame = +2

Query: 674  GHSMALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTS 853
            G   A T   +VF WG  D  +LG     + + P   E L    VVQ++ G K    VT 
Sbjct: 2950 GLESAATIRTKVFVWGLNDKDQLGGLKGSKIKVPSFSETLSALNVVQVAGGSKSLFAVTV 3009

Query: 854  DGKLFTFGNGDYGRLGLGNTSNK-KLPERVTALEGYQIGQVA--CGLNHTLAVSADGSMV 1024
            +GK++  G    GRLGLG +S    +P ++TAL  Y + +VA   G  H  A++ DG  V
Sbjct: 3010 EGKVYACGEATNGRLGLGISSGTVPIPRQITALSSYVVKKVAVHSGGRHATALTVDGK-V 3068

Query: 1025 WAFGDGDYGKLGLGNSTAKSSPQKVDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRL 1204
            +++G+GD GKLG  +      P+ ++ L    I+ +ACG+  S ALT  G +YT+G    
Sbjct: 3069 FSWGEGDDGKLGHFSRMNCDKPRLIEALKTKRIRDIACGSSHSAALTSSGELYTWGLGEY 3128

Query: 1205 IGLPEGRARNHNRPQQIPVLAGVVIEDVAVGAE--HTLALASTGDVYAWGSNSEGQLGLG 1378
              L  G      +P+ + VL G  +  VA G+    TLAL   G V++WG    G+LG G
Sbjct: 3129 GRLGHGDNTTQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFSWGDGDFGKLGRG 3188

Query: 1379 HTNHVREPTLVTVLQGKNVRQISAGRCHSAAWT 1477
             +     P  +  L G+ V QI  G   S A T
Sbjct: 3189 GSEGCNIPQNIERLNGQGVCQIECGAQFSLALT 3221



 Score = 68.6 bits (166), Expect = 4e-11
 Identities = 46/139 (33%), Positives = 73/139 (52%), Gaps = 8/139 (5%)
 Frame = +2

Query: 1088 PQKVDVLCGIGIKKVACGTQFSVALTKDGHVYT--FGQDRLIGLPEGRARNHNRPQQIPV 1261
            P + + L  +G+ ++AC  +  + L+++G VYT  +  D L             PQ +  
Sbjct: 442  PIQCEGLANLGVTQIACAEKRFLILSRNGRVYTQAYNSDTL------------APQLVQG 489

Query: 1262 LAGVVIEDVAVGAE--HTLALASTGDVYAWGSNSEGQLGLGHTNHVREPTLVTVLQ---- 1423
            LA   I  +A  ++  H LALA+TG+VY+WG    G+LG G T  + EP +++       
Sbjct: 490  LASRNIVKIAAHSDGHHYLALAATGEVYSWGCGDGGRLGHGDTVPLEEPKVISAFSGKQA 549

Query: 1424 GKNVRQISAGRCHSAAWTA 1480
            GK+V  I+ G  +SAA TA
Sbjct: 550  GKHVVHIACGSTYSAAITA 568


>ref|NP_078878.3| E3 ubiquitin-protein ligase HECTD3 [Homo sapiens].
          Length = 861

 Score =  191 bits (485), Expect = 4e-48
 Identities = 123/349 (35%), Positives = 182/349 (52%), Gaps = 9/349 (2%)
 Frame = +2

Query: 1910 DLRLPSRA---WKVKLVGEGADDAGGVFDDTITEMCQELETGIVDLLIPSP------NAT 2062
            D R P R    W+ K + EG  D GG F D++ +M +EL     D  +P P      N  
Sbjct: 517  DYRWPMRYDQWWECKFIAEGIIDQGGGFRDSLADMSEELCPSSADTPVPLPFFVRTANQG 576

Query: 2063 AEVGYNRDRFLFNPSACLDEHLMQFKFLGILMGVAIRTKKPLDLHLAPLVWKQLCCVPXX 2242
               G  RD ++ NPS C D    +++++G LMG A+R K+ L L L   VWKQL      
Sbjct: 577  NGTGEARDMYVPNPS-CRD--FAKYEWIGQLMGAALRGKEFLVLALPGFVWKQLSGEEVS 633

Query: 2243 XXXXXXXXXXYVQTLNSILHIEDSGITEESFHEMIPLDSFVGQSADGKMVPIIPGGNSIP 2422
                       +  L  ++   D    E  F + +   +F    +D ++V +IPGG  I 
Sbjct: 634  WSKDFPAVDSVLVKLLEVMEGMDKETFEFKFGKEL---TFTTVLSDQQVVELIPGGAGIV 690

Query: 2423 LTFSNRKEYVERAIEYRLHEMDRQVAAVREGMSWIVPVPLLSLLTAKQLEQMVCGMPEIS 2602
            + + +R  +++   + RL E   QVAA++ G+  +VP  +L LLT ++LE+ VCG PE++
Sbjct: 691  VGYGDRSRFIQLVQKARLEESKEQVAAMQAGLLKVVPQAVLDLLTWQELEKKVCGDPEVT 750

Query: 2603 VEVLKKVVRYREVDEQHQLVQWFWHTLEEFSNEERVLFMRFVSGRSRLPANTADISQRFQ 2782
            V+ L+K+ R+ + +     VQ+FW  L  F+NE+R  F+RFV+GRSRLPA       +  
Sbjct: 751  VDALRKLTRFEDFEPSDSRVQYFWEALNNFTNEDRSRFLRFVTGRSRLPARIYIYPDKLG 810

Query: 2783 IMKVDRPYDSLPTSQTCFFQLRLPPYSSQLVMAERLRYAINNCRSIDMD 2929
                    D+LP S TC   L LP Y+S  V  E+LRYA  NC +ID D
Sbjct: 811  Y----ETTDALPESSTCSSTLFLPHYASAKVCEEKLRYAAYNCVAIDTD 855


>ref|NP_055421.1| probable E3 ubiquitin-protein ligase HERC3 [Homo sapiens].
          Length = 1050

 Score =  177 bits (448), Expect = 8e-44
 Identities = 113/325 (34%), Positives = 178/325 (54%), Gaps = 6/325 (1%)
 Frame = +2

Query: 494  VICGQNCTFVIQANGTVLACGEGSYGRLG---QGNSDDLHVLTVISALQGFVVTQLVTSC 664
            V CG N +  +  +G V  CG  + G+LG   +GN  +      I AL    +  +  +C
Sbjct: 39   VACGGNHSVFLLEDGEVYTCGLNTKGQLGHEREGNKPEQ-----IGALADQHIIHV--AC 91

Query: 665  GSDGHSMALTESGEVFSWGDGDYGKLG-HGNSDRQRRPRQIEALQGEEVVQMSCGFKHSA 841
            G + HS+AL++ G++FSWG G  G+LG     D    PR I+ L  + ++Q+SCG  H  
Sbjct: 92   G-ESHSLALSDRGQLFSWGAGSDGQLGLMTTEDSVAVPRLIQKLNQQTILQVSCGNWHCL 150

Query: 842  VVTSDGKLFTFGNGDYGRLGLGNT-SNKKLPERVTALEGYQIGQVACGLNHTLAVSADGS 1018
             + +DG+ FT+G   +G+LGLG    ++  P+RV +LEG  + QVA G  H+ A+S  G+
Sbjct: 151  ALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLSGA 210

Query: 1019 MVWAFGDGDYGKLGLGNSTAKSSPQKVDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQD 1198
             V+ +G  + G+LGL +   + SP  V +L    +  ++CG + +  LTK G V+TFG  
Sbjct: 211  -VFGWGMNNAGQLGLSDEKDRESPCHVKLLRTQKVVYISCGEEHTAVLTKSGGVFTFGAG 269

Query: 1199 RLIGLPEGRARNHNRPQQIPVLAGVVIEDVAVGAEHTLALA-STGDVYAWGSNSEGQLGL 1375
                L      +   P+++  L G  +  +A G +HTLA   S+G +YA+G  + GQLG 
Sbjct: 270  SCGQLGHDSMNDEVNPRRVLELMGSEVTQIACGRQHTLAFVPSSGLIYAFGCGARGQLGT 329

Query: 1376 GHTNHVREPTLVTVLQGKNVRQISA 1450
            GHT +V+ P+ V      +  Q+SA
Sbjct: 330  GHTCNVKCPSPVKGYWAAHSGQLSA 354



 Score =  157 bits (397), Expect = 6e-38
 Identities = 106/308 (34%), Positives = 163/308 (52%), Gaps = 5/308 (1%)
 Frame = +2

Query: 566  YGRLGQ-GNSDDLHVLTVISALQGFVVTQLV--TSCGSDGHSMALTESGEVFSWGDGDYG 736
            Y  LGQ G S +L  +     + GF+  + V   +CG + HS+ L E GEV++ G    G
Sbjct: 6    YWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGN-HSVFLLEDGEVYTCGLNTKG 64

Query: 737  KLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLGLGNTS 916
            +LGH       +P QI AL  + ++ ++CG  HS  ++  G+LF++G G  G+LGL  T 
Sbjct: 65   QLGHEREGN--KPEQIGALADQHIIHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTE 122

Query: 917  NK-KLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNS-TAKSSP 1090
            +   +P  +  L    I QV+CG  H LA++ADG   + +G   +G+LGLG    +++SP
Sbjct: 123  DSVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQF-FTWGKNSHGQLGLGKEFPSQASP 181

Query: 1091 QKVDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGLPEGRARNHNRPQQIPVLAG 1270
            Q+V  L GI + +VA G   S AL+  G V+ +G +    L     ++   P  + +L  
Sbjct: 182  QRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEKDRESPCHVKLLRT 241

Query: 1271 VVIEDVAVGAEHTLALASTGDVYAWGSNSEGQLGLGHTNHVREPTLVTVLQGKNVRQISA 1450
              +  ++ G EHT  L  +G V+ +G+ S GQLG    N    P  V  L G  V QI+ 
Sbjct: 242  QKVVYISCGEEHTAVLTKSGGVFTFGAGSCGQLGHDSMNDEVNPRRVLELMGSEVTQIAC 301

Query: 1451 GRCHSAAW 1474
            GR H+ A+
Sbjct: 302  GRQHTLAF 309



 Score =  132 bits (333), Expect = 2e-30
 Identities = 83/262 (31%), Positives = 127/262 (48%), Gaps = 5/262 (1%)
 Frame = +2

Query: 329  DEQIMSWATSRPEDWHLGGKCDVYLWGAGRHGQLA----EAGRNVMVXXXXXXXXXXXXV 496
            D+ I+  A        L  +  ++ WGAG  GQL     E    V              V
Sbjct: 83   DQHIIHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTEDSVAVPRLIQKLNQQTILQV 142

Query: 497  ICGQNCTFVIQANGTVLACGEGSYGRLGQGNSDDLHVLTV-ISALQGFVVTQLVTSCGSD 673
             CG      + A+G     G+ S+G+LG G           + +L+G  + Q+       
Sbjct: 143  SCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAG---G 199

Query: 674  GHSMALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTS 853
             HS AL+ SG VF WG  + G+LG  +   +  P  ++ L+ ++VV +SCG +H+AV+T 
Sbjct: 200  AHSFALSLSGAVFGWGMNNAGQLGLSDEKDRESPCHVKLLRTQKVVYISCGEEHTAVLTK 259

Query: 854  DGKLFTFGNGDYGRLGLGNTSNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAF 1033
             G +FTFG G  G+LG  + +++  P RV  L G ++ Q+ACG  HTLA      +++AF
Sbjct: 260  SGGVFTFGAGSCGQLGHDSMNDEVNPRRVLELMGSEVTQIACGRQHTLAFVPSSGLIYAF 319

Query: 1034 GDGDYGKLGLGNSTAKSSPQKV 1099
            G G  G+LG G++     P  V
Sbjct: 320  GCGARGQLGTGHTCNVKCPSPV 341



 Score =  122 bits (307), Expect = 2e-27
 Identities = 79/237 (33%), Positives = 126/237 (53%), Gaps = 2/237 (0%)
 Frame = +2

Query: 773  PRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLGLGNTSNKKLPERVTALE 952
            P+    +    V +++CG  HS  +  DG+++T G    G+LG     NK  PE++ AL 
Sbjct: 25   PQVCGFISDRSVKEVACGGNHSVFLLEDGEVYTCGLNTKGQLGHEREGNK--PEQIGALA 82

Query: 953  GYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNST-AKSSPQKVDVLCGIGIKK 1129
               I  VACG +H+LA+S D   ++++G G  G+LGL  +  + + P+ +  L    I +
Sbjct: 83   DQHIIHVACGESHSLALS-DRGQLFSWGAGSDGQLGLMTTEDSVAVPRLIQKLNQQTILQ 141

Query: 1130 VACGTQFSVALTKDGHVYTFGQDRLIGLPEGRA-RNHNRPQQIPVLAGVVIEDVAVGAEH 1306
            V+CG    +AL  DG  +T+G++    L  G+   +   PQ++  L G+ +  VA G  H
Sbjct: 142  VSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAH 201

Query: 1307 TLALASTGDVYAWGSNSEGQLGLGHTNHVREPTLVTVLQGKNVRQISAGRCHSAAWT 1477
            + AL+ +G V+ WG N+ GQLGL        P  V +L+ + V  IS G  H+A  T
Sbjct: 202  SFALSLSGAVFGWGMNNAGQLGLSDEKDRESPCHVKLLRTQKVVYISCGEEHTAVLT 258



 Score = 96.3 bits (238), Expect = 2e-19
 Identities = 88/337 (26%), Positives = 146/337 (43%), Gaps = 4/337 (1%)
 Frame = +2

Query: 1910 DLRLPSRAWKVKLVGEGADDAGGVFDDTITEMCQELETGIVDLLIPSPNATAEVGYNRDR 2089
            DL+ P    KV   GE A DAGGV  +    + +EL   I  +            Y    
Sbjct: 726  DLKKPL---KVIFDGEEAVDAGGVTKEFFLLLLKELLNPIYGMF---------TYYQDSN 773

Query: 2090 FLFNPSACLDEHLMQFKFLGILMGVAIRTKKPLDLHLAPLVWKQLCCVPXXXXXXXXXXX 2269
             L+    C  EH   F  +GI  G+AI     +DLH    ++K+L  V            
Sbjct: 774  LLWFSDTCFVEHNW-FHLIGITCGLAIYNSTVVDLHFPLALYKKLLNVKPGLEDLKELSP 832

Query: 2270 XYVQTLNSILHIEDSGITEESFHEMIPLDSFVGQSADG--KMVPIIPGGNSIPLTFSNRK 2443
               ++L  +L      + EE+F     L+  + + + G  +   +IPGG+++ +   NR+
Sbjct: 833  TEGRSLQELLDYPGEDV-EETFC----LNFTICRESYGVIEQKKLIPGGDNVTVCKDNRQ 887

Query: 2444 EYVERAIEYRLH-EMDRQVAAVREGMSWIVPVPLLSLLTAKQLEQMVCGMPEISVEVLKK 2620
            E+V+  + Y     +     A   G   +    +L L    +L  M+ G    + E L++
Sbjct: 888  EFVDAYVNYVFQISVHEWYTAFSSGFLKVCGGKVLELFQPSELRAMMVGNSNYNWEELEE 947

Query: 2621 VVRYR-EVDEQHQLVQWFWHTLEEFSNEERVLFMRFVSGRSRLPANTADISQRFQIMKVD 2797
               Y+ +    H  V+ FW T  EF  E++  F+ F++G  R+P      S +  I    
Sbjct: 948  TAIYKGDYSATHPTVKLFWETFHEFPLEKKKKFLLFLTGSDRIPI-YGMASLQIVIQSTA 1006

Query: 2798 RPYDSLPTSQTCFFQLRLPPYSSQLVMAERLRYAINN 2908
               + LP + TC+  L LP YSS+ +++ RL  A++N
Sbjct: 1007 SGEEYLPVAHTCYNLLDLPKYSSKEILSARLTQALDN 1043


>ref|NP_056416.2| probable E3 ubiquitin-protein ligase HERC4 isoform b [Homo sapiens].
          Length = 1049

 Score =  160 bits (406), Expect = 6e-39
 Identities = 104/314 (33%), Positives = 164/314 (52%), Gaps = 3/314 (0%)
 Frame = +2

Query: 542  VLACGEGSYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSD-GHSMALTESGEVFSW 718
            +L  G  S+G+LG G  D+  VL    +   F + + V   G    H++ + + G V++ 
Sbjct: 1    MLCWGNASFGQLGLGGIDEEIVLEPRKS--DFFINKRVRDVGCGLRHTVFVLDDGTVYTC 58

Query: 719  GDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRL 898
            G  D G+LGH  S  +++P Q+ AL  + +V +SCG  H+  +   G+++ +G    G+L
Sbjct: 59   GCNDLGQLGHEKS--RKKPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQL 116

Query: 899  GL-GNTSNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNST 1075
            GL G+    ++P  + +L   QI QVACG  H+LA+S   S V+ +G   YG+LGLG   
Sbjct: 117  GLVGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSK-ASEVFCWGQNKYGQLGLGTDC 175

Query: 1076 AK-SSPQKVDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGLPEGRARNHNRPQQ 1252
             K +SPQ +  L GI   +VA G   S  LT  G ++ +G+++   L      +   P  
Sbjct: 176  KKQTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNL 235

Query: 1253 IPVLAGVVIEDVAVGAEHTLALASTGDVYAWGSNSEGQLGLGHTNHVREPTLVTVLQGKN 1432
            +  L    I  +  G +HT AL   G V+ +G+   GQLG   T+H   P  V  L G  
Sbjct: 236  LKSLRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSI 295

Query: 1433 VRQISAGRCHSAAW 1474
            V +I+ GR H++A+
Sbjct: 296  VTEIACGRQHTSAF 309



 Score =  160 bits (406), Expect = 6e-39
 Identities = 98/307 (31%), Positives = 161/307 (52%), Gaps = 3/307 (0%)
 Frame = +2

Query: 500  CGQNCTFVIQANGTVLACGEGSYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSDGH 679
            CG   T  +  +GTV  CG    G+LG   S       V    Q  V      SCG + H
Sbjct: 41   CGLRHTVFVLDDGTVYTCGCNDLGQLGHEKSRKKPEQVVALDAQNIV----AVSCG-EAH 95

Query: 680  SMALTESGEVFSWGDGDYGKLG-HGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSD 856
            ++AL + G+V++WG    G+LG  G+ +  R PR I++L   ++VQ++CG+ HS  ++  
Sbjct: 96   TLALNDKGQVYAWGLDSDGQLGLVGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKA 155

Query: 857  GKLFTFGNGDYGRLGLGNTSNKKL-PERVTALEGYQIGQVACGLNHTLAVSADGSMVWAF 1033
             ++F +G   YG+LGLG    K+  P+ + +L G    QVA G  H+  ++  G+ ++ +
Sbjct: 156  SEVFCWGQNKYGQLGLGTDCKKQTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGA-IFGW 214

Query: 1034 GDGDYGKLGLGNSTAKSSPQKVDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGL 1213
            G   +G+LGL +   +  P  +  L    I  + CG   + ALTK+G V+TFG      L
Sbjct: 215  GRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQL 274

Query: 1214 PEGRARNHNRPQQIPVLAGVVIEDVAVGAEHTLA-LASTGDVYAWGSNSEGQLGLGHTNH 1390
                  +   P+++  L G ++ ++A G +HT A + S+G +Y++G    GQLG G T++
Sbjct: 275  GHNSTSHEINPRKVFELMGSIVTEIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSN 334

Query: 1391 VREPTLV 1411
             + P  V
Sbjct: 335  RKSPFTV 341



 Score =  147 bits (371), Expect = 7e-35
 Identities = 90/258 (34%), Positives = 136/258 (52%), Gaps = 4/258 (1%)
 Frame = +2

Query: 716  WGDGDYGKLGHGNSDRQ--RRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDY 889
            WG+  +G+LG G  D +    PR+ +    + V  + CG +H+  V  DG ++T G  D 
Sbjct: 4    WGNASFGQLGLGGIDEEIVLEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGCNDL 63

Query: 890  GRLGLGNTSNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGL-G 1066
            G+LG  +  ++K PE+V AL+   I  V+CG  HTLA++ D   V+A+G    G+LGL G
Sbjct: 64   GQLG--HEKSRKKPEQVVALDAQNIVAVSCGEAHTLALN-DKGQVYAWGLDSDGQLGLVG 120

Query: 1067 NSTAKSSPQKVDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGLPEGR-ARNHNR 1243
            +      P+ +  L  I I +VACG   S+AL+K   V+ +GQ++   L  G   +    
Sbjct: 121  SEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKKQTS 180

Query: 1244 PQQIPVLAGVVIEDVAVGAEHTLALASTGDVYAWGSNSEGQLGLGHTNHVREPTLVTVLQ 1423
            PQ +  L G+    VA G  H+  L  +G ++ WG N  GQLGL   N    P L+  L+
Sbjct: 181  PQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLR 240

Query: 1424 GKNVRQISAGRCHSAAWT 1477
             + +  I  G  H+AA T
Sbjct: 241  SQKIVYICCGEDHTAALT 258



 Score =  130 bits (326), Expect = 1e-29
 Identities = 74/242 (30%), Positives = 116/242 (47%), Gaps = 4/242 (1%)
 Frame = +2

Query: 377  LGGKCDVYLWGAGRHGQLAEAGRNVMVXXXXXXXXXXXX----VICGQNCTFVIQANGTV 544
            L  K  VY WG    GQL   G    +                V CG   +  +     V
Sbjct: 99   LNDKGQVYAWGLDSDGQLGLVGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEV 158

Query: 545  LACGEGSYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSDGHSMALTESGEVFSWGD 724
               G+  YG+LG G   D    T    L+  +    +       HS  LT SG +F WG 
Sbjct: 159  FCWGQNKYGQLGLGT--DCKKQTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGR 216

Query: 725  GDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLGL 904
              +G+LG  + + +  P  +++L+ +++V + CG  H+A +T +G +FTFG G YG+LG 
Sbjct: 217  NKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGH 276

Query: 905  GNTSNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNSTAKS 1084
             +TS++  P +V  L G  + ++ACG  HT A       +++FG G  G+LG G+++ + 
Sbjct: 277  NSTSHEINPRKVFELMGSIVTEIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRK 336

Query: 1085 SP 1090
            SP
Sbjct: 337  SP 338



 Score =  110 bits (275), Expect = 9e-24
 Identities = 68/225 (30%), Positives = 116/225 (51%), Gaps = 5/225 (2%)
 Frame = +2

Query: 272 VPEDELVFLMDNSKWINGMDEQIMSWATSRPEDWHLGGKCDVYLWGAGRHGQLAEA---- 439
           V  +E + +  N K ++  D QI+  A        L    +V+ WG  ++GQL       
Sbjct: 119 VGSEECIRVPRNIKSLS--DIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCK 176

Query: 440 GRNVMVXXXXXXXXXXXXVICGQNCTFVIQANGTVLACGEGSYGRLGQGNSDDLHVLTVI 619
            +                V  G   +FV+  +G +   G   +G+LG  + +D +V  ++
Sbjct: 177 KQTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLL 236

Query: 620 SALQGFVVTQLVTSCGSDGHSMALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQG 799
            +L+     ++V  C  + H+ ALT+ G VF++G G YG+LGH ++  +  PR++  L G
Sbjct: 237 KSLRS---QKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMG 293

Query: 800 EEVVQMSCGFKH-SAVVTSDGKLFTFGNGDYGRLGLGNTSNKKLP 931
             V +++CG +H SA V S G++++FG G  G+LG G+TSN+K P
Sbjct: 294 SIVTEIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRKSP 338



 Score = 73.9 bits (180), Expect = 9e-13
 Identities = 79/329 (24%), Positives = 139/329 (42%), Gaps = 5/329 (1%)
 Frame = +2

Query: 1937 KVKLVGEGADDAGGVFDDTITEMCQELETGIVDLLIPSPNATAEVGYNRDRFL-FNPSAC 2113
            KV  VGE A DAGGV  +    + +EL           P       Y   R + F+    
Sbjct: 731  KVIFVGEDAVDAGGVRKEFFLLIMRELL---------DPKYGMFRYYEDSRLIWFSDKTF 781

Query: 2114 LDEHLMQFKFLGILMGVAIRTKKPLDLHLAPLVWKQLCCVPXXXXXXXXXXXXYVQTLNS 2293
             D  L  F  +G++ G+AI     +DLH    ++K+L                  +++  
Sbjct: 782  EDSDL--FHLIGVICGLAIYNCTIVDLHFPLALYKKLLKKKPSLDDLKELMPDVGRSMQQ 839

Query: 2294 ILHIEDSGITEESF--HEMIPLDSFVGQSADGKMVPIIPGGNSIPLTFSNRKEYVERAIE 2467
            +L   +  I EE+F  +  I +++F       ++  ++  G    +   NR+E+V+  ++
Sbjct: 840  LLDYPEDDI-EETFCLNFTITVENFGAT----EVKELVLNGADTAVNKQNRQEFVDAYVD 894

Query: 2468 YRLHEMDRQVA-AVREGMSWIVPVPLLSLLTAKQLEQMVCGMPEISVEVLKKVVRYR-EV 2641
            Y  ++    +  A   G   +    +L L    +L+ MV G      + L+K   Y+ E 
Sbjct: 895  YIFNKSVASLFDAFHAGFHKVCGGKVLLLFQPNELQAMVIGNTNYDWKELEKNTEYKGEY 954

Query: 2642 DEQHQLVQWFWHTLEEFSNEERVLFMRFVSGRSRLPANTADISQRFQIMKVDRPYDSLPT 2821
              +H  ++ FW    E   E++  F+ F++G  R+P      S +  I       + LP 
Sbjct: 955  WAEHPTIKIFWEVFHELPLEKKKQFLLFLTGSDRIPI-LGMKSLKLVIQSTGGGEEYLPV 1013

Query: 2822 SQTCFFQLRLPPYSSQLVMAERLRYAINN 2908
            S TCF  L LP Y+ +  +  +L  AI++
Sbjct: 1014 SHTCFNLLDLPKYTEKETLRSKLIQAIDH 1042


>ref|NP_071362.1| probable E3 ubiquitin-protein ligase HERC4 isoform a [Homo sapiens].
          Length = 1057

 Score =  160 bits (406), Expect = 6e-39
 Identities = 104/314 (33%), Positives = 164/314 (52%), Gaps = 3/314 (0%)
 Frame = +2

Query: 542  VLACGEGSYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSD-GHSMALTESGEVFSW 718
            +L  G  S+G+LG G  D+  VL    +   F + + V   G    H++ + + G V++ 
Sbjct: 1    MLCWGNASFGQLGLGGIDEEIVLEPRKS--DFFINKRVRDVGCGLRHTVFVLDDGTVYTC 58

Query: 719  GDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRL 898
            G  D G+LGH  S  +++P Q+ AL  + +V +SCG  H+  +   G+++ +G    G+L
Sbjct: 59   GCNDLGQLGHEKS--RKKPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQL 116

Query: 899  GL-GNTSNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNST 1075
            GL G+    ++P  + +L   QI QVACG  H+LA+S   S V+ +G   YG+LGLG   
Sbjct: 117  GLVGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSK-ASEVFCWGQNKYGQLGLGTDC 175

Query: 1076 AK-SSPQKVDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGLPEGRARNHNRPQQ 1252
             K +SPQ +  L GI   +VA G   S  LT  G ++ +G+++   L      +   P  
Sbjct: 176  KKQTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNL 235

Query: 1253 IPVLAGVVIEDVAVGAEHTLALASTGDVYAWGSNSEGQLGLGHTNHVREPTLVTVLQGKN 1432
            +  L    I  +  G +HT AL   G V+ +G+   GQLG   T+H   P  V  L G  
Sbjct: 236  LKSLRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSI 295

Query: 1433 VRQISAGRCHSAAW 1474
            V +I+ GR H++A+
Sbjct: 296  VTEIACGRQHTSAF 309



 Score =  160 bits (406), Expect = 6e-39
 Identities = 98/307 (31%), Positives = 161/307 (52%), Gaps = 3/307 (0%)
 Frame = +2

Query: 500  CGQNCTFVIQANGTVLACGEGSYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSDGH 679
            CG   T  +  +GTV  CG    G+LG   S       V    Q  V      SCG + H
Sbjct: 41   CGLRHTVFVLDDGTVYTCGCNDLGQLGHEKSRKKPEQVVALDAQNIV----AVSCG-EAH 95

Query: 680  SMALTESGEVFSWGDGDYGKLG-HGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSD 856
            ++AL + G+V++WG    G+LG  G+ +  R PR I++L   ++VQ++CG+ HS  ++  
Sbjct: 96   TLALNDKGQVYAWGLDSDGQLGLVGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKA 155

Query: 857  GKLFTFGNGDYGRLGLGNTSNKKL-PERVTALEGYQIGQVACGLNHTLAVSADGSMVWAF 1033
             ++F +G   YG+LGLG    K+  P+ + +L G    QVA G  H+  ++  G+ ++ +
Sbjct: 156  SEVFCWGQNKYGQLGLGTDCKKQTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGA-IFGW 214

Query: 1034 GDGDYGKLGLGNSTAKSSPQKVDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGL 1213
            G   +G+LGL +   +  P  +  L    I  + CG   + ALTK+G V+TFG      L
Sbjct: 215  GRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQL 274

Query: 1214 PEGRARNHNRPQQIPVLAGVVIEDVAVGAEHTLA-LASTGDVYAWGSNSEGQLGLGHTNH 1390
                  +   P+++  L G ++ ++A G +HT A + S+G +Y++G    GQLG G T++
Sbjct: 275  GHNSTSHEINPRKVFELMGSIVTEIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSN 334

Query: 1391 VREPTLV 1411
             + P  V
Sbjct: 335  RKSPFTV 341



 Score =  147 bits (371), Expect = 7e-35
 Identities = 90/258 (34%), Positives = 136/258 (52%), Gaps = 4/258 (1%)
 Frame = +2

Query: 716  WGDGDYGKLGHGNSDRQ--RRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDY 889
            WG+  +G+LG G  D +    PR+ +    + V  + CG +H+  V  DG ++T G  D 
Sbjct: 4    WGNASFGQLGLGGIDEEIVLEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGCNDL 63

Query: 890  GRLGLGNTSNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGL-G 1066
            G+LG  +  ++K PE+V AL+   I  V+CG  HTLA++ D   V+A+G    G+LGL G
Sbjct: 64   GQLG--HEKSRKKPEQVVALDAQNIVAVSCGEAHTLALN-DKGQVYAWGLDSDGQLGLVG 120

Query: 1067 NSTAKSSPQKVDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGLPEGR-ARNHNR 1243
            +      P+ +  L  I I +VACG   S+AL+K   V+ +GQ++   L  G   +    
Sbjct: 121  SEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKKQTS 180

Query: 1244 PQQIPVLAGVVIEDVAVGAEHTLALASTGDVYAWGSNSEGQLGLGHTNHVREPTLVTVLQ 1423
            PQ +  L G+    VA G  H+  L  +G ++ WG N  GQLGL   N    P L+  L+
Sbjct: 181  PQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLR 240

Query: 1424 GKNVRQISAGRCHSAAWT 1477
             + +  I  G  H+AA T
Sbjct: 241  SQKIVYICCGEDHTAALT 258



 Score =  130 bits (326), Expect = 1e-29
 Identities = 74/242 (30%), Positives = 116/242 (47%), Gaps = 4/242 (1%)
 Frame = +2

Query: 377  LGGKCDVYLWGAGRHGQLAEAGRNVMVXXXXXXXXXXXX----VICGQNCTFVIQANGTV 544
            L  K  VY WG    GQL   G    +                V CG   +  +     V
Sbjct: 99   LNDKGQVYAWGLDSDGQLGLVGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEV 158

Query: 545  LACGEGSYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSDGHSMALTESGEVFSWGD 724
               G+  YG+LG G   D    T    L+  +    +       HS  LT SG +F WG 
Sbjct: 159  FCWGQNKYGQLGLGT--DCKKQTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGR 216

Query: 725  GDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLGL 904
              +G+LG  + + +  P  +++L+ +++V + CG  H+A +T +G +FTFG G YG+LG 
Sbjct: 217  NKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGH 276

Query: 905  GNTSNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNSTAKS 1084
             +TS++  P +V  L G  + ++ACG  HT A       +++FG G  G+LG G+++ + 
Sbjct: 277  NSTSHEINPRKVFELMGSIVTEIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRK 336

Query: 1085 SP 1090
            SP
Sbjct: 337  SP 338



 Score =  110 bits (275), Expect = 9e-24
 Identities = 68/225 (30%), Positives = 116/225 (51%), Gaps = 5/225 (2%)
 Frame = +2

Query: 272 VPEDELVFLMDNSKWINGMDEQIMSWATSRPEDWHLGGKCDVYLWGAGRHGQLAEA---- 439
           V  +E + +  N K ++  D QI+  A        L    +V+ WG  ++GQL       
Sbjct: 119 VGSEECIRVPRNIKSLS--DIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCK 176

Query: 440 GRNVMVXXXXXXXXXXXXVICGQNCTFVIQANGTVLACGEGSYGRLGQGNSDDLHVLTVI 619
            +                V  G   +FV+  +G +   G   +G+LG  + +D +V  ++
Sbjct: 177 KQTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLL 236

Query: 620 SALQGFVVTQLVTSCGSDGHSMALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQG 799
            +L+     ++V  C  + H+ ALT+ G VF++G G YG+LGH ++  +  PR++  L G
Sbjct: 237 KSLRS---QKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMG 293

Query: 800 EEVVQMSCGFKH-SAVVTSDGKLFTFGNGDYGRLGLGNTSNKKLP 931
             V +++CG +H SA V S G++++FG G  G+LG G+TSN+K P
Sbjct: 294 SIVTEIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRKSP 338



 Score = 73.9 bits (180), Expect = 9e-13
 Identities = 79/329 (24%), Positives = 139/329 (42%), Gaps = 5/329 (1%)
 Frame = +2

Query: 1937 KVKLVGEGADDAGGVFDDTITEMCQELETGIVDLLIPSPNATAEVGYNRDRFL-FNPSAC 2113
            KV  VGE A DAGGV  +    + +EL           P       Y   R + F+    
Sbjct: 739  KVIFVGEDAVDAGGVRKEFFLLIMRELL---------DPKYGMFRYYEDSRLIWFSDKTF 789

Query: 2114 LDEHLMQFKFLGILMGVAIRTKKPLDLHLAPLVWKQLCCVPXXXXXXXXXXXXYVQTLNS 2293
             D  L  F  +G++ G+AI     +DLH    ++K+L                  +++  
Sbjct: 790  EDSDL--FHLIGVICGLAIYNCTIVDLHFPLALYKKLLKKKPSLDDLKELMPDVGRSMQQ 847

Query: 2294 ILHIEDSGITEESF--HEMIPLDSFVGQSADGKMVPIIPGGNSIPLTFSNRKEYVERAIE 2467
            +L   +  I EE+F  +  I +++F       ++  ++  G    +   NR+E+V+  ++
Sbjct: 848  LLDYPEDDI-EETFCLNFTITVENFGAT----EVKELVLNGADTAVNKQNRQEFVDAYVD 902

Query: 2468 YRLHEMDRQVA-AVREGMSWIVPVPLLSLLTAKQLEQMVCGMPEISVEVLKKVVRYR-EV 2641
            Y  ++    +  A   G   +    +L L    +L+ MV G      + L+K   Y+ E 
Sbjct: 903  YIFNKSVASLFDAFHAGFHKVCGGKVLLLFQPNELQAMVIGNTNYDWKELEKNTEYKGEY 962

Query: 2642 DEQHQLVQWFWHTLEEFSNEERVLFMRFVSGRSRLPANTADISQRFQIMKVDRPYDSLPT 2821
              +H  ++ FW    E   E++  F+ F++G  R+P      S +  I       + LP 
Sbjct: 963  WAEHPTIKIFWEVFHELPLEKKKQFLLFLTGSDRIPI-LGMKSLKLVIQSTGGGEEYLPV 1021

Query: 2822 SQTCFFQLRLPPYSSQLVMAERLRYAINN 2908
            S TCF  L LP Y+ +  +  +L  AI++
Sbjct: 1022 SHTCFNLLDLPKYTEKETLRSKLIQAIDH 1050


>ref|NP_001259.1| RCC1 and BTB domain-containing protein 2 [Homo sapiens].
          Length = 551

 Score =  152 bits (385), Expect = 2e-36
 Identities = 98/289 (33%), Positives = 149/289 (51%), Gaps = 3/289 (1%)
 Frame = +2

Query: 533  NGTVLACGEGSYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSDGHSMALTESGEVF 712
            N  +   G    G LG G+         + +L G  +  L  S GS  H +  T  GEVF
Sbjct: 64   NDEIFVLGTNCCGCLGLGDVQSTIEPRRLDSLNGKKIACL--SYGSGPHIVLATTEGEVF 121

Query: 713  SWGDGDYGKLGHGNSDRQRRPRQIEA-LQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDY 889
            +WG   Y +LG+G ++    P  I   L  ++V++++CG  HS V+TSDG++F +G  + 
Sbjct: 122  TWGHNAYSQLGNGTTNHGLVPCHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWGYNNS 181

Query: 890  GRLGLGNTSNKKLPERVTA-LEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLG 1066
            G++G G+T N+ +P RVT  L+   +  +ACG    +AV  D   V+ +G    G+LGLG
Sbjct: 182  GQVGSGSTVNQPIPRRVTGCLQNKVVVTIACGQMCCMAV-VDTGEVYVWGYNGNGQLGLG 240

Query: 1067 NSTAKSSPQKVDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGLPEGRARNHNRP 1246
            NS  + +P +V  L GI +++VACG   ++ LT +G VY +G +    L  G   N + P
Sbjct: 241  NSGNQPTPCRVAALQGIRVQRVACGYAHTLVLTDEGQVYAWGANSYGQLGTGNKSNQSYP 300

Query: 1247 QQIPVLAGVVIEDVAVGAEHTLALAST-GDVYAWGSNSEGQLGLGHTNH 1390
              + V    +IE  A  + HT A  +  G VY WG      + L H  H
Sbjct: 301  TPVTVEKDRIIEIAACHSTHTSAAKTQGGHVYMWGQCRGQSVILPHLTH 349



 Score =  147 bits (372), Expect = 5e-35
 Identities = 94/276 (34%), Positives = 153/276 (55%), Gaps = 4/276 (1%)
 Frame = +2

Query: 665  GSDGHSMALTE-SGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGF-KHS 838
            GS G+ +  T  + E+F  G    G LG G+      PR++++L G+++  +S G   H 
Sbjct: 52   GSAGNEVLYTTVNDEIFVLGTNCCGCLGLGDVQSTIEPRRLDSLNGKKIACLSYGSGPHI 111

Query: 839  AVVTSDGKLFTFGNGDYGRLGLGNTSNKKLPERV-TALEGYQIGQVACGLNHTLAVSADG 1015
             + T++G++FT+G+  Y +LG G T++  +P  + T L   Q+ +VACG  H+L +++DG
Sbjct: 112  VLATTEGEVFTWGHNAYSQLGNGTTNHGLVPCHISTNLSNKQVIEVACGSYHSLVLTSDG 171

Query: 1016 SMVWAFGDGDYGKLGLGNSTAKSSPQKVD-VLCGIGIKKVACGTQFSVALTKDGHVYTFG 1192
              V+A+G  + G++G G++  +  P++V   L    +  +ACG    +A+   G VY +G
Sbjct: 172  E-VFAWGYNNSGQVGSGSTVNQPIPRRVTGCLQNKVVVTIACGQMCCMAVVDTGEVYVWG 230

Query: 1193 QDRLIGLPEGRARNHNRPQQIPVLAGVVIEDVAVGAEHTLALASTGDVYAWGSNSEGQLG 1372
             +    L  G + N   P ++  L G+ ++ VA G  HTL L   G VYAWG+NS GQLG
Sbjct: 231  YNGNGQLGLGNSGNQPTPCRVAALQGIRVQRVACGYAHTLVLTDEGQVYAWGANSYGQLG 290

Query: 1373 LGHTNHVREPTLVTVLQGKNVRQISAGRCHSAAWTA 1480
             G+ ++   PT VTV   +  R I    CHS   +A
Sbjct: 291  TGNKSNQSYPTPVTV---EKDRIIEIAACHSTHTSA 323



 Score =  115 bits (287), Expect = 4e-25
 Identities = 73/220 (33%), Positives = 113/220 (51%), Gaps = 5/220 (2%)
 Frame = +2

Query: 392  DVYLWGAGRHGQLAEAGRNV-MVXXXXXXXXXXXXVI---CGQNCTFVIQANGTVLACGE 559
            +V+ WG   + QL     N  +V            VI   CG   + V+ ++G V A G 
Sbjct: 119  EVFTWGHNAYSQLGNGTTNHGLVPCHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWGY 178

Query: 560  GSYGRLGQGNSDDLHV-LTVISALQGFVVTQLVTSCGSDGHSMALTESGEVFSWGDGDYG 736
             + G++G G++ +  +   V   LQ  VV  +  +CG     MA+ ++GEV+ WG    G
Sbjct: 179  NNSGQVGSGSTVNQPIPRRVTGCLQNKVVVTI--ACGQMC-CMAVVDTGEVYVWGYNGNG 235

Query: 737  KLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLGLGNTS 916
            +LG GNS  Q  P ++ ALQG  V +++CG+ H+ V+T +G+++ +G   YG+LG GN S
Sbjct: 236  QLGLGNSGNQPTPCRVAALQGIRVQRVACGYAHTLVLTDEGQVYAWGANSYGQLGTGNKS 295

Query: 917  NKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFG 1036
            N+  P  VT  +   I   AC   HT A    G  V+ +G
Sbjct: 296  NQSYPTPVTVEKDRIIEIAACHSTHTSAAKTQGGHVYMWG 335


>ref|NP_000319.1| X-linked retinitis pigmentosa GTPase regulator isoform A [Homo
            sapiens].
          Length = 815

 Score =  149 bits (376), Expect = 2e-35
 Identities = 104/334 (31%), Positives = 171/334 (51%), Gaps = 6/334 (1%)
 Frame = +2

Query: 500  CGQNCTFVIQANGTVLACGEGSYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSDGH 679
            CG   + V+  N  +   G  ++G+LG G+   +   T + AL+   V   + +CG + H
Sbjct: 42   CGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVK--LAACGRN-H 98

Query: 680  SMALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGE-EVVQMSCGFKHSAVVTSD 856
            ++  TE G V++ G  + G+LG G+++ +     I     E ++ Q+S G   SA +T D
Sbjct: 99   TLVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTED 158

Query: 857  GKLFTFGNGDYGRLGLGNTSNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFG 1036
            G+LF +G+   G++GL N SN  +P++VT   G  +  ++CG  H+  V+ DG + + FG
Sbjct: 159  GRLFMWGDNSEGQIGLKNVSNVCVPQQVTI--GKPVSWISCGYYHSAFVTTDGEL-YVFG 215

Query: 1037 DGDYGKLGLGNSTAKS--SPQKVDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIG 1210
            + + GKLGL N    +  +PQ V  +    I+ VACG + +V LT++  VYTFG  +   
Sbjct: 216  EPENGKLGLPNQLLGNHRTPQLVSEIPEKVIQ-VACGGEHTVVLTENA-VYTFGLGQFGQ 273

Query: 1211 LPEGRAR-NHNRPQQIPVLAGVVIEDVAVGAEHTLALASTGDVYAWGSNSEGQLGLGHTN 1387
            L  G      + P+ I  +    I  ++ G  HT  +   G +Y +G    G+LGLG  N
Sbjct: 274  LGLGTFLFETSEPKVIENIRDQTISYISCGENHTALITDIGLMYTFGDGRHGKLGLGLEN 333

Query: 1388 HVRE--PTLVTVLQGKNVRQISAGRCHSAAWTAP 1483
                  PTL +      V+ ++ G CH   + AP
Sbjct: 334  FTNHFIPTLCSNFLRFIVKLVACGGCHMVVFAAP 367



 Score =  143 bits (360), Expect = 1e-33
 Identities = 104/323 (32%), Positives = 164/323 (50%), Gaps = 9/323 (2%)
 Frame = +2

Query: 383  GKCDVYLWGAGRHGQLAEAGRNVMVXXXXXXXXXXXXV---ICGQNCTFVIQANGTVLAC 553
            G   +Y++G+   GQL    ++ +             V    CG+N T V    G V A 
Sbjct: 52   GNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHTLVSTEGGNVYAT 111

Query: 554  GEGSYGRLGQGNSDDLHVLTVISALQG-FVVTQLVTSCGSDGHSMALTESGEVFSWGDGD 730
            G  + G+LG G++++ +   VIS       + QL  S GS+  S ALTE G +F WGD  
Sbjct: 112  GGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQL--SAGSN-TSAALTEDGRLFMWGDNS 168

Query: 731  YGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLGLGN 910
             G++G  N      P+Q+    G+ V  +SCG+ HSA VT+DG+L+ FG  + G+LGL N
Sbjct: 169  EGQIGLKNVSNVCVPQQVTI--GKPVSWISCGYYHSAFVTTDGELYVFGEPENGKLGLPN 226

Query: 911  --TSNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNSTAKS 1084
                N + P+ V+ +   ++ QVACG  HT+ ++ +   V+ FG G +G+LGLG    ++
Sbjct: 227  QLLGNHRTPQLVSEIP-EKVIQVACGGEHTVVLTENA--VYTFGLGQFGQLGLGTFLFET 283

Query: 1085 S-PQKVDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDR--LIGLPEGRARNHNRPQQI 1255
            S P+ ++ +    I  ++CG   +  +T  G +YTFG  R   +GL      NH  P   
Sbjct: 284  SEPKVIENIRDQTISYISCGENHTALITDIGLMYTFGDGRHGKLGLGLENFTNHFIPTLC 343

Query: 1256 PVLAGVVIEDVAVGAEHTLALAS 1324
                  +++ VA G  H +  A+
Sbjct: 344  SNFLRFIVKLVACGGCHMVVFAA 366



 Score =  140 bits (353), Expect = 8e-33
 Identities = 89/277 (32%), Positives = 149/277 (53%), Gaps = 4/277 (1%)
 Frame = +2

Query: 659  SCGSDGHSMALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHS 838
            SCG D HS  +T + +++ +G  ++G+LG G+     +P  ++AL+ E+V   +CG  H+
Sbjct: 41   SCG-DEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHT 99

Query: 839  AVVTSDGKLFTFGNGDYGRLGLGNTSNKKLPERVTALEG-YQIGQVACGLNHTLAVSADG 1015
             V T  G ++  G  + G+LGLG+T  +     ++     ++I Q++ G N + A++ DG
Sbjct: 100  LVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDG 159

Query: 1016 SMVWAFGDGDYGKLGLGNSTAKSSPQKVDVLCGIGIKKVACGTQFSVALTKDGHVYTFG- 1192
             + + +GD   G++GL N +    PQ+V +  G  +  ++CG   S  +T DG +Y FG 
Sbjct: 160  RL-FMWGDNSEGQIGLKNVSNVCVPQQVTI--GKPVSWISCGYYHSAFVTTDGELYVFGE 216

Query: 1193 -QDRLIGLPEGRARNHNRPQQIPVLAGVVIEDVAVGAEHTLALASTGDVYAWGSNSEGQL 1369
             ++  +GLP     NH  PQ +  +   VI+ VA G EHT+ L     VY +G    GQL
Sbjct: 217  PENGKLGLPNQLLGNHRTPQLVSEIPEKVIQ-VACGGEHTVVLTENA-VYTFGLGQFGQL 274

Query: 1370 GLG-HTNHVREPTLVTVLQGKNVRQISAGRCHSAAWT 1477
            GLG       EP ++  ++ + +  IS G  H+A  T
Sbjct: 275  GLGTFLFETSEPKVIENIRDQTISYISCGENHTALIT 311


>ref|NP_001030025.1| X-linked retinitis pigmentosa GTPase regulator isoform C [Homo
            sapiens].
          Length = 1152

 Score =  149 bits (376), Expect = 2e-35
 Identities = 104/334 (31%), Positives = 171/334 (51%), Gaps = 6/334 (1%)
 Frame = +2

Query: 500  CGQNCTFVIQANGTVLACGEGSYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSDGH 679
            CG   + V+  N  +   G  ++G+LG G+   +   T + AL+   V   + +CG + H
Sbjct: 42   CGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVK--LAACGRN-H 98

Query: 680  SMALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGE-EVVQMSCGFKHSAVVTSD 856
            ++  TE G V++ G  + G+LG G+++ +     I     E ++ Q+S G   SA +T D
Sbjct: 99   TLVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTED 158

Query: 857  GKLFTFGNGDYGRLGLGNTSNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFG 1036
            G+LF +G+   G++GL N SN  +P++VT   G  +  ++CG  H+  V+ DG + + FG
Sbjct: 159  GRLFMWGDNSEGQIGLKNVSNVCVPQQVTI--GKPVSWISCGYYHSAFVTTDGEL-YVFG 215

Query: 1037 DGDYGKLGLGNSTAKS--SPQKVDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIG 1210
            + + GKLGL N    +  +PQ V  +    I+ VACG + +V LT++  VYTFG  +   
Sbjct: 216  EPENGKLGLPNQLLGNHRTPQLVSEIPEKVIQ-VACGGEHTVVLTENA-VYTFGLGQFGQ 273

Query: 1211 LPEGRAR-NHNRPQQIPVLAGVVIEDVAVGAEHTLALASTGDVYAWGSNSEGQLGLGHTN 1387
            L  G      + P+ I  +    I  ++ G  HT  +   G +Y +G    G+LGLG  N
Sbjct: 274  LGLGTFLFETSEPKVIENIRDQTISYISCGENHTALITDIGLMYTFGDGRHGKLGLGLEN 333

Query: 1388 HVRE--PTLVTVLQGKNVRQISAGRCHSAAWTAP 1483
                  PTL +      V+ ++ G CH   + AP
Sbjct: 334  FTNHFIPTLCSNFLRFIVKLVACGGCHMVVFAAP 367



 Score =  143 bits (360), Expect = 1e-33
 Identities = 104/323 (32%), Positives = 164/323 (50%), Gaps = 9/323 (2%)
 Frame = +2

Query: 383  GKCDVYLWGAGRHGQLAEAGRNVMVXXXXXXXXXXXXV---ICGQNCTFVIQANGTVLAC 553
            G   +Y++G+   GQL    ++ +             V    CG+N T V    G V A 
Sbjct: 52   GNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHTLVSTEGGNVYAT 111

Query: 554  GEGSYGRLGQGNSDDLHVLTVISALQG-FVVTQLVTSCGSDGHSMALTESGEVFSWGDGD 730
            G  + G+LG G++++ +   VIS       + QL  S GS+  S ALTE G +F WGD  
Sbjct: 112  GGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQL--SAGSN-TSAALTEDGRLFMWGDNS 168

Query: 731  YGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLGLGN 910
             G++G  N      P+Q+    G+ V  +SCG+ HSA VT+DG+L+ FG  + G+LGL N
Sbjct: 169  EGQIGLKNVSNVCVPQQVTI--GKPVSWISCGYYHSAFVTTDGELYVFGEPENGKLGLPN 226

Query: 911  --TSNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNSTAKS 1084
                N + P+ V+ +   ++ QVACG  HT+ ++ +   V+ FG G +G+LGLG    ++
Sbjct: 227  QLLGNHRTPQLVSEIP-EKVIQVACGGEHTVVLTENA--VYTFGLGQFGQLGLGTFLFET 283

Query: 1085 S-PQKVDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDR--LIGLPEGRARNHNRPQQI 1255
            S P+ ++ +    I  ++CG   +  +T  G +YTFG  R   +GL      NH  P   
Sbjct: 284  SEPKVIENIRDQTISYISCGENHTALITDIGLMYTFGDGRHGKLGLGLENFTNHFIPTLC 343

Query: 1256 PVLAGVVIEDVAVGAEHTLALAS 1324
                  +++ VA G  H +  A+
Sbjct: 344  SNFLRFIVKLVACGGCHMVVFAA 366



 Score =  140 bits (353), Expect = 8e-33
 Identities = 89/277 (32%), Positives = 149/277 (53%), Gaps = 4/277 (1%)
 Frame = +2

Query: 659  SCGSDGHSMALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHS 838
            SCG D HS  +T + +++ +G  ++G+LG G+     +P  ++AL+ E+V   +CG  H+
Sbjct: 41   SCG-DEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHT 99

Query: 839  AVVTSDGKLFTFGNGDYGRLGLGNTSNKKLPERVTALEG-YQIGQVACGLNHTLAVSADG 1015
             V T  G ++  G  + G+LGLG+T  +     ++     ++I Q++ G N + A++ DG
Sbjct: 100  LVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDG 159

Query: 1016 SMVWAFGDGDYGKLGLGNSTAKSSPQKVDVLCGIGIKKVACGTQFSVALTKDGHVYTFG- 1192
             + + +GD   G++GL N +    PQ+V +  G  +  ++CG   S  +T DG +Y FG 
Sbjct: 160  RL-FMWGDNSEGQIGLKNVSNVCVPQQVTI--GKPVSWISCGYYHSAFVTTDGELYVFGE 216

Query: 1193 -QDRLIGLPEGRARNHNRPQQIPVLAGVVIEDVAVGAEHTLALASTGDVYAWGSNSEGQL 1369
             ++  +GLP     NH  PQ +  +   VI+ VA G EHT+ L     VY +G    GQL
Sbjct: 217  PENGKLGLPNQLLGNHRTPQLVSEIPEKVIQ-VACGGEHTVVLTENA-VYTFGLGQFGQL 274

Query: 1370 GLG-HTNHVREPTLVTVLQGKNVRQISAGRCHSAAWT 1477
            GLG       EP ++  ++ + +  IS G  H+A  T
Sbjct: 275  GLGTFLFETSEPKVIENIRDQTISYISCGENHTALIT 311


>ref|NP_001158608.1| probable E3 ubiquitin-protein ligase HERC6 isoform 2 [Homo sapiens].
          Length = 986

 Score =  142 bits (359), Expect = 2e-33
 Identities = 96/281 (34%), Positives = 146/281 (51%), Gaps = 5/281 (1%)
 Frame = +2

Query: 647  QLVTSCGSDGHSMALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCG 826
            +L+ +   + HS+ L  +  V S GD   G+LG   + R   P  I+AL+   V  +SCG
Sbjct: 24   ELLQAASGERHSLLLLTNHRVLSCGDNSRGQLGRRGAQRGELPEPIQALETLIVDLVSCG 83

Query: 827  FKHSAVVTSDGKLFTFGNGDYGRLGLGNTSNKKL-PERVTALEGYQIGQVACGLNHTLAV 1003
             +HS  V   G++F +G G  G+LG+G        P+++  L   +I QV+CG  H+LA+
Sbjct: 84   KEHSLAVCHKGRVFAWGAGSEGQLGIGEFKEISFTPKKIMTLNDIKIIQVSCGHYHSLAL 143

Query: 1004 SADGSMVWAFGDGDYGKLGLGNS-TAKSSPQKVDVLCGIGIKKVACGTQFSVALTKDGHV 1180
            S D S V+++G   +G+LGLG    +++SPQ+V  L GI + +VA G   S AL+  G  
Sbjct: 144  SKD-SQVFSWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLCGTS 202

Query: 1181 YTFGQDRLIGLP-EGR--ARNHNRPQQIPVLAGVVIEDVAVGAEHTLALASTGDVYAWGS 1351
            + +G +    L   GR      N+P  +  L  + +  ++ G  HT  L   G V+ +G 
Sbjct: 203  FGWGSNSAGQLALSGRNVPVQSNKPLSVGALKNLGVVYISCGDAHTAVLTQDGKVFTFGD 262

Query: 1352 NSEGQLGLGHTNHVREPTLVTVLQGKNVRQISAGRCHSAAW 1474
            N  GQLG   T   R P LV  + G  V QI  G  H+ A+
Sbjct: 263  NRSGQLGYSPTPEKRGPQLVERIDGL-VSQIDCGSYHTLAY 302



 Score =  130 bits (327), Expect = 8e-30
 Identities = 84/248 (33%), Positives = 133/248 (53%), Gaps = 5/248 (2%)
 Frame = +2

Query: 749  GNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLGLGNTSNKKL 928
            G   R+ + R+     G E++Q + G +HS ++ ++ ++ + G+   G+LG       +L
Sbjct: 6    GADSRELQRRRTAGSPGAELLQAASGERHSLLLLTNHRVLSCGDNSRGQLGRRGAQRGEL 65

Query: 929  PERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNSTAKS-SPQKVDV 1105
            PE + ALE   +  V+CG  H+LAV   G  V+A+G G  G+LG+G     S +P+K+  
Sbjct: 66   PEPIQALETLIVDLVSCGKEHSLAVCHKG-RVFAWGAGSEGQLGIGEFKEISFTPKKIMT 124

Query: 1106 LCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGLPEGRA-RNHNRPQQIPVLAGVVIE 1282
            L  I I +V+CG   S+AL+KD  V+++G++    L  G+   +   PQ++  L G+ + 
Sbjct: 125  LNDIKIIQVSCGHYHSLALSKDSQVFSWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLA 184

Query: 1283 DVAVGAEHTLALASTGDVYAWGSNSEGQLGLGHTN---HVREPTLVTVLQGKNVRQISAG 1453
             VA G  H+ AL+  G  + WGSNS GQL L   N      +P  V  L+   V  IS G
Sbjct: 185  QVAAGGAHSFALSLCGTSFGWGSNSAGQLALSGRNVPVQSNKPLSVGALKNLGVVYISCG 244

Query: 1454 RCHSAAWT 1477
              H+A  T
Sbjct: 245  DAHTAVLT 252



 Score =  103 bits (258), Expect = 8e-22
 Identities = 70/224 (31%), Positives = 105/224 (46%), Gaps = 8/224 (3%)
 Frame = +2

Query: 395  VYLWGAGRHGQLAEAG-RNVMVXXXXXXXXXXXXVI---CGQNCTFVIQANGTVLACGEG 562
            V+ WGAG  GQL     + +              +I   CG   +  +  +  V + G+ 
Sbjct: 96   VFAWGAGSEGQLGIGEFKEISFTPKKIMTLNDIKIIQVSCGHYHSLALSKDSQVFSWGKN 155

Query: 563  SYGRLGQGNSDDLHVLTV-ISALQGFVVTQLVTSCGSDGHSMALTESGEVFSWGDGDYGK 739
            S+G+LG G           + +L+G  + Q+        HS AL+  G  F WG    G+
Sbjct: 156  SHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAG---GAHSFALSLCGTSFGWGSNSAGQ 212

Query: 740  L---GHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLGLGN 910
            L   G     +  +P  + AL+   VV +SCG  H+AV+T DGK+FTFG+   G+LG   
Sbjct: 213  LALSGRNVPVQSNKPLSVGALKNLGVVYISCGDAHTAVLTQDGKVFTFGDNRSGQLGYSP 272

Query: 911  TSNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDG 1042
            T  K+ P+ V  ++G  + Q+ CG  HTLA       V +FG G
Sbjct: 273  TPEKRGPQLVERIDGL-VSQIDCGSYHTLAYVHTTGQVVSFGHG 315



 Score = 68.2 bits (165), Expect = 5e-11
 Identities = 50/183 (27%), Positives = 87/183 (47%), Gaps = 4/183 (2%)
 Frame = +2

Query: 2378 DGKMVPIIPGGNSIPLTFSNRKEYVERAIEYRLHEMDRQV-AAVREGMSWIVPVPLLSLL 2554
            D   V +IP G SIP+  +N+++YV + I+Y  +   + V    + G   +    +L   
Sbjct: 796  DQNDVDLIPNGISIPVDQTNKRDYVSKYIDYIFNVSVKAVYEEFQRGFYRVCEKEILRHF 855

Query: 2555 TAKQLEQMVCGMPEISVEVLKKVVRYRE-VDEQHQLVQWFWHTLEEFSNEERVLFMRFVS 2731
              ++L   + G  +   +  ++  +Y +   + H  +Q FW    + + +E+  F+ F++
Sbjct: 856  YPEELMTAIIGNTDYDWKQFEQNSKYEQGYQKSHPTIQLFWKAFHKLTLDEKKKFLFFLT 915

Query: 2732 GRSRLPANTADISQRFQIMKVDRPYDSL--PTSQTCFFQLRLPPYSSQLVMAERLRYAIN 2905
            GR RL A    I +   + +    +     PTS TC   L LP YS+   M E L+ AIN
Sbjct: 916  GRDRLHAR--GIQKMEIVFRCPETFSERDHPTSITCHNILSLPKYSTMERMEEALQVAIN 973

Query: 2906 NCR 2914
            N R
Sbjct: 974  NNR 976


  Database: RefSeq49_HP.fasta
    Posted date:  Oct 17, 2011  1:42 PM
  Number of letters in database: 18,297,164
  Number of sequences in database:  32,964
  
Lambda     K      H
   0.318    0.134    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 32964
Number of Hits to DB: 138,187,711
Number of extensions: 3671798
Number of successful extensions: 13045
Number of sequences better than 1.0e-05: 67
Number of HSP's gapped: 12307
Number of HSP's successfully gapped: 170
Length of query: 1168
Length of database: 18,297,164
Length adjustment: 114
Effective length of query: 1054
Effective length of database: 14,539,268
Effective search space: 15324388472
Effective search space used: 15324388472
Neighboring words threshold: 12
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 36 (18.5 bits)

BLASTX 2.2.24 [Aug-08-2010]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= 20110601C-003115
         (3506 letters)

Database: RefSeq49_MP.fasta 
           30,036 sequences; 15,617,559 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

Alignment   gi|NP_663592.3| hect domain and RCC1-like domain 1 [Mus musculu...  1962   0.0  
Alignment   gi|NP_034548.2| E3 ubiquitin-protein ligase HERC2 [Mus musculus].    646   0.0  
Alignment   gi|NP_780453.1| E3 ubiquitin-protein ligase HECTD3 [Mus musculu...   192   2e-48
Alignment   gi|NP_082981.3| hect domain and RLD 3 [Mus musculus].                179   1e-44
Alignment   gi|NP_084390.1| probable E3 ubiquitin-protein ligase HERC4 isof...   162   2e-39
Alignment   gi|NP_080377.2| probable E3 ubiquitin-protein ligase HERC4 isof...   162   2e-39
Alignment   gi|NP_080268.1| hect domain and RLD 5 [Mus musculus].                153   8e-37
Alignment   gi|NP_001164165.1| RCC1 and BTB domain-containing protein 2 [Mu...   152   1e-36
Alignment   gi|NP_598844.3| RCC1 and BTB domain-containing protein 2 [Mus m...   152   1e-36
Alignment   gi|NP_082040.2| RCC1 and BTB domain-containing protein 1 [Mus m...   145   2e-34

>ref|NP_663592.3| hect domain and RCC1-like domain 1 [Mus musculus].
          Length = 4859

 Score = 1962 bits (5083), Expect = 0.0
 Identities = 961/994 (96%), Positives = 964/994 (96%)
 Frame = +2

Query: 2    EKPHVVCGDQLVHSPYMQCLASLAVGLHLDQLLCNPPVPPHHQNCLPDPASWNPNEWAWL 181
            EKPHVVCGDQLVHSPYMQCLASLAVGLHLDQLLCNPPVPPHHQNCLPDP SWNPNEWAWL
Sbjct: 3866 EKPHVVCGDQLVHSPYMQCLASLAVGLHLDQLLCNPPVPPHHQNCLPDPTSWNPNEWAWL 3925

Query: 182  ECFSTTIKAAEALTNGAQFPESFSVPDLEPVPEDELVFLMDNSKWINGMDEQIMSWATSR 361
            ECFSTTIKAAEALTNGAQFPESF+VPDLEPVPEDELV LMDNSKWINGMDEQIMSWATSR
Sbjct: 3926 ECFSTTIKAAEALTNGAQFPESFTVPDLEPVPEDELVLLMDNSKWINGMDEQIMSWATSR 3985

Query: 362  PEDWHLGGKCDVYLWGAGRHGQLAEAGRNVMVXXXXXXXXXXXXVICGQNCTFVIQANGT 541
            PEDWHLGGKCDVYLWGAGRHGQLAEAGRNVMV            VICGQNCTFVIQANGT
Sbjct: 3986 PEDWHLGGKCDVYLWGAGRHGQLAEAGRNVMVPATAPSFSQAQQVICGQNCTFVIQANGT 4045

Query: 542  VLACGEGSYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSDGHSMALTESGEVFSWG 721
            VLACGEGSYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSDGHSMALTESGEVFSWG
Sbjct: 4046 VLACGEGSYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSDGHSMALTESGEVFSWG 4105

Query: 722  DGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLG 901
            DGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLG
Sbjct: 4106 DGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLG 4165

Query: 902  LGNTSNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNSTAK 1081
            LGNTSNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNSTAK
Sbjct: 4166 LGNTSNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNSTAK 4225

Query: 1082 SSPQKVDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGLPEGRARNHNRPQQIPV 1261
            SSPQKVDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGLPEGRARNHNRPQQIPV
Sbjct: 4226 SSPQKVDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGLPEGRARNHNRPQQIPV 4285

Query: 1262 LAGVVIEDVAVGAEHTLALASTGDVYAWGSNSEGQLGLGHTNHVREPTLVTVLQGKNVRQ 1441
            LAGVVIEDVAVGAEHTLALASTGDVYAWGSNSEGQLGLGHTNHVREPTLVTVLQGKN+RQ
Sbjct: 4286 LAGVVIEDVAVGAEHTLALASTGDVYAWGSNSEGQLGLGHTNHVREPTLVTVLQGKNIRQ 4345

Query: 1442 ISAGRCHSAAWTAPPVPPRAPGVSVPLQLGLPDAVPPQYGALREVSIHTARARLRLLYHF 1621
            ISAGRCHSAAWTAPPVPPRAPGVSVPLQLGLPDAVPPQYGALREVSIHT RARLRLLYHF
Sbjct: 4346 ISAGRCHSAAWTAPPVPPRAPGVSVPLQLGLPDAVPPQYGALREVSIHTVRARLRLLYHF 4405

Query: 1622 SDLMYSSWRLLNLSPNNQNSTSHYNAGTWGIVQGQLRPLLAPRVYTLPMVRSIGKTMVQG 1801
            SDLMYSSWRLLNLSPNNQNSTSHYNAGTWGIVQGQLRPLLAPRVYTLPMVRSIGKTMVQG
Sbjct: 4406 SDLMYSSWRLLNLSPNNQNSTSHYNAGTWGIVQGQLRPLLAPRVYTLPMVRSIGKTMVQG 4465

Query: 1802 KNYGPQITVKRISTRGRKCKPIFVQIARQVVKLNASDLRLPSRAWKVKLVGEGADDAGGV 1981
            KNYGPQITVKRISTRGRKCKPIFVQIARQVVKLNASDLRLPSRAWKVKLVGEGADDAGGV
Sbjct: 4466 KNYGPQITVKRISTRGRKCKPIFVQIARQVVKLNASDLRLPSRAWKVKLVGEGADDAGGV 4525

Query: 1982 FDDTITEMCQELETGIVDLLIPSPNATAEVGYNRDRFLFNPSACLDEHLMQFKFLGILMG 2161
            FDDTITEMCQELETGIVDLLIPSPNATAEVGYNRDRFLFNPSACLDEHLMQFKFLGILMG
Sbjct: 4526 FDDTITEMCQELETGIVDLLIPSPNATAEVGYNRDRFLFNPSACLDEHLMQFKFLGILMG 4585

Query: 2162 VAIRTKKPLDLHLAPLVWKQLCCVPXXXXXXXXXXXXYVQTLNSILHIEDSGITEESFHE 2341
            VAIRTKKPLDLHLAPLVWKQLCCVP            YVQTLNSILHIEDSGITEESFHE
Sbjct: 4586 VAIRTKKPLDLHLAPLVWKQLCCVPLTLEDLEEVDLLYVQTLNSILHIEDSGITEESFHE 4645

Query: 2342 MIPLDSFVGQSADGKMVPIIPGGNSIPLTFSNRKEYVERAIEYRLHEMDRQVAAVREGMS 2521
            MIPLDSFVGQSADGKMVPIIPGGNSIPLTFSNRKEYVERAIEYRLHEMDRQVAAVREGMS
Sbjct: 4646 MIPLDSFVGQSADGKMVPIIPGGNSIPLTFSNRKEYVERAIEYRLHEMDRQVAAVREGMS 4705

Query: 2522 WIVPVPLLSLLTAKQLEQMVCGMPEISVEVLKKVVRYREVDEQHQLVQWFWHTLEEFSNE 2701
            WIVPVPLLSLLTAKQLEQMVCGMPEI V+VLKKVVRYREVDEQHQLVQW W TLEEFSNE
Sbjct: 4706 WIVPVPLLSLLTAKQLEQMVCGMPEICVDVLKKVVRYREVDEQHQLVQWLWRTLEEFSNE 4765

Query: 2702 ERVLFMRFVSGRSRLPANTADISQRFQIMKVDRPYDSLPTSQTCFFQLRLPPYSSQLVMA 2881
            ERVLFMRFVSGRSRLPANTADISQRFQIMKVDRPYDSLPTSQTCFFQLRLPPYSSQLVMA
Sbjct: 4766 ERVLFMRFVSGRSRLPANTADISQRFQIMKVDRPYDSLPTSQTCFFQLRLPPYSSQLVMA 4825

Query: 2882 ERLRYAINNCRSIDMDNYMLSRNVDNAEGSDTDY 2983
            ERLRYAINNCRSIDMDNYMLSRNVDNAEGSDTDY
Sbjct: 4826 ERLRYAINNCRSIDMDNYMLSRNVDNAEGSDTDY 4859



 Score =  313 bits (802), Expect = 6e-85
 Identities = 165/369 (44%), Positives = 235/369 (63%), Gaps = 3/369 (0%)
 Frame = +2

Query: 389  CDVYLWGAGRHGQLAEAGRNVMVXXXXXXXXXXXXVI-CGQNCTFVIQANGTVLACGEGS 565
            C+VY+WG+    QL E  +  ++             I  GQ CTFVI  +G+V ACG+GS
Sbjct: 372  CEVYVWGSNSSHQLVEGTQEKILQPKLAPSFSDAQTIEAGQYCTFVISTDGSVRACGKGS 431

Query: 566  YGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSDGHSMALTESGEVFSWGDGDYGKLG 745
            YGRLG G+S++   L  ++      + ++ +S GSDGH++A T  GEVFSWGDGDYGKLG
Sbjct: 432  YGRLGLGDSNNQSTLKKLTFEPHRSIKKVSSSKGSDGHTLAFTTEGEVFSWGDGDYGKLG 491

Query: 746  HGNSDRQRRPRQIEA-LQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLGLGNTSNK 922
            HGNS  Q+ P+ I+  LQG+ VV +S G++HSA VT DG+L+T+G GD+GRLG G+++++
Sbjct: 492  HGNSSTQKYPKLIQGPLQGKVVVCVSAGYRHSAAVTEDGELYTWGEGDFGRLGHGDSNSR 551

Query: 923  KLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNSTAKSSPQKVD 1102
             +P  V  +    +G+V+CG +HT+A+S DG  VW+FG GD GKLG G++     P+ ++
Sbjct: 552  NIPTLVKDIS--NVGEVSCGSSHTIALSKDGRTVWSFGGGDNGKLGHGDTNRVYKPKVIE 609

Query: 1103 VLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGLPEGRARNHNRPQQIPVLAGVVIE 1282
             L G+ I+KV  G+Q S+ALT  G VY +G    +G     A    RP+ I  LA   I 
Sbjct: 610  ALQGMFIRKVCAGSQSSLALTSTGQVYAWGCGACLGCGSSEA-TALRPKLIEELAATRIV 668

Query: 1283 DVAVGAEHTLALASTGDVYAWGSNSEGQLGLGH-TNHVREPTLVTVLQGKNVRQISAGRC 1459
            D+++G  H L+L+   +VYAWG+NS GQ G G+ T  + +P  V+ L G  ++QISAG  
Sbjct: 669  DISIGDSHCLSLSHDNEVYAWGNNSMGQCGQGNSTGPITKPKKVSGLDGIAIQQISAGTS 728

Query: 1460 HSAAWTAPP 1486
            HS AWTA P
Sbjct: 729  HSLAWTALP 737


>ref|NP_034548.2| E3 ubiquitin-protein ligase HERC2 [Mus musculus].
          Length = 4836

 Score =  646 bits (1666), Expect = 0.0
 Identities = 390/1007 (38%), Positives = 544/1007 (54%), Gaps = 29/1007 (2%)
 Frame = +2

Query: 2    EKPHVVCGDQLVHSPYMQCLASLAVGLHLDQLLCNPPVPPHHQNCLPDPASWNPNEWAWL 181
            E P V  G QL+HSP+ + L +LA  L LD L C          C         ++WAW 
Sbjct: 3833 EDPIVRGGKQLLHSPFFKVLVALACDLELDTLPC----------CA------ETHKWAWF 3876

Query: 182  ECFSTTIKAAEALTNGAQFPESF------SVPDLEPVPEDELVFLMDNSKWINGMDEQIM 343
              +    + A AL      P  F       + +L    E   V    +S +    DEQ++
Sbjct: 3877 RRYCMASRVAVALDKRTPLPRLFLDEVAKKIRELMADSESMDVLHESHSIFKREQDEQLV 3936

Query: 344  SWATSRPEDWHL--GGKCDVYLWGAGRHGQLAEA-GRNVMVXXXXXXXXXXXXV--ICGQ 508
             W   RP+DW L  GG   +Y WG    GQL    G  V V            V  I G+
Sbjct: 3937 QWMNRRPDDWTLSAGGSGTIYGWGHNHRGQLGGIEGAKVKVPTPCEALATLRPVQLIGGE 3996

Query: 509  NCTFVIQANGTVLACGEGSYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSDGHSMA 688
               F + A+G + A G G+ GRLG G ++ +   T++ ++Q   + ++  + G   H +A
Sbjct: 3997 QTLFAVTADGKLYATGYGAGGRLGIGGTESVSTPTLLESIQHVFIKKVAVNSGGK-HCLA 4055

Query: 689  LTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLF 868
            L+  GEV+SWG+ + GKLGHGN     RPR IE+L+G EVV ++ G  HSA VT+ G L+
Sbjct: 4056 LSSEGEVYSWGEAEDGKLGHGNRSPCDRPRVIESLRGIEVVDVAAGGAHSACVTAAGDLY 4115

Query: 869  TFGNGDYGRLGLGNTSNKKLPERVTALEGYQIGQVACGLN--HTLAVSADGSMVWAFGDG 1042
            T+G G YGRLG  ++ ++  P+ V AL+G+++  +ACG     TL ++ D + VW++GDG
Sbjct: 4116 TWGKGRYGRLGHSDSEDQLKPKLVEALQGHRVIDIACGSGDAQTLCLTDDDT-VWSWGDG 4174

Query: 1043 DYGKLGLGNSTAKSSPQKVDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGLPEG 1222
            DYGKLG G S     P K+D L G+G+ KV CG+QFSVALTK G VYT+G+     L  G
Sbjct: 4175 DYGKLGRGGSDGCKVPMKIDSLTGLGVVKVECGSQFSVALTKSGAVYTWGKGDYHRLGHG 4234

Query: 1223 RARNHNRPQQIPVLAGVVIEDVAVGAEHTLALASTGDVYAWGSNSEGQLGLGHTNHVREP 1402
               +  RP+Q+  L G  +  +A G+ H +     G+VY WG N EGQLG G TN ++ P
Sbjct: 4235 SDDHVRRPRQVQGLQGKKVIAIATGSLHCVCCTEDGEVYTWGDNDEGQLGDGTTNAIQRP 4294

Query: 1403 TLVTVLQGKNVRQISAGRCHSAAWTAPPVPPRAPGVSVPLQLG-LPDAVPPQYGALREVS 1579
             LV  LQGK V +++ G  H+ AW+           S P   G LP  VP +Y  L+E+ 
Sbjct: 4295 RLVAALQGKKVNRVACGSAHTLAWS----------TSKPASAGKLPAQVPMEYNHLQEIP 4344

Query: 1580 IHTARARLRLLYHFSDLMYSSWRLLNLSPNNQNSTSHYNAGTWGIVQGQLRPLLAPRVYT 1759
            I   R RL LL+H S+L      + +L    + S      G   +    LR +L  +   
Sbjct: 4345 IIALRNRLLLLHHISELFCPCIPMFDL----EGSLDETGLGP-SVGFDTLRGILISQGKE 4399

Query: 1760 LPMVRSIGKTMVQGKNYGPQITVKRISTRGRK----------CKPIFVQIARQVVKLNAS 1909
                + +  TMV+ + +GP + + RI  +  +           K +F Q+  ++   +  
Sbjct: 4400 AAFRKVVQATMVRDRQHGPVVELNRIQVKRSRSKGGLAGPDGTKSVFGQMCAKMSSFSPD 4459

Query: 1910 DLRLPSRAWKVKLVGEGADDAGGVFDDTITEMCQELETGIVDLLIPSPNATAEVGYNRDR 2089
             L LP R WKVK VGE  DD GG + ++I E+C+EL+ G+  LLI +PN   E G NRD 
Sbjct: 4460 SLLLPHRVWKVKFVGESVDDCGGGYSESIAEICEELQNGLTPLLIVTPNGRDESGANRDC 4519

Query: 2090 FLFNPSACLDEHLMQFKFLGILMGVAIRTKKPLDLHLAPLVWKQLCCVPXXXXXXXXXXX 2269
            +L NP+     H   F+FLG+L+G+AIRT  PL L+LA  VWKQL  +            
Sbjct: 4520 YLLNPATRAPVHCSMFRFLGVLLGIAIRTGSPLSLNLAEPVWKQLAGMSLTIADLSEVDK 4579

Query: 2270 XYVQTLNSILHIEDSGITEESFHEM-IPLDSFVGQSADGKMVPIIPGGNSIPLTFSNRKE 2446
             ++     +++I D+  T E F  M +P   F   SA G+ + +        +T  NR E
Sbjct: 4580 DFIP---GLMYIRDNEATSEEFEAMSLP---FTVPSASGQDIQL--SSKHTHITLDNRAE 4631

Query: 2447 YVERAIEYRLHEMDRQVAAVREGMSWIVPVPLLSLLTAKQLEQMVCGMPEISVEVLKKVV 2626
            YV  AI YRLHE D QVAAVREGM+ +VPVPLLSL T  +LE MVCG P+I + +LK V 
Sbjct: 4632 YVRLAINYRLHEFDEQVAAVREGMARVVPVPLLSLFTGYELETMVCGSPDIPLHLLKSVA 4691

Query: 2627 RYREVDEQHQLVQWFWHTLEEFSNEERVLFMRFVSGRSRLPANTADISQR-FQIMKVDR- 2800
             Y+ ++    LVQWFW  +E FSN ER LF+RFV GR+RLP   AD   R F I  +D+ 
Sbjct: 4692 TYKGIEPSASLVQWFWEVMESFSNTERSLFLRFVWGRTRLPRTIADFRGRDFVIQVLDKY 4751

Query: 2801 --PYDSLPTSQTCFFQLRLPPYSSQLVMAERLRYAINNCRSIDMDNY 2935
              P   LP S TCFF L+LP YS + V+ E+L+YAI+ C+SID D+Y
Sbjct: 4752 NPPDHFLPESYTCFFLLKLPRYSCKQVLEEKLKYAIHFCKSIDTDDY 4798



 Score =  262 bits (670), Expect = 1e-69
 Identities = 146/343 (42%), Positives = 209/343 (60%), Gaps = 3/343 (0%)
 Frame = +2

Query: 503  GQNCTFVIQANGTVLACGEGSYGRLGQG-NSDDLHVLTVISALQGFVVTQLVTSCGSDGH 679
            G    F +   G V +CGE + GRLG G +S  + +   I+AL  +VV ++    G   H
Sbjct: 3001 GSKSLFAVTVEGKVYSCGEATNGRLGLGMSSGTVPIPRQITALSSYVVKKVAVHSGGR-H 3059

Query: 680  SMALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDG 859
            + ALT  G+VFSWG+GD GKLGH +     +PR IEAL+ + +  ++CG  HSA +TS G
Sbjct: 3060 ATALTVDGKVFSWGEGDDGKLGHFSRMNCDKPRLIEALKTKRIRDIACGSSHSAALTSSG 3119

Query: 860  KLFTFGNGDYGRLGLGNTSNKKLPERVTALEGYQIGQVACGLN--HTLAVSADGSMVWAF 1033
            +L+T+G G+YGRLG G+ + +  P+ V  L G+++ QVACG     TLA++ +G +V+++
Sbjct: 3120 ELYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEG-LVFSW 3178

Query: 1034 GDGDYGKLGLGNSTAKSSPQKVDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGL 1213
            GDGD+GKLG G S   + PQ ++ L G G+ ++ CG QFS+ALTK G V+T+G+     L
Sbjct: 3179 GDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFSLALTKSGVVWTWGKGDYFRL 3238

Query: 1214 PEGRARNHNRPQQIPVLAGVVIEDVAVGAEHTLALASTGDVYAWGSNSEGQLGLGHTNHV 1393
              G   +  +PQ +  L G  I  VAVGA H LA+  +G VYAWG N  GQ G G T   
Sbjct: 3239 GHGSDVHVRKPQVVEGLRGKKIVHVAVGALHCLAVTDSGQVYAWGDNDHGQQGNGTTTVN 3298

Query: 1394 REPTLVTVLQGKNVRQISAGRCHSAAWTAPPVPPRAPGVSVPL 1522
            R+PTLV  L+G+ + +++ G  HS AWT   V    P V  P+
Sbjct: 3299 RKPTLVQGLEGQKITRVACGSSHSVAWTT--VDVATPSVHEPV 3339



 Score =  212 bits (539), Expect = 2e-54
 Identities = 124/340 (36%), Positives = 193/340 (56%), Gaps = 11/340 (3%)
 Frame = +2

Query: 494  VICGQNCTFVIQANGTVLACGEGSYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSD 673
            V C +    ++  NG V            Q  + D+    ++  L    + ++     SD
Sbjct: 457  VACAEKRFLILSRNGRVYT----------QAYNSDMLAPQLVQGLASRNIVKIAAH--SD 504

Query: 674  GHS-MALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEE----VVQMSCGFKHS 838
            GH  +AL  +GEV+SWG GD G+LGHG++     P+ I A  G++    VV ++CG  +S
Sbjct: 505  GHHYLALAATGEVYSWGCGDGGRLGHGDTVPLEEPKVISAFSGKQAGKHVVHIACGSTYS 564

Query: 839  AVVTSDGKLFTFGNGDYGRLGLGNTSNKKLPERVTALEGYQIGQVACGLN--HTLAVSAD 1012
            A +T++G+L+T+G G+YGRLG G++ ++ +P  V  L+G ++  VACG     TLAV+ +
Sbjct: 565  AAITAEGELYTWGRGNYGRLGHGSSEDEAIPMLVAGLKGLKVIDVACGSGDAQTLAVTEN 624

Query: 1013 GSMVWAFGDGDYGKLGLGNSTAKSSPQKVDVLCGIGIKKVACGTQFSVALTKDGHVYTFG 1192
            G  VW++GDGDYGKLG G S    +P+ ++ L  + + KV CG+QFS+ALTKDG VY++G
Sbjct: 625  GQ-VWSWGDGDYGKLGRGGSDGCKTPKLIEKLQDLDVIKVRCGSQFSIALTKDGQVYSWG 683

Query: 1193 QDRLIGLPEGRARNHNRPQQIPVLAGVVIEDVAVGAEHTLALASTGDVYAWGSNSEGQLG 1372
            +     L  G   +   P+ +  L G  + DVA G+ H LAL    +V++WGSN + Q  
Sbjct: 684  KGDNQRLGHGTEEHVRYPKLLEGLQGKKVIDVAAGSTHCLALTEDSEVHSWGSNDQCQ-- 741

Query: 1373 LGHTNHVR----EPTLVTVLQGKNVRQISAGRCHSAAWTA 1480
              H + +R    EPT +  L  K++  I+ G   S AW++
Sbjct: 742  --HFDTLRVTKPEPTALPGLDSKHIVGIACGPAQSFAWSS 779



 Score =  166 bits (421), Expect = 9e-41
 Identities = 100/261 (38%), Positives = 142/261 (54%), Gaps = 4/261 (1%)
 Frame = +2

Query: 395  VYLWGAGRHGQLAEAGR---NVMVXXXXXXXXXXXXVICGQNCTFVIQANGTVLACGEGS 565
            V+ WG G  G+L    R   +               + CG + +  + ++G +   G G 
Sbjct: 3069 VFSWGEGDDGKLGHFSRMNCDKPRLIEALKTKRIRDIACGSSHSAALTSSGELYTWGLGE 3128

Query: 566  YGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGS-DGHSMALTESGEVFSWGDGDYGKL 742
            YGRLG G++       ++  L G  V Q+  +CGS D  ++ALT+ G VFSWGDGD+GKL
Sbjct: 3129 YGRLGHGDNTTQLKPKMVKVLLGHRVIQV--ACGSRDAQTLALTDEGLVFSWGDGDFGKL 3186

Query: 743  GHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLGLGNTSNK 922
            G G S+    P+ IE L G+ V Q+ CG + S  +T  G ++T+G GDY RLG G+  + 
Sbjct: 3187 GRGGSEGCNIPQNIERLNGQGVCQIECGAQFSLALTKSGVVWTWGKGDYFRLGHGSDVHV 3246

Query: 923  KLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNSTAKSSPQKVD 1102
            + P+ V  L G +I  VA G  H LAV+ D   V+A+GD D+G+ G G +T    P  V 
Sbjct: 3247 RKPQVVEGLRGKKIVHVAVGALHCLAVT-DSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQ 3305

Query: 1103 VLCGIGIKKVACGTQFSVALT 1165
             L G  I +VACG+  SVA T
Sbjct: 3306 GLEGQKITRVACGSSHSVAWT 3326



 Score =  155 bits (393), Expect = 2e-37
 Identities = 114/399 (28%), Positives = 186/399 (46%), Gaps = 34/399 (8%)
 Frame = +2

Query: 65   SLAVGLHLDQLL--CNPPV---PPHHQNCLPDPASWNPNEWAW-------LECFSTT--- 199
            ++ V  HLD+L   C PP+   P  H+  L +   W    W +       ++C       
Sbjct: 394  AVVVMAHLDRLATPCMPPLCSSPTSHKGSLQEVIGWGLIGWKYYANVIGPIQCEGLASLG 453

Query: 200  ---IKAAEAL-----TNGAQFPESFSVPDLEPVPEDELVFLMDNSKWINGMDEQIMSWAT 355
               +  AE        NG  + ++++   L P             + + G+  + +    
Sbjct: 454  VMQVACAEKRFLILSRNGRVYTQAYNSDMLAP-------------QLVQGLASRNIVKIA 500

Query: 356  SRPEDWH---LGGKCDVYLWGAGRHGQLA-------EAGRNVMVXXXXXXXXXXXXVICG 505
            +  +  H   L    +VY WG G  G+L        E  + +              + CG
Sbjct: 501  AHSDGHHYLALAATGEVYSWGCGDGGRLGHGDTVPLEEPKVISAFSGKQAGKHVVHIACG 560

Query: 506  QNCTFVIQANGTVLACGEGSYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGS-DGHS 682
               +  I A G +   G G+YGRLG G+S+D  +  +++ L+G  V  +  +CGS D  +
Sbjct: 561  STYSAAITAEGELYTWGRGNYGRLGHGSSEDEAIPMLVAGLKGLKVIDV--ACGSGDAQT 618

Query: 683  MALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGK 862
            +A+TE+G+V+SWGDGDYGKLG G SD  + P+ IE LQ  +V+++ CG + S  +T DG+
Sbjct: 619  LAVTENGQVWSWGDGDYGKLGRGGSDGCKTPKLIEKLQDLDVIKVRCGSQFSIALTKDGQ 678

Query: 863  LFTFGNGDYGRLGLGNTSNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDG 1042
            ++++G GD  RLG G   + + P+ +  L+G ++  VA G  H LA++ D S V ++G  
Sbjct: 679  VYSWGKGDNQRLGHGTEEHVRYPKLLEGLQGKKVIDVAAGSTHCLALTED-SEVHSWGSN 737

Query: 1043 DYGKLGLGNSTAKSSPQKVDVLCGIGIKKVACGTQFSVA 1159
            D  +        K  P  +  L    I  +ACG   S A
Sbjct: 738  DQCQHFDTLRVTKPEPTALPGLDSKHIVGIACGPAQSFA 776



 Score =  137 bits (345), Expect = 6e-32
 Identities = 92/263 (34%), Positives = 134/263 (50%), Gaps = 5/263 (1%)
 Frame = +2

Query: 704  EVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNG 883
            +VF WG  D  +LG     + + P   E L    VVQ++ G K    VT +GK+++ G  
Sbjct: 2961 KVFVWGLNDKDQLGGLKGSKIKVPSFSETLSALNVVQVAGGSKSLFAVTVEGKVYSCGEA 3020

Query: 884  DYGRLGLGNTSNK-KLPERVTALEGYQIGQVA--CGLNHTLAVSADGSMVWAFGDGDYGK 1054
              GRLGLG +S    +P ++TAL  Y + +VA   G  H  A++ DG  V+++G+GD GK
Sbjct: 3021 TNGRLGLGMSSGTVPIPRQITALSSYVVKKVAVHSGGRHATALTVDGK-VFSWGEGDDGK 3079

Query: 1055 LGLGNSTAKSSPQKVDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGLPEGRARN 1234
            LG  +      P+ ++ L    I+ +ACG+  S ALT  G +YT+G      L  G    
Sbjct: 3080 LGHFSRMNCDKPRLIEALKTKRIRDIACGSSHSAALTSSGELYTWGLGEYGRLGHGDNTT 3139

Query: 1235 HNRPQQIPVLAGVVIEDVAVGAE--HTLALASTGDVYAWGSNSEGQLGLGHTNHVREPTL 1408
              +P+ + VL G  +  VA G+    TLAL   G V++WG    G+LG G +     P  
Sbjct: 3140 QLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFSWGDGDFGKLGRGGSEGCNIPQN 3199

Query: 1409 VTVLQGKNVRQISAGRCHSAAWT 1477
            +  L G+ V QI  G   S A T
Sbjct: 3200 IERLNGQGVCQIECGAQFSLALT 3222



 Score = 68.9 bits (167), Expect = 3e-11
 Identities = 47/139 (33%), Positives = 73/139 (52%), Gaps = 8/139 (5%)
 Frame = +2

Query: 1088 PQKVDVLCGIGIKKVACGTQFSVALTKDGHVYT--FGQDRLIGLPEGRARNHNRPQQIPV 1261
            P + + L  +G+ +VAC  +  + L+++G VYT  +  D L             PQ +  
Sbjct: 443  PIQCEGLASLGVMQVACAEKRFLILSRNGRVYTQAYNSDML------------APQLVQG 490

Query: 1262 LAGVVIEDVAVGAE--HTLALASTGDVYAWGSNSEGQLGLGHTNHVREPTLVTVLQ---- 1423
            LA   I  +A  ++  H LALA+TG+VY+WG    G+LG G T  + EP +++       
Sbjct: 491  LASRNIVKIAAHSDGHHYLALAATGEVYSWGCGDGGRLGHGDTVPLEEPKVISAFSGKQA 550

Query: 1424 GKNVRQISAGRCHSAAWTA 1480
            GK+V  I+ G  +SAA TA
Sbjct: 551  GKHVVHIACGSTYSAAITA 569


>ref|NP_780453.1| E3 ubiquitin-protein ligase HECTD3 [Mus musculus].
          Length = 861

 Score =  192 bits (487), Expect = 2e-48
 Identities = 123/349 (35%), Positives = 182/349 (52%), Gaps = 9/349 (2%)
 Frame = +2

Query: 1910 DLRLPSRA---WKVKLVGEGADDAGGVFDDTITEMCQELETGIVDLLIPSP------NAT 2062
            D R P R    W+ K + EG  D GG F D++ +M +EL     D  +P P      N  
Sbjct: 517  DYRWPMRYDQWWECKFIAEGIIDQGGGFRDSLADMSEELCPSSADTPVPLPFFVRTANQG 576

Query: 2063 AEVGYNRDRFLFNPSACLDEHLMQFKFLGILMGVAIRTKKPLDLHLAPLVWKQLCCVPXX 2242
               G  RD ++ NPS C D    +++++G LMG A+R K+ L L L   VWKQL      
Sbjct: 577  NGTGEARDMYVPNPS-CRD--FAKYEWIGQLMGAALRGKEFLVLALPGFVWKQLSGEEVS 633

Query: 2243 XXXXXXXXXXYVQTLNSILHIEDSGITEESFHEMIPLDSFVGQSADGKMVPIIPGGNSIP 2422
                       +  L  ++   D    E  F + +   +F    +D ++V +IPGG  I 
Sbjct: 634  WSKDFPAVDSVLVKLLEVMEGVDKETFEFKFGKEL---TFTTVLSDQQVVELIPGGTGIV 690

Query: 2423 LTFSNRKEYVERAIEYRLHEMDRQVAAVREGMSWIVPVPLLSLLTAKQLEQMVCGMPEIS 2602
            + + +R  +++   + RL E   QVAA++ G+  +VP  +L LLT ++LE+ VCG PE++
Sbjct: 691  VEYEDRSRFIQLVRKARLEESKEQVAAMQAGLLKVVPQAVLDLLTWQELEKKVCGDPEVT 750

Query: 2603 VEVLKKVVRYREVDEQHQLVQWFWHTLEEFSNEERVLFMRFVSGRSRLPANTADISQRFQ 2782
            V+ L+K+ R+ + +     VQ+FW  L  F+NE+R  F+RFV+GRSRLPA       +  
Sbjct: 751  VDALRKLTRFEDFEPSDTRVQYFWEALNNFTNEDRSRFLRFVTGRSRLPARIYIYPDKLG 810

Query: 2783 IMKVDRPYDSLPTSQTCFFQLRLPPYSSQLVMAERLRYAINNCRSIDMD 2929
                    D+LP S TC   L LP Y+S  V  E+LRYA  NC +ID D
Sbjct: 811  Y----ETTDALPESSTCSSTLFLPHYASAKVCEEKLRYAAYNCVAIDTD 855


>ref|NP_082981.3| hect domain and RLD 3 [Mus musculus].
          Length = 1050

 Score =  179 bits (454), Expect = 1e-44
 Identities = 114/325 (35%), Positives = 180/325 (55%), Gaps = 6/325 (1%)
 Frame = +2

Query: 494  VICGQNCTFVIQANGTVLACGEGSYGRLG---QGNSDDLHVLTVISALQGFVVTQLVTSC 664
            V CG N +  +  +G V  CG  + G+LG   +GN  +      I AL    +  +  +C
Sbjct: 39   VACGGNHSVFLLEDGEVYTCGVNTKGQLGHEREGNKPEQ-----IGALADQHIIHV--AC 91

Query: 665  GSDGHSMALTESGEVFSWGDGDYGKLG-HGNSDRQRRPRQIEALQGEEVVQMSCGFKHSA 841
            G + HS+AL++ G++FSWG G  G+LG     D    PR I+ L  + ++Q+SCG  H  
Sbjct: 92   G-ESHSLALSDRGQLFSWGAGSDGQLGLMTTEDSVAVPRLIQKLNQQTILQVSCGNWHCL 150

Query: 842  VVTSDGKLFTFGNGDYGRLGLGNT-SNKKLPERVTALEGYQIGQVACGLNHTLAVSADGS 1018
             + +DG+ FT+G   +G+LGLG    ++  P+RV +LEG  + QVA G  H+ A+S  G+
Sbjct: 151  ALAADGQFFTWGKNSHGQLGLGKEFPSQTSPQRVRSLEGIPLAQVAAGGAHSFALSLSGA 210

Query: 1019 MVWAFGDGDYGKLGLGNSTAKSSPQKVDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQD 1198
             V+ +G  + G+LGL +   + SP  V +L    +  ++CG + +  LTK G V+TFG  
Sbjct: 211  -VFGWGMNNAGQLGLSDEKDRESPCHVKLLRTQKVVYISCGEEHTAVLTKSGGVFTFGAG 269

Query: 1199 RLIGLPEGRARNHNRPQQIPVLAGVVIEDVAVGAEHTLALA-STGDVYAWGSNSEGQLGL 1375
                L      +   P+++  L G  +  +A G +HTLAL  S+G +YA+G  ++GQLG 
Sbjct: 270  SCGQLGHDSVNDEVNPRRVLELMGSEVTQIACGRQHTLALVPSSGLIYAFGCGAKGQLGT 329

Query: 1376 GHTNHVREPTLVTVLQGKNVRQISA 1450
            GHT +V+ P+ V      +  Q+SA
Sbjct: 330  GHTCNVKCPSPVKGHWAAHSSQLSA 354



 Score =  155 bits (391), Expect = 3e-37
 Identities = 105/307 (34%), Positives = 161/307 (52%), Gaps = 5/307 (1%)
 Frame = +2

Query: 566  YGRLGQ-GNSDDLHVLTVISALQGFVVTQLV--TSCGSDGHSMALTESGEVFSWGDGDYG 736
            Y  LGQ G S +L  +     +  FV  + +   +CG + HS+ L E GEV++ G    G
Sbjct: 6    YWSLGQPGISSNLQGIVAEPQVCRFVSDRSIKEVACGGN-HSVFLLEDGEVYTCGVNTKG 64

Query: 737  KLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLGLGNTS 916
            +LGH       +P QI AL  + ++ ++CG  HS  ++  G+LF++G G  G+LGL  T 
Sbjct: 65   QLGHEREGN--KPEQIGALADQHIIHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTE 122

Query: 917  NK-KLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNS-TAKSSP 1090
            +   +P  +  L    I QV+CG  H LA++ADG   + +G   +G+LGLG    +++SP
Sbjct: 123  DSVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQF-FTWGKNSHGQLGLGKEFPSQTSP 181

Query: 1091 QKVDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGLPEGRARNHNRPQQIPVLAG 1270
            Q+V  L GI + +VA G   S AL+  G V+ +G +    L     ++   P  + +L  
Sbjct: 182  QRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEKDRESPCHVKLLRT 241

Query: 1271 VVIEDVAVGAEHTLALASTGDVYAWGSNSEGQLGLGHTNHVREPTLVTVLQGKNVRQISA 1450
              +  ++ G EHT  L  +G V+ +G+ S GQLG    N    P  V  L G  V QI+ 
Sbjct: 242  QKVVYISCGEEHTAVLTKSGGVFTFGAGSCGQLGHDSVNDEVNPRRVLELMGSEVTQIAC 301

Query: 1451 GRCHSAA 1471
            GR H+ A
Sbjct: 302  GRQHTLA 308



 Score =  134 bits (336), Expect = 6e-31
 Identities = 83/262 (31%), Positives = 128/262 (48%), Gaps = 5/262 (1%)
 Frame = +2

Query: 329  DEQIMSWATSRPEDWHLGGKCDVYLWGAGRHGQLA----EAGRNVMVXXXXXXXXXXXXV 496
            D+ I+  A        L  +  ++ WGAG  GQL     E    V              V
Sbjct: 83   DQHIIHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTEDSVAVPRLIQKLNQQTILQV 142

Query: 497  ICGQNCTFVIQANGTVLACGEGSYGRLGQGNSDDLHVLTV-ISALQGFVVTQLVTSCGSD 673
             CG      + A+G     G+ S+G+LG G           + +L+G  + Q+       
Sbjct: 143  SCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQTSPQRVRSLEGIPLAQVAAG---G 199

Query: 674  GHSMALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTS 853
             HS AL+ SG VF WG  + G+LG  +   +  P  ++ L+ ++VV +SCG +H+AV+T 
Sbjct: 200  AHSFALSLSGAVFGWGMNNAGQLGLSDEKDRESPCHVKLLRTQKVVYISCGEEHTAVLTK 259

Query: 854  DGKLFTFGNGDYGRLGLGNTSNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAF 1033
             G +FTFG G  G+LG  + +++  P RV  L G ++ Q+ACG  HTLA+     +++AF
Sbjct: 260  SGGVFTFGAGSCGQLGHDSVNDEVNPRRVLELMGSEVTQIACGRQHTLALVPSSGLIYAF 319

Query: 1034 GDGDYGKLGLGNSTAKSSPQKV 1099
            G G  G+LG G++     P  V
Sbjct: 320  GCGAKGQLGTGHTCNVKCPSPV 341



 Score =  124 bits (310), Expect = 7e-28
 Identities = 82/258 (31%), Positives = 134/258 (51%), Gaps = 4/258 (1%)
 Frame = +2

Query: 716  WGDGDYGKLGHGNSDRQ--RRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDY 889
            WG    G+ G  ++ +     P+    +    + +++CG  HS  +  DG+++T G    
Sbjct: 4    WGYWSLGQPGISSNLQGIVAEPQVCRFVSDRSIKEVACGGNHSVFLLEDGEVYTCGVNTK 63

Query: 890  GRLGLGNTSNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGN 1069
            G+LG     NK  PE++ AL    I  VACG +H+LA+S D   ++++G G  G+LGL  
Sbjct: 64   GQLGHEREGNK--PEQIGALADQHIIHVACGESHSLALS-DRGQLFSWGAGSDGQLGLMT 120

Query: 1070 ST-AKSSPQKVDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGLPEGRA-RNHNR 1243
            +  + + P+ +  L    I +V+CG    +AL  DG  +T+G++    L  G+   +   
Sbjct: 121  TEDSVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQTS 180

Query: 1244 PQQIPVLAGVVIEDVAVGAEHTLALASTGDVYAWGSNSEGQLGLGHTNHVREPTLVTVLQ 1423
            PQ++  L G+ +  VA G  H+ AL+ +G V+ WG N+ GQLGL        P  V +L+
Sbjct: 181  PQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEKDRESPCHVKLLR 240

Query: 1424 GKNVRQISAGRCHSAAWT 1477
             + V  IS G  H+A  T
Sbjct: 241  TQKVVYISCGEEHTAVLT 258



 Score = 95.9 bits (237), Expect = 2e-19
 Identities = 92/338 (27%), Positives = 142/338 (42%), Gaps = 5/338 (1%)
 Frame = +2

Query: 1910 DLRLPSRAWKVKLVGEGADDAGGVFDDTITEMCQELETGIVDLLIPSPNATAEVGYNRDR 2089
            DL+ P    KV   GE   DAGGV  +    + +EL   I  +            Y    
Sbjct: 726  DLKKPL---KVIFDGEEGVDAGGVTKEFFLLLLKELLNPIYGMF---------TYYQDSN 773

Query: 2090 FLFNPSACLDEHLMQFKFLGILMGVAIRTKKPLDLHLAPLVWKQLCCVPXXXXXXXXXXX 2269
             L+    C  EH   F  +GI  G+AI     +DLH    ++K+L  V            
Sbjct: 774  LLWFSDTCFVEHNW-FHLIGITCGLAIYNSTVVDLHFPLALYKKLLNVKPSLEDLKELSP 832

Query: 2270 XYVQTLNSILHIEDSGITEESFHEMIPLDSFVGQSADG--KMVPIIPGGNSIPLTFSNRK 2443
               ++L  +L      I EE+F     L+  V + + G  +   +IPGG+ + +   NR+
Sbjct: 833  TEGRSLQELLDYPGEDI-EETFC----LNFTVCRESYGVIEQKKLIPGGDRVAVCKDNRQ 887

Query: 2444 EYVERAIEYRLH-EMDRQVAAVREGMSWIVPVPLLSLLTAKQLEQMVCGMPEISVEVLKK 2620
            E+V+  + Y     +     A   G   +    +L L    +L  M+ G      E L++
Sbjct: 888  EFVDAYVNYIFQISVHEWYTAFSSGFLKVCGGKVLELFQPAELRAMMVGNSNYDWEELEE 947

Query: 2621 VVRYR-EVDEQHQLVQWFWHTLEEFSNEERVLFMRFVSGRSRLPA-NTADISQRFQIMKV 2794
               YR +    H  V+ FW T  EF  E++  F+ F++G  R+P    A +    Q    
Sbjct: 948  TAVYRGDYSSTHPTVKLFWETFHEFPLEKKKKFLLFLTGSDRIPIYGMASLQIIIQSTAT 1007

Query: 2795 DRPYDSLPTSQTCFFQLRLPPYSSQLVMAERLRYAINN 2908
               Y  LP + TC+  L LP YSS+ +M  RL  A++N
Sbjct: 1008 GEEY--LPVAHTCYNLLDLPKYSSKEIMKARLTQALDN 1043


>ref|NP_084390.1| probable E3 ubiquitin-protein ligase HERC4 isoform 1 [Mus musculus].
          Length = 1057

 Score =  162 bits (409), Expect = 2e-39
 Identities = 105/314 (33%), Positives = 163/314 (51%), Gaps = 3/314 (0%)
 Frame = +2

Query: 542  VLACGEGSYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSD-GHSMALTESGEVFSW 718
            +L  G  SYG+LG G  D+  VL        F V + V   G    H++ + + G V++ 
Sbjct: 1    MLCWGNASYGQLGLGGIDEEIVLE--PRRSDFFVNKKVRDVGCGLRHTVFVLDDGTVYTC 58

Query: 719  GDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRL 898
            G  D G+LGH  S  +++P Q+ AL  + +V ++CG  H+  +   G+++ +G    G+L
Sbjct: 59   GCNDLGQLGHEKS--RKKPEQVVALDAQNIVAVACGEAHTLALNDKGQVYAWGLDSDGQL 116

Query: 899  GL-GNTSNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNST 1075
            GL G+    ++P  + +L   QI QVACG  H+LA+S   S V+ +G   YG+LGLG   
Sbjct: 117  GLQGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSK-ASEVFCWGQNKYGQLGLGIDC 175

Query: 1076 AK-SSPQKVDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGLPEGRARNHNRPQQ 1252
             K +SPQ +  L GI   +VA G   S  LT  G ++ +G+++   L      +   P  
Sbjct: 176  QKQTSPQLIKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNL 235

Query: 1253 IPVLAGVVIEDVAVGAEHTLALASTGDVYAWGSNSEGQLGLGHTNHVREPTLVTVLQGKN 1432
            +  L    I  +  G +HT AL   G V+ +G+   GQLG   T+H   P  V  L G  
Sbjct: 236  LKSLRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSI 295

Query: 1433 VRQISAGRCHSAAW 1474
            V Q++ GR H++A+
Sbjct: 296  VTQVACGRQHTSAF 309



 Score =  161 bits (407), Expect = 4e-39
 Identities = 105/344 (30%), Positives = 170/344 (49%), Gaps = 8/344 (2%)
 Frame = +2

Query: 404  WGAGRHGQLAEAGRNVMVXXXXXXXXXXXX-----VICGQNCTFVIQANGTVLACGEGSY 568
            WG   +GQL   G +  +                 V CG   T  +  +GTV  CG    
Sbjct: 4    WGNASYGQLGLGGIDEEIVLEPRRSDFFVNKKVRDVGCGLRHTVFVLDDGTVYTCGCNDL 63

Query: 569  GRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSDGHSMALTESGEVFSWGDGDYGKLG- 745
            G+LG   S       V    Q  V      +CG + H++AL + G+V++WG    G+LG 
Sbjct: 64   GQLGHEKSRKKPEQVVALDAQNIV----AVACG-EAHTLALNDKGQVYAWGLDSDGQLGL 118

Query: 746  HGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLGLGNTSNKK 925
             G+ +  R PR I++L   ++VQ++CG+ HS  ++   ++F +G   YG+LGLG    K+
Sbjct: 119  QGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGIDCQKQ 178

Query: 926  L-PERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNSTAKSSPQKVD 1102
              P+ + +L G    QVA G  H+  ++  G+ ++ +G   +G+LGL +   +  P  + 
Sbjct: 179  TSPQLIKSLLGIPFMQVAAGGAHSFVLTLSGA-IFGWGRNKFGQLGLNDENDRYVPNLLK 237

Query: 1103 VLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGLPEGRARNHNRPQQIPVLAGVVIE 1282
             L    I  + CG   + ALTK+G V+TFG      L      +   P+++  L G ++ 
Sbjct: 238  SLRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVT 297

Query: 1283 DVAVGAEHTLA-LASTGDVYAWGSNSEGQLGLGHTNHVREPTLV 1411
             VA G +HT A + S+G +Y++G    GQLG G T++ + P  V
Sbjct: 298  QVACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRKSPFTV 341



 Score =  150 bits (380), Expect = 5e-36
 Identities = 93/258 (36%), Positives = 137/258 (53%), Gaps = 4/258 (1%)
 Frame = +2

Query: 716  WGDGDYGKLGHGNSDRQ--RRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDY 889
            WG+  YG+LG G  D +    PR+ +    ++V  + CG +H+  V  DG ++T G  D 
Sbjct: 4    WGNASYGQLGLGGIDEEIVLEPRRSDFFVNKKVRDVGCGLRHTVFVLDDGTVYTCGCNDL 63

Query: 890  GRLGLGNTSNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGL-G 1066
            G+LG  +  ++K PE+V AL+   I  VACG  HTLA++ D   V+A+G    G+LGL G
Sbjct: 64   GQLG--HEKSRKKPEQVVALDAQNIVAVACGEAHTLALN-DKGQVYAWGLDSDGQLGLQG 120

Query: 1067 NSTAKSSPQKVDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGLPEG-RARNHNR 1243
            +      P+ +  L  I I +VACG   S+AL+K   V+ +GQ++   L  G   +    
Sbjct: 121  SEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGIDCQKQTS 180

Query: 1244 PQQIPVLAGVVIEDVAVGAEHTLALASTGDVYAWGSNSEGQLGLGHTNHVREPTLVTVLQ 1423
            PQ I  L G+    VA G  H+  L  +G ++ WG N  GQLGL   N    P L+  L+
Sbjct: 181  PQLIKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLR 240

Query: 1424 GKNVRQISAGRCHSAAWT 1477
             + +  I  G  H+AA T
Sbjct: 241  SQKIVYICCGEDHTAALT 258



 Score =  130 bits (327), Expect = 7e-30
 Identities = 77/257 (29%), Positives = 121/257 (47%), Gaps = 4/257 (1%)
 Frame = +2

Query: 332  EQIMSWATSRPEDWHLGGKCDVYLWGAGRHGQLAEAGRNVMVXXXXXXXXXXXX----VI 499
            + I++ A        L  K  VY WG    GQL   G    +                V 
Sbjct: 84   QNIVAVACGEAHTLALNDKGQVYAWGLDSDGQLGLQGSEECIRVPRNIKSLSDIQIVQVA 143

Query: 500  CGQNCTFVIQANGTVLACGEGSYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSDGH 679
            CG   +  +     V   G+  YG+LG G   D    T    ++  +    +       H
Sbjct: 144  CGYYHSLALSKASEVFCWGQNKYGQLGLGI--DCQKQTSPQLIKSLLGIPFMQVAAGGAH 201

Query: 680  SMALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDG 859
            S  LT SG +F WG   +G+LG  + + +  P  +++L+ +++V + CG  H+A +T +G
Sbjct: 202  SFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKEG 261

Query: 860  KLFTFGNGDYGRLGLGNTSNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGD 1039
             +FTFG G YG+LG  +TS++  P +V  L G  + QVACG  HT A       +++FG 
Sbjct: 262  GVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTQVACGRQHTSAFVPSSGRIYSFGL 321

Query: 1040 GDYGKLGLGNSTAKSSP 1090
            G  G+LG G+++ + SP
Sbjct: 322  GGNGQLGTGSTSNRKSP 338



 Score =  111 bits (277), Expect = 4e-24
 Identities = 65/206 (31%), Positives = 107/206 (51%), Gaps = 5/206 (2%)
 Frame = +2

Query: 329 DEQIMSWATSRPEDWHLGGKCDVYLWGAGRHGQLAEA----GRNVMVXXXXXXXXXXXXV 496
           D QI+  A        L    +V+ WG  ++GQL        +                V
Sbjct: 136 DIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGIDCQKQTSPQLIKSLLGIPFMQV 195

Query: 497 ICGQNCTFVIQANGTVLACGEGSYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSDG 676
             G   +FV+  +G +   G   +G+LG  + +D +V  ++ +L+     ++V  C  + 
Sbjct: 196 AAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLRS---QKIVYICCGED 252

Query: 677 HSMALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKH-SAVVTS 853
           H+ ALT+ G VF++G G YG+LGH ++  +  PR++  L G  V Q++CG +H SA V S
Sbjct: 253 HTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTQVACGRQHTSAFVPS 312

Query: 854 DGKLFTFGNGDYGRLGLGNTSNKKLP 931
            G++++FG G  G+LG G+TSN+K P
Sbjct: 313 SGRIYSFGLGGNGQLGTGSTSNRKSP 338



 Score = 70.5 bits (171), Expect = 9e-12
 Identities = 79/329 (24%), Positives = 137/329 (41%), Gaps = 5/329 (1%)
 Frame = +2

Query: 1937 KVKLVGEGADDAGGVFDDTITEMCQELETGIVDLLIPSPNATAEVGYNRDRFL-FNPSAC 2113
            KV  VGE A DAGGV  +    + +EL           P       Y   R + F+    
Sbjct: 739  KVIFVGEDAVDAGGVRKEFFLLIMRELL---------DPKYGMFRYYEDSRLIWFSDKTF 789

Query: 2114 LDEHLMQFKFLGILMGVAIRTKKPLDLHLAPLVWKQLCCVPXXXXXXXXXXXXYVQTLNS 2293
             D  L  F  +G++ G+AI     +DLH    ++K+L                  +++  
Sbjct: 790  EDSDL--FHLIGVICGLAIYNFTIVDLHFPLALYKKLLKRKPSLDDLKELMPAVGRSMQQ 847

Query: 2294 ILHIEDSGITEESF--HEMIPLDSFVGQSADGKMVPIIPGGNSIPLTFSNRKEYVERAIE 2467
            +L   +  I EE+F  +  I +++F       ++  ++  G    +   NR+E+V+  ++
Sbjct: 848  LLDYPEDDI-EETFCLNFTITVENFGAT----EVKELVLNGADTAVNRQNRQEFVDAYVD 902

Query: 2468 YRLHEMDRQVA-AVREGMSWIVPVPLLSLLTAKQLEQMVCGMPEISVEVLKKVVRYR-EV 2641
            Y  ++    +  A   G   +    +L L    +L+ MV G      + L+K   Y+ E 
Sbjct: 903  YIFNKSVASLFDAFHAGFHKVCGGKVLLLFQPNELQAMVIGNTNYDWKELEKNTEYKGEY 962

Query: 2642 DEQHQLVQWFWHTLEEFSNEERVLFMRFVSGRSRLPANTADISQRFQIMKVDRPYDSLPT 2821
               H  ++ FW    E   E++  F+ F++G  R+P      S +  I         LP 
Sbjct: 963  WADHPTIKIFWEVFHELPLEKKKQFLLFLTGSDRIPI-LGMKSLKLVIQSTGGGESYLPV 1021

Query: 2822 SQTCFFQLRLPPYSSQLVMAERLRYAINN 2908
            S TCF  L LP Y+ +  +  +L  AI++
Sbjct: 1022 SHTCFNLLDLPKYTEKETLRCKLIQAIDH 1050


>ref|NP_080377.2| probable E3 ubiquitin-protein ligase HERC4 isoform 2 [Mus musculus].
          Length = 1049

 Score =  162 bits (409), Expect = 2e-39
 Identities = 105/314 (33%), Positives = 163/314 (51%), Gaps = 3/314 (0%)
 Frame = +2

Query: 542  VLACGEGSYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSD-GHSMALTESGEVFSW 718
            +L  G  SYG+LG G  D+  VL        F V + V   G    H++ + + G V++ 
Sbjct: 1    MLCWGNASYGQLGLGGIDEEIVLE--PRRSDFFVNKKVRDVGCGLRHTVFVLDDGTVYTC 58

Query: 719  GDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRL 898
            G  D G+LGH  S  +++P Q+ AL  + +V ++CG  H+  +   G+++ +G    G+L
Sbjct: 59   GCNDLGQLGHEKS--RKKPEQVVALDAQNIVAVACGEAHTLALNDKGQVYAWGLDSDGQL 116

Query: 899  GL-GNTSNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNST 1075
            GL G+    ++P  + +L   QI QVACG  H+LA+S   S V+ +G   YG+LGLG   
Sbjct: 117  GLQGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSK-ASEVFCWGQNKYGQLGLGIDC 175

Query: 1076 AK-SSPQKVDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGLPEGRARNHNRPQQ 1252
             K +SPQ +  L GI   +VA G   S  LT  G ++ +G+++   L      +   P  
Sbjct: 176  QKQTSPQLIKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNL 235

Query: 1253 IPVLAGVVIEDVAVGAEHTLALASTGDVYAWGSNSEGQLGLGHTNHVREPTLVTVLQGKN 1432
            +  L    I  +  G +HT AL   G V+ +G+   GQLG   T+H   P  V  L G  
Sbjct: 236  LKSLRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSI 295

Query: 1433 VRQISAGRCHSAAW 1474
            V Q++ GR H++A+
Sbjct: 296  VTQVACGRQHTSAF 309



 Score =  161 bits (407), Expect = 4e-39
 Identities = 105/344 (30%), Positives = 170/344 (49%), Gaps = 8/344 (2%)
 Frame = +2

Query: 404  WGAGRHGQLAEAGRNVMVXXXXXXXXXXXX-----VICGQNCTFVIQANGTVLACGEGSY 568
            WG   +GQL   G +  +                 V CG   T  +  +GTV  CG    
Sbjct: 4    WGNASYGQLGLGGIDEEIVLEPRRSDFFVNKKVRDVGCGLRHTVFVLDDGTVYTCGCNDL 63

Query: 569  GRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSDGHSMALTESGEVFSWGDGDYGKLG- 745
            G+LG   S       V    Q  V      +CG + H++AL + G+V++WG    G+LG 
Sbjct: 64   GQLGHEKSRKKPEQVVALDAQNIV----AVACG-EAHTLALNDKGQVYAWGLDSDGQLGL 118

Query: 746  HGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLGLGNTSNKK 925
             G+ +  R PR I++L   ++VQ++CG+ HS  ++   ++F +G   YG+LGLG    K+
Sbjct: 119  QGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGIDCQKQ 178

Query: 926  L-PERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNSTAKSSPQKVD 1102
              P+ + +L G    QVA G  H+  ++  G+ ++ +G   +G+LGL +   +  P  + 
Sbjct: 179  TSPQLIKSLLGIPFMQVAAGGAHSFVLTLSGA-IFGWGRNKFGQLGLNDENDRYVPNLLK 237

Query: 1103 VLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGLPEGRARNHNRPQQIPVLAGVVIE 1282
             L    I  + CG   + ALTK+G V+TFG      L      +   P+++  L G ++ 
Sbjct: 238  SLRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVT 297

Query: 1283 DVAVGAEHTLA-LASTGDVYAWGSNSEGQLGLGHTNHVREPTLV 1411
             VA G +HT A + S+G +Y++G    GQLG G T++ + P  V
Sbjct: 298  QVACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRKSPFTV 341



 Score =  150 bits (380), Expect = 5e-36
 Identities = 93/258 (36%), Positives = 137/258 (53%), Gaps = 4/258 (1%)
 Frame = +2

Query: 716  WGDGDYGKLGHGNSDRQ--RRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDY 889
            WG+  YG+LG G  D +    PR+ +    ++V  + CG +H+  V  DG ++T G  D 
Sbjct: 4    WGNASYGQLGLGGIDEEIVLEPRRSDFFVNKKVRDVGCGLRHTVFVLDDGTVYTCGCNDL 63

Query: 890  GRLGLGNTSNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGL-G 1066
            G+LG  +  ++K PE+V AL+   I  VACG  HTLA++ D   V+A+G    G+LGL G
Sbjct: 64   GQLG--HEKSRKKPEQVVALDAQNIVAVACGEAHTLALN-DKGQVYAWGLDSDGQLGLQG 120

Query: 1067 NSTAKSSPQKVDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGLPEG-RARNHNR 1243
            +      P+ +  L  I I +VACG   S+AL+K   V+ +GQ++   L  G   +    
Sbjct: 121  SEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGIDCQKQTS 180

Query: 1244 PQQIPVLAGVVIEDVAVGAEHTLALASTGDVYAWGSNSEGQLGLGHTNHVREPTLVTVLQ 1423
            PQ I  L G+    VA G  H+  L  +G ++ WG N  GQLGL   N    P L+  L+
Sbjct: 181  PQLIKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLR 240

Query: 1424 GKNVRQISAGRCHSAAWT 1477
             + +  I  G  H+AA T
Sbjct: 241  SQKIVYICCGEDHTAALT 258



 Score =  130 bits (327), Expect = 7e-30
 Identities = 77/257 (29%), Positives = 121/257 (47%), Gaps = 4/257 (1%)
 Frame = +2

Query: 332  EQIMSWATSRPEDWHLGGKCDVYLWGAGRHGQLAEAGRNVMVXXXXXXXXXXXX----VI 499
            + I++ A        L  K  VY WG    GQL   G    +                V 
Sbjct: 84   QNIVAVACGEAHTLALNDKGQVYAWGLDSDGQLGLQGSEECIRVPRNIKSLSDIQIVQVA 143

Query: 500  CGQNCTFVIQANGTVLACGEGSYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSDGH 679
            CG   +  +     V   G+  YG+LG G   D    T    ++  +    +       H
Sbjct: 144  CGYYHSLALSKASEVFCWGQNKYGQLGLGI--DCQKQTSPQLIKSLLGIPFMQVAAGGAH 201

Query: 680  SMALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDG 859
            S  LT SG +F WG   +G+LG  + + +  P  +++L+ +++V + CG  H+A +T +G
Sbjct: 202  SFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKEG 261

Query: 860  KLFTFGNGDYGRLGLGNTSNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGD 1039
             +FTFG G YG+LG  +TS++  P +V  L G  + QVACG  HT A       +++FG 
Sbjct: 262  GVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTQVACGRQHTSAFVPSSGRIYSFGL 321

Query: 1040 GDYGKLGLGNSTAKSSP 1090
            G  G+LG G+++ + SP
Sbjct: 322  GGNGQLGTGSTSNRKSP 338



 Score =  111 bits (277), Expect = 4e-24
 Identities = 65/206 (31%), Positives = 107/206 (51%), Gaps = 5/206 (2%)
 Frame = +2

Query: 329 DEQIMSWATSRPEDWHLGGKCDVYLWGAGRHGQLAEA----GRNVMVXXXXXXXXXXXXV 496
           D QI+  A        L    +V+ WG  ++GQL        +                V
Sbjct: 136 DIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGIDCQKQTSPQLIKSLLGIPFMQV 195

Query: 497 ICGQNCTFVIQANGTVLACGEGSYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSDG 676
             G   +FV+  +G +   G   +G+LG  + +D +V  ++ +L+     ++V  C  + 
Sbjct: 196 AAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLRS---QKIVYICCGED 252

Query: 677 HSMALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKH-SAVVTS 853
           H+ ALT+ G VF++G G YG+LGH ++  +  PR++  L G  V Q++CG +H SA V S
Sbjct: 253 HTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTQVACGRQHTSAFVPS 312

Query: 854 DGKLFTFGNGDYGRLGLGNTSNKKLP 931
            G++++FG G  G+LG G+TSN+K P
Sbjct: 313 SGRIYSFGLGGNGQLGTGSTSNRKSP 338



 Score = 70.5 bits (171), Expect = 9e-12
 Identities = 79/329 (24%), Positives = 137/329 (41%), Gaps = 5/329 (1%)
 Frame = +2

Query: 1937 KVKLVGEGADDAGGVFDDTITEMCQELETGIVDLLIPSPNATAEVGYNRDRFL-FNPSAC 2113
            KV  VGE A DAGGV  +    + +EL           P       Y   R + F+    
Sbjct: 731  KVIFVGEDAVDAGGVRKEFFLLIMRELL---------DPKYGMFRYYEDSRLIWFSDKTF 781

Query: 2114 LDEHLMQFKFLGILMGVAIRTKKPLDLHLAPLVWKQLCCVPXXXXXXXXXXXXYVQTLNS 2293
             D  L  F  +G++ G+AI     +DLH    ++K+L                  +++  
Sbjct: 782  EDSDL--FHLIGVICGLAIYNFTIVDLHFPLALYKKLLKRKPSLDDLKELMPAVGRSMQQ 839

Query: 2294 ILHIEDSGITEESF--HEMIPLDSFVGQSADGKMVPIIPGGNSIPLTFSNRKEYVERAIE 2467
            +L   +  I EE+F  +  I +++F       ++  ++  G    +   NR+E+V+  ++
Sbjct: 840  LLDYPEDDI-EETFCLNFTITVENFGAT----EVKELVLNGADTAVNRQNRQEFVDAYVD 894

Query: 2468 YRLHEMDRQVA-AVREGMSWIVPVPLLSLLTAKQLEQMVCGMPEISVEVLKKVVRYR-EV 2641
            Y  ++    +  A   G   +    +L L    +L+ MV G      + L+K   Y+ E 
Sbjct: 895  YIFNKSVASLFDAFHAGFHKVCGGKVLLLFQPNELQAMVIGNTNYDWKELEKNTEYKGEY 954

Query: 2642 DEQHQLVQWFWHTLEEFSNEERVLFMRFVSGRSRLPANTADISQRFQIMKVDRPYDSLPT 2821
               H  ++ FW    E   E++  F+ F++G  R+P      S +  I         LP 
Sbjct: 955  WADHPTIKIFWEVFHELPLEKKKQFLLFLTGSDRIPI-LGMKSLKLVIQSTGGGESYLPV 1013

Query: 2822 SQTCFFQLRLPPYSSQLVMAERLRYAINN 2908
            S TCF  L LP Y+ +  +  +L  AI++
Sbjct: 1014 SHTCFNLLDLPKYTEKETLRCKLIQAIDH 1042


>ref|NP_080268.1| hect domain and RLD 5 [Mus musculus].
          Length = 1003

 Score =  153 bits (387), Expect = 8e-37
 Identities = 108/360 (30%), Positives = 180/360 (50%), Gaps = 12/360 (3%)
 Frame = +2

Query: 503  GQNCTFVIQANGTVLACGEGSYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSDGHS 682
            G++ + ++ +N  V +CG+ S+G+LGQ           I AL    V   + SCG + HS
Sbjct: 30   GEHHSLLLFSNHRVYSCGDNSWGQLGQRRDQSTERPEPIQALNDLHVD--LVSCGKE-HS 86

Query: 683  MALTESGEVFSWGDGDYGKLGHGN-SDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDG 859
            +A+   G+VF+WG G  G+LG G   +    P +I+AL G +++Q+SCG  HS  ++ DG
Sbjct: 87   VAVCHKGKVFAWGAGSEGQLGIGEFKEISFMPTKIKALAGIKIIQVSCGHYHSLALSEDG 146

Query: 860  KLFTFGNGDYGRLGLG-NTSNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFG 1036
             +F++G    G+LGLG N+ ++ +P++V +LEG  + QVA G  H+ A+S  G+  + +G
Sbjct: 147  HVFSWGRNSEGQLGLGKNSRSQAIPQKVKSLEGIPLAQVAAGGTHSFALSLTGTS-FGWG 205

Query: 1037 DGDYGKLGLGNSTAKSS---PQKVDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLI 1207
                G+L L  +  K     P  +  L  + +  ++CG + +  LT++G V+TFG +   
Sbjct: 206  SNRSGQLALSGNKVKEQIYKPHSIGALKNLSVIYISCGYEHTAVLTEEGQVFTFGGNSSG 265

Query: 1208 GLPEGRARNHNRPQQIPVLAGVVIEDVAVGAEHTLA-LASTGDVYAWGSNSEGQLGLGHT 1384
             L          PQ I  + G V   +   + HT+A + +TG V + G          H 
Sbjct: 266  QLQPSPRSGQRGPQLIEGIGGRV-SQIECASYHTIAYVYTTGQVVSLGRGPSHTSNPTHQ 324

Query: 1385 NHVREPTLVTVLQGK------NVRQISAGRCHSAAWTAPPVPPRAPGVSVPLQLGLPDAV 1546
                E + +T L          V+ I AG   +   T      R+ GVS+ +   LP+ +
Sbjct: 325  EAPAENSDITCLLAAEDLVDIEVKDIFAGAHANFVTTRRVSHTRSTGVSMKI---LPEII 381



 Score =  152 bits (385), Expect = 1e-36
 Identities = 98/281 (34%), Positives = 150/281 (53%), Gaps = 5/281 (1%)
 Frame = +2

Query: 647  QLVTSCGSDGHSMALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCG 826
            +L+ +   + HS+ L  +  V+S GD  +G+LG        RP  I+AL    V  +SCG
Sbjct: 23   ELLQAASGEHHSLLLFSNHRVYSCGDNSWGQLGQRRDQSTERPEPIQALNDLHVDLVSCG 82

Query: 827  FKHSAVVTSDGKLFTFGNGDYGRLGLGNTSN-KKLPERVTALEGYQIGQVACGLNHTLAV 1003
             +HS  V   GK+F +G G  G+LG+G       +P ++ AL G +I QV+CG  H+LA+
Sbjct: 83   KEHSVAVCHKGKVFAWGAGSEGQLGIGEFKEISFMPTKIKALAGIKIIQVSCGHYHSLAL 142

Query: 1004 SADGSMVWAFGDGDYGKLGLG-NSTAKSSPQKVDVLCGIGIKKVACGTQFSVALTKDGHV 1180
            S DG  V+++G    G+LGLG NS +++ PQKV  L GI + +VA G   S AL+  G  
Sbjct: 143  SEDGH-VFSWGRNSEGQLGLGKNSRSQAIPQKVKSLEGIPLAQVAAGGTHSFALSLTGTS 201

Query: 1181 YTFGQDR--LIGLPEGRARNH-NRPQQIPVLAGVVIEDVAVGAEHTLALASTGDVYAWGS 1351
            + +G +R   + L   + +    +P  I  L  + +  ++ G EHT  L   G V+ +G 
Sbjct: 202  FGWGSNRSGQLALSGNKVKEQIYKPHSIGALKNLSVIYISCGYEHTAVLTEEGQVFTFGG 261

Query: 1352 NSEGQLGLGHTNHVREPTLVTVLQGKNVRQISAGRCHSAAW 1474
            NS GQL     +  R P L+  + G+ V QI     H+ A+
Sbjct: 262  NSSGQLQPSPRSGQRGPQLIEGIGGR-VSQIECASYHTIAY 301



 Score =  100 bits (248), Expect = 1e-20
 Identities = 72/251 (28%), Positives = 119/251 (47%), Gaps = 9/251 (3%)
 Frame = +2

Query: 386  KCDVYLWGAGRHGQLAEAG-RNVMVXXXXXXXXXXXXVI---CGQNCTFVIQANGTVLAC 553
            K  V+ WGAG  GQL     + +              +I   CG   +  +  +G V + 
Sbjct: 92   KGKVFAWGAGSEGQLGIGEFKEISFMPTKIKALAGIKIIQVSCGHYHSLALSEDGHVFSW 151

Query: 554  GEGSYGRLGQG-NSDDLHVLTVISALQGFVVTQLVTSCGSDGHSMALTESGEVFSWGDGD 730
            G  S G+LG G NS    +   + +L+G  + Q+        HS AL+ +G  F WG   
Sbjct: 152  GRNSEGQLGLGKNSRSQAIPQKVKSLEGIPLAQV---AAGGTHSFALSLTGTSFGWGSNR 208

Query: 731  YGKLG-HGNSDRQR--RPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLG 901
             G+L   GN  +++  +P  I AL+   V+ +SCG++H+AV+T +G++FTFG    G+L 
Sbjct: 209  SGQLALSGNKVKEQIYKPHSIGALKNLSVIYISCGYEHTAVLTEEGQVFTFGGNSSGQLQ 268

Query: 902  LGNTSNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNSTAK 1081
                S ++ P+ +  + G ++ Q+ C   HT+A       V + G    G     N T +
Sbjct: 269  PSPRSGQRGPQLIEGIGG-RVSQIECASYHTIAYVYTTGQVVSLG---RGPSHTSNPTHQ 324

Query: 1082 SSP-QKVDVLC 1111
             +P +  D+ C
Sbjct: 325  EAPAENSDITC 335



 Score = 75.5 bits (184), Expect = 3e-13
 Identities = 42/121 (34%), Positives = 66/121 (54%), Gaps = 1/121 (0%)
 Frame = +2

Query: 1112 GIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGLPEGRARNHNRPQQIPVLAGVVIEDVA 1291
            GI + + A G   S+ L  +  VY+ G +    L + R ++  RP+ I  L  + ++ V+
Sbjct: 21   GIELLQAASGEHHSLLLFSNHRVYSCGDNSWGQLGQRRDQSTERPEPIQALNDLHVDLVS 80

Query: 1292 VGAEHTLALASTGDVYAWGSNSEGQLGLGHTNHVR-EPTLVTVLQGKNVRQISAGRCHSA 1468
             G EH++A+   G V+AWG+ SEGQLG+G    +   PT +  L G  + Q+S G  HS 
Sbjct: 81   CGKEHSVAVCHKGKVFAWGAGSEGQLGIGEFKEISFMPTKIKALAGIKIIQVSCGHYHSL 140

Query: 1469 A 1471
            A
Sbjct: 141  A 141



 Score = 69.3 bits (168), Expect = 2e-11
 Identities = 76/346 (21%), Positives = 142/346 (41%), Gaps = 4/346 (1%)
 Frame = +2

Query: 1883 RQVVKLNASDLRLPSRAWKVKLVGEGADDAGGVFDDTITEMCQELETGIVDLLIPSPNAT 2062
            RQ+ ++   DLR   +   V  + E   +AGGV  +    + +E+     ++ I     +
Sbjct: 673  RQLRQVEDFDLR---KQLSVGFINEIRPEAGGVSSEFFHCIFEEMTDPKYEMFIYPEKGS 729

Query: 2063 AEVGYNRDRFLFNPSACLDEHLMQFKFLGILMGVAIRTKKPLDLHLAPLVWKQLCCVPXX 2242
            +        F  NP     E    F F GIL G+++   K ++L     ++K+L      
Sbjct: 730  SMW------FPVNPKF---EKSSYFLF-GILCGLSLHNLKVINLPFPLALYKKLLNQKPS 779

Query: 2243 XXXXXXXXXXYVQTLNSILHIEDSGITEESFHEMIPLDSFVGQSADGKMVPIIPGGNSIP 2422
                        + L  +L+ E   I E        L  +     D K V +IP G S+P
Sbjct: 780  LEDLKELSLPLGRNLQEVLNCEAGDIEE--------LHMYFSIYWDQKDVDLIPDGISVP 831

Query: 2423 LTFSNRKEYVERAIEYRLHEMDRQV-AAVREGMSWIVPVPLLSLLTAKQLEQMVCGMPEI 2599
            +  +N+++YV + ++Y  +   + +      G   +    ++     ++L   + G    
Sbjct: 832  VNETNKRDYVSKYVDYIFNISIKTIYEEFHRGFYKVCNWDIIRQFQPEELMTAIIGNATC 891

Query: 2600 SVEVLKKVVRYRE-VDEQHQLVQWFWHTLEEFSNEERVLFMRFVSGRSRLPANTADISQR 2776
              +  +   +Y++  D+ H  +  FW    + + +E+  F+ F++G  RL  +   +   
Sbjct: 892  DWKQFENNSKYKDGYDKSHPTILLFWKAFHDLTLDEKKKFLLFLTGCDRL--HVKGLQNE 949

Query: 2777 FQIMKVDRPY--DSLPTSQTCFFQLRLPPYSSQLVMAERLRYAINN 2908
              + +    +  +  P S TC   L LP YSS   M E L+ AINN
Sbjct: 950  GIVFRCSETFSEEDNPRSLTCHRMLDLPKYSSMRRMKEALQVAINN 995


>ref|NP_001164165.1| RCC1 and BTB domain-containing protein 2 [Mus musculus].
          Length = 551

 Score =  152 bits (385), Expect = 1e-36
 Identities = 96/289 (33%), Positives = 151/289 (52%), Gaps = 3/289 (1%)
 Frame = +2

Query: 533  NGTVLACGEGSYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSDGHSMALTESGEVF 712
            N  +   G    G LG G+         + +L G  +  L  S GS  H +  T  GEVF
Sbjct: 64   NDEIFVLGTNCSGCLGVGDIQSTIEPRRLDSLTGKKIASL--SYGSGPHIVLATTDGEVF 121

Query: 713  SWGDGDYGKLGHGNSDRQRRPRQIEA-LQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDY 889
            +WG   Y +LG+G ++    P  I   L  ++V++++CG  HS V+TSDG++F +G  + 
Sbjct: 122  TWGHNAYSQLGNGTTNHGLVPCHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWGYNNS 181

Query: 890  GRLGLGNTSNKKLPERVTA-LEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLG 1066
            G++G G+T+N+ +P RVT  L+   +  +ACG   ++AV  D   V+ +G    G+LGLG
Sbjct: 182  GQVGSGSTANQPIPRRVTGCLQNKVVMNIACGQMCSMAV-VDTGEVYVWGYNGNGQLGLG 240

Query: 1067 NSTAKSSPQKVDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGLPEGRARNHNRP 1246
            +S  + +P +V  L GI +++VACG   ++ LT +G +Y +G +    L  G   N + P
Sbjct: 241  SSGNQPTPCRVAALQGIRVQRVACGYAHTLVLTDEGQIYAWGANSYGQLGTGNKSNQSYP 300

Query: 1247 QQIPVLAGVVIEDVAVGAEHTLALAST-GDVYAWGSNSEGQLGLGHTNH 1390
              + V    +IE  A  + HT A  +  G VY WG      + L H  H
Sbjct: 301  TPVVVEKDRIIEIAACHSAHTSAAKTQGGHVYMWGQCRGQSVILPHHTH 349



 Score =  151 bits (382), Expect = 3e-36
 Identities = 95/276 (34%), Positives = 154/276 (55%), Gaps = 4/276 (1%)
 Frame = +2

Query: 665  GSDGHSMALTE-SGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGF-KHS 838
            GS G+ +  T  + E+F  G    G LG G+      PR++++L G+++  +S G   H 
Sbjct: 52   GSAGNEVLYTTVNDEIFVLGTNCSGCLGVGDIQSTIEPRRLDSLTGKKIASLSYGSGPHI 111

Query: 839  AVVTSDGKLFTFGNGDYGRLGLGNTSNKKLPERV-TALEGYQIGQVACGLNHTLAVSADG 1015
             + T+DG++FT+G+  Y +LG G T++  +P  + T L   Q+ +VACG  H+L +++DG
Sbjct: 112  VLATTDGEVFTWGHNAYSQLGNGTTNHGLVPCHISTNLSNKQVIEVACGSYHSLVLTSDG 171

Query: 1016 SMVWAFGDGDYGKLGLGNSTAKSSPQKVD-VLCGIGIKKVACGTQFSVALTKDGHVYTFG 1192
              V+A+G  + G++G G++  +  P++V   L    +  +ACG   S+A+   G VY +G
Sbjct: 172  E-VFAWGYNNSGQVGSGSTANQPIPRRVTGCLQNKVVMNIACGQMCSMAVVDTGEVYVWG 230

Query: 1193 QDRLIGLPEGRARNHNRPQQIPVLAGVVIEDVAVGAEHTLALASTGDVYAWGSNSEGQLG 1372
             +    L  G + N   P ++  L G+ ++ VA G  HTL L   G +YAWG+NS GQLG
Sbjct: 231  YNGNGQLGLGSSGNQPTPCRVAALQGIRVQRVACGYAHTLVLTDEGQIYAWGANSYGQLG 290

Query: 1373 LGHTNHVREPTLVTVLQGKNVRQISAGRCHSAAWTA 1480
             G+ ++   PT V V   +  R I    CHSA  +A
Sbjct: 291  TGNKSNQSYPTPVVV---EKDRIIEIAACHSAHTSA 323



 Score =  113 bits (282), Expect = 1e-24
 Identities = 72/220 (32%), Positives = 113/220 (51%), Gaps = 5/220 (2%)
 Frame = +2

Query: 392  DVYLWGAGRHGQLAEAGRNV-MVXXXXXXXXXXXXVI---CGQNCTFVIQANGTVLACGE 559
            +V+ WG   + QL     N  +V            VI   CG   + V+ ++G V A G 
Sbjct: 119  EVFTWGHNAYSQLGNGTTNHGLVPCHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWGY 178

Query: 560  GSYGRLGQGNSDDLHV-LTVISALQGFVVTQLVTSCGSDGHSMALTESGEVFSWGDGDYG 736
             + G++G G++ +  +   V   LQ  VV  +  +CG    SMA+ ++GEV+ WG    G
Sbjct: 179  NNSGQVGSGSTANQPIPRRVTGCLQNKVVMNI--ACGQMC-SMAVVDTGEVYVWGYNGNG 235

Query: 737  KLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLGLGNTS 916
            +LG G+S  Q  P ++ ALQG  V +++CG+ H+ V+T +G+++ +G   YG+LG GN S
Sbjct: 236  QLGLGSSGNQPTPCRVAALQGIRVQRVACGYAHTLVLTDEGQIYAWGANSYGQLGTGNKS 295

Query: 917  NKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFG 1036
            N+  P  V   +   I   AC   HT A    G  V+ +G
Sbjct: 296  NQSYPTPVVVEKDRIIEIAACHSAHTSAAKTQGGHVYMWG 335


>ref|NP_598844.3| RCC1 and BTB domain-containing protein 2 [Mus musculus].
          Length = 551

 Score =  152 bits (385), Expect = 1e-36
 Identities = 96/289 (33%), Positives = 151/289 (52%), Gaps = 3/289 (1%)
 Frame = +2

Query: 533  NGTVLACGEGSYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSDGHSMALTESGEVF 712
            N  +   G    G LG G+         + +L G  +  L  S GS  H +  T  GEVF
Sbjct: 64   NDEIFVLGTNCSGCLGVGDIQSTIEPRRLDSLTGKKIASL--SYGSGPHIVLATTDGEVF 121

Query: 713  SWGDGDYGKLGHGNSDRQRRPRQIEA-LQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDY 889
            +WG   Y +LG+G ++    P  I   L  ++V++++CG  HS V+TSDG++F +G  + 
Sbjct: 122  TWGHNAYSQLGNGTTNHGLVPCHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWGYNNS 181

Query: 890  GRLGLGNTSNKKLPERVTA-LEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLG 1066
            G++G G+T+N+ +P RVT  L+   +  +ACG   ++AV  D   V+ +G    G+LGLG
Sbjct: 182  GQVGSGSTANQPIPRRVTGCLQNKVVMNIACGQMCSMAV-VDTGEVYVWGYNGNGQLGLG 240

Query: 1067 NSTAKSSPQKVDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGLPEGRARNHNRP 1246
            +S  + +P +V  L GI +++VACG   ++ LT +G +Y +G +    L  G   N + P
Sbjct: 241  SSGNQPTPCRVAALQGIRVQRVACGYAHTLVLTDEGQIYAWGANSYGQLGTGNKSNQSYP 300

Query: 1247 QQIPVLAGVVIEDVAVGAEHTLALAST-GDVYAWGSNSEGQLGLGHTNH 1390
              + V    +IE  A  + HT A  +  G VY WG      + L H  H
Sbjct: 301  TPVVVEKDRIIEIAACHSAHTSAAKTQGGHVYMWGQCRGQSVILPHHTH 349



 Score =  151 bits (382), Expect = 3e-36
 Identities = 95/276 (34%), Positives = 154/276 (55%), Gaps = 4/276 (1%)
 Frame = +2

Query: 665  GSDGHSMALTE-SGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGF-KHS 838
            GS G+ +  T  + E+F  G    G LG G+      PR++++L G+++  +S G   H 
Sbjct: 52   GSAGNEVLYTTVNDEIFVLGTNCSGCLGVGDIQSTIEPRRLDSLTGKKIASLSYGSGPHI 111

Query: 839  AVVTSDGKLFTFGNGDYGRLGLGNTSNKKLPERV-TALEGYQIGQVACGLNHTLAVSADG 1015
             + T+DG++FT+G+  Y +LG G T++  +P  + T L   Q+ +VACG  H+L +++DG
Sbjct: 112  VLATTDGEVFTWGHNAYSQLGNGTTNHGLVPCHISTNLSNKQVIEVACGSYHSLVLTSDG 171

Query: 1016 SMVWAFGDGDYGKLGLGNSTAKSSPQKVD-VLCGIGIKKVACGTQFSVALTKDGHVYTFG 1192
              V+A+G  + G++G G++  +  P++V   L    +  +ACG   S+A+   G VY +G
Sbjct: 172  E-VFAWGYNNSGQVGSGSTANQPIPRRVTGCLQNKVVMNIACGQMCSMAVVDTGEVYVWG 230

Query: 1193 QDRLIGLPEGRARNHNRPQQIPVLAGVVIEDVAVGAEHTLALASTGDVYAWGSNSEGQLG 1372
             +    L  G + N   P ++  L G+ ++ VA G  HTL L   G +YAWG+NS GQLG
Sbjct: 231  YNGNGQLGLGSSGNQPTPCRVAALQGIRVQRVACGYAHTLVLTDEGQIYAWGANSYGQLG 290

Query: 1373 LGHTNHVREPTLVTVLQGKNVRQISAGRCHSAAWTA 1480
             G+ ++   PT V V   +  R I    CHSA  +A
Sbjct: 291  TGNKSNQSYPTPVVV---EKDRIIEIAACHSAHTSA 323



 Score =  113 bits (282), Expect = 1e-24
 Identities = 72/220 (32%), Positives = 113/220 (51%), Gaps = 5/220 (2%)
 Frame = +2

Query: 392  DVYLWGAGRHGQLAEAGRNV-MVXXXXXXXXXXXXVI---CGQNCTFVIQANGTVLACGE 559
            +V+ WG   + QL     N  +V            VI   CG   + V+ ++G V A G 
Sbjct: 119  EVFTWGHNAYSQLGNGTTNHGLVPCHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWGY 178

Query: 560  GSYGRLGQGNSDDLHV-LTVISALQGFVVTQLVTSCGSDGHSMALTESGEVFSWGDGDYG 736
             + G++G G++ +  +   V   LQ  VV  +  +CG    SMA+ ++GEV+ WG    G
Sbjct: 179  NNSGQVGSGSTANQPIPRRVTGCLQNKVVMNI--ACGQMC-SMAVVDTGEVYVWGYNGNG 235

Query: 737  KLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLGLGNTS 916
            +LG G+S  Q  P ++ ALQG  V +++CG+ H+ V+T +G+++ +G   YG+LG GN S
Sbjct: 236  QLGLGSSGNQPTPCRVAALQGIRVQRVACGYAHTLVLTDEGQIYAWGANSYGQLGTGNKS 295

Query: 917  NKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFG 1036
            N+  P  V   +   I   AC   HT A    G  V+ +G
Sbjct: 296  NQSYPTPVVVEKDRIIEIAACHSAHTSAAKTQGGHVYMWG 335


>ref|NP_082040.2| RCC1 and BTB domain-containing protein 1 [Mus musculus].
          Length = 531

 Score =  145 bits (366), Expect = 2e-34
 Identities = 93/295 (31%), Positives = 160/295 (54%), Gaps = 3/295 (1%)
 Frame = +2

Query: 605  VLTVISALQGFVVTQLVTSCGSDGHSMALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQI 784
            + T++S  +   + +      S   ++ +T++ EVF +G      LG G++     P+++
Sbjct: 9    IFTLLSPQEAGSIRKACVFGTSANEAIYVTDNDEVFVFGLNYSNCLGTGDNQSTLVPKKL 68

Query: 785  EALQGEEVVQMSCGF-KHSAVVTSDGKLFTFGNGDYGRLGLGNTSNKKLPERV-TALEGY 958
            EAL G+++  +S G   H  + T DG ++ +G+  Y +LG G T+    P +V T L   
Sbjct: 69   EALCGKKIKSLSYGSGPHVLLTTEDGVVYAWGHNGYSQLGNGTTNQGIAPVQVCTNLLIK 128

Query: 959  QIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNSTAKSSPQKV-DVLCGIGIKKVA 1135
            Q+ +VACG +H++A++ADG + +A+G  + G++G G++  + +P+KV + L    +  +A
Sbjct: 129  QVIEVACGSHHSMALAADGEL-FAWGYNNCGQVGSGSTANQPTPRKVTNCLHTKRVVNIA 187

Query: 1136 CGTQFSVALTKDGHVYTFGQDRLIGLPEGRARNHNRPQQIPVLAGVVIEDVAVGAEHTLA 1315
            CG   S+A+   G VY +G +    L  G   N   P ++  L G+ +  +  G  HTLA
Sbjct: 188  CGQTSSMAVLDSGEVYGWGYNGNGQLGLGNNGNQLTPVRVAALHGMCVNQIVCGYAHTLA 247

Query: 1316 LASTGDVYAWGSNSEGQLGLGHTNHVREPTLVTVLQGKNVRQISAGRCHSAAWTA 1480
            L   G +YAWG+N+ GQLG G  N++  PT + V   +  R I    CHS   +A
Sbjct: 248  LTDEGLLYAWGANTYGQLGTGSKNNLLSPTQIMV---EKERVIEIAACHSTHTSA 299



 Score =  145 bits (365), Expect = 3e-34
 Identities = 96/297 (32%), Positives = 152/297 (51%), Gaps = 3/297 (1%)
 Frame = +2

Query: 509  NCTFVIQANGTVLACGEGSYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSDGHSMA 688
            N    +  N  V   G      LG G++    V   + AL G  +  L  S GS  H + 
Sbjct: 32   NEAIYVTDNDEVFVFGLNYSNCLGTGDNQSTLVPKKLEALCGKKIKSL--SYGSGPHVLL 89

Query: 689  LTESGEVFSWGDGDYGKLGHGNSDRQRRPRQI-EALQGEEVVQMSCGFKHSAVVTSDGKL 865
             TE G V++WG   Y +LG+G +++   P Q+   L  ++V++++CG  HS  + +DG+L
Sbjct: 90   TTEDGVVYAWGHNGYSQLGNGTTNQGIAPVQVCTNLLIKQVIEVACGSHHSMALAADGEL 149

Query: 866  FTFGNGDYGRLGLGNTSNKKLPERVT-ALEGYQIGQVACGLNHTLAVSADGSMVWAFGDG 1042
            F +G  + G++G G+T+N+  P +VT  L   ++  +ACG   ++AV  D   V+ +G  
Sbjct: 150  FAWGYNNCGQVGSGSTANQPTPRKVTNCLHTKRVVNIACGQTSSMAV-LDSGEVYGWGYN 208

Query: 1043 DYGKLGLGNSTAKSSPQKVDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGLPEG 1222
              G+LGLGN+  + +P +V  L G+ + ++ CG   ++ALT +G +Y +G +    L  G
Sbjct: 209  GNGQLGLGNNGNQLTPVRVAALHGMCVNQIVCGYAHTLALTDEGLLYAWGANTYGQLGTG 268

Query: 1223 RARNHNRPQQIPVLAGVVIEDVAVGAEHTLALAST-GDVYAWGSNSEGQLGLGHTNH 1390
               N   P QI V    VIE  A  + HT A  +  G VY WG      + L H  H
Sbjct: 269  SKNNLLSPTQIMVEKERVIEIAACHSTHTSAAKTQGGHVYMWGQCRGQSVILPHLTH 325



 Score =  102 bits (254), Expect = 2e-21
 Identities = 66/219 (30%), Positives = 104/219 (47%), Gaps = 5/219 (2%)
 Frame = +2

Query: 395  VYLWGAGRHGQLAEAGRNVMVXXXXXXXXXXXX----VICGQNCTFVIQANGTVLACGEG 562
            VY WG   + QL     N  +                V CG + +  + A+G + A G  
Sbjct: 96   VYAWGHNGYSQLGNGTTNQGIAPVQVCTNLLIKQVIEVACGSHHSMALAADGELFAWGYN 155

Query: 563  SYGRLGQGNSDDLHV-LTVISALQGFVVTQLVTSCGSDGHSMALTESGEVFSWGDGDYGK 739
            + G++G G++ +      V + L    V  +  +CG    SMA+ +SGEV+ WG    G+
Sbjct: 156  NCGQVGSGSTANQPTPRKVTNCLHTKRVVNI--ACGQTS-SMAVLDSGEVYGWGYNGNGQ 212

Query: 740  LGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLGLGNTSN 919
            LG GN+  Q  P ++ AL G  V Q+ CG+ H+  +T +G L+ +G   YG+LG G+ +N
Sbjct: 213  LGLGNNGNQLTPVRVAALHGMCVNQIVCGYAHTLALTDEGLLYAWGANTYGQLGTGSKNN 272

Query: 920  KKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFG 1036
               P ++   +   I   AC   HT A    G  V+ +G
Sbjct: 273  LLSPTQIMVEKERVIEIAACHSTHTSAAKTQGGHVYMWG 311


  Database: RefSeq49_MP.fasta
    Posted date:  Oct 17, 2011  1:42 PM
  Number of letters in database: 15,617,559
  Number of sequences in database:  30,036
  
Lambda     K      H
   0.318    0.134    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 30036
Number of Hits to DB: 117,641,401
Number of extensions: 3111221
Number of successful extensions: 11054
Number of sequences better than 1.0e-05: 57
Number of HSP's gapped: 10359
Number of HSP's successfully gapped: 166
Length of query: 1168
Length of database: 15,617,559
Length adjustment: 112
Effective length of query: 1056
Effective length of database: 12,253,527
Effective search space: 12939724512
Effective search space used: 12939724512
Neighboring words threshold: 12
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 36 (18.5 bits)

BLASTX 2.2.24 [Aug-08-2010]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= 20110601C-003115
         (3506 letters)

Database: RefSeq49_SP.fasta 
           24,897 sequences; 11,343,932 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

Alignment   gi|XP_001927286.3| PREDICTED: probable E3 ubiquitin-protein lig...  1977   0.0  
Alignment   gi|XP_003361480.1| PREDICTED: probable E3 ubiquitin-protein lig...  1974   0.0  
Alignment   gi|XP_003133446.2| PREDICTED: e3 ubiquitin-protein ligase HERC2...   639   0.0  
Alignment   gi|XP_003128098.1| PREDICTED: e3 ubiquitin-protein ligase HECTD...   191   3e-48
Alignment   gi|XP_003129377.2| PREDICTED: probable E3 ubiquitin-protein lig...   176   8e-44
Alignment   gi|XP_003129374.2| PREDICTED: probable E3 ubiquitin-protein lig...   165   2e-40
Alignment   gi|XP_001928937.1| PREDICTED: RCC1 and BTB domain-containing pr...   151   2e-36
Alignment   gi|XP_003135065.2| PREDICTED: hypothetical protein LOC100511730...   144   4e-34
Alignment   gi|XP_003357882.1| PREDICTED: RCC1 and BTB domain-containing pr...   143   6e-34
Alignment   gi|XP_001924648.3| PREDICTED: probable E3 ubiquitin-protein lig...   142   1e-33

>ref|XP_001927286.3| PREDICTED: probable E3 ubiquitin-protein ligase HERC1 [Sus scrofa].
          Length = 4807

 Score = 1977 bits (5123), Expect = 0.0
 Identities = 970/994 (97%), Positives = 970/994 (97%)
 Frame = +2

Query: 2    EKPHVVCGDQLVHSPYMQCLASLAVGLHLDQLLCNPPVPPHHQNCLPDPASWNPNEWAWL 181
            EKPHVVCGDQLVHSPYMQCLASLAVGLHLDQLLCNPPVPPHHQNCLPDPASWNPNEWAWL
Sbjct: 3814 EKPHVVCGDQLVHSPYMQCLASLAVGLHLDQLLCNPPVPPHHQNCLPDPASWNPNEWAWL 3873

Query: 182  ECFSTTIKAAEALTNGAQFPESFSVPDLEPVPEDELVFLMDNSKWINGMDEQIMSWATSR 361
            ECFSTTIKAAEALTNGAQFPESFSVPDLEPVPEDELVFLMDNSKWINGMDEQIMSWATSR
Sbjct: 3874 ECFSTTIKAAEALTNGAQFPESFSVPDLEPVPEDELVFLMDNSKWINGMDEQIMSWATSR 3933

Query: 362  PEDWHLGGKCDVYLWGAGRHGQLAEAGRNVMVXXXXXXXXXXXXVICGQNCTFVIQANGT 541
            PEDWHLGGKCDVYLWGAGRHGQLAEAGRNVMV            VICGQNCTFVIQANGT
Sbjct: 3934 PEDWHLGGKCDVYLWGAGRHGQLAEAGRNVMVPAAAPSFSQAQQVICGQNCTFVIQANGT 3993

Query: 542  VLACGEGSYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSDGHSMALTESGEVFSWG 721
            VLACGEGSYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSDGHSMALTESGEVFSWG
Sbjct: 3994 VLACGEGSYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSDGHSMALTESGEVFSWG 4053

Query: 722  DGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLG 901
            DGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLG
Sbjct: 4054 DGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLG 4113

Query: 902  LGNTSNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNSTAK 1081
            LGNTSNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNSTAK
Sbjct: 4114 LGNTSNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNSTAK 4173

Query: 1082 SSPQKVDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGLPEGRARNHNRPQQIPV 1261
            SSPQKVDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGLPEGRARNHNRPQQIPV
Sbjct: 4174 SSPQKVDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGLPEGRARNHNRPQQIPV 4233

Query: 1262 LAGVVIEDVAVGAEHTLALASTGDVYAWGSNSEGQLGLGHTNHVREPTLVTVLQGKNVRQ 1441
            LAGVVIEDVAVGAEHTLALASTGDVYAWGSNSEGQLGLGHTNHVREPTLVTVLQGKNVRQ
Sbjct: 4234 LAGVVIEDVAVGAEHTLALASTGDVYAWGSNSEGQLGLGHTNHVREPTLVTVLQGKNVRQ 4293

Query: 1442 ISAGRCHSAAWTAPPVPPRAPGVSVPLQLGLPDAVPPQYGALREVSIHTARARLRLLYHF 1621
            ISAGRCHSAAWTAPPVPPRAPGVSVPLQLGLPDAVPPQYGALREVSIHTARARLRLLYHF
Sbjct: 4294 ISAGRCHSAAWTAPPVPPRAPGVSVPLQLGLPDAVPPQYGALREVSIHTARARLRLLYHF 4353

Query: 1622 SDLMYSSWRLLNLSPNNQNSTSHYNAGTWGIVQGQLRPLLAPRVYTLPMVRSIGKTMVQG 1801
            SDLMYSSWRLLNLSPNNQNSTSHYNAGTWGIVQGQLRPLLAPRVYTLPMVRSIGKTMVQG
Sbjct: 4354 SDLMYSSWRLLNLSPNNQNSTSHYNAGTWGIVQGQLRPLLAPRVYTLPMVRSIGKTMVQG 4413

Query: 1802 KNYGPQITVKRISTRGRKCKPIFVQIARQVVKLNASDLRLPSRAWKVKLVGEGADDAGGV 1981
            KNYGPQITVKRISTRGRKCKPIFVQIARQVVKLNASDLRLPSRAWKVKLVGEGADDAGGV
Sbjct: 4414 KNYGPQITVKRISTRGRKCKPIFVQIARQVVKLNASDLRLPSRAWKVKLVGEGADDAGGV 4473

Query: 1982 FDDTITEMCQELETGIVDLLIPSPNATAEVGYNRDRFLFNPSACLDEHLMQFKFLGILMG 2161
            FDDTITEMCQELETGIVDLLIPSPNATAEVGYNRDRFLFNPSACLDEHLMQFKFLGILMG
Sbjct: 4474 FDDTITEMCQELETGIVDLLIPSPNATAEVGYNRDRFLFNPSACLDEHLMQFKFLGILMG 4533

Query: 2162 VAIRTKKPLDLHLAPLVWKQLCCVPXXXXXXXXXXXXYVQTLNSILHIEDSGITEESFHE 2341
            VAIRTKKPLDLHLAPLVWKQLCCVP            YVQTLNSILHIEDSGITEESFHE
Sbjct: 4534 VAIRTKKPLDLHLAPLVWKQLCCVPLTLEDLEEVDLLYVQTLNSILHIEDSGITEESFHE 4593

Query: 2342 MIPLDSFVGQSADGKMVPIIPGGNSIPLTFSNRKEYVERAIEYRLHEMDRQVAAVREGMS 2521
            MIPLDSFVGQSADGKMVPIIPGGNSIPLTFSNRKEYVERAIEYRLHEMDRQVAAVREGMS
Sbjct: 4594 MIPLDSFVGQSADGKMVPIIPGGNSIPLTFSNRKEYVERAIEYRLHEMDRQVAAVREGMS 4653

Query: 2522 WIVPVPLLSLLTAKQLEQMVCGMPEISVEVLKKVVRYREVDEQHQLVQWFWHTLEEFSNE 2701
            WIVPVPLLSLLTAKQLEQMVCGMPEISVEVLKKVVRYREVDEQHQLVQWFWHTLEEFSNE
Sbjct: 4654 WIVPVPLLSLLTAKQLEQMVCGMPEISVEVLKKVVRYREVDEQHQLVQWFWHTLEEFSNE 4713

Query: 2702 ERVLFMRFVSGRSRLPANTADISQRFQIMKVDRPYDSLPTSQTCFFQLRLPPYSSQLVMA 2881
            ERVLFMRFVSGRSRLPANTADISQRFQIMKVDRPYDSLPTSQTCFFQLRLPPYSSQLVMA
Sbjct: 4714 ERVLFMRFVSGRSRLPANTADISQRFQIMKVDRPYDSLPTSQTCFFQLRLPPYSSQLVMA 4773

Query: 2882 ERLRYAINNCRSIDMDNYMLSRNVDNAEGSDTDY 2983
            ERLRYAINNCRSIDMDNYMLSRNVDNAEGSDTDY
Sbjct: 4774 ERLRYAINNCRSIDMDNYMLSRNVDNAEGSDTDY 4807



 Score =  314 bits (805), Expect = 2e-85
 Identities = 166/369 (44%), Positives = 235/369 (63%), Gaps = 3/369 (0%)
 Frame = +2

Query: 389  CDVYLWGAGRHGQLAEAGRNVMVXXXXXXXXXXXXVI-CGQNCTFVIQANGTVLACGEGS 565
            C+VY+WG+    QL E  +  ++             I  GQ CTFVI  +G+V ACG+GS
Sbjct: 372  CEVYVWGSNSSHQLVEGTQEKILQPKLAPSFSDAQTIEAGQYCTFVISTDGSVRACGKGS 431

Query: 566  YGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSDGHSMALTESGEVFSWGDGDYGKLG 745
            YGRLG G+S++   L  ++      + ++ +S GSDGH++A T  GEVFSWGDGDYGKLG
Sbjct: 432  YGRLGLGDSNNQSTLKKLTFEPHRSIKKVSSSKGSDGHTLAFTTEGEVFSWGDGDYGKLG 491

Query: 746  HGNSDRQRRPRQIEA-LQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLGLGNTSNK 922
            HGNS  Q+ P+ I+  LQG+ VV +S G++HSA VT DG+L+T+G GD+GRLG G+++++
Sbjct: 492  HGNSSTQKYPKLIQGPLQGKVVVCVSAGYRHSAAVTEDGELYTWGEGDFGRLGHGDSNSR 551

Query: 923  KLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNSTAKSSPQKVD 1102
             +P  V  +    +G+V+CG +HT+A+S DG  VW+FG GD GKLG G++     P+ ++
Sbjct: 552  NIPTLVKDIS--NVGEVSCGSSHTIALSKDGRTVWSFGGGDNGKLGHGDTNRVYKPKVIE 609

Query: 1103 VLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGLPEGRARNHNRPQQIPVLAGVVIE 1282
             L G+ I+KV  G+Q S+ALT  G VY +G    +G     A    RP+ I  LA   I 
Sbjct: 610  ALQGMFIRKVCAGSQSSLALTSTGQVYAWGCGACLGCGSSEA-TALRPKLIEELAATRIV 668

Query: 1283 DVAVGAEHTLALASTGDVYAWGSNSEGQLGLGH-TNHVREPTLVTVLQGKNVRQISAGRC 1459
            D+++G  H LAL+   +VYAWG+NS GQ G G+ T  + +P  V+ L G  ++QISAG  
Sbjct: 669  DISIGDSHCLALSHDNEVYAWGNNSMGQCGQGNSTGPITKPKKVSGLDGIAIQQISAGTS 728

Query: 1460 HSAAWTAPP 1486
            HS AWTA P
Sbjct: 729  HSLAWTALP 737


>ref|XP_003361480.1| PREDICTED: probable E3 ubiquitin-protein ligase HERC1-like, partial
            [Sus scrofa].
          Length = 2771

 Score = 1974 bits (5113), Expect = 0.0
 Identities = 968/994 (97%), Positives = 968/994 (97%)
 Frame = +2

Query: 2    EKPHVVCGDQLVHSPYMQCLASLAVGLHLDQLLCNPPVPPHHQNCLPDPASWNPNEWAWL 181
            EKPHVVCGDQLVHSPYMQCLASLAVGLHLDQLLCNPPVPPHHQNCLPDPASWNPNEWAWL
Sbjct: 1778 EKPHVVCGDQLVHSPYMQCLASLAVGLHLDQLLCNPPVPPHHQNCLPDPASWNPNEWAWL 1837

Query: 182  ECFSTTIKAAEALTNGAQFPESFSVPDLEPVPEDELVFLMDNSKWINGMDEQIMSWATSR 361
            ECFSTTIKAAEALTNGAQFPESFSVPDLEPVPEDELVFLMDNSKWINGMDEQIMSWATSR
Sbjct: 1838 ECFSTTIKAAEALTNGAQFPESFSVPDLEPVPEDELVFLMDNSKWINGMDEQIMSWATSR 1897

Query: 362  PEDWHLGGKCDVYLWGAGRHGQLAEAGRNVMVXXXXXXXXXXXXVICGQNCTFVIQANGT 541
            PEDWHLGGKCDVYLWGAGRHGQLAEAGRNVMV            VICGQNCTFVIQANGT
Sbjct: 1898 PEDWHLGGKCDVYLWGAGRHGQLAEAGRNVMVPAAAPSFSQAQQVICGQNCTFVIQANGT 1957

Query: 542  VLACGEGSYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSDGHSMALTESGEVFSWG 721
            VLACGEGSYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSDGHSMALTESGEVFSWG
Sbjct: 1958 VLACGEGSYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSDGHSMALTESGEVFSWG 2017

Query: 722  DGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLG 901
            DGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLG
Sbjct: 2018 DGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLG 2077

Query: 902  LGNTSNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNSTAK 1081
            LGNTSNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNSTAK
Sbjct: 2078 LGNTSNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNSTAK 2137

Query: 1082 SSPQKVDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGLPEGRARNHNRPQQIPV 1261
            SSPQKVDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGLPEGRARNHNRPQQIPV
Sbjct: 2138 SSPQKVDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGLPEGRARNHNRPQQIPV 2197

Query: 1262 LAGVVIEDVAVGAEHTLALASTGDVYAWGSNSEGQLGLGHTNHVREPTLVTVLQGKNVRQ 1441
            LAGVVIEDVAVGAEHTLALASTGDVYAWGSNSEGQLGLGHTNHVREPTLVTVLQGKNVRQ
Sbjct: 2198 LAGVVIEDVAVGAEHTLALASTGDVYAWGSNSEGQLGLGHTNHVREPTLVTVLQGKNVRQ 2257

Query: 1442 ISAGRCHSAAWTAPPVPPRAPGVSVPLQLGLPDAVPPQYGALREVSIHTARARLRLLYHF 1621
            ISAGRCHSAAWTAPPVPPRAPGVSVPLQLGLPDAVPPQYGALREVSIHTARARLRLLYHF
Sbjct: 2258 ISAGRCHSAAWTAPPVPPRAPGVSVPLQLGLPDAVPPQYGALREVSIHTARARLRLLYHF 2317

Query: 1622 SDLMYSSWRLLNLSPNNQNSTSHYNAGTWGIVQGQLRPLLAPRVYTLPMVRSIGKTMVQG 1801
            SDLMYSSWRLLNLSPNNQNSTSHYNAGTWGIVQGQLRPLLAPRVYTLPMVRSIGKTMVQG
Sbjct: 2318 SDLMYSSWRLLNLSPNNQNSTSHYNAGTWGIVQGQLRPLLAPRVYTLPMVRSIGKTMVQG 2377

Query: 1802 KNYGPQITVKRISTRGRKCKPIFVQIARQVVKLNASDLRLPSRAWKVKLVGEGADDAGGV 1981
            KNYGPQITVKRISTRGRKCKPIFVQIARQVVKLNASDLRLPSRAWKVKLVGEGADDAGGV
Sbjct: 2378 KNYGPQITVKRISTRGRKCKPIFVQIARQVVKLNASDLRLPSRAWKVKLVGEGADDAGGV 2437

Query: 1982 FDDTITEMCQELETGIVDLLIPSPNATAEVGYNRDRFLFNPSACLDEHLMQFKFLGILMG 2161
            FDDTITEMCQELETGIVDLLIPSPNATAEVGYNRDRFLFNPSACLDEHLMQFKFLGILMG
Sbjct: 2438 FDDTITEMCQELETGIVDLLIPSPNATAEVGYNRDRFLFNPSACLDEHLMQFKFLGILMG 2497

Query: 2162 VAIRTKKPLDLHLAPLVWKQLCCVPXXXXXXXXXXXXYVQTLNSILHIEDSGITEESFHE 2341
            VAIRTKKPLDLHLAPLVWKQLCCVP            YVQTLNSILHIEDSGITEESFHE
Sbjct: 2498 VAIRTKKPLDLHLAPLVWKQLCCVPLTLEDLEEVDLLYVQTLNSILHIEDSGITEESFHE 2557

Query: 2342 MIPLDSFVGQSADGKMVPIIPGGNSIPLTFSNRKEYVERAIEYRLHEMDRQVAAVREGMS 2521
            MIPLDSFVGQSADGKMVPIIPGGNSIPLTFSNRKEYVERAIEYRLHEMDRQVAAVREGMS
Sbjct: 2558 MIPLDSFVGQSADGKMVPIIPGGNSIPLTFSNRKEYVERAIEYRLHEMDRQVAAVREGMS 2617

Query: 2522 WIVPVPLLSLLTAKQLEQMVCGMPEISVEVLKKVVRYREVDEQHQLVQWFWHTLEEFSNE 2701
            WIVPVPLLSLLTAKQLEQMVCGMPEISVEVLKKVVRYREVDEQHQLVQWFWHTLEEFSNE
Sbjct: 2618 WIVPVPLLSLLTAKQLEQMVCGMPEISVEVLKKVVRYREVDEQHQLVQWFWHTLEEFSNE 2677

Query: 2702 ERVLFMRFVSGRSRLPANTADISQRFQIMKVDRPYDSLPTSQTCFFQLRLPPYSSQLVMA 2881
            ERVLFMRFVSGRSRLPANTADISQRFQIMKVDRPYDSLPTSQTCFFQLRLPPYSSQLVMA
Sbjct: 2678 ERVLFMRFVSGRSRLPANTADISQRFQIMKVDRPYDSLPTSQTCFFQLRLPPYSSQLVMA 2737

Query: 2882 ERLRYAINNCRSIDMDNYMLSRNVDNAEGSDTDY 2983
            ERLRYAINNC  IDMDNYMLSRNVDNAEGSDTDY
Sbjct: 2738 ERLRYAINNCHPIDMDNYMLSRNVDNAEGSDTDY 2771


>ref|XP_003133446.2| PREDICTED: e3 ubiquitin-protein ligase HERC2-like [Sus scrofa].
          Length = 4292

 Score =  639 bits (1649), Expect = 0.0
 Identities = 390/1007 (38%), Positives = 544/1007 (54%), Gaps = 29/1007 (2%)
 Frame = +2

Query: 2    EKPHVVCGDQLVHSPYMQCLASLAVGLHLDQLLCNPPVPPHHQNCLPDPASWNPNEWAWL 181
            E P V  G QL+HSP+ + L +LA  L LD L C          C         ++WAW 
Sbjct: 3290 EDPIVRGGKQLLHSPFFKVLVALACDLELDTLPC----------CA------ETHKWAWF 3333

Query: 182  ECFSTTIKAAEALTNGAQFPESF------SVPDLEPVPEDELVFLMDNSKWINGMDEQIM 343
              +    + A AL      P  F       + +L    E+  V    +  +    DEQ++
Sbjct: 3334 RRYCMASRVAVALDKRTPLPRLFLDEVAKKIRELMADGENMDVLHESHDIFRREQDEQLV 3393

Query: 344  SWATSRPEDWHL--GGKCDVYLWGAGRHGQLAEA-GRNVMVXXXXXXXXXXXXV--ICGQ 508
             W   RP+DW L  GG   +Y WG    GQL    G  V V            V  I G+
Sbjct: 3394 QWMNRRPDDWTLSAGGSGTIYGWGHNHRGQLGGIEGAKVKVPTPCEALAALRPVQLIGGE 3453

Query: 509  NCTFVIQANGTVLACGEGSYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSDGHSMA 688
               F + A+G + A G G+ GRLG G ++ +   T++ ++Q   + ++  + G   H +A
Sbjct: 3454 QTLFAVTADGKLYATGYGAGGRLGIGGTESVSTPTLLESIQHVFIKKVAVNSGGK-HCLA 3512

Query: 689  LTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLF 868
            L+  GEV+SWG+ + GKLGHGN     RPR IE+L+G EVV ++ G  HSA VT+ G L+
Sbjct: 3513 LSSEGEVYSWGEAEDGKLGHGNRSPCDRPRVIESLRGIEVVDVAAGGAHSACVTAAGDLY 3572

Query: 869  TFGNGDYGRLGLGNTSNKKLPERVTALEGYQIGQVACGLN--HTLAVSADGSMVWAFGDG 1042
            T+G G YGRLG  ++ ++  P+ V AL+G+++  VACG     TL ++ D + VW++GDG
Sbjct: 3573 TWGKGRYGRLGHSDSEDQLKPKLVDALQGHRVVDVACGSGDAQTLCLTDDDT-VWSWGDG 3631

Query: 1043 DYGKLGLGNSTAKSSPQKVDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGLPEG 1222
            DYGKLG G S     P K+D L G+G+ KV CG+QFSVALTK G VYT+G+     L  G
Sbjct: 3632 DYGKLGRGGSDGCKVPMKIDSLTGLGVVKVECGSQFSVALTKSGAVYTWGKGDYHRLGHG 3691

Query: 1223 RARNHNRPQQIPVLAGVVIEDVAVGAEHTLALASTGDVYAWGSNSEGQLGLGHTNHVREP 1402
               +  RP+Q+  L G  +  +A G+ H +     G  Y WG N EGQLG G TN ++ P
Sbjct: 3692 SDDHVRRPRQVQGLQGKKVIAIATGSLHCVCCTEDGS-YTWGDNDEGQLGDGTTNAIQRP 3750

Query: 1403 TLVTVLQGKNVRQISAGRCHSAAWTAPPVPPRAPGVSVPLQLG-LPDAVPPQYGALREVS 1579
             LV  LQGK V +++ G  H+ AW+           S P   G LP  VP +Y  L+E+ 
Sbjct: 3751 RLVAALQGKKVNRVACGSAHTLAWST----------SKPASAGKLPAQVPMEYNHLQEIP 3800

Query: 1580 IHTARARLRLLYHFSDLMYSSWRLLNLSPNNQNSTSHYNAGTWGIVQGQLRPLLAPRVYT 1759
            I   R RL LL+H S+L      + +L  +   +    + G        LR +L  +   
Sbjct: 3801 IIALRNRLLLLHHISELFCPCIPMFDLEGSLDETGLGPSVGF-----DTLRGILISQGKE 3855

Query: 1760 LPMVRSIGKTMVQGKNYGPQITVKRISTRGRKCK----------PIFVQIARQVVKLNAS 1909
                + +  TMV+ + +GP + + RI  +  + K           +F Q+  ++   +  
Sbjct: 3856 AAFRKVVQATMVRDRQHGPVVELNRIQVKRSRSKGGLAGPDGTKSVFGQMCAKMSSFSPD 3915

Query: 1910 DLRLPSRAWKVKLVGEGADDAGGVFDDTITEMCQELETGIVDLLIPSPNATAEVGYNRDR 2089
             L LP R WKVK VGE  DD GG + ++I E+C+EL+ G+  LLI +PN   E G NRD 
Sbjct: 3916 SLLLPHRVWKVKFVGESVDDCGGGYSESIAEICEELQNGLTPLLIVTPNGRDESGANRDC 3975

Query: 2090 FLFNPSACLDEHLMQFKFLGILMGVAIRTKKPLDLHLAPLVWKQLCCVPXXXXXXXXXXX 2269
            +LF+P+A    H   F+FLG+L+G+AIRT  PL L+LA  VWKQL  +            
Sbjct: 3976 YLFSPAARAPVHTNMFRFLGVLLGIAIRTGSPLSLNLAEPVWKQLAGMSLTIADLSEVDK 4035

Query: 2270 XYVQTLNSILHIEDSGITEESFHEM-IPLDSFVGQSADGKMVPIIPGGNSIPLTFSNRKE 2446
             ++  L   ++I D+  T E F  M +P   F   SA G+ + +        +T  NR E
Sbjct: 4036 DFIPGL---MYIRDNEATSEEFEAMSLP---FTVPSASGQDIQL--SSKYTHITLDNRAE 4087

Query: 2447 YVERAIEYRLHEMDRQVAAVREGMSWIVPVPLLSLLTAKQLEQMVCGMPEISVEVLKKVV 2626
            YV  AI YRLHE D QVAAVREGM+ +VPVPLLSL T  +LE MVCG P+I + +LK V 
Sbjct: 4088 YVRLAINYRLHEFDEQVAAVREGMARVVPVPLLSLFTGYELETMVCGSPDIPLHLLKSVA 4147

Query: 2627 RYREVDEQHQLVQWFWHTLEEFSNEERVLFMRFVSGRSRLPANTADISQR-FQIMKVDR- 2800
             Y+ V+    L+QWFW  +E FSN ER LF+RFV GR+RLP   AD   R F I  +D+ 
Sbjct: 4148 TYKGVEPSASLIQWFWEVMESFSNTERSLFLRFVWGRTRLPRTIADFRGRDFVIQVLDKY 4207

Query: 2801 --PYDSLPTSQTCFFQLRLPPYSSQLVMAERLRYAINNCRSIDMDNY 2935
              P   LP S TCFF L+LP YS + V+ E+L+YAI+ C+SID D+Y
Sbjct: 4208 NPPDHFLPESYTCFFLLKLPRYSCKQVLEEKLKYAIHFCKSIDTDDY 4254



 Score =  263 bits (672), Expect = 5e-70
 Identities = 147/343 (42%), Positives = 208/343 (60%), Gaps = 3/343 (0%)
 Frame = +2

Query: 503  GQNCTFVIQANGTVLACGEGSYGRLGQG-NSDDLHVLTVISALQGFVVTQLVTSCGSDGH 679
            G    F +   G V ACGE + GRLG G +S  + +   I+AL  +VV ++    G   H
Sbjct: 2457 GSKSLFAVTVEGKVYACGEATNGRLGLGISSGTVPIPRQITALSSYVVKKVAVHSGGR-H 2515

Query: 680  SMALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDG 859
            + ALT  G+VFSWG+GD GKLGH +     +PR IEAL+ + +  ++CG  HSA +TS G
Sbjct: 2516 ATALTVDGKVFSWGEGDDGKLGHFSRMNCDKPRLIEALKTKRIRDIACGSSHSAALTSSG 2575

Query: 860  KLFTFGNGDYGRLGLGNTSNKKLPERVTALEGYQIGQVACGLN--HTLAVSADGSMVWAF 1033
            +L+T+G G+YGRLG G+ + +  P+ V  L G+++ QVACG     TLA++ +G +V+++
Sbjct: 2576 ELYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEG-LVFSW 2634

Query: 1034 GDGDYGKLGLGNSTAKSSPQKVDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGL 1213
            GDGD+GKLG G S   + PQ ++ L G G+ ++ CG QFS+ALTK G V+T+G+     L
Sbjct: 2635 GDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFSLALTKSGVVWTWGKGDYFRL 2694

Query: 1214 PEGRARNHNRPQQIPVLAGVVIEDVAVGAEHTLALASTGDVYAWGSNSEGQLGLGHTNHV 1393
              G   +  +PQ +  L G  I  VAVGA H LA+   G VYAWG N  GQ G G T   
Sbjct: 2695 GHGSDVHVRKPQVVEGLRGKKIVHVAVGALHCLAVTDAGQVYAWGDNDHGQQGNGTTTVN 2754

Query: 1394 REPTLVTVLQGKNVRQISAGRCHSAAWTAPPVPPRAPGVSVPL 1522
            R+PTLV  L+G+ + +++ G  HS AWT   V    P V  P+
Sbjct: 2755 RKPTLVQGLEGQKITRVACGSSHSVAWTT--VDVATPSVHEPV 2795



 Score =  204 bits (518), Expect = 4e-52
 Identities = 126/339 (37%), Positives = 191/339 (56%), Gaps = 20/339 (5%)
 Frame = +2

Query: 512  CTFVIQANGTVLACGEGSYGRLGQG--------NSDDLHVLTVISALQGFVVTQLVT-SC 664
            C  +     T +AC E  +  L +         NSD L    V    QG     ++  + 
Sbjct: 446  CEGLANLGVTQIACAEKRFLILSRNGRVYTQAYNSDTLAPQLV----QGLASRNIIKIAA 501

Query: 665  GSDGHS-MALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEE----VVQMSCGF 829
             SDGH  +AL  +GEV+SWG GD G+LGHG++     P+ I A  G++    VV ++CG 
Sbjct: 502  HSDGHHYLALAATGEVYSWGCGDGGRLGHGDTVPLEEPKVISAFSGKQAGKHVVHIACGS 561

Query: 830  KHSAVVTSDGKLFTFGNGDYGRLGLGNTSNKKLPERVTALEGYQIGQVACGLN--HTLAV 1003
             +SA +T++G+L+T+G G+YGRLG G++ ++ +P  V  L+G ++  VACG     TLAV
Sbjct: 562  TYSAAITAEGELYTWGRGNYGRLGHGSSEDEAIPMLVAGLKGLKVIDVACGSGDAQTLAV 621

Query: 1004 SADGSMVWAFGDGDYGKLGLGNSTAKSSPQKVDVLCGIGIKKVACGTQFSVALTKDGHVY 1183
            + +G  VW++GDGDYGKLG G S    +P+ ++ L  + + KV CG+QFS+ALTKDG VY
Sbjct: 622  TENGQ-VWSWGDGDYGKLGRGGSDGCKTPKLIEKLQDLDVVKVRCGSQFSIALTKDGQVY 680

Query: 1184 TFGQDRLIGLPEGRARNHNRPQQIPVLAGVVIEDVAVGAEHTLALASTGDVYAWGSNSEG 1363
            ++G+     L  G   +   P+ +  L G  + DVA G+ H LAL    +V++WGSN + 
Sbjct: 681  SWGKGDNQRLGHGTEEHVRYPKLLEGLQGKKVIDVAAGSTHCLALTEDSEVHSWGSNDQC 740

Query: 1364 QLGLGHTNHVR----EPTLVTVLQGKNVRQISAGRCHSA 1468
            Q    H + +R    EP+ +  L  K++  I+ G    A
Sbjct: 741  Q----HFDTLRVTKPEPSALPGLDTKHIVGIACGPAQKA 775



 Score =  166 bits (421), Expect = 6e-41
 Identities = 100/261 (38%), Positives = 142/261 (54%), Gaps = 4/261 (1%)
 Frame = +2

Query: 395  VYLWGAGRHGQLAEAGR---NVMVXXXXXXXXXXXXVICGQNCTFVIQANGTVLACGEGS 565
            V+ WG G  G+L    R   +               + CG + +  + ++G +   G G 
Sbjct: 2525 VFSWGEGDDGKLGHFSRMNCDKPRLIEALKTKRIRDIACGSSHSAALTSSGELYTWGLGE 2584

Query: 566  YGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGS-DGHSMALTESGEVFSWGDGDYGKL 742
            YGRLG G++       ++  L G  V Q+  +CGS D  ++ALT+ G VFSWGDGD+GKL
Sbjct: 2585 YGRLGHGDNTTQLKPKMVKVLLGHRVIQV--ACGSRDAQTLALTDEGLVFSWGDGDFGKL 2642

Query: 743  GHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLGLGNTSNK 922
            G G S+    P+ IE L G+ V Q+ CG + S  +T  G ++T+G GDY RLG G+  + 
Sbjct: 2643 GRGGSEGCNIPQNIERLNGQGVCQIECGAQFSLALTKSGVVWTWGKGDYFRLGHGSDVHV 2702

Query: 923  KLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNSTAKSSPQKVD 1102
            + P+ V  L G +I  VA G  H LAV+ D   V+A+GD D+G+ G G +T    P  V 
Sbjct: 2703 RKPQVVEGLRGKKIVHVAVGALHCLAVT-DAGQVYAWGDNDHGQQGNGTTTVNRKPTLVQ 2761

Query: 1103 VLCGIGIKKVACGTQFSVALT 1165
             L G  I +VACG+  SVA T
Sbjct: 2762 GLEGQKITRVACGSSHSVAWT 2782



 Score =  158 bits (399), Expect = 2e-38
 Identities = 115/393 (29%), Positives = 185/393 (47%), Gaps = 34/393 (8%)
 Frame = +2

Query: 65   SLAVGLHLDQLL--CNPPV---PPHHQNCLPDPASWNPNEWAW-------LECFS----- 193
            ++ V  HLD+L   C PP+   P  H+  L +   W    W +       ++C       
Sbjct: 394  AVVVMAHLDRLATPCMPPLCSSPTSHKGSLQEVIGWGLIGWKYYANVIGPIQCEGLANLG 453

Query: 194  -TTIKAAEAL-----TNGAQFPESFSVPDLEPVPEDELVFLMDNSKWINGMDEQIMSWAT 355
             T I  AE        NG  + ++++   L P             + + G+  + +    
Sbjct: 454  VTQIACAEKRFLILSRNGRVYTQAYNSDTLAP-------------QLVQGLASRNIIKIA 500

Query: 356  SRPEDWH---LGGKCDVYLWGAGRHGQLA-------EAGRNVMVXXXXXXXXXXXXVICG 505
            +  +  H   L    +VY WG G  G+L        E  + +              + CG
Sbjct: 501  AHSDGHHYLALAATGEVYSWGCGDGGRLGHGDTVPLEEPKVISAFSGKQAGKHVVHIACG 560

Query: 506  QNCTFVIQANGTVLACGEGSYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGS-DGHS 682
               +  I A G +   G G+YGRLG G+S+D  +  +++ L+G  V  +  +CGS D  +
Sbjct: 561  STYSAAITAEGELYTWGRGNYGRLGHGSSEDEAIPMLVAGLKGLKVIDV--ACGSGDAQT 618

Query: 683  MALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGK 862
            +A+TE+G+V+SWGDGDYGKLG G SD  + P+ IE LQ  +VV++ CG + S  +T DG+
Sbjct: 619  LAVTENGQVWSWGDGDYGKLGRGGSDGCKTPKLIEKLQDLDVVKVRCGSQFSIALTKDGQ 678

Query: 863  LFTFGNGDYGRLGLGNTSNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDG 1042
            ++++G GD  RLG G   + + P+ +  L+G ++  VA G  H LA++ D S V ++G  
Sbjct: 679  VYSWGKGDNQRLGHGTEEHVRYPKLLEGLQGKKVIDVAAGSTHCLALTED-SEVHSWGSN 737

Query: 1043 DYGKLGLGNSTAKSSPQKVDVLCGIGIKKVACG 1141
            D  +        K  P  +  L    I  +ACG
Sbjct: 738  DQCQHFDTLRVTKPEPSALPGLDTKHIVGIACG 770



 Score =  137 bits (345), Expect = 4e-32
 Identities = 94/269 (34%), Positives = 135/269 (50%), Gaps = 5/269 (1%)
 Frame = +2

Query: 686  ALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKL 865
            A T   +VF WG  D  +LG     + + P   E L    VVQ++ G K    VT +GK+
Sbjct: 2411 AATIRTKVFVWGLNDKDQLGGLKGSKIKVPSFSETLSALNVVQVAGGSKSLFAVTVEGKV 2470

Query: 866  FTFGNGDYGRLGLGNTSNK-KLPERVTALEGYQIGQVA--CGLNHTLAVSADGSMVWAFG 1036
            +  G    GRLGLG +S    +P ++TAL  Y + +VA   G  H  A++ DG  V+++G
Sbjct: 2471 YACGEATNGRLGLGISSGTVPIPRQITALSSYVVKKVAVHSGGRHATALTVDGK-VFSWG 2529

Query: 1037 DGDYGKLGLGNSTAKSSPQKVDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGLP 1216
            +GD GKLG  +      P+ ++ L    I+ +ACG+  S ALT  G +YT+G      L 
Sbjct: 2530 EGDDGKLGHFSRMNCDKPRLIEALKTKRIRDIACGSSHSAALTSSGELYTWGLGEYGRLG 2589

Query: 1217 EGRARNHNRPQQIPVLAGVVIEDVAVGAE--HTLALASTGDVYAWGSNSEGQLGLGHTNH 1390
             G      +P+ + VL G  +  VA G+    TLAL   G V++WG    G+LG G +  
Sbjct: 2590 HGDNTTQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFSWGDGDFGKLGRGGSEG 2649

Query: 1391 VREPTLVTVLQGKNVRQISAGRCHSAAWT 1477
               P  +  L G+ V QI  G   S A T
Sbjct: 2650 CNIPQNIERLNGQGVCQIECGAQFSLALT 2678



 Score =  130 bits (328), Expect = 4e-30
 Identities = 77/243 (31%), Positives = 136/243 (55%), Gaps = 8/243 (3%)
 Frame = +2

Query: 773  PRQIEALQGEEVVQMSCGFK--HSAVVTSDGKLFTFGNGDYGRLGLGNTSNKKLPERVTA 946
            P+ ++ L    +++++      H   + + G+++++G GD GRLG G+T   + P+ ++A
Sbjct: 485  PQLVQGLASRNIIKIAAHSDGHHYLALAATGEVYSWGCGDGGRLGHGDTVPLEEPKVISA 544

Query: 947  LEGYQIGQ----VACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNSTAKSSPQKVDVLCG 1114
              G Q G+    +ACG  ++ A++A+G + + +G G+YG+LG G+S  ++ P  V  L G
Sbjct: 545  FSGKQAGKHVVHIACGSTYSAAITAEGEL-YTWGRGNYGRLGHGSSEDEAIPMLVAGLKG 603

Query: 1115 IGIKKVACGT--QFSVALTKDGHVYTFGQDRLIGLPEGRARNHNRPQQIPVLAGVVIEDV 1288
            + +  VACG+    ++A+T++G V+++G      L  G +     P+ I  L  + +  V
Sbjct: 604  LKVIDVACGSGDAQTLAVTENGQVWSWGDGDYGKLGRGGSDGCKTPKLIEKLQDLDVVKV 663

Query: 1289 AVGAEHTLALASTGDVYAWGSNSEGQLGLGHTNHVREPTLVTVLQGKNVRQISAGRCHSA 1468
              G++ ++AL   G VY+WG     +LG G   HVR P L+  LQGK V  ++AG  H  
Sbjct: 664  RCGSQFSIALTKDGQVYSWGKGDNQRLGHGTEEHVRYPKLLEGLQGKKVIDVAAGSTHCL 723

Query: 1469 AWT 1477
            A T
Sbjct: 724  ALT 726



 Score = 68.2 bits (165), Expect = 3e-11
 Identities = 46/139 (33%), Positives = 73/139 (52%), Gaps = 8/139 (5%)
 Frame = +2

Query: 1088 PQKVDVLCGIGIKKVACGTQFSVALTKDGHVYT--FGQDRLIGLPEGRARNHNRPQQIPV 1261
            P + + L  +G+ ++AC  +  + L+++G VYT  +  D L             PQ +  
Sbjct: 443  PIQCEGLANLGVTQIACAEKRFLILSRNGRVYTQAYNSDTL------------APQLVQG 490

Query: 1262 LAGVVIEDVAVGAE--HTLALASTGDVYAWGSNSEGQLGLGHTNHVREPTLVTVLQ---- 1423
            LA   I  +A  ++  H LALA+TG+VY+WG    G+LG G T  + EP +++       
Sbjct: 491  LASRNIIKIAAHSDGHHYLALAATGEVYSWGCGDGGRLGHGDTVPLEEPKVISAFSGKQA 550

Query: 1424 GKNVRQISAGRCHSAAWTA 1480
            GK+V  I+ G  +SAA TA
Sbjct: 551  GKHVVHIACGSTYSAAITA 569


>ref|XP_003128098.1| PREDICTED: e3 ubiquitin-protein ligase HECTD3 [Sus scrofa].
          Length = 861

 Score =  191 bits (484), Expect = 3e-48
 Identities = 123/349 (35%), Positives = 182/349 (52%), Gaps = 9/349 (2%)
 Frame = +2

Query: 1910 DLRLPSRA---WKVKLVGEGADDAGGVFDDTITEMCQELETGIVDLLIPSP------NAT 2062
            D R P R    W+ K + EG  D GG F D++ +M +EL     D  +P P      N  
Sbjct: 517  DYRWPMRYDQWWECKFIAEGIIDQGGGFRDSLADMSEELCPSSADTPVPLPFFVRTANQG 576

Query: 2063 AEVGYNRDRFLFNPSACLDEHLMQFKFLGILMGVAIRTKKPLDLHLAPLVWKQLCCVPXX 2242
               G  RD ++ NPS C D    +++++G LMG A+R K+ L L L   VWKQL      
Sbjct: 577  NGTGEARDMYVPNPS-CRD--FAKYEWIGQLMGAALRGKEFLVLALPGFVWKQLSGEEVS 633

Query: 2243 XXXXXXXXXXYVQTLNSILHIEDSGITEESFHEMIPLDSFVGQSADGKMVPIIPGGNSIP 2422
                       +  L  ++   D    E  F + +   +F    +D ++V ++PGG  I 
Sbjct: 634  WSKDFPAVDSVLVKLLEVMEGMDKETFEFKFGKEL---TFTTVLSDQQVVELVPGGAGIV 690

Query: 2423 LTFSNRKEYVERAIEYRLHEMDRQVAAVREGMSWIVPVPLLSLLTAKQLEQMVCGMPEIS 2602
            + + +R  +V+   + RL E   QVAA++ G+  +VP  +L LLT ++LE+ VCG PE++
Sbjct: 691  VGYEDRSRFVQLVQKARLEESKEQVAAMQAGLLKVVPQAVLDLLTWQELEKKVCGDPEVT 750

Query: 2603 VEVLKKVVRYREVDEQHQLVQWFWHTLEEFSNEERVLFMRFVSGRSRLPANTADISQRFQ 2782
            V+ L+K+ R+ + +     VQ+FW  L  F+NE+R  F+RFV+GRSRLPA       +  
Sbjct: 751  VDALRKLTRFEDFEPSDTRVQYFWEALNNFTNEDRSRFLRFVTGRSRLPARIYIYPDKLG 810

Query: 2783 IMKVDRPYDSLPTSQTCFFQLRLPPYSSQLVMAERLRYAINNCRSIDMD 2929
                    D+LP S TC   L LP Y+S  V  E+LRYA  NC +ID D
Sbjct: 811  Y----ETTDALPESSTCSSTLFLPHYASAKVCEEKLRYAAYNCVAIDTD 855


>ref|XP_003129377.2| PREDICTED: probable E3 ubiquitin-protein ligase HERC3-like [Sus
            scrofa].
          Length = 370

 Score =  176 bits (446), Expect = 8e-44
 Identities = 113/330 (34%), Positives = 181/330 (54%), Gaps = 7/330 (2%)
 Frame = +2

Query: 494  VICGQNCTFVIQANGTVLACGEGSYGRLG---QGNSDDLHVLTVISALQGFVVTQLVTSC 664
            V CG + +  +  +G V  CG  + G+LG   +GN  +      I AL    +  +  +C
Sbjct: 39   VACGGDHSVFLLEDGEVYTCGLNTKGQLGHEREGNKPEQ-----IGALADEHIVHV--AC 91

Query: 665  GSDGHSMALTESGEVFSWGDGDYGKLGHGNSDRQRR-PRQIEALQGEEVVQMSCGFKHSA 841
            G + HS+AL++ G++FSWG G  G+LG   ++     PR I+ L  + ++Q+SCG  H  
Sbjct: 92   G-ESHSLALSDRGQLFSWGAGSDGQLGLMTTEESVAVPRLIQKLNQQTILQVSCGNWHCL 150

Query: 842  VVTSDGKLFTFGNGDYGRLGLGNT-SNKKLPERVTALEGYQIGQVACGLNHTLAVSADGS 1018
             + +DG+ FT+G   +G+LGLG    ++  P+RV +LEG  + QVA G  H+ A+S  G+
Sbjct: 151  ALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLSGA 210

Query: 1019 MVWAFGDGDYGKLGLGNSTAKSSPQKVDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQD 1198
             V+ +G  + G+LGL +   + SP  V +L    +  ++CG + +  LTK G V+TFG  
Sbjct: 211  -VFGWGMNNAGQLGLSDEEDRESPCHVKLLRAQKVVYISCGEEHTAVLTKSGGVFTFGAG 269

Query: 1199 RLIGLPEGRARNHNRPQQIPVLAGVVIEDVAVGAEHTLALA-STGDVYAWGSNSEGQLGL 1375
                L      +   P+++  L G  +  +A G +HTLA   S+G +YA+G  + GQLG 
Sbjct: 270  SCGQLGHDSMNDEVNPRRVLELMGSEVTQIACGRQHTLAFVPSSGLIYAFGCGARGQLGT 329

Query: 1376 GHTNHVREPTLVTVLQGKNVRQISA-GRCH 1462
            GHT +V+ P+ V      +  Q+SA   CH
Sbjct: 330  GHTCNVKCPSPVKGYWAAHSGQLSARAVCH 359



 Score =  160 bits (405), Expect = 5e-39
 Identities = 109/308 (35%), Positives = 161/308 (52%), Gaps = 5/308 (1%)
 Frame = +2

Query: 566  YGRLGQ-GNSDDLHVLTVISALQGFVVTQLV--TSCGSDGHSMALTESGEVFSWGDGDYG 736
            Y  LGQ G S +L  +     + GF+  + V   +CG D HS+ L E GEV++ G    G
Sbjct: 6    YWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGD-HSVFLLEDGEVYTCGLNTKG 64

Query: 737  KLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLGLGNTS 916
            +LGH       +P QI AL  E +V ++CG  HS  ++  G+LF++G G  G+LGL  T 
Sbjct: 65   QLGHEREGN--KPEQIGALADEHIVHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTE 122

Query: 917  NK-KLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNS-TAKSSP 1090
                +P  +  L    I QV+CG  H LA++ADG   + +G   +G+LGLG    +++SP
Sbjct: 123  ESVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQF-FTWGKNSHGQLGLGKEFPSQASP 181

Query: 1091 QKVDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGLPEGRARNHNRPQQIPVLAG 1270
            Q+V  L GI + +VA G   S AL+  G V+ +G +    L      +   P  + +L  
Sbjct: 182  QRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEEDRESPCHVKLLRA 241

Query: 1271 VVIEDVAVGAEHTLALASTGDVYAWGSNSEGQLGLGHTNHVREPTLVTVLQGKNVRQISA 1450
              +  ++ G EHT  L  +G V+ +G+ S GQLG    N    P  V  L G  V QI+ 
Sbjct: 242  QKVVYISCGEEHTAVLTKSGGVFTFGAGSCGQLGHDSMNDEVNPRRVLELMGSEVTQIAC 301

Query: 1451 GRCHSAAW 1474
            GR H+ A+
Sbjct: 302  GRQHTLAF 309



 Score =  136 bits (342), Expect = 9e-32
 Identities = 84/262 (32%), Positives = 128/262 (48%), Gaps = 5/262 (1%)
 Frame = +2

Query: 329  DEQIMSWATSRPEDWHLGGKCDVYLWGAGRHGQLA----EAGRNVMVXXXXXXXXXXXXV 496
            DE I+  A        L  +  ++ WGAG  GQL     E    V              V
Sbjct: 83   DEHIVHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTEESVAVPRLIQKLNQQTILQV 142

Query: 497  ICGQNCTFVIQANGTVLACGEGSYGRLGQGNSDDLHVLTV-ISALQGFVVTQLVTSCGSD 673
             CG      + A+G     G+ S+G+LG G           + +L+G  + Q+       
Sbjct: 143  SCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAG---G 199

Query: 674  GHSMALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTS 853
             HS AL+ SG VF WG  + G+LG  + + +  P  ++ L+ ++VV +SCG +H+AV+T 
Sbjct: 200  AHSFALSLSGAVFGWGMNNAGQLGLSDEEDRESPCHVKLLRAQKVVYISCGEEHTAVLTK 259

Query: 854  DGKLFTFGNGDYGRLGLGNTSNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAF 1033
             G +FTFG G  G+LG  + +++  P RV  L G ++ Q+ACG  HTLA      +++AF
Sbjct: 260  SGGVFTFGAGSCGQLGHDSMNDEVNPRRVLELMGSEVTQIACGRQHTLAFVPSSGLIYAF 319

Query: 1034 GDGDYGKLGLGNSTAKSSPQKV 1099
            G G  G+LG G++     P  V
Sbjct: 320  GCGARGQLGTGHTCNVKCPSPV 341



 Score =  123 bits (308), Expect = 8e-28
 Identities = 79/237 (33%), Positives = 125/237 (52%), Gaps = 2/237 (0%)
 Frame = +2

Query: 773  PRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLGLGNTSNKKLPERVTALE 952
            P+    +    V +++CG  HS  +  DG+++T G    G+LG     NK  PE++ AL 
Sbjct: 25   PQVCGFISDRSVKEVACGGDHSVFLLEDGEVYTCGLNTKGQLGHEREGNK--PEQIGALA 82

Query: 953  GYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNSTAKSS-PQKVDVLCGIGIKK 1129
               I  VACG +H+LA+S D   ++++G G  G+LGL  +    + P+ +  L    I +
Sbjct: 83   DEHIVHVACGESHSLALS-DRGQLFSWGAGSDGQLGLMTTEESVAVPRLIQKLNQQTILQ 141

Query: 1130 VACGTQFSVALTKDGHVYTFGQDRLIGLPEGRA-RNHNRPQQIPVLAGVVIEDVAVGAEH 1306
            V+CG    +AL  DG  +T+G++    L  G+   +   PQ++  L G+ +  VA G  H
Sbjct: 142  VSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAH 201

Query: 1307 TLALASTGDVYAWGSNSEGQLGLGHTNHVREPTLVTVLQGKNVRQISAGRCHSAAWT 1477
            + AL+ +G V+ WG N+ GQLGL        P  V +L+ + V  IS G  H+A  T
Sbjct: 202  SFALSLSGAVFGWGMNNAGQLGLSDEEDRESPCHVKLLRAQKVVYISCGEEHTAVLT 258


>ref|XP_003129374.2| PREDICTED: probable E3 ubiquitin-protein ligase HERC3-like [Sus
            scrofa].
          Length = 989

 Score =  165 bits (417), Expect = 2e-40
 Identities = 96/267 (35%), Positives = 154/267 (57%), Gaps = 3/267 (1%)
 Frame = +2

Query: 659  SCGSDGHSMALTESGEVFSWGDGDYGKLGHGNSDRQRR-PRQIEALQGEEVVQMSCGFKH 835
            +CG + HS+AL++ G++FSWG G  G+LG   ++     PR I+ L  + ++Q+SCG  H
Sbjct: 29   ACG-ESHSLALSDRGQLFSWGAGSDGQLGLMTTEESVAVPRLIQKLNQQTILQVSCGNWH 87

Query: 836  SAVVTSDGKLFTFGNGDYGRLGLGNT-SNKKLPERVTALEGYQIGQVACGLNHTLAVSAD 1012
               + +DG+ FT+G   +G+LGLG    ++  P+RV +LEG  + QVA G  H+ A+S  
Sbjct: 88   CLALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLS 147

Query: 1013 GSMVWAFGDGDYGKLGLGNSTAKSSPQKVDVLCGIGIKKVACGTQFSVALTKDGHVYTFG 1192
            G+ V+ +G  + G+LGL +   + SP  V +L    +  ++CG + +  LTK G V+TFG
Sbjct: 148  GA-VFGWGMNNAGQLGLSDEEDRESPCHVKLLRAQKVVYISCGEEHTAVLTKSGGVFTFG 206

Query: 1193 QDRLIGLPEGRARNHNRPQQIPVLAGVVIEDVAVGAEHTLALA-STGDVYAWGSNSEGQL 1369
                  L      +   P+++  L G  +  +A G +HTLA   S+G +YA+G  + GQL
Sbjct: 207  AGSCGQLGHDSMNDEVNPRRVLELMGSEVTQIACGRQHTLAFVPSSGLIYAFGCGARGQL 266

Query: 1370 GLGHTNHVREPTLVTVLQGKNVRQISA 1450
            G GHT +V+ P+ V      +  Q+SA
Sbjct: 267  GTGHTCNVKCPSPVKGYWAAHSGQLSA 293



 Score =  136 bits (342), Expect = 9e-32
 Identities = 84/262 (32%), Positives = 128/262 (48%), Gaps = 5/262 (1%)
 Frame = +2

Query: 329  DEQIMSWATSRPEDWHLGGKCDVYLWGAGRHGQLA----EAGRNVMVXXXXXXXXXXXXV 496
            DE I+  A        L  +  ++ WGAG  GQL     E    V              V
Sbjct: 22   DEHIVHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTEESVAVPRLIQKLNQQTILQV 81

Query: 497  ICGQNCTFVIQANGTVLACGEGSYGRLGQGNSDDLHVLTV-ISALQGFVVTQLVTSCGSD 673
             CG      + A+G     G+ S+G+LG G           + +L+G  + Q+       
Sbjct: 82   SCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAG---G 138

Query: 674  GHSMALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTS 853
             HS AL+ SG VF WG  + G+LG  + + +  P  ++ L+ ++VV +SCG +H+AV+T 
Sbjct: 139  AHSFALSLSGAVFGWGMNNAGQLGLSDEEDRESPCHVKLLRAQKVVYISCGEEHTAVLTK 198

Query: 854  DGKLFTFGNGDYGRLGLGNTSNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAF 1033
             G +FTFG G  G+LG  + +++  P RV  L G ++ Q+ACG  HTLA      +++AF
Sbjct: 199  SGGVFTFGAGSCGQLGHDSMNDEVNPRRVLELMGSEVTQIACGRQHTLAFVPSSGLIYAF 258

Query: 1034 GDGDYGKLGLGNSTAKSSPQKV 1099
            G G  G+LG G++     P  V
Sbjct: 259  GCGARGQLGTGHTCNVKCPSPV 280



 Score =  131 bits (330), Expect = 2e-30
 Identities = 83/234 (35%), Positives = 124/234 (52%), Gaps = 2/234 (0%)
 Frame = +2

Query: 779  QIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLGLGNTSNK-KLPERVTALEG 955
            QI AL  E +V ++CG  HS  ++  G+LF++G G  G+LGL  T     +P  +  L  
Sbjct: 16   QIGALADEHIVHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTEESVAVPRLIQKLNQ 75

Query: 956  YQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNS-TAKSSPQKVDVLCGIGIKKV 1132
              I QV+CG  H LA++ADG   + +G   +G+LGLG    +++SPQ+V  L GI + +V
Sbjct: 76   QTILQVSCGNWHCLALAADGQF-FTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQV 134

Query: 1133 ACGTQFSVALTKDGHVYTFGQDRLIGLPEGRARNHNRPQQIPVLAGVVIEDVAVGAEHTL 1312
            A G   S AL+  G V+ +G +    L      +   P  + +L    +  ++ G EHT 
Sbjct: 135  AAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEEDRESPCHVKLLRAQKVVYISCGEEHTA 194

Query: 1313 ALASTGDVYAWGSNSEGQLGLGHTNHVREPTLVTVLQGKNVRQISAGRCHSAAW 1474
             L  +G V+ +G+ S GQLG    N    P  V  L G  V QI+ GR H+ A+
Sbjct: 195  VLTKSGGVFTFGAGSCGQLGHDSMNDEVNPRRVLELMGSEVTQIACGRQHTLAF 248



 Score = 97.8 bits (242), Expect = 4e-20
 Identities = 63/184 (34%), Positives = 99/184 (53%), Gaps = 2/184 (1%)
 Frame = +2

Query: 932  ERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNSTAKSS-PQKVDVL 1108
            E++ AL    I  VACG +H+LA+S D   ++++G G  G+LGL  +    + P+ +  L
Sbjct: 15   EQIGALADEHIVHVACGESHSLALS-DRGQLFSWGAGSDGQLGLMTTEESVAVPRLIQKL 73

Query: 1109 CGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGLPEGRA-RNHNRPQQIPVLAGVVIED 1285
                I +V+CG    +AL  DG  +T+G++    L  G+   +   PQ++  L G+ +  
Sbjct: 74   NQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQ 133

Query: 1286 VAVGAEHTLALASTGDVYAWGSNSEGQLGLGHTNHVREPTLVTVLQGKNVRQISAGRCHS 1465
            VA G  H+ AL+ +G V+ WG N+ GQLGL        P  V +L+ + V  IS G  H+
Sbjct: 134  VAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEEDRESPCHVKLLRAQKVVYISCGEEHT 193

Query: 1466 AAWT 1477
            A  T
Sbjct: 194  AVLT 197



 Score = 97.1 bits (240), Expect = 6e-20
 Identities = 91/337 (27%), Positives = 144/337 (42%), Gaps = 4/337 (1%)
 Frame = +2

Query: 1910 DLRLPSRAWKVKLVGEGADDAGGVFDDTITEMCQELETGIVDLLIPSPNATAEVGYNRDR 2089
            DL+ P    KV   GE A DAGGV  +    + +EL   I  +            Y    
Sbjct: 665  DLKKPL---KVIFDGEEAVDAGGVTKEFFLLLLKELLNPIYGMF---------TYYQDSN 712

Query: 2090 FLFNPSACLDEHLMQFKFLGILMGVAIRTKKPLDLHLAPLVWKQLCCVPXXXXXXXXXXX 2269
             L+    C  EH   F  +GI  G+AI     +DLH    ++K+L  V            
Sbjct: 713  LLWFSDTCFVEHNW-FHLIGITCGLAIYNSTVVDLHFPLALYKKLLNVQPGLEDLKELSP 771

Query: 2270 XYVQTLNSILHIEDSGITEESFHEMIPLDSFVGQSADG--KMVPIIPGGNSIPLTFSNRK 2443
               ++L  +L      I EE+F     L+  + + + G  +   +IPGG+ + +   NR+
Sbjct: 772  AEGRSLQELLDYPGEDI-EETFC----LNFTICRESYGVVEQKKLIPGGDRVTVCKENRQ 826

Query: 2444 EYVERAIEYRLH-EMDRQVAAVREGMSWIVPVPLLSLLTAKQLEQMVCGMPEISVEVLKK 2620
            E+V+  + Y     +     A   G   +    +L L    +L  M+ G    + E L++
Sbjct: 827  EFVDAYVNYVFQISVGEWYTAFSSGFLKVCGGKVLELFQPSELRAMMVGNSNYNWEELEE 886

Query: 2621 VVRYR-EVDEQHQLVQWFWHTLEEFSNEERVLFMRFVSGRSRLPANTADISQRFQIMKVD 2797
               Y+ +    H  V+ FW T  EF  E++  F+ F++G  R+P      S +  I    
Sbjct: 887  TAVYKGDYSAAHPTVKLFWETFHEFPLEKKKKFLLFLTGSDRIPIYGM-ASLQIVIQSTA 945

Query: 2798 RPYDSLPTSQTCFFQLRLPPYSSQLVMAERLRYAINN 2908
               D LP + TC+  L LP YSS+ V+  RL  A++N
Sbjct: 946  SGEDYLPVAHTCYNLLDLPKYSSKEVLRARLTQALDN 982


>ref|XP_001928937.1| PREDICTED: RCC1 and BTB domain-containing protein 2 isoform 1 [Sus
            scrofa].
          Length = 568

 Score =  151 bits (382), Expect = 2e-36
 Identities = 95/289 (32%), Positives = 150/289 (51%), Gaps = 3/289 (1%)
 Frame = +2

Query: 533  NGTVLACGEGSYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSDGHSMALTESGEVF 712
            N  +   G    G LG G+         + +L G  +  L  S GS  H +  T  GEVF
Sbjct: 81   NDEIFVLGTNCCGCLGLGDVQSTIEPRRLDSLSGKKIACL--SYGSGPHVVLATTEGEVF 138

Query: 713  SWGDGDYGKLGHGNSDRQRRPRQIEA-LQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDY 889
            +WG   Y +LG+G ++    P  I   L  ++V++++CG  HS V+TSDG++F +G  + 
Sbjct: 139  TWGHNAYSQLGNGTTNHGLVPCHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWGYNNS 198

Query: 890  GRLGLGNTSNKKLPERVTA-LEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLG 1066
            G++G G+T+N+ +P RVT  L+   +  +ACG   ++AV  D   V+ +G    G+LGLG
Sbjct: 199  GQVGSGSTANQPIPRRVTGCLQNKTVVNIACGQMCSMAV-VDTGEVYVWGYNGNGQLGLG 257

Query: 1067 NSTAKSSPQKVDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGLPEGRARNHNRP 1246
            +   + +P ++  L GI +++VACG   ++ LT +G VY +G +    L  G   N + P
Sbjct: 258  SGGNQPTPCRIAALQGIRVQRVACGYAHTLVLTDEGQVYAWGANSYGQLGTGNKSNQSYP 317

Query: 1247 QQIPVLAGVVIEDVAVGAEHTLALAST-GDVYAWGSNSEGQLGLGHTNH 1390
              + V    +IE  A  + HT A  +  G VY WG      + L H  H
Sbjct: 318  TPVIVEKDRIIEIAACHSAHTSAAKTQGGHVYMWGQCRGQSVTLPHLTH 366



 Score =  149 bits (376), Expect = 1e-35
 Identities = 96/276 (34%), Positives = 153/276 (55%), Gaps = 4/276 (1%)
 Frame = +2

Query: 665  GSDGHSMALTE-SGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGF-KHS 838
            GS G+ +  T  + E+F  G    G LG G+      PR++++L G+++  +S G   H 
Sbjct: 69   GSAGNEVLYTTVNDEIFVLGTNCCGCLGLGDVQSTIEPRRLDSLSGKKIACLSYGSGPHV 128

Query: 839  AVVTSDGKLFTFGNGDYGRLGLGNTSNKKLPERV-TALEGYQIGQVACGLNHTLAVSADG 1015
             + T++G++FT+G+  Y +LG G T++  +P  + T L   Q+ +VACG  H+L +++DG
Sbjct: 129  VLATTEGEVFTWGHNAYSQLGNGTTNHGLVPCHISTNLSNKQVIEVACGSYHSLVLTSDG 188

Query: 1016 SMVWAFGDGDYGKLGLGNSTAKSSPQKVD-VLCGIGIKKVACGTQFSVALTKDGHVYTFG 1192
              V+A+G  + G++G G++  +  P++V   L    +  +ACG   S+A+   G VY +G
Sbjct: 189  E-VFAWGYNNSGQVGSGSTANQPIPRRVTGCLQNKTVVNIACGQMCSMAVVDTGEVYVWG 247

Query: 1193 QDRLIGLPEGRARNHNRPQQIPVLAGVVIEDVAVGAEHTLALASTGDVYAWGSNSEGQLG 1372
             +    L  G   N   P +I  L G+ ++ VA G  HTL L   G VYAWG+NS GQLG
Sbjct: 248  YNGNGQLGLGSGGNQPTPCRIAALQGIRVQRVACGYAHTLVLTDEGQVYAWGANSYGQLG 307

Query: 1373 LGHTNHVREPTLVTVLQGKNVRQISAGRCHSAAWTA 1480
             G+ ++   PT V V   +  R I    CHSA  +A
Sbjct: 308  TGNKSNQSYPTPVIV---EKDRIIEIAACHSAHTSA 340



 Score =  110 bits (274), Expect = 7e-24
 Identities = 71/220 (32%), Positives = 111/220 (50%), Gaps = 5/220 (2%)
 Frame = +2

Query: 392  DVYLWGAGRHGQLAEAGRNV-MVXXXXXXXXXXXXVI---CGQNCTFVIQANGTVLACGE 559
            +V+ WG   + QL     N  +V            VI   CG   + V+ ++G V A G 
Sbjct: 136  EVFTWGHNAYSQLGNGTTNHGLVPCHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWGY 195

Query: 560  GSYGRLGQGNSDDLHV-LTVISALQGFVVTQLVTSCGSDGHSMALTESGEVFSWGDGDYG 736
             + G++G G++ +  +   V   LQ   V  +  +CG    SMA+ ++GEV+ WG    G
Sbjct: 196  NNSGQVGSGSTANQPIPRRVTGCLQNKTVVNI--ACGQMC-SMAVVDTGEVYVWGYNGNG 252

Query: 737  KLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLGLGNTS 916
            +LG G+   Q  P +I ALQG  V +++CG+ H+ V+T +G+++ +G   YG+LG GN S
Sbjct: 253  QLGLGSGGNQPTPCRIAALQGIRVQRVACGYAHTLVLTDEGQVYAWGANSYGQLGTGNKS 312

Query: 917  NKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFG 1036
            N+  P  V   +   I   AC   HT A    G  V+ +G
Sbjct: 313  NQSYPTPVIVEKDRIIEIAACHSAHTSAAKTQGGHVYMWG 352


>ref|XP_003135065.2| PREDICTED: hypothetical protein LOC100511730 [Sus scrofa].
          Length = 1224

 Score =  144 bits (362), Expect = 4e-34
 Identities = 91/277 (32%), Positives = 150/277 (54%), Gaps = 4/277 (1%)
 Frame = +2

Query: 659  SCGSDGHSMALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHS 838
            SCG D H+  +T + ++F +G  ++G+LG G+     +P  ++AL+ E+V   +CG  H+
Sbjct: 41   SCG-DEHTAIITGNNKLFMFGSNNWGQLGLGSKSTVDKPTCVKALKPEKVKFAACGRNHT 99

Query: 839  AVVTSDGKLFTFGNGDYGRLGLGNTSNKKLPERVTALEG-YQIGQVACGLNHTLAVSADG 1015
             + T  GK++  G  + G+LGLG+T  +     +      ++I Q++ G N + A++ DG
Sbjct: 100  LISTEGGKVYAAGGNNEGQLGLGDTEERNTFHVINFFTSQHKIKQLSAGSNTSAALTEDG 159

Query: 1016 SMVWAFGDGDYGKLGLGNSTAKSSPQKVDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQ 1195
             + + +GD   G++GL N T+   P +V +  G  I  ++CG   S  +T +G +YTFG+
Sbjct: 160  EL-FMWGDNSEGQIGLQNMTSICVPHQVTI--GKPISWISCGYYHSAFVTTEGELYTFGE 216

Query: 1196 DRL--IGLPEGRARNHNRPQQIPVLAGVVIEDVAVGAEHTLALASTGDVYAWGSNSEGQL 1369
                 +GLP     NH  PQ +P +   VI+ VA G  HT+AL     VY +G    GQL
Sbjct: 217  PECGKLGLPRKLLVNHRVPQLVPGIPEKVIQ-VACGGGHTVALTENA-VYVFGLGQFGQL 274

Query: 1370 GLG-HTNHVREPTLVTVLQGKNVRQISAGRCHSAAWT 1477
            GLG       EP ++  ++ + +  IS G  H+A  T
Sbjct: 275  GLGTFIFETSEPKVIDNIKDQKISYISCGENHTALIT 311



 Score =  135 bits (341), Expect = 1e-31
 Identities = 102/336 (30%), Positives = 168/336 (50%), Gaps = 8/336 (2%)
 Frame = +2

Query: 500  CGQNCTFVIQANGTVLACGEGSYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSDGH 679
            CG   T +I  N  +   G  ++G+LG G+   +   T + AL+   V     +CG + H
Sbjct: 42   CGDEHTAIITGNNKLFMFGSNNWGQLGLGSKSTVDKPTCVKALKPEKVK--FAACGRN-H 98

Query: 680  SMALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGE-EVVQMSCGFKHSAVVTSD 856
            ++  TE G+V++ G  + G+LG G+++ +     I     + ++ Q+S G   SA +T D
Sbjct: 99   TLISTEGGKVYAAGGNNEGQLGLGDTEERNTFHVINFFTSQHKIKQLSAGSNTSAALTED 158

Query: 857  GKLFTFGNGDYGRLGLGNTSNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFG 1036
            G+LF +G+   G++GL N ++  +P +VT   G  I  ++CG  H+  V+ +G + + FG
Sbjct: 159  GELFMWGDNSEGQIGLQNMTSICVPHQVTI--GKPISWISCGYYHSAFVTTEGEL-YTFG 215

Query: 1037 DGDYGKLGLGNSTAKSS--PQKVDVLCGIGIK--KVACGTQFSVALTKDGHVYTFGQDRL 1204
            + + GKLGL      +   PQ V    GI  K  +VACG   +VALT++  VY FG  + 
Sbjct: 216  EPECGKLGLPRKLLVNHRVPQLVP---GIPEKVIQVACGGGHTVALTENA-VYVFGLGQF 271

Query: 1205 IGLPEGR-ARNHNRPQQIPVLAGVVIEDVAVGAEHTLALASTGDVYAWGSNSEGQLGLGH 1381
              L  G      + P+ I  +    I  ++ G  HT  +   G +Y +G    G+LGLG 
Sbjct: 272  GQLGLGTFIFETSEPKVIDNIKDQKISYISCGENHTALITDLGLMYTFGDGRHGKLGLGL 331

Query: 1382 TNHVRE--PTLVTVLQGKNVRQISAGRCHSAAWTAP 1483
             N   +  PTL +      V+ ++ G CH   +  P
Sbjct: 332  ENFTNQFIPTLCSNFLRFIVQLVACGGCHMLVFATP 367



 Score = 82.8 bits (203), Expect = 1e-15
 Identities = 57/206 (27%), Positives = 105/206 (50%), Gaps = 4/206 (1%)
 Frame = +2

Query: 392 DVYLWGAGRHGQLA-EAGRNVMVXXXXXXXXXXXXVICGQNCTFVIQANGTVLACGEGSY 568
           ++++WG    GQ+  +   ++ V            + CG   +  +   G +   GE   
Sbjct: 160 ELFMWGDNSEGQIGLQNMTSICVPHQVTIGKPISWISCGYYHSAFVTTEGELYTFGEPEC 219

Query: 569 GRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSDGHSMALTESGEVFSWGDGDYGKLGH 748
           G+LG      ++   V   + G     +  +CG  GH++ALTE+  V+ +G G +G+LG 
Sbjct: 220 GKLGLPRKLLVNH-RVPQLVPGIPEKVIQVACGG-GHTVALTENA-VYVFGLGQFGQLGL 276

Query: 749 GNSDRQR-RPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLGLG--NTSN 919
           G    +   P+ I+ ++ +++  +SCG  H+A++T  G ++TFG+G +G+LGLG  N +N
Sbjct: 277 GTFIFETSEPKVIDNIKDQKISYISCGENHTALITDLGLMYTFGDGRHGKLGLGLENFTN 336

Query: 920 KKLPERVTALEGYQIGQVACGLNHTL 997
           + +P   +    + +  VACG  H L
Sbjct: 337 QFIPTLCSNFLRFIVQLVACGGCHML 362


>ref|XP_003357882.1| PREDICTED: RCC1 and BTB domain-containing protein 1 [Sus scrofa].
          Length = 531

 Score =  143 bits (361), Expect = 6e-34
 Identities = 91/274 (33%), Positives = 152/274 (55%), Gaps = 3/274 (1%)
 Frame = +2

Query: 668  SDGHSMALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGF-KHSAV 844
            S   ++ +T++ EVF +G      LG G++     P+++EAL G+++  +S G   H  +
Sbjct: 30   SANEALYVTDNDEVFVFGLNYSNCLGTGDNQSTLVPKKLEALCGKKIKSLSYGSGPHVLL 89

Query: 845  VTSDGKLFTFGNGDYGRLGLGNTSNKKLPERV-TALEGYQIGQVACGLNHTLAVSADGSM 1021
             T DG ++ +G+  Y +LG G T+    P +V T L   Q+ +VACG +H++A++ADG  
Sbjct: 90   STEDGVVYAWGHNGYSQLGNGTTNQGIAPIQVCTNLLIKQVVEVACGSHHSMALAADGE- 148

Query: 1022 VWAFGDGDYGKLGLGNSTAKSSPQKVDVLCGIG-IKKVACGTQFSVALTKDGHVYTFGQD 1198
            V+A+G  + G++G G++  + +P+KV     I  +  +ACG   S+A+  +G VY +G +
Sbjct: 149  VFAWGYNNCGQVGSGSTANQPTPRKVTNCLHIKRVVSIACGQTSSMAVLDNGEVYGWGYN 208

Query: 1199 RLIGLPEGRARNHNRPQQIPVLAGVVIEDVAVGAEHTLALASTGDVYAWGSNSEGQLGLG 1378
                L  G   N   P ++  L  V +  +  G  HTLAL   G +YAWG+N+ GQLG G
Sbjct: 209  GNGQLGLGNNGNQLTPVRVAALHSVCVNQIVCGYAHTLALTDEGLLYAWGANTYGQLGTG 268

Query: 1379 HTNHVREPTLVTVLQGKNVRQISAGRCHSAAWTA 1480
            + N++  P  + V   +  R +    CHSA  +A
Sbjct: 269  NKNNLLSPAHIMV---EKERVVEIAACHSAHTSA 299



 Score =  140 bits (353), Expect = 5e-33
 Identities = 93/297 (31%), Positives = 151/297 (50%), Gaps = 3/297 (1%)
 Frame = +2

Query: 509  NCTFVIQANGTVLACGEGSYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSDGHSMA 688
            N    +  N  V   G      LG G++    V   + AL G  +  L  S GS  H + 
Sbjct: 32   NEALYVTDNDEVFVFGLNYSNCLGTGDNQSTLVPKKLEALCGKKIKSL--SYGSGPHVLL 89

Query: 689  LTESGEVFSWGDGDYGKLGHGNSDRQRRPRQI-EALQGEEVVQMSCGFKHSAVVTSDGKL 865
             TE G V++WG   Y +LG+G +++   P Q+   L  ++VV+++CG  HS  + +DG++
Sbjct: 90   STEDGVVYAWGHNGYSQLGNGTTNQGIAPIQVCTNLLIKQVVEVACGSHHSMALAADGEV 149

Query: 866  FTFGNGDYGRLGLGNTSNKKLPERVT-ALEGYQIGQVACGLNHTLAVSADGSMVWAFGDG 1042
            F +G  + G++G G+T+N+  P +VT  L   ++  +ACG   ++AV  +G  V+ +G  
Sbjct: 150  FAWGYNNCGQVGSGSTANQPTPRKVTNCLHIKRVVSIACGQTSSMAVLDNGE-VYGWGYN 208

Query: 1043 DYGKLGLGNSTAKSSPQKVDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGLPEG 1222
              G+LGLGN+  + +P +V  L  + + ++ CG   ++ALT +G +Y +G +    L  G
Sbjct: 209  GNGQLGLGNNGNQLTPVRVAALHSVCVNQIVCGYAHTLALTDEGLLYAWGANTYGQLGTG 268

Query: 1223 RARNHNRPQQIPVLAGVVIEDVAVGAEHTLALAST-GDVYAWGSNSEGQLGLGHTNH 1390
               N   P  I V    V+E  A  + HT A  +  G VY WG      + L H  H
Sbjct: 269  NKNNLLSPAHIMVEKERVVEIAACHSAHTSAAKTQGGHVYMWGQCRGQSVTLPHLTH 325



 Score =  102 bits (254), Expect = 1e-21
 Identities = 66/228 (28%), Positives = 103/228 (45%), Gaps = 14/228 (6%)
 Frame = +2

Query: 395  VYLWGAGRHGQLAEAGRNVMVXXXXXXXXXXXX----VICGQNCTFVIQANGTVLACGEG 562
            VY WG   + QL     N  +                V CG + +  + A+G V A G  
Sbjct: 96   VYAWGHNGYSQLGNGTTNQGIAPIQVCTNLLIKQVVEVACGSHHSMALAADGEVFAWGYN 155

Query: 563  SYGRLGQGNSDD----------LHVLTVISALQGFVVTQLVTSCGSDGHSMALTESGEVF 712
            + G++G G++ +          LH+  V+S            +CG    SMA+ ++GEV+
Sbjct: 156  NCGQVGSGSTANQPTPRKVTNCLHIKRVVSI-----------ACGQTS-SMAVLDNGEVY 203

Query: 713  SWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYG 892
             WG    G+LG GN+  Q  P ++ AL    V Q+ CG+ H+  +T +G L+ +G   YG
Sbjct: 204  GWGYNGNGQLGLGNNGNQLTPVRVAALHSVCVNQIVCGYAHTLALTDEGLLYAWGANTYG 263

Query: 893  RLGLGNTSNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFG 1036
            +LG GN +N   P  +   +   +   AC   HT A    G  V+ +G
Sbjct: 264  QLGTGNKNNLLSPAHIMVEKERVVEIAACHSAHTSAAKTQGGHVYMWG 311


>ref|XP_001924648.3| PREDICTED: probable E3 ubiquitin-protein ligase C12orf51-like [Sus
            scrofa].
          Length = 4246

 Score =  142 bits (358), Expect = 1e-33
 Identities = 133/502 (26%), Positives = 221/502 (44%), Gaps = 46/502 (9%)
 Frame = +2

Query: 1538 DAVPPQYGALREVSIHTARARLRLLYHFSDLMYSSWRLLNLSPNNQNSTSHYNAGTWGIV 1717
            DA  P+   L  + I + R R  LL   +  + + +    L       T  Y      ++
Sbjct: 3746 DAADPRVACLLNMPIESLRLRFALLQSLNTTLETFF----LPLVELRQTPMYTHSIAALL 3801

Query: 1718 QGQLRPLLAPRVYTLPMVRSIGKTMVQGKNYG-PQITVKRISTRGRKCKP----IFVQIA 1882
            Q + + L+        M R +  T+ +  ++  P+IT+  +   G + +      F Q A
Sbjct: 3802 Q-EAKGLIFYDTKVTVMNRVLNATVQRTADHAAPEITLDPLEIVGGEIRASENSYFCQAA 3860

Query: 1883 RQVVKLNASDLRL-------PSRAWKVKLVGEGADDAGGVFDDTITEMCQELETGIVDLL 2041
            RQ+  + +S L +       P+ A+ ++  GE      G F   + ++C+EL++  + LL
Sbjct: 3861 RQLASVPSSQLCVKLASGGDPTYAFNIRFTGEEVHGTSGSFRHFLWQVCKELQSSSLSLL 3920

Query: 2042 IPSPNATAEVGYNRDRFLFNPSACLDEHLMQFKFLGILMGVAIRTKKPLDLHLAPLVWKQ 2221
            +  P++   V  N+ +++  PS           FLG L+G+AIR   PL L L P  WK 
Sbjct: 3921 LLCPSSA--VNKNKGKYILTPSPITYGEEQLLHFLGQLLGIAIRADVPLPLDLLPSFWKT 3978

Query: 2222 LCCVPXXXXXXXXXXXX----YVQTLNSIL-HIEDSGITEESFHEMIPLDS--------- 2359
            L   P                YV+   SI   IE   +  E   + +  +S         
Sbjct: 3979 LVGEPLDPDQDLQEADILTYNYVKKFESINDEIELEALCAEIASQHLATESPDGPNKPCC 4038

Query: 2360 -FVGQSADGKMVPIIPGGNSIPLTFSNRKEYVERAIEYRLHEMDRQ--VAAVREGMSWIV 2530
             F   +  G+ V +   G  IP+ + N+  Y       RL E+     V AVR G+  I+
Sbjct: 4039 RFTYLTMTGEEVELCSRGRHIPVAWENKDIYAATIRSLRLRELQNVECVTAVRAGLGSII 4098

Query: 2531 PVPLLSLLTAKQLEQMVCGMPEISVEVLKKVVRYR-EVDEQHQLVQWFWHTLEEFSNEER 2707
            P+ LL+ L+  ++E   CG+P I++E LK    Y+  + E  Q +++FW  LE F+ EE 
Sbjct: 4099 PLQLLTTLSPLEMELRTCGLPYINLEFLKAHTMYQVGLMETDQHIEFFWGALEMFAQEEL 4158

Query: 2708 VLFMRFVSGRSRLP---------ANTADISQRFQIMKVDRPYDSL--PTS-----QTCFF 2839
              F++F   + R+P          +TA +      MK+  P  +   P S     +TC F
Sbjct: 4159 CKFIKFACNQERIPFTCPCKDGGPDTAHVPP--YPMKIAPPDGTAGSPDSRYIRVETCMF 4216

Query: 2840 QLRLPPYSSQLVMAERLRYAIN 2905
             ++LP YSS  +M E+LR AI+
Sbjct: 4217 MIKLPQYSSLEIMLEKLRCAIH 4238


  Database: RefSeq49_SP.fasta
    Posted date:  Oct 17, 2011  1:42 PM
  Number of letters in database: 11,343,932
  Number of sequences in database:  24,897
  
Lambda     K      H
   0.318    0.134    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 24897
Number of Hits to DB: 87,588,253
Number of extensions: 2461966
Number of successful extensions: 8348
Number of sequences better than 1.0e-05: 43
Number of HSP's gapped: 7838
Number of HSP's successfully gapped: 111
Length of query: 1168
Length of database: 11,343,932
Length adjustment: 110
Effective length of query: 1058
Effective length of database: 8,605,262
Effective search space: 9104367196
Effective search space used: 9104367196
Neighboring words threshold: 12
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 35 (18.1 bits)

BLASTN 2.2.24 [Aug-08-2010]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= 20110601C-003115
         (3506 letters)

Database: Sscrofa_10.2.fasta 
           4582 sequences; 2,808,509,378 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

Sscrofa_Chr01                                                         739   0.0  
gb|GL894430.2| Sus scrofa unplaced genomic scaffold ChrUScaf2314      589   e-165

>Sscrofa_Chr01 
||          Length = 315321322

 Score =  739 bits (373), Expect = 0.0
 Identities = 373/373 (100%)
 Strand = Plus / Plus

                                                                             
Query: 2800      gccttatgacagtctgcctacctcacagacctgcttcttccagctgaggctgccccctta 2859
                 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 119559877 gccttatgacagtctgcctacctcacagacctgcttcttccagctgaggctgccccctta 119559936

                                                                             
Query: 2860      ttctagccagctggtcatggccgagcgcctgcgctatgccatcaacaactgccgctccat 2919
                 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 119559937 ttctagccagctggtcatggccgagcgcctgcgctatgccatcaacaactgccgctccat 119559996

                                                                             
Query: 2920      tgacatggacaactacatgctctcccgaaacgtggacaacgccgagggctccgacactga 2979
                 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 119559997 tgacatggacaactacatgctctcccgaaacgtggacaacgccgagggctccgacactga 119560056

                                                                             
Query: 2980      ctactgaccgccaagggtgccgtcacccctctttcttgtcagtaatgctcacttccagtt 3039
                 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 119560057 ctactgaccgccaagggtgccgtcacccctctttcttgtcagtaatgctcacttccagtt 119560116

                                                                             
Query: 3040      taatgttgatatacttttatggtaactatatagatgttttaggaacataaaccaacatta 3099
                 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 119560117 taatgttgatatacttttatggtaactatatagatgttttaggaacataaaccaacatta 119560176

                                                                             
Query: 3100      taaacagtggccacacttagttactctgaatgtaacaaagaaattagatgtttttatttt 3159
                 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 119560177 taaacagtggccacacttagttactctgaatgtaacaaagaaattagatgtttttatttt 119560236

                              
Query: 3160      tctgtgattgtac 3172
                 |||||||||||||
Sbjct: 119560237 tctgtgattgtac 119560249



 Score =  605 bits (305), Expect = e-170
 Identities = 308/309 (99%)
 Strand = Plus / Plus

                                                                             
Query: 2492      caggtggctgcagtccgagaagggatgtcctggatcgtccctgtgccgctgctgtccctc 2551
                 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 119556784 caggtggctgcagtccgagaagggatgtcctggatcgtccctgtgccgctgctgtccctc 119556843

                                                                             
Query: 2552      ctcactgcaaagcagctggagcagatggtgtgcgggatgcctgagatctccgtagaagtc 2611
                 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 119556844 ctcactgcaaagcagctggagcagatggtgtgcgggatgcctgagatctccgtagaagtc 119556903

                                                                             
Query: 2612      ttaaagaaagtggtgcggtaccgggaggtggacgagcagcatcagctggtacagtggttc 2671
                 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 119556904 ttaaagaaagtggtgcggtaccgggaggtggacgagcagcatcagctggtacagtggttc 119556963

                                                                             
Query: 2672      tggcacacactggaggagttctccaatgaggagcgcgtgctcttcatgaggtttgtgtct 2731
                 ||||||||||||||||||||||||||||||||||| ||||||||||||||||||||||||
Sbjct: 119556964 tggcacacactggaggagttctccaatgaggagcgtgtgctcttcatgaggtttgtgtct 119557023

                                                                             
Query: 2732      ggaagatctcgactcccagccaacactgctgacatttctcagagatttcagatcatgaag 2791
                 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 119557024 ggaagatctcgactcccagccaacactgctgacatttctcagagatttcagatcatgaag 119557083

                          
Query: 2792      gttgatagg 2800
                 |||||||||
Sbjct: 119557084 gttgatagg 119557092



 Score =  589 bits (297), Expect = e-165
 Identities = 297/297 (100%)
 Strand = Plus / Plus

                                                                             
Query: 6         agcctcatgtggtttgtggtgaccagcttgttcatagcccctatatgcaatgtctggctt 65
                 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 119536534 agcctcatgtggtttgtggtgaccagcttgttcatagcccctatatgcaatgtctggctt 119536593

                                                                             
Query: 66        cccttgctgtgggacttcatctggatcagctgctgtgtaaccctccagtgccaccacacc 125
                 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 119536594 cccttgctgtgggacttcatctggatcagctgctgtgtaaccctccagtgccaccacacc 119536653

                                                                             
Query: 126       accagaactgccttcctgaccctgcatcctggaatccaaatgagtgggcctggttagaat 185
                 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 119536654 accagaactgccttcctgaccctgcatcctggaatccaaatgagtgggcctggttagaat 119536713

                                                                             
Query: 186       gtttctcaaccaccataaaagccgctgaagccctgaccaatggagcacagtttccagaat 245
                 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 119536714 gtttctcaaccaccataaaagccgctgaagccctgaccaatggagcacagtttccagaat 119536773

                                                                          
Query: 246       cttttagtgttcccgatctagagcctgttccagaggatgaacttgtattcctaatgg 302
                 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 119536774 cttttagtgttcccgatctagagcctgttccagaggatgaacttgtattcctaatgg 119536830



 Score =  507 bits (256), Expect = e-140
 Identities = 256/256 (100%)
 Strand = Plus / Plus

                                                                             
Query: 2086      caggttcctttttaacccttctgcctgcctcgatgaacacttaatgcagtttaaattctt 2145
                 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 119553468 caggttcctttttaacccttctgcctgcctcgatgaacacttaatgcagtttaaattctt 119553527

                                                                             
Query: 2146      gggaattttaatgggggttgccattcgtacaaagaagcctctggacctccacttggcccc 2205
                 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 119553528 gggaattttaatgggggttgccattcgtacaaagaagcctctggacctccacttggcccc 119553587

                                                                             
Query: 2206      tctggtatggaagcagctgtgctgcgtcccactcaccctggaagacctggaggaggtgga 2265
                 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 119553588 tctggtatggaagcagctgtgctgcgtcccactcaccctggaagacctggaggaggtgga 119553647

                                                                             
Query: 2266      tctgctctatgtgcagactctcaacagcattcttcacattgaagacagtgggattactga 2325
                 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 119553648 tctgctctatgtgcagactctcaacagcattcttcacattgaagacagtgggattactga 119553707

                                 
Query: 2326      ggagagtttccatgag 2341
                 ||||||||||||||||
Sbjct: 119553708 ggagagtttccatgag 119553723



 Score =  365 bits (184), Expect = 1e-97
 Identities = 184/184 (100%)
 Strand = Plus / Plus

                                                                             
Query: 631       aggctttgtggtgacccagctggtgacttcctgtggttctgatgggcactccatggccct 690
                 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 119540439 aggctttgtggtgacccagctggtgacttcctgtggttctgatgggcactccatggccct 119540498

                                                                             
Query: 691       gactgaaagtggtgaggtctttagctggggagatggtgattatggcaaactcggccatgg 750
                 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 119540499 gactgaaagtggtgaggtctttagctggggagatggtgattatggcaaactcggccatgg 119540558

                                                                             
Query: 751       gaacagcgacaggcagcggcggcccaggcaaatcgaggccttacaaggagaagaagtggt 810
                 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 119540559 gaacagcgacaggcagcggcggcccaggcaaatcgaggccttacaaggagaagaagtggt 119540618

                     
Query: 811       gcag 814
                 ||||
Sbjct: 119540619 gcag 119540622



 Score =  343 bits (173), Expect = 4e-91
 Identities = 173/173 (100%)
 Strand = Plus / Plus

                                                                             
Query: 1673      cagaatagtacatctcattataatgctggaacatggggcattgtgcagggacagcttcgg 1732
                 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 119550885 cagaatagtacatctcattataatgctggaacatggggcattgtgcagggacagcttcgg 119550944

                                                                             
Query: 1733      cctttgttagccccaagagtctacaccctcccaatggtgcgctctataggaaaaaccatg 1792
                 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 119550945 cctttgttagccccaagagtctacaccctcccaatggtgcgctctataggaaaaaccatg 119551004

                                                                      
Query: 1793      gttcaaggcaaaaactatggacctcaaattactgtaaagaggatatcaaccag 1845
                 |||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 119551005 gttcaaggcaaaaactatggacctcaaattactgtaaagaggatatcaaccag 119551057



 Score =  341 bits (172), Expect = 2e-90
 Identities = 172/172 (100%)
 Strand = Plus / Plus

                                                                             
Query: 1195      agatcgcttgataggcttgccagaagggcgtgctcgcaatcacaatcggccacagcaaat 1254
                 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 119545550 agatcgcttgataggcttgccagaagggcgtgctcgcaatcacaatcggccacagcaaat 119545609

                                                                             
Query: 1255      ccctgtcctggctggagtggtcatcgaagacgtggcagtcggagctgagcacacacttgc 1314
                 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 119545610 ccctgtcctggctggagtggtcatcgaagacgtggcagtcggagctgagcacacacttgc 119545669

                                                                     
Query: 1315      tttggcatcaactggagatgtgtatgcctgggggagcaattcagaagggcag 1366
                 ||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 119545670 tttggcatcaactggagatgtgtatgcctgggggagcaattcagaagggcag 119545721



 Score =  335 bits (169), Expect = 1e-88
 Identities = 169/169 (100%)
 Strand = Plus / Plus

                                                                             
Query: 1844      agaggacggaagtgtaagcccatctttgttcaaatagcgagacaagtagttaaactgaat 1903
                 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 119551321 agaggacggaagtgtaagcccatctttgttcaaatagcgagacaagtagttaaactgaat 119551380

                                                                             
Query: 1904      gcgtcagatctccgtctgccctcccgcgcatggaaggttaagctggttggagaaggggct 1963
                 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 119551381 gcgtcagatctccgtctgccctcccgcgcatggaaggttaagctggttggagaaggggct 119551440

                                                                  
Query: 1964      gatgatgctggaggagtgtttgatgacacgatcacagagatgtgccagg 2012
                 |||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 119551441 gatgatgctggaggagtgtttgatgacacgatcacagagatgtgccagg 119551489



 Score =  315 bits (159), Expect = 9e-83
 Identities = 159/159 (100%)
 Strand = Plus / Plus

                                                                             
Query: 813       agatgtcttgtggcttcaaacattcagcggtggtaacttcagatggcaaactctttacct 872
                 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 119541593 agatgtcttgtggcttcaaacattcagcggtggtaacttcagatggcaaactctttacct 119541652

                                                                             
Query: 873       ttgggaatggtgactacggtcgtctgggtcttggaaatacctccaacaaaaaacttccag 932
                 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 119541653 ttgggaatggtgactacggtcgtctgggtcttggaaatacctccaacaaaaaacttccag 119541712

                                                        
Query: 933       agagagtgactgcactagagggatatcagattggacagg 971
                 |||||||||||||||||||||||||||||||||||||||
Sbjct: 119541713 agagagtgactgcactagagggatatcagattggacagg 119541751



 Score =  313 bits (158), Expect = 4e-82
 Identities = 158/158 (100%)
 Strand = Plus / Plus

                                                                             
Query: 2340      agatgattcctcttgattcttttgttggccagagtgctgatggcaaaatggttcctataa 2399
                 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 119554207 agatgattcctcttgattcttttgttggccagagtgctgatggcaaaatggttcctataa 119554266

                                                                             
Query: 2400      tccctggtggaaatagtatcccactcacattttccaataggaaggaatatgtggagaggg 2459
                 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 119554267 tccctggtggaaatagtatcccactcacattttccaataggaaggaatatgtggagaggg 119554326

                                                       
Query: 2460      ccattgaatatcgacttcatgaaatggaccgacaggtg 2497
                 ||||||||||||||||||||||||||||||||||||||
Sbjct: 119554327 ccattgaatatcgacttcatgaaatggaccgacaggtg 119554364



 Score =  301 bits (152), Expect = 1e-78
 Identities = 166/173 (95%)
 Strand = Plus / Plus

                                                                             
Query: 1503      caggtgtgtcagtgcctctgcagctgggcctgcctgatgcagtgnnnnnnnagtacgggg 1562
                 ||||||||||||||||||||||||||||||||||||||||||||       |||||||||
Sbjct: 119549504 caggtgtgtcagtgcctctgcagctgggcctgcctgatgcagtgcccccccagtacgggg 119549563

                                                                             
Query: 1563      cgctgagggaggtgagcattcacactgcaagggccaggctccggctgctttaccacttct 1622
                 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 119549564 cgctgagggaggtgagcattcacactgcaagggccaggctccggctgctttaccacttct 119549623

                                                                      
Query: 1623      ctgacctcatgtactcgtcctggaggctactgaacctcagccccaataaccag 1675
                 |||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 119549624 ctgacctcatgtactcgtcctggaggctactgaacctcagccccaataaccag 119549676



 Score =  283 bits (143), Expect = 3e-73
 Identities = 143/143 (100%)
 Strand = Plus / Plus

                                                                             
Query: 491       caggtcatatgtggtcagaattgtacctttgtcatccaggccaatggcacagtgttggct 550
                 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 119539244 caggtcatatgtggtcagaattgtacctttgtcatccaggccaatggcacagtgttggct 119539303

                                                                             
Query: 551       tgtggggaaggaagttatggcagattaggacaaggaaattcagatgaccttcatgtgctg 610
                 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 119539304 tgtggggaaggaagttatggcagattaggacaaggaaattcagatgaccttcatgtgctg 119539363

                                        
Query: 611       acagttatttcagccttacaagg 633
                 |||||||||||||||||||||||
Sbjct: 119539364 acagttatttcagccttacaagg 119539386



 Score =  280 bits (141), Expect = 5e-72
 Identities = 144/145 (99%)
 Strand = Plus / Plus

                                                                             
Query: 1364      cagctcggcttaggtcacaccaaccacgttcgagaaccaaccctcgtaacagttctgcaa 1423
                 ||||| ||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 119547309 cagcttggcttaggtcacaccaaccacgttcgagaaccaaccctcgtaacagttctgcaa 119547368

                                                                             
Query: 1424      gggaaaaacgttcgacagatctcggccgggcgctgccacagtgctgcatggacagcccct 1483
                 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 119547369 gggaaaaacgttcgacagatctcggccgggcgctgccacagtgctgcatggacagcccct 119547428

                                          
Query: 1484      cccgtccctccaagagcgccaggtg 1508
                 |||||||||||||||||||||||||
Sbjct: 119547429 cccgtccctccaagagcgccaggtg 119547453



 Score =  258 bits (130), Expect = 2e-65
 Identities = 130/130 (100%)
 Strand = Plus / Plus

                                                                             
Query: 366       aggactggcacctgggaggtaaatgtgatgtctacctgtggggtgctggcaggcatggac 425
                 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 119538268 aggactggcacctgggaggtaaatgtgatgtctacctgtggggtgctggcaggcatggac 119538327

                                                                             
Query: 426       agctggcagaagctggaagaaatgtaatggtacctgcagcagctccctcattctcacaag 485
                 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 119538328 agctggcagaagctggaagaaatgtaatggtacctgcagcagctccctcattctcacaag 119538387

                           
Query: 486       cccaacaggt 495
                 ||||||||||
Sbjct: 119538388 cccaacaggt 119538397



 Score =  250 bits (126), Expect = 4e-63
 Identities = 126/126 (100%)
 Strand = Plus / Plus

                                                                             
Query: 968       caggtggcttgtggcttaaaccatactttggcagtatcagcagatggctccatggtgtgg 1027
                 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 119542476 caggtggcttgtggcttaaaccatactttggcagtatcagcagatggctccatggtgtgg 119542535

                                                                             
Query: 1028      gcttttggagatggcgactatggaaaactaggtttaggaaattccactgcaaaatcttca 1087
                 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 119542536 gcttttggagatggcgactatggaaaactaggtttaggaaattccactgcaaaatcttca 119542595

                       
Query: 1088      cctcag 1093
                 ||||||
Sbjct: 119542596 cctcag 119542601



 Score =  210 bits (106), Expect = 4e-51
 Identities = 106/106 (100%)
 Strand = Plus / Plus

                                                                             
Query: 1091      cagaaagtcgatgtcctttgtggaatcggaataaaaaaggttgcttgtggaactcagttt 1150
                 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 119543923 cagaaagtcgatgtcctttgtggaatcggaataaaaaaggttgcttgtggaactcagttt 119543982

                                                               
Query: 1151      tctgttgcattgactaaagatggtcatgtgtatacctttggtcaag 1196
                 ||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 119543983 tctgttgcattgactaaagatggtcatgtgtatacctttggtcaag 119544028



 Score =  163 bits (82), Expect = 8e-37
 Identities = 82/82 (100%)
 Strand = Plus / Plus

                                                                             
Query: 2009      caggaacttgaaactggtattgttgaccttcttataccctctccaaatgctactgcagaa 2068
                 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 119552300 caggaacttgaaactggtattgttgaccttcttataccctctccaaatgctactgcagaa 119552359

                                       
Query: 2069      gtgggttacaatagggacaggt 2090
                 ||||||||||||||||||||||
Sbjct: 119552360 gtgggttacaatagggacaggt 119552381



 Score =  135 bits (68), Expect = 2e-28
 Identities = 68/68 (100%)
 Strand = Plus / Plus

                                                                             
Query: 301       ggataacagtaaatggattaatggcatggatgaacaaattatgtcttgggcaacttcgag 360
                 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 119538030 ggataacagtaaatggattaatggcatggatgaacaaattatgtcttgggcaacttcgag 119538089

                         
Query: 361       acctgagg 368
                 ||||||||
Sbjct: 119538090 acctgagg 119538097


>gb|GL894430.2| Sus scrofa unplaced genomic scaffold ChrUScaf2314
          Length = 84245

 Score =  589 bits (297), Expect = e-165
 Identities = 297/297 (100%)
 Strand = Plus / Minus

                                                                         
Query: 6     agcctcatgtggtttgtggtgaccagcttgttcatagcccctatatgcaatgtctggctt 65
             ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 45837 agcctcatgtggtttgtggtgaccagcttgttcatagcccctatatgcaatgtctggctt 45778

                                                                         
Query: 66    cccttgctgtgggacttcatctggatcagctgctgtgtaaccctccagtgccaccacacc 125
             ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 45777 cccttgctgtgggacttcatctggatcagctgctgtgtaaccctccagtgccaccacacc 45718

                                                                         
Query: 126   accagaactgccttcctgaccctgcatcctggaatccaaatgagtgggcctggttagaat 185
             ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 45717 accagaactgccttcctgaccctgcatcctggaatccaaatgagtgggcctggttagaat 45658

                                                                         
Query: 186   gtttctcaaccaccataaaagccgctgaagccctgaccaatggagcacagtttccagaat 245
             ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 45657 gtttctcaaccaccataaaagccgctgaagccctgaccaatggagcacagtttccagaat 45598

                                                                      
Query: 246   cttttagtgttcccgatctagagcctgttccagaggatgaacttgtattcctaatgg 302
             |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 45597 cttttagtgttcccgatctagagcctgttccagaggatgaacttgtattcctaatgg 45541



 Score =  507 bits (256), Expect = e-140
 Identities = 256/256 (100%)
 Strand = Plus / Minus

                                                                         
Query: 2086  caggttcctttttaacccttctgcctgcctcgatgaacacttaatgcagtttaaattctt 2145
             ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 28649 caggttcctttttaacccttctgcctgcctcgatgaacacttaatgcagtttaaattctt 28590

                                                                         
Query: 2146  gggaattttaatgggggttgccattcgtacaaagaagcctctggacctccacttggcccc 2205
             ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 28589 gggaattttaatgggggttgccattcgtacaaagaagcctctggacctccacttggcccc 28530

                                                                         
Query: 2206  tctggtatggaagcagctgtgctgcgtcccactcaccctggaagacctggaggaggtgga 2265
             ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 28529 tctggtatggaagcagctgtgctgcgtcccactcaccctggaagacctggaggaggtgga 28470

                                                                         
Query: 2266  tctgctctatgtgcagactctcaacagcattcttcacattgaagacagtgggattactga 2325
             ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 28469 tctgctctatgtgcagactctcaacagcattcttcacattgaagacagtgggattactga 28410

                             
Query: 2326  ggagagtttccatgag 2341
             ||||||||||||||||
Sbjct: 28409 ggagagtttccatgag 28394



 Score =  365 bits (184), Expect = 1e-97
 Identities = 184/184 (100%)
 Strand = Plus / Minus

                                                                         
Query: 631   aggctttgtggtgacccagctggtgacttcctgtggttctgatgggcactccatggccct 690
             ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 41932 aggctttgtggtgacccagctggtgacttcctgtggttctgatgggcactccatggccct 41873

                                                                         
Query: 691   gactgaaagtggtgaggtctttagctggggagatggtgattatggcaaactcggccatgg 750
             ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 41872 gactgaaagtggtgaggtctttagctggggagatggtgattatggcaaactcggccatgg 41813

                                                                         
Query: 751   gaacagcgacaggcagcggcggcccaggcaaatcgaggccttacaaggagaagaagtggt 810
             ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 41812 gaacagcgacaggcagcggcggcccaggcaaatcgaggccttacaaggagaagaagtggt 41753

                 
Query: 811   gcag 814
             ||||
Sbjct: 41752 gcag 41749



 Score =  343 bits (173), Expect = 4e-91
 Identities = 173/173 (100%)
 Strand = Plus / Minus

                                                                         
Query: 1673  cagaatagtacatctcattataatgctggaacatggggcattgtgcagggacagcttcgg 1732
             ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 31232 cagaatagtacatctcattataatgctggaacatggggcattgtgcagggacagcttcgg 31173

                                                                         
Query: 1733  cctttgttagccccaagagtctacaccctcccaatggtgcgctctataggaaaaaccatg 1792
             ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 31172 cctttgttagccccaagagtctacaccctcccaatggtgcgctctataggaaaaaccatg 31113

                                                                  
Query: 1793  gttcaaggcaaaaactatggacctcaaattactgtaaagaggatatcaaccag 1845
             |||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 31112 gttcaaggcaaaaactatggacctcaaattactgtaaagaggatatcaaccag 31060



 Score =  341 bits (172), Expect = 2e-90
 Identities = 172/172 (100%)
 Strand = Plus / Minus

                                                                         
Query: 1195  agatcgcttgataggcttgccagaagggcgtgctcgcaatcacaatcggccacagcaaat 1254
             ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 36661 agatcgcttgataggcttgccagaagggcgtgctcgcaatcacaatcggccacagcaaat 36602

                                                                         
Query: 1255  ccctgtcctggctggagtggtcatcgaagacgtggcagtcggagctgagcacacacttgc 1314
             ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 36601 ccctgtcctggctggagtggtcatcgaagacgtggcagtcggagctgagcacacacttgc 36542

                                                                 
Query: 1315  tttggcatcaactggagatgtgtatgcctgggggagcaattcagaagggcag 1366
             ||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 36541 tttggcatcaactggagatgtgtatgcctgggggagcaattcagaagggcag 36490



 Score =  335 bits (169), Expect = 1e-88
 Identities = 169/169 (100%)
 Strand = Plus / Minus

                                                                         
Query: 1844  agaggacggaagtgtaagcccatctttgttcaaatagcgagacaagtagttaaactgaat 1903
             ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 30796 agaggacggaagtgtaagcccatctttgttcaaatagcgagacaagtagttaaactgaat 30737

                                                                         
Query: 1904  gcgtcagatctccgtctgccctcccgcgcatggaaggttaagctggttggagaaggggct 1963
             ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 30736 gcgtcagatctccgtctgccctcccgcgcatggaaggttaagctggttggagaaggggct 30677

                                                              
Query: 1964  gatgatgctggaggagtgtttgatgacacgatcacagagatgtgccagg 2012
             |||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 30676 gatgatgctggaggagtgtttgatgacacgatcacagagatgtgccagg 30628



 Score =  315 bits (159), Expect = 9e-83
 Identities = 159/159 (100%)
 Strand = Plus / Minus

                                                                         
Query: 813   agatgtcttgtggcttcaaacattcagcggtggtaacttcagatggcaaactctttacct 872
             ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 40778 agatgtcttgtggcttcaaacattcagcggtggtaacttcagatggcaaactctttacct 40719

                                                                         
Query: 873   ttgggaatggtgactacggtcgtctgggtcttggaaatacctccaacaaaaaacttccag 932
             ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 40718 ttgggaatggtgactacggtcgtctgggtcttggaaatacctccaacaaaaaacttccag 40659

                                                    
Query: 933   agagagtgactgcactagagggatatcagattggacagg 971
             |||||||||||||||||||||||||||||||||||||||
Sbjct: 40658 agagagtgactgcactagagggatatcagattggacagg 40620



 Score =  313 bits (158), Expect = 4e-82
 Identities = 158/158 (100%)
 Strand = Plus / Minus

                                                                         
Query: 2340  agatgattcctcttgattcttttgttggccagagtgctgatggcaaaatggttcctataa 2399
             ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 27910 agatgattcctcttgattcttttgttggccagagtgctgatggcaaaatggttcctataa 27851

                                                                         
Query: 2400  tccctggtggaaatagtatcccactcacattttccaataggaaggaatatgtggagaggg 2459
             ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 27850 tccctggtggaaatagtatcccactcacattttccaataggaaggaatatgtggagaggg 27791

                                                   
Query: 2460  ccattgaatatcgacttcatgaaatggaccgacaggtg 2497
             ||||||||||||||||||||||||||||||||||||||
Sbjct: 27790 ccattgaatatcgacttcatgaaatggaccgacaggtg 27753



 Score =  301 bits (152), Expect = 1e-78
 Identities = 166/173 (95%)
 Strand = Plus / Minus

                                                                         
Query: 1503  caggtgtgtcagtgcctctgcagctgggcctgcctgatgcagtgnnnnnnnagtacgggg 1562
             ||||||||||||||||||||||||||||||||||||||||||||       |||||||||
Sbjct: 32697 caggtgtgtcagtgcctctgcagctgggcctgcctgatgcagtgcccccccagtacgggg 32638

                                                                         
Query: 1563  cgctgagggaggtgagcattcacactgcaagggccaggctccggctgctttaccacttct 1622
             ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 32637 cgctgagggaggtgagcattcacactgcaagggccaggctccggctgctttaccacttct 32578

                                                                  
Query: 1623  ctgacctcatgtactcgtcctggaggctactgaacctcagccccaataaccag 1675
             |||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 32577 ctgacctcatgtactcgtcctggaggctactgaacctcagccccaataaccag 32525



 Score =  283 bits (143), Expect = 3e-73
 Identities = 143/143 (100%)
 Strand = Plus / Minus

                                                                         
Query: 491   caggtcatatgtggtcagaattgtacctttgtcatccaggccaatggcacagtgttggct 550
             ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 43127 caggtcatatgtggtcagaattgtacctttgtcatccaggccaatggcacagtgttggct 43068

                                                                         
Query: 551   tgtggggaaggaagttatggcagattaggacaaggaaattcagatgaccttcatgtgctg 610
             ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 43067 tgtggggaaggaagttatggcagattaggacaaggaaattcagatgaccttcatgtgctg 43008

                                    
Query: 611   acagttatttcagccttacaagg 633
             |||||||||||||||||||||||
Sbjct: 43007 acagttatttcagccttacaagg 42985



 Score =  280 bits (141), Expect = 5e-72
 Identities = 144/145 (99%)
 Strand = Plus / Minus

                                                                         
Query: 1364  cagctcggcttaggtcacaccaaccacgttcgagaaccaaccctcgtaacagttctgcaa 1423
             ||||| ||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 34902 cagcttggcttaggtcacaccaaccacgttcgagaaccaaccctcgtaacagttctgcaa 34843

                                                                         
Query: 1424  gggaaaaacgttcgacagatctcggccgggcgctgccacagtgctgcatggacagcccct 1483
             ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 34842 gggaaaaacgttcgacagatctcggccgggcgctgccacagtgctgcatggacagcccct 34783

                                      
Query: 1484  cccgtccctccaagagcgccaggtg 1508
             |||||||||||||||||||||||||
Sbjct: 34782 cccgtccctccaagagcgccaggtg 34758



 Score =  258 bits (130), Expect = 2e-65
 Identities = 130/130 (100%)
 Strand = Plus / Minus

                                                                         
Query: 366   aggactggcacctgggaggtaaatgtgatgtctacctgtggggtgctggcaggcatggac 425
             ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 44103 aggactggcacctgggaggtaaatgtgatgtctacctgtggggtgctggcaggcatggac 44044

                                                                         
Query: 426   agctggcagaagctggaagaaatgtaatggtacctgcagcagctccctcattctcacaag 485
             ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 44043 agctggcagaagctggaagaaatgtaatggtacctgcagcagctccctcattctcacaag 43984

                       
Query: 486   cccaacaggt 495
             ||||||||||
Sbjct: 43983 cccaacaggt 43974



 Score =  250 bits (126), Expect = 4e-63
 Identities = 126/126 (100%)
 Strand = Plus / Minus

                                                                         
Query: 968   caggtggcttgtggcttaaaccatactttggcagtatcagcagatggctccatggtgtgg 1027
             ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 39735 caggtggcttgtggcttaaaccatactttggcagtatcagcagatggctccatggtgtgg 39676

                                                                         
Query: 1028  gcttttggagatggcgactatggaaaactaggtttaggaaattccactgcaaaatcttca 1087
             ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 39675 gcttttggagatggcgactatggaaaactaggtttaggaaattccactgcaaaatcttca 39616

                   
Query: 1088  cctcag 1093
             ||||||
Sbjct: 39615 cctcag 39610



 Score =  210 bits (106), Expect = 4e-51
 Identities = 106/106 (100%)
 Strand = Plus / Minus

                                                                         
Query: 1091  cagaaagtcgatgtcctttgtggaatcggaataaaaaaggttgcttgtggaactcagttt 1150
             ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 38288 cagaaagtcgatgtcctttgtggaatcggaataaaaaaggttgcttgtggaactcagttt 38229

                                                           
Query: 1151  tctgttgcattgactaaagatggtcatgtgtatacctttggtcaag 1196
             ||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 38228 tctgttgcattgactaaagatggtcatgtgtatacctttggtcaag 38183



 Score =  163 bits (82), Expect = 8e-37
 Identities = 82/82 (100%)
 Strand = Plus / Minus

                                                                         
Query: 2009  caggaacttgaaactggtattgttgaccttcttataccctctccaaatgctactgcagaa 2068
             ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 29817 caggaacttgaaactggtattgttgaccttcttataccctctccaaatgctactgcagaa 29758

                                   
Query: 2069  gtgggttacaatagggacaggt 2090
             ||||||||||||||||||||||
Sbjct: 29757 gtgggttacaatagggacaggt 29736



 Score =  135 bits (68), Expect = 2e-28
 Identities = 68/68 (100%)
 Strand = Plus / Minus

                                                                         
Query: 301   ggataacagtaaatggattaatggcatggatgaacaaattatgtcttgggcaacttcgag 360
             ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 44341 ggataacagtaaatggattaatggcatggatgaacaaattatgtcttgggcaacttcgag 44282

                     
Query: 361   acctgagg 368
             ||||||||
Sbjct: 44281 acctgagg 44274


  Database: Sscrofa_10.2.fasta
    Posted date:  Nov 16, 2011 10:34 AM
  Number of letters in database: 2,808,509,378
  Number of sequences in database:  4582
  
Lambda     K      H
    1.37    0.711     1.31 

Gapped
Lambda     K      H
    1.37    0.711     1.31 


Matrix: blastn matrix:1 -3
Gap Penalties: Existence: 5, Extension: 2
Number of Sequences: 4582
Number of Hits to DB: 103,939,270
Number of extensions: 194
Number of successful extensions: 194
Number of sequences better than 1.0e-05: 2
Number of HSP's gapped: 192
Number of HSP's successfully gapped: 34
Length of query: 3506
Length of database: 2,808,509,378
Length adjustment: 22
Effective length of query: 3484
Effective length of database: 2,808,408,574
Effective search space: 9784495471816
Effective search space used: 9784495471816
X1: 11 (21.8 bits)
X2: 15 (29.7 bits)
X3: 50 (99.1 bits)
S1: 19 (38.2 bits)
S2: 30 (60.0 bits)