Animal-Genome cDNA 20110601C-004015

BLASTX 2.2.24 [Aug-08-2010]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= 20110601C-004015
         (1263 letters)

Database: RefSeq49_BP.fasta 
           33,088 sequences; 17,681,374 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

Alignment   gi|NP_001069489.1| secretion-regulating guanine nucleotide exch...   673   0.0  
Alignment   gi|NP_001077132.1| probable E3 ubiquitin-protein ligase HERC3 [...   133   4e-31
Alignment   gi|NP_001193010.1| probable E3 ubiquitin-protein ligase HERC2 [...   125   6e-29
Alignment   gi|XP_002685237.1| PREDICTED: hect domain and RLD 3-like [Bos t...   125   6e-29
Alignment   gi|NP_001070362.2| hect domain and RLD 4 [Bos taurus].               122   5e-28
Alignment   gi|NP_001179920.1| RCC1 and BTB domain-containing protein 2 [Bo...   107   2e-23
Alignment   gi|XP_002691829.1| PREDICTED: regulator of chromosome condensat...   107   2e-23
Alignment   gi|NP_001178141.1| RCC1 and BTB domain-containing protein 1 [Bo...   103   4e-22
Alignment   gi|XP_002691834.1| PREDICTED: regulator of chromosome condensat...   103   4e-22
Alignment   gi|NP_001179573.1| probable E3 ubiquitin-protein ligase HERC6 [...   102   9e-22

>ref|NP_001069489.1| secretion-regulating guanine nucleotide exchange factor [Bos taurus].
          Length = 464

 Score =  673 bits (1736), Expect = 0.0
 Identities = 322/399 (80%), Positives = 342/399 (85%)
 Frame = +2

Query: 53   ALFAWGANSYGQLGLGHKEDVLLPQQLSEFCKPGCVKRITGGGGHSAIVTDQGSLFVCGL 232
            ALFAWGANSYGQLGLGHKEDVL  QQLS+FCK GC+KRITGGGGHSA+VTD+GSLFVCGL
Sbjct: 16   ALFAWGANSYGQLGLGHKEDVLSAQQLSDFCKSGCIKRITGGGGHSAVVTDEGSLFVCGL 75

Query: 233  NKDGQLGLGHTEDVLYFTLCKSLLGCPIQQVACGWDFTIILTKNGQVLSCGSNSFGQLGV 412
            NKDGQLGLGHTE+VLYFT CKSLLGC IQQVACGWDFTIILT+NGQVLSCGSNSFGQLGV
Sbjct: 76   NKDGQLGLGHTEEVLYFTPCKSLLGCAIQQVACGWDFTIILTENGQVLSCGSNSFGQLGV 135

Query: 413  PHGPRRCVVPQAIEVQREKVVSIXXXXXXXXXXXXSGLVFQWGTGLASSGRRLCPGQTLP 592
            PHGPRRCV+PQAIE+ REKVVSI            SG VFQWGTGLASSGRRLCPGQTLP
Sbjct: 136  PHGPRRCVIPQAIELLREKVVSIAAGLRHALAATASGTVFQWGTGLASSGRRLCPGQTLP 195

Query: 593  LFLTAKEPSKVTGLENSQAVCVLAGSGHSASLTDAGELYVWGSNKHGQLASQAAFLPLPQ 772
            LFLTAKEPS VTGLENSQAVCVLAGS HSASLTDAGELYVWGSNKHGQLASQAAFL LPQ
Sbjct: 196  LFLTAKEPSTVTGLENSQAVCVLAGSDHSASLTDAGELYVWGSNKHGQLASQAAFLLLPQ 255

Query: 773  KIEAHRFQNEKVAAVWSGWTHLVAQTETGKVFTWGRADYGQLGRTLESPEGWKPKKQASS 952
            +IEA  FQNEK+AAVWSGWTHLVAQT TGKVFTWGRADYGQLGRT+E+ EGW+ +KQ  S
Sbjct: 256  RIEARCFQNEKIAAVWSGWTHLVAQTVTGKVFTWGRADYGQLGRTVETREGWESEKQDPS 315

Query: 953  LPCSRPARSVPSSLPCLTGATEVSCGSEHNLAVVGGTCYSWGWNEHGMCGDGTEANVWTP 1132
            LP S P +  PS LPCLTGATE+SCGSEHNLAV+GG C+SWGWNEHGMCGDGTEA+VW P
Sbjct: 316  LPGSGPQKGTPSCLPCLTGATEISCGSEHNLAVIGGVCHSWGWNEHGMCGDGTEADVWAP 375

Query: 1133 KPVQALRSSSGLRLGCGAGHSXXXXXXXXXXXXGQRPRV 1249
            KPV  LR   GL +GCGAGHS            GQ P V
Sbjct: 376  KPVPGLRFFLGLHVGCGAGHSLALCQLPALPALGQHPSV 414


>ref|NP_001077132.1| probable E3 ubiquitin-protein ligase HERC3 [Bos taurus].
          Length = 1050

 Score =  133 bits (334), Expect = 4e-31
 Identities = 105/368 (28%), Positives = 163/368 (44%), Gaps = 5/368 (1%)
 Frame = +2

Query: 56   LFAWGANSYGQLGLG-HKEDVLLPQQLSEFCKPGCVKRITGGGGHSAIVTDQGSLFVCGL 232
            +  WG  S GQ G+  + + ++   Q+  F     VK +  GG HS  + + G ++ CG+
Sbjct: 1    MLCWGYWSLGQPGISPNLQGIVAEPQVCGFISDRSVKEVACGGNHSVFLLEDGEVYTCGV 60

Query: 233  NKDGQLGLGHTEDVLYFTLCKSLLGCPIQQVACGWDFTIILTKNGQVLSCGSNSFGQLGV 412
            N  GQ  LGH  +        +L    I  VACG   ++ L+  GQ+ S G+ S GQLG+
Sbjct: 61   NTKGQ--LGHEREGNKPEQIGALADQHIVHVACGESHSLALSDQGQLFSWGAGSDGQLGL 118

Query: 413  PHGPRRCVVPQAIE-VQREKVVSIXXXXXXXXXXXXSGLVFQWGTGLASSGRRLCPGQTL 589
                    VP+ I+ + ++ ++ +             G  F WG    +S  +L  G+  
Sbjct: 119  MTIEDSVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWG---RNSHGQLGLGKEF 175

Query: 590  PLFLTAKEPSKVTGLENSQAVCVLAGSGHSASLTDAGELYVWGSNKHGQLA-SQAAFLPL 766
            P   +   P +V  LE      V+AG  HS +L+ +G ++ WG N  GQL  S       
Sbjct: 176  P---SQASPQRVRSLEGIPLAQVVAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEKDRES 232

Query: 767  PQKIEAHRFQNEKVAAVWSGWTHLVAQTETGKVFTWGRADYGQLGRTLESPEGWKPKKQA 946
            P  ++  R Q  KV  +  G  H    T++G VFT+G    GQLG    + E   P++  
Sbjct: 233  PCHVKLLRTQ--KVVYISCGEEHTAVLTKSGGVFTFGAGSCGQLGHDSMNDE-VNPRRVL 289

Query: 947  SSLPCSRPARSVPSSLPCLTGATEVSCGSEHNLAVV--GGTCYSWGWNEHGMCGDGTEAN 1120
              +                +  T+++CG +H LA V   G  Y++G    G  G G   N
Sbjct: 290  ELMG---------------SEVTQIACGRQHTLAFVPSSGLIYAFGCGARGQLGTGHTCN 334

Query: 1121 VWTPKPVQ 1144
            V  P PV+
Sbjct: 335  VKCPSPVK 342



 Score = 92.4 bits (228), Expect = 7e-19
 Identities = 74/304 (24%), Positives = 124/304 (40%), Gaps = 1/304 (0%)
 Frame = +2

Query: 287  LCKSLLGCPIQQVACGWDFTIILTKNGQVLSCGSNSFGQLGVPHGPRRCVVPQAIEVQRE 466
            +C  +    +++VACG + ++ L ++G+V +CG N+ GQLG  H        Q   +  +
Sbjct: 27   VCGFISDRSVKEVACGGNHSVFLLEDGEVYTCGVNTKGQLG--HEREGNKPEQIGALADQ 84

Query: 467  KVVSIXXXXXXXXXXXXSGLVFQWGTGLASSGRRLCPGQTLPLFLTAKEPSKVTGLENSQ 646
             +V +             G +F WG G  S G+       + +  +   P  +  L    
Sbjct: 85   HIVHVACGESHSLALSDQGQLFSWGAG--SDGQL----GLMTIEDSVAVPRLIQKLNQQT 138

Query: 647  AVCVLAGSGHSASLTDAGELYVWGSNKHGQLASQAAFLPLPQKIEAHRFQNEKVAAVWSG 826
             + V  G+ H  +L   G+ + WG N HGQL     F            +   +A V +G
Sbjct: 139  ILQVSCGNWHCLALAADGQFFTWGRNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVVAG 198

Query: 827  WTHLVAQTETGKVFTWGRADYGQLGRTLESPEGWKPKKQASSLPCSRPARSVPSSLPCLT 1006
              H  A + +G VF WG  + GQLG + E     K ++    +   R  + V        
Sbjct: 199  GAHSFALSLSGAVFGWGMNNAGQLGLSDE-----KDRESPCHVKLLRTQKVV-------- 245

Query: 1007 GATEVSCGSEHNLAVV-GGTCYSWGWNEHGMCGDGTEANVWTPKPVQALRSSSGLRLGCG 1183
                +SCG EH   +   G  +++G    G  G  +  +   P+ V  L  S   ++ CG
Sbjct: 246  ---YISCGEEHTAVLTKSGGVFTFGAGSCGQLGHDSMNDEVNPRRVLELMGSEVTQIACG 302

Query: 1184 AGHS 1195
              H+
Sbjct: 303  RQHT 306



 Score = 65.1 bits (157), Expect = 1e-10
 Identities = 40/123 (32%), Positives = 62/123 (50%), Gaps = 1/123 (0%)
 Frame = +2

Query: 53  ALFAWGANSYGQLGLGHKEDVLLPQQLSEFCKPGCVKRITGGGGHSAIVTDQGSLFVCGL 232
           A+F WG N+ GQLGL  ++D   P  + +  +   V  I+ G  H+A++T  G +F  G 
Sbjct: 210 AVFGWGMNNAGQLGLSDEKDRESPCHV-KLLRTQKVVYISCGEEHTAVLTKSGGVFTFGA 268

Query: 233 NKDGQLGLGHTEDVLYFTLCKSLLGCPIQQVACGWDFTI-ILTKNGQVLSCGSNSFGQLG 409
              GQLG     D +       L+G  + Q+ACG   T+  +  +G + + G  + GQLG
Sbjct: 269 GSCGQLGHDSMNDEVNPRRVLELMGSEVTQIACGRQHTLAFVPSSGLIYAFGCGARGQLG 328

Query: 410 VPH 418
             H
Sbjct: 329 TGH 331


>ref|NP_001193010.1| probable E3 ubiquitin-protein ligase HERC2 [Bos taurus].
          Length = 4837

 Score =  125 bits (315), Expect = 6e-29
 Identities = 117/390 (30%), Positives = 171/390 (43%), Gaps = 10/390 (2%)
 Frame = +2

Query: 56   LFAWGANSYGQLG--LGHKEDVLLPQQLSEFCKPGCVKRITGGGGHSAIVTDQGSLFVCG 229
            ++ WG N  GQLG   G K  V  P +     +P    ++ GG      VT  G L+  G
Sbjct: 3957 IYGWGHNHRGQLGGIEGAKVKVPTPCEALAALRP---VQLIGGEQTLFAVTADGKLYATG 4013

Query: 230  LNKDGQLGLGHTEDVLYFTLCKSLLGCPIQQVAC--GWDFTIILTKNGQVLSCGSNSFGQ 403
                G+LG+G TE V   TL +S+    I++VA   G    + L+  G+V S G    G+
Sbjct: 4014 YGAGGRLGVGGTESVSTPTLLESIQHVFIKKVAVNSGGKHCLALSSEGEVYSWGEAEDGK 4073

Query: 404  LGVPHGPRR-CVVPQAIEVQR-EKVVSIXXXXXXXXXXXXSGLVFQWGTG-LASSGRRLC 574
            LG  HG R  C  P+ IE  R  +VV +            +G ++ WG G     G    
Sbjct: 4074 LG--HGNRSPCDRPRVIESLRGTEVVDVAAGGAHSACVTAAGDLYTWGKGRYGRLGHSDS 4131

Query: 575  PGQTLPLFLTAKEPSKVTGLENSQAVCVLAGSGHSASL--TDAGELYVWGSNKHGQLASQ 748
              Q         +P  V  L+  + V V  GSG + +L  TD   ++ WG   +G+L   
Sbjct: 4132 EDQL--------KPKLVEALQGHRVVDVACGSGDAQTLCLTDDDTVWSWGDGDYGKLGRG 4183

Query: 749  AAF-LPLPQKIEAHRFQNEKVAAVWSGWTHLVAQTETGKVFTWGRADYGQLGRTLESPEG 925
             +    +P KI++       V  V  G    VA T++G V+TWG+ DY +LG    S + 
Sbjct: 4184 GSDGCKVPMKIDS--LTGLGVVKVECGSQFSVALTKSGAVYTWGKGDYHRLGHG--SDDH 4239

Query: 926  WKPKKQASSLPCSRPARSVPSSLPCLTGATEVSCGSEHNLAVVGGTCYSWGWNEHGMCGD 1105
             +  +Q   L   +       SL C+       C SE       G  Y+WG N+ G  GD
Sbjct: 4240 VRRPRQVQGLQGKKVIAIATGSLHCV-------CCSED------GEVYTWGDNDEGQLGD 4286

Query: 1106 GTEANVWTPKPVQALRSSSGLRLGCGAGHS 1195
            GT   +  P+ V AL+     R+ CG+ H+
Sbjct: 4287 GTTNAIQRPRLVAALQGKKVNRVACGSAHT 4316



 Score =  119 bits (298), Expect = 6e-27
 Identities = 117/398 (29%), Positives = 167/398 (41%), Gaps = 16/398 (4%)
 Frame = +2

Query: 50   TALFAWGANSYGQLGLGHKEDVLLPQQLSEFCKPGCVKRITGGGGHSAIVTDQGSLFVCG 229
            T +F WG N   QLG G K   +     SE      V ++ GG      VT +G ++ CG
Sbjct: 2960 TKVFVWGLNDKDQLG-GLKGSKIKVPSFSETLSALNVVQVAGGSKSLFAVTVEGKVYACG 3018

Query: 230  LNKDGQLGLGHTEDVLYFTL-CKSLLGCPIQQVAC--GWDFTIILTKNGQVLSCGSNSFG 400
               +G+LGLG +   +       +L    +++VA   G      LT +G+V S G    G
Sbjct: 3019 EATNGRLGLGISSGTVPIPRQITALSSYVVKKVAVHSGGRHATALTVDGKVFSWGEGDDG 3078

Query: 401  QLGVPHGPR-RCVVPQAIEVQREKVV-SIXXXXXXXXXXXXSGLVFQWGTGLASSGRRLC 574
            +LG  H  R  C  P+ IE  + K +  I            SG ++ WG G      RL 
Sbjct: 3079 KLG--HFSRMNCDKPRLIEALKTKRIRDIACGSSHSAALTSSGELYTWGLGEYG---RLG 3133

Query: 575  PGQTLPLFLTAKEPSKVTGLENSQAVCVLAGS--GHSASLTDAGELYVWGSNKHGQLASQ 748
             G       T  +P  V  L   + + V  GS    + +LTD G ++ WG    G+L   
Sbjct: 3134 HGDNT----TQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFSWGDGDFGKLGRG 3189

Query: 749  AAF-LPLPQKIEAHRFQNEKVAAVWSGWTHLVAQTETGKVFTWGRADYGQLG-------R 904
             +    +PQ IE  R   + V  +  G    +A T++G V+TWG+ DY +LG       R
Sbjct: 3190 GSEGCNIPQNIE--RLNGQGVCQIECGAQFSLALTKSGVVWTWGKGDYFRLGHGSDVHVR 3247

Query: 905  TLESPEGWKPKKQASSLPCSRPARSVPSSLPCLTGATEVSCGSEHNLAVV-GGTCYSWGW 1081
              +  EG + KK                          V+ G+ H LAV   G  Y+WG 
Sbjct: 3248 KPQVVEGLRGKK-----------------------IVHVAVGALHCLAVTDAGQVYAWGD 3284

Query: 1082 NEHGMCGDGTEANVWTPKPVQALRSSSGLRLGCGAGHS 1195
            N+HG  G+GT      P  VQ L      R+ CG+ HS
Sbjct: 3285 NDHGQQGNGTTTVNRKPTLVQGLEGQKITRVACGSSHS 3322



 Score =  114 bits (284), Expect = 2e-25
 Identities = 88/268 (32%), Positives = 126/268 (47%), Gaps = 3/268 (1%)
 Frame = +2

Query: 56   LFAWGANSYGQLGLGHKEDVLLPQQLSEFCKPGCVKRITGGGGHSAIVTDQGSLFVCGLN 235
            +F+WG    G+LG   + +   P+ L E  K   ++ I  G  HSA +T  G L+  GL 
Sbjct: 3069 VFSWGEGDDGKLGHFSRMNCDKPR-LIEALKTKRIRDIACGSSHSAALTSSGELYTWGLG 3127

Query: 236  KDGQLGLGHTEDVLYFTLCKSLLGCPIQQVACGWDF--TIILTKNGQVLSCGSNSFGQLG 409
            + G+LG G     L   + K LLG  + QVACG     T+ LT  G V S G   FG+LG
Sbjct: 3128 EYGRLGHGDNTTQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFSWGDGDFGKLG 3187

Query: 410  VPHGPRRCVVPQAIE-VQREKVVSIXXXXXXXXXXXXSGLVFQWGTGLASSGRRLCPGQT 586
               G   C +PQ IE +  + V  I            SG+V+ WG G      RL  G  
Sbjct: 3188 -RGGSEGCNIPQNIERLNGQGVCQIECGAQFSLALTKSGVVWTWGKG---DYFRLGHGSD 3243

Query: 587  LPLFLTAKEPSKVTGLENSQAVCVLAGSGHSASLTDAGELYVWGSNKHGQLASQAAFLPL 766
            + +    ++P  V GL   + V V  G+ H  ++TDAG++Y WG N HGQ  +    +  
Sbjct: 3244 VHV----RKPQVVEGLRGKKIVHVAVGALHCLAVTDAGQVYAWGDNDHGQQGNGTTTVNR 3299

Query: 767  PQKIEAHRFQNEKVAAVWSGWTHLVAQT 850
               +     + +K+  V  G +H VA T
Sbjct: 3300 KPTL-VQGLEGQKITRVACGSSHSVAWT 3326



 Score =  110 bits (274), Expect = 3e-24
 Identities = 91/348 (26%), Positives = 148/348 (42%), Gaps = 11/348 (3%)
 Frame = +2

Query: 182  GHSAIVTDQGSLFVCGLNKDGQLGLGHTEDVLYFTLCKSLLGCPIQQVACGWDFTIILTK 361
            G  +  T +  +FV GLN   QLG      +   +  ++L    + QVA G      +T 
Sbjct: 2951 GLESAATIRTKVFVWGLNDKDQLGGLKGSKIKVPSFSETLSALNVVQVAGGSKSLFAVTV 3010

Query: 362  NGQVLSCGSNSFGQLGVPHGPRRCVVPQAIEVQRE---KVVSIXXXXXXXXXXXXSGLVF 532
             G+V +CG  + G+LG+        +P+ I        K V++             G VF
Sbjct: 3011 EGKVYACGEATNGRLGLGISSGTVPIPRQITALSSYVVKKVAVHSGGRHATALTVDGKVF 3070

Query: 533  QWGTG----LASSGRRLCPGQTLPLFLTAKEPSKVTGLENSQAVCVLAGSGHSASLTDAG 700
             WG G    L    R  C            +P  +  L+  +   +  GS HSA+LT +G
Sbjct: 3071 SWGEGDDGKLGHFSRMNC-----------DKPRLIEALKTKRIRDIACGSSHSAALTSSG 3119

Query: 701  ELYVWGSNKHGQLASQAAFLPL-PQKIEAHRFQNEKVAAVWSGWTHLVAQTETGKVFTWG 877
            ELY WG  ++G+L        L P+ ++          A  S     +A T+ G VF+WG
Sbjct: 3120 ELYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFSWG 3179

Query: 878  RADYGQLGRTLESPEGWKPKKQASSLPCSRPARSVPSSLPCLT--GATEVSCGSEHNLAV 1051
              D+G+LGR               S  C     ++P ++  L   G  ++ CG++ +LA+
Sbjct: 3180 DGDFGKLGR-------------GGSEGC-----NIPQNIERLNGQGVCQIECGAQFSLAL 3221

Query: 1052 V-GGTCYSWGWNEHGMCGDGTEANVWTPKPVQALRSSSGLRLGCGAGH 1192
               G  ++WG  ++   G G++ +V  P+ V+ LR    + +  GA H
Sbjct: 3222 TKSGVVWTWGKGDYFRLGHGSDVHVRKPQVVEGLRGKKIVHVAVGALH 3269



 Score =  108 bits (269), Expect = 1e-23
 Identities = 90/326 (27%), Positives = 143/326 (43%), Gaps = 9/326 (2%)
 Frame = +2

Query: 242  GQLGLGHTEDVLYFTLCKSLLGCPIQQVACGWDFTIILTKNGQVLSCGSNSFGQLGVPHG 421
            G +G  +  +V+    C+ L    + Q+AC     +IL++NG+V +   NS         
Sbjct: 430  GLIGWKYYANVIGPIQCEGLANLGVTQIACAEKRFLILSRNGRVYTQAYNS--------- 480

Query: 422  PRRCVVPQAIE-VQREKVVSIXXXXXXXXXXXXS--GLVFQWGTGLASSGRRLCPGQTLP 592
                + PQ ++ +    +V I            +  G V+ WG G    G RL  G T+P
Sbjct: 481  --DTLAPQLVQGLASRNIVKIAAHSDGHHYLALAATGEVYSWGCG---DGGRLGHGDTVP 535

Query: 593  LFLTAKEPSKVTGLENSQA----VCVLAGSGHSASLTDAGELYVWGSNKHGQLA-SQAAF 757
            L    +EP  ++     QA    V +  GS +SA++T  GELY WG   +G+L    +  
Sbjct: 536  L----EEPKVISAFSGKQAGKHVVHIACGSTYSAAITAEGELYTWGRGNYGRLGHGSSED 591

Query: 758  LPLPQKIEAHRFQNEKVAAVWSGWTHLVAQTETGKVFTWGRADYGQLGRTLESPEGWKPK 937
              +P  +   +       A  SG    +A TE G+V++WG  DYG+LGR     +G K  
Sbjct: 592  EAIPMLVAGLKGLKVIDVACGSGDAQTLAVTENGQVWSWGDGDYGKLGR--GGSDGCKTP 649

Query: 938  KQASSLPCSRPARSVPSSLPCLTGATEVSCGSEHNLAVV-GGTCYSWGWNEHGMCGDGTE 1114
            K    L                    +V CGS+ ++A+   G  YSWG  ++   G GTE
Sbjct: 650  KLIEKLQD--------------LDVVKVRCGSQFSVALTKDGQVYSWGKGDNQRLGHGTE 695

Query: 1115 ANVWTPKPVQALRSSSGLRLGCGAGH 1192
             +V  PK ++ L+    + +  G+ H
Sbjct: 696  EHVRYPKLLEGLQGKKVIDVAAGSTH 721



 Score =  101 bits (252), Expect = 1e-21
 Identities = 82/267 (30%), Positives = 122/267 (45%), Gaps = 4/267 (1%)
 Frame = +2

Query: 56   LFAWGANSYGQLGLGHKEDVLLPQQLSEFCKPGCVKRITGGGGHSAIVTDQGSLFVCGLN 235
            +++WG    G+LG G++     P+ + E  +   V  +  GG HSA VT  G L+  G  
Sbjct: 4063 VYSWGEAEDGKLGHGNRSPCDRPRVI-ESLRGTEVVDVAAGGAHSACVTAAGDLYTWGKG 4121

Query: 236  KDGQLGLGHTEDVLYFTLCKSLLGCPIQQVACGWD--FTIILTKNGQVLSCGSNSFGQLG 409
            + G+LG   +ED L   L ++L G  +  VACG     T+ LT +  V S G   +G+LG
Sbjct: 4122 RYGRLGHSDSEDQLKPKLVEALQGHRVVDVACGSGDAQTLCLTDDDTVWSWGDGDYGKLG 4181

Query: 410  VPHGPRRCVVPQAIE-VQREKVVSIXXXXXXXXXXXXSGLVFQWGTGLASSGRRLCPGQT 586
               G   C VP  I+ +    VV +            SG V+ WG G      RL  G  
Sbjct: 4182 -RGGSDGCKVPMKIDSLTGLGVVKVECGSQFSVALTKSGAVYTWGKG---DYHRLGHGSD 4237

Query: 587  LPLFLTAKEPSKVTGLENSQAVCVLAGSGHSASLTDAGELYVWGSNKHGQLASQAA-FLP 763
              +    + P +V GL+  + + +  GS H    ++ GE+Y WG N  GQL       + 
Sbjct: 4238 DHV----RRPRQVQGLQGKKVIAIATGSLHCVCCSEDGEVYTWGDNDEGQLGDGTTNAIQ 4293

Query: 764  LPQKIEAHRFQNEKVAAVWSGWTHLVA 844
             P+ + A   Q +KV  V  G  H +A
Sbjct: 4294 RPRLVAA--LQGKKVNRVACGSAHTLA 4318



 Score = 97.8 bits (242), Expect = 2e-20
 Identities = 73/233 (31%), Positives = 108/233 (46%), Gaps = 6/233 (2%)
 Frame = +2

Query: 56   LFAWGANSYGQLGLGHKEDVLLPQQLSEFCKPGCVKRITG---GGGHSAIVTDQGSLFVC 226
            +++WG    G+LG G    +  P+ +S F      K +     G  +SA +T +G L+  
Sbjct: 517  VYSWGCGDGGRLGHGDTVPLEEPKVISAFSGKQAGKHVVHIACGSTYSAAITAEGELYTW 576

Query: 227  GLNKDGQLGLGHTEDVLYFTLCKSLLGCPIQQVACGWD--FTIILTKNGQVLSCGSNSFG 400
            G    G+LG G +ED     L   L G  +  VACG     T+ +T+NGQV S G   +G
Sbjct: 577  GRGNYGRLGHGSSEDEAIPMLVAGLKGLKVIDVACGSGDAQTLAVTENGQVWSWGDGDYG 636

Query: 401  QLGVPHGPRRCVVPQAIE-VQREKVVSIXXXXXXXXXXXXSGLVFQWGTGLASSGRRLCP 577
            +LG   G   C  P+ IE +Q   VV +             G V+ WG G     +RL  
Sbjct: 637  KLG-RGGSDGCKTPKLIEKLQDLDVVKVRCGSQFSVALTKDGQVYSWGKG---DNQRLGH 692

Query: 578  GQTLPLFLTAKEPSKVTGLENSQAVCVLAGSGHSASLTDAGELYVWGSNKHGQ 736
            G    +    + P  + GL+  + + V AGS H  +LT+  E++ WGSN   Q
Sbjct: 693  GTEEHV----RYPKLLEGLQGKKVIDVAAGSTHCLALTEDSEVHSWGSNDQCQ 741



 Score = 95.5 bits (236), Expect = 9e-20
 Identities = 92/343 (26%), Positives = 150/343 (43%), Gaps = 12/343 (3%)
 Frame = +2

Query: 56   LFAWGANSYGQLGLGHKEDVL-LPQQLSEFCKPGCVKRIT--GGGGHSAIVTDQGSLFVC 226
            ++A G  + G+LGLG     + +P+Q++       VK++    GG H+  +T  G +F  
Sbjct: 3014 VYACGEATNGRLGLGISSGTVPIPRQITALSSY-VVKKVAVHSGGRHATALTVDGKVFSW 3072

Query: 227  GLNKDGQLGLGHTEDVLYFTLCKSLLGCPIQQVACGWDFTIILTKNGQVLSCGSNSFGQL 406
            G   DG+LG     +     L ++L    I+ +ACG   +  LT +G++ + G   +G+L
Sbjct: 3073 GEGDDGKLGHFSRMNCDKPRLIEALKTKRIRDIACGSSHSAALTSSGELYTWGLGEYGRL 3132

Query: 407  GVPHGPRRCVV-PQAIEV---QREKVVSIXXXXXXXXXXXXSGLVFQWGTG-LASSGRRL 571
            G  HG     + P+ ++V    R   V+              GLVF WG G     GR  
Sbjct: 3133 G--HGDNTTQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFSWGDGDFGKLGRGG 3190

Query: 572  CPGQTLPLFLTAKEPSKVTGLENSQAVCVL-AGSGHSASLTDAGELYVWGSNKHGQLASQ 748
              G  +P  +            N Q VC +  G+  S +LT +G ++ WG   + +L   
Sbjct: 3191 SEGCNIPQNIERL---------NGQGVCQIECGAQFSLALTKSGVVWTWGKGDYFRLGHG 3241

Query: 749  A-AFLPLPQKIEAHRFQNEKVAAVWSGWTHLVAQTETGKVFTWGRADYGQLGRTLESPEG 925
            +   +  PQ +E  R   +K+  V  G  H +A T+ G+V+ WG  D+GQ G    +   
Sbjct: 3242 SDVHVRKPQVVEGLR--GKKIVHVAVGALHCLAVTDAGQVYAWGDNDHGQQGNGTTT--- 3296

Query: 926  WKPKKQASSLPCSRPARSVPSSLPCLTGA--TEVSCGSEHNLA 1048
                               P+ +  L G   T V+CGS H++A
Sbjct: 3297 ---------------VNRKPTLVQGLEGQKITRVACGSSHSVA 3324



 Score = 80.5 bits (197), Expect = 3e-15
 Identities = 84/331 (25%), Positives = 136/331 (41%), Gaps = 46/331 (13%)
 Frame = +2

Query: 338  DFTIILTKNGQVLSCGSNSFGQLGVPHGPRRCVVPQAIEVQREKVVSIXXXXXXXXXXXX 517
            D+T+    +G +   G N  GQLG   G +  V      +   + V +            
Sbjct: 3946 DWTLSAGGSGTIYGWGHNHRGQLGGIEGAKVKVPTPCEALAALRPVQLIGGEQTLFAVTA 4005

Query: 518  SGLVFQWGTGLASSGRRLCPGQTLPLFLTAKEPSKVTGLENSQ-----AVCVLAGSGHSA 682
             G ++  G G   +G RL  G T       +  S  T LE+ Q      V V +G  H  
Sbjct: 4006 DGKLYATGYG---AGGRLGVGGT-------ESVSTPTLLESIQHVFIKKVAVNSGGKHCL 4055

Query: 683  SLTDAGELYVWGSNKHGQLA-SQAAFLPLPQKIEAHRFQNEKVAAVWSGWTHLVAQTETG 859
            +L+  GE+Y WG  + G+L     +    P+ IE+ R    +V  V +G  H    T  G
Sbjct: 4056 ALSSEGEVYSWGEAEDGKLGHGNRSPCDRPRVIESLR--GTEVVDVAAGGAHSACVTAAG 4113

Query: 860  KVFTWGRADYGQLGRTLESPEGWKPK-------KQASSLPC-SRPARS------------ 979
             ++TWG+  YG+LG + +S +  KPK        +   + C S  A++            
Sbjct: 4114 DLYTWGKGRYGRLGHS-DSEDQLKPKLVEALQGHRVVDVACGSGDAQTLCLTDDDTVWSW 4172

Query: 980  -----------------VPSSLPCLT--GATEVSCGSEHNLAVV-GGTCYSWGWNEHGMC 1099
                             VP  +  LT  G  +V CGS+ ++A+   G  Y+WG  ++   
Sbjct: 4173 GDGDYGKLGRGGSDGCKVPMKIDSLTGLGVVKVECGSQFSVALTKSGAVYTWGKGDYHRL 4232

Query: 1100 GDGTEANVWTPKPVQALRSSSGLRLGCGAGH 1192
            G G++ +V  P+ VQ L+    + +  G+ H
Sbjct: 4233 GHGSDDHVRRPRQVQGLQGKKVIAIATGSLH 4263



 Score = 79.7 bits (195), Expect = 5e-15
 Identities = 80/337 (23%), Positives = 130/337 (38%), Gaps = 9/337 (2%)
 Frame = +2

Query: 101  HKEDVLLPQQLSEFCKPGCVKRITGGGGHSAI-VTDQGSLFVCGLNKDGQLGLGHT---- 265
            +  D L PQ +        VK      GH  + +   G ++  G    G+LG G T    
Sbjct: 478  YNSDTLAPQLVQGLASRNIVKIAAHSDGHHYLALAATGEVYSWGCGDGGRLGHGDTVPLE 537

Query: 266  EDVLYFTLCKSLLGCPIQQVACGWDFTIILTKNGQVLSCGSNSFGQLGVPHGPRRCVVPQ 445
            E  +         G  +  +ACG  ++  +T  G++ + G  ++G+LG        +   
Sbjct: 538  EPKVISAFSGKQAGKHVVHIACGSTYSAAITAEGELYTWGRGNYGRLGHGSSEDEAIPML 597

Query: 446  AIEVQREKVVSIXXXXXXXXXXXXS--GLVFQWGTG-LASSGRRLCPGQTLPLFLTAKEP 616
               ++  KV+ +            +  G V+ WG G     GR    G         K P
Sbjct: 598  VAGLKGLKVIDVACGSGDAQTLAVTENGQVWSWGDGDYGKLGRGGSDG--------CKTP 649

Query: 617  SKVTGLENSQAVCVLAGSGHSASLTDAGELYVWGSNKHGQLA-SQAAFLPLPQKIEAHRF 793
              +  L++   V V  GS  S +LT  G++Y WG   + +L       +  P+ +E    
Sbjct: 650  KLIEKLQDLDVVKVRCGSQFSVALTKDGQVYSWGKGDNQRLGHGTEEHVRYPKLLEG--L 707

Query: 794  QNEKVAAVWSGWTHLVAQTETGKVFTWGRADYGQLGRTLESPEGWKPKKQASSLPCSRPA 973
            Q +KV  V +G TH +A TE  +V +WG  D  Q   TL                  R  
Sbjct: 708  QGKKVIDVAAGSTHCLALTEDSEVHSWGSNDQCQHFDTL------------------RVT 749

Query: 974  RSVPSSLPCLTGATEVSCGSEHNLAVVGGTCYSWGWN 1084
            +  PS+LP L         ++H + +  G   S+ W+
Sbjct: 750  KPEPSALPGL--------DTKHIVGIACGPAQSFAWS 778



 Score = 73.2 bits (178), Expect = 5e-13
 Identities = 61/219 (27%), Positives = 95/219 (43%), Gaps = 3/219 (1%)
 Frame = +2

Query: 56   LFAWGANSYGQLGLGHKEDVLLPQQLSEFCKPGCVKRITGGGGHSAI-VTDQGSLFVCGL 232
            L+ WG  +YG+LG G  ED  +P  ++       +    G G    + VT+ G ++  G 
Sbjct: 573  LYTWGRGNYGRLGHGSSEDEAIPMLVAGLKGLKVIDVACGSGDAQTLAVTENGQVWSWGD 632

Query: 233  NKDGQLGLGHTEDVLYFTLCKSLLGCPIQQVACGWDFTIILTKNGQVLSCGSNSFGQLGV 412
               G+LG G ++      L + L    + +V CG  F++ LTK+GQV S G     +LG 
Sbjct: 633  GDYGKLGRGGSDGCKTPKLIEKLQDLDVVKVRCGSQFSVALTKDGQVYSWGKGDNQRLG- 691

Query: 413  PHGPRRCV-VPQAIE-VQREKVVSIXXXXXXXXXXXXSGLVFQWGTGLASSGRRLCPGQT 586
             HG    V  P+ +E +Q +KV+ +               V  WG     S  +     T
Sbjct: 692  -HGTEEHVRYPKLLEGLQGKKVIDVAAGSTHCLALTEDSEVHSWG-----SNDQCQHFDT 745

Query: 587  LPLFLTAKEPSKVTGLENSQAVCVLAGSGHSASLTDAGE 703
            L   +T  EPS + GL+    V +  G   S + +   E
Sbjct: 746  LR--VTKPEPSALPGLDTKHIVGIACGPAQSFAWSSCSE 782



 Score = 70.5 bits (171), Expect = 3e-12
 Identities = 59/204 (28%), Positives = 89/204 (43%), Gaps = 10/204 (4%)
 Frame = +2

Query: 614  PSKVTGLENSQAVCVLAGSG--HSASLTDAGELYVWGSNKHGQLA-SQAAFLPLPQKIEA 784
            P  V GL +   V + A S   H  +L   GE+Y WG    G+L       L  P+ I A
Sbjct: 485  PQLVQGLASRNIVKIAAHSDGHHYLALAATGEVYSWGCGDGGRLGHGDTVPLEEPKVISA 544

Query: 785  H--RFQNEKVAAVWSGWTHLVAQTETGKVFTWGRADYGQLGRTLESPEGWKPKKQASSLP 958
               +   + V  +  G T+  A T  G+++TWGR +YG+LG      E            
Sbjct: 545  FSGKQAGKHVVHIACGSTYSAAITAEGELYTWGRGNYGRLGHGSSEDE------------ 592

Query: 959  CSRPARSVPSSLPCLTG--ATEVSCGS--EHNLAVV-GGTCYSWGWNEHGMCGDGTEANV 1123
                  ++P  +  L G    +V+CGS     LAV   G  +SWG  ++G  G G     
Sbjct: 593  ------AIPMLVAGLKGLKVIDVACGSGDAQTLAVTENGQVWSWGDGDYGKLGRGGSDGC 646

Query: 1124 WTPKPVQALRSSSGLRLGCGAGHS 1195
             TPK ++ L+    +++ CG+  S
Sbjct: 647  KTPKLIEKLQDLDVVKVRCGSQFS 670



 Score = 50.1 bits (118), Expect = 4e-06
 Identities = 31/99 (31%), Positives = 49/99 (49%)
 Frame = +2

Query: 53   ALFAWGANSYGQLGLGHKEDVLLPQQLSEFCKPGCVKRITGGGGHSAIVTDQGSLFVCGL 232
            A++ WG   Y +LG G  + V  P+Q+ +  +   V  I  G  H    ++ G ++  G 
Sbjct: 4220 AVYTWGKGDYHRLGHGSDDHVRRPRQV-QGLQGKKVIAIATGSLHCVCCSEDGEVYTWGD 4278

Query: 233  NKDGQLGLGHTEDVLYFTLCKSLLGCPIQQVACGWDFTI 349
            N +GQLG G T  +    L  +L G  + +VACG   T+
Sbjct: 4279 NDEGQLGDGTTNAIQRPRLVAALQGKKVNRVACGSAHTL 4317


>ref|XP_002685237.1| PREDICTED: hect domain and RLD 3-like [Bos taurus].
          Length = 4837

 Score =  125 bits (315), Expect = 6e-29
 Identities = 117/390 (30%), Positives = 171/390 (43%), Gaps = 10/390 (2%)
 Frame = +2

Query: 56   LFAWGANSYGQLG--LGHKEDVLLPQQLSEFCKPGCVKRITGGGGHSAIVTDQGSLFVCG 229
            ++ WG N  GQLG   G K  V  P +     +P    ++ GG      VT  G L+  G
Sbjct: 3957 IYGWGHNHRGQLGGIEGAKVKVPTPCEALAALRP---VQLIGGEQTLFAVTADGKLYATG 4013

Query: 230  LNKDGQLGLGHTEDVLYFTLCKSLLGCPIQQVAC--GWDFTIILTKNGQVLSCGSNSFGQ 403
                G+LG+G TE V   TL +S+    I++VA   G    + L+  G+V S G    G+
Sbjct: 4014 YGAGGRLGVGGTESVSTPTLLESIQHVFIKKVAVNSGGKHCLALSSEGEVYSWGEAEDGK 4073

Query: 404  LGVPHGPRR-CVVPQAIEVQR-EKVVSIXXXXXXXXXXXXSGLVFQWGTG-LASSGRRLC 574
            LG  HG R  C  P+ IE  R  +VV +            +G ++ WG G     G    
Sbjct: 4074 LG--HGNRSPCDRPRVIESLRGTEVVDVAAGGAHSACVTAAGDLYTWGKGRYGRLGHSDS 4131

Query: 575  PGQTLPLFLTAKEPSKVTGLENSQAVCVLAGSGHSASL--TDAGELYVWGSNKHGQLASQ 748
              Q         +P  V  L+  + V V  GSG + +L  TD   ++ WG   +G+L   
Sbjct: 4132 EDQL--------KPKLVEALQGHRVVDVACGSGDAQTLCLTDDDTVWSWGDGDYGKLGRG 4183

Query: 749  AAF-LPLPQKIEAHRFQNEKVAAVWSGWTHLVAQTETGKVFTWGRADYGQLGRTLESPEG 925
             +    +P KI++       V  V  G    VA T++G V+TWG+ DY +LG    S + 
Sbjct: 4184 GSDGCKVPMKIDS--LTGLGVVKVECGSQFSVALTKSGAVYTWGKGDYHRLGHG--SDDH 4239

Query: 926  WKPKKQASSLPCSRPARSVPSSLPCLTGATEVSCGSEHNLAVVGGTCYSWGWNEHGMCGD 1105
             +  +Q   L   +       SL C+       C SE       G  Y+WG N+ G  GD
Sbjct: 4240 VRRPRQVQGLQGKKVIAIATGSLHCV-------CCSED------GEVYTWGDNDEGQLGD 4286

Query: 1106 GTEANVWTPKPVQALRSSSGLRLGCGAGHS 1195
            GT   +  P+ V AL+     R+ CG+ H+
Sbjct: 4287 GTTNAIQRPRLVAALQGKKVNRVACGSAHT 4316



 Score =  119 bits (298), Expect = 6e-27
 Identities = 117/398 (29%), Positives = 167/398 (41%), Gaps = 16/398 (4%)
 Frame = +2

Query: 50   TALFAWGANSYGQLGLGHKEDVLLPQQLSEFCKPGCVKRITGGGGHSAIVTDQGSLFVCG 229
            T +F WG N   QLG G K   +     SE      V ++ GG      VT +G ++ CG
Sbjct: 2960 TKVFVWGLNDKDQLG-GLKGSKIKVPSFSETLSALNVVQVAGGSKSLFAVTVEGKVYACG 3018

Query: 230  LNKDGQLGLGHTEDVLYFTL-CKSLLGCPIQQVAC--GWDFTIILTKNGQVLSCGSNSFG 400
               +G+LGLG +   +       +L    +++VA   G      LT +G+V S G    G
Sbjct: 3019 EATNGRLGLGISSGTVPIPRQITALSSYVVKKVAVHSGGRHATALTVDGKVFSWGEGDDG 3078

Query: 401  QLGVPHGPR-RCVVPQAIEVQREKVV-SIXXXXXXXXXXXXSGLVFQWGTGLASSGRRLC 574
            +LG  H  R  C  P+ IE  + K +  I            SG ++ WG G      RL 
Sbjct: 3079 KLG--HFSRMNCDKPRLIEALKTKRIRDIACGSSHSAALTSSGELYTWGLGEYG---RLG 3133

Query: 575  PGQTLPLFLTAKEPSKVTGLENSQAVCVLAGS--GHSASLTDAGELYVWGSNKHGQLASQ 748
             G       T  +P  V  L   + + V  GS    + +LTD G ++ WG    G+L   
Sbjct: 3134 HGDNT----TQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFSWGDGDFGKLGRG 3189

Query: 749  AAF-LPLPQKIEAHRFQNEKVAAVWSGWTHLVAQTETGKVFTWGRADYGQLG-------R 904
             +    +PQ IE  R   + V  +  G    +A T++G V+TWG+ DY +LG       R
Sbjct: 3190 GSEGCNIPQNIE--RLNGQGVCQIECGAQFSLALTKSGVVWTWGKGDYFRLGHGSDVHVR 3247

Query: 905  TLESPEGWKPKKQASSLPCSRPARSVPSSLPCLTGATEVSCGSEHNLAVV-GGTCYSWGW 1081
              +  EG + KK                          V+ G+ H LAV   G  Y+WG 
Sbjct: 3248 KPQVVEGLRGKK-----------------------IVHVAVGALHCLAVTDAGQVYAWGD 3284

Query: 1082 NEHGMCGDGTEANVWTPKPVQALRSSSGLRLGCGAGHS 1195
            N+HG  G+GT      P  VQ L      R+ CG+ HS
Sbjct: 3285 NDHGQQGNGTTTVNRKPTLVQGLEGQKITRVACGSSHS 3322



 Score =  114 bits (284), Expect = 2e-25
 Identities = 88/268 (32%), Positives = 126/268 (47%), Gaps = 3/268 (1%)
 Frame = +2

Query: 56   LFAWGANSYGQLGLGHKEDVLLPQQLSEFCKPGCVKRITGGGGHSAIVTDQGSLFVCGLN 235
            +F+WG    G+LG   + +   P+ L E  K   ++ I  G  HSA +T  G L+  GL 
Sbjct: 3069 VFSWGEGDDGKLGHFSRMNCDKPR-LIEALKTKRIRDIACGSSHSAALTSSGELYTWGLG 3127

Query: 236  KDGQLGLGHTEDVLYFTLCKSLLGCPIQQVACGWDF--TIILTKNGQVLSCGSNSFGQLG 409
            + G+LG G     L   + K LLG  + QVACG     T+ LT  G V S G   FG+LG
Sbjct: 3128 EYGRLGHGDNTTQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFSWGDGDFGKLG 3187

Query: 410  VPHGPRRCVVPQAIE-VQREKVVSIXXXXXXXXXXXXSGLVFQWGTGLASSGRRLCPGQT 586
               G   C +PQ IE +  + V  I            SG+V+ WG G      RL  G  
Sbjct: 3188 -RGGSEGCNIPQNIERLNGQGVCQIECGAQFSLALTKSGVVWTWGKG---DYFRLGHGSD 3243

Query: 587  LPLFLTAKEPSKVTGLENSQAVCVLAGSGHSASLTDAGELYVWGSNKHGQLASQAAFLPL 766
            + +    ++P  V GL   + V V  G+ H  ++TDAG++Y WG N HGQ  +    +  
Sbjct: 3244 VHV----RKPQVVEGLRGKKIVHVAVGALHCLAVTDAGQVYAWGDNDHGQQGNGTTTVNR 3299

Query: 767  PQKIEAHRFQNEKVAAVWSGWTHLVAQT 850
               +     + +K+  V  G +H VA T
Sbjct: 3300 KPTL-VQGLEGQKITRVACGSSHSVAWT 3326



 Score =  110 bits (274), Expect = 3e-24
 Identities = 91/348 (26%), Positives = 148/348 (42%), Gaps = 11/348 (3%)
 Frame = +2

Query: 182  GHSAIVTDQGSLFVCGLNKDGQLGLGHTEDVLYFTLCKSLLGCPIQQVACGWDFTIILTK 361
            G  +  T +  +FV GLN   QLG      +   +  ++L    + QVA G      +T 
Sbjct: 2951 GLESAATIRTKVFVWGLNDKDQLGGLKGSKIKVPSFSETLSALNVVQVAGGSKSLFAVTV 3010

Query: 362  NGQVLSCGSNSFGQLGVPHGPRRCVVPQAIEVQRE---KVVSIXXXXXXXXXXXXSGLVF 532
             G+V +CG  + G+LG+        +P+ I        K V++             G VF
Sbjct: 3011 EGKVYACGEATNGRLGLGISSGTVPIPRQITALSSYVVKKVAVHSGGRHATALTVDGKVF 3070

Query: 533  QWGTG----LASSGRRLCPGQTLPLFLTAKEPSKVTGLENSQAVCVLAGSGHSASLTDAG 700
             WG G    L    R  C            +P  +  L+  +   +  GS HSA+LT +G
Sbjct: 3071 SWGEGDDGKLGHFSRMNC-----------DKPRLIEALKTKRIRDIACGSSHSAALTSSG 3119

Query: 701  ELYVWGSNKHGQLASQAAFLPL-PQKIEAHRFQNEKVAAVWSGWTHLVAQTETGKVFTWG 877
            ELY WG  ++G+L        L P+ ++          A  S     +A T+ G VF+WG
Sbjct: 3120 ELYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFSWG 3179

Query: 878  RADYGQLGRTLESPEGWKPKKQASSLPCSRPARSVPSSLPCLT--GATEVSCGSEHNLAV 1051
              D+G+LGR               S  C     ++P ++  L   G  ++ CG++ +LA+
Sbjct: 3180 DGDFGKLGR-------------GGSEGC-----NIPQNIERLNGQGVCQIECGAQFSLAL 3221

Query: 1052 V-GGTCYSWGWNEHGMCGDGTEANVWTPKPVQALRSSSGLRLGCGAGH 1192
               G  ++WG  ++   G G++ +V  P+ V+ LR    + +  GA H
Sbjct: 3222 TKSGVVWTWGKGDYFRLGHGSDVHVRKPQVVEGLRGKKIVHVAVGALH 3269



 Score =  108 bits (269), Expect = 1e-23
 Identities = 90/326 (27%), Positives = 143/326 (43%), Gaps = 9/326 (2%)
 Frame = +2

Query: 242  GQLGLGHTEDVLYFTLCKSLLGCPIQQVACGWDFTIILTKNGQVLSCGSNSFGQLGVPHG 421
            G +G  +  +V+    C+ L    + Q+AC     +IL++NG+V +   NS         
Sbjct: 430  GLIGWKYYANVIGPIQCEGLANLGVTQIACAEKRFLILSRNGRVYTQAYNS--------- 480

Query: 422  PRRCVVPQAIE-VQREKVVSIXXXXXXXXXXXXS--GLVFQWGTGLASSGRRLCPGQTLP 592
                + PQ ++ +    +V I            +  G V+ WG G    G RL  G T+P
Sbjct: 481  --DTLAPQLVQGLASRNIVKIAAHSDGHHYLALAATGEVYSWGCG---DGGRLGHGDTVP 535

Query: 593  LFLTAKEPSKVTGLENSQA----VCVLAGSGHSASLTDAGELYVWGSNKHGQLA-SQAAF 757
            L    +EP  ++     QA    V +  GS +SA++T  GELY WG   +G+L    +  
Sbjct: 536  L----EEPKVISAFSGKQAGKHVVHIACGSTYSAAITAEGELYTWGRGNYGRLGHGSSED 591

Query: 758  LPLPQKIEAHRFQNEKVAAVWSGWTHLVAQTETGKVFTWGRADYGQLGRTLESPEGWKPK 937
              +P  +   +       A  SG    +A TE G+V++WG  DYG+LGR     +G K  
Sbjct: 592  EAIPMLVAGLKGLKVIDVACGSGDAQTLAVTENGQVWSWGDGDYGKLGR--GGSDGCKTP 649

Query: 938  KQASSLPCSRPARSVPSSLPCLTGATEVSCGSEHNLAVV-GGTCYSWGWNEHGMCGDGTE 1114
            K    L                    +V CGS+ ++A+   G  YSWG  ++   G GTE
Sbjct: 650  KLIEKLQD--------------LDVVKVRCGSQFSVALTKDGQVYSWGKGDNQRLGHGTE 695

Query: 1115 ANVWTPKPVQALRSSSGLRLGCGAGH 1192
             +V  PK ++ L+    + +  G+ H
Sbjct: 696  EHVRYPKLLEGLQGKKVIDVAAGSTH 721



 Score =  101 bits (252), Expect = 1e-21
 Identities = 82/267 (30%), Positives = 122/267 (45%), Gaps = 4/267 (1%)
 Frame = +2

Query: 56   LFAWGANSYGQLGLGHKEDVLLPQQLSEFCKPGCVKRITGGGGHSAIVTDQGSLFVCGLN 235
            +++WG    G+LG G++     P+ + E  +   V  +  GG HSA VT  G L+  G  
Sbjct: 4063 VYSWGEAEDGKLGHGNRSPCDRPRVI-ESLRGTEVVDVAAGGAHSACVTAAGDLYTWGKG 4121

Query: 236  KDGQLGLGHTEDVLYFTLCKSLLGCPIQQVACGWD--FTIILTKNGQVLSCGSNSFGQLG 409
            + G+LG   +ED L   L ++L G  +  VACG     T+ LT +  V S G   +G+LG
Sbjct: 4122 RYGRLGHSDSEDQLKPKLVEALQGHRVVDVACGSGDAQTLCLTDDDTVWSWGDGDYGKLG 4181

Query: 410  VPHGPRRCVVPQAIE-VQREKVVSIXXXXXXXXXXXXSGLVFQWGTGLASSGRRLCPGQT 586
               G   C VP  I+ +    VV +            SG V+ WG G      RL  G  
Sbjct: 4182 -RGGSDGCKVPMKIDSLTGLGVVKVECGSQFSVALTKSGAVYTWGKG---DYHRLGHGSD 4237

Query: 587  LPLFLTAKEPSKVTGLENSQAVCVLAGSGHSASLTDAGELYVWGSNKHGQLASQAA-FLP 763
              +    + P +V GL+  + + +  GS H    ++ GE+Y WG N  GQL       + 
Sbjct: 4238 DHV----RRPRQVQGLQGKKVIAIATGSLHCVCCSEDGEVYTWGDNDEGQLGDGTTNAIQ 4293

Query: 764  LPQKIEAHRFQNEKVAAVWSGWTHLVA 844
             P+ + A   Q +KV  V  G  H +A
Sbjct: 4294 RPRLVAA--LQGKKVNRVACGSAHTLA 4318



 Score = 97.8 bits (242), Expect = 2e-20
 Identities = 73/233 (31%), Positives = 108/233 (46%), Gaps = 6/233 (2%)
 Frame = +2

Query: 56   LFAWGANSYGQLGLGHKEDVLLPQQLSEFCKPGCVKRITG---GGGHSAIVTDQGSLFVC 226
            +++WG    G+LG G    +  P+ +S F      K +     G  +SA +T +G L+  
Sbjct: 517  VYSWGCGDGGRLGHGDTVPLEEPKVISAFSGKQAGKHVVHIACGSTYSAAITAEGELYTW 576

Query: 227  GLNKDGQLGLGHTEDVLYFTLCKSLLGCPIQQVACGWD--FTIILTKNGQVLSCGSNSFG 400
            G    G+LG G +ED     L   L G  +  VACG     T+ +T+NGQV S G   +G
Sbjct: 577  GRGNYGRLGHGSSEDEAIPMLVAGLKGLKVIDVACGSGDAQTLAVTENGQVWSWGDGDYG 636

Query: 401  QLGVPHGPRRCVVPQAIE-VQREKVVSIXXXXXXXXXXXXSGLVFQWGTGLASSGRRLCP 577
            +LG   G   C  P+ IE +Q   VV +             G V+ WG G     +RL  
Sbjct: 637  KLG-RGGSDGCKTPKLIEKLQDLDVVKVRCGSQFSVALTKDGQVYSWGKG---DNQRLGH 692

Query: 578  GQTLPLFLTAKEPSKVTGLENSQAVCVLAGSGHSASLTDAGELYVWGSNKHGQ 736
            G    +    + P  + GL+  + + V AGS H  +LT+  E++ WGSN   Q
Sbjct: 693  GTEEHV----RYPKLLEGLQGKKVIDVAAGSTHCLALTEDSEVHSWGSNDQCQ 741



 Score = 95.5 bits (236), Expect = 9e-20
 Identities = 92/343 (26%), Positives = 150/343 (43%), Gaps = 12/343 (3%)
 Frame = +2

Query: 56   LFAWGANSYGQLGLGHKEDVL-LPQQLSEFCKPGCVKRIT--GGGGHSAIVTDQGSLFVC 226
            ++A G  + G+LGLG     + +P+Q++       VK++    GG H+  +T  G +F  
Sbjct: 3014 VYACGEATNGRLGLGISSGTVPIPRQITALSSY-VVKKVAVHSGGRHATALTVDGKVFSW 3072

Query: 227  GLNKDGQLGLGHTEDVLYFTLCKSLLGCPIQQVACGWDFTIILTKNGQVLSCGSNSFGQL 406
            G   DG+LG     +     L ++L    I+ +ACG   +  LT +G++ + G   +G+L
Sbjct: 3073 GEGDDGKLGHFSRMNCDKPRLIEALKTKRIRDIACGSSHSAALTSSGELYTWGLGEYGRL 3132

Query: 407  GVPHGPRRCVV-PQAIEV---QREKVVSIXXXXXXXXXXXXSGLVFQWGTG-LASSGRRL 571
            G  HG     + P+ ++V    R   V+              GLVF WG G     GR  
Sbjct: 3133 G--HGDNTTQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFSWGDGDFGKLGRGG 3190

Query: 572  CPGQTLPLFLTAKEPSKVTGLENSQAVCVL-AGSGHSASLTDAGELYVWGSNKHGQLASQ 748
              G  +P  +            N Q VC +  G+  S +LT +G ++ WG   + +L   
Sbjct: 3191 SEGCNIPQNIERL---------NGQGVCQIECGAQFSLALTKSGVVWTWGKGDYFRLGHG 3241

Query: 749  A-AFLPLPQKIEAHRFQNEKVAAVWSGWTHLVAQTETGKVFTWGRADYGQLGRTLESPEG 925
            +   +  PQ +E  R   +K+  V  G  H +A T+ G+V+ WG  D+GQ G    +   
Sbjct: 3242 SDVHVRKPQVVEGLR--GKKIVHVAVGALHCLAVTDAGQVYAWGDNDHGQQGNGTTT--- 3296

Query: 926  WKPKKQASSLPCSRPARSVPSSLPCLTGA--TEVSCGSEHNLA 1048
                               P+ +  L G   T V+CGS H++A
Sbjct: 3297 ---------------VNRKPTLVQGLEGQKITRVACGSSHSVA 3324



 Score = 80.5 bits (197), Expect = 3e-15
 Identities = 84/331 (25%), Positives = 136/331 (41%), Gaps = 46/331 (13%)
 Frame = +2

Query: 338  DFTIILTKNGQVLSCGSNSFGQLGVPHGPRRCVVPQAIEVQREKVVSIXXXXXXXXXXXX 517
            D+T+    +G +   G N  GQLG   G +  V      +   + V +            
Sbjct: 3946 DWTLSAGGSGTIYGWGHNHRGQLGGIEGAKVKVPTPCEALAALRPVQLIGGEQTLFAVTA 4005

Query: 518  SGLVFQWGTGLASSGRRLCPGQTLPLFLTAKEPSKVTGLENSQ-----AVCVLAGSGHSA 682
             G ++  G G   +G RL  G T       +  S  T LE+ Q      V V +G  H  
Sbjct: 4006 DGKLYATGYG---AGGRLGVGGT-------ESVSTPTLLESIQHVFIKKVAVNSGGKHCL 4055

Query: 683  SLTDAGELYVWGSNKHGQLA-SQAAFLPLPQKIEAHRFQNEKVAAVWSGWTHLVAQTETG 859
            +L+  GE+Y WG  + G+L     +    P+ IE+ R    +V  V +G  H    T  G
Sbjct: 4056 ALSSEGEVYSWGEAEDGKLGHGNRSPCDRPRVIESLR--GTEVVDVAAGGAHSACVTAAG 4113

Query: 860  KVFTWGRADYGQLGRTLESPEGWKPK-------KQASSLPC-SRPARS------------ 979
             ++TWG+  YG+LG + +S +  KPK        +   + C S  A++            
Sbjct: 4114 DLYTWGKGRYGRLGHS-DSEDQLKPKLVEALQGHRVVDVACGSGDAQTLCLTDDDTVWSW 4172

Query: 980  -----------------VPSSLPCLT--GATEVSCGSEHNLAVV-GGTCYSWGWNEHGMC 1099
                             VP  +  LT  G  +V CGS+ ++A+   G  Y+WG  ++   
Sbjct: 4173 GDGDYGKLGRGGSDGCKVPMKIDSLTGLGVVKVECGSQFSVALTKSGAVYTWGKGDYHRL 4232

Query: 1100 GDGTEANVWTPKPVQALRSSSGLRLGCGAGH 1192
            G G++ +V  P+ VQ L+    + +  G+ H
Sbjct: 4233 GHGSDDHVRRPRQVQGLQGKKVIAIATGSLH 4263



 Score = 79.7 bits (195), Expect = 5e-15
 Identities = 80/337 (23%), Positives = 130/337 (38%), Gaps = 9/337 (2%)
 Frame = +2

Query: 101  HKEDVLLPQQLSEFCKPGCVKRITGGGGHSAI-VTDQGSLFVCGLNKDGQLGLGHT---- 265
            +  D L PQ +        VK      GH  + +   G ++  G    G+LG G T    
Sbjct: 478  YNSDTLAPQLVQGLASRNIVKIAAHSDGHHYLALAATGEVYSWGCGDGGRLGHGDTVPLE 537

Query: 266  EDVLYFTLCKSLLGCPIQQVACGWDFTIILTKNGQVLSCGSNSFGQLGVPHGPRRCVVPQ 445
            E  +         G  +  +ACG  ++  +T  G++ + G  ++G+LG        +   
Sbjct: 538  EPKVISAFSGKQAGKHVVHIACGSTYSAAITAEGELYTWGRGNYGRLGHGSSEDEAIPML 597

Query: 446  AIEVQREKVVSIXXXXXXXXXXXXS--GLVFQWGTG-LASSGRRLCPGQTLPLFLTAKEP 616
               ++  KV+ +            +  G V+ WG G     GR    G         K P
Sbjct: 598  VAGLKGLKVIDVACGSGDAQTLAVTENGQVWSWGDGDYGKLGRGGSDG--------CKTP 649

Query: 617  SKVTGLENSQAVCVLAGSGHSASLTDAGELYVWGSNKHGQLA-SQAAFLPLPQKIEAHRF 793
              +  L++   V V  GS  S +LT  G++Y WG   + +L       +  P+ +E    
Sbjct: 650  KLIEKLQDLDVVKVRCGSQFSVALTKDGQVYSWGKGDNQRLGHGTEEHVRYPKLLEG--L 707

Query: 794  QNEKVAAVWSGWTHLVAQTETGKVFTWGRADYGQLGRTLESPEGWKPKKQASSLPCSRPA 973
            Q +KV  V +G TH +A TE  +V +WG  D  Q   TL                  R  
Sbjct: 708  QGKKVIDVAAGSTHCLALTEDSEVHSWGSNDQCQHFDTL------------------RVT 749

Query: 974  RSVPSSLPCLTGATEVSCGSEHNLAVVGGTCYSWGWN 1084
            +  PS+LP L         ++H + +  G   S+ W+
Sbjct: 750  KPEPSALPGL--------DTKHIVGIACGPAQSFAWS 778



 Score = 73.2 bits (178), Expect = 5e-13
 Identities = 61/219 (27%), Positives = 95/219 (43%), Gaps = 3/219 (1%)
 Frame = +2

Query: 56   LFAWGANSYGQLGLGHKEDVLLPQQLSEFCKPGCVKRITGGGGHSAI-VTDQGSLFVCGL 232
            L+ WG  +YG+LG G  ED  +P  ++       +    G G    + VT+ G ++  G 
Sbjct: 573  LYTWGRGNYGRLGHGSSEDEAIPMLVAGLKGLKVIDVACGSGDAQTLAVTENGQVWSWGD 632

Query: 233  NKDGQLGLGHTEDVLYFTLCKSLLGCPIQQVACGWDFTIILTKNGQVLSCGSNSFGQLGV 412
               G+LG G ++      L + L    + +V CG  F++ LTK+GQV S G     +LG 
Sbjct: 633  GDYGKLGRGGSDGCKTPKLIEKLQDLDVVKVRCGSQFSVALTKDGQVYSWGKGDNQRLG- 691

Query: 413  PHGPRRCV-VPQAIE-VQREKVVSIXXXXXXXXXXXXSGLVFQWGTGLASSGRRLCPGQT 586
             HG    V  P+ +E +Q +KV+ +               V  WG     S  +     T
Sbjct: 692  -HGTEEHVRYPKLLEGLQGKKVIDVAAGSTHCLALTEDSEVHSWG-----SNDQCQHFDT 745

Query: 587  LPLFLTAKEPSKVTGLENSQAVCVLAGSGHSASLTDAGE 703
            L   +T  EPS + GL+    V +  G   S + +   E
Sbjct: 746  LR--VTKPEPSALPGLDTKHIVGIACGPAQSFAWSSCSE 782



 Score = 70.5 bits (171), Expect = 3e-12
 Identities = 59/204 (28%), Positives = 89/204 (43%), Gaps = 10/204 (4%)
 Frame = +2

Query: 614  PSKVTGLENSQAVCVLAGSG--HSASLTDAGELYVWGSNKHGQLA-SQAAFLPLPQKIEA 784
            P  V GL +   V + A S   H  +L   GE+Y WG    G+L       L  P+ I A
Sbjct: 485  PQLVQGLASRNIVKIAAHSDGHHYLALAATGEVYSWGCGDGGRLGHGDTVPLEEPKVISA 544

Query: 785  H--RFQNEKVAAVWSGWTHLVAQTETGKVFTWGRADYGQLGRTLESPEGWKPKKQASSLP 958
               +   + V  +  G T+  A T  G+++TWGR +YG+LG      E            
Sbjct: 545  FSGKQAGKHVVHIACGSTYSAAITAEGELYTWGRGNYGRLGHGSSEDE------------ 592

Query: 959  CSRPARSVPSSLPCLTG--ATEVSCGS--EHNLAVV-GGTCYSWGWNEHGMCGDGTEANV 1123
                  ++P  +  L G    +V+CGS     LAV   G  +SWG  ++G  G G     
Sbjct: 593  ------AIPMLVAGLKGLKVIDVACGSGDAQTLAVTENGQVWSWGDGDYGKLGRGGSDGC 646

Query: 1124 WTPKPVQALRSSSGLRLGCGAGHS 1195
             TPK ++ L+    +++ CG+  S
Sbjct: 647  KTPKLIEKLQDLDVVKVRCGSQFS 670



 Score = 50.1 bits (118), Expect = 4e-06
 Identities = 31/99 (31%), Positives = 49/99 (49%)
 Frame = +2

Query: 53   ALFAWGANSYGQLGLGHKEDVLLPQQLSEFCKPGCVKRITGGGGHSAIVTDQGSLFVCGL 232
            A++ WG   Y +LG G  + V  P+Q+ +  +   V  I  G  H    ++ G ++  G 
Sbjct: 4220 AVYTWGKGDYHRLGHGSDDHVRRPRQV-QGLQGKKVIAIATGSLHCVCCSEDGEVYTWGD 4278

Query: 233  NKDGQLGLGHTEDVLYFTLCKSLLGCPIQQVACGWDFTI 349
            N +GQLG G T  +    L  +L G  + +VACG   T+
Sbjct: 4279 NDEGQLGDGTTNAIQRPRLVAALQGKKVNRVACGSAHTL 4317


>ref|NP_001070362.2| hect domain and RLD 4 [Bos taurus].
          Length = 1057

 Score =  122 bits (307), Expect = 5e-28
 Identities = 110/372 (29%), Positives = 168/372 (45%), Gaps = 9/372 (2%)
 Frame = +2

Query: 56   LFAWGANSYGQLGLGH-KEDVLLPQQLSEFCKPGCVKRITGGGGHSAIVTDQGSLFVCGL 232
            +  WG  S+GQLGLG   E+++L  + S+F     V+ +  G  H+  V D G+++ CG 
Sbjct: 1    MLCWGNASFGQLGLGGIDEEIVLEPRKSDFFINKKVRDVGCGLRHTVFVLDDGTVYTCGC 60

Query: 233  NKDGQLGLGHTEDVLYFTLCKSLLGCPIQQVACGWDFTIILTKNGQVLSCGSNSFGQLGV 412
            N  GQ  LGH +         +L    I  V+CG   T+ L   GQV + G +S GQLG+
Sbjct: 61   NDLGQ--LGHEKSRKKPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGL 118

Query: 413  PHGPRRCV-VPQAIEVQRE-KVVSIXXXXXXXXXXXXSGLVFQWGTGLASSGRRLCPGQT 586
              G   C+ VP+ I+   + ++V +            +  VF WG               
Sbjct: 119  -LGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQ--------- 168

Query: 587  LPLFLTAKE---PSKVTGLENSQAVCVLAGSGHSASLTDAGELYVWGSNKHGQLA-SQAA 754
            L L +  K+   P  +  L     + + AG  HS  LT +G ++ WG NK GQL  +   
Sbjct: 169  LGLGIDCKKQASPQLIKSLLGIPFMQIAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDEN 228

Query: 755  FLPLPQKIEAHRFQNEKVAAVWSGWTHLVAQTETGKVFTWGRADYGQLGRTLESPEGWKP 934
               +P  +++ R Q  K+  +  G  H  A T+ G VFT+G   YGQLG    S E   P
Sbjct: 229  DRYVPNLLKSLRTQ--KIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHE-INP 285

Query: 935  KKQASSLPCSRPARSVPSSLPCLTGATEVSCGSEHNLAVV--GGTCYSWGWNEHGMCGDG 1108
            +K    +                +  T+++CG +H  A V   G  YS+G   +G  G G
Sbjct: 286  RKVFELMG---------------SIVTQIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTG 330

Query: 1109 TEANVWTPKPVQ 1144
            + +N  +P  V+
Sbjct: 331  STSNRKSPFTVK 342



 Score = 87.4 bits (215), Expect = 2e-17
 Identities = 55/201 (27%), Positives = 97/201 (48%), Gaps = 5/201 (2%)
 Frame = +2

Query: 608  KEPSKVTGLENSQAVCVLAGSGHSASLTDAGELYVWGSNKHGQLA--SQAAFLPLPQKIE 781
            K+P +V  L+    V V  G  H+ +L D G++Y WG +  GQL        + +P+ I+
Sbjct: 73   KKPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGLLGSEECIRVPRNIK 132

Query: 782  AHRFQNEKVAAVWSGWTHLVAQTETGKVFTWGRADYGQLGRTLESPEGWKPKKQASSLPC 961
            +    + ++  V  G+ H +A ++  +VF WG+  YGQLG  ++       KKQAS    
Sbjct: 133  S--LSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGIDC------KKQAS---- 180

Query: 962  SRPARSVPSSLPCLTGA--TEVSCGSEHNLAV-VGGTCYSWGWNEHGMCGDGTEANVWTP 1132
                   P  +  L G    +++ G  H+  + + G  + WG N+ G  G   E + + P
Sbjct: 181  -------PQLIKSLLGIPFMQIAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVP 233

Query: 1133 KPVQALRSSSGLRLGCGAGHS 1195
              +++LR+   + + CG  H+
Sbjct: 234  NLLKSLRTQKIVYICCGEDHT 254



 Score = 65.1 bits (157), Expect = 1e-10
 Identities = 40/120 (33%), Positives = 58/120 (48%), Gaps = 1/120 (0%)
 Frame = +2

Query: 53  ALFAWGANSYGQLGLGHKEDVLLPQQLSEFCKPGCVKRITGGGGHSAIVTDQGSLFVCGL 232
           A+F WG N +GQLGL  + D  +P  L    +   +  I  G  H+A +T +G +F  G 
Sbjct: 210 AIFGWGRNKFGQLGLNDENDRYVPNLLKSL-RTQKIVYICCGEDHTAALTKEGGVFTFGA 268

Query: 233 NKDGQLGLGHTEDVLYFTLCKSLLGCPIQQVACGWDFT-IILTKNGQVLSCGSNSFGQLG 409
              GQLG   T   +       L+G  + Q+ACG   T   +  +G++ S G    GQLG
Sbjct: 269 GGYGQLGHNSTSHEINPRKVFELMGSIVTQIACGRQHTSAFVPSSGRIYSFGLGGNGQLG 328


>ref|NP_001179920.1| RCC1 and BTB domain-containing protein 2 [Bos taurus].
          Length = 527

 Score =  107 bits (268), Expect = 2e-23
 Identities = 83/287 (28%), Positives = 131/287 (45%), Gaps = 12/287 (4%)
 Frame = +2

Query: 56  LFAWGANSYGQLGLGHKEDVLLPQQLSEFCKPGCVKRITGGGGHSAIVTDQGSLFVCGLN 235
           +F  G N  G LGLG  +  + P++L             G G H  + T +G +F  G N
Sbjct: 43  IFVLGTNCCGCLGLGDVQSTIEPRRLDSLSGKKIACLSYGSGPHIVLATTEGEVFTWGHN 102

Query: 236 KDGQLGLGHTE-DVLYFTLCKSLLGCPIQQVACGWDFTIILTKNGQVLSCGSNSFGQLGV 412
              QLG G T   ++ + +  +L    + +VACG   +++LT +G+V + G N+ GQ+G 
Sbjct: 103 AYSQLGNGTTNAGLVPYHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGS 162

Query: 413 PHGPRRCVVPQAIE--VQREKVVSIXXXXXXXXXXXXSGLVFQWG------TGLASSGRR 568
                +  +P+ +   +Q + VV+I            +G VF WG       GL SSG +
Sbjct: 163 GSTANQ-PIPRRVTGCLQSKVVVNIACGQMCSMAVVNTGEVFVWGYNGNGQLGLGSSGNQ 221

Query: 569 LCPGQTLPLFLTAKEPSKVTGLENSQAVCVLAGSGHSASLTDAGELYVWGSNKHGQLAS- 745
                          P +V  L+  +   V  G  H+  LTD G++Y WG+N +GQL + 
Sbjct: 222 -------------PTPCRVAALQGIRVQRVACGYAHTLVLTDEGQVYAWGANSYGQLGTG 268

Query: 746 --QAAFLPLPQKIEAHRFQNEKVAAVWSGWTHLVAQTETGKVFTWGR 880
                  P P  +E  R    ++AA  S  T   A+T+ G V+ WG+
Sbjct: 269 NKSNQSYPTPVVVEKDRI--IEIAACHSAHTS-AAKTQGGHVYMWGQ 312



 Score = 87.8 bits (216), Expect = 2e-17
 Identities = 76/254 (29%), Positives = 117/254 (46%), Gaps = 11/254 (4%)
 Frame = +2

Query: 200 TDQGSLFVCGLNKDGQLGLGHTEDVLYFTLCKSLLGCPIQQVACGWDFTIIL-TKNGQVL 376
           T    +FV G N  G LGLG  +  +      SL G  I  ++ G    I+L T  G+V 
Sbjct: 38  TVNDEIFVLGTNCCGCLGLGDVQSTIEPRRLDSLSGKKIACLSYGSGPHIVLATTEGEVF 97

Query: 377 SCGSNSFGQLGVPHGPRRC-VVPQAIE--VQREKVVSIXXXXXXXXXXXXSGLVFQWG-- 541
           + G N++ QLG  +G     +VP  I   +  ++V+ +             G VF WG  
Sbjct: 98  TWGHNAYSQLG--NGTTNAGLVPYHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWGYN 155

Query: 542 -TGLASSGRRLCPGQTLPLFLTAKEP--SKVTG-LENSQAVCVLAGSGHSASLTDAGELY 709
            +G   SG             TA +P   +VTG L++   V +  G   S ++ + GE++
Sbjct: 156 NSGQVGSGS------------TANQPIPRRVTGCLQSKVVVNIACGQMCSMAVVNTGEVF 203

Query: 710 VWGSNKHGQLA-SQAAFLPLPQKIEAHRFQNEKVAAVWSGWTHLVAQTETGKVFTWGRAD 886
           VWG N +GQL    +   P P ++ A   Q  +V  V  G+ H +  T+ G+V+ WG   
Sbjct: 204 VWGYNGNGQLGLGSSGNQPTPCRVAA--LQGIRVQRVACGYAHTLVLTDEGQVYAWGANS 261

Query: 887 YGQLGRTLESPEGW 928
           YGQLG   +S + +
Sbjct: 262 YGQLGTGNKSNQSY 275



 Score = 84.7 bits (208), Expect = 2e-16
 Identities = 75/269 (27%), Positives = 111/269 (41%), Gaps = 7/269 (2%)
 Frame = +2

Query: 356  TKNGQVLSCGSNSFGQLGVPHGPRRCVVPQAIEVQREKVVSIXXXXXXXXXXXXS--GLV 529
            T N ++   G+N  G LG+    +  + P+ ++    K ++             +  G V
Sbjct: 38   TVNDEIFVLGTNCCGCLGLGD-VQSTIEPRRLDSLSGKKIACLSYGSGPHIVLATTEGEV 96

Query: 530  FQWGTGLASS-GRRLCPGQTLPLFLTAKEPSKVTGLENSQAVCVLAGSGHSASLTDAGEL 706
            F WG    S  G        +P  ++       T L N Q + V  GS HS  LT  GE+
Sbjct: 97   FTWGHNAYSQLGNGTTNAGLVPYHIS-------TNLSNKQVIEVACGSYHSLVLTSDGEV 149

Query: 707  YVWGSNKHGQLAS-QAAFLPLPQKIEAHRFQNEKVAAVWSGWTHLVAQTETGKVFTWGRA 883
            + WG N  GQ+ S   A  P+P+++     Q++ V  +  G    +A   TG+VF WG  
Sbjct: 150  FAWGYNNSGQVGSGSTANQPIPRRVTGC-LQSKVVVNIACGQMCSMAVVNTGEVFVWGYN 208

Query: 884  DYGQLGRTLESPEGWKPKKQASSLPCSRPARSVPSSLPCLTG--ATEVSCGSEHNLAVVG 1057
              GQLG       G +P                P  +  L G     V+CG  H L +  
Sbjct: 209  GNGQLGL---GSSGNQP---------------TPCRVAALQGIRVQRVACGYAHTLVLTD 250

Query: 1058 -GTCYSWGWNEHGMCGDGTEANVWTPKPV 1141
             G  Y+WG N +G  G G ++N   P PV
Sbjct: 251  EGQVYAWGANSYGQLGTGNKSNQSYPTPV 279



 Score = 80.1 bits (196), Expect = 4e-15
 Identities = 58/198 (29%), Positives = 86/198 (43%), Gaps = 3/198 (1%)
 Frame = +2

Query: 611  EPSKVTGLENSQAVCVLAGSG-HSASLTDAGELYVWGSNKHGQLASQAAFLPLPQKIEAH 787
            EP ++  L   +  C+  GSG H    T  GE++ WG N + QL +      L     + 
Sbjct: 64   EPRRLDSLSGKKIACLSYGSGPHIVLATTEGEVFTWGHNAYSQLGNGTTNAGLVPYHIST 123

Query: 788  RFQNEKVAAVWSGWTHLVAQTETGKVFTWGRADYGQLGRTLESPEGWKPKKQASSLPCSR 967
               N++V  V  G  H +  T  G+VF WG  + GQ+G               S    ++
Sbjct: 124  NLSNKQVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVG---------------SGSTANQ 168

Query: 968  PA-RSVPSSLPCLTGATEVSCGSEHNLAVVG-GTCYSWGWNEHGMCGDGTEANVWTPKPV 1141
            P  R V   L        ++CG   ++AVV  G  + WG+N +G  G G+  N  TP  V
Sbjct: 169  PIPRRVTGCLQSKV-VVNIACGQMCSMAVVNTGEVFVWGYNGNGQLGLGSSGNQPTPCRV 227

Query: 1142 QALRSSSGLRLGCGAGHS 1195
             AL+     R+ CG  H+
Sbjct: 228  AALQGIRVQRVACGYAHT 245



 Score = 77.8 bits (190), Expect = 2e-14
 Identities = 64/248 (25%), Positives = 98/248 (39%), Gaps = 12/248 (4%)
 Frame = +2

Query: 56  LFAWGANSYGQLGLGHKEDVLLPQQLSEFCKPGCVKRITGGGGHSAIVTDQGSLFVCGLN 235
           +F WG N+Y QLG G     L+P  +S       V  +  G  HS ++T  G +F  G N
Sbjct: 96  VFTWGHNAYSQLGNGTTNAGLVPYHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWGYN 155

Query: 236 KDGQLGLGHTEDVLYFTLCKSLLGC----PIQQVACGWDFTIILTKNGQVLSCGSNSFGQ 403
             GQ+G G T +     + + + GC     +  +ACG   ++ +   G+V   G N  GQ
Sbjct: 156 NSGQVGSGSTANQ---PIPRRVTGCLQSKVVVNIACGQMCSMAVVNTGEVFVWGYNGNGQ 212

Query: 404 LGVPHG-----PRRCVVPQAIEVQREKVVSIXXXXXXXXXXXXSGLVFQWGT---GLASS 559
           LG+        P R    Q I VQR     +             G V+ WG    G   +
Sbjct: 213 LGLGSSGNQPTPCRVAALQGIRVQR-----VACGYAHTLVLTDEGQVYAWGANSYGQLGT 267

Query: 560 GRRLCPGQTLPLFLTAKEPSKVTGLENSQAVCVLAGSGHSASLTDAGELYVWGSNKHGQL 739
           G +       P+ +      ++    ++           SA+ T  G +Y+W     GQ 
Sbjct: 268 GNKSNQSYPTPVVVEKDRIIEIAACHSAHT---------SAAKTQGGHVYMW-----GQC 313

Query: 740 ASQAAFLP 763
             Q+  LP
Sbjct: 314 RGQSVTLP 321


>ref|XP_002691829.1| PREDICTED: regulator of chromosome condensation (RCC1) and BTB
           (POZ) domain containing protein 2 [Bos taurus].
          Length = 527

 Score =  107 bits (268), Expect = 2e-23
 Identities = 83/287 (28%), Positives = 131/287 (45%), Gaps = 12/287 (4%)
 Frame = +2

Query: 56  LFAWGANSYGQLGLGHKEDVLLPQQLSEFCKPGCVKRITGGGGHSAIVTDQGSLFVCGLN 235
           +F  G N  G LGLG  +  + P++L             G G H  + T +G +F  G N
Sbjct: 43  IFVLGTNCCGCLGLGDVQSTIEPRRLDSLSGKKIACLSYGSGPHIVLATTEGEVFTWGHN 102

Query: 236 KDGQLGLGHTE-DVLYFTLCKSLLGCPIQQVACGWDFTIILTKNGQVLSCGSNSFGQLGV 412
              QLG G T   ++ + +  +L    + +VACG   +++LT +G+V + G N+ GQ+G 
Sbjct: 103 AYSQLGNGTTNAGLVPYHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGS 162

Query: 413 PHGPRRCVVPQAIE--VQREKVVSIXXXXXXXXXXXXSGLVFQWG------TGLASSGRR 568
                +  +P+ +   +Q + VV+I            +G VF WG       GL SSG +
Sbjct: 163 GSTANQ-PIPRRVTGCLQSKVVVNIACGQMCSMAVVNTGEVFVWGYNGNGQLGLGSSGNQ 221

Query: 569 LCPGQTLPLFLTAKEPSKVTGLENSQAVCVLAGSGHSASLTDAGELYVWGSNKHGQLAS- 745
                          P +V  L+  +   V  G  H+  LTD G++Y WG+N +GQL + 
Sbjct: 222 -------------PTPCRVAALQGIRVQRVACGYAHTLVLTDEGQVYAWGANSYGQLGTG 268

Query: 746 --QAAFLPLPQKIEAHRFQNEKVAAVWSGWTHLVAQTETGKVFTWGR 880
                  P P  +E  R    ++AA  S  T   A+T+ G V+ WG+
Sbjct: 269 NKSNQSYPTPVVVEKDRI--IEIAACHSAHTS-AAKTQGGHVYMWGQ 312



 Score = 87.8 bits (216), Expect = 2e-17
 Identities = 76/254 (29%), Positives = 117/254 (46%), Gaps = 11/254 (4%)
 Frame = +2

Query: 200 TDQGSLFVCGLNKDGQLGLGHTEDVLYFTLCKSLLGCPIQQVACGWDFTIIL-TKNGQVL 376
           T    +FV G N  G LGLG  +  +      SL G  I  ++ G    I+L T  G+V 
Sbjct: 38  TVNDEIFVLGTNCCGCLGLGDVQSTIEPRRLDSLSGKKIACLSYGSGPHIVLATTEGEVF 97

Query: 377 SCGSNSFGQLGVPHGPRRC-VVPQAIE--VQREKVVSIXXXXXXXXXXXXSGLVFQWG-- 541
           + G N++ QLG  +G     +VP  I   +  ++V+ +             G VF WG  
Sbjct: 98  TWGHNAYSQLG--NGTTNAGLVPYHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWGYN 155

Query: 542 -TGLASSGRRLCPGQTLPLFLTAKEP--SKVTG-LENSQAVCVLAGSGHSASLTDAGELY 709
            +G   SG             TA +P   +VTG L++   V +  G   S ++ + GE++
Sbjct: 156 NSGQVGSGS------------TANQPIPRRVTGCLQSKVVVNIACGQMCSMAVVNTGEVF 203

Query: 710 VWGSNKHGQLA-SQAAFLPLPQKIEAHRFQNEKVAAVWSGWTHLVAQTETGKVFTWGRAD 886
           VWG N +GQL    +   P P ++ A   Q  +V  V  G+ H +  T+ G+V+ WG   
Sbjct: 204 VWGYNGNGQLGLGSSGNQPTPCRVAA--LQGIRVQRVACGYAHTLVLTDEGQVYAWGANS 261

Query: 887 YGQLGRTLESPEGW 928
           YGQLG   +S + +
Sbjct: 262 YGQLGTGNKSNQSY 275



 Score = 84.7 bits (208), Expect = 2e-16
 Identities = 75/269 (27%), Positives = 111/269 (41%), Gaps = 7/269 (2%)
 Frame = +2

Query: 356  TKNGQVLSCGSNSFGQLGVPHGPRRCVVPQAIEVQREKVVSIXXXXXXXXXXXXS--GLV 529
            T N ++   G+N  G LG+    +  + P+ ++    K ++             +  G V
Sbjct: 38   TVNDEIFVLGTNCCGCLGLGD-VQSTIEPRRLDSLSGKKIACLSYGSGPHIVLATTEGEV 96

Query: 530  FQWGTGLASS-GRRLCPGQTLPLFLTAKEPSKVTGLENSQAVCVLAGSGHSASLTDAGEL 706
            F WG    S  G        +P  ++       T L N Q + V  GS HS  LT  GE+
Sbjct: 97   FTWGHNAYSQLGNGTTNAGLVPYHIS-------TNLSNKQVIEVACGSYHSLVLTSDGEV 149

Query: 707  YVWGSNKHGQLAS-QAAFLPLPQKIEAHRFQNEKVAAVWSGWTHLVAQTETGKVFTWGRA 883
            + WG N  GQ+ S   A  P+P+++     Q++ V  +  G    +A   TG+VF WG  
Sbjct: 150  FAWGYNNSGQVGSGSTANQPIPRRVTGC-LQSKVVVNIACGQMCSMAVVNTGEVFVWGYN 208

Query: 884  DYGQLGRTLESPEGWKPKKQASSLPCSRPARSVPSSLPCLTG--ATEVSCGSEHNLAVVG 1057
              GQLG       G +P                P  +  L G     V+CG  H L +  
Sbjct: 209  GNGQLGL---GSSGNQP---------------TPCRVAALQGIRVQRVACGYAHTLVLTD 250

Query: 1058 -GTCYSWGWNEHGMCGDGTEANVWTPKPV 1141
             G  Y+WG N +G  G G ++N   P PV
Sbjct: 251  EGQVYAWGANSYGQLGTGNKSNQSYPTPV 279



 Score = 80.1 bits (196), Expect = 4e-15
 Identities = 58/198 (29%), Positives = 86/198 (43%), Gaps = 3/198 (1%)
 Frame = +2

Query: 611  EPSKVTGLENSQAVCVLAGSG-HSASLTDAGELYVWGSNKHGQLASQAAFLPLPQKIEAH 787
            EP ++  L   +  C+  GSG H    T  GE++ WG N + QL +      L     + 
Sbjct: 64   EPRRLDSLSGKKIACLSYGSGPHIVLATTEGEVFTWGHNAYSQLGNGTTNAGLVPYHIST 123

Query: 788  RFQNEKVAAVWSGWTHLVAQTETGKVFTWGRADYGQLGRTLESPEGWKPKKQASSLPCSR 967
               N++V  V  G  H +  T  G+VF WG  + GQ+G               S    ++
Sbjct: 124  NLSNKQVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVG---------------SGSTANQ 168

Query: 968  PA-RSVPSSLPCLTGATEVSCGSEHNLAVVG-GTCYSWGWNEHGMCGDGTEANVWTPKPV 1141
            P  R V   L        ++CG   ++AVV  G  + WG+N +G  G G+  N  TP  V
Sbjct: 169  PIPRRVTGCLQSKV-VVNIACGQMCSMAVVNTGEVFVWGYNGNGQLGLGSSGNQPTPCRV 227

Query: 1142 QALRSSSGLRLGCGAGHS 1195
             AL+     R+ CG  H+
Sbjct: 228  AALQGIRVQRVACGYAHT 245



 Score = 77.8 bits (190), Expect = 2e-14
 Identities = 64/248 (25%), Positives = 98/248 (39%), Gaps = 12/248 (4%)
 Frame = +2

Query: 56  LFAWGANSYGQLGLGHKEDVLLPQQLSEFCKPGCVKRITGGGGHSAIVTDQGSLFVCGLN 235
           +F WG N+Y QLG G     L+P  +S       V  +  G  HS ++T  G +F  G N
Sbjct: 96  VFTWGHNAYSQLGNGTTNAGLVPYHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWGYN 155

Query: 236 KDGQLGLGHTEDVLYFTLCKSLLGC----PIQQVACGWDFTIILTKNGQVLSCGSNSFGQ 403
             GQ+G G T +     + + + GC     +  +ACG   ++ +   G+V   G N  GQ
Sbjct: 156 NSGQVGSGSTANQ---PIPRRVTGCLQSKVVVNIACGQMCSMAVVNTGEVFVWGYNGNGQ 212

Query: 404 LGVPHG-----PRRCVVPQAIEVQREKVVSIXXXXXXXXXXXXSGLVFQWGT---GLASS 559
           LG+        P R    Q I VQR     +             G V+ WG    G   +
Sbjct: 213 LGLGSSGNQPTPCRVAALQGIRVQR-----VACGYAHTLVLTDEGQVYAWGANSYGQLGT 267

Query: 560 GRRLCPGQTLPLFLTAKEPSKVTGLENSQAVCVLAGSGHSASLTDAGELYVWGSNKHGQL 739
           G +       P+ +      ++    ++           SA+ T  G +Y+W     GQ 
Sbjct: 268 GNKSNQSYPTPVVVEKDRIIEIAACHSAHT---------SAAKTQGGHVYMW-----GQC 313

Query: 740 ASQAAFLP 763
             Q+  LP
Sbjct: 314 RGQSVTLP 321


>ref|NP_001178141.1| RCC1 and BTB domain-containing protein 1 [Bos taurus].
          Length = 531

 Score =  103 bits (256), Expect = 4e-22
 Identities = 82/286 (28%), Positives = 128/286 (44%), Gaps = 11/286 (3%)
 Frame = +2

Query: 56  LFAWGANSYGQLGLGHKEDVLLPQQLSEFCKPGCVKRITGGGGHSAIVTDQGSLFVCGLN 235
           +F +G N    LG G     L+P++L   C         G G H  + T+ G ++  G N
Sbjct: 43  VFVFGLNYSSCLGTGDNHSTLVPKKLEALCGKKIKSLSYGSGPHVLLSTEDGVVYAWGHN 102

Query: 236 KDGQLGLGHTEDVLY-FTLCKSLLGCPIQQVACGWDFTIILTKNGQVLSCGSNSFGQLG- 409
              QLG G T   L    +C +LL   + +VACG   ++ L  +G+V + G N+ GQ+G 
Sbjct: 103 GYSQLGNGTTNQGLAPIQVCTNLLIKQVVEVACGSHHSMALAADGEVFAWGYNNCGQVGS 162

Query: 410 --VPHGPRRCVVPQAIEVQREKVVSIXXXXXXXXXXXXSGLVFQWG------TGLASSGR 565
               + P    V   + ++R  VV I            +G V+ WG       GL ++G 
Sbjct: 163 GSTANQPTPRKVTNCLHIKR--VVGIACGQTSSMAVLDNGEVYGWGYNGNGQLGLGNNGN 220

Query: 566 RLCPGQTLPLFLTAKEPSKVTGLENSQAVCVLAGSGHSASLTDAGELYVWGSNKHGQLAS 745
           +L              P +V  L +     ++ G  H+ +LTD G LY WG+N +GQL +
Sbjct: 221 QL-------------TPVRVAALHSVCVNQIVCGYAHTLALTDEGLLYAWGANTYGQLGT 267

Query: 746 -QAAFLPLPQKIEAHRFQNEKVAAVWSGWTHLVAQTETGKVFTWGR 880
                L  P  I   + +  ++AA  S  T   A+T+ G V+ WG+
Sbjct: 268 GNKNNLLSPAHIMVEKERVIEIAACHSAHTS-AAKTQGGHVYMWGQ 312



 Score = 79.7 bits (195), Expect = 5e-15
 Identities = 55/185 (29%), Positives = 90/185 (48%), Gaps = 5/185 (2%)
 Frame = +2

Query: 56  LFAWGANSYGQLGLGHKEDVLLPQQLSEFCKPGCVKRITG---GGGHSAIVTDQGSLFVC 226
           +FAWG N+ GQ+G G   +   P++++       +KR+ G   G   S  V D G ++  
Sbjct: 149 VFAWGYNNCGQVGSGSTANQPTPRKVTNCLH---IKRVVGIACGQTSSMAVLDNGEVYGW 205

Query: 227 GLNKDGQLGLGHTEDVLYFTLCKSLLGCPIQQVACGWDFTIILTKNGQVLSCGSNSFGQL 406
           G N +GQLGLG+  + L      +L    + Q+ CG+  T+ LT  G + + G+N++GQL
Sbjct: 206 GYNGNGQLGLGNNGNQLTPVRVAALHSVCVNQIVCGYAHTLALTDEGLLYAWGANTYGQL 265

Query: 407 GVPHGPRRCVVPQAIEVQREKVVSIXXXXXXXXXXXXS--GLVFQWGTGLASSGRRLCPG 580
           G  +     + P  I V++E+V+ I            +  G V+ WG          C G
Sbjct: 266 GTGN-KNNLLSPAHIMVEKERVIEIAACHSAHTSAAKTQGGHVYMWGQ---------CRG 315

Query: 581 QTLPL 595
           Q++ L
Sbjct: 316 QSVTL 320



 Score = 77.0 bits (188), Expect = 3e-14
 Identities = 79/275 (28%), Positives = 120/275 (43%), Gaps = 12/275 (4%)
 Frame = +2

Query: 113 VLLPQQLSEFCKPGCVKRITGGGGHSAI-VTDQGSLFVCGLNKDGQLGLGHTEDVLYFTL 289
           +L P +++   K  CV    G   + A+ VTD   +FV GLN    LG G     L    
Sbjct: 12  LLSPHEIASIRK-ACV---FGTSANEALYVTDSDEVFVFGLNYSSCLGTGDNHSTLVPKK 67

Query: 290 CKSLLGCPIQQVACGWDFTIIL-TKNGQVLSCGSNSFGQLGVPHGPRR---CVVPQAIEV 457
            ++L G  I+ ++ G    ++L T++G V + G N + QLG  +G        +     +
Sbjct: 68  LEALCGKKIKSLSYGSGPHVLLSTEDGVVYAWGHNGYSQLG--NGTTNQGLAPIQVCTNL 125

Query: 458 QREKVVSIXXXXXXXXXXXXSGLVFQWG---TGLASSGRRLCPGQTLPLFLTAKEPS--K 622
             ++VV +             G VF WG    G   SG             TA +P+  K
Sbjct: 126 LIKQVVEVACGSHHSMALAADGEVFAWGYNNCGQVGSGS------------TANQPTPRK 173

Query: 623 VTG-LENSQAVCVLAGSGHSASLTDAGELYVWGSNKHGQLASQAAFLPL-PQKIEAHRFQ 796
           VT  L   + V +  G   S ++ D GE+Y WG N +GQL        L P ++ A    
Sbjct: 174 VTNCLHIKRVVGIACGQTSSMAVLDNGEVYGWGYNGNGQLGLGNNGNQLTPVRVAA--LH 231

Query: 797 NEKVAAVWSGWTHLVAQTETGKVFTWGRADYGQLG 901
           +  V  +  G+ H +A T+ G ++ WG   YGQLG
Sbjct: 232 SVCVNQIVCGYAHTLALTDEGLLYAWGANTYGQLG 266



 Score = 71.6 bits (174), Expect = 1e-12
 Identities = 57/198 (28%), Positives = 82/198 (41%), Gaps = 4/198 (2%)
 Frame = +2

Query: 614  PSKVTGLENSQAVCVLAGSG-HSASLTDAGELYVWGSNKHGQLASQAAFLPLPQKIEAHR 790
            P K+  L   +   +  GSG H    T+ G +Y WG N + QL +      L        
Sbjct: 65   PKKLEALCGKKIKSLSYGSGPHVLLSTEDGVVYAWGHNGYSQLGNGTTNQGLAPIQVCTN 124

Query: 791  FQNEKVAAVWSGWTHLVAQTETGKVFTWGRADYGQLGR--TLESPEGWKPKKQASSLPCS 964
               ++V  V  G  H +A    G+VF WG  + GQ+G   T   P    P+K  + L   
Sbjct: 125  LLIKQVVEVACGSHHSMALAADGEVFAWGYNNCGQVGSGSTANQPT---PRKVTNCLHIK 181

Query: 965  RPARSVPSSLPCLTGATEVSCGSEHNLAVV-GGTCYSWGWNEHGMCGDGTEANVWTPKPV 1141
            R                 ++CG   ++AV+  G  Y WG+N +G  G G   N  TP  V
Sbjct: 182  R--------------VVGIACGQTSSMAVLDNGEVYGWGYNGNGQLGLGNNGNQLTPVRV 227

Query: 1142 QALRSSSGLRLGCGAGHS 1195
             AL S    ++ CG  H+
Sbjct: 228  AALHSVCVNQIVCGYAHT 245


>ref|XP_002691834.1| PREDICTED: regulator of chromosome condensation (RCC1) and BTB
           (POZ) domain containing protein 1 [Bos taurus].
          Length = 531

 Score =  103 bits (256), Expect = 4e-22
 Identities = 82/286 (28%), Positives = 128/286 (44%), Gaps = 11/286 (3%)
 Frame = +2

Query: 56  LFAWGANSYGQLGLGHKEDVLLPQQLSEFCKPGCVKRITGGGGHSAIVTDQGSLFVCGLN 235
           +F +G N    LG G     L+P++L   C         G G H  + T+ G ++  G N
Sbjct: 43  VFVFGLNYSSCLGTGDNHSTLVPKKLEALCGKKIKSLSYGSGPHVLLSTEDGVVYAWGHN 102

Query: 236 KDGQLGLGHTEDVLY-FTLCKSLLGCPIQQVACGWDFTIILTKNGQVLSCGSNSFGQLG- 409
              QLG G T   L    +C +LL   + +VACG   ++ L  +G+V + G N+ GQ+G 
Sbjct: 103 GYSQLGNGTTNQGLAPIQVCTNLLIKQVVEVACGSHHSMALAADGEVFAWGYNNCGQVGS 162

Query: 410 --VPHGPRRCVVPQAIEVQREKVVSIXXXXXXXXXXXXSGLVFQWG------TGLASSGR 565
               + P    V   + ++R  VV I            +G V+ WG       GL ++G 
Sbjct: 163 GSTANQPTPRKVTNCLHIKR--VVGIACGQTSSMAVLDNGEVYGWGYNGNGQLGLGNNGN 220

Query: 566 RLCPGQTLPLFLTAKEPSKVTGLENSQAVCVLAGSGHSASLTDAGELYVWGSNKHGQLAS 745
           +L              P +V  L +     ++ G  H+ +LTD G LY WG+N +GQL +
Sbjct: 221 QL-------------TPVRVAALHSVCVNQIVCGYAHTLALTDEGLLYAWGANTYGQLGT 267

Query: 746 -QAAFLPLPQKIEAHRFQNEKVAAVWSGWTHLVAQTETGKVFTWGR 880
                L  P  I   + +  ++AA  S  T   A+T+ G V+ WG+
Sbjct: 268 GNKNNLLSPAHIMVEKERVIEIAACHSAHTS-AAKTQGGHVYMWGQ 312



 Score = 79.7 bits (195), Expect = 5e-15
 Identities = 55/185 (29%), Positives = 90/185 (48%), Gaps = 5/185 (2%)
 Frame = +2

Query: 56  LFAWGANSYGQLGLGHKEDVLLPQQLSEFCKPGCVKRITG---GGGHSAIVTDQGSLFVC 226
           +FAWG N+ GQ+G G   +   P++++       +KR+ G   G   S  V D G ++  
Sbjct: 149 VFAWGYNNCGQVGSGSTANQPTPRKVTNCLH---IKRVVGIACGQTSSMAVLDNGEVYGW 205

Query: 227 GLNKDGQLGLGHTEDVLYFTLCKSLLGCPIQQVACGWDFTIILTKNGQVLSCGSNSFGQL 406
           G N +GQLGLG+  + L      +L    + Q+ CG+  T+ LT  G + + G+N++GQL
Sbjct: 206 GYNGNGQLGLGNNGNQLTPVRVAALHSVCVNQIVCGYAHTLALTDEGLLYAWGANTYGQL 265

Query: 407 GVPHGPRRCVVPQAIEVQREKVVSIXXXXXXXXXXXXS--GLVFQWGTGLASSGRRLCPG 580
           G  +     + P  I V++E+V+ I            +  G V+ WG          C G
Sbjct: 266 GTGN-KNNLLSPAHIMVEKERVIEIAACHSAHTSAAKTQGGHVYMWGQ---------CRG 315

Query: 581 QTLPL 595
           Q++ L
Sbjct: 316 QSVTL 320



 Score = 77.0 bits (188), Expect = 3e-14
 Identities = 79/275 (28%), Positives = 120/275 (43%), Gaps = 12/275 (4%)
 Frame = +2

Query: 113 VLLPQQLSEFCKPGCVKRITGGGGHSAI-VTDQGSLFVCGLNKDGQLGLGHTEDVLYFTL 289
           +L P +++   K  CV    G   + A+ VTD   +FV GLN    LG G     L    
Sbjct: 12  LLSPHEIASIRK-ACV---FGTSANEALYVTDSDEVFVFGLNYSSCLGTGDNHSTLVPKK 67

Query: 290 CKSLLGCPIQQVACGWDFTIIL-TKNGQVLSCGSNSFGQLGVPHGPRR---CVVPQAIEV 457
            ++L G  I+ ++ G    ++L T++G V + G N + QLG  +G        +     +
Sbjct: 68  LEALCGKKIKSLSYGSGPHVLLSTEDGVVYAWGHNGYSQLG--NGTTNQGLAPIQVCTNL 125

Query: 458 QREKVVSIXXXXXXXXXXXXSGLVFQWG---TGLASSGRRLCPGQTLPLFLTAKEPS--K 622
             ++VV +             G VF WG    G   SG             TA +P+  K
Sbjct: 126 LIKQVVEVACGSHHSMALAADGEVFAWGYNNCGQVGSGS------------TANQPTPRK 173

Query: 623 VTG-LENSQAVCVLAGSGHSASLTDAGELYVWGSNKHGQLASQAAFLPL-PQKIEAHRFQ 796
           VT  L   + V +  G   S ++ D GE+Y WG N +GQL        L P ++ A    
Sbjct: 174 VTNCLHIKRVVGIACGQTSSMAVLDNGEVYGWGYNGNGQLGLGNNGNQLTPVRVAA--LH 231

Query: 797 NEKVAAVWSGWTHLVAQTETGKVFTWGRADYGQLG 901
           +  V  +  G+ H +A T+ G ++ WG   YGQLG
Sbjct: 232 SVCVNQIVCGYAHTLALTDEGLLYAWGANTYGQLG 266



 Score = 71.6 bits (174), Expect = 1e-12
 Identities = 57/198 (28%), Positives = 82/198 (41%), Gaps = 4/198 (2%)
 Frame = +2

Query: 614  PSKVTGLENSQAVCVLAGSG-HSASLTDAGELYVWGSNKHGQLASQAAFLPLPQKIEAHR 790
            P K+  L   +   +  GSG H    T+ G +Y WG N + QL +      L        
Sbjct: 65   PKKLEALCGKKIKSLSYGSGPHVLLSTEDGVVYAWGHNGYSQLGNGTTNQGLAPIQVCTN 124

Query: 791  FQNEKVAAVWSGWTHLVAQTETGKVFTWGRADYGQLGR--TLESPEGWKPKKQASSLPCS 964
               ++V  V  G  H +A    G+VF WG  + GQ+G   T   P    P+K  + L   
Sbjct: 125  LLIKQVVEVACGSHHSMALAADGEVFAWGYNNCGQVGSGSTANQPT---PRKVTNCLHIK 181

Query: 965  RPARSVPSSLPCLTGATEVSCGSEHNLAVV-GGTCYSWGWNEHGMCGDGTEANVWTPKPV 1141
            R                 ++CG   ++AV+  G  Y WG+N +G  G G   N  TP  V
Sbjct: 182  R--------------VVGIACGQTSSMAVLDNGEVYGWGYNGNGQLGLGNNGNQLTPVRV 227

Query: 1142 QALRSSSGLRLGCGAGHS 1195
             AL S    ++ CG  H+
Sbjct: 228  AALHSVCVNQIVCGYAHT 245


>ref|NP_001179573.1| probable E3 ubiquitin-protein ligase HERC6 [Bos taurus].
          Length = 1016

 Score =  102 bits (253), Expect = 9e-22
 Identities = 83/316 (26%), Positives = 135/316 (42%), Gaps = 5/316 (1%)
 Frame = +2

Query: 122  PQQLSEFCKPG-CVKRITGGGGHSAIVTDQGSLFVCGLNKDGQLGLGHTEDVLYFTLCKS 298
            P +  + C  G  + +   G  HS ++   G++  CG N  GQLG   T          +
Sbjct: 12   PLRERQVCAGGNTLLQAASGEHHSLLLLSDGTVQSCGDNSRGQLGRKGTPRGEQPERIPA 71

Query: 299  LLGCPIQQVACGWDFTIILTKNGQVLSCGSNSFGQLGVPHGPRRCVVPQAIEVQRE-KVV 475
            L    +  V+CG + ++ +   G+V + G+ S GQLG+        +P+ I+     K++
Sbjct: 72   LETLNVALVSCGKEHSLAVCHKGRVFAWGAASEGQLGIGEFKETTFIPKKIKTLAGIKII 131

Query: 476  SIXXXXXXXXXXXXSGLVFQWGTGLASSGRRLCPGQTLPLFLTAKEPSKVTGLENSQAVC 655
             +             G VF WGT   +S  +L  G+  P   +   P +V  LE      
Sbjct: 132  QVACGHYHSVALSEDGQVFSWGT---NSHGQLGLGKEFP---SQASPQRVRSLEGIPLAQ 185

Query: 656  VLAGSGHSASLTDAGELYVWGSNKHGQLASQAAFLPLPQ--KIEAHRFQNEKVAAVWSGW 829
            V AG  HS +L+ +G  + WGSN  GQLA      P+ +   +     +   V ++  G+
Sbjct: 186  VAAGGHHSFALSLSGTSFGWGSNSAGQLALSGNNAPVQRYKPVSIGALKTLGVVSISCGY 245

Query: 830  THLVAQTETGKVFTWGRADYGQLGRTLESPEGWKPKKQASSLPCSRPARSVPSSLPCLTG 1009
             H    T+ GKVFT+G   YGQLG    +                   +  P  +  + G
Sbjct: 246  KHTAVLTQDGKVFTFGDNSYGQLGHDPTAE------------------KRGPQLVERIEG 287

Query: 1010 -ATEVSCGSEHNLAVV 1054
              +++ CGS+H LA +
Sbjct: 288  LVSQIDCGSDHTLAYI 303



 Score = 94.0 bits (232), Expect = 3e-19
 Identities = 88/309 (28%), Positives = 141/309 (45%), Gaps = 4/309 (1%)
 Frame = +2

Query: 68  GANSYGQLGLGHKEDVLLPQQLSEFCKPGCVKRITGGGGHSAIVTDQGSLFVCGLNKDGQ 247
           G NS GQLG         P+++    +   V  ++ G  HS  V  +G +F  G   +GQ
Sbjct: 48  GDNSRGQLGRKGTPRGEQPERIPAL-ETLNVALVSCGKEHSLAVCHKGRVFAWGAASEGQ 106

Query: 248 LGLGHTEDVLYFTL-CKSLLGCPIQQVACGWDFTIILTKNGQVLSCGSNSFGQLGVPHGP 424
           LG+G  ++  +     K+L G  I QVACG   ++ L+++GQV S G+NS GQLG+    
Sbjct: 107 LGIGEFKETTFIPKKIKTLAGIKIIQVACGHYHSVALSEDGQVFSWGTNSHGQLGLGKEF 166

Query: 425 RRCVVPQAI-EVQREKVVSIXXXXXXXXXXXXSGLVFQWGTGLASSGRRLCPGQTLPLFL 601
                PQ +  ++   +  +            SG  F WG+   S+G+    G   P  +
Sbjct: 167 PSQASPQRVRSLEGIPLAQVAAGGHHSFALSLSGTSFGWGSN--SAGQLALSGNNAP--V 222

Query: 602 TAKEPSKVTGLENSQAVCVLAGSGHSASLTDAGELYVWGSNKHGQLA-SQAAFLPLPQKI 778
              +P  +  L+    V +  G  H+A LT  G+++ +G N +GQL     A    PQ +
Sbjct: 223 QRYKPVSIGALKTLGVVSISCGYKHTAVLTQDGKVFTFGDNSYGQLGHDPTAEKRGPQLV 282

Query: 779 EAHRFQNEKVAAVWSGWTHLVAQT-ETGKVFTWGRADYGQLGRTLESPEGWKPKKQASSL 955
           E  R +   V+ +  G  H +A    TG+V ++GR      G    SP    P  ++S +
Sbjct: 283 E--RIEG-LVSQIDCGSDHTLAYIYTTGQVVSFGRGP----GCASRSPH---PGAESSDI 332

Query: 956 PCSRPARSV 982
            C   A+ +
Sbjct: 333 SCLVSAKDL 341



 Score = 92.4 bits (228), Expect = 7e-19
 Identities = 77/298 (25%), Positives = 123/298 (41%), Gaps = 1/298 (0%)
 Frame = +2

Query: 305  GCPIQQVACGWDFTIILTKNGQVLSCGSNSFGQLGVPHGPRRCVVPQAIEVQREKVVSIX 484
            G  + Q A G   +++L  +G V SCG NS GQLG    PR     +   ++   V  + 
Sbjct: 22   GNTLLQAASGEHHSLLLLSDGTVQSCGDNSRGQLGRKGTPRGEQPERIPALETLNVALVS 81

Query: 485  XXXXXXXXXXXSGLVFQWGTGLASSGRRLCPGQTLPLFLTAKEPSKVTGLENSQAVCVLA 664
                        G VF WG   A+S  +L  G+        K+   + G++  Q  C   
Sbjct: 82   CGKEHSLAVCHKGRVFAWG---AASEGQLGIGEFKETTFIPKKIKTLAGIKIIQVAC--- 135

Query: 665  GSGHSASLTDAGELYVWGSNKHGQLASQAAFLPLPQKIEAHRFQNEKVAAVWSGWTHLVA 844
            G  HS +L++ G+++ WG+N HGQL     F            +   +A V +G  H  A
Sbjct: 136  GHYHSVALSEDGQVFSWGTNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGHHSFA 195

Query: 845  QTETGKVFTWGRADYGQLGRTLESPEGWKPKKQASSLPCSRPARSVPSSLPCLTGATEVS 1024
             + +G  F WG    GQL  +             ++ P  R       +L  L G   +S
Sbjct: 196  LSLSGTSFGWGSNSAGQLALS------------GNNAPVQRYKPVSIGALKTL-GVVSIS 242

Query: 1025 CGSEHNLAVV-GGTCYSWGWNEHGMCGDGTEANVWTPKPVQALRSSSGLRLGCGAGHS 1195
            CG +H   +   G  +++G N +G  G    A    P+ V+ +      ++ CG+ H+
Sbjct: 243  CGYKHTAVLTQDGKVFTFGDNSYGQLGHDPTAEKRGPQLVERIEGLVS-QIDCGSDHT 299



 Score = 68.6 bits (166), Expect = 1e-11
 Identities = 43/126 (34%), Positives = 67/126 (53%), Gaps = 3/126 (2%)
 Frame = +2

Query: 56  LFAWGANSYGQLGLGHKEDVLLPQQLSEFCKPGCVKRITGGGGHSAIVTDQGSLFVCGLN 235
           +F+WG NS+GQLGLG +       Q     +   + ++  GG HS  ++  G+ F  G N
Sbjct: 149 VFSWGTNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGHHSFALSLSGTSFGWGSN 208

Query: 236 KDGQLGL-GHTEDVLYF--TLCKSLLGCPIQQVACGWDFTIILTKNGQVLSCGSNSFGQL 406
             GQL L G+   V  +      +L    +  ++CG+  T +LT++G+V + G NS+GQL
Sbjct: 209 SAGQLALSGNNAPVQRYKPVSIGALKTLGVVSISCGYKHTAVLTQDGKVFTFGDNSYGQL 268

Query: 407 GVPHGP 424
           G  H P
Sbjct: 269 G--HDP 272


  Database: RefSeq49_BP.fasta
    Posted date:  Oct 17, 2011  1:42 PM
  Number of letters in database: 17,681,374
  Number of sequences in database:  33,088
  
Lambda     K      H
   0.318    0.134    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 33088
Number of Hits to DB: 57,044,164
Number of extensions: 1833205
Number of successful extensions: 7869
Number of sequences better than 1.0e-05: 31
Number of HSP's gapped: 7372
Number of HSP's successfully gapped: 125
Length of query: 421
Length of database: 17,681,374
Length adjustment: 105
Effective length of query: 316
Effective length of database: 14,207,134
Effective search space: 4489454344
Effective search space used: 4489454344
Neighboring words threshold: 12
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 35 (18.1 bits)

BLASTX 2.2.24 [Aug-08-2010]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= 20110601C-004015
         (1263 letters)

Database: RefSeq49_CP.fasta 
           33,336 sequences; 18,874,504 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

Alignment   gi|XP_535653.2| PREDICTED: similar to HECT domain and RCC1-like...   134   2e-31
Alignment   gi|XP_867304.1| PREDICTED: similar to hect domain and RLD 2 iso...   124   1e-28
Alignment   gi|XP_536160.2| PREDICTED: similar to hect domain and RLD 2 iso...   124   1e-28
Alignment   gi|XP_536367.2| PREDICTED: similar to hect domain and RLD 4 iso...   123   4e-28
Alignment   gi|XP_860046.1| PREDICTED: similar to hect domain and RLD 4 iso...   123   4e-28
Alignment   gi|XP_860006.1| PREDICTED: similar to hect domain and RLD 4 iso...   123   4e-28
Alignment   gi|XP_859968.1| PREDICTED: similar to hect domain and RLD 4 iso...   123   4e-28
Alignment   gi|XP_859933.1| PREDICTED: similar to hect domain and RLD 4 iso...   123   4e-28
Alignment   gi|XP_859900.1| PREDICTED: similar to hect domain and RLD 4 iso...   123   4e-28
Alignment   gi|XP_859830.1| PREDICTED: similar to hect domain and RLD 4 iso...   123   4e-28

>ref|XP_535653.2| PREDICTED: similar to HECT domain and RCC1-like domain protein 3
            [Canis familiaris].
          Length = 1051

 Score =  134 bits (336), Expect = 2e-31
 Identities = 102/367 (27%), Positives = 158/367 (43%), Gaps = 4/367 (1%)
 Frame = +2

Query: 56   LFAWGANSYGQLGLG-HKEDVLLPQQLSEFCKPGCVKRITGGGGHSAIVTDQGSLFVCGL 232
            +  WG  S GQ G+  + + ++   Q+  F     VK +  GG HS  + + G ++ CGL
Sbjct: 1    MLCWGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGNHSVFLLEDGEVYTCGL 60

Query: 233  NKDGQLGLGHTEDVLYFTLCKSLLGCPIQQVACGWDFTIILTKNGQVLSCGSNSFGQLGV 412
            N  GQ  LGH  +        +L    I  VACG   ++ L+  GQ+ S G+ S GQLG+
Sbjct: 61   NTKGQ--LGHEREGNKPEQIGALADQHIVHVACGESHSLALSDRGQLFSWGAGSDGQLGL 118

Query: 413  PHGPRRCVVPQAIE-VQREKVVSIXXXXXXXXXXXXSGLVFQWGTGLASSGRRLCPGQTL 589
                    VP+ I+ + ++ ++ +             G  F WG    +S  +L  G+  
Sbjct: 119  MTTEDSVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWG---KNSHGQLGLGKEY 175

Query: 590  PLFLTAKEPSKVTGLENSQAVCVLAGSGHSASLTDAGELYVWGSNKHGQLASQAAFLPLP 769
            P   +   P +V  LE      V AG  HS +L+ +G ++ WG N  GQL          
Sbjct: 176  P---SQASPQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEEGNRE 232

Query: 770  QKIEAHRFQNEKVAAVWSGWTHLVAQTETGKVFTWGRADYGQLGRTLESPEGWKPKKQAS 949
                    + +KV  +  G  H    T++G VFT+G    GQLG    + E   P++   
Sbjct: 233  SPCHVKLLRTQKVVYISCGEEHTAVLTKSGGVFTFGAGSCGQLGHDSMNDE-VNPRRVLE 291

Query: 950  SLPCSRPARSVPSSLPCLTGATEVSCGSEHNLAVV--GGTCYSWGWNEHGMCGDGTEANV 1123
             +                +  T+++CG +H LA V   G  Y++G    G  G G   NV
Sbjct: 292  LMG---------------SEVTQIACGRQHTLAFVPSSGLIYAFGCGAKGQLGTGHTCNV 336

Query: 1124 WTPKPVQ 1144
              P PV+
Sbjct: 337  KCPSPVK 343



 Score = 62.8 bits (151), Expect = 7e-10
 Identities = 39/123 (31%), Positives = 59/123 (47%), Gaps = 1/123 (0%)
 Frame = +2

Query: 53  ALFAWGANSYGQLGLGHKEDVLLPQQLSEFCKPGCVKRITGGGGHSAIVTDQGSLFVCGL 232
           A+F WG N+ GQLGL  +E         +  +   V  I+ G  H+A++T  G +F  G 
Sbjct: 210 AVFGWGMNNAGQLGLSDEEGNRESPCHVKLLRTQKVVYISCGEEHTAVLTKSGGVFTFGA 269

Query: 233 NKDGQLGLGHTEDVLYFTLCKSLLGCPIQQVACGWDFTI-ILTKNGQVLSCGSNSFGQLG 409
              GQLG     D +       L+G  + Q+ACG   T+  +  +G + + G  + GQLG
Sbjct: 270 GSCGQLGHDSMNDEVNPRRVLELMGSEVTQIACGRQHTLAFVPSSGLIYAFGCGAKGQLG 329

Query: 410 VPH 418
             H
Sbjct: 330 TGH 332


>ref|XP_867304.1| PREDICTED: similar to hect domain and RLD 2 isoform 2 [Canis
            familiaris].
          Length = 2124

 Score =  124 bits (312), Expect = 1e-28
 Identities = 116/390 (29%), Positives = 171/390 (43%), Gaps = 10/390 (2%)
 Frame = +2

Query: 56   LFAWGANSYGQLG--LGHKEDVLLPQQLSEFCKPGCVKRITGGGGHSAIVTDQGSLFVCG 229
            ++ WG N  GQLG   G K  V  P +     +P    ++ GG      VT  G L+  G
Sbjct: 1244 IYGWGHNHRGQLGGIEGAKVKVPTPCEALATLRP---VQLIGGEQTLFAVTADGKLYATG 1300

Query: 230  LNKDGQLGLGHTEDVLYFTLCKSLLGCPIQQVAC--GWDFTIILTKNGQVLSCGSNSFGQ 403
                G+LG+G TE V   TL +S+    I++VA   G    + L+  G+V S G    G+
Sbjct: 1301 YGAGGRLGIGGTESVSTPTLLESIQHVFIKKVAVNSGGKHCLALSSEGEVYSWGEAEDGK 1360

Query: 404  LGVPHGPRR-CVVPQAIEVQRE-KVVSIXXXXXXXXXXXXSGLVFQWGTG-LASSGRRLC 574
            LG  HG R  C  P+ IE  R  +VV +            +G ++ WG G     G    
Sbjct: 1361 LG--HGNRSPCDRPRVIESLRGIEVVDVAAGGAHSACVTAAGDLYTWGKGRYGRLGHSDS 1418

Query: 575  PGQTLPLFLTAKEPSKVTGLENSQAVCVLAGSGHSASL--TDAGELYVWGSNKHGQLASQ 748
              Q         +P  V  L+  + V V  GSG + +L  TD   ++ WG   +G+L   
Sbjct: 1419 EDQL--------KPKLVEALQGHRVVDVACGSGDAQTLCLTDDDTVWSWGDGDYGKLGRG 1470

Query: 749  AAF-LPLPQKIEAHRFQNEKVAAVWSGWTHLVAQTETGKVFTWGRADYGQLGRTLESPEG 925
             +    +P KI++       V  V  G    VA T++G V+TWG+ DY +LG    S + 
Sbjct: 1471 GSDGCKVPMKIDS--LTGLGVVKVECGSQFSVALTKSGAVYTWGKGDYHRLGHG--SDDH 1526

Query: 926  WKPKKQASSLPCSRPARSVPSSLPCLTGATEVSCGSEHNLAVVGGTCYSWGWNEHGMCGD 1105
             +  +Q   L   +       SL C+       C +E       G  Y+WG N+ G  GD
Sbjct: 1527 VRRPRQVQGLQGKKVIAIATGSLHCV-------CCTED------GEVYTWGDNDEGQLGD 1573

Query: 1106 GTEANVWTPKPVQALRSSSGLRLGCGAGHS 1195
            GT   +  P+ V AL+     R+ CG+ H+
Sbjct: 1574 GTTNAIQRPRLVAALQGKKVNRVACGSAHT 1603



 Score =  119 bits (298), Expect = 6e-27
 Identities = 117/398 (29%), Positives = 167/398 (41%), Gaps = 16/398 (4%)
 Frame = +2

Query: 50   TALFAWGANSYGQLGLGHKEDVLLPQQLSEFCKPGCVKRITGGGGHSAIVTDQGSLFVCG 229
            T +F WG N   QLG G K   +     SE      V ++ GG      VT +G ++ CG
Sbjct: 247  TKVFVWGLNDKDQLG-GLKGSKIKVPSFSETLSALNVVQVAGGSKSLFAVTVEGKVYACG 305

Query: 230  LNKDGQLGLGHTEDVLYFTL-CKSLLGCPIQQVAC--GWDFTIILTKNGQVLSCGSNSFG 400
               +G+LGLG +   +       +L    +++VA   G      LT +G+V S G    G
Sbjct: 306  EATNGRLGLGLSSGTVPIPRQITALSSYVVKKVAVHSGGRHATALTVDGKVFSWGEGDDG 365

Query: 401  QLGVPHGPR-RCVVPQAIEVQREKVV-SIXXXXXXXXXXXXSGLVFQWGTGLASSGRRLC 574
            +LG  H  R  C  P+ IE  + K +  I            SG ++ WG G      RL 
Sbjct: 366  KLG--HFSRMNCDKPRLIEALKTKRIRDIACGSSHSAALTSSGELYTWGLGEYG---RLG 420

Query: 575  PGQTLPLFLTAKEPSKVTGLENSQAVCVLAGS--GHSASLTDAGELYVWGSNKHGQLASQ 748
             G       T  +P  V  L   + + V  GS    + +LTD G ++ WG    G+L   
Sbjct: 421  HGDNT----TQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFSWGDGDFGKLGRG 476

Query: 749  AAF-LPLPQKIEAHRFQNEKVAAVWSGWTHLVAQTETGKVFTWGRADYGQLG-------R 904
             +    +PQ IE  R   + V  +  G    +A T++G V+TWG+ DY +LG       R
Sbjct: 477  GSEGCNIPQNIE--RLNGQGVCQIECGAQFSLALTKSGVVWTWGKGDYFRLGHGSDVHVR 534

Query: 905  TLESPEGWKPKKQASSLPCSRPARSVPSSLPCLTGATEVSCGSEHNLAVV-GGTCYSWGW 1081
              +  EG + KK                          V+ G+ H LAV   G  Y+WG 
Sbjct: 535  KPQVVEGLRGKK-----------------------IVHVAVGALHCLAVTDAGQVYAWGD 571

Query: 1082 NEHGMCGDGTEANVWTPKPVQALRSSSGLRLGCGAGHS 1195
            N+HG  G+GT      P  VQ L      R+ CG+ HS
Sbjct: 572  NDHGQQGNGTTTVNRKPTLVQGLEGQKITRVACGSSHS 609



 Score =  114 bits (284), Expect = 3e-25
 Identities = 88/268 (32%), Positives = 126/268 (47%), Gaps = 3/268 (1%)
 Frame = +2

Query: 56   LFAWGANSYGQLGLGHKEDVLLPQQLSEFCKPGCVKRITGGGGHSAIVTDQGSLFVCGLN 235
            +F+WG    G+LG   + +   P+ L E  K   ++ I  G  HSA +T  G L+  GL 
Sbjct: 356  VFSWGEGDDGKLGHFSRMNCDKPR-LIEALKTKRIRDIACGSSHSAALTSSGELYTWGLG 414

Query: 236  KDGQLGLGHTEDVLYFTLCKSLLGCPIQQVACGWDF--TIILTKNGQVLSCGSNSFGQLG 409
            + G+LG G     L   + K LLG  + QVACG     T+ LT  G V S G   FG+LG
Sbjct: 415  EYGRLGHGDNTTQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFSWGDGDFGKLG 474

Query: 410  VPHGPRRCVVPQAIE-VQREKVVSIXXXXXXXXXXXXSGLVFQWGTGLASSGRRLCPGQT 586
               G   C +PQ IE +  + V  I            SG+V+ WG G      RL  G  
Sbjct: 475  -RGGSEGCNIPQNIERLNGQGVCQIECGAQFSLALTKSGVVWTWGKG---DYFRLGHGSD 530

Query: 587  LPLFLTAKEPSKVTGLENSQAVCVLAGSGHSASLTDAGELYVWGSNKHGQLASQAAFLPL 766
            + +    ++P  V GL   + V V  G+ H  ++TDAG++Y WG N HGQ  +    +  
Sbjct: 531  VHV----RKPQVVEGLRGKKIVHVAVGALHCLAVTDAGQVYAWGDNDHGQQGNGTTTVNR 586

Query: 767  PQKIEAHRFQNEKVAAVWSGWTHLVAQT 850
               +     + +K+  V  G +H VA T
Sbjct: 587  KPTL-VQGLEGQKITRVACGSSHSVAWT 613



 Score =  110 bits (274), Expect = 4e-24
 Identities = 91/348 (26%), Positives = 148/348 (42%), Gaps = 11/348 (3%)
 Frame = +2

Query: 182  GHSAIVTDQGSLFVCGLNKDGQLGLGHTEDVLYFTLCKSLLGCPIQQVACGWDFTIILTK 361
            G  +  T +  +FV GLN   QLG      +   +  ++L    + QVA G      +T 
Sbjct: 238  GLESAATIRTKVFVWGLNDKDQLGGLKGSKIKVPSFSETLSALNVVQVAGGSKSLFAVTV 297

Query: 362  NGQVLSCGSNSFGQLGVPHGPRRCVVPQAIEVQRE---KVVSIXXXXXXXXXXXXSGLVF 532
             G+V +CG  + G+LG+        +P+ I        K V++             G VF
Sbjct: 298  EGKVYACGEATNGRLGLGLSSGTVPIPRQITALSSYVVKKVAVHSGGRHATALTVDGKVF 357

Query: 533  QWGTG----LASSGRRLCPGQTLPLFLTAKEPSKVTGLENSQAVCVLAGSGHSASLTDAG 700
             WG G    L    R  C            +P  +  L+  +   +  GS HSA+LT +G
Sbjct: 358  SWGEGDDGKLGHFSRMNC-----------DKPRLIEALKTKRIRDIACGSSHSAALTSSG 406

Query: 701  ELYVWGSNKHGQLASQAAFLPL-PQKIEAHRFQNEKVAAVWSGWTHLVAQTETGKVFTWG 877
            ELY WG  ++G+L        L P+ ++          A  S     +A T+ G VF+WG
Sbjct: 407  ELYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFSWG 466

Query: 878  RADYGQLGRTLESPEGWKPKKQASSLPCSRPARSVPSSLPCLT--GATEVSCGSEHNLAV 1051
              D+G+LGR               S  C     ++P ++  L   G  ++ CG++ +LA+
Sbjct: 467  DGDFGKLGR-------------GGSEGC-----NIPQNIERLNGQGVCQIECGAQFSLAL 508

Query: 1052 V-GGTCYSWGWNEHGMCGDGTEANVWTPKPVQALRSSSGLRLGCGAGH 1192
               G  ++WG  ++   G G++ +V  P+ V+ LR    + +  GA H
Sbjct: 509  TKSGVVWTWGKGDYFRLGHGSDVHVRKPQVVEGLRGKKIVHVAVGALH 556



 Score =  102 bits (254), Expect = 8e-22
 Identities = 83/267 (31%), Positives = 122/267 (45%), Gaps = 4/267 (1%)
 Frame = +2

Query: 56   LFAWGANSYGQLGLGHKEDVLLPQQLSEFCKPGCVKRITGGGGHSAIVTDQGSLFVCGLN 235
            +++WG    G+LG G++     P+ + E  +   V  +  GG HSA VT  G L+  G  
Sbjct: 1350 VYSWGEAEDGKLGHGNRSPCDRPRVI-ESLRGIEVVDVAAGGAHSACVTAAGDLYTWGKG 1408

Query: 236  KDGQLGLGHTEDVLYFTLCKSLLGCPIQQVACGWD--FTIILTKNGQVLSCGSNSFGQLG 409
            + G+LG   +ED L   L ++L G  +  VACG     T+ LT +  V S G   +G+LG
Sbjct: 1409 RYGRLGHSDSEDQLKPKLVEALQGHRVVDVACGSGDAQTLCLTDDDTVWSWGDGDYGKLG 1468

Query: 410  VPHGPRRCVVPQAIE-VQREKVVSIXXXXXXXXXXXXSGLVFQWGTGLASSGRRLCPGQT 586
               G   C VP  I+ +    VV +            SG V+ WG G      RL  G  
Sbjct: 1469 -RGGSDGCKVPMKIDSLTGLGVVKVECGSQFSVALTKSGAVYTWGKG---DYHRLGHGSD 1524

Query: 587  LPLFLTAKEPSKVTGLENSQAVCVLAGSGHSASLTDAGELYVWGSNKHGQLASQAA-FLP 763
              +    + P +V GL+  + + +  GS H    T+ GE+Y WG N  GQL       + 
Sbjct: 1525 DHV----RRPRQVQGLQGKKVIAIATGSLHCVCCTEDGEVYTWGDNDEGQLGDGTTNAIQ 1580

Query: 764  LPQKIEAHRFQNEKVAAVWSGWTHLVA 844
             P+ + A   Q +KV  V  G  H +A
Sbjct: 1581 RPRLVAA--LQGKKVNRVACGSAHTLA 1605



 Score = 95.5 bits (236), Expect = 1e-19
 Identities = 92/343 (26%), Positives = 150/343 (43%), Gaps = 12/343 (3%)
 Frame = +2

Query: 56   LFAWGANSYGQLGLGHKEDVL-LPQQLSEFCKPGCVKRIT--GGGGHSAIVTDQGSLFVC 226
            ++A G  + G+LGLG     + +P+Q++       VK++    GG H+  +T  G +F  
Sbjct: 301  VYACGEATNGRLGLGLSSGTVPIPRQITALSSY-VVKKVAVHSGGRHATALTVDGKVFSW 359

Query: 227  GLNKDGQLGLGHTEDVLYFTLCKSLLGCPIQQVACGWDFTIILTKNGQVLSCGSNSFGQL 406
            G   DG+LG     +     L ++L    I+ +ACG   +  LT +G++ + G   +G+L
Sbjct: 360  GEGDDGKLGHFSRMNCDKPRLIEALKTKRIRDIACGSSHSAALTSSGELYTWGLGEYGRL 419

Query: 407  GVPHGPRRCVV-PQAIEV---QREKVVSIXXXXXXXXXXXXSGLVFQWGTG-LASSGRRL 571
            G  HG     + P+ ++V    R   V+              GLVF WG G     GR  
Sbjct: 420  G--HGDNTTQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFSWGDGDFGKLGRGG 477

Query: 572  CPGQTLPLFLTAKEPSKVTGLENSQAVCVL-AGSGHSASLTDAGELYVWGSNKHGQLASQ 748
              G  +P  +            N Q VC +  G+  S +LT +G ++ WG   + +L   
Sbjct: 478  SEGCNIPQNIERL---------NGQGVCQIECGAQFSLALTKSGVVWTWGKGDYFRLGHG 528

Query: 749  A-AFLPLPQKIEAHRFQNEKVAAVWSGWTHLVAQTETGKVFTWGRADYGQLGRTLESPEG 925
            +   +  PQ +E  R   +K+  V  G  H +A T+ G+V+ WG  D+GQ G    +   
Sbjct: 529  SDVHVRKPQVVEGLR--GKKIVHVAVGALHCLAVTDAGQVYAWGDNDHGQQGNGTTT--- 583

Query: 926  WKPKKQASSLPCSRPARSVPSSLPCLTGA--TEVSCGSEHNLA 1048
                               P+ +  L G   T V+CGS H++A
Sbjct: 584  ---------------VNRKPTLVQGLEGQKITRVACGSSHSVA 611



 Score = 79.3 bits (194), Expect = 7e-15
 Identities = 84/331 (25%), Positives = 136/331 (41%), Gaps = 46/331 (13%)
 Frame = +2

Query: 338  DFTIILTKNGQVLSCGSNSFGQLGVPHGPRRCVVPQAIEVQREKVVSIXXXXXXXXXXXX 517
            D+T+    +G +   G N  GQLG   G +  V      +   + V +            
Sbjct: 1233 DWTLSAGGSGTIYGWGHNHRGQLGGIEGAKVKVPTPCEALATLRPVQLIGGEQTLFAVTA 1292

Query: 518  SGLVFQWGTGLASSGRRLCPGQTLPLFLTAKEPSKVTGLENSQ-----AVCVLAGSGHSA 682
             G ++  G G   +G RL  G T       +  S  T LE+ Q      V V +G  H  
Sbjct: 1293 DGKLYATGYG---AGGRLGIGGT-------ESVSTPTLLESIQHVFIKKVAVNSGGKHCL 1342

Query: 683  SLTDAGELYVWGSNKHGQLA-SQAAFLPLPQKIEAHRFQNEKVAAVWSGWTHLVAQTETG 859
            +L+  GE+Y WG  + G+L     +    P+ IE+ R    +V  V +G  H    T  G
Sbjct: 1343 ALSSEGEVYSWGEAEDGKLGHGNRSPCDRPRVIESLR--GIEVVDVAAGGAHSACVTAAG 1400

Query: 860  KVFTWGRADYGQLGRTLESPEGWKPK-------KQASSLPC-SRPARS------------ 979
             ++TWG+  YG+LG + +S +  KPK        +   + C S  A++            
Sbjct: 1401 DLYTWGKGRYGRLGHS-DSEDQLKPKLVEALQGHRVVDVACGSGDAQTLCLTDDDTVWSW 1459

Query: 980  -----------------VPSSLPCLT--GATEVSCGSEHNLAVV-GGTCYSWGWNEHGMC 1099
                             VP  +  LT  G  +V CGS+ ++A+   G  Y+WG  ++   
Sbjct: 1460 GDGDYGKLGRGGSDGCKVPMKIDSLTGLGVVKVECGSQFSVALTKSGAVYTWGKGDYHRL 1519

Query: 1100 GDGTEANVWTPKPVQALRSSSGLRLGCGAGH 1192
            G G++ +V  P+ VQ L+    + +  G+ H
Sbjct: 1520 GHGSDDHVRRPRQVQGLQGKKVIAIATGSLH 1550



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 32/99 (32%), Positives = 49/99 (49%)
 Frame = +2

Query: 53   ALFAWGANSYGQLGLGHKEDVLLPQQLSEFCKPGCVKRITGGGGHSAIVTDQGSLFVCGL 232
            A++ WG   Y +LG G  + V  P+Q+ +  +   V  I  G  H    T+ G ++  G 
Sbjct: 1507 AVYTWGKGDYHRLGHGSDDHVRRPRQV-QGLQGKKVIAIATGSLHCVCCTEDGEVYTWGD 1565

Query: 233  NKDGQLGLGHTEDVLYFTLCKSLLGCPIQQVACGWDFTI 349
            N +GQLG G T  +    L  +L G  + +VACG   T+
Sbjct: 1566 NDEGQLGDGTTNAIQRPRLVAALQGKKVNRVACGSAHTL 1604


>ref|XP_536160.2| PREDICTED: similar to hect domain and RLD 2 isoform 1 [Canis
            familiaris].
          Length = 4837

 Score =  124 bits (312), Expect = 1e-28
 Identities = 116/390 (29%), Positives = 171/390 (43%), Gaps = 10/390 (2%)
 Frame = +2

Query: 56   LFAWGANSYGQLG--LGHKEDVLLPQQLSEFCKPGCVKRITGGGGHSAIVTDQGSLFVCG 229
            ++ WG N  GQLG   G K  V  P +     +P    ++ GG      VT  G L+  G
Sbjct: 3957 IYGWGHNHRGQLGGIEGAKVKVPTPCEALATLRP---VQLIGGEQTLFAVTADGKLYATG 4013

Query: 230  LNKDGQLGLGHTEDVLYFTLCKSLLGCPIQQVAC--GWDFTIILTKNGQVLSCGSNSFGQ 403
                G+LG+G TE V   TL +S+    I++VA   G    + L+  G+V S G    G+
Sbjct: 4014 YGAGGRLGIGGTESVSTPTLLESIQHVFIKKVAVNSGGKHCLALSSEGEVYSWGEAEDGK 4073

Query: 404  LGVPHGPRR-CVVPQAIEVQRE-KVVSIXXXXXXXXXXXXSGLVFQWGTG-LASSGRRLC 574
            LG  HG R  C  P+ IE  R  +VV +            +G ++ WG G     G    
Sbjct: 4074 LG--HGNRSPCDRPRVIESLRGIEVVDVAAGGAHSACVTAAGDLYTWGKGRYGRLGHSDS 4131

Query: 575  PGQTLPLFLTAKEPSKVTGLENSQAVCVLAGSGHSASL--TDAGELYVWGSNKHGQLASQ 748
              Q         +P  V  L+  + V V  GSG + +L  TD   ++ WG   +G+L   
Sbjct: 4132 EDQL--------KPKLVEALQGHRVVDVACGSGDAQTLCLTDDDTVWSWGDGDYGKLGRG 4183

Query: 749  AAF-LPLPQKIEAHRFQNEKVAAVWSGWTHLVAQTETGKVFTWGRADYGQLGRTLESPEG 925
             +    +P KI++       V  V  G    VA T++G V+TWG+ DY +LG    S + 
Sbjct: 4184 GSDGCKVPMKIDS--LTGLGVVKVECGSQFSVALTKSGAVYTWGKGDYHRLGHG--SDDH 4239

Query: 926  WKPKKQASSLPCSRPARSVPSSLPCLTGATEVSCGSEHNLAVVGGTCYSWGWNEHGMCGD 1105
             +  +Q   L   +       SL C+       C +E       G  Y+WG N+ G  GD
Sbjct: 4240 VRRPRQVQGLQGKKVIAIATGSLHCV-------CCTED------GEVYTWGDNDEGQLGD 4286

Query: 1106 GTEANVWTPKPVQALRSSSGLRLGCGAGHS 1195
            GT   +  P+ V AL+     R+ CG+ H+
Sbjct: 4287 GTTNAIQRPRLVAALQGKKVNRVACGSAHT 4316



 Score =  119 bits (298), Expect = 6e-27
 Identities = 117/398 (29%), Positives = 167/398 (41%), Gaps = 16/398 (4%)
 Frame = +2

Query: 50   TALFAWGANSYGQLGLGHKEDVLLPQQLSEFCKPGCVKRITGGGGHSAIVTDQGSLFVCG 229
            T +F WG N   QLG G K   +     SE      V ++ GG      VT +G ++ CG
Sbjct: 2960 TKVFVWGLNDKDQLG-GLKGSKIKVPSFSETLSALNVVQVAGGSKSLFAVTVEGKVYACG 3018

Query: 230  LNKDGQLGLGHTEDVLYFTL-CKSLLGCPIQQVAC--GWDFTIILTKNGQVLSCGSNSFG 400
               +G+LGLG +   +       +L    +++VA   G      LT +G+V S G    G
Sbjct: 3019 EATNGRLGLGLSSGTVPIPRQITALSSYVVKKVAVHSGGRHATALTVDGKVFSWGEGDDG 3078

Query: 401  QLGVPHGPR-RCVVPQAIEVQREKVV-SIXXXXXXXXXXXXSGLVFQWGTGLASSGRRLC 574
            +LG  H  R  C  P+ IE  + K +  I            SG ++ WG G      RL 
Sbjct: 3079 KLG--HFSRMNCDKPRLIEALKTKRIRDIACGSSHSAALTSSGELYTWGLGEYG---RLG 3133

Query: 575  PGQTLPLFLTAKEPSKVTGLENSQAVCVLAGS--GHSASLTDAGELYVWGSNKHGQLASQ 748
             G       T  +P  V  L   + + V  GS    + +LTD G ++ WG    G+L   
Sbjct: 3134 HGDNT----TQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFSWGDGDFGKLGRG 3189

Query: 749  AAF-LPLPQKIEAHRFQNEKVAAVWSGWTHLVAQTETGKVFTWGRADYGQLG-------R 904
             +    +PQ IE  R   + V  +  G    +A T++G V+TWG+ DY +LG       R
Sbjct: 3190 GSEGCNIPQNIE--RLNGQGVCQIECGAQFSLALTKSGVVWTWGKGDYFRLGHGSDVHVR 3247

Query: 905  TLESPEGWKPKKQASSLPCSRPARSVPSSLPCLTGATEVSCGSEHNLAVV-GGTCYSWGW 1081
              +  EG + KK                          V+ G+ H LAV   G  Y+WG 
Sbjct: 3248 KPQVVEGLRGKK-----------------------IVHVAVGALHCLAVTDAGQVYAWGD 3284

Query: 1082 NEHGMCGDGTEANVWTPKPVQALRSSSGLRLGCGAGHS 1195
            N+HG  G+GT      P  VQ L      R+ CG+ HS
Sbjct: 3285 NDHGQQGNGTTTVNRKPTLVQGLEGQKITRVACGSSHS 3322



 Score =  114 bits (284), Expect = 3e-25
 Identities = 88/268 (32%), Positives = 126/268 (47%), Gaps = 3/268 (1%)
 Frame = +2

Query: 56   LFAWGANSYGQLGLGHKEDVLLPQQLSEFCKPGCVKRITGGGGHSAIVTDQGSLFVCGLN 235
            +F+WG    G+LG   + +   P+ L E  K   ++ I  G  HSA +T  G L+  GL 
Sbjct: 3069 VFSWGEGDDGKLGHFSRMNCDKPR-LIEALKTKRIRDIACGSSHSAALTSSGELYTWGLG 3127

Query: 236  KDGQLGLGHTEDVLYFTLCKSLLGCPIQQVACGWDF--TIILTKNGQVLSCGSNSFGQLG 409
            + G+LG G     L   + K LLG  + QVACG     T+ LT  G V S G   FG+LG
Sbjct: 3128 EYGRLGHGDNTTQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFSWGDGDFGKLG 3187

Query: 410  VPHGPRRCVVPQAIE-VQREKVVSIXXXXXXXXXXXXSGLVFQWGTGLASSGRRLCPGQT 586
               G   C +PQ IE +  + V  I            SG+V+ WG G      RL  G  
Sbjct: 3188 -RGGSEGCNIPQNIERLNGQGVCQIECGAQFSLALTKSGVVWTWGKG---DYFRLGHGSD 3243

Query: 587  LPLFLTAKEPSKVTGLENSQAVCVLAGSGHSASLTDAGELYVWGSNKHGQLASQAAFLPL 766
            + +    ++P  V GL   + V V  G+ H  ++TDAG++Y WG N HGQ  +    +  
Sbjct: 3244 VHV----RKPQVVEGLRGKKIVHVAVGALHCLAVTDAGQVYAWGDNDHGQQGNGTTTVNR 3299

Query: 767  PQKIEAHRFQNEKVAAVWSGWTHLVAQT 850
               +     + +K+  V  G +H VA T
Sbjct: 3300 KPTL-VQGLEGQKITRVACGSSHSVAWT 3326



 Score =  110 bits (274), Expect = 4e-24
 Identities = 91/348 (26%), Positives = 148/348 (42%), Gaps = 11/348 (3%)
 Frame = +2

Query: 182  GHSAIVTDQGSLFVCGLNKDGQLGLGHTEDVLYFTLCKSLLGCPIQQVACGWDFTIILTK 361
            G  +  T +  +FV GLN   QLG      +   +  ++L    + QVA G      +T 
Sbjct: 2951 GLESAATIRTKVFVWGLNDKDQLGGLKGSKIKVPSFSETLSALNVVQVAGGSKSLFAVTV 3010

Query: 362  NGQVLSCGSNSFGQLGVPHGPRRCVVPQAIEVQRE---KVVSIXXXXXXXXXXXXSGLVF 532
             G+V +CG  + G+LG+        +P+ I        K V++             G VF
Sbjct: 3011 EGKVYACGEATNGRLGLGLSSGTVPIPRQITALSSYVVKKVAVHSGGRHATALTVDGKVF 3070

Query: 533  QWGTG----LASSGRRLCPGQTLPLFLTAKEPSKVTGLENSQAVCVLAGSGHSASLTDAG 700
             WG G    L    R  C            +P  +  L+  +   +  GS HSA+LT +G
Sbjct: 3071 SWGEGDDGKLGHFSRMNC-----------DKPRLIEALKTKRIRDIACGSSHSAALTSSG 3119

Query: 701  ELYVWGSNKHGQLASQAAFLPL-PQKIEAHRFQNEKVAAVWSGWTHLVAQTETGKVFTWG 877
            ELY WG  ++G+L        L P+ ++          A  S     +A T+ G VF+WG
Sbjct: 3120 ELYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFSWG 3179

Query: 878  RADYGQLGRTLESPEGWKPKKQASSLPCSRPARSVPSSLPCLT--GATEVSCGSEHNLAV 1051
              D+G+LGR               S  C     ++P ++  L   G  ++ CG++ +LA+
Sbjct: 3180 DGDFGKLGR-------------GGSEGC-----NIPQNIERLNGQGVCQIECGAQFSLAL 3221

Query: 1052 V-GGTCYSWGWNEHGMCGDGTEANVWTPKPVQALRSSSGLRLGCGAGH 1192
               G  ++WG  ++   G G++ +V  P+ V+ LR    + +  GA H
Sbjct: 3222 TKSGVVWTWGKGDYFRLGHGSDVHVRKPQVVEGLRGKKIVHVAVGALH 3269



 Score =  108 bits (270), Expect = 1e-23
 Identities = 90/326 (27%), Positives = 143/326 (43%), Gaps = 9/326 (2%)
 Frame = +2

Query: 242  GQLGLGHTEDVLYFTLCKSLLGCPIQQVACGWDFTIILTKNGQVLSCGSNSFGQLGVPHG 421
            G +G  +  +V+    C+ L    + Q+AC     +IL++NG+V +   NS         
Sbjct: 430  GLIGWKYYANVIGPIQCEGLANLGVTQIACAEKRFLILSRNGRVYTQAYNS--------- 480

Query: 422  PRRCVVPQAIE-VQREKVVSIXXXXXXXXXXXXS--GLVFQWGTGLASSGRRLCPGQTLP 592
                + PQ ++ +    +V I            +  G V+ WG G    G RL  G T+P
Sbjct: 481  --DTLAPQLVQGLASRNIVKIAAHSDGHHYLALAATGEVYSWGCG---DGGRLGHGDTVP 535

Query: 593  LFLTAKEPSKVTGLENSQA----VCVLAGSGHSASLTDAGELYVWGSNKHGQLA-SQAAF 757
            L    +EP  ++     QA    V +  GS +SA++T  GELY WG   +G+L    +  
Sbjct: 536  L----EEPKVISAFSGKQAGKHVVHIACGSTYSAAITAEGELYTWGRGNYGRLGHGSSED 591

Query: 758  LPLPQKIEAHRFQNEKVAAVWSGWTHLVAQTETGKVFTWGRADYGQLGRTLESPEGWKPK 937
              +P  +   +       A  SG    +A TE G+V++WG  DYG+LGR     +G K  
Sbjct: 592  EAIPMLVAGLKGLKVIDVACGSGDAQTLAVTENGQVWSWGDGDYGKLGR--GGSDGCKTP 649

Query: 938  KQASSLPCSRPARSVPSSLPCLTGATEVSCGSEHNLAVV-GGTCYSWGWNEHGMCGDGTE 1114
            K    L                    +V CGS+ ++A+   G  YSWG  ++   G GTE
Sbjct: 650  KLIEKLQD--------------LDVVKVRCGSQFSIALTKDGQVYSWGKGDNQRLGHGTE 695

Query: 1115 ANVWTPKPVQALRSSSGLRLGCGAGH 1192
             +V  PK ++ L+    + +  G+ H
Sbjct: 696  EHVRYPKLLEGLQGKKVIDVAAGSTH 721



 Score =  102 bits (254), Expect = 8e-22
 Identities = 83/267 (31%), Positives = 122/267 (45%), Gaps = 4/267 (1%)
 Frame = +2

Query: 56   LFAWGANSYGQLGLGHKEDVLLPQQLSEFCKPGCVKRITGGGGHSAIVTDQGSLFVCGLN 235
            +++WG    G+LG G++     P+ + E  +   V  +  GG HSA VT  G L+  G  
Sbjct: 4063 VYSWGEAEDGKLGHGNRSPCDRPRVI-ESLRGIEVVDVAAGGAHSACVTAAGDLYTWGKG 4121

Query: 236  KDGQLGLGHTEDVLYFTLCKSLLGCPIQQVACGWD--FTIILTKNGQVLSCGSNSFGQLG 409
            + G+LG   +ED L   L ++L G  +  VACG     T+ LT +  V S G   +G+LG
Sbjct: 4122 RYGRLGHSDSEDQLKPKLVEALQGHRVVDVACGSGDAQTLCLTDDDTVWSWGDGDYGKLG 4181

Query: 410  VPHGPRRCVVPQAIE-VQREKVVSIXXXXXXXXXXXXSGLVFQWGTGLASSGRRLCPGQT 586
               G   C VP  I+ +    VV +            SG V+ WG G      RL  G  
Sbjct: 4182 -RGGSDGCKVPMKIDSLTGLGVVKVECGSQFSVALTKSGAVYTWGKG---DYHRLGHGSD 4237

Query: 587  LPLFLTAKEPSKVTGLENSQAVCVLAGSGHSASLTDAGELYVWGSNKHGQLASQAA-FLP 763
              +    + P +V GL+  + + +  GS H    T+ GE+Y WG N  GQL       + 
Sbjct: 4238 DHV----RRPRQVQGLQGKKVIAIATGSLHCVCCTEDGEVYTWGDNDEGQLGDGTTNAIQ 4293

Query: 764  LPQKIEAHRFQNEKVAAVWSGWTHLVA 844
             P+ + A   Q +KV  V  G  H +A
Sbjct: 4294 RPRLVAA--LQGKKVNRVACGSAHTLA 4318



 Score = 97.8 bits (242), Expect = 2e-20
 Identities = 73/233 (31%), Positives = 108/233 (46%), Gaps = 6/233 (2%)
 Frame = +2

Query: 56   LFAWGANSYGQLGLGHKEDVLLPQQLSEFCKPGCVKRITG---GGGHSAIVTDQGSLFVC 226
            +++WG    G+LG G    +  P+ +S F      K +     G  +SA +T +G L+  
Sbjct: 517  VYSWGCGDGGRLGHGDTVPLEEPKVISAFSGKQAGKHVVHIACGSTYSAAITAEGELYTW 576

Query: 227  GLNKDGQLGLGHTEDVLYFTLCKSLLGCPIQQVACGWD--FTIILTKNGQVLSCGSNSFG 400
            G    G+LG G +ED     L   L G  +  VACG     T+ +T+NGQV S G   +G
Sbjct: 577  GRGNYGRLGHGSSEDEAIPMLVAGLKGLKVIDVACGSGDAQTLAVTENGQVWSWGDGDYG 636

Query: 401  QLGVPHGPRRCVVPQAIE-VQREKVVSIXXXXXXXXXXXXSGLVFQWGTGLASSGRRLCP 577
            +LG   G   C  P+ IE +Q   VV +             G V+ WG G     +RL  
Sbjct: 637  KLG-RGGSDGCKTPKLIEKLQDLDVVKVRCGSQFSIALTKDGQVYSWGKG---DNQRLGH 692

Query: 578  GQTLPLFLTAKEPSKVTGLENSQAVCVLAGSGHSASLTDAGELYVWGSNKHGQ 736
            G    +    + P  + GL+  + + V AGS H  +LT+  E++ WGSN   Q
Sbjct: 693  GTEEHV----RYPKLLEGLQGKKVIDVAAGSTHCLALTEDSEVHSWGSNDQCQ 741



 Score = 95.5 bits (236), Expect = 1e-19
 Identities = 92/343 (26%), Positives = 150/343 (43%), Gaps = 12/343 (3%)
 Frame = +2

Query: 56   LFAWGANSYGQLGLGHKEDVL-LPQQLSEFCKPGCVKRIT--GGGGHSAIVTDQGSLFVC 226
            ++A G  + G+LGLG     + +P+Q++       VK++    GG H+  +T  G +F  
Sbjct: 3014 VYACGEATNGRLGLGLSSGTVPIPRQITALSSY-VVKKVAVHSGGRHATALTVDGKVFSW 3072

Query: 227  GLNKDGQLGLGHTEDVLYFTLCKSLLGCPIQQVACGWDFTIILTKNGQVLSCGSNSFGQL 406
            G   DG+LG     +     L ++L    I+ +ACG   +  LT +G++ + G   +G+L
Sbjct: 3073 GEGDDGKLGHFSRMNCDKPRLIEALKTKRIRDIACGSSHSAALTSSGELYTWGLGEYGRL 3132

Query: 407  GVPHGPRRCVV-PQAIEV---QREKVVSIXXXXXXXXXXXXSGLVFQWGTG-LASSGRRL 571
            G  HG     + P+ ++V    R   V+              GLVF WG G     GR  
Sbjct: 3133 G--HGDNTTQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFSWGDGDFGKLGRGG 3190

Query: 572  CPGQTLPLFLTAKEPSKVTGLENSQAVCVL-AGSGHSASLTDAGELYVWGSNKHGQLASQ 748
              G  +P  +            N Q VC +  G+  S +LT +G ++ WG   + +L   
Sbjct: 3191 SEGCNIPQNIERL---------NGQGVCQIECGAQFSLALTKSGVVWTWGKGDYFRLGHG 3241

Query: 749  A-AFLPLPQKIEAHRFQNEKVAAVWSGWTHLVAQTETGKVFTWGRADYGQLGRTLESPEG 925
            +   +  PQ +E  R   +K+  V  G  H +A T+ G+V+ WG  D+GQ G    +   
Sbjct: 3242 SDVHVRKPQVVEGLR--GKKIVHVAVGALHCLAVTDAGQVYAWGDNDHGQQGNGTTT--- 3296

Query: 926  WKPKKQASSLPCSRPARSVPSSLPCLTGA--TEVSCGSEHNLA 1048
                               P+ +  L G   T V+CGS H++A
Sbjct: 3297 ---------------VNRKPTLVQGLEGQKITRVACGSSHSVA 3324



 Score = 79.3 bits (194), Expect = 7e-15
 Identities = 84/331 (25%), Positives = 136/331 (41%), Gaps = 46/331 (13%)
 Frame = +2

Query: 338  DFTIILTKNGQVLSCGSNSFGQLGVPHGPRRCVVPQAIEVQREKVVSIXXXXXXXXXXXX 517
            D+T+    +G +   G N  GQLG   G +  V      +   + V +            
Sbjct: 3946 DWTLSAGGSGTIYGWGHNHRGQLGGIEGAKVKVPTPCEALATLRPVQLIGGEQTLFAVTA 4005

Query: 518  SGLVFQWGTGLASSGRRLCPGQTLPLFLTAKEPSKVTGLENSQ-----AVCVLAGSGHSA 682
             G ++  G G   +G RL  G T       +  S  T LE+ Q      V V +G  H  
Sbjct: 4006 DGKLYATGYG---AGGRLGIGGT-------ESVSTPTLLESIQHVFIKKVAVNSGGKHCL 4055

Query: 683  SLTDAGELYVWGSNKHGQLA-SQAAFLPLPQKIEAHRFQNEKVAAVWSGWTHLVAQTETG 859
            +L+  GE+Y WG  + G+L     +    P+ IE+ R    +V  V +G  H    T  G
Sbjct: 4056 ALSSEGEVYSWGEAEDGKLGHGNRSPCDRPRVIESLR--GIEVVDVAAGGAHSACVTAAG 4113

Query: 860  KVFTWGRADYGQLGRTLESPEGWKPK-------KQASSLPC-SRPARS------------ 979
             ++TWG+  YG+LG + +S +  KPK        +   + C S  A++            
Sbjct: 4114 DLYTWGKGRYGRLGHS-DSEDQLKPKLVEALQGHRVVDVACGSGDAQTLCLTDDDTVWSW 4172

Query: 980  -----------------VPSSLPCLT--GATEVSCGSEHNLAVV-GGTCYSWGWNEHGMC 1099
                             VP  +  LT  G  +V CGS+ ++A+   G  Y+WG  ++   
Sbjct: 4173 GDGDYGKLGRGGSDGCKVPMKIDSLTGLGVVKVECGSQFSVALTKSGAVYTWGKGDYHRL 4232

Query: 1100 GDGTEANVWTPKPVQALRSSSGLRLGCGAGH 1192
            G G++ +V  P+ VQ L+    + +  G+ H
Sbjct: 4233 GHGSDDHVRRPRQVQGLQGKKVIAIATGSLH 4263



 Score = 78.2 bits (191), Expect = 2e-14
 Identities = 79/337 (23%), Positives = 130/337 (38%), Gaps = 9/337 (2%)
 Frame = +2

Query: 101  HKEDVLLPQQLSEFCKPGCVKRITGGGGHSAI-VTDQGSLFVCGLNKDGQLGLGHT---- 265
            +  D L PQ +        VK      GH  + +   G ++  G    G+LG G T    
Sbjct: 478  YNSDTLAPQLVQGLASRNIVKIAAHSDGHHYLALAATGEVYSWGCGDGGRLGHGDTVPLE 537

Query: 266  EDVLYFTLCKSLLGCPIQQVACGWDFTIILTKNGQVLSCGSNSFGQLGVPHGPRRCVVPQ 445
            E  +         G  +  +ACG  ++  +T  G++ + G  ++G+LG        +   
Sbjct: 538  EPKVISAFSGKQAGKHVVHIACGSTYSAAITAEGELYTWGRGNYGRLGHGSSEDEAIPML 597

Query: 446  AIEVQREKVVSIXXXXXXXXXXXXS--GLVFQWGTG-LASSGRRLCPGQTLPLFLTAKEP 616
               ++  KV+ +            +  G V+ WG G     GR    G         K P
Sbjct: 598  VAGLKGLKVIDVACGSGDAQTLAVTENGQVWSWGDGDYGKLGRGGSDG--------CKTP 649

Query: 617  SKVTGLENSQAVCVLAGSGHSASLTDAGELYVWGSNKHGQLA-SQAAFLPLPQKIEAHRF 793
              +  L++   V V  GS  S +LT  G++Y WG   + +L       +  P+ +E    
Sbjct: 650  KLIEKLQDLDVVKVRCGSQFSIALTKDGQVYSWGKGDNQRLGHGTEEHVRYPKLLEG--L 707

Query: 794  QNEKVAAVWSGWTHLVAQTETGKVFTWGRADYGQLGRTLESPEGWKPKKQASSLPCSRPA 973
            Q +KV  V +G TH +A TE  +V +WG  D  Q   TL                  R  
Sbjct: 708  QGKKVIDVAAGSTHCLALTEDSEVHSWGSNDQCQHFDTL------------------RVT 749

Query: 974  RSVPSSLPCLTGATEVSCGSEHNLAVVGGTCYSWGWN 1084
            +  P++LP L         ++H + +  G   S+ W+
Sbjct: 750  KPEPAALPGL--------DTKHIVGIACGPAQSFAWS 778



 Score = 72.4 bits (176), Expect = 9e-13
 Identities = 61/219 (27%), Positives = 95/219 (43%), Gaps = 3/219 (1%)
 Frame = +2

Query: 56   LFAWGANSYGQLGLGHKEDVLLPQQLSEFCKPGCVKRITGGGGHSAI-VTDQGSLFVCGL 232
            L+ WG  +YG+LG G  ED  +P  ++       +    G G    + VT+ G ++  G 
Sbjct: 573  LYTWGRGNYGRLGHGSSEDEAIPMLVAGLKGLKVIDVACGSGDAQTLAVTENGQVWSWGD 632

Query: 233  NKDGQLGLGHTEDVLYFTLCKSLLGCPIQQVACGWDFTIILTKNGQVLSCGSNSFGQLGV 412
               G+LG G ++      L + L    + +V CG  F+I LTK+GQV S G     +LG 
Sbjct: 633  GDYGKLGRGGSDGCKTPKLIEKLQDLDVVKVRCGSQFSIALTKDGQVYSWGKGDNQRLG- 691

Query: 413  PHGPRRCV-VPQAIE-VQREKVVSIXXXXXXXXXXXXSGLVFQWGTGLASSGRRLCPGQT 586
             HG    V  P+ +E +Q +KV+ +               V  WG     S  +     T
Sbjct: 692  -HGTEEHVRYPKLLEGLQGKKVIDVAAGSTHCLALTEDSEVHSWG-----SNDQCQHFDT 745

Query: 587  LPLFLTAKEPSKVTGLENSQAVCVLAGSGHSASLTDAGE 703
            L   +T  EP+ + GL+    V +  G   S + +   E
Sbjct: 746  LR--VTKPEPAALPGLDTKHIVGIACGPAQSFAWSSCSE 782



 Score = 70.5 bits (171), Expect = 3e-12
 Identities = 59/204 (28%), Positives = 89/204 (43%), Gaps = 10/204 (4%)
 Frame = +2

Query: 614  PSKVTGLENSQAVCVLAGSG--HSASLTDAGELYVWGSNKHGQLA-SQAAFLPLPQKIEA 784
            P  V GL +   V + A S   H  +L   GE+Y WG    G+L       L  P+ I A
Sbjct: 485  PQLVQGLASRNIVKIAAHSDGHHYLALAATGEVYSWGCGDGGRLGHGDTVPLEEPKVISA 544

Query: 785  H--RFQNEKVAAVWSGWTHLVAQTETGKVFTWGRADYGQLGRTLESPEGWKPKKQASSLP 958
               +   + V  +  G T+  A T  G+++TWGR +YG+LG      E            
Sbjct: 545  FSGKQAGKHVVHIACGSTYSAAITAEGELYTWGRGNYGRLGHGSSEDE------------ 592

Query: 959  CSRPARSVPSSLPCLTG--ATEVSCGS--EHNLAVV-GGTCYSWGWNEHGMCGDGTEANV 1123
                  ++P  +  L G    +V+CGS     LAV   G  +SWG  ++G  G G     
Sbjct: 593  ------AIPMLVAGLKGLKVIDVACGSGDAQTLAVTENGQVWSWGDGDYGKLGRGGSDGC 646

Query: 1124 WTPKPVQALRSSSGLRLGCGAGHS 1195
             TPK ++ L+    +++ CG+  S
Sbjct: 647  KTPKLIEKLQDLDVVKVRCGSQFS 670



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 32/99 (32%), Positives = 49/99 (49%)
 Frame = +2

Query: 53   ALFAWGANSYGQLGLGHKEDVLLPQQLSEFCKPGCVKRITGGGGHSAIVTDQGSLFVCGL 232
            A++ WG   Y +LG G  + V  P+Q+ +  +   V  I  G  H    T+ G ++  G 
Sbjct: 4220 AVYTWGKGDYHRLGHGSDDHVRRPRQV-QGLQGKKVIAIATGSLHCVCCTEDGEVYTWGD 4278

Query: 233  NKDGQLGLGHTEDVLYFTLCKSLLGCPIQQVACGWDFTI 349
            N +GQLG G T  +    L  +L G  + +VACG   T+
Sbjct: 4279 NDEGQLGDGTTNAIQRPRLVAALQGKKVNRVACGSAHTL 4317


>ref|XP_536367.2| PREDICTED: similar to hect domain and RLD 4 isoform b isoform 1
            [Canis familiaris].
          Length = 1049

 Score =  123 bits (308), Expect = 4e-28
 Identities = 111/372 (29%), Positives = 168/372 (45%), Gaps = 9/372 (2%)
 Frame = +2

Query: 56   LFAWGANSYGQLGLGH-KEDVLLPQQLSEFCKPGCVKRITGGGGHSAIVTDQGSLFVCGL 232
            +  WG  S+GQLGLG   E+++L  + S+F     V+ +  G  H+  V D G+++ CG 
Sbjct: 1    MLCWGNASFGQLGLGGIDEEIVLEPRKSDFFINKKVRDVGCGLRHTVFVLDDGTVYTCGC 60

Query: 233  NKDGQLGLGHTEDVLYFTLCKSLLGCPIQQVACGWDFTIILTKNGQVLSCGSNSFGQLGV 412
            N  GQ  LGH +         +L    I  V+CG   T+ L   GQV + G +S GQLG+
Sbjct: 61   NDLGQ--LGHEKSRKKPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGL 118

Query: 413  PHGPRRCV-VPQAIEVQRE-KVVSIXXXXXXXXXXXXSGLVFQWGTGLASSGRRLCPGQT 586
              G   C+ VP+ I+   + ++V +            +  VF WG               
Sbjct: 119  -LGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQ--------- 168

Query: 587  LPLFLTAKE---PSKVTGLENSQAVCVLAGSGHSASLTDAGELYVWGSNKHGQLA-SQAA 754
            L L +  K+   P  +  L     + V AG  HS  LT +G ++ WG NK GQL  +   
Sbjct: 169  LGLGIDCKKQASPQLIKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDEN 228

Query: 755  FLPLPQKIEAHRFQNEKVAAVWSGWTHLVAQTETGKVFTWGRADYGQLGRTLESPEGWKP 934
               +P  +++ R Q  K+  +  G  H  A T+ G VFT+G   YGQLG    S E   P
Sbjct: 229  DRYVPNLLKSLRTQ--KIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHE-INP 285

Query: 935  KKQASSLPCSRPARSVPSSLPCLTGATEVSCGSEHNLAVV--GGTCYSWGWNEHGMCGDG 1108
            +K    +                +  T+++CG +H  A V   G  YS+G   +G  G G
Sbjct: 286  RKVFELMG---------------SIVTQIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTG 330

Query: 1109 TEANVWTPKPVQ 1144
            + +N  +P  V+
Sbjct: 331  STSNRKSPFTVK 342



 Score = 87.8 bits (216), Expect = 2e-17
 Identities = 56/201 (27%), Positives = 97/201 (48%), Gaps = 5/201 (2%)
 Frame = +2

Query: 608  KEPSKVTGLENSQAVCVLAGSGHSASLTDAGELYVWGSNKHGQLA--SQAAFLPLPQKIE 781
            K+P +V  L+    V V  G  H+ +L D G++Y WG +  GQL        + +P+ I+
Sbjct: 73   KKPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGLLGSEECIRVPRNIK 132

Query: 782  AHRFQNEKVAAVWSGWTHLVAQTETGKVFTWGRADYGQLGRTLESPEGWKPKKQASSLPC 961
            +    + ++  V  G+ H +A ++  +VF WG+  YGQLG  ++       KKQAS    
Sbjct: 133  S--LSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGIDC------KKQAS---- 180

Query: 962  SRPARSVPSSLPCLTGA--TEVSCGSEHNLAV-VGGTCYSWGWNEHGMCGDGTEANVWTP 1132
                   P  +  L G    +V+ G  H+  + + G  + WG N+ G  G   E + + P
Sbjct: 181  -------PQLIKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVP 233

Query: 1133 KPVQALRSSSGLRLGCGAGHS 1195
              +++LR+   + + CG  H+
Sbjct: 234  NLLKSLRTQKIVYICCGEDHT 254



 Score = 65.1 bits (157), Expect = 1e-10
 Identities = 40/120 (33%), Positives = 58/120 (48%), Gaps = 1/120 (0%)
 Frame = +2

Query: 53  ALFAWGANSYGQLGLGHKEDVLLPQQLSEFCKPGCVKRITGGGGHSAIVTDQGSLFVCGL 232
           A+F WG N +GQLGL  + D  +P  L    +   +  I  G  H+A +T +G +F  G 
Sbjct: 210 AIFGWGRNKFGQLGLNDENDRYVPNLLKSL-RTQKIVYICCGEDHTAALTKEGGVFTFGA 268

Query: 233 NKDGQLGLGHTEDVLYFTLCKSLLGCPIQQVACGWDFT-IILTKNGQVLSCGSNSFGQLG 409
              GQLG   T   +       L+G  + Q+ACG   T   +  +G++ S G    GQLG
Sbjct: 269 GGYGQLGHNSTSHEINPRKVFELMGSIVTQIACGRQHTSAFVPSSGRIYSFGLGGNGQLG 328


>ref|XP_860046.1| PREDICTED: similar to hect domain and RLD 4 isoform b isoform 10
            [Canis familiaris].
          Length = 1055

 Score =  123 bits (308), Expect = 4e-28
 Identities = 111/372 (29%), Positives = 168/372 (45%), Gaps = 9/372 (2%)
 Frame = +2

Query: 56   LFAWGANSYGQLGLGH-KEDVLLPQQLSEFCKPGCVKRITGGGGHSAIVTDQGSLFVCGL 232
            +  WG  S+GQLGLG   E+++L  + S+F     V+ +  G  H+  V D G+++ CG 
Sbjct: 1    MLCWGNASFGQLGLGGIDEEIVLEPRKSDFFINKKVRDVGCGLRHTVFVLDDGTVYTCGC 60

Query: 233  NKDGQLGLGHTEDVLYFTLCKSLLGCPIQQVACGWDFTIILTKNGQVLSCGSNSFGQLGV 412
            N  GQ  LGH +         +L    I  V+CG   T+ L   GQV + G +S GQLG+
Sbjct: 61   NDLGQ--LGHEKSRKKPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGL 118

Query: 413  PHGPRRCV-VPQAIEVQRE-KVVSIXXXXXXXXXXXXSGLVFQWGTGLASSGRRLCPGQT 586
              G   C+ VP+ I+   + ++V +            +  VF WG               
Sbjct: 119  -LGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQ--------- 168

Query: 587  LPLFLTAKE---PSKVTGLENSQAVCVLAGSGHSASLTDAGELYVWGSNKHGQLA-SQAA 754
            L L +  K+   P  +  L     + V AG  HS  LT +G ++ WG NK GQL  +   
Sbjct: 169  LGLGIDCKKQASPQLIKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDEN 228

Query: 755  FLPLPQKIEAHRFQNEKVAAVWSGWTHLVAQTETGKVFTWGRADYGQLGRTLESPEGWKP 934
               +P  +++ R Q  K+  +  G  H  A T+ G VFT+G   YGQLG    S E   P
Sbjct: 229  DRYVPNLLKSLRTQ--KIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHE-INP 285

Query: 935  KKQASSLPCSRPARSVPSSLPCLTGATEVSCGSEHNLAVV--GGTCYSWGWNEHGMCGDG 1108
            +K    +                +  T+++CG +H  A V   G  YS+G   +G  G G
Sbjct: 286  RKVFELMG---------------SIVTQIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTG 330

Query: 1109 TEANVWTPKPVQ 1144
            + +N  +P  V+
Sbjct: 331  STSNRKSPFTVK 342



 Score = 87.8 bits (216), Expect = 2e-17
 Identities = 56/201 (27%), Positives = 97/201 (48%), Gaps = 5/201 (2%)
 Frame = +2

Query: 608  KEPSKVTGLENSQAVCVLAGSGHSASLTDAGELYVWGSNKHGQLA--SQAAFLPLPQKIE 781
            K+P +V  L+    V V  G  H+ +L D G++Y WG +  GQL        + +P+ I+
Sbjct: 73   KKPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGLLGSEECIRVPRNIK 132

Query: 782  AHRFQNEKVAAVWSGWTHLVAQTETGKVFTWGRADYGQLGRTLESPEGWKPKKQASSLPC 961
            +    + ++  V  G+ H +A ++  +VF WG+  YGQLG  ++       KKQAS    
Sbjct: 133  S--LSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGIDC------KKQAS---- 180

Query: 962  SRPARSVPSSLPCLTGA--TEVSCGSEHNLAV-VGGTCYSWGWNEHGMCGDGTEANVWTP 1132
                   P  +  L G    +V+ G  H+  + + G  + WG N+ G  G   E + + P
Sbjct: 181  -------PQLIKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVP 233

Query: 1133 KPVQALRSSSGLRLGCGAGHS 1195
              +++LR+   + + CG  H+
Sbjct: 234  NLLKSLRTQKIVYICCGEDHT 254



 Score = 65.1 bits (157), Expect = 1e-10
 Identities = 40/120 (33%), Positives = 58/120 (48%), Gaps = 1/120 (0%)
 Frame = +2

Query: 53  ALFAWGANSYGQLGLGHKEDVLLPQQLSEFCKPGCVKRITGGGGHSAIVTDQGSLFVCGL 232
           A+F WG N +GQLGL  + D  +P  L    +   +  I  G  H+A +T +G +F  G 
Sbjct: 210 AIFGWGRNKFGQLGLNDENDRYVPNLLKSL-RTQKIVYICCGEDHTAALTKEGGVFTFGA 268

Query: 233 NKDGQLGLGHTEDVLYFTLCKSLLGCPIQQVACGWDFT-IILTKNGQVLSCGSNSFGQLG 409
              GQLG   T   +       L+G  + Q+ACG   T   +  +G++ S G    GQLG
Sbjct: 269 GGYGQLGHNSTSHEINPRKVFELMGSIVTQIACGRQHTSAFVPSSGRIYSFGLGGNGQLG 328


>ref|XP_860006.1| PREDICTED: similar to hect domain and RLD 4 isoform a isoform 9
            [Canis familiaris].
          Length = 1054

 Score =  123 bits (308), Expect = 4e-28
 Identities = 111/372 (29%), Positives = 167/372 (44%), Gaps = 9/372 (2%)
 Frame = +2

Query: 56   LFAWGANSYGQLGLGH-KEDVLLPQQLSEFCKPGCVKRITGGGGHSAIVTDQGSLFVCGL 232
            +  WG  S+GQLGLG   E+++L  + S+F     V+ +  G  H+  V D G+++ CG 
Sbjct: 1    MLCWGNASFGQLGLGGIDEEIVLEPRKSDFFINKKVRDVGCGLRHTVFVLDDGTVYTCGC 60

Query: 233  NKDGQLGLGHTEDVLYFTLCKSLLGCPIQQVACGWDFTIILTKNGQVLSCGSNSFGQLGV 412
            N  GQ  LGH +         +L    I  V+CG   T+ L   GQV + G +S GQLG+
Sbjct: 61   NDLGQ--LGHEKSRKKPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGL 118

Query: 413  PHGPRRCV-VPQAIEVQRE-KVVSIXXXXXXXXXXXXSGLVFQWGTGLASSGRRLCPGQT 586
              G   C+ VP+ I+   + ++V +             G  F WG               
Sbjct: 119  -LGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKEGEFFCWGQNKYGQ--------- 168

Query: 587  LPLFLTAKE---PSKVTGLENSQAVCVLAGSGHSASLTDAGELYVWGSNKHGQLA-SQAA 754
            L L +  K+   P  +  L     + V AG  HS  LT +G ++ WG NK GQL  +   
Sbjct: 169  LGLGIDCKKQASPQLIKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDEN 228

Query: 755  FLPLPQKIEAHRFQNEKVAAVWSGWTHLVAQTETGKVFTWGRADYGQLGRTLESPEGWKP 934
               +P  +++ R Q  K+  +  G  H  A T+ G VFT+G   YGQLG    S E   P
Sbjct: 229  DRYVPNLLKSLRTQ--KIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHE-INP 285

Query: 935  KKQASSLPCSRPARSVPSSLPCLTGATEVSCGSEHNLAVV--GGTCYSWGWNEHGMCGDG 1108
            +K    +                +  T+++CG +H  A V   G  YS+G   +G  G G
Sbjct: 286  RKVFELMG---------------SIVTQIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTG 330

Query: 1109 TEANVWTPKPVQ 1144
            + +N  +P  V+
Sbjct: 331  STSNRKSPFTVK 342



 Score = 87.8 bits (216), Expect = 2e-17
 Identities = 56/201 (27%), Positives = 97/201 (48%), Gaps = 5/201 (2%)
 Frame = +2

Query: 608  KEPSKVTGLENSQAVCVLAGSGHSASLTDAGELYVWGSNKHGQLA--SQAAFLPLPQKIE 781
            K+P +V  L+    V V  G  H+ +L D G++Y WG +  GQL        + +P+ I+
Sbjct: 73   KKPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGLLGSEECIRVPRNIK 132

Query: 782  AHRFQNEKVAAVWSGWTHLVAQTETGKVFTWGRADYGQLGRTLESPEGWKPKKQASSLPC 961
            +    + ++  V  G+ H +A ++ G+ F WG+  YGQLG  ++       KKQAS    
Sbjct: 133  S--LSDIQIVQVACGYYHSLALSKEGEFFCWGQNKYGQLGLGIDC------KKQAS---- 180

Query: 962  SRPARSVPSSLPCLTGA--TEVSCGSEHNLAV-VGGTCYSWGWNEHGMCGDGTEANVWTP 1132
                   P  +  L G    +V+ G  H+  + + G  + WG N+ G  G   E + + P
Sbjct: 181  -------PQLIKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVP 233

Query: 1133 KPVQALRSSSGLRLGCGAGHS 1195
              +++LR+   + + CG  H+
Sbjct: 234  NLLKSLRTQKIVYICCGEDHT 254



 Score = 65.1 bits (157), Expect = 1e-10
 Identities = 40/120 (33%), Positives = 58/120 (48%), Gaps = 1/120 (0%)
 Frame = +2

Query: 53  ALFAWGANSYGQLGLGHKEDVLLPQQLSEFCKPGCVKRITGGGGHSAIVTDQGSLFVCGL 232
           A+F WG N +GQLGL  + D  +P  L    +   +  I  G  H+A +T +G +F  G 
Sbjct: 210 AIFGWGRNKFGQLGLNDENDRYVPNLLKSL-RTQKIVYICCGEDHTAALTKEGGVFTFGA 268

Query: 233 NKDGQLGLGHTEDVLYFTLCKSLLGCPIQQVACGWDFT-IILTKNGQVLSCGSNSFGQLG 409
              GQLG   T   +       L+G  + Q+ACG   T   +  +G++ S G    GQLG
Sbjct: 269 GGYGQLGHNSTSHEINPRKVFELMGSIVTQIACGRQHTSAFVPSSGRIYSFGLGGNGQLG 328


>ref|XP_859968.1| PREDICTED: similar to hect domain and RLD 4 isoform b isoform 8
            [Canis familiaris].
          Length = 1049

 Score =  123 bits (308), Expect = 4e-28
 Identities = 111/372 (29%), Positives = 168/372 (45%), Gaps = 9/372 (2%)
 Frame = +2

Query: 56   LFAWGANSYGQLGLGH-KEDVLLPQQLSEFCKPGCVKRITGGGGHSAIVTDQGSLFVCGL 232
            +  WG  S+GQLGLG   E+++L  + S+F     V+ +  G  H+  V D G+++ CG 
Sbjct: 1    MLCWGNASFGQLGLGGIDEEIVLEPRKSDFFINKKVRDVGCGLRHTVFVLDDGTVYTCGC 60

Query: 233  NKDGQLGLGHTEDVLYFTLCKSLLGCPIQQVACGWDFTIILTKNGQVLSCGSNSFGQLGV 412
            N  GQ  LGH +         +L    I  V+CG   T+ L   GQV + G +S GQLG+
Sbjct: 61   NDLGQ--LGHEKSRKKPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGL 118

Query: 413  PHGPRRCV-VPQAIEVQRE-KVVSIXXXXXXXXXXXXSGLVFQWGTGLASSGRRLCPGQT 586
              G   C+ VP+ I+   + ++V +            +  VF WG               
Sbjct: 119  -LGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQ--------- 168

Query: 587  LPLFLTAKE---PSKVTGLENSQAVCVLAGSGHSASLTDAGELYVWGSNKHGQLA-SQAA 754
            L L +  K+   P  +  L     + V AG  HS  LT +G ++ WG NK GQL  +   
Sbjct: 169  LGLGIDCKKQASPQLIKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDEN 228

Query: 755  FLPLPQKIEAHRFQNEKVAAVWSGWTHLVAQTETGKVFTWGRADYGQLGRTLESPEGWKP 934
               +P  +++ R Q  K+  +  G  H  A T+ G VFT+G   YGQLG    S E   P
Sbjct: 229  DRYVPNLLKSLRTQ--KIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHE-INP 285

Query: 935  KKQASSLPCSRPARSVPSSLPCLTGATEVSCGSEHNLAVV--GGTCYSWGWNEHGMCGDG 1108
            +K    +                +  T+++CG +H  A V   G  YS+G   +G  G G
Sbjct: 286  RKVFELMG---------------SIVTQIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTG 330

Query: 1109 TEANVWTPKPVQ 1144
            + +N  +P  V+
Sbjct: 331  STSNRKSPFTVK 342



 Score = 87.8 bits (216), Expect = 2e-17
 Identities = 56/201 (27%), Positives = 97/201 (48%), Gaps = 5/201 (2%)
 Frame = +2

Query: 608  KEPSKVTGLENSQAVCVLAGSGHSASLTDAGELYVWGSNKHGQLA--SQAAFLPLPQKIE 781
            K+P +V  L+    V V  G  H+ +L D G++Y WG +  GQL        + +P+ I+
Sbjct: 73   KKPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGLLGSEECIRVPRNIK 132

Query: 782  AHRFQNEKVAAVWSGWTHLVAQTETGKVFTWGRADYGQLGRTLESPEGWKPKKQASSLPC 961
            +    + ++  V  G+ H +A ++  +VF WG+  YGQLG  ++       KKQAS    
Sbjct: 133  S--LSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGIDC------KKQAS---- 180

Query: 962  SRPARSVPSSLPCLTGA--TEVSCGSEHNLAV-VGGTCYSWGWNEHGMCGDGTEANVWTP 1132
                   P  +  L G    +V+ G  H+  + + G  + WG N+ G  G   E + + P
Sbjct: 181  -------PQLIKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVP 233

Query: 1133 KPVQALRSSSGLRLGCGAGHS 1195
              +++LR+   + + CG  H+
Sbjct: 234  NLLKSLRTQKIVYICCGEDHT 254



 Score = 65.1 bits (157), Expect = 1e-10
 Identities = 40/120 (33%), Positives = 58/120 (48%), Gaps = 1/120 (0%)
 Frame = +2

Query: 53  ALFAWGANSYGQLGLGHKEDVLLPQQLSEFCKPGCVKRITGGGGHSAIVTDQGSLFVCGL 232
           A+F WG N +GQLGL  + D  +P  L    +   +  I  G  H+A +T +G +F  G 
Sbjct: 210 AIFGWGRNKFGQLGLNDENDRYVPNLLKSL-RTQKIVYICCGEDHTAALTKEGGVFTFGA 268

Query: 233 NKDGQLGLGHTEDVLYFTLCKSLLGCPIQQVACGWDFT-IILTKNGQVLSCGSNSFGQLG 409
              GQLG   T   +       L+G  + Q+ACG   T   +  +G++ S G    GQLG
Sbjct: 269 GGYGQLGHNSTSHEINPRKVFELMGSIVTQIACGRQHTSAFVPSSGRIYSFGLGGNGQLG 328


>ref|XP_859933.1| PREDICTED: similar to hect domain and RLD 4 isoform b isoform 7
            [Canis familiaris].
          Length = 1020

 Score =  123 bits (308), Expect = 4e-28
 Identities = 111/372 (29%), Positives = 168/372 (45%), Gaps = 9/372 (2%)
 Frame = +2

Query: 56   LFAWGANSYGQLGLGH-KEDVLLPQQLSEFCKPGCVKRITGGGGHSAIVTDQGSLFVCGL 232
            +  WG  S+GQLGLG   E+++L  + S+F     V+ +  G  H+  V D G+++ CG 
Sbjct: 1    MLCWGNASFGQLGLGGIDEEIVLEPRKSDFFINKKVRDVGCGLRHTVFVLDDGTVYTCGC 60

Query: 233  NKDGQLGLGHTEDVLYFTLCKSLLGCPIQQVACGWDFTIILTKNGQVLSCGSNSFGQLGV 412
            N  GQ  LGH +         +L    I  V+CG   T+ L   GQV + G +S GQLG+
Sbjct: 61   NDLGQ--LGHEKSRKKPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGL 118

Query: 413  PHGPRRCV-VPQAIEVQRE-KVVSIXXXXXXXXXXXXSGLVFQWGTGLASSGRRLCPGQT 586
              G   C+ VP+ I+   + ++V +            +  VF WG               
Sbjct: 119  -LGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQ--------- 168

Query: 587  LPLFLTAKE---PSKVTGLENSQAVCVLAGSGHSASLTDAGELYVWGSNKHGQLA-SQAA 754
            L L +  K+   P  +  L     + V AG  HS  LT +G ++ WG NK GQL  +   
Sbjct: 169  LGLGIDCKKQASPQLIKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDEN 228

Query: 755  FLPLPQKIEAHRFQNEKVAAVWSGWTHLVAQTETGKVFTWGRADYGQLGRTLESPEGWKP 934
               +P  +++ R Q  K+  +  G  H  A T+ G VFT+G   YGQLG    S E   P
Sbjct: 229  DRYVPNLLKSLRTQ--KIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHE-INP 285

Query: 935  KKQASSLPCSRPARSVPSSLPCLTGATEVSCGSEHNLAVV--GGTCYSWGWNEHGMCGDG 1108
            +K    +                +  T+++CG +H  A V   G  YS+G   +G  G G
Sbjct: 286  RKVFELMG---------------SIVTQIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTG 330

Query: 1109 TEANVWTPKPVQ 1144
            + +N  +P  V+
Sbjct: 331  STSNRKSPFTVK 342



 Score = 87.8 bits (216), Expect = 2e-17
 Identities = 56/201 (27%), Positives = 97/201 (48%), Gaps = 5/201 (2%)
 Frame = +2

Query: 608  KEPSKVTGLENSQAVCVLAGSGHSASLTDAGELYVWGSNKHGQLA--SQAAFLPLPQKIE 781
            K+P +V  L+    V V  G  H+ +L D G++Y WG +  GQL        + +P+ I+
Sbjct: 73   KKPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGLLGSEECIRVPRNIK 132

Query: 782  AHRFQNEKVAAVWSGWTHLVAQTETGKVFTWGRADYGQLGRTLESPEGWKPKKQASSLPC 961
            +    + ++  V  G+ H +A ++  +VF WG+  YGQLG  ++       KKQAS    
Sbjct: 133  S--LSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGIDC------KKQAS---- 180

Query: 962  SRPARSVPSSLPCLTGA--TEVSCGSEHNLAV-VGGTCYSWGWNEHGMCGDGTEANVWTP 1132
                   P  +  L G    +V+ G  H+  + + G  + WG N+ G  G   E + + P
Sbjct: 181  -------PQLIKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVP 233

Query: 1133 KPVQALRSSSGLRLGCGAGHS 1195
              +++LR+   + + CG  H+
Sbjct: 234  NLLKSLRTQKIVYICCGEDHT 254



 Score = 65.1 bits (157), Expect = 1e-10
 Identities = 40/120 (33%), Positives = 58/120 (48%), Gaps = 1/120 (0%)
 Frame = +2

Query: 53  ALFAWGANSYGQLGLGHKEDVLLPQQLSEFCKPGCVKRITGGGGHSAIVTDQGSLFVCGL 232
           A+F WG N +GQLGL  + D  +P  L    +   +  I  G  H+A +T +G +F  G 
Sbjct: 210 AIFGWGRNKFGQLGLNDENDRYVPNLLKSL-RTQKIVYICCGEDHTAALTKEGGVFTFGA 268

Query: 233 NKDGQLGLGHTEDVLYFTLCKSLLGCPIQQVACGWDFT-IILTKNGQVLSCGSNSFGQLG 409
              GQLG   T   +       L+G  + Q+ACG   T   +  +G++ S G    GQLG
Sbjct: 269 GGYGQLGHNSTSHEINPRKVFELMGSIVTQIACGRQHTSAFVPSSGRIYSFGLGGNGQLG 328


>ref|XP_859900.1| PREDICTED: similar to hect domain and RLD 4 isoform a isoform 6
            [Canis familiaris].
          Length = 979

 Score =  123 bits (308), Expect = 4e-28
 Identities = 111/372 (29%), Positives = 168/372 (45%), Gaps = 9/372 (2%)
 Frame = +2

Query: 56   LFAWGANSYGQLGLGH-KEDVLLPQQLSEFCKPGCVKRITGGGGHSAIVTDQGSLFVCGL 232
            +  WG  S+GQLGLG   E+++L  + S+F     V+ +  G  H+  V D G+++ CG 
Sbjct: 1    MLCWGNASFGQLGLGGIDEEIVLEPRKSDFFINKKVRDVGCGLRHTVFVLDDGTVYTCGC 60

Query: 233  NKDGQLGLGHTEDVLYFTLCKSLLGCPIQQVACGWDFTIILTKNGQVLSCGSNSFGQLGV 412
            N  GQ  LGH +         +L    I  V+CG   T+ L   GQV + G +S GQLG+
Sbjct: 61   NDLGQ--LGHEKSRKKPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGL 118

Query: 413  PHGPRRCV-VPQAIEVQRE-KVVSIXXXXXXXXXXXXSGLVFQWGTGLASSGRRLCPGQT 586
              G   C+ VP+ I+   + ++V +            +  VF WG               
Sbjct: 119  -LGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQ--------- 168

Query: 587  LPLFLTAKE---PSKVTGLENSQAVCVLAGSGHSASLTDAGELYVWGSNKHGQLA-SQAA 754
            L L +  K+   P  +  L     + V AG  HS  LT +G ++ WG NK GQL  +   
Sbjct: 169  LGLGIDCKKQASPQLIKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDEN 228

Query: 755  FLPLPQKIEAHRFQNEKVAAVWSGWTHLVAQTETGKVFTWGRADYGQLGRTLESPEGWKP 934
               +P  +++ R Q  K+  +  G  H  A T+ G VFT+G   YGQLG    S E   P
Sbjct: 229  DRYVPNLLKSLRTQ--KIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHE-INP 285

Query: 935  KKQASSLPCSRPARSVPSSLPCLTGATEVSCGSEHNLAVV--GGTCYSWGWNEHGMCGDG 1108
            +K    +                +  T+++CG +H  A V   G  YS+G   +G  G G
Sbjct: 286  RKVFELMG---------------SIVTQIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTG 330

Query: 1109 TEANVWTPKPVQ 1144
            + +N  +P  V+
Sbjct: 331  STSNRKSPFTVK 342



 Score = 87.8 bits (216), Expect = 2e-17
 Identities = 56/201 (27%), Positives = 97/201 (48%), Gaps = 5/201 (2%)
 Frame = +2

Query: 608  KEPSKVTGLENSQAVCVLAGSGHSASLTDAGELYVWGSNKHGQLA--SQAAFLPLPQKIE 781
            K+P +V  L+    V V  G  H+ +L D G++Y WG +  GQL        + +P+ I+
Sbjct: 73   KKPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGLLGSEECIRVPRNIK 132

Query: 782  AHRFQNEKVAAVWSGWTHLVAQTETGKVFTWGRADYGQLGRTLESPEGWKPKKQASSLPC 961
            +    + ++  V  G+ H +A ++  +VF WG+  YGQLG  ++       KKQAS    
Sbjct: 133  S--LSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGIDC------KKQAS---- 180

Query: 962  SRPARSVPSSLPCLTGA--TEVSCGSEHNLAV-VGGTCYSWGWNEHGMCGDGTEANVWTP 1132
                   P  +  L G    +V+ G  H+  + + G  + WG N+ G  G   E + + P
Sbjct: 181  -------PQLIKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVP 233

Query: 1133 KPVQALRSSSGLRLGCGAGHS 1195
              +++LR+   + + CG  H+
Sbjct: 234  NLLKSLRTQKIVYICCGEDHT 254



 Score = 65.1 bits (157), Expect = 1e-10
 Identities = 40/120 (33%), Positives = 58/120 (48%), Gaps = 1/120 (0%)
 Frame = +2

Query: 53  ALFAWGANSYGQLGLGHKEDVLLPQQLSEFCKPGCVKRITGGGGHSAIVTDQGSLFVCGL 232
           A+F WG N +GQLGL  + D  +P  L    +   +  I  G  H+A +T +G +F  G 
Sbjct: 210 AIFGWGRNKFGQLGLNDENDRYVPNLLKSL-RTQKIVYICCGEDHTAALTKEGGVFTFGA 268

Query: 233 NKDGQLGLGHTEDVLYFTLCKSLLGCPIQQVACGWDFT-IILTKNGQVLSCGSNSFGQLG 409
              GQLG   T   +       L+G  + Q+ACG   T   +  +G++ S G    GQLG
Sbjct: 269 GGYGQLGHNSTSHEINPRKVFELMGSIVTQIACGRQHTSAFVPSSGRIYSFGLGGNGQLG 328


>ref|XP_859830.1| PREDICTED: similar to hect domain and RLD 4 isoform b isoform 4
            [Canis familiaris].
          Length = 488

 Score =  123 bits (308), Expect = 4e-28
 Identities = 111/372 (29%), Positives = 168/372 (45%), Gaps = 9/372 (2%)
 Frame = +2

Query: 56   LFAWGANSYGQLGLGH-KEDVLLPQQLSEFCKPGCVKRITGGGGHSAIVTDQGSLFVCGL 232
            +  WG  S+GQLGLG   E+++L  + S+F     V+ +  G  H+  V D G+++ CG 
Sbjct: 1    MLCWGNASFGQLGLGGIDEEIVLEPRKSDFFINKKVRDVGCGLRHTVFVLDDGTVYTCGC 60

Query: 233  NKDGQLGLGHTEDVLYFTLCKSLLGCPIQQVACGWDFTIILTKNGQVLSCGSNSFGQLGV 412
            N  GQ  LGH +         +L    I  V+CG   T+ L   GQV + G +S GQLG+
Sbjct: 61   NDLGQ--LGHEKSRKKPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGL 118

Query: 413  PHGPRRCV-VPQAIEVQRE-KVVSIXXXXXXXXXXXXSGLVFQWGTGLASSGRRLCPGQT 586
              G   C+ VP+ I+   + ++V +            +  VF WG               
Sbjct: 119  -LGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQ--------- 168

Query: 587  LPLFLTAKE---PSKVTGLENSQAVCVLAGSGHSASLTDAGELYVWGSNKHGQLA-SQAA 754
            L L +  K+   P  +  L     + V AG  HS  LT +G ++ WG NK GQL  +   
Sbjct: 169  LGLGIDCKKQASPQLIKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDEN 228

Query: 755  FLPLPQKIEAHRFQNEKVAAVWSGWTHLVAQTETGKVFTWGRADYGQLGRTLESPEGWKP 934
               +P  +++ R Q  K+  +  G  H  A T+ G VFT+G   YGQLG    S E   P
Sbjct: 229  DRYVPNLLKSLRTQ--KIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHE-INP 285

Query: 935  KKQASSLPCSRPARSVPSSLPCLTGATEVSCGSEHNLAVV--GGTCYSWGWNEHGMCGDG 1108
            +K    +                +  T+++CG +H  A V   G  YS+G   +G  G G
Sbjct: 286  RKVFELMG---------------SIVTQIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTG 330

Query: 1109 TEANVWTPKPVQ 1144
            + +N  +P  V+
Sbjct: 331  STSNRKSPFTVK 342



 Score = 87.8 bits (216), Expect = 2e-17
 Identities = 56/201 (27%), Positives = 97/201 (48%), Gaps = 5/201 (2%)
 Frame = +2

Query: 608  KEPSKVTGLENSQAVCVLAGSGHSASLTDAGELYVWGSNKHGQLA--SQAAFLPLPQKIE 781
            K+P +V  L+    V V  G  H+ +L D G++Y WG +  GQL        + +P+ I+
Sbjct: 73   KKPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGLLGSEECIRVPRNIK 132

Query: 782  AHRFQNEKVAAVWSGWTHLVAQTETGKVFTWGRADYGQLGRTLESPEGWKPKKQASSLPC 961
            +    + ++  V  G+ H +A ++  +VF WG+  YGQLG  ++       KKQAS    
Sbjct: 133  S--LSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGIDC------KKQAS---- 180

Query: 962  SRPARSVPSSLPCLTGA--TEVSCGSEHNLAV-VGGTCYSWGWNEHGMCGDGTEANVWTP 1132
                   P  +  L G    +V+ G  H+  + + G  + WG N+ G  G   E + + P
Sbjct: 181  -------PQLIKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVP 233

Query: 1133 KPVQALRSSSGLRLGCGAGHS 1195
              +++LR+   + + CG  H+
Sbjct: 234  NLLKSLRTQKIVYICCGEDHT 254



 Score = 65.1 bits (157), Expect = 1e-10
 Identities = 40/120 (33%), Positives = 58/120 (48%), Gaps = 1/120 (0%)
 Frame = +2

Query: 53  ALFAWGANSYGQLGLGHKEDVLLPQQLSEFCKPGCVKRITGGGGHSAIVTDQGSLFVCGL 232
           A+F WG N +GQLGL  + D  +P  L    +   +  I  G  H+A +T +G +F  G 
Sbjct: 210 AIFGWGRNKFGQLGLNDENDRYVPNLLKSL-RTQKIVYICCGEDHTAALTKEGGVFTFGA 268

Query: 233 NKDGQLGLGHTEDVLYFTLCKSLLGCPIQQVACGWDFT-IILTKNGQVLSCGSNSFGQLG 409
              GQLG   T   +       L+G  + Q+ACG   T   +  +G++ S G    GQLG
Sbjct: 269 GGYGQLGHNSTSHEINPRKVFELMGSIVTQIACGRQHTSAFVPSSGRIYSFGLGGNGQLG 328


  Database: RefSeq49_CP.fasta
    Posted date:  Oct 17, 2011  1:42 PM
  Number of letters in database: 18,874,504
  Number of sequences in database:  33,336
  
Lambda     K      H
   0.318    0.134    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 33336
Number of Hits to DB: 59,228,505
Number of extensions: 1873084
Number of successful extensions: 8104
Number of sequences better than 1.0e-05: 29
Number of HSP's gapped: 7574
Number of HSP's successfully gapped: 133
Length of query: 421
Length of database: 18,874,504
Length adjustment: 105
Effective length of query: 316
Effective length of database: 15,374,224
Effective search space: 4858254784
Effective search space used: 4858254784
Neighboring words threshold: 12
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 35 (18.1 bits)

BLASTX 2.2.24 [Aug-08-2010]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= 20110601C-004015
         (1263 letters)

Database: RefSeq49_HP.fasta 
           32,964 sequences; 18,297,164 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

Alignment   gi|NP_036271.1| secretion-regulating guanine nucleotide exchang...   677   0.0  
Alignment   gi|NP_055421.1| probable E3 ubiquitin-protein ligase HERC3 [Hom...   134   2e-31
Alignment   gi|NP_056416.2| probable E3 ubiquitin-protein ligase HERC4 isof...   127   2e-29
Alignment   gi|NP_071362.1| probable E3 ubiquitin-protein ligase HERC4 isof...   127   2e-29
Alignment   gi|NP_004658.3| E3 ubiquitin-protein ligase HERC2 [Homo sapiens].    124   2e-28
Alignment   gi|NP_060661.3| RCC1 and BTB domain-containing protein 1 [Homo ...   103   3e-22
Alignment   gi|NP_001259.1| RCC1 and BTB domain-containing protein 2 [Homo ...   102   6e-22
Alignment   gi|NP_000319.1| X-linked retinitis pigmentosa GTPase regulator ...    99   8e-21
Alignment   gi|NP_001030025.1| X-linked retinitis pigmentosa GTPase regulat...    99   8e-21
Alignment   gi|NP_003913.3| probable E3 ubiquitin-protein ligase HERC1 [Hom...    98   2e-20

>ref|NP_036271.1| secretion-regulating guanine nucleotide exchange factor [Homo
            sapiens].
          Length = 458

 Score =  677 bits (1747), Expect = 0.0
 Identities = 320/399 (80%), Positives = 346/399 (86%)
 Frame = +2

Query: 53   ALFAWGANSYGQLGLGHKEDVLLPQQLSEFCKPGCVKRITGGGGHSAIVTDQGSLFVCGL 232
            ALFAWGANSYGQLGLGHKEDVLLPQQL++FCKP  V+RITGGGGHSA+VTD G LFVCGL
Sbjct: 16   ALFAWGANSYGQLGLGHKEDVLLPQQLNDFCKPRSVRRITGGGGHSAVVTDGGDLFVCGL 75

Query: 233  NKDGQLGLGHTEDVLYFTLCKSLLGCPIQQVACGWDFTIILTKNGQVLSCGSNSFGQLGV 412
            NKDGQLGLGHTED+ YFT CKSL GCPIQQVACGWDFTI+LT+NGQVLSCGSNSFGQLGV
Sbjct: 76   NKDGQLGLGHTEDIPYFTPCKSLFGCPIQQVACGWDFTIMLTENGQVLSCGSNSFGQLGV 135

Query: 413  PHGPRRCVVPQAIEVQREKVVSIXXXXXXXXXXXXSGLVFQWGTGLASSGRRLCPGQTLP 592
            PHGPRRCVVPQAIE+ +EKVV I            SG+VFQWGTGLAS GRRLCPGQTLP
Sbjct: 136  PHGPRRCVVPQAIELHKEKVVCIAAGLRHAVAATASGIVFQWGTGLASCGRRLCPGQTLP 195

Query: 593  LFLTAKEPSKVTGLENSQAVCVLAGSGHSASLTDAGELYVWGSNKHGQLASQAAFLPLPQ 772
            LF TAKEPS+VTGLENS+A+CVLAGS HSASLTDAGE+YVWGSNKHGQLA++AAFLP+PQ
Sbjct: 196  LFFTAKEPSRVTGLENSKAMCVLAGSDHSASLTDAGEVYVWGSNKHGQLANEAAFLPVPQ 255

Query: 773  KIEAHRFQNEKVAAVWSGWTHLVAQTETGKVFTWGRADYGQLGRTLESPEGWKPKKQASS 952
            KIEAH FQNEKV A+WSGWTHLVAQTETGK+FTWGRADYGQLGR LE+ EGWK +KQ S 
Sbjct: 256  KIEAHCFQNEKVTAIWSGWTHLVAQTETGKMFTWGRADYGQLGRKLETYEGWKLEKQDSF 315

Query: 953  LPCSRPARSVPSSLPCLTGATEVSCGSEHNLAVVGGTCYSWGWNEHGMCGDGTEANVWTP 1132
            LPCSRP  S+PSS  CLTGATEVSCGSEHNLA++GG CYSWGWNEHGMCGDGTEANVW P
Sbjct: 316  LPCSRPPNSMPSSPHCLTGATEVSCGSEHNLAIIGGVCYSWGWNEHGMCGDGTEANVWAP 375

Query: 1133 KPVQALRSSSGLRLGCGAGHSXXXXXXXXXXXXGQRPRV 1249
            KPVQAL SSSGL +GCGAGHS             Q P+V
Sbjct: 376  KPVQALLSSSGLLVGCGAGHSLALCQLPAHPALVQDPKV 414


>ref|NP_055421.1| probable E3 ubiquitin-protein ligase HERC3 [Homo sapiens].
          Length = 1050

 Score =  134 bits (336), Expect = 2e-31
 Identities = 106/368 (28%), Positives = 162/368 (44%), Gaps = 5/368 (1%)
 Frame = +2

Query: 56   LFAWGANSYGQLGLG-HKEDVLLPQQLSEFCKPGCVKRITGGGGHSAIVTDQGSLFVCGL 232
            +  WG  S GQ G+  + + ++   Q+  F     VK +  GG HS  + + G ++ CGL
Sbjct: 1    MLCWGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGNHSVFLLEDGEVYTCGL 60

Query: 233  NKDGQLGLGHTEDVLYFTLCKSLLGCPIQQVACGWDFTIILTKNGQVLSCGSNSFGQLGV 412
            N  GQ  LGH  +        +L    I  VACG   ++ L+  GQ+ S G+ S GQLG+
Sbjct: 61   NTKGQ--LGHEREGNKPEQIGALADQHIIHVACGESHSLALSDRGQLFSWGAGSDGQLGL 118

Query: 413  PHGPRRCVVPQAIE-VQREKVVSIXXXXXXXXXXXXSGLVFQWGTGLASSGRRLCPGQTL 589
                    VP+ I+ + ++ ++ +             G  F WG    +S  +L  G+  
Sbjct: 119  MTTEDSVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWG---KNSHGQLGLGKEF 175

Query: 590  PLFLTAKEPSKVTGLENSQAVCVLAGSGHSASLTDAGELYVWGSNKHGQLA-SQAAFLPL 766
            P   +   P +V  LE      V AG  HS +L+ +G ++ WG N  GQL  S       
Sbjct: 176  P---SQASPQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEKDRES 232

Query: 767  PQKIEAHRFQNEKVAAVWSGWTHLVAQTETGKVFTWGRADYGQLGRTLESPEGWKPKKQA 946
            P  ++  R Q  KV  +  G  H    T++G VFT+G    GQLG    + E   P++  
Sbjct: 233  PCHVKLLRTQ--KVVYISCGEEHTAVLTKSGGVFTFGAGSCGQLGHDSMNDE-VNPRRVL 289

Query: 947  SSLPCSRPARSVPSSLPCLTGATEVSCGSEHNLAVV--GGTCYSWGWNEHGMCGDGTEAN 1120
              +                +  T+++CG +H LA V   G  Y++G    G  G G   N
Sbjct: 290  ELMG---------------SEVTQIACGRQHTLAFVPSSGLIYAFGCGARGQLGTGHTCN 334

Query: 1121 VWTPKPVQ 1144
            V  P PV+
Sbjct: 335  VKCPSPVK 342



 Score = 92.8 bits (229), Expect = 6e-19
 Identities = 76/307 (24%), Positives = 124/307 (40%), Gaps = 4/307 (1%)
 Frame = +2

Query: 287  LCKSLLGCPIQQVACGWDFTIILTKNGQVLSCGSNSFGQLGVPHGPRRCVVPQAIEVQRE 466
            +C  +    +++VACG + ++ L ++G+V +CG N+ GQLG  H        Q   +  +
Sbjct: 27   VCGFISDRSVKEVACGGNHSVFLLEDGEVYTCGLNTKGQLG--HEREGNKPEQIGALADQ 84

Query: 467  KVVSIXXXXXXXXXXXXSGLVFQWGTGLASSGRRLCPGQTLPLFLTAKE---PSKVTGLE 637
             ++ +             G +F WG G  S G+       L L  T      P  +  L 
Sbjct: 85   HIIHVACGESHSLALSDRGQLFSWGAG--SDGQ-------LGLMTTEDSVAVPRLIQKLN 135

Query: 638  NSQAVCVLAGSGHSASLTDAGELYVWGSNKHGQLASQAAFLPLPQKIEAHRFQNEKVAAV 817
                + V  G+ H  +L   G+ + WG N HGQL     F            +   +A V
Sbjct: 136  QQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQV 195

Query: 818  WSGWTHLVAQTETGKVFTWGRADYGQLGRTLESPEGWKPKKQASSLPCSRPARSVPSSLP 997
             +G  H  A + +G VF WG  + GQLG + E     K ++    +   R  + V     
Sbjct: 196  AAGGAHSFALSLSGAVFGWGMNNAGQLGLSDE-----KDRESPCHVKLLRTQKVV----- 245

Query: 998  CLTGATEVSCGSEHNLAVV-GGTCYSWGWNEHGMCGDGTEANVWTPKPVQALRSSSGLRL 1174
                   +SCG EH   +   G  +++G    G  G  +  +   P+ V  L  S   ++
Sbjct: 246  ------YISCGEEHTAVLTKSGGVFTFGAGSCGQLGHDSMNDEVNPRRVLELMGSEVTQI 299

Query: 1175 GCGAGHS 1195
             CG  H+
Sbjct: 300  ACGRQHT 306



 Score = 65.1 bits (157), Expect = 1e-10
 Identities = 40/123 (32%), Positives = 62/123 (50%), Gaps = 1/123 (0%)
 Frame = +2

Query: 53  ALFAWGANSYGQLGLGHKEDVLLPQQLSEFCKPGCVKRITGGGGHSAIVTDQGSLFVCGL 232
           A+F WG N+ GQLGL  ++D   P  + +  +   V  I+ G  H+A++T  G +F  G 
Sbjct: 210 AVFGWGMNNAGQLGLSDEKDRESPCHV-KLLRTQKVVYISCGEEHTAVLTKSGGVFTFGA 268

Query: 233 NKDGQLGLGHTEDVLYFTLCKSLLGCPIQQVACGWDFTI-ILTKNGQVLSCGSNSFGQLG 409
              GQLG     D +       L+G  + Q+ACG   T+  +  +G + + G  + GQLG
Sbjct: 269 GSCGQLGHDSMNDEVNPRRVLELMGSEVTQIACGRQHTLAFVPSSGLIYAFGCGARGQLG 328

Query: 410 VPH 418
             H
Sbjct: 329 TGH 331


>ref|NP_056416.2| probable E3 ubiquitin-protein ligase HERC4 isoform b [Homo sapiens].
          Length = 1049

 Score =  127 bits (319), Expect = 2e-29
 Identities = 116/375 (30%), Positives = 172/375 (45%), Gaps = 12/375 (3%)
 Frame = +2

Query: 56   LFAWGANSYGQLGLGH-KEDVLLPQQLSEFCKPGCVKRITGGGGHSAIVTDQGSLFVCGL 232
            +  WG  S+GQLGLG   E+++L  + S+F     V+ +  G  H+  V D G+++ CG 
Sbjct: 1    MLCWGNASFGQLGLGGIDEEIVLEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGC 60

Query: 233  NKDGQLGLGHTEDVLYFTLCKSLLGCPIQQVACGWDFTIILTKNGQVLSCGSNSFGQLGV 412
            N  GQLG  H +         +L    I  V+CG   T+ L   GQV + G +S GQLG+
Sbjct: 61   NDLGQLG--HEKSRKKPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGL 118

Query: 413  PHGPRRCV-VPQAIEVQRE-KVVSIXXXXXXXXXXXXSGLVFQWGT------GLASSGRR 568
              G   C+ VP+ I+   + ++V +            +  VF WG       GL +    
Sbjct: 119  V-GSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTD--- 174

Query: 569  LCPGQTLPLFLTAKEPSKVTGLENSQAVCVLAGSGHSASLTDAGELYVWGSNKHGQLA-S 745
             C  QT P  L +     + G+   Q   V AG  HS  LT +G ++ WG NK GQL  +
Sbjct: 175  -CKKQTSPQLLKS-----LLGIPFMQ---VAAGGAHSFVLTLSGAIFGWGRNKFGQLGLN 225

Query: 746  QAAFLPLPQKIEAHRFQNEKVAAVWSGWTHLVAQTETGKVFTWGRADYGQLGRTLESPEG 925
                  +P  +++ R Q  K+  +  G  H  A T+ G VFT+G   YGQLG    S E 
Sbjct: 226  DENDRYVPNLLKSLRSQ--KIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHE- 282

Query: 926  WKPKKQASSLPCSRPARSVPSSLPCLTGATEVSCGSEHNLAVV--GGTCYSWGWNEHGMC 1099
              P+K    +                +  TE++CG +H  A V   G  YS+G   +G  
Sbjct: 283  INPRKVFELMG---------------SIVTEIACGRQHTSAFVPSSGRIYSFGLGGNGQL 327

Query: 1100 GDGTEANVWTPKPVQ 1144
            G G+ +N  +P  V+
Sbjct: 328  GTGSTSNRKSPFTVK 342



 Score = 87.8 bits (216), Expect = 2e-17
 Identities = 58/201 (28%), Positives = 95/201 (47%), Gaps = 5/201 (2%)
 Frame = +2

Query: 608  KEPSKVTGLENSQAVCVLAGSGHSASLTDAGELYVWGSNKHGQ--LASQAAFLPLPQKIE 781
            K+P +V  L+    V V  G  H+ +L D G++Y WG +  GQ  L      + +P+ I+
Sbjct: 73   KKPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGLVGSEECIRVPRNIK 132

Query: 782  AHRFQNEKVAAVWSGWTHLVAQTETGKVFTWGRADYGQLGRTLESPEGWKPKKQASSLPC 961
            +    + ++  V  G+ H +A ++  +VF WG+  YGQLG       G   KKQ S    
Sbjct: 133  S--LSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGL------GTDCKKQTS---- 180

Query: 962  SRPARSVPSSLPCLTGA--TEVSCGSEHNLAV-VGGTCYSWGWNEHGMCGDGTEANVWTP 1132
                   P  L  L G    +V+ G  H+  + + G  + WG N+ G  G   E + + P
Sbjct: 181  -------PQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVP 233

Query: 1133 KPVQALRSSSGLRLGCGAGHS 1195
              +++LRS   + + CG  H+
Sbjct: 234  NLLKSLRSQKIVYICCGEDHT 254



 Score = 63.9 bits (154), Expect = 3e-10
 Identities = 39/120 (32%), Positives = 58/120 (48%), Gaps = 1/120 (0%)
 Frame = +2

Query: 53  ALFAWGANSYGQLGLGHKEDVLLPQQLSEFCKPGCVKRITGGGGHSAIVTDQGSLFVCGL 232
           A+F WG N +GQLGL  + D  +P  L    +   +  I  G  H+A +T +G +F  G 
Sbjct: 210 AIFGWGRNKFGQLGLNDENDRYVPNLLKSL-RSQKIVYICCGEDHTAALTKEGGVFTFGA 268

Query: 233 NKDGQLGLGHTEDVLYFTLCKSLLGCPIQQVACGWDFT-IILTKNGQVLSCGSNSFGQLG 409
              GQLG   T   +       L+G  + ++ACG   T   +  +G++ S G    GQLG
Sbjct: 269 GGYGQLGHNSTSHEINPRKVFELMGSIVTEIACGRQHTSAFVPSSGRIYSFGLGGNGQLG 328


>ref|NP_071362.1| probable E3 ubiquitin-protein ligase HERC4 isoform a [Homo sapiens].
          Length = 1057

 Score =  127 bits (319), Expect = 2e-29
 Identities = 116/375 (30%), Positives = 172/375 (45%), Gaps = 12/375 (3%)
 Frame = +2

Query: 56   LFAWGANSYGQLGLGH-KEDVLLPQQLSEFCKPGCVKRITGGGGHSAIVTDQGSLFVCGL 232
            +  WG  S+GQLGLG   E+++L  + S+F     V+ +  G  H+  V D G+++ CG 
Sbjct: 1    MLCWGNASFGQLGLGGIDEEIVLEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGC 60

Query: 233  NKDGQLGLGHTEDVLYFTLCKSLLGCPIQQVACGWDFTIILTKNGQVLSCGSNSFGQLGV 412
            N  GQLG  H +         +L    I  V+CG   T+ L   GQV + G +S GQLG+
Sbjct: 61   NDLGQLG--HEKSRKKPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGL 118

Query: 413  PHGPRRCV-VPQAIEVQRE-KVVSIXXXXXXXXXXXXSGLVFQWGT------GLASSGRR 568
              G   C+ VP+ I+   + ++V +            +  VF WG       GL +    
Sbjct: 119  V-GSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTD--- 174

Query: 569  LCPGQTLPLFLTAKEPSKVTGLENSQAVCVLAGSGHSASLTDAGELYVWGSNKHGQLA-S 745
             C  QT P  L +     + G+   Q   V AG  HS  LT +G ++ WG NK GQL  +
Sbjct: 175  -CKKQTSPQLLKS-----LLGIPFMQ---VAAGGAHSFVLTLSGAIFGWGRNKFGQLGLN 225

Query: 746  QAAFLPLPQKIEAHRFQNEKVAAVWSGWTHLVAQTETGKVFTWGRADYGQLGRTLESPEG 925
                  +P  +++ R Q  K+  +  G  H  A T+ G VFT+G   YGQLG    S E 
Sbjct: 226  DENDRYVPNLLKSLRSQ--KIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHE- 282

Query: 926  WKPKKQASSLPCSRPARSVPSSLPCLTGATEVSCGSEHNLAVV--GGTCYSWGWNEHGMC 1099
              P+K    +                +  TE++CG +H  A V   G  YS+G   +G  
Sbjct: 283  INPRKVFELMG---------------SIVTEIACGRQHTSAFVPSSGRIYSFGLGGNGQL 327

Query: 1100 GDGTEANVWTPKPVQ 1144
            G G+ +N  +P  V+
Sbjct: 328  GTGSTSNRKSPFTVK 342



 Score = 87.8 bits (216), Expect = 2e-17
 Identities = 58/201 (28%), Positives = 95/201 (47%), Gaps = 5/201 (2%)
 Frame = +2

Query: 608  KEPSKVTGLENSQAVCVLAGSGHSASLTDAGELYVWGSNKHGQ--LASQAAFLPLPQKIE 781
            K+P +V  L+    V V  G  H+ +L D G++Y WG +  GQ  L      + +P+ I+
Sbjct: 73   KKPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGLVGSEECIRVPRNIK 132

Query: 782  AHRFQNEKVAAVWSGWTHLVAQTETGKVFTWGRADYGQLGRTLESPEGWKPKKQASSLPC 961
            +    + ++  V  G+ H +A ++  +VF WG+  YGQLG       G   KKQ S    
Sbjct: 133  S--LSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGL------GTDCKKQTS---- 180

Query: 962  SRPARSVPSSLPCLTGA--TEVSCGSEHNLAV-VGGTCYSWGWNEHGMCGDGTEANVWTP 1132
                   P  L  L G    +V+ G  H+  + + G  + WG N+ G  G   E + + P
Sbjct: 181  -------PQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVP 233

Query: 1133 KPVQALRSSSGLRLGCGAGHS 1195
              +++LRS   + + CG  H+
Sbjct: 234  NLLKSLRSQKIVYICCGEDHT 254



 Score = 63.9 bits (154), Expect = 3e-10
 Identities = 39/120 (32%), Positives = 58/120 (48%), Gaps = 1/120 (0%)
 Frame = +2

Query: 53  ALFAWGANSYGQLGLGHKEDVLLPQQLSEFCKPGCVKRITGGGGHSAIVTDQGSLFVCGL 232
           A+F WG N +GQLGL  + D  +P  L    +   +  I  G  H+A +T +G +F  G 
Sbjct: 210 AIFGWGRNKFGQLGLNDENDRYVPNLLKSL-RSQKIVYICCGEDHTAALTKEGGVFTFGA 268

Query: 233 NKDGQLGLGHTEDVLYFTLCKSLLGCPIQQVACGWDFT-IILTKNGQVLSCGSNSFGQLG 409
              GQLG   T   +       L+G  + ++ACG   T   +  +G++ S G    GQLG
Sbjct: 269 GGYGQLGHNSTSHEINPRKVFELMGSIVTEIACGRQHTSAFVPSSGRIYSFGLGGNGQLG 328


>ref|NP_004658.3| E3 ubiquitin-protein ligase HERC2 [Homo sapiens].
          Length = 4834

 Score =  124 bits (311), Expect = 2e-28
 Identities = 115/390 (29%), Positives = 171/390 (43%), Gaps = 10/390 (2%)
 Frame = +2

Query: 56   LFAWGANSYGQLG--LGHKEDVLLPQQLSEFCKPGCVKRITGGGGHSAIVTDQGSLFVCG 229
            ++ WG N  GQLG   G K  V  P +     +P    ++ GG      VT  G L+  G
Sbjct: 3954 IYGWGHNHRGQLGGIEGAKVKVPTPCEALATLRP---VQLIGGEQTLFAVTADGKLYATG 4010

Query: 230  LNKDGQLGLGHTEDVLYFTLCKSLLGCPIQQVAC--GWDFTIILTKNGQVLSCGSNSFGQ 403
                G+LG+G TE V   TL +S+    I++VA   G    + L+  G+V S G    G+
Sbjct: 4011 YGAGGRLGIGGTESVSTPTLLESIQHVFIKKVAVNSGGKHCLALSSEGEVYSWGEAEDGK 4070

Query: 404  LGVPHGPRR-CVVPQAIEVQRE-KVVSIXXXXXXXXXXXXSGLVFQWGTG-LASSGRRLC 574
            LG  HG R  C  P+ IE  R  +VV +            +G ++ WG G     G    
Sbjct: 4071 LG--HGNRSPCDRPRVIESLRGIEVVDVAAGGAHSACVTAAGDLYTWGKGRYGRLGHSDS 4128

Query: 575  PGQTLPLFLTAKEPSKVTGLENSQAVCVLAGSGHSASL--TDAGELYVWGSNKHGQLASQ 748
              Q         +P  V  L+  + V +  GSG + +L  TD   ++ WG   +G+L   
Sbjct: 4129 EDQL--------KPKLVEALQGHRVVDIACGSGDAQTLCLTDDDTVWSWGDGDYGKLGRG 4180

Query: 749  AAF-LPLPQKIEAHRFQNEKVAAVWSGWTHLVAQTETGKVFTWGRADYGQLGRTLESPEG 925
             +    +P KI++       V  V  G    VA T++G V+TWG+ DY +LG    S + 
Sbjct: 4181 GSDGCKVPMKIDS--LTGLGVVKVECGSQFSVALTKSGAVYTWGKGDYHRLGHG--SDDH 4236

Query: 926  WKPKKQASSLPCSRPARSVPSSLPCLTGATEVSCGSEHNLAVVGGTCYSWGWNEHGMCGD 1105
             +  +Q   L   +       SL C+       C +E       G  Y+WG N+ G  GD
Sbjct: 4237 VRRPRQVQGLQGKKVIAIATGSLHCV-------CCTED------GEVYTWGDNDEGQLGD 4283

Query: 1106 GTEANVWTPKPVQALRSSSGLRLGCGAGHS 1195
            GT   +  P+ V AL+     R+ CG+ H+
Sbjct: 4284 GTTNAIQRPRLVAALQGKKVNRVACGSAHT 4313



 Score =  119 bits (298), Expect = 6e-27
 Identities = 117/398 (29%), Positives = 167/398 (41%), Gaps = 16/398 (4%)
 Frame = +2

Query: 50   TALFAWGANSYGQLGLGHKEDVLLPQQLSEFCKPGCVKRITGGGGHSAIVTDQGSLFVCG 229
            T +F WG N   QLG G K   +     SE      V ++ GG      VT +G ++ CG
Sbjct: 2959 TKVFVWGLNDKDQLG-GLKGSKIKVPSFSETLSALNVVQVAGGSKSLFAVTVEGKVYACG 3017

Query: 230  LNKDGQLGLGHTEDVLYFTL-CKSLLGCPIQQVAC--GWDFTIILTKNGQVLSCGSNSFG 400
               +G+LGLG +   +       +L    +++VA   G      LT +G+V S G    G
Sbjct: 3018 EATNGRLGLGISSGTVPIPRQITALSSYVVKKVAVHSGGRHATALTVDGKVFSWGEGDDG 3077

Query: 401  QLGVPHGPR-RCVVPQAIEVQREKVV-SIXXXXXXXXXXXXSGLVFQWGTGLASSGRRLC 574
            +LG  H  R  C  P+ IE  + K +  I            SG ++ WG G      RL 
Sbjct: 3078 KLG--HFSRMNCDKPRLIEALKTKRIRDIACGSSHSAALTSSGELYTWGLGEYG---RLG 3132

Query: 575  PGQTLPLFLTAKEPSKVTGLENSQAVCVLAGS--GHSASLTDAGELYVWGSNKHGQLASQ 748
             G       T  +P  V  L   + + V  GS    + +LTD G ++ WG    G+L   
Sbjct: 3133 HGDNT----TQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFSWGDGDFGKLGRG 3188

Query: 749  AAF-LPLPQKIEAHRFQNEKVAAVWSGWTHLVAQTETGKVFTWGRADYGQLG-------R 904
             +    +PQ IE  R   + V  +  G    +A T++G V+TWG+ DY +LG       R
Sbjct: 3189 GSEGCNIPQNIE--RLNGQGVCQIECGAQFSLALTKSGVVWTWGKGDYFRLGHGSDVHVR 3246

Query: 905  TLESPEGWKPKKQASSLPCSRPARSVPSSLPCLTGATEVSCGSEHNLAVV-GGTCYSWGW 1081
              +  EG + KK                          V+ G+ H LAV   G  Y+WG 
Sbjct: 3247 KPQVVEGLRGKK-----------------------IVHVAVGALHCLAVTDSGQVYAWGD 3283

Query: 1082 NEHGMCGDGTEANVWTPKPVQALRSSSGLRLGCGAGHS 1195
            N+HG  G+GT      P  VQ L      R+ CG+ HS
Sbjct: 3284 NDHGQQGNGTTTVNRKPTLVQGLEGQKITRVACGSSHS 3321



 Score =  112 bits (281), Expect = 6e-25
 Identities = 87/268 (32%), Positives = 126/268 (47%), Gaps = 3/268 (1%)
 Frame = +2

Query: 56   LFAWGANSYGQLGLGHKEDVLLPQQLSEFCKPGCVKRITGGGGHSAIVTDQGSLFVCGLN 235
            +F+WG    G+LG   + +   P+ L E  K   ++ I  G  HSA +T  G L+  GL 
Sbjct: 3068 VFSWGEGDDGKLGHFSRMNCDKPR-LIEALKTKRIRDIACGSSHSAALTSSGELYTWGLG 3126

Query: 236  KDGQLGLGHTEDVLYFTLCKSLLGCPIQQVACGW--DFTIILTKNGQVLSCGSNSFGQLG 409
            + G+LG G     L   + K LLG  + QVACG     T+ LT  G V S G   FG+LG
Sbjct: 3127 EYGRLGHGDNTTQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFSWGDGDFGKLG 3186

Query: 410  VPHGPRRCVVPQAIE-VQREKVVSIXXXXXXXXXXXXSGLVFQWGTGLASSGRRLCPGQT 586
               G   C +PQ IE +  + V  I            SG+V+ WG G      RL  G  
Sbjct: 3187 -RGGSEGCNIPQNIERLNGQGVCQIECGAQFSLALTKSGVVWTWGKG---DYFRLGHGSD 3242

Query: 587  LPLFLTAKEPSKVTGLENSQAVCVLAGSGHSASLTDAGELYVWGSNKHGQLASQAAFLPL 766
            + +    ++P  V GL   + V V  G+ H  ++TD+G++Y WG N HGQ  +    +  
Sbjct: 3243 VHV----RKPQVVEGLRGKKIVHVAVGALHCLAVTDSGQVYAWGDNDHGQQGNGTTTVNR 3298

Query: 767  PQKIEAHRFQNEKVAAVWSGWTHLVAQT 850
               +     + +K+  V  G +H VA T
Sbjct: 3299 KPTL-VQGLEGQKITRVACGSSHSVAWT 3325



 Score =  110 bits (274), Expect = 4e-24
 Identities = 91/348 (26%), Positives = 148/348 (42%), Gaps = 11/348 (3%)
 Frame = +2

Query: 182  GHSAIVTDQGSLFVCGLNKDGQLGLGHTEDVLYFTLCKSLLGCPIQQVACGWDFTIILTK 361
            G  +  T +  +FV GLN   QLG      +   +  ++L    + QVA G      +T 
Sbjct: 2950 GLESAATIRTKVFVWGLNDKDQLGGLKGSKIKVPSFSETLSALNVVQVAGGSKSLFAVTV 3009

Query: 362  NGQVLSCGSNSFGQLGVPHGPRRCVVPQAIEVQRE---KVVSIXXXXXXXXXXXXSGLVF 532
             G+V +CG  + G+LG+        +P+ I        K V++             G VF
Sbjct: 3010 EGKVYACGEATNGRLGLGISSGTVPIPRQITALSSYVVKKVAVHSGGRHATALTVDGKVF 3069

Query: 533  QWGTG----LASSGRRLCPGQTLPLFLTAKEPSKVTGLENSQAVCVLAGSGHSASLTDAG 700
             WG G    L    R  C            +P  +  L+  +   +  GS HSA+LT +G
Sbjct: 3070 SWGEGDDGKLGHFSRMNC-----------DKPRLIEALKTKRIRDIACGSSHSAALTSSG 3118

Query: 701  ELYVWGSNKHGQLASQAAFLPL-PQKIEAHRFQNEKVAAVWSGWTHLVAQTETGKVFTWG 877
            ELY WG  ++G+L        L P+ ++          A  S     +A T+ G VF+WG
Sbjct: 3119 ELYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFSWG 3178

Query: 878  RADYGQLGRTLESPEGWKPKKQASSLPCSRPARSVPSSLPCLT--GATEVSCGSEHNLAV 1051
              D+G+LGR               S  C     ++P ++  L   G  ++ CG++ +LA+
Sbjct: 3179 DGDFGKLGR-------------GGSEGC-----NIPQNIERLNGQGVCQIECGAQFSLAL 3220

Query: 1052 V-GGTCYSWGWNEHGMCGDGTEANVWTPKPVQALRSSSGLRLGCGAGH 1192
               G  ++WG  ++   G G++ +V  P+ V+ LR    + +  GA H
Sbjct: 3221 TKSGVVWTWGKGDYFRLGHGSDVHVRKPQVVEGLRGKKIVHVAVGALH 3268



 Score =  108 bits (270), Expect = 1e-23
 Identities = 90/326 (27%), Positives = 143/326 (43%), Gaps = 9/326 (2%)
 Frame = +2

Query: 242  GQLGLGHTEDVLYFTLCKSLLGCPIQQVACGWDFTIILTKNGQVLSCGSNSFGQLGVPHG 421
            G +G  +  +V+    C+ L    + Q+AC     +IL++NG+V +   NS         
Sbjct: 429  GLIGWKYYANVIGPIQCEGLANLGVTQIACAEKRFLILSRNGRVYTQAYNS--------- 479

Query: 422  PRRCVVPQAIE-VQREKVVSIXXXXXXXXXXXXS--GLVFQWGTGLASSGRRLCPGQTLP 592
                + PQ ++ +    +V I            +  G V+ WG G    G RL  G T+P
Sbjct: 480  --DTLAPQLVQGLASRNIVKIAAHSDGHHYLALAATGEVYSWGCG---DGGRLGHGDTVP 534

Query: 593  LFLTAKEPSKVTGLENSQA----VCVLAGSGHSASLTDAGELYVWGSNKHGQLA-SQAAF 757
            L    +EP  ++     QA    V +  GS +SA++T  GELY WG   +G+L    +  
Sbjct: 535  L----EEPKVISAFSGKQAGKHVVHIACGSTYSAAITAEGELYTWGRGNYGRLGHGSSED 590

Query: 758  LPLPQKIEAHRFQNEKVAAVWSGWTHLVAQTETGKVFTWGRADYGQLGRTLESPEGWKPK 937
              +P  +   +       A  SG    +A TE G+V++WG  DYG+LGR     +G K  
Sbjct: 591  EAIPMLVAGLKGLKVIDVACGSGDAQTLAVTENGQVWSWGDGDYGKLGR--GGSDGCKTP 648

Query: 938  KQASSLPCSRPARSVPSSLPCLTGATEVSCGSEHNLAVV-GGTCYSWGWNEHGMCGDGTE 1114
            K    L                    +V CGS+ ++A+   G  YSWG  ++   G GTE
Sbjct: 649  KLIEKLQD--------------LDVVKVRCGSQFSIALTKDGQVYSWGKGDNQRLGHGTE 694

Query: 1115 ANVWTPKPVQALRSSSGLRLGCGAGH 1192
             +V  PK ++ L+    + +  G+ H
Sbjct: 695  EHVRYPKLLEGLQGKKVIDVAAGSTH 720



 Score =  102 bits (253), Expect = 1e-21
 Identities = 82/267 (30%), Positives = 122/267 (45%), Gaps = 4/267 (1%)
 Frame = +2

Query: 56   LFAWGANSYGQLGLGHKEDVLLPQQLSEFCKPGCVKRITGGGGHSAIVTDQGSLFVCGLN 235
            +++WG    G+LG G++     P+ + E  +   V  +  GG HSA VT  G L+  G  
Sbjct: 4060 VYSWGEAEDGKLGHGNRSPCDRPRVI-ESLRGIEVVDVAAGGAHSACVTAAGDLYTWGKG 4118

Query: 236  KDGQLGLGHTEDVLYFTLCKSLLGCPIQQVACGWDF--TIILTKNGQVLSCGSNSFGQLG 409
            + G+LG   +ED L   L ++L G  +  +ACG     T+ LT +  V S G   +G+LG
Sbjct: 4119 RYGRLGHSDSEDQLKPKLVEALQGHRVVDIACGSGDAQTLCLTDDDTVWSWGDGDYGKLG 4178

Query: 410  VPHGPRRCVVPQAIE-VQREKVVSIXXXXXXXXXXXXSGLVFQWGTGLASSGRRLCPGQT 586
               G   C VP  I+ +    VV +            SG V+ WG G      RL  G  
Sbjct: 4179 -RGGSDGCKVPMKIDSLTGLGVVKVECGSQFSVALTKSGAVYTWGKG---DYHRLGHGSD 4234

Query: 587  LPLFLTAKEPSKVTGLENSQAVCVLAGSGHSASLTDAGELYVWGSNKHGQLASQAA-FLP 763
              +    + P +V GL+  + + +  GS H    T+ GE+Y WG N  GQL       + 
Sbjct: 4235 DHV----RRPRQVQGLQGKKVIAIATGSLHCVCCTEDGEVYTWGDNDEGQLGDGTTNAIQ 4290

Query: 764  LPQKIEAHRFQNEKVAAVWSGWTHLVA 844
             P+ + A   Q +KV  V  G  H +A
Sbjct: 4291 RPRLVAA--LQGKKVNRVACGSAHTLA 4315



 Score = 97.8 bits (242), Expect = 2e-20
 Identities = 73/233 (31%), Positives = 108/233 (46%), Gaps = 6/233 (2%)
 Frame = +2

Query: 56   LFAWGANSYGQLGLGHKEDVLLPQQLSEFCKPGCVKRITG---GGGHSAIVTDQGSLFVC 226
            +++WG    G+LG G    +  P+ +S F      K +     G  +SA +T +G L+  
Sbjct: 516  VYSWGCGDGGRLGHGDTVPLEEPKVISAFSGKQAGKHVVHIACGSTYSAAITAEGELYTW 575

Query: 227  GLNKDGQLGLGHTEDVLYFTLCKSLLGCPIQQVACGWD--FTIILTKNGQVLSCGSNSFG 400
            G    G+LG G +ED     L   L G  +  VACG     T+ +T+NGQV S G   +G
Sbjct: 576  GRGNYGRLGHGSSEDEAIPMLVAGLKGLKVIDVACGSGDAQTLAVTENGQVWSWGDGDYG 635

Query: 401  QLGVPHGPRRCVVPQAIE-VQREKVVSIXXXXXXXXXXXXSGLVFQWGTGLASSGRRLCP 577
            +LG   G   C  P+ IE +Q   VV +             G V+ WG G     +RL  
Sbjct: 636  KLG-RGGSDGCKTPKLIEKLQDLDVVKVRCGSQFSIALTKDGQVYSWGKG---DNQRLGH 691

Query: 578  GQTLPLFLTAKEPSKVTGLENSQAVCVLAGSGHSASLTDAGELYVWGSNKHGQ 736
            G    +    + P  + GL+  + + V AGS H  +LT+  E++ WGSN   Q
Sbjct: 692  GTEEHV----RYPKLLEGLQGKKVIDVAAGSTHCLALTEDSEVHSWGSNDQCQ 740



 Score = 95.9 bits (237), Expect = 7e-20
 Identities = 92/343 (26%), Positives = 151/343 (44%), Gaps = 12/343 (3%)
 Frame = +2

Query: 56   LFAWGANSYGQLGLGHKEDVL-LPQQLSEFCKPGCVKRIT--GGGGHSAIVTDQGSLFVC 226
            ++A G  + G+LGLG     + +P+Q++       VK++    GG H+  +T  G +F  
Sbjct: 3013 VYACGEATNGRLGLGISSGTVPIPRQITALSSY-VVKKVAVHSGGRHATALTVDGKVFSW 3071

Query: 227  GLNKDGQLGLGHTEDVLYFTLCKSLLGCPIQQVACGWDFTIILTKNGQVLSCGSNSFGQL 406
            G   DG+LG     +     L ++L    I+ +ACG   +  LT +G++ + G   +G+L
Sbjct: 3072 GEGDDGKLGHFSRMNCDKPRLIEALKTKRIRDIACGSSHSAALTSSGELYTWGLGEYGRL 3131

Query: 407  GVPHGPRRCVV-PQAIEV---QREKVVSIXXXXXXXXXXXXSGLVFQWGTG-LASSGRRL 571
            G  HG     + P+ ++V    R   V+              GLVF WG G     GR  
Sbjct: 3132 G--HGDNTTQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFSWGDGDFGKLGRGG 3189

Query: 572  CPGQTLPLFLTAKEPSKVTGLENSQAVCVL-AGSGHSASLTDAGELYVWGSNKHGQLASQ 748
              G  +P  +            N Q VC +  G+  S +LT +G ++ WG   + +L   
Sbjct: 3190 SEGCNIPQNIERL---------NGQGVCQIECGAQFSLALTKSGVVWTWGKGDYFRLGHG 3240

Query: 749  A-AFLPLPQKIEAHRFQNEKVAAVWSGWTHLVAQTETGKVFTWGRADYGQLGRTLESPEG 925
            +   +  PQ +E  R   +K+  V  G  H +A T++G+V+ WG  D+GQ G    +   
Sbjct: 3241 SDVHVRKPQVVEGLR--GKKIVHVAVGALHCLAVTDSGQVYAWGDNDHGQQGNGTTT--- 3295

Query: 926  WKPKKQASSLPCSRPARSVPSSLPCLTGA--TEVSCGSEHNLA 1048
                               P+ +  L G   T V+CGS H++A
Sbjct: 3296 ---------------VNRKPTLVQGLEGQKITRVACGSSHSVA 3323



 Score = 79.7 bits (195), Expect = 5e-15
 Identities = 84/331 (25%), Positives = 136/331 (41%), Gaps = 46/331 (13%)
 Frame = +2

Query: 338  DFTIILTKNGQVLSCGSNSFGQLGVPHGPRRCVVPQAIEVQREKVVSIXXXXXXXXXXXX 517
            D+T+    +G +   G N  GQLG   G +  V      +   + V +            
Sbjct: 3943 DWTLSAGGSGTIYGWGHNHRGQLGGIEGAKVKVPTPCEALATLRPVQLIGGEQTLFAVTA 4002

Query: 518  SGLVFQWGTGLASSGRRLCPGQTLPLFLTAKEPSKVTGLENSQ-----AVCVLAGSGHSA 682
             G ++  G G   +G RL  G T       +  S  T LE+ Q      V V +G  H  
Sbjct: 4003 DGKLYATGYG---AGGRLGIGGT-------ESVSTPTLLESIQHVFIKKVAVNSGGKHCL 4052

Query: 683  SLTDAGELYVWGSNKHGQLA-SQAAFLPLPQKIEAHRFQNEKVAAVWSGWTHLVAQTETG 859
            +L+  GE+Y WG  + G+L     +    P+ IE+ R    +V  V +G  H    T  G
Sbjct: 4053 ALSSEGEVYSWGEAEDGKLGHGNRSPCDRPRVIESLR--GIEVVDVAAGGAHSACVTAAG 4110

Query: 860  KVFTWGRADYGQLGRTLESPEGWKPK-------KQASSLPC-SRPARS------------ 979
             ++TWG+  YG+LG + +S +  KPK        +   + C S  A++            
Sbjct: 4111 DLYTWGKGRYGRLGHS-DSEDQLKPKLVEALQGHRVVDIACGSGDAQTLCLTDDDTVWSW 4169

Query: 980  -----------------VPSSLPCLT--GATEVSCGSEHNLAVV-GGTCYSWGWNEHGMC 1099
                             VP  +  LT  G  +V CGS+ ++A+   G  Y+WG  ++   
Sbjct: 4170 GDGDYGKLGRGGSDGCKVPMKIDSLTGLGVVKVECGSQFSVALTKSGAVYTWGKGDYHRL 4229

Query: 1100 GDGTEANVWTPKPVQALRSSSGLRLGCGAGH 1192
            G G++ +V  P+ VQ L+    + +  G+ H
Sbjct: 4230 GHGSDDHVRRPRQVQGLQGKKVIAIATGSLH 4260



 Score = 78.2 bits (191), Expect = 2e-14
 Identities = 79/337 (23%), Positives = 130/337 (38%), Gaps = 9/337 (2%)
 Frame = +2

Query: 101  HKEDVLLPQQLSEFCKPGCVKRITGGGGHSAI-VTDQGSLFVCGLNKDGQLGLGHT---- 265
            +  D L PQ +        VK      GH  + +   G ++  G    G+LG G T    
Sbjct: 477  YNSDTLAPQLVQGLASRNIVKIAAHSDGHHYLALAATGEVYSWGCGDGGRLGHGDTVPLE 536

Query: 266  EDVLYFTLCKSLLGCPIQQVACGWDFTIILTKNGQVLSCGSNSFGQLGVPHGPRRCVVPQ 445
            E  +         G  +  +ACG  ++  +T  G++ + G  ++G+LG        +   
Sbjct: 537  EPKVISAFSGKQAGKHVVHIACGSTYSAAITAEGELYTWGRGNYGRLGHGSSEDEAIPML 596

Query: 446  AIEVQREKVVSIXXXXXXXXXXXXS--GLVFQWGTG-LASSGRRLCPGQTLPLFLTAKEP 616
               ++  KV+ +            +  G V+ WG G     GR    G         K P
Sbjct: 597  VAGLKGLKVIDVACGSGDAQTLAVTENGQVWSWGDGDYGKLGRGGSDG--------CKTP 648

Query: 617  SKVTGLENSQAVCVLAGSGHSASLTDAGELYVWGSNKHGQLA-SQAAFLPLPQKIEAHRF 793
              +  L++   V V  GS  S +LT  G++Y WG   + +L       +  P+ +E    
Sbjct: 649  KLIEKLQDLDVVKVRCGSQFSIALTKDGQVYSWGKGDNQRLGHGTEEHVRYPKLLEG--L 706

Query: 794  QNEKVAAVWSGWTHLVAQTETGKVFTWGRADYGQLGRTLESPEGWKPKKQASSLPCSRPA 973
            Q +KV  V +G TH +A TE  +V +WG  D  Q   TL                  R  
Sbjct: 707  QGKKVIDVAAGSTHCLALTEDSEVHSWGSNDQCQHFDTL------------------RVT 748

Query: 974  RSVPSSLPCLTGATEVSCGSEHNLAVVGGTCYSWGWN 1084
            +  P++LP L         ++H + +  G   S+ W+
Sbjct: 749  KPEPAALPGL--------DTKHIVGIACGPAQSFAWS 777



 Score = 72.4 bits (176), Expect = 8e-13
 Identities = 61/219 (27%), Positives = 95/219 (43%), Gaps = 3/219 (1%)
 Frame = +2

Query: 56   LFAWGANSYGQLGLGHKEDVLLPQQLSEFCKPGCVKRITGGGGHSAI-VTDQGSLFVCGL 232
            L+ WG  +YG+LG G  ED  +P  ++       +    G G    + VT+ G ++  G 
Sbjct: 572  LYTWGRGNYGRLGHGSSEDEAIPMLVAGLKGLKVIDVACGSGDAQTLAVTENGQVWSWGD 631

Query: 233  NKDGQLGLGHTEDVLYFTLCKSLLGCPIQQVACGWDFTIILTKNGQVLSCGSNSFGQLGV 412
               G+LG G ++      L + L    + +V CG  F+I LTK+GQV S G     +LG 
Sbjct: 632  GDYGKLGRGGSDGCKTPKLIEKLQDLDVVKVRCGSQFSIALTKDGQVYSWGKGDNQRLG- 690

Query: 413  PHGPRRCV-VPQAIE-VQREKVVSIXXXXXXXXXXXXSGLVFQWGTGLASSGRRLCPGQT 586
             HG    V  P+ +E +Q +KV+ +               V  WG     S  +     T
Sbjct: 691  -HGTEEHVRYPKLLEGLQGKKVIDVAAGSTHCLALTEDSEVHSWG-----SNDQCQHFDT 744

Query: 587  LPLFLTAKEPSKVTGLENSQAVCVLAGSGHSASLTDAGE 703
            L   +T  EP+ + GL+    V +  G   S + +   E
Sbjct: 745  LR--VTKPEPAALPGLDTKHIVGIACGPAQSFAWSSCSE 781



 Score = 70.5 bits (171), Expect = 3e-12
 Identities = 59/204 (28%), Positives = 89/204 (43%), Gaps = 10/204 (4%)
 Frame = +2

Query: 614  PSKVTGLENSQAVCVLAGSG--HSASLTDAGELYVWGSNKHGQLA-SQAAFLPLPQKIEA 784
            P  V GL +   V + A S   H  +L   GE+Y WG    G+L       L  P+ I A
Sbjct: 484  PQLVQGLASRNIVKIAAHSDGHHYLALAATGEVYSWGCGDGGRLGHGDTVPLEEPKVISA 543

Query: 785  H--RFQNEKVAAVWSGWTHLVAQTETGKVFTWGRADYGQLGRTLESPEGWKPKKQASSLP 958
               +   + V  +  G T+  A T  G+++TWGR +YG+LG      E            
Sbjct: 544  FSGKQAGKHVVHIACGSTYSAAITAEGELYTWGRGNYGRLGHGSSEDE------------ 591

Query: 959  CSRPARSVPSSLPCLTG--ATEVSCGS--EHNLAVV-GGTCYSWGWNEHGMCGDGTEANV 1123
                  ++P  +  L G    +V+CGS     LAV   G  +SWG  ++G  G G     
Sbjct: 592  ------AIPMLVAGLKGLKVIDVACGSGDAQTLAVTENGQVWSWGDGDYGKLGRGGSDGC 645

Query: 1124 WTPKPVQALRSSSGLRLGCGAGHS 1195
             TPK ++ L+    +++ CG+  S
Sbjct: 646  KTPKLIEKLQDLDVVKVRCGSQFS 669



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 32/99 (32%), Positives = 49/99 (49%)
 Frame = +2

Query: 53   ALFAWGANSYGQLGLGHKEDVLLPQQLSEFCKPGCVKRITGGGGHSAIVTDQGSLFVCGL 232
            A++ WG   Y +LG G  + V  P+Q+ +  +   V  I  G  H    T+ G ++  G 
Sbjct: 4217 AVYTWGKGDYHRLGHGSDDHVRRPRQV-QGLQGKKVIAIATGSLHCVCCTEDGEVYTWGD 4275

Query: 233  NKDGQLGLGHTEDVLYFTLCKSLLGCPIQQVACGWDFTI 349
            N +GQLG G T  +    L  +L G  + +VACG   T+
Sbjct: 4276 NDEGQLGDGTTNAIQRPRLVAALQGKKVNRVACGSAHTL 4314


>ref|NP_060661.3| RCC1 and BTB domain-containing protein 1 [Homo sapiens].
          Length = 531

 Score =  103 bits (258), Expect = 3e-22
 Identities = 81/286 (28%), Positives = 130/286 (45%), Gaps = 11/286 (3%)
 Frame = +2

Query: 56  LFAWGANSYGQLGLGHKEDVLLPQQLSEFCKPGCVKRITGGGGHSAIVTDQGSLFVCGLN 235
           +F +G N    LG G  +  L+P++L   C         G G H  + T+ G ++  G N
Sbjct: 43  VFVFGLNYSNCLGTGDNQSTLVPKKLEGLCGKKIKSLSYGSGPHVLLSTEDGVVYAWGHN 102

Query: 236 KDGQLGLGHT-EDVLYFTLCKSLLGCPIQQVACGWDFTIILTKNGQVLSCGSNSFGQLG- 409
              QLG G T + +    +C +LL   + +VACG   ++ L  +G+V + G N+ GQ+G 
Sbjct: 103 GYSQLGNGTTNQGIAPVQVCTNLLIKQVVEVACGSHHSMALAADGEVFAWGYNNCGQVGS 162

Query: 410 --VPHGPRRCVVPQAIEVQREKVVSIXXXXXXXXXXXXSGLVFQWG------TGLASSGR 565
               + P    V   + ++R  VV I            +G V+ WG       GL ++G 
Sbjct: 163 GSTANQPTPRKVTNCLHIKR--VVGIACGQTSSMAVLDNGEVYGWGYNGNGQLGLGNNGN 220

Query: 566 RLCPGQTLPLFLTAKEPSKVTGLENSQAVCVLAGSGHSASLTDAGELYVWGSNKHGQLAS 745
           +L              P +V  L +     ++ G  H+ +LTD G LY WG+N +GQL +
Sbjct: 221 QL-------------TPVRVAALHSVCVNQIVCGYAHTLALTDEGLLYAWGANTYGQLGT 267

Query: 746 -QAAFLPLPQKIEAHRFQNEKVAAVWSGWTHLVAQTETGKVFTWGR 880
                L  P  I   + +  ++AA  S  T   A+T+ G V+ WG+
Sbjct: 268 GNKNNLLSPAHIMVEKERVVEIAACHSAHTS-AAKTQGGHVYMWGQ 312



 Score = 79.3 bits (194), Expect = 7e-15
 Identities = 79/274 (28%), Positives = 118/274 (43%), Gaps = 11/274 (4%)
 Frame = +2

Query: 113 VLLPQQLSEFCKPGCVKRITGGGGHSAIVTDQGSLFVCGLNKDGQLGLGHTEDVLYFTLC 292
           +L PQ+++   K  CV         +  VTD   +FV GLN    LG G  +  L     
Sbjct: 12  LLSPQEIASIRK-ACV--FGTSASEALYVTDNDEVFVFGLNYSNCLGTGDNQSTLVPKKL 68

Query: 293 KSLLGCPIQQVACGWDFTIIL-TKNGQVLSCGSNSFGQLGVPHGPRR---CVVPQAIEVQ 460
           + L G  I+ ++ G    ++L T++G V + G N + QLG  +G        V     + 
Sbjct: 69  EGLCGKKIKSLSYGSGPHVLLSTEDGVVYAWGHNGYSQLG--NGTTNQGIAPVQVCTNLL 126

Query: 461 REKVVSIXXXXXXXXXXXXSGLVFQWG---TGLASSGRRLCPGQTLPLFLTAKEPS--KV 625
            ++VV +             G VF WG    G   SG             TA +P+  KV
Sbjct: 127 IKQVVEVACGSHHSMALAADGEVFAWGYNNCGQVGSGS------------TANQPTPRKV 174

Query: 626 TG-LENSQAVCVLAGSGHSASLTDAGELYVWGSNKHGQLASQAAFLPL-PQKIEAHRFQN 799
           T  L   + V +  G   S ++ D GE+Y WG N +GQL        L P ++ A    +
Sbjct: 175 TNCLHIKRVVGIACGQTSSMAVLDNGEVYGWGYNGNGQLGLGNNGNQLTPVRVAA--LHS 232

Query: 800 EKVAAVWSGWTHLVAQTETGKVFTWGRADYGQLG 901
             V  +  G+ H +A T+ G ++ WG   YGQLG
Sbjct: 233 VCVNQIVCGYAHTLALTDEGLLYAWGANTYGQLG 266



 Score = 73.6 bits (179), Expect = 4e-13
 Identities = 57/198 (28%), Positives = 83/198 (41%), Gaps = 4/198 (2%)
 Frame = +2

Query: 614  PSKVTGLENSQAVCVLAGSG-HSASLTDAGELYVWGSNKHGQLASQAAFLPLPQKIEAHR 790
            P K+ GL   +   +  GSG H    T+ G +Y WG N + QL +      +        
Sbjct: 65   PKKLEGLCGKKIKSLSYGSGPHVLLSTEDGVVYAWGHNGYSQLGNGTTNQGIAPVQVCTN 124

Query: 791  FQNEKVAAVWSGWTHLVAQTETGKVFTWGRADYGQLGR--TLESPEGWKPKKQASSLPCS 964
               ++V  V  G  H +A    G+VF WG  + GQ+G   T   P    P+K  + L   
Sbjct: 125  LLIKQVVEVACGSHHSMALAADGEVFAWGYNNCGQVGSGSTANQPT---PRKVTNCLHIK 181

Query: 965  RPARSVPSSLPCLTGATEVSCGSEHNLAVV-GGTCYSWGWNEHGMCGDGTEANVWTPKPV 1141
            R                 ++CG   ++AV+  G  Y WG+N +G  G G   N  TP  V
Sbjct: 182  R--------------VVGIACGQTSSMAVLDNGEVYGWGYNGNGQLGLGNNGNQLTPVRV 227

Query: 1142 QALRSSSGLRLGCGAGHS 1195
             AL S    ++ CG  H+
Sbjct: 228  AALHSVCVNQIVCGYAHT 245


>ref|NP_001259.1| RCC1 and BTB domain-containing protein 2 [Homo sapiens].
          Length = 551

 Score =  102 bits (255), Expect = 6e-22
 Identities = 82/287 (28%), Positives = 129/287 (44%), Gaps = 12/287 (4%)
 Frame = +2

Query: 56  LFAWGANSYGQLGLGHKEDVLLPQQLSEFCKPGCVKRITGGGGHSAIVTDQGSLFVCGLN 235
           +F  G N  G LGLG  +  + P++L             G G H  + T +G +F  G N
Sbjct: 67  IFVLGTNCCGCLGLGDVQSTIEPRRLDSLNGKKIACLSYGSGPHIVLATTEGEVFTWGHN 126

Query: 236 KDGQLGLGHTEDVLY-FTLCKSLLGCPIQQVACGWDFTIILTKNGQVLSCGSNSFGQLGV 412
              QLG G T   L    +  +L    + +VACG   +++LT +G+V + G N+ GQ+G 
Sbjct: 127 AYSQLGNGTTNHGLVPCHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGS 186

Query: 413 PHGPRRCVVPQAIE--VQREKVVSIXXXXXXXXXXXXSGLVFQWG------TGLASSGRR 568
                +  +P+ +   +Q + VV+I            +G V+ WG       GL +SG +
Sbjct: 187 GSTVNQ-PIPRRVTGCLQNKVVVTIACGQMCCMAVVDTGEVYVWGYNGNGQLGLGNSGNQ 245

Query: 569 LCPGQTLPLFLTAKEPSKVTGLENSQAVCVLAGSGHSASLTDAGELYVWGSNKHGQLAS- 745
                          P +V  L+  +   V  G  H+  LTD G++Y WG+N +GQL + 
Sbjct: 246 -------------PTPCRVAALQGIRVQRVACGYAHTLVLTDEGQVYAWGANSYGQLGTG 292

Query: 746 --QAAFLPLPQKIEAHRFQNEKVAAVWSGWTHLVAQTETGKVFTWGR 880
                  P P  +E  R    ++AA  S  T   A+T+ G V+ WG+
Sbjct: 293 NKSNQSYPTPVTVEKDRI--IEIAACHSTHTS-AAKTQGGHVYMWGQ 336



 Score = 95.9 bits (237), Expect = 7e-20
 Identities = 78/264 (29%), Positives = 120/264 (45%), Gaps = 10/264 (3%)
 Frame = +2

Query: 167 ITGGGGHSAIVTD-QGSLFVCGLNKDGQLGLGHTEDVLYFTLCKSLLGCPIQQVACGWDF 343
           + G  G+  + T     +FV G N  G LGLG  +  +      SL G  I  ++ G   
Sbjct: 50  VFGSAGNEVLYTTVNDEIFVLGTNCCGCLGLGDVQSTIEPRRLDSLNGKKIACLSYGSGP 109

Query: 344 TIIL-TKNGQVLSCGSNSFGQLG---VPHGPRRCVVPQAIEVQREKVVSIXXXXXXXXXX 511
            I+L T  G+V + G N++ QLG     HG   C +  +  +  ++V+ +          
Sbjct: 110 HIVLATTEGEVFTWGHNAYSQLGNGTTNHGLVPCHI--STNLSNKQVIEVACGSYHSLVL 167

Query: 512 XXSGLVFQWG---TGLASSGRRLCPGQTLPLFLTAKEPSKVTG-LENSQAVCVLAGSGHS 679
              G VF WG   +G   SG  +      P+      P +VTG L+N   V +  G    
Sbjct: 168 TSDGEVFAWGYNNSGQVGSGSTV----NQPI------PRRVTGCLQNKVVVTIACGQMCC 217

Query: 680 ASLTDAGELYVWGSNKHGQLA-SQAAFLPLPQKIEAHRFQNEKVAAVWSGWTHLVAQTET 856
            ++ D GE+YVWG N +GQL    +   P P ++ A   Q  +V  V  G+ H +  T+ 
Sbjct: 218 MAVVDTGEVYVWGYNGNGQLGLGNSGNQPTPCRVAA--LQGIRVQRVACGYAHTLVLTDE 275

Query: 857 GKVFTWGRADYGQLGRTLESPEGW 928
           G+V+ WG   YGQLG   +S + +
Sbjct: 276 GQVYAWGANSYGQLGTGNKSNQSY 299



 Score = 85.5 bits (210), Expect = 9e-17
 Identities = 74/269 (27%), Positives = 112/269 (41%), Gaps = 7/269 (2%)
 Frame = +2

Query: 356  TKNGQVLSCGSNSFGQLGVPHGPRRCVVPQAIEVQREKVVSIXXXXXXXXXXXXS--GLV 529
            T N ++   G+N  G LG+    +  + P+ ++    K ++             +  G V
Sbjct: 62   TVNDEIFVLGTNCCGCLGLGD-VQSTIEPRRLDSLNGKKIACLSYGSGPHIVLATTEGEV 120

Query: 530  FQWGTGLASS-GRRLCPGQTLPLFLTAKEPSKVTGLENSQAVCVLAGSGHSASLTDAGEL 706
            F WG    S  G        +P  ++       T L N Q + V  GS HS  LT  GE+
Sbjct: 121  FTWGHNAYSQLGNGTTNHGLVPCHIS-------TNLSNKQVIEVACGSYHSLVLTSDGEV 173

Query: 707  YVWGSNKHGQLASQAAF-LPLPQKIEAHRFQNEKVAAVWSGWTHLVAQTETGKVFTWGRA 883
            + WG N  GQ+ S +    P+P+++     QN+ V  +  G    +A  +TG+V+ WG  
Sbjct: 174  FAWGYNNSGQVGSGSTVNQPIPRRVTGC-LQNKVVVTIACGQMCCMAVVDTGEVYVWGYN 232

Query: 884  DYGQLGRTLESPEGWKPKKQASSLPCSRPARSVPSSLPCLTG--ATEVSCGSEHNLAVVG 1057
              GQLG       G +P                P  +  L G     V+CG  H L +  
Sbjct: 233  GNGQLGL---GNSGNQP---------------TPCRVAALQGIRVQRVACGYAHTLVLTD 274

Query: 1058 -GTCYSWGWNEHGMCGDGTEANVWTPKPV 1141
             G  Y+WG N +G  G G ++N   P PV
Sbjct: 275  EGQVYAWGANSYGQLGTGNKSNQSYPTPV 303



 Score = 77.8 bits (190), Expect = 2e-14
 Identities = 61/199 (30%), Positives = 86/199 (43%), Gaps = 4/199 (2%)
 Frame = +2

Query: 611  EPSKVTGLENSQAVCVLAGSG-HSASLTDAGELYVWGSNKHGQLASQAAFLPLPQKIEAH 787
            EP ++  L   +  C+  GSG H    T  GE++ WG N + QL +      L     + 
Sbjct: 88   EPRRLDSLNGKKIACLSYGSGPHIVLATTEGEVFTWGHNAYSQLGNGTTNHGLVPCHIST 147

Query: 788  RFQNEKVAAVWSGWTHLVAQTETGKVFTWGRADYGQLGR--TLESPEGWKPKKQASSLPC 961
               N++V  V  G  H +  T  G+VF WG  + GQ+G   T+  P           +P 
Sbjct: 148  NLSNKQVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTVNQP-----------IP- 195

Query: 962  SRPARSVPSSLPCLTGATEVSCGSEHNLAVVG-GTCYSWGWNEHGMCGDGTEANVWTPKP 1138
                R V   L      T ++CG    +AVV  G  Y WG+N +G  G G   N  TP  
Sbjct: 196  ----RRVTGCLQNKVVVT-IACGQMCCMAVVDTGEVYVWGYNGNGQLGLGNSGNQPTPCR 250

Query: 1139 VQALRSSSGLRLGCGAGHS 1195
            V AL+     R+ CG  H+
Sbjct: 251  VAALQGIRVQRVACGYAHT 269



 Score = 77.0 bits (188), Expect = 3e-14
 Identities = 66/248 (26%), Positives = 101/248 (40%), Gaps = 12/248 (4%)
 Frame = +2

Query: 56  LFAWGANSYGQLGLGHKEDVLLPQQLSEFCKPGCVKRITGGGGHSAIVTDQGSLFVCGLN 235
           +F WG N+Y QLG G     L+P  +S       V  +  G  HS ++T  G +F  G N
Sbjct: 120 VFTWGHNAYSQLGNGTTNHGLVPCHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWGYN 179

Query: 236 KDGQLGLGHTEDVLYFTLCKSLLGC----PIQQVACGWDFTIILTKNGQVLSCGSNSFGQ 403
             GQ+G G T +     + + + GC     +  +ACG    + +   G+V   G N  GQ
Sbjct: 180 NSGQVGSGSTVNQ---PIPRRVTGCLQNKVVVTIACGQMCCMAVVDTGEVYVWGYNGNGQ 236

Query: 404 LGVPHG-----PRRCVVPQAIEVQREKVVSIXXXXXXXXXXXXSGLVFQWGT---GLASS 559
           LG+ +      P R    Q I VQR     +             G V+ WG    G   +
Sbjct: 237 LGLGNSGNQPTPCRVAALQGIRVQR-----VACGYAHTLVLTDEGQVYAWGANSYGQLGT 291

Query: 560 GRRLCPGQTLPLFLTAKEPSKVTGLENSQAVCVLAGSGHSASLTDAGELYVWGSNKHGQL 739
           G +    Q+ P  +T ++   +        +     +  SA+ T  G +Y+W     GQ 
Sbjct: 292 GNK--SNQSYPTPVTVEKDRII-------EIAACHSTHTSAAKTQGGHVYMW-----GQC 337

Query: 740 ASQAAFLP 763
             Q+  LP
Sbjct: 338 RGQSVILP 345


>ref|NP_000319.1| X-linked retinitis pigmentosa GTPase regulator isoform A [Homo
           sapiens].
          Length = 815

 Score = 99.0 bits (245), Expect = 8e-21
 Identities = 77/288 (26%), Positives = 137/288 (47%), Gaps = 1/288 (0%)
 Frame = +2

Query: 56  LFAWGANSYGQLGLGHKEDVLLPQQLSEFCKPGCVKRITGGGGHSAIVTDQGSLFVCGLN 235
           L+ +G+N++GQLGLG K  +  P  +    KP  VK    G  H+ + T+ G+++  G N
Sbjct: 56  LYMFGSNNWGQLGLGSKSAISKPTCVKAL-KPEKVKLAACGRNHTLVSTEGGNVYATGGN 114

Query: 236 KDGQLGLGHTEDVLYFTLCKSLLG-CPIQQVACGWDFTIILTKNGQVLSCGSNSFGQLGV 412
            +GQLGLG TE+   F +         I+Q++ G + +  LT++G++   G NS GQ+G+
Sbjct: 115 NEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDGRLFMWGDNSEGQIGL 174

Query: 413 PHGPRRCVVPQAIEVQREKVVSIXXXXXXXXXXXXSGLVFQWGTGLASSGRRLCPGQTLP 592
            +    C VPQ + + +  V  I             G ++ +G     +G+   P Q L 
Sbjct: 175 KNVSNVC-VPQQVTIGK-PVSWISCGYYHSAFVTTDGELYVFGE--PENGKLGLPNQLLG 230

Query: 593 LFLTAKEPSKVTGLENSQAVCVLAGSGHSASLTDAGELYVWGSNKHGQLASQAAFLPLPQ 772
              T +  S++      + + V  G  H+  LT+   +Y +G  + GQL          +
Sbjct: 231 NHRTPQLVSEIP----EKVIQVACGGEHTVVLTE-NAVYTFGLGQFGQLGLGTFLFETSE 285

Query: 773 KIEAHRFQNEKVAAVWSGWTHLVAQTETGKVFTWGRADYGQLGRTLES 916
                  +++ ++ +  G  H    T+ G ++T+G   +G+LG  LE+
Sbjct: 286 PKVIENIRDQTISYISCGENHTALITDIGLMYTFGDGRHGKLGLGLEN 333



 Score = 95.1 bits (235), Expect = 1e-19
 Identities = 88/316 (27%), Positives = 129/316 (40%), Gaps = 3/316 (0%)
 Frame = +2

Query: 176  GGGHSAIVTDQGSLFVCGLNKDGQLGLGHTEDVLYFTLCKSLLGCPIQQVACGWDFTIIL 355
            G  HSA+VT    L++ G N  GQLGLG    +   T  K+L    ++  ACG + T++ 
Sbjct: 43   GDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHTLVS 102

Query: 356  TKNGQVLSCGSNSFGQLGVPHGPRRCVVPQ-AIEVQREKVVSIXXXXXXXXXXXXSGLVF 532
            T+ G V + G N+ GQLG+     R      +      K+  +             G +F
Sbjct: 103  TEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDGRLF 162

Query: 533  QWGTGLASS-GRRLCPGQTLPLFLTAKEPSKVTGLENSQAVCVLAGSGHSASLTDAGELY 709
             WG       G +      +P  +T  +P             +  G  HSA +T  GELY
Sbjct: 163  MWGDNSEGQIGLKNVSNVCVPQQVTIGKP----------VSWISCGYYHSAFVTTDGELY 212

Query: 710  VWGSNKHGQLASQAAFLPLPQKIEAHRFQNEKVAAVWSGWTHLVAQTETGKVFTWGRADY 889
            V+G  ++G+L      L   +  +      EKV  V  G  H V  TE   V+T+G   +
Sbjct: 213  VFGEPENGKLGLPNQLLGNHRTPQLVSEIPEKVIQVACGGEHTVVLTENA-VYTFGLGQF 271

Query: 890  GQLGRTLESPEGWKPKKQASSLPCSRPARSVPSSLPCLTGATEVSCGSEHNLAVVG-GTC 1066
            GQLG      E  +PK              V  ++   T  + +SCG  H   +   G  
Sbjct: 272  GQLGLGTFLFETSEPK--------------VIENIRDQT-ISYISCGENHTALITDIGLM 316

Query: 1067 YSWGWNEHGMCGDGTE 1114
            Y++G   HG  G G E
Sbjct: 317  YTFGDGRHGKLGLGLE 332



 Score = 52.8 bits (125), Expect = 7e-07
 Identities = 31/96 (32%), Positives = 51/96 (53%), Gaps = 2/96 (2%)
 Frame = +2

Query: 53  ALFAWGANSYGQLGLGHKEDVLLPQQLSEFCKPGCVKRITGGGGHSAIVTDQGSLFVCGL 232
           A++ +G   +GQLGLG         ++ E  +   +  I+ G  H+A++TD G ++  G 
Sbjct: 262 AVYTFGLGQFGQLGLGTFLFETSEPKVIENIRDQTISYISCGENHTALITDIGLMYTFGD 321

Query: 233 NKDGQLGLGHTEDVLYF--TLCKSLLGCPIQQVACG 334
            + G+LGLG      +F  TLC + L   ++ VACG
Sbjct: 322 GRHGKLGLGLENFTNHFIPTLCSNFLRFIVKLVACG 357


>ref|NP_001030025.1| X-linked retinitis pigmentosa GTPase regulator isoform C [Homo
           sapiens].
          Length = 1152

 Score = 99.0 bits (245), Expect = 8e-21
 Identities = 77/288 (26%), Positives = 137/288 (47%), Gaps = 1/288 (0%)
 Frame = +2

Query: 56  LFAWGANSYGQLGLGHKEDVLLPQQLSEFCKPGCVKRITGGGGHSAIVTDQGSLFVCGLN 235
           L+ +G+N++GQLGLG K  +  P  +    KP  VK    G  H+ + T+ G+++  G N
Sbjct: 56  LYMFGSNNWGQLGLGSKSAISKPTCVKAL-KPEKVKLAACGRNHTLVSTEGGNVYATGGN 114

Query: 236 KDGQLGLGHTEDVLYFTLCKSLLG-CPIQQVACGWDFTIILTKNGQVLSCGSNSFGQLGV 412
            +GQLGLG TE+   F +         I+Q++ G + +  LT++G++   G NS GQ+G+
Sbjct: 115 NEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDGRLFMWGDNSEGQIGL 174

Query: 413 PHGPRRCVVPQAIEVQREKVVSIXXXXXXXXXXXXSGLVFQWGTGLASSGRRLCPGQTLP 592
            +    C VPQ + + +  V  I             G ++ +G     +G+   P Q L 
Sbjct: 175 KNVSNVC-VPQQVTIGK-PVSWISCGYYHSAFVTTDGELYVFGE--PENGKLGLPNQLLG 230

Query: 593 LFLTAKEPSKVTGLENSQAVCVLAGSGHSASLTDAGELYVWGSNKHGQLASQAAFLPLPQ 772
              T +  S++      + + V  G  H+  LT+   +Y +G  + GQL          +
Sbjct: 231 NHRTPQLVSEIP----EKVIQVACGGEHTVVLTE-NAVYTFGLGQFGQLGLGTFLFETSE 285

Query: 773 KIEAHRFQNEKVAAVWSGWTHLVAQTETGKVFTWGRADYGQLGRTLES 916
                  +++ ++ +  G  H    T+ G ++T+G   +G+LG  LE+
Sbjct: 286 PKVIENIRDQTISYISCGENHTALITDIGLMYTFGDGRHGKLGLGLEN 333



 Score = 95.1 bits (235), Expect = 1e-19
 Identities = 88/316 (27%), Positives = 129/316 (40%), Gaps = 3/316 (0%)
 Frame = +2

Query: 176  GGGHSAIVTDQGSLFVCGLNKDGQLGLGHTEDVLYFTLCKSLLGCPIQQVACGWDFTIIL 355
            G  HSA+VT    L++ G N  GQLGLG    +   T  K+L    ++  ACG + T++ 
Sbjct: 43   GDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHTLVS 102

Query: 356  TKNGQVLSCGSNSFGQLGVPHGPRRCVVPQ-AIEVQREKVVSIXXXXXXXXXXXXSGLVF 532
            T+ G V + G N+ GQLG+     R      +      K+  +             G +F
Sbjct: 103  TEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDGRLF 162

Query: 533  QWGTGLASS-GRRLCPGQTLPLFLTAKEPSKVTGLENSQAVCVLAGSGHSASLTDAGELY 709
             WG       G +      +P  +T  +P             +  G  HSA +T  GELY
Sbjct: 163  MWGDNSEGQIGLKNVSNVCVPQQVTIGKP----------VSWISCGYYHSAFVTTDGELY 212

Query: 710  VWGSNKHGQLASQAAFLPLPQKIEAHRFQNEKVAAVWSGWTHLVAQTETGKVFTWGRADY 889
            V+G  ++G+L      L   +  +      EKV  V  G  H V  TE   V+T+G   +
Sbjct: 213  VFGEPENGKLGLPNQLLGNHRTPQLVSEIPEKVIQVACGGEHTVVLTENA-VYTFGLGQF 271

Query: 890  GQLGRTLESPEGWKPKKQASSLPCSRPARSVPSSLPCLTGATEVSCGSEHNLAVVG-GTC 1066
            GQLG      E  +PK              V  ++   T  + +SCG  H   +   G  
Sbjct: 272  GQLGLGTFLFETSEPK--------------VIENIRDQT-ISYISCGENHTALITDIGLM 316

Query: 1067 YSWGWNEHGMCGDGTE 1114
            Y++G   HG  G G E
Sbjct: 317  YTFGDGRHGKLGLGLE 332



 Score = 52.8 bits (125), Expect = 7e-07
 Identities = 31/96 (32%), Positives = 51/96 (53%), Gaps = 2/96 (2%)
 Frame = +2

Query: 53  ALFAWGANSYGQLGLGHKEDVLLPQQLSEFCKPGCVKRITGGGGHSAIVTDQGSLFVCGL 232
           A++ +G   +GQLGLG         ++ E  +   +  I+ G  H+A++TD G ++  G 
Sbjct: 262 AVYTFGLGQFGQLGLGTFLFETSEPKVIENIRDQTISYISCGENHTALITDIGLMYTFGD 321

Query: 233 NKDGQLGLGHTEDVLYF--TLCKSLLGCPIQQVACG 334
            + G+LGLG      +F  TLC + L   ++ VACG
Sbjct: 322 GRHGKLGLGLENFTNHFIPTLCSNFLRFIVKLVACG 357


>ref|NP_003913.3| probable E3 ubiquitin-protein ligase HERC1 [Homo sapiens].
          Length = 4861

 Score = 97.8 bits (242), Expect = 2e-20
 Identities = 103/383 (26%), Positives = 155/383 (40%), Gaps = 45/383 (11%)
 Frame = +2

Query: 182  GHSAIVTDQGSLFVCGLNKDGQLGLGHTEDVLYFTLCKSLLGCPIQQVACGWDFTIILTK 361
            G + IV++   ++V G N   QL  G  E +L   L  S      Q +  G   T +++ 
Sbjct: 363  GDAPIVSETCEVYVWGSNSSHQLVEGTQEKILQPKLAPSFSDA--QTIEAGQYCTFVIST 420

Query: 362  NGQVLSCGSNSFGQLGVPHGPRRCVVPQ-AIEVQR--EKVVSIXXXXXXXXXXXXSGLVF 532
            +G V +CG  S+G+LG+     +  + +   E  R  +KV S              G VF
Sbjct: 421  DGSVRACGKGSYGRLGLGDSNNQSTLKKLTFEPHRSIKKVSSSKGSDGHTLAFTTEGEVF 480

Query: 533  QWGTGLASSGRRLCPGQTLPLFLTAKEPSKVTG-LENSQAVCVLAGSGHSASLTDAGELY 709
             WG G      +L  G +     T K P  + G L+    VCV AG  HSA++T+ GELY
Sbjct: 481  SWGDG---DYGKLGHGNS----STQKYPKLIQGPLQGKVVVCVSAGYRHSAAVTEDGELY 533

Query: 710  VWGSNKHGQLA---SQAAFLPLPQKIEAHRFQNEKVAAVWSGWTHLVAQTETGK-VFTWG 877
             WG    G+L    S +  +P   K          V  V  G +H +A ++ G+ V+++G
Sbjct: 534  TWGEGDFGRLGHGDSNSRNIPTLVK------DISNVGEVSCGSSHTIALSKDGRTVWSFG 587

Query: 878  RADYGQLG----------RTLESPEGWKPKKQASSLPCSRPARSV--------PSSLPC- 1000
              D G+LG          + +E+ +G   +K  +    S    S          + L C 
Sbjct: 588  GGDNGKLGHGDTNRVYKPKVIEALQGMFIRKVCAGSQSSLALTSTGQVYAWGCGACLGCG 647

Query: 1001 ----------------LTGATEVSCGSEHNLAVV-GGTCYSWGWNEHGMCGDGTEAN-VW 1126
                             T   +VS G  H LA+      Y+WG N  G CG G     + 
Sbjct: 648  SSEATALRPKLIEELAATRIVDVSIGDSHCLALSHDNEVYAWGNNSMGQCGQGNSTGPIT 707

Query: 1127 TPKPVQALRSSSGLRLGCGAGHS 1195
             PK V  L   +  ++  G  HS
Sbjct: 708  KPKKVSGLDGIAIQQISAGTSHS 730



 Score = 93.2 bits (230), Expect = 5e-19
 Identities = 90/335 (26%), Positives = 142/335 (42%), Gaps = 42/335 (12%)
 Frame = +2

Query: 317  QQVACGWDFTIILTKNGQVLSCGSNSFGQLGVPHGPRRCVVPQAIEVQR---EKVVSIXX 487
            QQV CG + T ++  NG VL+CG  S+G+LG  +     V+     +Q     ++V+   
Sbjct: 4030 QQVICGQNCTFVIQANGTVLACGEGSYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCG 4089

Query: 488  XXXXXXXXXXSGLVFQWGTGLASSGRRLCPGQTLPLFLTAKEPSKVTGLENSQAVCVLAG 667
                      SG VF WG G      +L  G +       + P ++  L+  + V +  G
Sbjct: 4090 SDGHSMALTESGEVFSWGDG---DYGKLGHGNS----DRQRRPRQIEALQGEEVVQMSCG 4142

Query: 668  SGHSASLTDAGELYVWGSNKHGQLA-SQAAFLPLPQKIEAHRFQNEKVAAVWSGWTHLVA 844
              HSA +T  G+L+ +G+  +G+L     +   LP+++ A   +  ++  V  G  H +A
Sbjct: 4143 FKHSAVVTSDGKLFTFGNGDYGRLGLGNTSNKKLPERVTA--LEGYQIGQVACGLNHTLA 4200

Query: 845  QTETGK-VFTWGRADYGQLG----RTLESPE------GWKPKKQAS-------------- 949
             +  G  V+ +G  DYG+LG        SP+      G   KK A               
Sbjct: 4201 VSADGSMVWAFGDGDYGKLGLGNSTAKSSPQKIDVLCGIGIKKVACGTQFSVALTKDGHV 4260

Query: 950  ---------SLPCSRPA-RSVPSSLPCLTGA--TEVSCGSEHNLAVV-GGTCYSWGWNEH 1090
                      LP  R    + P  +P L G    +V+ G+EH LA+   G  Y+WG N  
Sbjct: 4261 YTFGQDRLIGLPEGRARNHNRPQQIPVLAGVIIEDVAVGAEHTLALASNGDVYAWGSNSE 4320

Query: 1091 GMCGDGTEANVWTPKPVQALRSSSGLRLGCGAGHS 1195
            G  G G   +V  P  V  L+  +  ++  G  HS
Sbjct: 4321 GQLGLGHTNHVREPTLVTGLQGKNVRQISAGRCHS 4355



 Score = 91.3 bits (225), Expect = 2e-18
 Identities = 77/281 (27%), Positives = 121/281 (43%), Gaps = 6/281 (2%)
 Frame = +2

Query: 56   LFAWGANSYGQLGLGHKEDVLLPQQLSEFCKPGCVKRITGGGGHSAIVTDQGSLFVCGLN 235
            +F+WG   YG+LG G+      P+ +    +   V  ++ G  HSA VT+ G L+  G  
Sbjct: 479  VFSWGDGDYGKLGHGNSSTQKYPKLIQGPLQGKVVVCVSAGYRHSAAVTEDGELYTWGEG 538

Query: 236  KDGQLGLGHTEDVLYFTLCKSLLGCPIQQVACGWDFTIILTKNGQ-VLSCGSNSFGQLGV 412
              G+LG G +      TL K +    + +V+CG   TI L+K+G+ V S G    G+LG 
Sbjct: 539  DFGRLGHGDSNSRNIPTLVKDISN--VGEVSCGSSHTIALSKDGRTVWSFGGGDNGKLG- 595

Query: 413  PHG-PRRCVVPQAIE-VQREKVVSIXXXXXXXXXXXXSGLVFQWGTGLASSGRRLCPGQT 586
             HG   R   P+ IE +Q   +  +            +G V+ WG G        C    
Sbjct: 596  -HGDTNRVYKPKVIEALQGMFIRKVCAGSQSSLALTSTGQVYAWGCGACLG----CGSSE 650

Query: 587  LPLFLTAKEPSKVTGLENSQAVCVLAGSGHSASLTDAGELYVWGSNKHGQLASQAAFLPL 766
                 TA  P  +  L  ++ V V  G  H  +L+   E+Y WG+N  GQ     +  P+
Sbjct: 651  ----ATALRPKLIEELAATRIVDVSIGDSHCLALSHDNEVYAWGNNSMGQCGQGNSTGPI 706

Query: 767  PQKIEAHRFQNEKVAAVWSGWTHLVAQT---ETGKVFTWGR 880
             +  +        +  + +G +H +A T      +V  W R
Sbjct: 707  TKPKKVSGLDGIAIQQISAGTSHSLAWTALPRDRQVVAWHR 747



 Score = 82.4 bits (202), Expect = 8e-16
 Identities = 77/297 (25%), Positives = 128/297 (43%), Gaps = 4/297 (1%)
 Frame = +2

Query: 62   AWGANSYGQLGLGHKEDVLLPQQLSEFCKPGCVKRIT---GGGGHSAIVTDQGSLFVCGL 232
            A G  SYG+LGLG   +    ++L+ F     +K+++   G  GH+   T +G +F  G 
Sbjct: 426  ACGKGSYGRLGLGDSNNQSTLKKLT-FEPHRSIKKVSSSKGSDGHTLAFTTEGEVFSWGD 484

Query: 233  NKDGQLGLGHTEDVLYFTLCKS-LLGCPIQQVACGWDFTIILTKNGQVLSCGSNSFGQLG 409
               G+LG G++    Y  L +  L G  +  V+ G+  +  +T++G++ + G   FG+LG
Sbjct: 485  GDYGKLGHGNSSTQKYPKLIQGPLQGKVVVCVSAGYRHSAAVTEDGELYTWGEGDFGRLG 544

Query: 410  VPHGPRRCVVPQAIEVQREKVVSIXXXXXXXXXXXXSGLVFQWGTGLASSGRRLCPGQTL 589
                  R +     ++     VS               +   W  G   +G+ L  G T 
Sbjct: 545  HGDSNSRNIPTLVKDISNVGEVSCGSSHTIALSKDGRTV---WSFGGGDNGK-LGHGDTN 600

Query: 590  PLFLTAKEPSKVTGLENSQAVCVLAGSGHSASLTDAGELYVWGSNKHGQLASQAAFLPLP 769
             ++    +P  +  L+      V AGS  S +LT  G++Y WG        S  A    P
Sbjct: 601  RVY----KPKVIEALQGMFIRKVCAGSQSSLALTSTGQVYAWGCGACLGCGSSEATALRP 656

Query: 770  QKIEAHRFQNEKVAAVWSGWTHLVAQTETGKVFTWGRADYGQLGRTLESPEGWKPKK 940
            + IE       ++  V  G +H +A +   +V+ WG    GQ G+   +    KPKK
Sbjct: 657  KLIE--ELAATRIVDVSIGDSHCLALSHDNEVYAWGNNSMGQCGQGNSTGPITKPKK 711



 Score = 79.7 bits (195), Expect = 5e-15
 Identities = 92/384 (23%), Positives = 152/384 (39%), Gaps = 64/384 (16%)
 Frame = +2

Query: 56   LFAWGANSYGQLGLGHKEDVLLPQQLSEFCKPGCVKRITGGGGHSAIVTDQGSLFVCGLN 235
            ++ WGA  +GQL    + +V++P     F +    +++  G   + ++   G++  CG  
Sbjct: 3999 VYLWGAGRHGQLAEAGR-NVMVPAAAPSFSQ---AQQVICGQNCTFVIQANGTVLACGEG 4054

Query: 236  KDGQLGLGHTEDVLYFTLCKSLLGCPIQQV--ACGWD-FTIILTKNGQVLSCGSNSFGQL 406
              G+LG G+++D+   T+  +L G  + Q+  +CG D  ++ LT++G+V S G   +G+L
Sbjct: 4055 SYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSDGHSMALTESGEVFSWGDGDYGKL 4114

Query: 407  GVPHGPRRCVVPQAIEVQREKVVSIXXXXXXXXXXXXSGLVFQWGTGLASSGRRLCPGQT 586
            G  +  R+    Q   +Q E+VV +             G +F +G G      RL  G T
Sbjct: 4115 GHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNG---DYGRLGLGNT 4171

Query: 587  LPLFLTAKEPSKVTGLENSQAVCVLAGSGHSASLT-DAGELYVWGSNKHGQLA-SQAAFL 760
                   K P +VT LE  Q   V  G  H+ +++ D   ++ +G   +G+L    +   
Sbjct: 4172 S----NKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNSTAK 4227

Query: 761  PLPQKIEA--------------------------------------------HRFQNEKV 808
              PQKI+                                             +R Q   V
Sbjct: 4228 SSPQKIDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGLPEGRARNHNRPQQIPV 4287

Query: 809  AA------VWSGWTHLVAQTETGKVFTWGRADYGQLG---------RTLESPEGWKPKKQ 943
             A      V  G  H +A    G V+ WG    GQLG          TL +    K  +Q
Sbjct: 4288 LAGVIIEDVAVGAEHTLALASNGDVYAWGSNSEGQLGLGHTNHVREPTLVTGLQGKNVRQ 4347

Query: 944  ASSLPCSRPARSVPSSLPCLTGAT 1015
             S+  C   A + P   P   G +
Sbjct: 4348 ISAGRCHSAAWTAPPVPPRAPGVS 4371



 Score = 60.8 bits (146), Expect = 3e-09
 Identities = 68/285 (23%), Positives = 113/285 (39%), Gaps = 42/285 (14%)
 Frame = +2

Query: 425  RRCVVPQAIEVQREKVVSIXXXXXXXXXXXXSGLVFQWGTGLASSGRRLCPGQTLPLFLT 604
            R C  P +I+     +VS                V+ WG+   +S  +L  G    +   
Sbjct: 352  RTCASPDSIQTGDAPIVSETCE------------VYVWGS---NSSHQLVEGTQEKILQP 396

Query: 605  AKEPSKVTGLENSQAVCVLAGSGHSASLTDAGELYVWGSNKHGQLA-----SQAAFLPLP 769
               PS       S A  + AG   +  ++  G +   G   +G+L      +Q+    L 
Sbjct: 397  KLAPSF------SDAQTIEAGQYCTFVISTDGSVRACGKGSYGRLGLGDSNNQSTLKKLT 450

Query: 770  QKIEAHRFQNEKVAAVWSGWTHLVAQTETGKVFTWGRADYGQLGR----TLESPEGWKPK 937
               E HR   +KV++      H +A T  G+VF+WG  DYG+LG     T + P+  +  
Sbjct: 451  --FEPHR-SIKKVSSSKGSDGHTLAFTTEGEVFSWGDGDYGKLGHGNSSTQKYPKLIQGP 507

Query: 938  KQASSLPC-------------------------------SRPARSVPSSLPCLTGATEVS 1024
             Q   + C                                  +R++P+ +  ++   EVS
Sbjct: 508  LQGKVVVCVSAGYRHSAAVTEDGELYTWGEGDFGRLGHGDSNSRNIPTLVKDISNVGEVS 567

Query: 1025 CGSEHNLAVV--GGTCYSWGWNEHGMCGDGTEANVWTPKPVQALR 1153
            CGS H +A+   G T +S+G  ++G  G G    V+ PK ++AL+
Sbjct: 568  CGSSHTIALSKDGRTVWSFGGGDNGKLGHGDTNRVYKPKVIEALQ 612


  Database: RefSeq49_HP.fasta
    Posted date:  Oct 17, 2011  1:42 PM
  Number of letters in database: 18,297,164
  Number of sequences in database:  32,964
  
Lambda     K      H
   0.318    0.134    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 32964
Number of Hits to DB: 58,171,623
Number of extensions: 1842107
Number of successful extensions: 7661
Number of sequences better than 1.0e-05: 30
Number of HSP's gapped: 7189
Number of HSP's successfully gapped: 116
Length of query: 421
Length of database: 18,297,164
Length adjustment: 105
Effective length of query: 316
Effective length of database: 14,835,944
Effective search space: 4688158304
Effective search space used: 4688158304
Neighboring words threshold: 12
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 35 (18.1 bits)

BLASTX 2.2.24 [Aug-08-2010]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= 20110601C-004015
         (1263 letters)

Database: RefSeq49_MP.fasta 
           30,036 sequences; 15,617,559 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

Alignment   gi|NP_038817.1| secretion-regulating guanine nucleotide exchang...   625   e-179
Alignment   gi|NP_082981.3| hect domain and RLD 3 [Mus musculus].                133   3e-31
Alignment   gi|NP_084390.1| probable E3 ubiquitin-protein ligase HERC4 isof...   129   6e-30
Alignment   gi|NP_080377.2| probable E3 ubiquitin-protein ligase HERC4 isof...   129   6e-30
Alignment   gi|NP_034548.2| E3 ubiquitin-protein ligase HERC2 [Mus musculus].    124   2e-28
Alignment   gi|NP_001171424.1| X-linked retinitis pigmentosa GTPase regulat...   113   4e-25
Alignment   gi|NP_001171422.1| X-linked retinitis pigmentosa GTPase regulat...   113   4e-25
Alignment   gi|NP_001171421.1| X-linked retinitis pigmentosa GTPase regulat...   113   4e-25
Alignment   gi|NP_035415.1| X-linked retinitis pigmentosa GTPase regulator ...   113   4e-25
Alignment   gi|NP_001171423.1| X-linked retinitis pigmentosa GTPase regulat...   110   2e-24

>ref|NP_038817.1| secretion-regulating guanine nucleotide exchange factor [Mus
            musculus].
          Length = 464

 Score =  625 bits (1611), Expect = e-179
 Identities = 297/382 (77%), Positives = 322/382 (84%), Gaps = 2/382 (0%)
 Frame = +2

Query: 56   LFAWGANSYGQLGLGHKEDVLLPQQLSEFCKPGCVKRITGGGGHSAIVTDQGSLFVCGLN 235
            LFAWGANSYGQLGLGHKEDV LPQQLS+FC+ GC+K +TGGGGHSA+VTD G LFVCGLN
Sbjct: 17   LFAWGANSYGQLGLGHKEDVFLPQQLSDFCQAGCIKSVTGGGGHSAVVTDGGDLFVCGLN 76

Query: 236  KDGQLGLGHTEDVLYFTLCKSLLGCPIQQVACGWDFTIILTKNGQVLSCGSNSFGQLGVP 415
            KDGQLGLGHTE+VL FT+CK L GCPI+QVACGWDFTI+LT+ GQVLSCGSN+FGQLGVP
Sbjct: 77   KDGQLGLGHTEEVLRFTICKPLRGCPIRQVACGWDFTIMLTEKGQVLSCGSNAFGQLGVP 136

Query: 416  HGPRRCVVPQAIEVQREKVVSIXXXXXXXXXXXXSGLVFQWGTGLASSGRRLCPGQTLPL 595
            HGPR+CVVPQAIE  REKVV +            +G VFQWGTGLASSGRRLCPGQ LPL
Sbjct: 137  HGPRKCVVPQAIECLREKVVCVAAGLRHALATTATGSVFQWGTGLASSGRRLCPGQNLPL 196

Query: 596  FLTAKEPSKVTGLENSQAVCVLAGSGHSASLTDAGELYVWGSNKHGQLASQAAFLPLPQK 775
            FLTAKEPS+VTGLENS AVC +AGS HSASLTD GELYVWG NKHGQLAS+A FLPLPQ+
Sbjct: 197  FLTAKEPSRVTGLENSTAVCAVAGSDHSASLTDTGELYVWGRNKHGQLASRAVFLPLPQR 256

Query: 776  IEAHRFQNEKVAAVWSGWTHLVAQTETGKVFTWGRADYGQLGRTLESPEGWKPKKQASSL 955
            IEAH FQ+EKV AVWSGWTHLVA+TETGKVFTWGRADYGQLGR LE PE  KP +Q SSL
Sbjct: 257  IEAHYFQDEKVTAVWSGWTHLVAKTETGKVFTWGRADYGQLGRRLEPPEAQKPVEQDSSL 316

Query: 956  PCSRPARSVPSSLPCLTGATEVSCGSEHNLAVVGGTCYSWGWNEHGMCGDGTEANVWTPK 1135
                P  SVPS L CLTGATE+SCGSEHNLAV+   C SWGWNEHGMCGDGTE+NVWTP 
Sbjct: 317  AFQGPQNSVPSPLHCLTGATEISCGSEHNLAVIRDKCCSWGWNEHGMCGDGTESNVWTPT 376

Query: 1136 PVQALRSSSG--LRLGCGAGHS 1195
            PVQAL  S    L +GCGAGHS
Sbjct: 377  PVQALPPSPSRLLLVGCGAGHS 398


>ref|NP_082981.3| hect domain and RLD 3 [Mus musculus].
          Length = 1050

 Score =  133 bits (335), Expect = 3e-31
 Identities = 104/368 (28%), Positives = 162/368 (44%), Gaps = 5/368 (1%)
 Frame = +2

Query: 56   LFAWGANSYGQLGLGHK-EDVLLPQQLSEFCKPGCVKRITGGGGHSAIVTDQGSLFVCGL 232
            +  WG  S GQ G+    + ++   Q+  F     +K +  GG HS  + + G ++ CG+
Sbjct: 1    MLCWGYWSLGQPGISSNLQGIVAEPQVCRFVSDRSIKEVACGGNHSVFLLEDGEVYTCGV 60

Query: 233  NKDGQLGLGHTEDVLYFTLCKSLLGCPIQQVACGWDFTIILTKNGQVLSCGSNSFGQLGV 412
            N  GQ  LGH  +        +L    I  VACG   ++ L+  GQ+ S G+ S GQLG+
Sbjct: 61   NTKGQ--LGHEREGNKPEQIGALADQHIIHVACGESHSLALSDRGQLFSWGAGSDGQLGL 118

Query: 413  PHGPRRCVVPQAIE-VQREKVVSIXXXXXXXXXXXXSGLVFQWGTGLASSGRRLCPGQTL 589
                    VP+ I+ + ++ ++ +             G  F WG    +S  +L  G+  
Sbjct: 119  MTTEDSVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWG---KNSHGQLGLGKEF 175

Query: 590  PLFLTAKEPSKVTGLENSQAVCVLAGSGHSASLTDAGELYVWGSNKHGQLA-SQAAFLPL 766
            P   +   P +V  LE      V AG  HS +L+ +G ++ WG N  GQL  S       
Sbjct: 176  P---SQTSPQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEKDRES 232

Query: 767  PQKIEAHRFQNEKVAAVWSGWTHLVAQTETGKVFTWGRADYGQLGRTLESPEGWKPKKQA 946
            P  ++  R Q  KV  +  G  H    T++G VFT+G    GQLG    + E   P++  
Sbjct: 233  PCHVKLLRTQ--KVVYISCGEEHTAVLTKSGGVFTFGAGSCGQLGHDSVNDE-VNPRRVL 289

Query: 947  SSLPCSRPARSVPSSLPCLTGATEVSCGSEHNLAVV--GGTCYSWGWNEHGMCGDGTEAN 1120
              +                +  T+++CG +H LA+V   G  Y++G    G  G G   N
Sbjct: 290  ELMG---------------SEVTQIACGRQHTLALVPSSGLIYAFGCGAKGQLGTGHTCN 334

Query: 1121 VWTPKPVQ 1144
            V  P PV+
Sbjct: 335  VKCPSPVK 342



 Score = 94.4 bits (233), Expect = 2e-19
 Identities = 77/307 (25%), Positives = 125/307 (40%), Gaps = 4/307 (1%)
 Frame = +2

Query: 287  LCKSLLGCPIQQVACGWDFTIILTKNGQVLSCGSNSFGQLGVPHGPRRCVVPQAIEVQRE 466
            +C+ +    I++VACG + ++ L ++G+V +CG N+ GQLG  H        Q   +  +
Sbjct: 27   VCRFVSDRSIKEVACGGNHSVFLLEDGEVYTCGVNTKGQLG--HEREGNKPEQIGALADQ 84

Query: 467  KVVSIXXXXXXXXXXXXSGLVFQWGTGLASSGRRLCPGQTLPLFLTAKE---PSKVTGLE 637
             ++ +             G +F WG G  S G+       L L  T      P  +  L 
Sbjct: 85   HIIHVACGESHSLALSDRGQLFSWGAG--SDGQ-------LGLMTTEDSVAVPRLIQKLN 135

Query: 638  NSQAVCVLAGSGHSASLTDAGELYVWGSNKHGQLASQAAFLPLPQKIEAHRFQNEKVAAV 817
                + V  G+ H  +L   G+ + WG N HGQL     F            +   +A V
Sbjct: 136  QQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQTSPQRVRSLEGIPLAQV 195

Query: 818  WSGWTHLVAQTETGKVFTWGRADYGQLGRTLESPEGWKPKKQASSLPCSRPARSVPSSLP 997
             +G  H  A + +G VF WG  + GQLG + E     K ++    +   R  + V     
Sbjct: 196  AAGGAHSFALSLSGAVFGWGMNNAGQLGLSDE-----KDRESPCHVKLLRTQKVV----- 245

Query: 998  CLTGATEVSCGSEHNLAVV-GGTCYSWGWNEHGMCGDGTEANVWTPKPVQALRSSSGLRL 1174
                   +SCG EH   +   G  +++G    G  G  +  +   P+ V  L  S   ++
Sbjct: 246  ------YISCGEEHTAVLTKSGGVFTFGAGSCGQLGHDSVNDEVNPRRVLELMGSEVTQI 299

Query: 1175 GCGAGHS 1195
             CG  H+
Sbjct: 300  ACGRQHT 306



 Score = 82.4 bits (202), Expect = 7e-16
 Identities = 70/247 (28%), Positives = 102/247 (41%), Gaps = 3/247 (1%)
 Frame = +2

Query: 56  LFAWGANSYGQLGLGHKEDVLLPQQLSEFCKPGCVKRITGGGGHSAIVTDQGSLFVCGLN 235
           LF+WGA S GQLGL   ED +   +L +      + +++ G  H   +   G  F  G N
Sbjct: 105 LFSWGAGSDGQLGLMTTEDSVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKN 164

Query: 236 KDGQLGLG-HTEDVLYFTLCKSLLGCPIQQVACGWDFTIILTKNGQVLSCGSNSFGQLGV 412
             GQLGLG            +SL G P+ QVA G   +  L+ +G V   G N+ GQLG+
Sbjct: 165 SHGQLGLGKEFPSQTSPQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGL 224

Query: 413 PHGPRRCVVPQAIEVQREKVVSIXXXXXXXXXXXXSGLVFQWGTGLASSGRRLCPGQTLP 592
                R        ++ +KVV I            SG VF +G G        C      
Sbjct: 225 SDEKDRESPCHVKLLRTQKVVYISCGEEHTAVLTKSGGVFTFGAG-------SCGQLGHD 277

Query: 593 LFLTAKEPSKVTGLENSQAVCVLAGSGHSASLT-DAGELYVWGSNKHGQLAS-QAAFLPL 766
                  P +V  L  S+   +  G  H+ +L   +G +Y +G    GQL +     +  
Sbjct: 278 SVNDEVNPRRVLELMGSEVTQIACGRQHTLALVPSSGLIYAFGCGAKGQLGTGHTCNVKC 337

Query: 767 PQKIEAH 787
           P  ++ H
Sbjct: 338 PSPVKGH 344



 Score = 66.6 bits (161), Expect = 4e-11
 Identities = 41/123 (33%), Positives = 62/123 (50%), Gaps = 1/123 (0%)
 Frame = +2

Query: 53  ALFAWGANSYGQLGLGHKEDVLLPQQLSEFCKPGCVKRITGGGGHSAIVTDQGSLFVCGL 232
           A+F WG N+ GQLGL  ++D   P  + +  +   V  I+ G  H+A++T  G +F  G 
Sbjct: 210 AVFGWGMNNAGQLGLSDEKDRESPCHV-KLLRTQKVVYISCGEEHTAVLTKSGGVFTFGA 268

Query: 233 NKDGQLGLGHTEDVLYFTLCKSLLGCPIQQVACGWDFTIILT-KNGQVLSCGSNSFGQLG 409
              GQLG     D +       L+G  + Q+ACG   T+ L   +G + + G  + GQLG
Sbjct: 269 GSCGQLGHDSVNDEVNPRRVLELMGSEVTQIACGRQHTLALVPSSGLIYAFGCGAKGQLG 328

Query: 410 VPH 418
             H
Sbjct: 329 TGH 331


>ref|NP_084390.1| probable E3 ubiquitin-protein ligase HERC4 isoform 1 [Mus musculus].
          Length = 1057

 Score =  129 bits (323), Expect = 6e-30
 Identities = 115/371 (30%), Positives = 171/371 (46%), Gaps = 8/371 (2%)
 Frame = +2

Query: 56   LFAWGANSYGQLGLGH-KEDVLLPQQLSEFCKPGCVKRITGGGGHSAIVTDQGSLFVCGL 232
            +  WG  SYGQLGLG   E+++L  + S+F     V+ +  G  H+  V D G+++ CG 
Sbjct: 1    MLCWGNASYGQLGLGGIDEEIVLEPRRSDFFVNKKVRDVGCGLRHTVFVLDDGTVYTCGC 60

Query: 233  NKDGQLGLGHTEDVLYFTLCKSLLGCPIQQVACGWDFTIILTKNGQVLSCGSNSFGQLGV 412
            N  GQ  LGH +         +L    I  VACG   T+ L   GQV + G +S GQLG+
Sbjct: 61   NDLGQ--LGHEKSRKKPEQVVALDAQNIVAVACGEAHTLALNDKGQVYAWGLDSDGQLGL 118

Query: 413  PHGPRRCV-VPQAIEVQRE-KVVSIXXXXXXXXXXXXSGLVFQWGTG-LASSGRRL-CPG 580
              G   C+ VP+ I+   + ++V +            +  VF WG       G  + C  
Sbjct: 119  -QGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGIDCQK 177

Query: 581  QTLPLFLTAKEPSKVTGLENSQAVCVLAGSGHSASLTDAGELYVWGSNKHGQLA-SQAAF 757
            QT P  +       + G+   Q   V AG  HS  LT +G ++ WG NK GQL  +    
Sbjct: 178  QTSPQLI-----KSLLGIPFMQ---VAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDEND 229

Query: 758  LPLPQKIEAHRFQNEKVAAVWSGWTHLVAQTETGKVFTWGRADYGQLGRTLESPEGWKPK 937
              +P  +++ R  ++K+  +  G  H  A T+ G VFT+G   YGQLG    S E   P+
Sbjct: 230  RYVPNLLKSLR--SQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHE-INPR 286

Query: 938  KQASSLPCSRPARSVPSSLPCLTGATEVSCGSEHNLAVV--GGTCYSWGWNEHGMCGDGT 1111
            K    +                +  T+V+CG +H  A V   G  YS+G   +G  G G+
Sbjct: 287  KVFELMG---------------SIVTQVACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGS 331

Query: 1112 EANVWTPKPVQ 1144
             +N  +P  V+
Sbjct: 332  TSNRKSPFTVK 342



 Score = 89.0 bits (219), Expect = 7e-18
 Identities = 54/199 (27%), Positives = 98/199 (49%), Gaps = 3/199 (1%)
 Frame = +2

Query: 608  KEPSKVTGLENSQAVCVLAGSGHSASLTDAGELYVWGSNKHGQLASQAA--FLPLPQKIE 781
            K+P +V  L+    V V  G  H+ +L D G++Y WG +  GQL  Q +   + +P+ I+
Sbjct: 73   KKPEQVVALDAQNIVAVACGEAHTLALNDKGQVYAWGLDSDGQLGLQGSEECIRVPRNIK 132

Query: 782  AHRFQNEKVAAVWSGWTHLVAQTETGKVFTWGRADYGQLGRTLESPEGWKPKKQASSLPC 961
            +    + ++  V  G+ H +A ++  +VF WG+  YGQLG  ++  +   P+   S L  
Sbjct: 133  S--LSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGIDCQKQTSPQLIKSLL-- 188

Query: 962  SRPARSVPSSLPCLTGATEVSCGSEHNLAV-VGGTCYSWGWNEHGMCGDGTEANVWTPKP 1138
                      +P +    +V+ G  H+  + + G  + WG N+ G  G   E + + P  
Sbjct: 189  ---------GIPFM----QVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNL 235

Query: 1139 VQALRSSSGLRLGCGAGHS 1195
            +++LRS   + + CG  H+
Sbjct: 236  LKSLRSQKIVYICCGEDHT 254



 Score = 65.5 bits (158), Expect = 9e-11
 Identities = 41/120 (34%), Positives = 58/120 (48%), Gaps = 1/120 (0%)
 Frame = +2

Query: 53  ALFAWGANSYGQLGLGHKEDVLLPQQLSEFCKPGCVKRITGGGGHSAIVTDQGSLFVCGL 232
           A+F WG N +GQLGL  + D  +P  L    +   +  I  G  H+A +T +G +F  G 
Sbjct: 210 AIFGWGRNKFGQLGLNDENDRYVPNLLKSL-RSQKIVYICCGEDHTAALTKEGGVFTFGA 268

Query: 233 NKDGQLGLGHTEDVLYFTLCKSLLGCPIQQVACGWDFT-IILTKNGQVLSCGSNSFGQLG 409
              GQLG   T   +       L+G  + QVACG   T   +  +G++ S G    GQLG
Sbjct: 269 GGYGQLGHNSTSHEINPRKVFELMGSIVTQVACGRQHTSAFVPSSGRIYSFGLGGNGQLG 328


>ref|NP_080377.2| probable E3 ubiquitin-protein ligase HERC4 isoform 2 [Mus musculus].
          Length = 1049

 Score =  129 bits (323), Expect = 6e-30
 Identities = 115/371 (30%), Positives = 171/371 (46%), Gaps = 8/371 (2%)
 Frame = +2

Query: 56   LFAWGANSYGQLGLGH-KEDVLLPQQLSEFCKPGCVKRITGGGGHSAIVTDQGSLFVCGL 232
            +  WG  SYGQLGLG   E+++L  + S+F     V+ +  G  H+  V D G+++ CG 
Sbjct: 1    MLCWGNASYGQLGLGGIDEEIVLEPRRSDFFVNKKVRDVGCGLRHTVFVLDDGTVYTCGC 60

Query: 233  NKDGQLGLGHTEDVLYFTLCKSLLGCPIQQVACGWDFTIILTKNGQVLSCGSNSFGQLGV 412
            N  GQ  LGH +         +L    I  VACG   T+ L   GQV + G +S GQLG+
Sbjct: 61   NDLGQ--LGHEKSRKKPEQVVALDAQNIVAVACGEAHTLALNDKGQVYAWGLDSDGQLGL 118

Query: 413  PHGPRRCV-VPQAIEVQRE-KVVSIXXXXXXXXXXXXSGLVFQWGTG-LASSGRRL-CPG 580
              G   C+ VP+ I+   + ++V +            +  VF WG       G  + C  
Sbjct: 119  -QGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGIDCQK 177

Query: 581  QTLPLFLTAKEPSKVTGLENSQAVCVLAGSGHSASLTDAGELYVWGSNKHGQLA-SQAAF 757
            QT P  +       + G+   Q   V AG  HS  LT +G ++ WG NK GQL  +    
Sbjct: 178  QTSPQLI-----KSLLGIPFMQ---VAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDEND 229

Query: 758  LPLPQKIEAHRFQNEKVAAVWSGWTHLVAQTETGKVFTWGRADYGQLGRTLESPEGWKPK 937
              +P  +++ R  ++K+  +  G  H  A T+ G VFT+G   YGQLG    S E   P+
Sbjct: 230  RYVPNLLKSLR--SQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHE-INPR 286

Query: 938  KQASSLPCSRPARSVPSSLPCLTGATEVSCGSEHNLAVV--GGTCYSWGWNEHGMCGDGT 1111
            K    +                +  T+V+CG +H  A V   G  YS+G   +G  G G+
Sbjct: 287  KVFELMG---------------SIVTQVACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGS 331

Query: 1112 EANVWTPKPVQ 1144
             +N  +P  V+
Sbjct: 332  TSNRKSPFTVK 342



 Score = 89.0 bits (219), Expect = 7e-18
 Identities = 54/199 (27%), Positives = 98/199 (49%), Gaps = 3/199 (1%)
 Frame = +2

Query: 608  KEPSKVTGLENSQAVCVLAGSGHSASLTDAGELYVWGSNKHGQLASQAA--FLPLPQKIE 781
            K+P +V  L+    V V  G  H+ +L D G++Y WG +  GQL  Q +   + +P+ I+
Sbjct: 73   KKPEQVVALDAQNIVAVACGEAHTLALNDKGQVYAWGLDSDGQLGLQGSEECIRVPRNIK 132

Query: 782  AHRFQNEKVAAVWSGWTHLVAQTETGKVFTWGRADYGQLGRTLESPEGWKPKKQASSLPC 961
            +    + ++  V  G+ H +A ++  +VF WG+  YGQLG  ++  +   P+   S L  
Sbjct: 133  S--LSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGIDCQKQTSPQLIKSLL-- 188

Query: 962  SRPARSVPSSLPCLTGATEVSCGSEHNLAV-VGGTCYSWGWNEHGMCGDGTEANVWTPKP 1138
                      +P +    +V+ G  H+  + + G  + WG N+ G  G   E + + P  
Sbjct: 189  ---------GIPFM----QVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNL 235

Query: 1139 VQALRSSSGLRLGCGAGHS 1195
            +++LRS   + + CG  H+
Sbjct: 236  LKSLRSQKIVYICCGEDHT 254



 Score = 65.5 bits (158), Expect = 9e-11
 Identities = 41/120 (34%), Positives = 58/120 (48%), Gaps = 1/120 (0%)
 Frame = +2

Query: 53  ALFAWGANSYGQLGLGHKEDVLLPQQLSEFCKPGCVKRITGGGGHSAIVTDQGSLFVCGL 232
           A+F WG N +GQLGL  + D  +P  L    +   +  I  G  H+A +T +G +F  G 
Sbjct: 210 AIFGWGRNKFGQLGLNDENDRYVPNLLKSL-RSQKIVYICCGEDHTAALTKEGGVFTFGA 268

Query: 233 NKDGQLGLGHTEDVLYFTLCKSLLGCPIQQVACGWDFT-IILTKNGQVLSCGSNSFGQLG 409
              GQLG   T   +       L+G  + QVACG   T   +  +G++ S G    GQLG
Sbjct: 269 GGYGQLGHNSTSHEINPRKVFELMGSIVTQVACGRQHTSAFVPSSGRIYSFGLGGNGQLG 328


>ref|NP_034548.2| E3 ubiquitin-protein ligase HERC2 [Mus musculus].
          Length = 4836

 Score =  124 bits (310), Expect = 2e-28
 Identities = 114/390 (29%), Positives = 171/390 (43%), Gaps = 10/390 (2%)
 Frame = +2

Query: 56   LFAWGANSYGQLG--LGHKEDVLLPQQLSEFCKPGCVKRITGGGGHSAIVTDQGSLFVCG 229
            ++ WG N  GQLG   G K  V  P +     +P    ++ GG      VT  G L+  G
Sbjct: 3956 IYGWGHNHRGQLGGIEGAKVKVPTPCEALATLRP---VQLIGGEQTLFAVTADGKLYATG 4012

Query: 230  LNKDGQLGLGHTEDVLYFTLCKSLLGCPIQQVAC--GWDFTIILTKNGQVLSCGSNSFGQ 403
                G+LG+G TE V   TL +S+    I++VA   G    + L+  G+V S G    G+
Sbjct: 4013 YGAGGRLGIGGTESVSTPTLLESIQHVFIKKVAVNSGGKHCLALSSEGEVYSWGEAEDGK 4072

Query: 404  LGVPHGPRR-CVVPQAIEVQRE-KVVSIXXXXXXXXXXXXSGLVFQWGTG-LASSGRRLC 574
            LG  HG R  C  P+ IE  R  +VV +            +G ++ WG G     G    
Sbjct: 4073 LG--HGNRSPCDRPRVIESLRGIEVVDVAAGGAHSACVTAAGDLYTWGKGRYGRLGHSDS 4130

Query: 575  PGQTLPLFLTAKEPSKVTGLENSQAVCVLAGSGHSASL--TDAGELYVWGSNKHGQLASQ 748
              Q         +P  V  L+  + + +  GSG + +L  TD   ++ WG   +G+L   
Sbjct: 4131 EDQL--------KPKLVEALQGHRVIDIACGSGDAQTLCLTDDDTVWSWGDGDYGKLGRG 4182

Query: 749  AAF-LPLPQKIEAHRFQNEKVAAVWSGWTHLVAQTETGKVFTWGRADYGQLGRTLESPEG 925
             +    +P KI++       V  V  G    VA T++G V+TWG+ DY +LG    S + 
Sbjct: 4183 GSDGCKVPMKIDS--LTGLGVVKVECGSQFSVALTKSGAVYTWGKGDYHRLGHG--SDDH 4238

Query: 926  WKPKKQASSLPCSRPARSVPSSLPCLTGATEVSCGSEHNLAVVGGTCYSWGWNEHGMCGD 1105
             +  +Q   L   +       SL C+       C +E       G  Y+WG N+ G  GD
Sbjct: 4239 VRRPRQVQGLQGKKVIAIATGSLHCV-------CCTED------GEVYTWGDNDEGQLGD 4285

Query: 1106 GTEANVWTPKPVQALRSSSGLRLGCGAGHS 1195
            GT   +  P+ V AL+     R+ CG+ H+
Sbjct: 4286 GTTNAIQRPRLVAALQGKKVNRVACGSAHT 4315



 Score =  119 bits (297), Expect = 7e-27
 Identities = 117/398 (29%), Positives = 167/398 (41%), Gaps = 16/398 (4%)
 Frame = +2

Query: 50   TALFAWGANSYGQLGLGHKEDVLLPQQLSEFCKPGCVKRITGGGGHSAIVTDQGSLFVCG 229
            T +F WG N   QLG G K   +     SE      V ++ GG      VT +G ++ CG
Sbjct: 2960 TKVFVWGLNDKDQLG-GLKGSKIKVPSFSETLSALNVVQVAGGSKSLFAVTVEGKVYSCG 3018

Query: 230  LNKDGQLGLGHTEDVLYFTL-CKSLLGCPIQQVAC--GWDFTIILTKNGQVLSCGSNSFG 400
               +G+LGLG +   +       +L    +++VA   G      LT +G+V S G    G
Sbjct: 3019 EATNGRLGLGMSSGTVPIPRQITALSSYVVKKVAVHSGGRHATALTVDGKVFSWGEGDDG 3078

Query: 401  QLGVPHGPR-RCVVPQAIEVQREKVV-SIXXXXXXXXXXXXSGLVFQWGTGLASSGRRLC 574
            +LG  H  R  C  P+ IE  + K +  I            SG ++ WG G      RL 
Sbjct: 3079 KLG--HFSRMNCDKPRLIEALKTKRIRDIACGSSHSAALTSSGELYTWGLGEYG---RLG 3133

Query: 575  PGQTLPLFLTAKEPSKVTGLENSQAVCVLAGS--GHSASLTDAGELYVWGSNKHGQLASQ 748
             G       T  +P  V  L   + + V  GS    + +LTD G ++ WG    G+L   
Sbjct: 3134 HGDNT----TQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFSWGDGDFGKLGRG 3189

Query: 749  AAF-LPLPQKIEAHRFQNEKVAAVWSGWTHLVAQTETGKVFTWGRADYGQLG-------R 904
             +    +PQ IE  R   + V  +  G    +A T++G V+TWG+ DY +LG       R
Sbjct: 3190 GSEGCNIPQNIE--RLNGQGVCQIECGAQFSLALTKSGVVWTWGKGDYFRLGHGSDVHVR 3247

Query: 905  TLESPEGWKPKKQASSLPCSRPARSVPSSLPCLTGATEVSCGSEHNLAVV-GGTCYSWGW 1081
              +  EG + KK                          V+ G+ H LAV   G  Y+WG 
Sbjct: 3248 KPQVVEGLRGKK-----------------------IVHVAVGALHCLAVTDSGQVYAWGD 3284

Query: 1082 NEHGMCGDGTEANVWTPKPVQALRSSSGLRLGCGAGHS 1195
            N+HG  G+GT      P  VQ L      R+ CG+ HS
Sbjct: 3285 NDHGQQGNGTTTVNRKPTLVQGLEGQKITRVACGSSHS 3322



 Score =  112 bits (281), Expect = 5e-25
 Identities = 87/268 (32%), Positives = 126/268 (47%), Gaps = 3/268 (1%)
 Frame = +2

Query: 56   LFAWGANSYGQLGLGHKEDVLLPQQLSEFCKPGCVKRITGGGGHSAIVTDQGSLFVCGLN 235
            +F+WG    G+LG   + +   P+ L E  K   ++ I  G  HSA +T  G L+  GL 
Sbjct: 3069 VFSWGEGDDGKLGHFSRMNCDKPR-LIEALKTKRIRDIACGSSHSAALTSSGELYTWGLG 3127

Query: 236  KDGQLGLGHTEDVLYFTLCKSLLGCPIQQVACGW--DFTIILTKNGQVLSCGSNSFGQLG 409
            + G+LG G     L   + K LLG  + QVACG     T+ LT  G V S G   FG+LG
Sbjct: 3128 EYGRLGHGDNTTQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFSWGDGDFGKLG 3187

Query: 410  VPHGPRRCVVPQAIE-VQREKVVSIXXXXXXXXXXXXSGLVFQWGTGLASSGRRLCPGQT 586
               G   C +PQ IE +  + V  I            SG+V+ WG G      RL  G  
Sbjct: 3188 -RGGSEGCNIPQNIERLNGQGVCQIECGAQFSLALTKSGVVWTWGKG---DYFRLGHGSD 3243

Query: 587  LPLFLTAKEPSKVTGLENSQAVCVLAGSGHSASLTDAGELYVWGSNKHGQLASQAAFLPL 766
            + +    ++P  V GL   + V V  G+ H  ++TD+G++Y WG N HGQ  +    +  
Sbjct: 3244 VHV----RKPQVVEGLRGKKIVHVAVGALHCLAVTDSGQVYAWGDNDHGQQGNGTTTVNR 3299

Query: 767  PQKIEAHRFQNEKVAAVWSGWTHLVAQT 850
               +     + +K+  V  G +H VA T
Sbjct: 3300 KPTL-VQGLEGQKITRVACGSSHSVAWT 3326



 Score =  111 bits (278), Expect = 1e-24
 Identities = 92/348 (26%), Positives = 148/348 (42%), Gaps = 11/348 (3%)
 Frame = +2

Query: 182  GHSAIVTDQGSLFVCGLNKDGQLGLGHTEDVLYFTLCKSLLGCPIQQVACGWDFTIILTK 361
            G  +  T +  +FV GLN   QLG      +   +  ++L    + QVA G      +T 
Sbjct: 2951 GLESTATIRTKVFVWGLNDKDQLGGLKGSKIKVPSFSETLSALNVVQVAGGSKSLFAVTV 3010

Query: 362  NGQVLSCGSNSFGQLGVPHGPRRCVVPQAIEVQRE---KVVSIXXXXXXXXXXXXSGLVF 532
             G+V SCG  + G+LG+        +P+ I        K V++             G VF
Sbjct: 3011 EGKVYSCGEATNGRLGLGMSSGTVPIPRQITALSSYVVKKVAVHSGGRHATALTVDGKVF 3070

Query: 533  QWGTG----LASSGRRLCPGQTLPLFLTAKEPSKVTGLENSQAVCVLAGSGHSASLTDAG 700
             WG G    L    R  C            +P  +  L+  +   +  GS HSA+LT +G
Sbjct: 3071 SWGEGDDGKLGHFSRMNC-----------DKPRLIEALKTKRIRDIACGSSHSAALTSSG 3119

Query: 701  ELYVWGSNKHGQLASQAAFLPL-PQKIEAHRFQNEKVAAVWSGWTHLVAQTETGKVFTWG 877
            ELY WG  ++G+L        L P+ ++          A  S     +A T+ G VF+WG
Sbjct: 3120 ELYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFSWG 3179

Query: 878  RADYGQLGRTLESPEGWKPKKQASSLPCSRPARSVPSSLPCLT--GATEVSCGSEHNLAV 1051
              D+G+LGR               S  C     ++P ++  L   G  ++ CG++ +LA+
Sbjct: 3180 DGDFGKLGR-------------GGSEGC-----NIPQNIERLNGQGVCQIECGAQFSLAL 3221

Query: 1052 V-GGTCYSWGWNEHGMCGDGTEANVWTPKPVQALRSSSGLRLGCGAGH 1192
               G  ++WG  ++   G G++ +V  P+ V+ LR    + +  GA H
Sbjct: 3222 TKSGVVWTWGKGDYFRLGHGSDVHVRKPQVVEGLRGKKIVHVAVGALH 3269



 Score =  108 bits (271), Expect = 7e-24
 Identities = 91/326 (27%), Positives = 143/326 (43%), Gaps = 9/326 (2%)
 Frame = +2

Query: 242  GQLGLGHTEDVLYFTLCKSLLGCPIQQVACGWDFTIILTKNGQVLSCGSNSFGQLGVPHG 421
            G +G  +  +V+    C+ L    + QVAC     +IL++NG+V +   NS         
Sbjct: 430  GLIGWKYYANVIGPIQCEGLASLGVMQVACAEKRFLILSRNGRVYTQAYNS--------- 480

Query: 422  PRRCVVPQAIE-VQREKVVSIXXXXXXXXXXXXS--GLVFQWGTGLASSGRRLCPGQTLP 592
                + PQ ++ +    +V I            +  G V+ WG G    G RL  G T+P
Sbjct: 481  --DMLAPQLVQGLASRNIVKIAAHSDGHHYLALAATGEVYSWGCG---DGGRLGHGDTVP 535

Query: 593  LFLTAKEPSKVTGLENSQA----VCVLAGSGHSASLTDAGELYVWGSNKHGQLA-SQAAF 757
            L    +EP  ++     QA    V +  GS +SA++T  GELY WG   +G+L    +  
Sbjct: 536  L----EEPKVISAFSGKQAGKHVVHIACGSTYSAAITAEGELYTWGRGNYGRLGHGSSED 591

Query: 758  LPLPQKIEAHRFQNEKVAAVWSGWTHLVAQTETGKVFTWGRADYGQLGRTLESPEGWKPK 937
              +P  +   +       A  SG    +A TE G+V++WG  DYG+LGR     +G K  
Sbjct: 592  EAIPMLVAGLKGLKVIDVACGSGDAQTLAVTENGQVWSWGDGDYGKLGR--GGSDGCKTP 649

Query: 938  KQASSLPCSRPARSVPSSLPCLTGATEVSCGSEHNLAVV-GGTCYSWGWNEHGMCGDGTE 1114
            K    L                    +V CGS+ ++A+   G  YSWG  ++   G GTE
Sbjct: 650  KLIEKLQD--------------LDVIKVRCGSQFSIALTKDGQVYSWGKGDNQRLGHGTE 695

Query: 1115 ANVWTPKPVQALRSSSGLRLGCGAGH 1192
             +V  PK ++ L+    + +  G+ H
Sbjct: 696  EHVRYPKLLEGLQGKKVIDVAAGSTH 721



 Score =  101 bits (252), Expect = 1e-21
 Identities = 82/267 (30%), Positives = 122/267 (45%), Gaps = 4/267 (1%)
 Frame = +2

Query: 56   LFAWGANSYGQLGLGHKEDVLLPQQLSEFCKPGCVKRITGGGGHSAIVTDQGSLFVCGLN 235
            +++WG    G+LG G++     P+ + E  +   V  +  GG HSA VT  G L+  G  
Sbjct: 4062 VYSWGEAEDGKLGHGNRSPCDRPRVI-ESLRGIEVVDVAAGGAHSACVTAAGDLYTWGKG 4120

Query: 236  KDGQLGLGHTEDVLYFTLCKSLLGCPIQQVACGWDF--TIILTKNGQVLSCGSNSFGQLG 409
            + G+LG   +ED L   L ++L G  +  +ACG     T+ LT +  V S G   +G+LG
Sbjct: 4121 RYGRLGHSDSEDQLKPKLVEALQGHRVIDIACGSGDAQTLCLTDDDTVWSWGDGDYGKLG 4180

Query: 410  VPHGPRRCVVPQAIE-VQREKVVSIXXXXXXXXXXXXSGLVFQWGTGLASSGRRLCPGQT 586
               G   C VP  I+ +    VV +            SG V+ WG G      RL  G  
Sbjct: 4181 -RGGSDGCKVPMKIDSLTGLGVVKVECGSQFSVALTKSGAVYTWGKG---DYHRLGHGSD 4236

Query: 587  LPLFLTAKEPSKVTGLENSQAVCVLAGSGHSASLTDAGELYVWGSNKHGQLASQAA-FLP 763
              +    + P +V GL+  + + +  GS H    T+ GE+Y WG N  GQL       + 
Sbjct: 4237 DHV----RRPRQVQGLQGKKVIAIATGSLHCVCCTEDGEVYTWGDNDEGQLGDGTTNAIQ 4292

Query: 764  LPQKIEAHRFQNEKVAAVWSGWTHLVA 844
             P+ + A   Q +KV  V  G  H +A
Sbjct: 4293 RPRLVAA--LQGKKVNRVACGSAHTLA 4317



 Score = 97.4 bits (241), Expect = 2e-20
 Identities = 72/233 (30%), Positives = 108/233 (46%), Gaps = 6/233 (2%)
 Frame = +2

Query: 56   LFAWGANSYGQLGLGHKEDVLLPQQLSEFCKPGCVKRITG---GGGHSAIVTDQGSLFVC 226
            +++WG    G+LG G    +  P+ +S F      K +     G  +SA +T +G L+  
Sbjct: 517  VYSWGCGDGGRLGHGDTVPLEEPKVISAFSGKQAGKHVVHIACGSTYSAAITAEGELYTW 576

Query: 227  GLNKDGQLGLGHTEDVLYFTLCKSLLGCPIQQVACGWD--FTIILTKNGQVLSCGSNSFG 400
            G    G+LG G +ED     L   L G  +  VACG     T+ +T+NGQV S G   +G
Sbjct: 577  GRGNYGRLGHGSSEDEAIPMLVAGLKGLKVIDVACGSGDAQTLAVTENGQVWSWGDGDYG 636

Query: 401  QLGVPHGPRRCVVPQAIE-VQREKVVSIXXXXXXXXXXXXSGLVFQWGTGLASSGRRLCP 577
            +LG   G   C  P+ IE +Q   V+ +             G V+ WG G     +RL  
Sbjct: 637  KLG-RGGSDGCKTPKLIEKLQDLDVIKVRCGSQFSIALTKDGQVYSWGKG---DNQRLGH 692

Query: 578  GQTLPLFLTAKEPSKVTGLENSQAVCVLAGSGHSASLTDAGELYVWGSNKHGQ 736
            G    +    + P  + GL+  + + V AGS H  +LT+  E++ WGSN   Q
Sbjct: 693  GTEEHV----RYPKLLEGLQGKKVIDVAAGSTHCLALTEDSEVHSWGSNDQCQ 741



 Score = 95.1 bits (235), Expect = 1e-19
 Identities = 91/343 (26%), Positives = 151/343 (44%), Gaps = 12/343 (3%)
 Frame = +2

Query: 56   LFAWGANSYGQLGLGHKEDVL-LPQQLSEFCKPGCVKRIT--GGGGHSAIVTDQGSLFVC 226
            +++ G  + G+LGLG     + +P+Q++       VK++    GG H+  +T  G +F  
Sbjct: 3014 VYSCGEATNGRLGLGMSSGTVPIPRQITALSSY-VVKKVAVHSGGRHATALTVDGKVFSW 3072

Query: 227  GLNKDGQLGLGHTEDVLYFTLCKSLLGCPIQQVACGWDFTIILTKNGQVLSCGSNSFGQL 406
            G   DG+LG     +     L ++L    I+ +ACG   +  LT +G++ + G   +G+L
Sbjct: 3073 GEGDDGKLGHFSRMNCDKPRLIEALKTKRIRDIACGSSHSAALTSSGELYTWGLGEYGRL 3132

Query: 407  GVPHGPRRCVV-PQAIEV---QREKVVSIXXXXXXXXXXXXSGLVFQWGTG-LASSGRRL 571
            G  HG     + P+ ++V    R   V+              GLVF WG G     GR  
Sbjct: 3133 G--HGDNTTQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFSWGDGDFGKLGRGG 3190

Query: 572  CPGQTLPLFLTAKEPSKVTGLENSQAVCVL-AGSGHSASLTDAGELYVWGSNKHGQLASQ 748
              G  +P  +            N Q VC +  G+  S +LT +G ++ WG   + +L   
Sbjct: 3191 SEGCNIPQNIERL---------NGQGVCQIECGAQFSLALTKSGVVWTWGKGDYFRLGHG 3241

Query: 749  A-AFLPLPQKIEAHRFQNEKVAAVWSGWTHLVAQTETGKVFTWGRADYGQLGRTLESPEG 925
            +   +  PQ +E  R   +K+  V  G  H +A T++G+V+ WG  D+GQ G    +   
Sbjct: 3242 SDVHVRKPQVVEGLR--GKKIVHVAVGALHCLAVTDSGQVYAWGDNDHGQQGNGTTT--- 3296

Query: 926  WKPKKQASSLPCSRPARSVPSSLPCLTGA--TEVSCGSEHNLA 1048
                               P+ +  L G   T V+CGS H++A
Sbjct: 3297 ---------------VNRKPTLVQGLEGQKITRVACGSSHSVA 3324



 Score = 79.7 bits (195), Expect = 4e-15
 Identities = 84/331 (25%), Positives = 136/331 (41%), Gaps = 46/331 (13%)
 Frame = +2

Query: 338  DFTIILTKNGQVLSCGSNSFGQLGVPHGPRRCVVPQAIEVQREKVVSIXXXXXXXXXXXX 517
            D+T+    +G +   G N  GQLG   G +  V      +   + V +            
Sbjct: 3945 DWTLSAGGSGTIYGWGHNHRGQLGGIEGAKVKVPTPCEALATLRPVQLIGGEQTLFAVTA 4004

Query: 518  SGLVFQWGTGLASSGRRLCPGQTLPLFLTAKEPSKVTGLENSQ-----AVCVLAGSGHSA 682
             G ++  G G   +G RL  G T       +  S  T LE+ Q      V V +G  H  
Sbjct: 4005 DGKLYATGYG---AGGRLGIGGT-------ESVSTPTLLESIQHVFIKKVAVNSGGKHCL 4054

Query: 683  SLTDAGELYVWGSNKHGQLA-SQAAFLPLPQKIEAHRFQNEKVAAVWSGWTHLVAQTETG 859
            +L+  GE+Y WG  + G+L     +    P+ IE+ R    +V  V +G  H    T  G
Sbjct: 4055 ALSSEGEVYSWGEAEDGKLGHGNRSPCDRPRVIESLR--GIEVVDVAAGGAHSACVTAAG 4112

Query: 860  KVFTWGRADYGQLGRTLESPEGWKPK-------KQASSLPC-SRPARS------------ 979
             ++TWG+  YG+LG + +S +  KPK        +   + C S  A++            
Sbjct: 4113 DLYTWGKGRYGRLGHS-DSEDQLKPKLVEALQGHRVIDIACGSGDAQTLCLTDDDTVWSW 4171

Query: 980  -----------------VPSSLPCLT--GATEVSCGSEHNLAVV-GGTCYSWGWNEHGMC 1099
                             VP  +  LT  G  +V CGS+ ++A+   G  Y+WG  ++   
Sbjct: 4172 GDGDYGKLGRGGSDGCKVPMKIDSLTGLGVVKVECGSQFSVALTKSGAVYTWGKGDYHRL 4231

Query: 1100 GDGTEANVWTPKPVQALRSSSGLRLGCGAGH 1192
            G G++ +V  P+ VQ L+    + +  G+ H
Sbjct: 4232 GHGSDDHVRRPRQVQGLQGKKVIAIATGSLH 4262



 Score = 79.3 bits (194), Expect = 6e-15
 Identities = 79/337 (23%), Positives = 131/337 (38%), Gaps = 9/337 (2%)
 Frame = +2

Query: 101  HKEDVLLPQQLSEFCKPGCVKRITGGGGHSAI-VTDQGSLFVCGLNKDGQLGLGHT---- 265
            +  D+L PQ +        VK      GH  + +   G ++  G    G+LG G T    
Sbjct: 478  YNSDMLAPQLVQGLASRNIVKIAAHSDGHHYLALAATGEVYSWGCGDGGRLGHGDTVPLE 537

Query: 266  EDVLYFTLCKSLLGCPIQQVACGWDFTIILTKNGQVLSCGSNSFGQLGVPHGPRRCVVPQ 445
            E  +         G  +  +ACG  ++  +T  G++ + G  ++G+LG        +   
Sbjct: 538  EPKVISAFSGKQAGKHVVHIACGSTYSAAITAEGELYTWGRGNYGRLGHGSSEDEAIPML 597

Query: 446  AIEVQREKVVSIXXXXXXXXXXXXS--GLVFQWGTG-LASSGRRLCPGQTLPLFLTAKEP 616
               ++  KV+ +            +  G V+ WG G     GR    G         K P
Sbjct: 598  VAGLKGLKVIDVACGSGDAQTLAVTENGQVWSWGDGDYGKLGRGGSDG--------CKTP 649

Query: 617  SKVTGLENSQAVCVLAGSGHSASLTDAGELYVWGSNKHGQLA-SQAAFLPLPQKIEAHRF 793
              +  L++   + V  GS  S +LT  G++Y WG   + +L       +  P+ +E    
Sbjct: 650  KLIEKLQDLDVIKVRCGSQFSIALTKDGQVYSWGKGDNQRLGHGTEEHVRYPKLLEG--L 707

Query: 794  QNEKVAAVWSGWTHLVAQTETGKVFTWGRADYGQLGRTLESPEGWKPKKQASSLPCSRPA 973
            Q +KV  V +G TH +A TE  +V +WG  D  Q   TL                  R  
Sbjct: 708  QGKKVIDVAAGSTHCLALTEDSEVHSWGSNDQCQHFDTL------------------RVT 749

Query: 974  RSVPSSLPCLTGATEVSCGSEHNLAVVGGTCYSWGWN 1084
            +  P++LP L         S+H + +  G   S+ W+
Sbjct: 750  KPEPTALPGL--------DSKHIVGIACGPAQSFAWS 778



 Score = 72.4 bits (176), Expect = 7e-13
 Identities = 61/219 (27%), Positives = 96/219 (43%), Gaps = 3/219 (1%)
 Frame = +2

Query: 56   LFAWGANSYGQLGLGHKEDVLLPQQLSEFCKPGCVKRITGGGGHSAI-VTDQGSLFVCGL 232
            L+ WG  +YG+LG G  ED  +P  ++       +    G G    + VT+ G ++  G 
Sbjct: 573  LYTWGRGNYGRLGHGSSEDEAIPMLVAGLKGLKVIDVACGSGDAQTLAVTENGQVWSWGD 632

Query: 233  NKDGQLGLGHTEDVLYFTLCKSLLGCPIQQVACGWDFTIILTKNGQVLSCGSNSFGQLGV 412
               G+LG G ++      L + L    + +V CG  F+I LTK+GQV S G     +LG 
Sbjct: 633  GDYGKLGRGGSDGCKTPKLIEKLQDLDVIKVRCGSQFSIALTKDGQVYSWGKGDNQRLG- 691

Query: 413  PHGPRRCV-VPQAIE-VQREKVVSIXXXXXXXXXXXXSGLVFQWGTGLASSGRRLCPGQT 586
             HG    V  P+ +E +Q +KV+ +               V  WG     S  +     T
Sbjct: 692  -HGTEEHVRYPKLLEGLQGKKVIDVAAGSTHCLALTEDSEVHSWG-----SNDQCQHFDT 745

Query: 587  LPLFLTAKEPSKVTGLENSQAVCVLAGSGHSASLTDAGE 703
            L   +T  EP+ + GL++   V +  G   S + +   E
Sbjct: 746  LR--VTKPEPTALPGLDSKHIVGIACGPAQSFAWSSCSE 782



 Score = 70.9 bits (172), Expect = 2e-12
 Identities = 59/204 (28%), Positives = 89/204 (43%), Gaps = 10/204 (4%)
 Frame = +2

Query: 614  PSKVTGLENSQAVCVLAGSG--HSASLTDAGELYVWGSNKHGQLA-SQAAFLPLPQKIEA 784
            P  V GL +   V + A S   H  +L   GE+Y WG    G+L       L  P+ I A
Sbjct: 485  PQLVQGLASRNIVKIAAHSDGHHYLALAATGEVYSWGCGDGGRLGHGDTVPLEEPKVISA 544

Query: 785  H--RFQNEKVAAVWSGWTHLVAQTETGKVFTWGRADYGQLGRTLESPEGWKPKKQASSLP 958
               +   + V  +  G T+  A T  G+++TWGR +YG+LG      E            
Sbjct: 545  FSGKQAGKHVVHIACGSTYSAAITAEGELYTWGRGNYGRLGHGSSEDE------------ 592

Query: 959  CSRPARSVPSSLPCLTG--ATEVSCGS--EHNLAVV-GGTCYSWGWNEHGMCGDGTEANV 1123
                  ++P  +  L G    +V+CGS     LAV   G  +SWG  ++G  G G     
Sbjct: 593  ------AIPMLVAGLKGLKVIDVACGSGDAQTLAVTENGQVWSWGDGDYGKLGRGGSDGC 646

Query: 1124 WTPKPVQALRSSSGLRLGCGAGHS 1195
             TPK ++ L+    +++ CG+  S
Sbjct: 647  KTPKLIEKLQDLDVIKVRCGSQFS 670



 Score = 51.6 bits (122), Expect = 1e-06
 Identities = 32/99 (32%), Positives = 49/99 (49%)
 Frame = +2

Query: 53   ALFAWGANSYGQLGLGHKEDVLLPQQLSEFCKPGCVKRITGGGGHSAIVTDQGSLFVCGL 232
            A++ WG   Y +LG G  + V  P+Q+ +  +   V  I  G  H    T+ G ++  G 
Sbjct: 4219 AVYTWGKGDYHRLGHGSDDHVRRPRQV-QGLQGKKVIAIATGSLHCVCCTEDGEVYTWGD 4277

Query: 233  NKDGQLGLGHTEDVLYFTLCKSLLGCPIQQVACGWDFTI 349
            N +GQLG G T  +    L  +L G  + +VACG   T+
Sbjct: 4278 NDEGQLGDGTTNAIQRPRLVAALQGKKVNRVACGSAHTL 4316


>ref|NP_001171424.1| X-linked retinitis pigmentosa GTPase regulator isoform 5 [Mus
           musculus].
          Length = 557

 Score =  113 bits (282), Expect = 4e-25
 Identities = 80/293 (27%), Positives = 143/293 (48%), Gaps = 6/293 (2%)
 Frame = +2

Query: 56  LFAWGANSYGQLGLGHKEDVLLPQQLSEFCKPGCVKRITGGGGHSAIVTDQGSLFVCGLN 235
           L+ +G+N++GQLGLG K  ++ P  +    KP  VK    G  H+ + TD G ++  G N
Sbjct: 94  LYMFGSNNWGQLGLGSKAAIIKPTCIKAL-KPEKVKLAACGRNHTLVSTDTGGVYAAGGN 152

Query: 236 KDGQLGLGHTED------VLYFTLCKSLLGCPIQQVACGWDFTIILTKNGQVLSCGSNSF 397
            +GQLGLG T+D      +++FT   +     I+Q++ G + +  LT++G++   G NS 
Sbjct: 153 NEGQLGLGDTDDRDTFHQIVFFTPADT-----IKQLSAGANTSAALTEDGKLFMWGDNSE 207

Query: 398 GQLGVPHGPRRCVVPQAIEVQREKVVSIXXXXXXXXXXXXSGLVFQWGTGLASSGRRLCP 577
           GQ+G+      C +P  + V +  +  I             G ++ +G     +G+   P
Sbjct: 208 GQIGLEDKSNVC-IPHEVTVGK-PISWISCGYYHSAFVTMDGELYTFGE--PENGKLGLP 263

Query: 578 GQTLPLFLTAKEPSKVTGLENSQAVCVLAGSGHSASLTDAGELYVWGSNKHGQLASQAAF 757
            +   L +  + P +V G+   + + V  G GH+  LT+   +Y +G  + GQL      
Sbjct: 264 NE---LLMNHRSPQRVLGIP-ERVIQVACGGGHTVVLTEK-VVYAFGLGQFGQLGLGTFL 318

Query: 758 LPLPQKIEAHRFQNEKVAAVWSGWTHLVAQTETGKVFTWGRADYGQLGRTLES 916
               +     R +++K+  +  G  H    TE G ++T+G   +G+LG  +E+
Sbjct: 319 FETSEPKIIERIKDQKICHISCGENHTALMTELGLLYTFGDGRHGKLGLGMEN 371



 Score = 85.9 bits (211), Expect = 6e-17
 Identities = 93/356 (26%), Positives = 134/356 (37%), Gaps = 17/356 (4%)
 Frame = +2

Query: 176  GGGHSAIVTDQGSLFVCGLNKDGQLGLGHTEDVLYFTLCKSLLGCPIQQVACGWDFTIIL 355
            G  H+AIVT    L++ G N  GQLGLG    ++  T  K+L    ++  ACG + T++ 
Sbjct: 81   GDEHTAIVTGNNKLYMFGSNNWGQLGLGSKAAIIKPTCIKALKPEKVKLAACGRNHTLVS 140

Query: 356  TKNGQVLSCGSNSFGQLGVPHGPRRCVVPQAI-EVQREKVVSIXXXXXXXXXXXXSGLVF 532
            T  G V + G N+ GQLG+     R    Q +     + +  +             G +F
Sbjct: 141  TDTGGVYAAGGNNEGQLGLGDTDDRDTFHQIVFFTPADTIKQLSAGANTSAALTEDGKLF 200

Query: 533  QWGTGLASSGRRLCPGQTLPLFLTAKEPSKVTGLENSQAVC-------------VLAGSG 673
             WG    S G+                     GLE+   VC             +  G  
Sbjct: 201  MWGDN--SEGQ--------------------IGLEDKSNVCIPHEVTVGKPISWISCGYY 238

Query: 674  HSASLTDAGELYVWGSNKHGQLASQAAFLPLPQKIEAHRFQNEKVAAVWSGWTHLVAQTE 853
            HSA +T  GELY +G  ++G+L      L   +  +      E+V  V  G  H V  TE
Sbjct: 239  HSAFVTMDGELYTFGEPENGKLGLPNELLMNHRSPQRVLGIPERVIQVACGGGHTVVLTE 298

Query: 854  TGKVFTWGRADYGQLGRTLESPEGWKPKKQASSLPCSRPARSVPSSLPCLTGATEVSCGS 1033
               V+ +G   +GQLG      E  +PK              +     C      +SCG 
Sbjct: 299  K-VVYAFGLGQFGQLGLGTFLFETSEPK----------IIERIKDQKIC-----HISCGE 342

Query: 1034 EHN-LAVVGGTCYSWGWNEHGMCGDGTE--ANVWTPKPVQALRSSSGLRLGCGAGH 1192
             H  L    G  Y++G   HG  G G E   N + P         +   + CG  H
Sbjct: 343  NHTALMTELGLLYTFGDGRHGKLGLGMENFTNQFFPTLCSNFLRFAVQLIACGGCH 398



 Score = 58.9 bits (141), Expect = 8e-09
 Identities = 57/197 (28%), Positives = 89/197 (45%), Gaps = 3/197 (1%)
 Frame = +2

Query: 614  PSKVTGLENSQAVCVLAGSGHSASLTDAGELYVWGSNKHGQ--LASQAAFLPLPQKIEAH 787
            PSK    +N   +C+  G  H+A +T   +LY++GSN  GQ  L S+AA +  P  I+A 
Sbjct: 65   PSKFW-FKNDIPICLSCGDEHTAIVTGNNKLYMFGSNNWGQLGLGSKAAIIK-PTCIKAL 122

Query: 788  RFQNEKVAAVWSGWTHLVAQTETGKVFTWGRADYGQLGRTLESPEGWKPKKQASSLPCSR 967
            + +  K+AA   G  H +  T+TG V+  G  + GQLG           +     +    
Sbjct: 123  KPEKVKLAA--CGRNHTLVSTDTGGVYAAGGNNEGQLGL-----GDTDDRDTFHQIVFFT 175

Query: 968  PARSVPSSLPCLTGATEVSCGSEHNLAVV-GGTCYSWGWNEHGMCGDGTEANVWTPKPVQ 1144
            PA ++           ++S G+  + A+   G  + WG N  G  G   ++NV  P  V 
Sbjct: 176  PADTI----------KQLSAGANTSAALTEDGKLFMWGDNSEGQIGLEDKSNVCIPHEVT 225

Query: 1145 ALRSSSGLRLGCGAGHS 1195
              +  S   + CG  HS
Sbjct: 226  VGKPISW--ISCGYYHS 240


>ref|NP_001171422.1| X-linked retinitis pigmentosa GTPase regulator isoform 2 [Mus
           musculus].
          Length = 972

 Score =  113 bits (282), Expect = 4e-25
 Identities = 80/293 (27%), Positives = 143/293 (48%), Gaps = 6/293 (2%)
 Frame = +2

Query: 56  LFAWGANSYGQLGLGHKEDVLLPQQLSEFCKPGCVKRITGGGGHSAIVTDQGSLFVCGLN 235
           L+ +G+N++GQLGLG K  ++ P  +    KP  VK    G  H+ + TD G ++  G N
Sbjct: 94  LYMFGSNNWGQLGLGSKAAIIKPTCIKAL-KPEKVKLAACGRNHTLVSTDTGGVYAAGGN 152

Query: 236 KDGQLGLGHTED------VLYFTLCKSLLGCPIQQVACGWDFTIILTKNGQVLSCGSNSF 397
            +GQLGLG T+D      +++FT   +     I+Q++ G + +  LT++G++   G NS 
Sbjct: 153 NEGQLGLGDTDDRDTFHQIVFFTPADT-----IKQLSAGANTSAALTEDGKLFMWGDNSE 207

Query: 398 GQLGVPHGPRRCVVPQAIEVQREKVVSIXXXXXXXXXXXXSGLVFQWGTGLASSGRRLCP 577
           GQ+G+      C +P  + V +  +  I             G ++ +G     +G+   P
Sbjct: 208 GQIGLEDKSNVC-IPHEVTVGK-PISWISCGYYHSAFVTMDGELYTFGE--PENGKLGLP 263

Query: 578 GQTLPLFLTAKEPSKVTGLENSQAVCVLAGSGHSASLTDAGELYVWGSNKHGQLASQAAF 757
            +   L +  + P +V G+   + + V  G GH+  LT+   +Y +G  + GQL      
Sbjct: 264 NE---LLMNHRSPQRVLGIP-ERVIQVACGGGHTVVLTEK-VVYAFGLGQFGQLGLGTFL 318

Query: 758 LPLPQKIEAHRFQNEKVAAVWSGWTHLVAQTETGKVFTWGRADYGQLGRTLES 916
               +     R +++K+  +  G  H    TE G ++T+G   +G+LG  +E+
Sbjct: 319 FETSEPKIIERIKDQKICHISCGENHTALMTELGLLYTFGDGRHGKLGLGMEN 371



 Score = 85.9 bits (211), Expect = 6e-17
 Identities = 93/356 (26%), Positives = 134/356 (37%), Gaps = 17/356 (4%)
 Frame = +2

Query: 176  GGGHSAIVTDQGSLFVCGLNKDGQLGLGHTEDVLYFTLCKSLLGCPIQQVACGWDFTIIL 355
            G  H+AIVT    L++ G N  GQLGLG    ++  T  K+L    ++  ACG + T++ 
Sbjct: 81   GDEHTAIVTGNNKLYMFGSNNWGQLGLGSKAAIIKPTCIKALKPEKVKLAACGRNHTLVS 140

Query: 356  TKNGQVLSCGSNSFGQLGVPHGPRRCVVPQAI-EVQREKVVSIXXXXXXXXXXXXSGLVF 532
            T  G V + G N+ GQLG+     R    Q +     + +  +             G +F
Sbjct: 141  TDTGGVYAAGGNNEGQLGLGDTDDRDTFHQIVFFTPADTIKQLSAGANTSAALTEDGKLF 200

Query: 533  QWGTGLASSGRRLCPGQTLPLFLTAKEPSKVTGLENSQAVC-------------VLAGSG 673
             WG    S G+                     GLE+   VC             +  G  
Sbjct: 201  MWGDN--SEGQ--------------------IGLEDKSNVCIPHEVTVGKPISWISCGYY 238

Query: 674  HSASLTDAGELYVWGSNKHGQLASQAAFLPLPQKIEAHRFQNEKVAAVWSGWTHLVAQTE 853
            HSA +T  GELY +G  ++G+L      L   +  +      E+V  V  G  H V  TE
Sbjct: 239  HSAFVTMDGELYTFGEPENGKLGLPNELLMNHRSPQRVLGIPERVIQVACGGGHTVVLTE 298

Query: 854  TGKVFTWGRADYGQLGRTLESPEGWKPKKQASSLPCSRPARSVPSSLPCLTGATEVSCGS 1033
               V+ +G   +GQLG      E  +PK              +     C      +SCG 
Sbjct: 299  K-VVYAFGLGQFGQLGLGTFLFETSEPK----------IIERIKDQKIC-----HISCGE 342

Query: 1034 EHN-LAVVGGTCYSWGWNEHGMCGDGTE--ANVWTPKPVQALRSSSGLRLGCGAGH 1192
             H  L    G  Y++G   HG  G G E   N + P         +   + CG  H
Sbjct: 343  NHTALMTELGLLYTFGDGRHGKLGLGMENFTNQFFPTLCSNFLRFAVQLIACGGCH 398



 Score = 58.9 bits (141), Expect = 8e-09
 Identities = 57/197 (28%), Positives = 89/197 (45%), Gaps = 3/197 (1%)
 Frame = +2

Query: 614  PSKVTGLENSQAVCVLAGSGHSASLTDAGELYVWGSNKHGQ--LASQAAFLPLPQKIEAH 787
            PSK    +N   +C+  G  H+A +T   +LY++GSN  GQ  L S+AA +  P  I+A 
Sbjct: 65   PSKFW-FKNDIPICLSCGDEHTAIVTGNNKLYMFGSNNWGQLGLGSKAAIIK-PTCIKAL 122

Query: 788  RFQNEKVAAVWSGWTHLVAQTETGKVFTWGRADYGQLGRTLESPEGWKPKKQASSLPCSR 967
            + +  K+AA   G  H +  T+TG V+  G  + GQLG           +     +    
Sbjct: 123  KPEKVKLAA--CGRNHTLVSTDTGGVYAAGGNNEGQLGL-----GDTDDRDTFHQIVFFT 175

Query: 968  PARSVPSSLPCLTGATEVSCGSEHNLAVV-GGTCYSWGWNEHGMCGDGTEANVWTPKPVQ 1144
            PA ++           ++S G+  + A+   G  + WG N  G  G   ++NV  P  V 
Sbjct: 176  PADTI----------KQLSAGANTSAALTEDGKLFMWGDNSEGQIGLEDKSNVCIPHEVT 225

Query: 1145 ALRSSSGLRLGCGAGHS 1195
              +  S   + CG  HS
Sbjct: 226  VGKPISW--ISCGYYHS 240


>ref|NP_001171421.1| X-linked retinitis pigmentosa GTPase regulator isoform 1 [Mus
           musculus].
          Length = 1039

 Score =  113 bits (282), Expect = 4e-25
 Identities = 80/293 (27%), Positives = 143/293 (48%), Gaps = 6/293 (2%)
 Frame = +2

Query: 56  LFAWGANSYGQLGLGHKEDVLLPQQLSEFCKPGCVKRITGGGGHSAIVTDQGSLFVCGLN 235
           L+ +G+N++GQLGLG K  ++ P  +    KP  VK    G  H+ + TD G ++  G N
Sbjct: 94  LYMFGSNNWGQLGLGSKAAIIKPTCIKAL-KPEKVKLAACGRNHTLVSTDTGGVYAAGGN 152

Query: 236 KDGQLGLGHTED------VLYFTLCKSLLGCPIQQVACGWDFTIILTKNGQVLSCGSNSF 397
            +GQLGLG T+D      +++FT   +     I+Q++ G + +  LT++G++   G NS 
Sbjct: 153 NEGQLGLGDTDDRDTFHQIVFFTPADT-----IKQLSAGANTSAALTEDGKLFMWGDNSE 207

Query: 398 GQLGVPHGPRRCVVPQAIEVQREKVVSIXXXXXXXXXXXXSGLVFQWGTGLASSGRRLCP 577
           GQ+G+      C +P  + V +  +  I             G ++ +G     +G+   P
Sbjct: 208 GQIGLEDKSNVC-IPHEVTVGK-PISWISCGYYHSAFVTMDGELYTFGE--PENGKLGLP 263

Query: 578 GQTLPLFLTAKEPSKVTGLENSQAVCVLAGSGHSASLTDAGELYVWGSNKHGQLASQAAF 757
            +   L +  + P +V G+   + + V  G GH+  LT+   +Y +G  + GQL      
Sbjct: 264 NE---LLMNHRSPQRVLGIP-ERVIQVACGGGHTVVLTEK-VVYAFGLGQFGQLGLGTFL 318

Query: 758 LPLPQKIEAHRFQNEKVAAVWSGWTHLVAQTETGKVFTWGRADYGQLGRTLES 916
               +     R +++K+  +  G  H    TE G ++T+G   +G+LG  +E+
Sbjct: 319 FETSEPKIIERIKDQKICHISCGENHTALMTELGLLYTFGDGRHGKLGLGMEN 371



 Score = 85.9 bits (211), Expect = 6e-17
 Identities = 93/356 (26%), Positives = 134/356 (37%), Gaps = 17/356 (4%)
 Frame = +2

Query: 176  GGGHSAIVTDQGSLFVCGLNKDGQLGLGHTEDVLYFTLCKSLLGCPIQQVACGWDFTIIL 355
            G  H+AIVT    L++ G N  GQLGLG    ++  T  K+L    ++  ACG + T++ 
Sbjct: 81   GDEHTAIVTGNNKLYMFGSNNWGQLGLGSKAAIIKPTCIKALKPEKVKLAACGRNHTLVS 140

Query: 356  TKNGQVLSCGSNSFGQLGVPHGPRRCVVPQAI-EVQREKVVSIXXXXXXXXXXXXSGLVF 532
            T  G V + G N+ GQLG+     R    Q +     + +  +             G +F
Sbjct: 141  TDTGGVYAAGGNNEGQLGLGDTDDRDTFHQIVFFTPADTIKQLSAGANTSAALTEDGKLF 200

Query: 533  QWGTGLASSGRRLCPGQTLPLFLTAKEPSKVTGLENSQAVC-------------VLAGSG 673
             WG    S G+                     GLE+   VC             +  G  
Sbjct: 201  MWGDN--SEGQ--------------------IGLEDKSNVCIPHEVTVGKPISWISCGYY 238

Query: 674  HSASLTDAGELYVWGSNKHGQLASQAAFLPLPQKIEAHRFQNEKVAAVWSGWTHLVAQTE 853
            HSA +T  GELY +G  ++G+L      L   +  +      E+V  V  G  H V  TE
Sbjct: 239  HSAFVTMDGELYTFGEPENGKLGLPNELLMNHRSPQRVLGIPERVIQVACGGGHTVVLTE 298

Query: 854  TGKVFTWGRADYGQLGRTLESPEGWKPKKQASSLPCSRPARSVPSSLPCLTGATEVSCGS 1033
               V+ +G   +GQLG      E  +PK              +     C      +SCG 
Sbjct: 299  K-VVYAFGLGQFGQLGLGTFLFETSEPK----------IIERIKDQKIC-----HISCGE 342

Query: 1034 EHN-LAVVGGTCYSWGWNEHGMCGDGTE--ANVWTPKPVQALRSSSGLRLGCGAGH 1192
             H  L    G  Y++G   HG  G G E   N + P         +   + CG  H
Sbjct: 343  NHTALMTELGLLYTFGDGRHGKLGLGMENFTNQFFPTLCSNFLRFAVQLIACGGCH 398



 Score = 58.9 bits (141), Expect = 8e-09
 Identities = 57/197 (28%), Positives = 89/197 (45%), Gaps = 3/197 (1%)
 Frame = +2

Query: 614  PSKVTGLENSQAVCVLAGSGHSASLTDAGELYVWGSNKHGQ--LASQAAFLPLPQKIEAH 787
            PSK    +N   +C+  G  H+A +T   +LY++GSN  GQ  L S+AA +  P  I+A 
Sbjct: 65   PSKFW-FKNDIPICLSCGDEHTAIVTGNNKLYMFGSNNWGQLGLGSKAAIIK-PTCIKAL 122

Query: 788  RFQNEKVAAVWSGWTHLVAQTETGKVFTWGRADYGQLGRTLESPEGWKPKKQASSLPCSR 967
            + +  K+AA   G  H +  T+TG V+  G  + GQLG           +     +    
Sbjct: 123  KPEKVKLAA--CGRNHTLVSTDTGGVYAAGGNNEGQLGL-----GDTDDRDTFHQIVFFT 175

Query: 968  PARSVPSSLPCLTGATEVSCGSEHNLAVV-GGTCYSWGWNEHGMCGDGTEANVWTPKPVQ 1144
            PA ++           ++S G+  + A+   G  + WG N  G  G   ++NV  P  V 
Sbjct: 176  PADTI----------KQLSAGANTSAALTEDGKLFMWGDNSEGQIGLEDKSNVCIPHEVT 225

Query: 1145 ALRSSSGLRLGCGAGHS 1195
              +  S   + CG  HS
Sbjct: 226  VGKPISW--ISCGYYHS 240


>ref|NP_035415.1| X-linked retinitis pigmentosa GTPase regulator isoform 3 [Mus
           musculus].
          Length = 746

 Score =  113 bits (282), Expect = 4e-25
 Identities = 80/293 (27%), Positives = 143/293 (48%), Gaps = 6/293 (2%)
 Frame = +2

Query: 56  LFAWGANSYGQLGLGHKEDVLLPQQLSEFCKPGCVKRITGGGGHSAIVTDQGSLFVCGLN 235
           L+ +G+N++GQLGLG K  ++ P  +    KP  VK    G  H+ + TD G ++  G N
Sbjct: 94  LYMFGSNNWGQLGLGSKAAIIKPTCIKAL-KPEKVKLAACGRNHTLVSTDTGGVYAAGGN 152

Query: 236 KDGQLGLGHTED------VLYFTLCKSLLGCPIQQVACGWDFTIILTKNGQVLSCGSNSF 397
            +GQLGLG T+D      +++FT   +     I+Q++ G + +  LT++G++   G NS 
Sbjct: 153 NEGQLGLGDTDDRDTFHQIVFFTPADT-----IKQLSAGANTSAALTEDGKLFMWGDNSE 207

Query: 398 GQLGVPHGPRRCVVPQAIEVQREKVVSIXXXXXXXXXXXXSGLVFQWGTGLASSGRRLCP 577
           GQ+G+      C +P  + V +  +  I             G ++ +G     +G+   P
Sbjct: 208 GQIGLEDKSNVC-IPHEVTVGK-PISWISCGYYHSAFVTMDGELYTFGE--PENGKLGLP 263

Query: 578 GQTLPLFLTAKEPSKVTGLENSQAVCVLAGSGHSASLTDAGELYVWGSNKHGQLASQAAF 757
            +   L +  + P +V G+   + + V  G GH+  LT+   +Y +G  + GQL      
Sbjct: 264 NE---LLMNHRSPQRVLGIP-ERVIQVACGGGHTVVLTEK-VVYAFGLGQFGQLGLGTFL 318

Query: 758 LPLPQKIEAHRFQNEKVAAVWSGWTHLVAQTETGKVFTWGRADYGQLGRTLES 916
               +     R +++K+  +  G  H    TE G ++T+G   +G+LG  +E+
Sbjct: 319 FETSEPKIIERIKDQKICHISCGENHTALMTELGLLYTFGDGRHGKLGLGMEN 371



 Score = 85.9 bits (211), Expect = 6e-17
 Identities = 93/356 (26%), Positives = 134/356 (37%), Gaps = 17/356 (4%)
 Frame = +2

Query: 176  GGGHSAIVTDQGSLFVCGLNKDGQLGLGHTEDVLYFTLCKSLLGCPIQQVACGWDFTIIL 355
            G  H+AIVT    L++ G N  GQLGLG    ++  T  K+L    ++  ACG + T++ 
Sbjct: 81   GDEHTAIVTGNNKLYMFGSNNWGQLGLGSKAAIIKPTCIKALKPEKVKLAACGRNHTLVS 140

Query: 356  TKNGQVLSCGSNSFGQLGVPHGPRRCVVPQAI-EVQREKVVSIXXXXXXXXXXXXSGLVF 532
            T  G V + G N+ GQLG+     R    Q +     + +  +             G +F
Sbjct: 141  TDTGGVYAAGGNNEGQLGLGDTDDRDTFHQIVFFTPADTIKQLSAGANTSAALTEDGKLF 200

Query: 533  QWGTGLASSGRRLCPGQTLPLFLTAKEPSKVTGLENSQAVC-------------VLAGSG 673
             WG    S G+                     GLE+   VC             +  G  
Sbjct: 201  MWGDN--SEGQ--------------------IGLEDKSNVCIPHEVTVGKPISWISCGYY 238

Query: 674  HSASLTDAGELYVWGSNKHGQLASQAAFLPLPQKIEAHRFQNEKVAAVWSGWTHLVAQTE 853
            HSA +T  GELY +G  ++G+L      L   +  +      E+V  V  G  H V  TE
Sbjct: 239  HSAFVTMDGELYTFGEPENGKLGLPNELLMNHRSPQRVLGIPERVIQVACGGGHTVVLTE 298

Query: 854  TGKVFTWGRADYGQLGRTLESPEGWKPKKQASSLPCSRPARSVPSSLPCLTGATEVSCGS 1033
               V+ +G   +GQLG      E  +PK              +     C      +SCG 
Sbjct: 299  K-VVYAFGLGQFGQLGLGTFLFETSEPK----------IIERIKDQKIC-----HISCGE 342

Query: 1034 EHN-LAVVGGTCYSWGWNEHGMCGDGTE--ANVWTPKPVQALRSSSGLRLGCGAGH 1192
             H  L    G  Y++G   HG  G G E   N + P         +   + CG  H
Sbjct: 343  NHTALMTELGLLYTFGDGRHGKLGLGMENFTNQFFPTLCSNFLRFAVQLIACGGCH 398



 Score = 58.9 bits (141), Expect = 8e-09
 Identities = 57/197 (28%), Positives = 89/197 (45%), Gaps = 3/197 (1%)
 Frame = +2

Query: 614  PSKVTGLENSQAVCVLAGSGHSASLTDAGELYVWGSNKHGQ--LASQAAFLPLPQKIEAH 787
            PSK    +N   +C+  G  H+A +T   +LY++GSN  GQ  L S+AA +  P  I+A 
Sbjct: 65   PSKFW-FKNDIPICLSCGDEHTAIVTGNNKLYMFGSNNWGQLGLGSKAAIIK-PTCIKAL 122

Query: 788  RFQNEKVAAVWSGWTHLVAQTETGKVFTWGRADYGQLGRTLESPEGWKPKKQASSLPCSR 967
            + +  K+AA   G  H +  T+TG V+  G  + GQLG           +     +    
Sbjct: 123  KPEKVKLAA--CGRNHTLVSTDTGGVYAAGGNNEGQLGL-----GDTDDRDTFHQIVFFT 175

Query: 968  PARSVPSSLPCLTGATEVSCGSEHNLAVV-GGTCYSWGWNEHGMCGDGTEANVWTPKPVQ 1144
            PA ++           ++S G+  + A+   G  + WG N  G  G   ++NV  P  V 
Sbjct: 176  PADTI----------KQLSAGANTSAALTEDGKLFMWGDNSEGQIGLEDKSNVCIPHEVT 225

Query: 1145 ALRSSSGLRLGCGAGHS 1195
              +  S   + CG  HS
Sbjct: 226  VGKPISW--ISCGYYHS 240


>ref|NP_001171423.1| X-linked retinitis pigmentosa GTPase regulator isoform 4 [Mus
           musculus].
          Length = 651

 Score =  110 bits (276), Expect = 2e-24
 Identities = 79/290 (27%), Positives = 141/290 (48%), Gaps = 6/290 (2%)
 Frame = +2

Query: 65  WGANSYGQLGLGHKEDVLLPQQLSEFCKPGCVKRITGGGGHSAIVTDQGSLFVCGLNKDG 244
           +G+N++GQLGLG K  ++ P  +    KP  VK    G  H+ + TD G ++  G N +G
Sbjct: 2   FGSNNWGQLGLGSKAAIIKPTCIKAL-KPEKVKLAACGRNHTLVSTDTGGVYAAGGNNEG 60

Query: 245 QLGLGHTED------VLYFTLCKSLLGCPIQQVACGWDFTIILTKNGQVLSCGSNSFGQL 406
           QLGLG T+D      +++FT   +     I+Q++ G + +  LT++G++   G NS GQ+
Sbjct: 61  QLGLGDTDDRDTFHQIVFFTPADT-----IKQLSAGANTSAALTEDGKLFMWGDNSEGQI 115

Query: 407 GVPHGPRRCVVPQAIEVQREKVVSIXXXXXXXXXXXXSGLVFQWGTGLASSGRRLCPGQT 586
           G+      C +P  + V +  +  I             G ++ +G     +G+   P + 
Sbjct: 116 GLEDKSNVC-IPHEVTVGK-PISWISCGYYHSAFVTMDGELYTFGE--PENGKLGLPNE- 170

Query: 587 LPLFLTAKEPSKVTGLENSQAVCVLAGSGHSASLTDAGELYVWGSNKHGQLASQAAFLPL 766
             L +  + P +V G+   + + V  G GH+  LT+   +Y +G  + GQL         
Sbjct: 171 --LLMNHRSPQRVLGIP-ERVIQVACGGGHTVVLTEK-VVYAFGLGQFGQLGLGTFLFET 226

Query: 767 PQKIEAHRFQNEKVAAVWSGWTHLVAQTETGKVFTWGRADYGQLGRTLES 916
            +     R +++K+  +  G  H    TE G ++T+G   +G+LG  +E+
Sbjct: 227 SEPKIIERIKDQKICHISCGENHTALMTELGLLYTFGDGRHGKLGLGMEN 276



 Score = 86.3 bits (212), Expect = 5e-17
 Identities = 63/229 (27%), Positives = 112/229 (48%), Gaps = 1/229 (0%)
 Frame = +2

Query: 56  LFAWGANSYGQLGLGHKEDVLLPQQLSEFCKPGCVKRITGGGGHSAIVTDQGSLFVCGLN 235
           ++A G N+ GQLGLG  +D     Q+  F     +K+++ G   SA +T+ G LF+ G N
Sbjct: 51  VYAAGGNNEGQLGLGDTDDRDTFHQIVFFTPADTIKQLSAGANTSAALTEDGKLFMWGDN 110

Query: 236 KDGQLGLGHTEDVLYFTLCKSLLGCPIQQVACGWDFTIILTKNGQVLSCGSNSFGQLGVP 415
            +GQ+GL    +V      +  +G PI  ++CG+  +  +T +G++ + G    G+LG+P
Sbjct: 111 SEGQIGLEDKSNVC--IPHEVTVGKPISWISCGYYHSAFVTMDGELYTFGEPENGKLGLP 168

Query: 416 HG-PRRCVVPQAIEVQREKVVSIXXXXXXXXXXXXSGLVFQWGTGLASSGRRLCPGQTLP 592
           +        PQ +    E+V+ +              +V+ +G G          G    
Sbjct: 169 NELLMNHRSPQRVLGIPERVIQVACGGGHTVVLTEK-VVYAFGLGQFGQ-----LGLGTF 222

Query: 593 LFLTAKEPSKVTGLENSQAVCVLAGSGHSASLTDAGELYVWGSNKHGQL 739
           LF T+ EP  +  +++ +   +  G  H+A +T+ G LY +G  +HG+L
Sbjct: 223 LFETS-EPKIIERIKDQKICHISCGENHTALMTELGLLYTFGDGRHGKL 270



 Score = 72.8 bits (177), Expect = 5e-13
 Identities = 86/339 (25%), Positives = 124/339 (36%), Gaps = 17/339 (5%)
 Frame = +2

Query: 227  GLNKDGQLGLGHTEDVLYFTLCKSLLGCPIQQVACGWDFTIILTKNGQVLSCGSNSFGQL 406
            G N  GQLGLG    ++  T  K+L    ++  ACG + T++ T  G V + G N+ GQL
Sbjct: 3    GSNNWGQLGLGSKAAIIKPTCIKALKPEKVKLAACGRNHTLVSTDTGGVYAAGGNNEGQL 62

Query: 407  GVPHGPRRCVVPQAI-EVQREKVVSIXXXXXXXXXXXXSGLVFQWGTGLASSGRRLCPGQ 583
            G+     R    Q +     + +  +             G +F WG    S G+      
Sbjct: 63   GLGDTDDRDTFHQIVFFTPADTIKQLSAGANTSAALTEDGKLFMWGDN--SEGQ------ 114

Query: 584  TLPLFLTAKEPSKVTGLENSQAVC-------------VLAGSGHSASLTDAGELYVWGSN 724
                           GLE+   VC             +  G  HSA +T  GELY +G  
Sbjct: 115  --------------IGLEDKSNVCIPHEVTVGKPISWISCGYYHSAFVTMDGELYTFGEP 160

Query: 725  KHGQLASQAAFLPLPQKIEAHRFQNEKVAAVWSGWTHLVAQTETGKVFTWGRADYGQLGR 904
            ++G+L      L   +  +      E+V  V  G  H V  TE   V+ +G   +GQLG 
Sbjct: 161  ENGKLGLPNELLMNHRSPQRVLGIPERVIQVACGGGHTVVLTEK-VVYAFGLGQFGQLGL 219

Query: 905  TLESPEGWKPKKQASSLPCSRPARSVPSSLPCLTGATEVSCGSEHN-LAVVGGTCYSWGW 1081
                 E  +PK              +     C      +SCG  H  L    G  Y++G 
Sbjct: 220  GTFLFETSEPK----------IIERIKDQKIC-----HISCGENHTALMTELGLLYTFGD 264

Query: 1082 NEHGMCGDGTE--ANVWTPKPVQALRSSSGLRLGCGAGH 1192
              HG  G G E   N + P         +   + CG  H
Sbjct: 265  GRHGKLGLGMENFTNQFFPTLCSNFLRFAVQLIACGGCH 303


  Database: RefSeq49_MP.fasta
    Posted date:  Oct 17, 2011  1:42 PM
  Number of letters in database: 15,617,559
  Number of sequences in database:  30,036
  
Lambda     K      H
   0.318    0.134    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 30036
Number of Hits to DB: 49,214,187
Number of extensions: 1536052
Number of successful extensions: 6555
Number of sequences better than 1.0e-05: 25
Number of HSP's gapped: 6110
Number of HSP's successfully gapped: 106
Length of query: 421
Length of database: 15,617,559
Length adjustment: 104
Effective length of query: 317
Effective length of database: 12,493,815
Effective search space: 3960539355
Effective search space used: 3960539355
Neighboring words threshold: 12
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 35 (18.1 bits)

BLASTX 2.2.24 [Aug-08-2010]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= 20110601C-004015
         (1263 letters)

Database: RefSeq49_SP.fasta 
           24,897 sequences; 11,343,932 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

Alignment   gi|XP_003122992.2| PREDICTED: secretion-regulating guanine nucl...   645   0.0  
Alignment   gi|XP_003129377.2| PREDICTED: probable E3 ubiquitin-protein lig...   134   1e-31
Alignment   gi|XP_003133446.2| PREDICTED: e3 ubiquitin-protein ligase HERC2...   122   4e-28
Alignment   gi|XP_003357882.1| PREDICTED: RCC1 and BTB domain-containing pr...   106   3e-23
Alignment   gi|XP_003135065.2| PREDICTED: hypothetical protein LOC100511730...   105   7e-23
Alignment   gi|XP_001928937.1| PREDICTED: RCC1 and BTB domain-containing pr...   103   2e-22
Alignment   gi|XP_003129374.2| PREDICTED: probable E3 ubiquitin-protein lig...   100   2e-21
Alignment   gi|XP_001927286.3| PREDICTED: probable E3 ubiquitin-protein lig...    97   1e-20
Alignment   gi|XP_003361480.1| PREDICTED: probable E3 ubiquitin-protein lig...    94   2e-19
Alignment   gi|XP_003359267.1| PREDICTED: probable E3 ubiquitin-protein lig...    87   2e-17

>ref|XP_003122992.2| PREDICTED: secretion-regulating guanine nucleotide exchange
            factor-like [Sus scrofa].
          Length = 378

 Score =  645 bits (1663), Expect = 0.0
 Identities = 313/328 (95%), Positives = 314/328 (95%)
 Frame = +2

Query: 50   TALFAWGANSYGQLGLGHKEDVLLPQQLSEFCKPGCVKRITGGGGHSAIVTDQGSLFVCG 229
            TALFAWGANSYGQLGLGHKEDVLLPQQLSEFCKPGCVKRITGGGGHSAIVTDQGSLFVCG
Sbjct: 15   TALFAWGANSYGQLGLGHKEDVLLPQQLSEFCKPGCVKRITGGGGHSAIVTDQGSLFVCG 74

Query: 230  LNKDGQLGLGHTEDVLYFTLCKSLLGCPIQQVACGWDFTIILTKNGQVLSCGSNSFGQLG 409
            LNKDGQLGLGHTEDVLYFTLCKSLLGCPIQQVACGWDFTIILTKNGQVLSCGSNSFGQLG
Sbjct: 75   LNKDGQLGLGHTEDVLYFTLCKSLLGCPIQQVACGWDFTIILTKNGQVLSCGSNSFGQLG 134

Query: 410  VPHGPRRCVVPQAIEVQREKVVSIXXXXXXXXXXXXSGLVFQWGTGLASSGRRLCPGQTL 589
            VPHGPRRCVVPQAIEVQREKVVSI            SGLVFQWGTGLASSGRRLCPGQTL
Sbjct: 135  VPHGPRRCVVPQAIEVQREKVVSIAAGLRHALAATASGLVFQWGTGLASSGRRLCPGQTL 194

Query: 590  PLFLTAKEPSKVTGLENSQAVCVLAGSGHSASLTDAGELYVWGSNKHGQLASQAAFLPLP 769
            PLFLTAKEPSKVTGLENSQAVCVLAGSGHSASLTDAGELYVWGSNKHGQLASQAAFLPLP
Sbjct: 195  PLFLTAKEPSKVTGLENSQAVCVLAGSGHSASLTDAGELYVWGSNKHGQLASQAAFLPLP 254

Query: 770  QKIEAHRFQNEKVAAVWSGWTHLVAQTETGKVFTWGRADYGQLGRTLESPEGWKPKKQAS 949
            QKIEAHRFQNEKVAAVWSGWTHLVAQTETGKVFTWGRADYGQLGRTLESPEGWKPKKQAS
Sbjct: 255  QKIEAHRFQNEKVAAVWSGWTHLVAQTETGKVFTWGRADYGQLGRTLESPEGWKPKKQAS 314

Query: 950  SLPCSRPARSVPSSLPCLTGATEVSCGS 1033
            SLPCSRPARSVPSSLPCLTGATE  CG+
Sbjct: 315  SLPCSRPARSVPSSLPCLTGATEWFCGN 342



 Score = 53.1 bits (126), Expect = 3e-07
 Identities = 69/243 (28%), Positives = 96/243 (39%), Gaps = 6/243 (2%)
 Frame = +2

Query: 383  GSNSFGQLGVPHGPRRCVVPQAIEVQREKVVS-IXXXXXXXXXXXXSGLVFQWGTGLASS 559
            G+NS+GQLG+ H     +  Q  E  +   V  I             G +F    GL   
Sbjct: 21   GANSYGQLGLGHKEDVLLPQQLSEFCKPGCVKRITGGGGHSAIVTDQGSLFV--CGLNKD 78

Query: 560  GRRLCPGQTLPLFLTAKEPSKVTGLENSQAVCVLAGSGHSASLTDAGELYVWGSNKHGQL 739
            G+         L+ T  +   + G    Q  C   G   +  LT  G++   GSN  GQL
Sbjct: 79   GQLGLGHTEDVLYFTLCK--SLLGCPIQQVAC---GWDFTIILTKNGQVLSCGSNSFGQL 133

Query: 740  ASQAA--FLPLPQKIEAHRFQNEKVAAVWSGWTHLVAQTETGKVFTWGRADYGQLGRTLE 913
                      +PQ IE  R   EKV ++ +G  H +A T +G VF WG       GR L 
Sbjct: 134  GVPHGPRRCVVPQAIEVQR---EKVVSIAAGLRHALAATASGLVFQWGTG-LASSGRRL- 188

Query: 914  SPEGWKPKKQASSLPCSRPARSVPSSLPCLTGATEVS--CGSEHNLAVV-GGTCYSWGWN 1084
                        +LP    A+  PS +  L  +  V    GS H+ ++   G  Y WG N
Sbjct: 189  --------CPGQTLPLFLTAKE-PSKVTGLENSQAVCVLAGSGHSASLTDAGELYVWGSN 239

Query: 1085 EHG 1093
            +HG
Sbjct: 240  KHG 242


>ref|XP_003129377.2| PREDICTED: probable E3 ubiquitin-protein ligase HERC3-like [Sus
            scrofa].
          Length = 370

 Score =  134 bits (337), Expect = 1e-31
 Identities = 106/368 (28%), Positives = 162/368 (44%), Gaps = 5/368 (1%)
 Frame = +2

Query: 56   LFAWGANSYGQLGLG-HKEDVLLPQQLSEFCKPGCVKRITGGGGHSAIVTDQGSLFVCGL 232
            +  WG  S GQ G+  + + ++   Q+  F     VK +  GG HS  + + G ++ CGL
Sbjct: 1    MLCWGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGDHSVFLLEDGEVYTCGL 60

Query: 233  NKDGQLGLGHTEDVLYFTLCKSLLGCPIQQVACGWDFTIILTKNGQVLSCGSNSFGQLGV 412
            N  GQ  LGH  +        +L    I  VACG   ++ L+  GQ+ S G+ S GQLG+
Sbjct: 61   NTKGQ--LGHEREGNKPEQIGALADEHIVHVACGESHSLALSDRGQLFSWGAGSDGQLGL 118

Query: 413  PHGPRRCVVPQAIE-VQREKVVSIXXXXXXXXXXXXSGLVFQWGTGLASSGRRLCPGQTL 589
                    VP+ I+ + ++ ++ +             G  F WG    +S  +L  G+  
Sbjct: 119  MTTEESVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWG---KNSHGQLGLGKEF 175

Query: 590  PLFLTAKEPSKVTGLENSQAVCVLAGSGHSASLTDAGELYVWGSNKHGQLA-SQAAFLPL 766
            P   +   P +V  LE      V AG  HS +L+ +G ++ WG N  GQL  S       
Sbjct: 176  P---SQASPQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEEDRES 232

Query: 767  PQKIEAHRFQNEKVAAVWSGWTHLVAQTETGKVFTWGRADYGQLGRTLESPEGWKPKKQA 946
            P  ++  R Q  KV  +  G  H    T++G VFT+G    GQLG    + E   P++  
Sbjct: 233  PCHVKLLRAQ--KVVYISCGEEHTAVLTKSGGVFTFGAGSCGQLGHDSMNDE-VNPRRVL 289

Query: 947  SSLPCSRPARSVPSSLPCLTGATEVSCGSEHNLAVV--GGTCYSWGWNEHGMCGDGTEAN 1120
              +                +  T+++CG +H LA V   G  Y++G    G  G G   N
Sbjct: 290  ELMG---------------SEVTQIACGRQHTLAFVPSSGLIYAFGCGARGQLGTGHTCN 334

Query: 1121 VWTPKPVQ 1144
            V  P PV+
Sbjct: 335  VKCPSPVK 342



 Score = 95.9 bits (237), Expect = 4e-20
 Identities = 79/309 (25%), Positives = 122/309 (39%), Gaps = 6/309 (1%)
 Frame = +2

Query: 287  LCKSLLGCPIQQVACGWDFTIILTKNGQVLSCGSNSFGQLGVPHGPRRCVVPQAIEVQRE 466
            +C  +    +++VACG D ++ L ++G+V +CG N+ GQLG  H        Q   +  E
Sbjct: 27   VCGFISDRSVKEVACGGDHSVFLLEDGEVYTCGLNTKGQLG--HEREGNKPEQIGALADE 84

Query: 467  KVVSIXXXXXXXXXXXXSGLVFQWGTGLASSGRRLCPGQTLPLFLTAKE---PSKVTGLE 637
             +V +             G +F WG G  S G+       L L  T +    P  +  L 
Sbjct: 85   HIVHVACGESHSLALSDRGQLFSWGAG--SDGQ-------LGLMTTEESVAVPRLIQKLN 135

Query: 638  NSQAVCVLAGSGHSASLTDAGELYVWGSNKHGQLASQAAFLPLPQKIEAHRFQNEKVAAV 817
                + V  G+ H  +L   G+ + WG N HGQL     F            +   +A V
Sbjct: 136  QQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQV 195

Query: 818  WSGWTHLVAQTETGKVFTWGRADYGQLGRTLESPEGWKPKKQASSLPCSRPARSVPSSLP 997
             +G  H  A + +G VF WG  + GQLG + E                    R  P  + 
Sbjct: 196  AAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEED------------------RESPCHVK 237

Query: 998  CLTG--ATEVSCGSEHNLAVV-GGTCYSWGWNEHGMCGDGTEANVWTPKPVQALRSSSGL 1168
             L       +SCG EH   +   G  +++G    G  G  +  +   P+ V  L  S   
Sbjct: 238  LLRAQKVVYISCGEEHTAVLTKSGGVFTFGAGSCGQLGHDSMNDEVNPRRVLELMGSEVT 297

Query: 1169 RLGCGAGHS 1195
            ++ CG  H+
Sbjct: 298  QIACGRQHT 306



 Score = 66.6 bits (161), Expect = 3e-11
 Identities = 41/123 (33%), Positives = 62/123 (50%), Gaps = 1/123 (0%)
 Frame = +2

Query: 53  ALFAWGANSYGQLGLGHKEDVLLPQQLSEFCKPGCVKRITGGGGHSAIVTDQGSLFVCGL 232
           A+F WG N+ GQLGL  +ED   P  + +  +   V  I+ G  H+A++T  G +F  G 
Sbjct: 210 AVFGWGMNNAGQLGLSDEEDRESPCHV-KLLRAQKVVYISCGEEHTAVLTKSGGVFTFGA 268

Query: 233 NKDGQLGLGHTEDVLYFTLCKSLLGCPIQQVACGWDFTI-ILTKNGQVLSCGSNSFGQLG 409
              GQLG     D +       L+G  + Q+ACG   T+  +  +G + + G  + GQLG
Sbjct: 269 GSCGQLGHDSMNDEVNPRRVLELMGSEVTQIACGRQHTLAFVPSSGLIYAFGCGARGQLG 328

Query: 410 VPH 418
             H
Sbjct: 329 TGH 331


>ref|XP_003133446.2| PREDICTED: e3 ubiquitin-protein ligase HERC2-like [Sus scrofa].
          Length = 4292

 Score =  122 bits (306), Expect = 4e-28
 Identities = 115/390 (29%), Positives = 170/390 (43%), Gaps = 10/390 (2%)
 Frame = +2

Query: 56   LFAWGANSYGQLG--LGHKEDVLLPQQLSEFCKPGCVKRITGGGGHSAIVTDQGSLFVCG 229
            ++ WG N  GQLG   G K  V  P +     +P    ++ GG      VT  G L+  G
Sbjct: 3413 IYGWGHNHRGQLGGIEGAKVKVPTPCEALAALRP---VQLIGGEQTLFAVTADGKLYATG 3469

Query: 230  LNKDGQLGLGHTEDVLYFTLCKSLLGCPIQQVAC--GWDFTIILTKNGQVLSCGSNSFGQ 403
                G+LG+G TE V   TL +S+    I++VA   G    + L+  G+V S G    G+
Sbjct: 3470 YGAGGRLGIGGTESVSTPTLLESIQHVFIKKVAVNSGGKHCLALSSEGEVYSWGEAEDGK 3529

Query: 404  LGVPHGPRR-CVVPQAIEVQRE-KVVSIXXXXXXXXXXXXSGLVFQWGTG-LASSGRRLC 574
            LG  HG R  C  P+ IE  R  +VV +            +G ++ WG G     G    
Sbjct: 3530 LG--HGNRSPCDRPRVIESLRGIEVVDVAAGGAHSACVTAAGDLYTWGKGRYGRLGHSDS 3587

Query: 575  PGQTLPLFLTAKEPSKVTGLENSQAVCVLAGSGHSASL--TDAGELYVWGSNKHGQLASQ 748
              Q         +P  V  L+  + V V  GSG + +L  TD   ++ WG   +G+L   
Sbjct: 3588 EDQL--------KPKLVDALQGHRVVDVACGSGDAQTLCLTDDDTVWSWGDGDYGKLGRG 3639

Query: 749  AAF-LPLPQKIEAHRFQNEKVAAVWSGWTHLVAQTETGKVFTWGRADYGQLGRTLESPEG 925
             +    +P KI++       V  V  G    VA T++G V+TWG+ DY +LG    S + 
Sbjct: 3640 GSDGCKVPMKIDS--LTGLGVVKVECGSQFSVALTKSGAVYTWGKGDYHRLGHG--SDDH 3695

Query: 926  WKPKKQASSLPCSRPARSVPSSLPCLTGATEVSCGSEHNLAVVGGTCYSWGWNEHGMCGD 1105
             +  +Q   L   +       SL C+       C +E          Y+WG N+ G  GD
Sbjct: 3696 VRRPRQVQGLQGKKVIAIATGSLHCV-------CCTEDG-------SYTWGDNDEGQLGD 3741

Query: 1106 GTEANVWTPKPVQALRSSSGLRLGCGAGHS 1195
            GT   +  P+ V AL+     R+ CG+ H+
Sbjct: 3742 GTTNAIQRPRLVAALQGKKVNRVACGSAHT 3771



 Score =  119 bits (298), Expect = 4e-27
 Identities = 117/398 (29%), Positives = 167/398 (41%), Gaps = 16/398 (4%)
 Frame = +2

Query: 50   TALFAWGANSYGQLGLGHKEDVLLPQQLSEFCKPGCVKRITGGGGHSAIVTDQGSLFVCG 229
            T +F WG N   QLG G K   +     SE      V ++ GG      VT +G ++ CG
Sbjct: 2416 TKVFVWGLNDKDQLG-GLKGSKIKVPSFSETLSALNVVQVAGGSKSLFAVTVEGKVYACG 2474

Query: 230  LNKDGQLGLGHTEDVLYFTL-CKSLLGCPIQQVAC--GWDFTIILTKNGQVLSCGSNSFG 400
               +G+LGLG +   +       +L    +++VA   G      LT +G+V S G    G
Sbjct: 2475 EATNGRLGLGISSGTVPIPRQITALSSYVVKKVAVHSGGRHATALTVDGKVFSWGEGDDG 2534

Query: 401  QLGVPHGPR-RCVVPQAIEVQREKVV-SIXXXXXXXXXXXXSGLVFQWGTGLASSGRRLC 574
            +LG  H  R  C  P+ IE  + K +  I            SG ++ WG G      RL 
Sbjct: 2535 KLG--HFSRMNCDKPRLIEALKTKRIRDIACGSSHSAALTSSGELYTWGLGEYG---RLG 2589

Query: 575  PGQTLPLFLTAKEPSKVTGLENSQAVCVLAGS--GHSASLTDAGELYVWGSNKHGQLASQ 748
             G       T  +P  V  L   + + V  GS    + +LTD G ++ WG    G+L   
Sbjct: 2590 HGDNT----TQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFSWGDGDFGKLGRG 2645

Query: 749  AAF-LPLPQKIEAHRFQNEKVAAVWSGWTHLVAQTETGKVFTWGRADYGQLG-------R 904
             +    +PQ IE  R   + V  +  G    +A T++G V+TWG+ DY +LG       R
Sbjct: 2646 GSEGCNIPQNIE--RLNGQGVCQIECGAQFSLALTKSGVVWTWGKGDYFRLGHGSDVHVR 2703

Query: 905  TLESPEGWKPKKQASSLPCSRPARSVPSSLPCLTGATEVSCGSEHNLAVV-GGTCYSWGW 1081
              +  EG + KK                          V+ G+ H LAV   G  Y+WG 
Sbjct: 2704 KPQVVEGLRGKK-----------------------IVHVAVGALHCLAVTDAGQVYAWGD 2740

Query: 1082 NEHGMCGDGTEANVWTPKPVQALRSSSGLRLGCGAGHS 1195
            N+HG  G+GT      P  VQ L      R+ CG+ HS
Sbjct: 2741 NDHGQQGNGTTTVNRKPTLVQGLEGQKITRVACGSSHS 2778



 Score =  114 bits (284), Expect = 1e-25
 Identities = 88/268 (32%), Positives = 126/268 (47%), Gaps = 3/268 (1%)
 Frame = +2

Query: 56   LFAWGANSYGQLGLGHKEDVLLPQQLSEFCKPGCVKRITGGGGHSAIVTDQGSLFVCGLN 235
            +F+WG    G+LG   + +   P+ L E  K   ++ I  G  HSA +T  G L+  GL 
Sbjct: 2525 VFSWGEGDDGKLGHFSRMNCDKPR-LIEALKTKRIRDIACGSSHSAALTSSGELYTWGLG 2583

Query: 236  KDGQLGLGHTEDVLYFTLCKSLLGCPIQQVACGWDF--TIILTKNGQVLSCGSNSFGQLG 409
            + G+LG G     L   + K LLG  + QVACG     T+ LT  G V S G   FG+LG
Sbjct: 2584 EYGRLGHGDNTTQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFSWGDGDFGKLG 2643

Query: 410  VPHGPRRCVVPQAIE-VQREKVVSIXXXXXXXXXXXXSGLVFQWGTGLASSGRRLCPGQT 586
               G   C +PQ IE +  + V  I            SG+V+ WG G      RL  G  
Sbjct: 2644 -RGGSEGCNIPQNIERLNGQGVCQIECGAQFSLALTKSGVVWTWGKG---DYFRLGHGSD 2699

Query: 587  LPLFLTAKEPSKVTGLENSQAVCVLAGSGHSASLTDAGELYVWGSNKHGQLASQAAFLPL 766
            + +    ++P  V GL   + V V  G+ H  ++TDAG++Y WG N HGQ  +    +  
Sbjct: 2700 VHV----RKPQVVEGLRGKKIVHVAVGALHCLAVTDAGQVYAWGDNDHGQQGNGTTTVNR 2755

Query: 767  PQKIEAHRFQNEKVAAVWSGWTHLVAQT 850
               +     + +K+  V  G +H VA T
Sbjct: 2756 KPTL-VQGLEGQKITRVACGSSHSVAWT 2782



 Score =  108 bits (269), Expect = 8e-24
 Identities = 89/326 (27%), Positives = 143/326 (43%), Gaps = 9/326 (2%)
 Frame = +2

Query: 242  GQLGLGHTEDVLYFTLCKSLLGCPIQQVACGWDFTIILTKNGQVLSCGSNSFGQLGVPHG 421
            G +G  +  +V+    C+ L    + Q+AC     +IL++NG+V +   NS         
Sbjct: 430  GLIGWKYYANVIGPIQCEGLANLGVTQIACAEKRFLILSRNGRVYTQAYNS--------- 480

Query: 422  PRRCVVPQAIE-VQREKVVSIXXXXXXXXXXXXS--GLVFQWGTGLASSGRRLCPGQTLP 592
                + PQ ++ +    ++ I            +  G V+ WG G    G RL  G T+P
Sbjct: 481  --DTLAPQLVQGLASRNIIKIAAHSDGHHYLALAATGEVYSWGCG---DGGRLGHGDTVP 535

Query: 593  LFLTAKEPSKVTGLENSQA----VCVLAGSGHSASLTDAGELYVWGSNKHGQLA-SQAAF 757
            L    +EP  ++     QA    V +  GS +SA++T  GELY WG   +G+L    +  
Sbjct: 536  L----EEPKVISAFSGKQAGKHVVHIACGSTYSAAITAEGELYTWGRGNYGRLGHGSSED 591

Query: 758  LPLPQKIEAHRFQNEKVAAVWSGWTHLVAQTETGKVFTWGRADYGQLGRTLESPEGWKPK 937
              +P  +   +       A  SG    +A TE G+V++WG  DYG+LGR     +G K  
Sbjct: 592  EAIPMLVAGLKGLKVIDVACGSGDAQTLAVTENGQVWSWGDGDYGKLGR--GGSDGCKTP 649

Query: 938  KQASSLPCSRPARSVPSSLPCLTGATEVSCGSEHNLAVV-GGTCYSWGWNEHGMCGDGTE 1114
            K    L                    +V CGS+ ++A+   G  YSWG  ++   G GTE
Sbjct: 650  KLIEKLQD--------------LDVVKVRCGSQFSIALTKDGQVYSWGKGDNQRLGHGTE 695

Query: 1115 ANVWTPKPVQALRSSSGLRLGCGAGH 1192
             +V  PK ++ L+    + +  G+ H
Sbjct: 696  EHVRYPKLLEGLQGKKVIDVAAGSTH 721



 Score = 97.8 bits (242), Expect = 1e-20
 Identities = 73/233 (31%), Positives = 108/233 (46%), Gaps = 6/233 (2%)
 Frame = +2

Query: 56   LFAWGANSYGQLGLGHKEDVLLPQQLSEFCKPGCVKRITG---GGGHSAIVTDQGSLFVC 226
            +++WG    G+LG G    +  P+ +S F      K +     G  +SA +T +G L+  
Sbjct: 517  VYSWGCGDGGRLGHGDTVPLEEPKVISAFSGKQAGKHVVHIACGSTYSAAITAEGELYTW 576

Query: 227  GLNKDGQLGLGHTEDVLYFTLCKSLLGCPIQQVACGWD--FTIILTKNGQVLSCGSNSFG 400
            G    G+LG G +ED     L   L G  +  VACG     T+ +T+NGQV S G   +G
Sbjct: 577  GRGNYGRLGHGSSEDEAIPMLVAGLKGLKVIDVACGSGDAQTLAVTENGQVWSWGDGDYG 636

Query: 401  QLGVPHGPRRCVVPQAIE-VQREKVVSIXXXXXXXXXXXXSGLVFQWGTGLASSGRRLCP 577
            +LG   G   C  P+ IE +Q   VV +             G V+ WG G     +RL  
Sbjct: 637  KLG-RGGSDGCKTPKLIEKLQDLDVVKVRCGSQFSIALTKDGQVYSWGKG---DNQRLGH 692

Query: 578  GQTLPLFLTAKEPSKVTGLENSQAVCVLAGSGHSASLTDAGELYVWGSNKHGQ 736
            G    +    + P  + GL+  + + V AGS H  +LT+  E++ WGSN   Q
Sbjct: 693  GTEEHV----RYPKLLEGLQGKKVIDVAAGSTHCLALTEDSEVHSWGSNDQCQ 741



 Score = 95.5 bits (236), Expect = 5e-20
 Identities = 92/343 (26%), Positives = 150/343 (43%), Gaps = 12/343 (3%)
 Frame = +2

Query: 56   LFAWGANSYGQLGLGHKEDVL-LPQQLSEFCKPGCVKRIT--GGGGHSAIVTDQGSLFVC 226
            ++A G  + G+LGLG     + +P+Q++       VK++    GG H+  +T  G +F  
Sbjct: 2470 VYACGEATNGRLGLGISSGTVPIPRQITALSSY-VVKKVAVHSGGRHATALTVDGKVFSW 2528

Query: 227  GLNKDGQLGLGHTEDVLYFTLCKSLLGCPIQQVACGWDFTIILTKNGQVLSCGSNSFGQL 406
            G   DG+LG     +     L ++L    I+ +ACG   +  LT +G++ + G   +G+L
Sbjct: 2529 GEGDDGKLGHFSRMNCDKPRLIEALKTKRIRDIACGSSHSAALTSSGELYTWGLGEYGRL 2588

Query: 407  GVPHGPRRCVV-PQAIEV---QREKVVSIXXXXXXXXXXXXSGLVFQWGTG-LASSGRRL 571
            G  HG     + P+ ++V    R   V+              GLVF WG G     GR  
Sbjct: 2589 G--HGDNTTQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFSWGDGDFGKLGRGG 2646

Query: 572  CPGQTLPLFLTAKEPSKVTGLENSQAVCVL-AGSGHSASLTDAGELYVWGSNKHGQLASQ 748
              G  +P  +            N Q VC +  G+  S +LT +G ++ WG   + +L   
Sbjct: 2647 SEGCNIPQNIERL---------NGQGVCQIECGAQFSLALTKSGVVWTWGKGDYFRLGHG 2697

Query: 749  A-AFLPLPQKIEAHRFQNEKVAAVWSGWTHLVAQTETGKVFTWGRADYGQLGRTLESPEG 925
            +   +  PQ +E  R   +K+  V  G  H +A T+ G+V+ WG  D+GQ G    +   
Sbjct: 2698 SDVHVRKPQVVEGLR--GKKIVHVAVGALHCLAVTDAGQVYAWGDNDHGQQGNGTTT--- 2752

Query: 926  WKPKKQASSLPCSRPARSVPSSLPCLTGA--TEVSCGSEHNLA 1048
                               P+ +  L G   T V+CGS H++A
Sbjct: 2753 ---------------VNRKPTLVQGLEGQKITRVACGSSHSVA 2780



 Score = 79.3 bits (194), Expect = 4e-15
 Identities = 84/331 (25%), Positives = 136/331 (41%), Gaps = 46/331 (13%)
 Frame = +2

Query: 338  DFTIILTKNGQVLSCGSNSFGQLGVPHGPRRCVVPQAIEVQREKVVSIXXXXXXXXXXXX 517
            D+T+    +G +   G N  GQLG   G +  V      +   + V +            
Sbjct: 3402 DWTLSAGGSGTIYGWGHNHRGQLGGIEGAKVKVPTPCEALAALRPVQLIGGEQTLFAVTA 3461

Query: 518  SGLVFQWGTGLASSGRRLCPGQTLPLFLTAKEPSKVTGLENSQ-----AVCVLAGSGHSA 682
             G ++  G G   +G RL  G T       +  S  T LE+ Q      V V +G  H  
Sbjct: 3462 DGKLYATGYG---AGGRLGIGGT-------ESVSTPTLLESIQHVFIKKVAVNSGGKHCL 3511

Query: 683  SLTDAGELYVWGSNKHGQLA-SQAAFLPLPQKIEAHRFQNEKVAAVWSGWTHLVAQTETG 859
            +L+  GE+Y WG  + G+L     +    P+ IE+ R    +V  V +G  H    T  G
Sbjct: 3512 ALSSEGEVYSWGEAEDGKLGHGNRSPCDRPRVIESLR--GIEVVDVAAGGAHSACVTAAG 3569

Query: 860  KVFTWGRADYGQLGRTLESPEGWKPK-------KQASSLPC-SRPARS------------ 979
             ++TWG+  YG+LG + +S +  KPK        +   + C S  A++            
Sbjct: 3570 DLYTWGKGRYGRLGHS-DSEDQLKPKLVDALQGHRVVDVACGSGDAQTLCLTDDDTVWSW 3628

Query: 980  -----------------VPSSLPCLT--GATEVSCGSEHNLAVV-GGTCYSWGWNEHGMC 1099
                             VP  +  LT  G  +V CGS+ ++A+   G  Y+WG  ++   
Sbjct: 3629 GDGDYGKLGRGGSDGCKVPMKIDSLTGLGVVKVECGSQFSVALTKSGAVYTWGKGDYHRL 3688

Query: 1100 GDGTEANVWTPKPVQALRSSSGLRLGCGAGH 1192
            G G++ +V  P+ VQ L+    + +  G+ H
Sbjct: 3689 GHGSDDHVRRPRQVQGLQGKKVIAIATGSLH 3719



 Score = 77.4 bits (189), Expect = 2e-14
 Identities = 73/295 (24%), Positives = 118/295 (40%), Gaps = 9/295 (3%)
 Frame = +2

Query: 101  HKEDVLLPQQLSEFCKPGCVKRITGGGGHSAI-VTDQGSLFVCGLNKDGQLGLGHT---- 265
            +  D L PQ +        +K      GH  + +   G ++  G    G+LG G T    
Sbjct: 478  YNSDTLAPQLVQGLASRNIIKIAAHSDGHHYLALAATGEVYSWGCGDGGRLGHGDTVPLE 537

Query: 266  EDVLYFTLCKSLLGCPIQQVACGWDFTIILTKNGQVLSCGSNSFGQLGVPHGPRRCVVPQ 445
            E  +         G  +  +ACG  ++  +T  G++ + G  ++G+LG        +   
Sbjct: 538  EPKVISAFSGKQAGKHVVHIACGSTYSAAITAEGELYTWGRGNYGRLGHGSSEDEAIPML 597

Query: 446  AIEVQREKVVSIXXXXXXXXXXXXS--GLVFQWGTG-LASSGRRLCPGQTLPLFLTAKEP 616
               ++  KV+ +            +  G V+ WG G     GR    G         K P
Sbjct: 598  VAGLKGLKVIDVACGSGDAQTLAVTENGQVWSWGDGDYGKLGRGGSDG--------CKTP 649

Query: 617  SKVTGLENSQAVCVLAGSGHSASLTDAGELYVWGSNKHGQLA-SQAAFLPLPQKIEAHRF 793
              +  L++   V V  GS  S +LT  G++Y WG   + +L       +  P+ +E    
Sbjct: 650  KLIEKLQDLDVVKVRCGSQFSIALTKDGQVYSWGKGDNQRLGHGTEEHVRYPKLLEG--L 707

Query: 794  QNEKVAAVWSGWTHLVAQTETGKVFTWGRADYGQLGRTLESPEGWKPKKQASSLP 958
            Q +KV  V +G TH +A TE  +V +WG  D  Q   TL        K + S+LP
Sbjct: 708  QGKKVIDVAAGSTHCLALTEDSEVHSWGSNDQCQHFDTLR-----VTKPEPSALP 757



 Score = 72.4 bits (176), Expect = 5e-13
 Identities = 61/212 (28%), Positives = 92/212 (43%), Gaps = 3/212 (1%)
 Frame = +2

Query: 56   LFAWGANSYGQLGLGHKEDVLLPQQLSEFCKPGCVKRITGGGGHSAI-VTDQGSLFVCGL 232
            L+ WG  +YG+LG G  ED  +P  ++       +    G G    + VT+ G ++  G 
Sbjct: 573  LYTWGRGNYGRLGHGSSEDEAIPMLVAGLKGLKVIDVACGSGDAQTLAVTENGQVWSWGD 632

Query: 233  NKDGQLGLGHTEDVLYFTLCKSLLGCPIQQVACGWDFTIILTKNGQVLSCGSNSFGQLGV 412
               G+LG G ++      L + L    + +V CG  F+I LTK+GQV S G     +LG 
Sbjct: 633  GDYGKLGRGGSDGCKTPKLIEKLQDLDVVKVRCGSQFSIALTKDGQVYSWGKGDNQRLG- 691

Query: 413  PHGPRRCV-VPQAIE-VQREKVVSIXXXXXXXXXXXXSGLVFQWGTGLASSGRRLCPGQT 586
             HG    V  P+ +E +Q +KV+ +               V  WG     S  +     T
Sbjct: 692  -HGTEEHVRYPKLLEGLQGKKVIDVAAGSTHCLALTEDSEVHSWG-----SNDQCQHFDT 745

Query: 587  LPLFLTAKEPSKVTGLENSQAVCVLAGSGHSA 682
            L   +T  EPS + GL+    V +  G    A
Sbjct: 746  LR--VTKPEPSALPGLDTKHIVGIACGPAQKA 775



 Score = 70.1 bits (170), Expect = 2e-12
 Identities = 58/204 (28%), Positives = 89/204 (43%), Gaps = 10/204 (4%)
 Frame = +2

Query: 614  PSKVTGLENSQAVCVLAGSG--HSASLTDAGELYVWGSNKHGQLA-SQAAFLPLPQKIEA 784
            P  V GL +   + + A S   H  +L   GE+Y WG    G+L       L  P+ I A
Sbjct: 485  PQLVQGLASRNIIKIAAHSDGHHYLALAATGEVYSWGCGDGGRLGHGDTVPLEEPKVISA 544

Query: 785  H--RFQNEKVAAVWSGWTHLVAQTETGKVFTWGRADYGQLGRTLESPEGWKPKKQASSLP 958
               +   + V  +  G T+  A T  G+++TWGR +YG+LG      E            
Sbjct: 545  FSGKQAGKHVVHIACGSTYSAAITAEGELYTWGRGNYGRLGHGSSEDE------------ 592

Query: 959  CSRPARSVPSSLPCLTG--ATEVSCGS--EHNLAVV-GGTCYSWGWNEHGMCGDGTEANV 1123
                  ++P  +  L G    +V+CGS     LAV   G  +SWG  ++G  G G     
Sbjct: 593  ------AIPMLVAGLKGLKVIDVACGSGDAQTLAVTENGQVWSWGDGDYGKLGRGGSDGC 646

Query: 1124 WTPKPVQALRSSSGLRLGCGAGHS 1195
             TPK ++ L+    +++ CG+  S
Sbjct: 647  KTPKLIEKLQDLDVVKVRCGSQFS 670


>ref|XP_003357882.1| PREDICTED: RCC1 and BTB domain-containing protein 1 [Sus scrofa].
          Length = 531

 Score =  106 bits (264), Expect = 3e-23
 Identities = 82/286 (28%), Positives = 131/286 (45%), Gaps = 11/286 (3%)
 Frame = +2

Query: 56  LFAWGANSYGQLGLGHKEDVLLPQQLSEFCKPGCVKRITGGGGHSAIVTDQGSLFVCGLN 235
           +F +G N    LG G  +  L+P++L   C         G G H  + T+ G ++  G N
Sbjct: 43  VFVFGLNYSNCLGTGDNQSTLVPKKLEALCGKKIKSLSYGSGPHVLLSTEDGVVYAWGHN 102

Query: 236 KDGQLGLGHT-EDVLYFTLCKSLLGCPIQQVACGWDFTIILTKNGQVLSCGSNSFGQLG- 409
              QLG G T + +    +C +LL   + +VACG   ++ L  +G+V + G N+ GQ+G 
Sbjct: 103 GYSQLGNGTTNQGIAPIQVCTNLLIKQVVEVACGSHHSMALAADGEVFAWGYNNCGQVGS 162

Query: 410 --VPHGPRRCVVPQAIEVQREKVVSIXXXXXXXXXXXXSGLVFQWG------TGLASSGR 565
               + P    V   + ++R  VVSI            +G V+ WG       GL ++G 
Sbjct: 163 GSTANQPTPRKVTNCLHIKR--VVSIACGQTSSMAVLDNGEVYGWGYNGNGQLGLGNNGN 220

Query: 566 RLCPGQTLPLFLTAKEPSKVTGLENSQAVCVLAGSGHSASLTDAGELYVWGSNKHGQLAS 745
           +L              P +V  L +     ++ G  H+ +LTD G LY WG+N +GQL +
Sbjct: 221 QL-------------TPVRVAALHSVCVNQIVCGYAHTLALTDEGLLYAWGANTYGQLGT 267

Query: 746 -QAAFLPLPQKIEAHRFQNEKVAAVWSGWTHLVAQTETGKVFTWGR 880
                L  P  I   + +  ++AA  S  T   A+T+ G V+ WG+
Sbjct: 268 GNKNNLLSPAHIMVEKERVVEIAACHSAHTS-AAKTQGGHVYMWGQ 312



 Score = 80.5 bits (197), Expect = 2e-15
 Identities = 80/275 (29%), Positives = 122/275 (44%), Gaps = 12/275 (4%)
 Frame = +2

Query: 113 VLLPQQLSEFCKPGCVKRITGGGGHSAI-VTDQGSLFVCGLNKDGQLGLGHTEDVLYFTL 289
           +L PQ+++   K  CV    G   + A+ VTD   +FV GLN    LG G  +  L    
Sbjct: 12  LLSPQEIASIRK-ACV---FGTSANEALYVTDNDEVFVFGLNYSNCLGTGDNQSTLVPKK 67

Query: 290 CKSLLGCPIQQVACGWDFTIIL-TKNGQVLSCGSNSFGQLGVPHGPRR---CVVPQAIEV 457
            ++L G  I+ ++ G    ++L T++G V + G N + QLG  +G        +     +
Sbjct: 68  LEALCGKKIKSLSYGSGPHVLLSTEDGVVYAWGHNGYSQLG--NGTTNQGIAPIQVCTNL 125

Query: 458 QREKVVSIXXXXXXXXXXXXSGLVFQWG---TGLASSGRRLCPGQTLPLFLTAKEPS--K 622
             ++VV +             G VF WG    G   SG             TA +P+  K
Sbjct: 126 LIKQVVEVACGSHHSMALAADGEVFAWGYNNCGQVGSGS------------TANQPTPRK 173

Query: 623 VTG-LENSQAVCVLAGSGHSASLTDAGELYVWGSNKHGQLASQAAFLPL-PQKIEAHRFQ 796
           VT  L   + V +  G   S ++ D GE+Y WG N +GQL        L P ++ A    
Sbjct: 174 VTNCLHIKRVVSIACGQTSSMAVLDNGEVYGWGYNGNGQLGLGNNGNQLTPVRVAA--LH 231

Query: 797 NEKVAAVWSGWTHLVAQTETGKVFTWGRADYGQLG 901
           +  V  +  G+ H +A T+ G ++ WG   YGQLG
Sbjct: 232 SVCVNQIVCGYAHTLALTDEGLLYAWGANTYGQLG 266



 Score = 80.1 bits (196), Expect = 2e-15
 Identities = 55/182 (30%), Positives = 87/182 (47%), Gaps = 2/182 (1%)
 Frame = +2

Query: 56  LFAWGANSYGQLGLGHKEDVLLPQQLSEFCKPGCVKRITGGGGHSAIVTDQGSLFVCGLN 235
           +FAWG N+ GQ+G G   +   P++++       V  I  G   S  V D G ++  G N
Sbjct: 149 VFAWGYNNCGQVGSGSTANQPTPRKVTNCLHIKRVVSIACGQTSSMAVLDNGEVYGWGYN 208

Query: 236 KDGQLGLGHTEDVLYFTLCKSLLGCPIQQVACGWDFTIILTKNGQVLSCGSNSFGQLGVP 415
            +GQLGLG+  + L      +L    + Q+ CG+  T+ LT  G + + G+N++GQLG  
Sbjct: 209 GNGQLGLGNNGNQLTPVRVAALHSVCVNQIVCGYAHTLALTDEGLLYAWGANTYGQLGTG 268

Query: 416 HGPRRCVVPQAIEVQREKVVSIXXXXXXXXXXXXS--GLVFQWGTGLASSGRRLCPGQTL 589
           +     + P  I V++E+VV I            +  G V+ WG          C GQ++
Sbjct: 269 N-KNNLLSPAHIMVEKERVVEIAACHSAHTSAAKTQGGHVYMWGQ---------CRGQSV 318

Query: 590 PL 595
            L
Sbjct: 319 TL 320



 Score = 71.6 bits (174), Expect = 8e-13
 Identities = 56/198 (28%), Positives = 82/198 (41%), Gaps = 4/198 (2%)
 Frame = +2

Query: 614  PSKVTGLENSQAVCVLAGSG-HSASLTDAGELYVWGSNKHGQLASQAAFLPLPQKIEAHR 790
            P K+  L   +   +  GSG H    T+ G +Y WG N + QL +      +        
Sbjct: 65   PKKLEALCGKKIKSLSYGSGPHVLLSTEDGVVYAWGHNGYSQLGNGTTNQGIAPIQVCTN 124

Query: 791  FQNEKVAAVWSGWTHLVAQTETGKVFTWGRADYGQLGR--TLESPEGWKPKKQASSLPCS 964
               ++V  V  G  H +A    G+VF WG  + GQ+G   T   P    P+K  + L   
Sbjct: 125  LLIKQVVEVACGSHHSMALAADGEVFAWGYNNCGQVGSGSTANQPT---PRKVTNCLHIK 181

Query: 965  RPARSVPSSLPCLTGATEVSCGSEHNLAVV-GGTCYSWGWNEHGMCGDGTEANVWTPKPV 1141
            R                 ++CG   ++AV+  G  Y WG+N +G  G G   N  TP  V
Sbjct: 182  R--------------VVSIACGQTSSMAVLDNGEVYGWGYNGNGQLGLGNNGNQLTPVRV 227

Query: 1142 QALRSSSGLRLGCGAGHS 1195
             AL S    ++ CG  H+
Sbjct: 228  AALHSVCVNQIVCGYAHT 245


>ref|XP_003135065.2| PREDICTED: hypothetical protein LOC100511730 [Sus scrofa].
          Length = 1224

 Score =  105 bits (261), Expect = 7e-23
 Identities = 87/290 (30%), Positives = 138/290 (47%), Gaps = 3/290 (1%)
 Frame = +2

Query: 56  LFAWGANSYGQLGLGHKEDVLLPQQLSEFCKPGCVKRITGGGGHSAIVTDQGSLFVCGLN 235
           LF +G+N++GQLGLG K  V  P  +    KP  VK    G  H+ I T+ G ++  G N
Sbjct: 56  LFMFGSNNWGQLGLGSKSTVDKPTCVKAL-KPEKVKFAACGRNHTLISTEGGKVYAAGGN 114

Query: 236 KDGQLGLGHTEDVLYFTLCKSLLG-CPIQQVACGWDFTIILTKNGQVLSCGSNSFGQLGV 412
            +GQLGLG TE+   F +         I+Q++ G + +  LT++G++   G NS GQ+G+
Sbjct: 115 NEGQLGLGDTEERNTFHVINFFTSQHKIKQLSAGSNTSAALTEDGELFMWGDNSEGQIGL 174

Query: 413 PHGPRRCVVPQAIEVQREKVVSIXXXXXXXXXXXXSGLVFQWGTGLASSGRRLCPGQTLP 592
            +    CV  Q   V   K +S             S  V   G  L + G   C    LP
Sbjct: 175 QNMTSICVPHQ---VTIGKPIS-----WISCGYYHSAFVTTEGE-LYTFGEPECGKLGLP 225

Query: 593 --LFLTAKEPSKVTGLENSQAVCVLAGSGHSASLTDAGELYVWGSNKHGQLASQAAFLPL 766
             L +  + P  V G+   + + V  G GH+ +LT+   +YV+G  + GQL         
Sbjct: 226 RKLLVNHRVPQLVPGIP-EKVIQVACGGGHTVALTE-NAVYVFGLGQFGQLGLGTFIFET 283

Query: 767 PQKIEAHRFQNEKVAAVWSGWTHLVAQTETGKVFTWGRADYGQLGRTLES 916
            +       +++K++ +  G  H    T+ G ++T+G   +G+LG  LE+
Sbjct: 284 SEPKVIDNIKDQKISYISCGENHTALITDLGLMYTFGDGRHGKLGLGLEN 333



 Score = 91.3 bits (225), Expect = 1e-18
 Identities = 94/335 (28%), Positives = 133/335 (39%), Gaps = 22/335 (6%)
 Frame = +2

Query: 176  GGGHSAIVTDQGSLFVCGLNKDGQLGLGHTEDVLYFTLCKSLLGCPIQQVACGWDFTIIL 355
            G  H+AI+T    LF+ G N  GQLGLG    V   T  K+L    ++  ACG + T+I 
Sbjct: 43   GDEHTAIITGNNKLFMFGSNNWGQLGLGSKSTVDKPTCVKALKPEKVKFAACGRNHTLIS 102

Query: 356  TKNGQVLSCGSNSFGQLGVPHGPRRCVVPQA-IEVQREKVVSIXXXXXXXXXXXXSGLVF 532
            T+ G+V + G N+ GQLG+     R           + K+  +             G +F
Sbjct: 103  TEGGKVYAAGGNNEGQLGLGDTEERNTFHVINFFTSQHKIKQLSAGSNTSAALTEDGELF 162

Query: 533  QWGTGLASSGRRLCPGQTLPLFLTAKEPSKVTGLENSQAVCV-------------LAGSG 673
             WG    S G+                     GL+N  ++CV               G  
Sbjct: 163  MWGDN--SEGQ--------------------IGLQNMTSICVPHQVTIGKPISWISCGYY 200

Query: 674  HSASLTDAGELYVWGSNKHGQLASQAAFLPLPQKIEA-HRFQN------EKVAAVWSGWT 832
            HSA +T  GELY +G  + G+L        LP+K+   HR         EKV  V  G  
Sbjct: 201  HSAFVTTEGELYTFGEPECGKLG-------LPRKLLVNHRVPQLVPGIPEKVIQVACGGG 253

Query: 833  HLVAQTETGKVFTWGRADYGQLGRTLESPEGWKPKKQASSLPCSRPARSVPSSLPCLTGA 1012
            H VA TE   V+ +G   +GQLG      E  +P K   ++   +               
Sbjct: 254  HTVALTENA-VYVFGLGQFGQLGLGTFIFETSEP-KVIDNIKDQK--------------I 297

Query: 1013 TEVSCGSEHNLAVVG-GTCYSWGWNEHGMCGDGTE 1114
            + +SCG  H   +   G  Y++G   HG  G G E
Sbjct: 298  SYISCGENHTALITDLGLMYTFGDGRHGKLGLGLE 332



 Score = 52.8 bits (125), Expect = 4e-07
 Identities = 32/96 (33%), Positives = 50/96 (52%), Gaps = 2/96 (2%)
 Frame = +2

Query: 53  ALFAWGANSYGQLGLGHKEDVLLPQQLSEFCKPGCVKRITGGGGHSAIVTDQGSLFVCGL 232
           A++ +G   +GQLGLG         ++ +  K   +  I+ G  H+A++TD G ++  G 
Sbjct: 262 AVYVFGLGQFGQLGLGTFIFETSEPKVIDNIKDQKISYISCGENHTALITDLGLMYTFGD 321

Query: 233 NKDGQLGLGHTEDVLYF--TLCKSLLGCPIQQVACG 334
            + G+LGLG       F  TLC + L   +Q VACG
Sbjct: 322 GRHGKLGLGLENFTNQFIPTLCSNFLRFIVQLVACG 357


>ref|XP_001928937.1| PREDICTED: RCC1 and BTB domain-containing protein 2 isoform 1 [Sus
           scrofa].
          Length = 568

 Score =  103 bits (257), Expect = 2e-22
 Identities = 81/287 (28%), Positives = 128/287 (44%), Gaps = 12/287 (4%)
 Frame = +2

Query: 56  LFAWGANSYGQLGLGHKEDVLLPQQLSEFCKPGCVKRITGGGGHSAIVTDQGSLFVCGLN 235
           +F  G N  G LGLG  +  + P++L             G G H  + T +G +F  G N
Sbjct: 84  IFVLGTNCCGCLGLGDVQSTIEPRRLDSLSGKKIACLSYGSGPHVVLATTEGEVFTWGHN 143

Query: 236 KDGQLGLGHTEDVLY-FTLCKSLLGCPIQQVACGWDFTIILTKNGQVLSCGSNSFGQLGV 412
              QLG G T   L    +  +L    + +VACG   +++LT +G+V + G N+ GQ+G 
Sbjct: 144 AYSQLGNGTTNHGLVPCHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGS 203

Query: 413 PHGPRRCVVPQAIE--VQREKVVSIXXXXXXXXXXXXSGLVFQWG------TGLASSGRR 568
                +  +P+ +   +Q + VV+I            +G V+ WG       GL S G +
Sbjct: 204 GSTANQ-PIPRRVTGCLQNKTVVNIACGQMCSMAVVDTGEVYVWGYNGNGQLGLGSGGNQ 262

Query: 569 LCPGQTLPLFLTAKEPSKVTGLENSQAVCVLAGSGHSASLTDAGELYVWGSNKHGQLAS- 745
                          P ++  L+  +   V  G  H+  LTD G++Y WG+N +GQL + 
Sbjct: 263 -------------PTPCRIAALQGIRVQRVACGYAHTLVLTDEGQVYAWGANSYGQLGTG 309

Query: 746 --QAAFLPLPQKIEAHRFQNEKVAAVWSGWTHLVAQTETGKVFTWGR 880
                  P P  +E  R    ++AA  S  T   A+T+ G V+ WG+
Sbjct: 310 NKSNQSYPTPVIVEKDRI--IEIAACHSAHTS-AAKTQGGHVYMWGQ 353



 Score = 97.4 bits (241), Expect = 1e-20
 Identities = 80/266 (30%), Positives = 120/266 (45%), Gaps = 12/266 (4%)
 Frame = +2

Query: 167 ITGGGGHSAIVTD-QGSLFVCGLNKDGQLGLGHTEDVLYFTLCKSLLGCPIQQVACGWDF 343
           + G  G+  + T     +FV G N  G LGLG  +  +      SL G  I  ++ G   
Sbjct: 67  VFGSAGNEVLYTTVNDEIFVLGTNCCGCLGLGDVQSTIEPRRLDSLSGKKIACLSYGSGP 126

Query: 344 TIIL-TKNGQVLSCGSNSFGQLG---VPHGPRRCVVPQAIEVQREKVVSIXXXXXXXXXX 511
            ++L T  G+V + G N++ QLG     HG   C +  +  +  ++V+ +          
Sbjct: 127 HVVLATTEGEVFTWGHNAYSQLGNGTTNHGLVPCHI--STNLSNKQVIEVACGSYHSLVL 184

Query: 512 XXSGLVFQWG---TGLASSGRRLCPGQTLPLFLTAKEP--SKVTG-LENSQAVCVLAGSG 673
              G VF WG   +G   SG             TA +P   +VTG L+N   V +  G  
Sbjct: 185 TSDGEVFAWGYNNSGQVGSGS------------TANQPIPRRVTGCLQNKTVVNIACGQM 232

Query: 674 HSASLTDAGELYVWGSNKHGQLA-SQAAFLPLPQKIEAHRFQNEKVAAVWSGWTHLVAQT 850
            S ++ D GE+YVWG N +GQL        P P +I A   Q  +V  V  G+ H +  T
Sbjct: 233 CSMAVVDTGEVYVWGYNGNGQLGLGSGGNQPTPCRIAA--LQGIRVQRVACGYAHTLVLT 290

Query: 851 ETGKVFTWGRADYGQLGRTLESPEGW 928
           + G+V+ WG   YGQLG   +S + +
Sbjct: 291 DEGQVYAWGANSYGQLGTGNKSNQSY 316



 Score = 85.5 bits (210), Expect = 6e-17
 Identities = 74/269 (27%), Positives = 111/269 (41%), Gaps = 7/269 (2%)
 Frame = +2

Query: 356  TKNGQVLSCGSNSFGQLGVPHGPRRCVVPQAIEVQREKVVSIXXXXXXXXXXXXS--GLV 529
            T N ++   G+N  G LG+    +  + P+ ++    K ++             +  G V
Sbjct: 79   TVNDEIFVLGTNCCGCLGLGD-VQSTIEPRRLDSLSGKKIACLSYGSGPHVVLATTEGEV 137

Query: 530  FQWGTGLASS-GRRLCPGQTLPLFLTAKEPSKVTGLENSQAVCVLAGSGHSASLTDAGEL 706
            F WG    S  G        +P  ++       T L N Q + V  GS HS  LT  GE+
Sbjct: 138  FTWGHNAYSQLGNGTTNHGLVPCHIS-------TNLSNKQVIEVACGSYHSLVLTSDGEV 190

Query: 707  YVWGSNKHGQLAS-QAAFLPLPQKIEAHRFQNEKVAAVWSGWTHLVAQTETGKVFTWGRA 883
            + WG N  GQ+ S   A  P+P+++     QN+ V  +  G    +A  +TG+V+ WG  
Sbjct: 191  FAWGYNNSGQVGSGSTANQPIPRRVTGC-LQNKTVVNIACGQMCSMAVVDTGEVYVWGYN 249

Query: 884  DYGQLGRTLESPEGWKPKKQASSLPCSRPARSVPSSLPCLTG--ATEVSCGSEHNLAVVG 1057
              GQLG                    S   +  P  +  L G     V+CG  H L +  
Sbjct: 250  GNGQLGLG------------------SGGNQPTPCRIAALQGIRVQRVACGYAHTLVLTD 291

Query: 1058 -GTCYSWGWNEHGMCGDGTEANVWTPKPV 1141
             G  Y+WG N +G  G G ++N   P PV
Sbjct: 292  EGQVYAWGANSYGQLGTGNKSNQSYPTPV 320



 Score = 80.5 bits (197), Expect = 2e-15
 Identities = 59/200 (29%), Positives = 89/200 (44%), Gaps = 5/200 (2%)
 Frame = +2

Query: 611  EPSKVTGLENSQAVCVLAGSG-HSASLTDAGELYVWGSNKHGQLASQAAFLPLPQKIEAH 787
            EP ++  L   +  C+  GSG H    T  GE++ WG N + QL +      L     + 
Sbjct: 105  EPRRLDSLSGKKIACLSYGSGPHVVLATTEGEVFTWGHNAYSQLGNGTTNHGLVPCHIST 164

Query: 788  RFQNEKVAAVWSGWTHLVAQTETGKVFTWGRADYGQLGRTLESPEGWKPKKQASSLPCSR 967
               N++V  V  G  H +  T  G+VF WG  + GQ+G               S    ++
Sbjct: 165  NLSNKQVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVG---------------SGSTANQ 209

Query: 968  PARSVPSSLP-CLTGAT--EVSCGSEHNLAVVG-GTCYSWGWNEHGMCGDGTEANVWTPK 1135
            P   +P  +  CL   T   ++CG   ++AVV  G  Y WG+N +G  G G+  N  TP 
Sbjct: 210  P---IPRRVTGCLQNKTVVNIACGQMCSMAVVDTGEVYVWGYNGNGQLGLGSGGNQPTPC 266

Query: 1136 PVQALRSSSGLRLGCGAGHS 1195
             + AL+     R+ CG  H+
Sbjct: 267  RIAALQGIRVQRVACGYAHT 286



 Score = 79.7 bits (195), Expect = 3e-15
 Identities = 65/248 (26%), Positives = 99/248 (39%), Gaps = 12/248 (4%)
 Frame = +2

Query: 56  LFAWGANSYGQLGLGHKEDVLLPQQLSEFCKPGCVKRITGGGGHSAIVTDQGSLFVCGLN 235
           +F WG N+Y QLG G     L+P  +S       V  +  G  HS ++T  G +F  G N
Sbjct: 137 VFTWGHNAYSQLGNGTTNHGLVPCHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWGYN 196

Query: 236 KDGQLGLGHTEDVLYFTLCKSLLGC----PIQQVACGWDFTIILTKNGQVLSCGSNSFGQ 403
             GQ+G G T +     + + + GC     +  +ACG   ++ +   G+V   G N  GQ
Sbjct: 197 NSGQVGSGSTANQ---PIPRRVTGCLQNKTVVNIACGQMCSMAVVDTGEVYVWGYNGNGQ 253

Query: 404 LGVPHG-----PRRCVVPQAIEVQREKVVSIXXXXXXXXXXXXSGLVFQWGT---GLASS 559
           LG+  G     P R    Q I VQR     +             G V+ WG    G   +
Sbjct: 254 LGLGSGGNQPTPCRIAALQGIRVQR-----VACGYAHTLVLTDEGQVYAWGANSYGQLGT 308

Query: 560 GRRLCPGQTLPLFLTAKEPSKVTGLENSQAVCVLAGSGHSASLTDAGELYVWGSNKHGQL 739
           G +       P+ +      ++    ++           SA+ T  G +Y+W     GQ 
Sbjct: 309 GNKSNQSYPTPVIVEKDRIIEIAACHSAHT---------SAAKTQGGHVYMW-----GQC 354

Query: 740 ASQAAFLP 763
             Q+  LP
Sbjct: 355 RGQSVTLP 362


>ref|XP_003129374.2| PREDICTED: probable E3 ubiquitin-protein ligase HERC3-like [Sus
            scrofa].
          Length = 989

 Score =  100 bits (249), Expect = 2e-21
 Identities = 81/281 (28%), Positives = 123/281 (43%), Gaps = 4/281 (1%)
 Frame = +2

Query: 314  IQQVACGWDFTIILTKNGQVLSCGSNSFGQLGVPHGPRRCVVPQAIE-VQREKVVSIXXX 490
            I  VACG   ++ L+  GQ+ S G+ S GQLG+        VP+ I+ + ++ ++ +   
Sbjct: 25   IVHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTEESVAVPRLIQKLNQQTILQVSCG 84

Query: 491  XXXXXXXXXSGLVFQWGTGLASSGRRLCPGQTLPLFLTAKEPSKVTGLENSQAVCVLAGS 670
                      G  F WG    +S  +L  G+  P   +   P +V  LE      V AG 
Sbjct: 85   NWHCLALAADGQFFTWG---KNSHGQLGLGKEFP---SQASPQRVRSLEGIPLAQVAAGG 138

Query: 671  GHSASLTDAGELYVWGSNKHGQLA-SQAAFLPLPQKIEAHRFQNEKVAAVWSGWTHLVAQ 847
             HS +L+ +G ++ WG N  GQL  S       P  ++  R Q  KV  +  G  H    
Sbjct: 139  AHSFALSLSGAVFGWGMNNAGQLGLSDEEDRESPCHVKLLRAQ--KVVYISCGEEHTAVL 196

Query: 848  TETGKVFTWGRADYGQLGRTLESPEGWKPKKQASSLPCSRPARSVPSSLPCLTGATEVSC 1027
            T++G VFT+G    GQLG    + E   P++    +                +  T+++C
Sbjct: 197  TKSGGVFTFGAGSCGQLGHDSMNDE-VNPRRVLELMG---------------SEVTQIAC 240

Query: 1028 GSEHNLAVV--GGTCYSWGWNEHGMCGDGTEANVWTPKPVQ 1144
            G +H LA V   G  Y++G    G  G G   NV  P PV+
Sbjct: 241  GRQHTLAFVPSSGLIYAFGCGARGQLGTGHTCNVKCPSPVK 281



 Score = 81.6 bits (200), Expect = 8e-16
 Identities = 53/195 (27%), Positives = 89/195 (45%), Gaps = 3/195 (1%)
 Frame = +2

Query: 620  KVTGLENSQAVCVLAGSGHSASLTDAGELYVWGSNKHGQLA--SQAAFLPLPQKIEAHRF 793
            ++  L +   V V  G  HS +L+D G+L+ WG+   GQL   +    + +P+ I+  + 
Sbjct: 16   QIGALADEHIVHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTEESVAVPRLIQ--KL 73

Query: 794  QNEKVAAVWSGWTHLVAQTETGKVFTWGRADYGQLGRTLESPEGWKPKKQASSLPCSRPA 973
              + +  V  G  H +A    G+ FTWG+  +GQLG   E P    P++        R  
Sbjct: 74   NQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQASPQR-------VRSL 126

Query: 974  RSVPSSLPCLTGATEVSCGSEHNLAV-VGGTCYSWGWNEHGMCGDGTEANVWTPKPVQAL 1150
              +P          +V+ G  H+ A+ + G  + WG N  G  G   E +  +P  V+ L
Sbjct: 127  EGIP--------LAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEEDRESPCHVKLL 178

Query: 1151 RSSSGLRLGCGAGHS 1195
            R+   + + CG  H+
Sbjct: 179  RAQKVVYISCGEEHT 193



 Score = 80.1 bits (196), Expect = 2e-15
 Identities = 67/232 (28%), Positives = 97/232 (41%), Gaps = 2/232 (0%)
 Frame = +2

Query: 56  LFAWGANSYGQLGLGHKEDVLLPQQLSEFCKPGCVKRITGGGGHSAIVTDQGSLFVCGLN 235
           LF+WGA S GQLGL   E+ +   +L +      + +++ G  H   +   G  F  G N
Sbjct: 44  LFSWGAGSDGQLGLMTTEESVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKN 103

Query: 236 KDGQLGLG-HTEDVLYFTLCKSLLGCPIQQVACGWDFTIILTKNGQVLSCGSNSFGQLGV 412
             GQLGLG            +SL G P+ QVA G   +  L+ +G V   G N+ GQLG+
Sbjct: 104 SHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGL 163

Query: 413 PHGPRRCVVPQAIEVQREKVVSIXXXXXXXXXXXXSGLVFQWGTGLASSGRRLCPGQTLP 592
                R        ++ +KVV I            SG VF +G G        C      
Sbjct: 164 SDEEDRESPCHVKLLRAQKVVYISCGEEHTAVLTKSGGVFTFGAG-------SCGQLGHD 216

Query: 593 LFLTAKEPSKVTGLENSQAVCVLAGSGHS-ASLTDAGELYVWGSNKHGQLAS 745
                  P +V  L  S+   +  G  H+ A +  +G +Y +G    GQL +
Sbjct: 217 SMNDEVNPRRVLELMGSEVTQIACGRQHTLAFVPSSGLIYAFGCGARGQLGT 268



 Score = 76.6 bits (187), Expect = 3e-14
 Identities = 71/258 (27%), Positives = 109/258 (42%), Gaps = 10/258 (3%)
 Frame = +2

Query: 158 VKRITGGGGHSAIVTDQGSLFVCGLNKDGQLGLGHTED-VLYFTLCKSLLGCPIQQVACG 334
           +  +  G  HS  ++D+G LF  G   DGQLGL  TE+ V    L + L    I QV+CG
Sbjct: 25  IVHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTEESVAVPRLIQKLNQQTILQVSCG 84

Query: 335 WDFTIILTKNGQVLSCGSNSFGQLGVPHGPRRCVVPQAI-EVQREKVVSIXXXXXXXXXX 511
               + L  +GQ  + G NS GQLG+         PQ +  ++   +  +          
Sbjct: 85  NWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFAL 144

Query: 512 XXSGLVFQWGTGLASSGRRLCPGQTLPLFLTAKE----PSKVTGLENSQAVCVLAGSGHS 679
             SG VF WG   A             L L+ +E    P  V  L   + V +  G  H+
Sbjct: 145 SLSGAVFGWGMNNAGQ-----------LGLSDEEDRESPCHVKLLRAQKVVYISCGEEHT 193

Query: 680 ASLTDAGELYVWGSNKHGQLASQAAFLPLPQKIEAHR---FQNEKVAAVWSGWTHLVA-Q 847
           A LT +G ++ +G+   GQL   +    +  ++   R       +V  +  G  H +A  
Sbjct: 194 AVLTKSGGVFTFGAGSCGQLGHDS----MNDEVNPRRVLELMGSEVTQIACGRQHTLAFV 249

Query: 848 TETGKVFTWGRADYGQLG 901
             +G ++ +G    GQLG
Sbjct: 250 PSSGLIYAFGCGARGQLG 267



 Score = 68.9 bits (167), Expect = 6e-12
 Identities = 59/231 (25%), Positives = 87/231 (37%), Gaps = 6/231 (2%)
 Frame = +2

Query: 521  GLVFQWGTGLASSGRRLCPGQTLPLFLTAKE---PSKVTGLENSQAVCVLAGSGHSASLT 691
            G +F WG G  S G+       L L  T +    P  +  L     + V  G+ H  +L 
Sbjct: 42   GQLFSWGAG--SDGQ-------LGLMTTEESVAVPRLIQKLNQQTILQVSCGNWHCLALA 92

Query: 692  DAGELYVWGSNKHGQLASQAAFLPLPQKIEAHRFQNEKVAAVWSGWTHLVAQTETGKVFT 871
              G+ + WG N HGQL     F            +   +A V +G  H  A + +G VF 
Sbjct: 93   ADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFG 152

Query: 872  WGRADYGQLGRTLESPEGWKPKKQASSLPCSRPARSVPSSLPCLTG--ATEVSCGSEHNL 1045
            WG  + GQLG + E                    R  P  +  L       +SCG EH  
Sbjct: 153  WGMNNAGQLGLSDEED------------------RESPCHVKLLRAQKVVYISCGEEHTA 194

Query: 1046 AVV-GGTCYSWGWNEHGMCGDGTEANVWTPKPVQALRSSSGLRLGCGAGHS 1195
             +   G  +++G    G  G  +  +   P+ V  L  S   ++ CG  H+
Sbjct: 195  VLTKSGGVFTFGAGSCGQLGHDSMNDEVNPRRVLELMGSEVTQIACGRQHT 245



 Score = 66.6 bits (161), Expect = 3e-11
 Identities = 41/123 (33%), Positives = 62/123 (50%), Gaps = 1/123 (0%)
 Frame = +2

Query: 53  ALFAWGANSYGQLGLGHKEDVLLPQQLSEFCKPGCVKRITGGGGHSAIVTDQGSLFVCGL 232
           A+F WG N+ GQLGL  +ED   P  + +  +   V  I+ G  H+A++T  G +F  G 
Sbjct: 149 AVFGWGMNNAGQLGLSDEEDRESPCHV-KLLRAQKVVYISCGEEHTAVLTKSGGVFTFGA 207

Query: 233 NKDGQLGLGHTEDVLYFTLCKSLLGCPIQQVACGWDFTI-ILTKNGQVLSCGSNSFGQLG 409
              GQLG     D +       L+G  + Q+ACG   T+  +  +G + + G  + GQLG
Sbjct: 208 GSCGQLGHDSMNDEVNPRRVLELMGSEVTQIACGRQHTLAFVPSSGLIYAFGCGARGQLG 267

Query: 410 VPH 418
             H
Sbjct: 268 TGH 270



 Score = 55.1 bits (131), Expect = 8e-08
 Identities = 42/149 (28%), Positives = 68/149 (45%), Gaps = 4/149 (2%)
 Frame = +2

Query: 761  PLPQKIEAHRFQNEKVAAVWSGWTHLVAQTETGKVFTWGRADYGQLGRTLESPEGWKPKK 940
            P P   +     +E +  V  G +H +A ++ G++F+WG    GQLG             
Sbjct: 10   PDPTGEQIGALADEHIVHVACGESHSLALSDRGQLFSWGAGSDGQLG------------- 56

Query: 941  QASSLPCSRPARSVPSSLPCLTGAT--EVSCGSEHNLAVVG-GTCYSWGWNEHGMCGDGT 1111
                L  +  + +VP  +  L   T  +VSCG+ H LA+   G  ++WG N HG  G G 
Sbjct: 57   ----LMTTEESVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGK 112

Query: 1112 E-ANVWTPKPVQALRSSSGLRLGCGAGHS 1195
            E  +  +P+ V++L      ++  G  HS
Sbjct: 113  EFPSQASPQRVRSLEGIPLAQVAAGGAHS 141


>ref|XP_001927286.3| PREDICTED: probable E3 ubiquitin-protein ligase HERC1 [Sus scrofa].
          Length = 4807

 Score = 97.4 bits (241), Expect = 1e-20
 Identities = 102/383 (26%), Positives = 155/383 (40%), Gaps = 45/383 (11%)
 Frame = +2

Query: 182  GHSAIVTDQGSLFVCGLNKDGQLGLGHTEDVLYFTLCKSLLGCPIQQVACGWDFTIILTK 361
            G + IV++   ++V G N   QL  G  E +L   L  S      Q +  G   T +++ 
Sbjct: 363  GDAPIVSETCEVYVWGSNSSHQLVEGTQEKILQPKLAPSFSDA--QTIEAGQYCTFVIST 420

Query: 362  NGQVLSCGSNSFGQLGVPHGPRRCVVPQ-AIEVQR--EKVVSIXXXXXXXXXXXXSGLVF 532
            +G V +CG  S+G+LG+     +  + +   E  R  +KV S              G VF
Sbjct: 421  DGSVRACGKGSYGRLGLGDSNNQSTLKKLTFEPHRSIKKVSSSKGSDGHTLAFTTEGEVF 480

Query: 533  QWGTGLASSGRRLCPGQTLPLFLTAKEPSKVTG-LENSQAVCVLAGSGHSASLTDAGELY 709
             WG G      +L  G +     T K P  + G L+    VCV AG  HSA++T+ GELY
Sbjct: 481  SWGDG---DYGKLGHGNS----STQKYPKLIQGPLQGKVVVCVSAGYRHSAAVTEDGELY 533

Query: 710  VWGSNKHGQLA---SQAAFLPLPQKIEAHRFQNEKVAAVWSGWTHLVAQTETGK-VFTWG 877
             WG    G+L    S +  +P   K          V  V  G +H +A ++ G+ V+++G
Sbjct: 534  TWGEGDFGRLGHGDSNSRNIPTLVK------DISNVGEVSCGSSHTIALSKDGRTVWSFG 587

Query: 878  RADYGQLG----------RTLESPEGWKPKKQASSLPCSRPARSV--------PSSLPC- 1000
              D G+LG          + +E+ +G   +K  +    S    S          + L C 
Sbjct: 588  GGDNGKLGHGDTNRVYKPKVIEALQGMFIRKVCAGSQSSLALTSTGQVYAWGCGACLGCG 647

Query: 1001 ----------------LTGATEVSCGSEHNLAVV-GGTCYSWGWNEHGMCGDGTEAN-VW 1126
                             T   ++S G  H LA+      Y+WG N  G CG G     + 
Sbjct: 648  SSEATALRPKLIEELAATRIVDISIGDSHCLALSHDNEVYAWGNNSMGQCGQGNSTGPIT 707

Query: 1127 TPKPVQALRSSSGLRLGCGAGHS 1195
             PK V  L   +  ++  G  HS
Sbjct: 708  KPKKVSGLDGIAIQQISAGTSHS 730



 Score = 93.6 bits (231), Expect = 2e-19
 Identities = 90/335 (26%), Positives = 142/335 (42%), Gaps = 42/335 (12%)
 Frame = +2

Query: 317  QQVACGWDFTIILTKNGQVLSCGSNSFGQLGVPHGPRRCVVPQAIEVQR---EKVVSIXX 487
            QQV CG + T ++  NG VL+CG  S+G+LG  +     V+     +Q     ++V+   
Sbjct: 3976 QQVICGQNCTFVIQANGTVLACGEGSYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCG 4035

Query: 488  XXXXXXXXXXSGLVFQWGTGLASSGRRLCPGQTLPLFLTAKEPSKVTGLENSQAVCVLAG 667
                      SG VF WG G      +L  G +       + P ++  L+  + V +  G
Sbjct: 4036 SDGHSMALTESGEVFSWGDG---DYGKLGHGNS----DRQRRPRQIEALQGEEVVQMSCG 4088

Query: 668  SGHSASLTDAGELYVWGSNKHGQLA-SQAAFLPLPQKIEAHRFQNEKVAAVWSGWTHLVA 844
              HSA +T  G+L+ +G+  +G+L     +   LP+++ A   +  ++  V  G  H +A
Sbjct: 4089 FKHSAVVTSDGKLFTFGNGDYGRLGLGNTSNKKLPERVTA--LEGYQIGQVACGLNHTLA 4146

Query: 845  QTETGK-VFTWGRADYGQLG----RTLESPE------GWKPKKQAS-------------- 949
             +  G  V+ +G  DYG+LG        SP+      G   KK A               
Sbjct: 4147 VSADGSMVWAFGDGDYGKLGLGNSTAKSSPQKVDVLCGIGIKKVACGTQFSVALTKDGHV 4206

Query: 950  ---------SLPCSRPA-RSVPSSLPCLTGAT--EVSCGSEHNLAVVG-GTCYSWGWNEH 1090
                      LP  R    + P  +P L G    +V+ G+EH LA+   G  Y+WG N  
Sbjct: 4207 YTFGQDRLIGLPEGRARNHNRPQQIPVLAGVVIEDVAVGAEHTLALASTGDVYAWGSNSE 4266

Query: 1091 GMCGDGTEANVWTPKPVQALRSSSGLRLGCGAGHS 1195
            G  G G   +V  P  V  L+  +  ++  G  HS
Sbjct: 4267 GQLGLGHTNHVREPTLVTVLQGKNVRQISAGRCHS 4301



 Score = 90.9 bits (224), Expect = 1e-18
 Identities = 76/281 (27%), Positives = 121/281 (43%), Gaps = 6/281 (2%)
 Frame = +2

Query: 56   LFAWGANSYGQLGLGHKEDVLLPQQLSEFCKPGCVKRITGGGGHSAIVTDQGSLFVCGLN 235
            +F+WG   YG+LG G+      P+ +    +   V  ++ G  HSA VT+ G L+  G  
Sbjct: 479  VFSWGDGDYGKLGHGNSSTQKYPKLIQGPLQGKVVVCVSAGYRHSAAVTEDGELYTWGEG 538

Query: 236  KDGQLGLGHTEDVLYFTLCKSLLGCPIQQVACGWDFTIILTKNGQ-VLSCGSNSFGQLGV 412
              G+LG G +      TL K +    + +V+CG   TI L+K+G+ V S G    G+LG 
Sbjct: 539  DFGRLGHGDSNSRNIPTLVKDISN--VGEVSCGSSHTIALSKDGRTVWSFGGGDNGKLG- 595

Query: 413  PHG-PRRCVVPQAIE-VQREKVVSIXXXXXXXXXXXXSGLVFQWGTGLASSGRRLCPGQT 586
             HG   R   P+ IE +Q   +  +            +G V+ WG G        C    
Sbjct: 596  -HGDTNRVYKPKVIEALQGMFIRKVCAGSQSSLALTSTGQVYAWGCGACLG----CGSSE 650

Query: 587  LPLFLTAKEPSKVTGLENSQAVCVLAGSGHSASLTDAGELYVWGSNKHGQLASQAAFLPL 766
                 TA  P  +  L  ++ V +  G  H  +L+   E+Y WG+N  GQ     +  P+
Sbjct: 651  ----ATALRPKLIEELAATRIVDISIGDSHCLALSHDNEVYAWGNNSMGQCGQGNSTGPI 706

Query: 767  PQKIEAHRFQNEKVAAVWSGWTHLVAQT---ETGKVFTWGR 880
             +  +        +  + +G +H +A T      +V  W R
Sbjct: 707  TKPKKVSGLDGIAIQQISAGTSHSLAWTALPRDRQVVAWHR 747



 Score = 82.0 bits (201), Expect = 6e-16
 Identities = 76/297 (25%), Positives = 128/297 (43%), Gaps = 4/297 (1%)
 Frame = +2

Query: 62   AWGANSYGQLGLGHKEDVLLPQQLSEFCKPGCVKRIT---GGGGHSAIVTDQGSLFVCGL 232
            A G  SYG+LGLG   +    ++L+ F     +K+++   G  GH+   T +G +F  G 
Sbjct: 426  ACGKGSYGRLGLGDSNNQSTLKKLT-FEPHRSIKKVSSSKGSDGHTLAFTTEGEVFSWGD 484

Query: 233  NKDGQLGLGHTEDVLYFTLCKS-LLGCPIQQVACGWDFTIILTKNGQVLSCGSNSFGQLG 409
               G+LG G++    Y  L +  L G  +  V+ G+  +  +T++G++ + G   FG+LG
Sbjct: 485  GDYGKLGHGNSSTQKYPKLIQGPLQGKVVVCVSAGYRHSAAVTEDGELYTWGEGDFGRLG 544

Query: 410  VPHGPRRCVVPQAIEVQREKVVSIXXXXXXXXXXXXSGLVFQWGTGLASSGRRLCPGQTL 589
                  R +     ++     VS               +   W  G   +G+ L  G T 
Sbjct: 545  HGDSNSRNIPTLVKDISNVGEVSCGSSHTIALSKDGRTV---WSFGGGDNGK-LGHGDTN 600

Query: 590  PLFLTAKEPSKVTGLENSQAVCVLAGSGHSASLTDAGELYVWGSNKHGQLASQAAFLPLP 769
             ++    +P  +  L+      V AGS  S +LT  G++Y WG        S  A    P
Sbjct: 601  RVY----KPKVIEALQGMFIRKVCAGSQSSLALTSTGQVYAWGCGACLGCGSSEATALRP 656

Query: 770  QKIEAHRFQNEKVAAVWSGWTHLVAQTETGKVFTWGRADYGQLGRTLESPEGWKPKK 940
            + IE       ++  +  G +H +A +   +V+ WG    GQ G+   +    KPKK
Sbjct: 657  KLIE--ELAATRIVDISIGDSHCLALSHDNEVYAWGNNSMGQCGQGNSTGPITKPKK 711



 Score = 81.3 bits (199), Expect = 1e-15
 Identities = 92/384 (23%), Positives = 153/384 (39%), Gaps = 64/384 (16%)
 Frame = +2

Query: 56   LFAWGANSYGQLGLGHKEDVLLPQQLSEFCKPGCVKRITGGGGHSAIVTDQGSLFVCGLN 235
            ++ WGA  +GQL    + +V++P     F +    +++  G   + ++   G++  CG  
Sbjct: 3945 VYLWGAGRHGQLAEAGR-NVMVPAAAPSFSQ---AQQVICGQNCTFVIQANGTVLACGEG 4000

Query: 236  KDGQLGLGHTEDVLYFTLCKSLLGCPIQQV--ACGWD-FTIILTKNGQVLSCGSNSFGQL 406
              G+LG G+++D+   T+  +L G  + Q+  +CG D  ++ LT++G+V S G   +G+L
Sbjct: 4001 SYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSDGHSMALTESGEVFSWGDGDYGKL 4060

Query: 407  GVPHGPRRCVVPQAIEVQREKVVSIXXXXXXXXXXXXSGLVFQWGTGLASSGRRLCPGQT 586
            G  +  R+    Q   +Q E+VV +             G +F +G G      RL  G T
Sbjct: 4061 GHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNG---DYGRLGLGNT 4117

Query: 587  LPLFLTAKEPSKVTGLENSQAVCVLAGSGHSASLT-DAGELYVWGSNKHGQLA-SQAAFL 760
                   K P +VT LE  Q   V  G  H+ +++ D   ++ +G   +G+L    +   
Sbjct: 4118 S----NKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNSTAK 4173

Query: 761  PLPQKIEA--------------------------------------------HRFQNEKV 808
              PQK++                                             +R Q   V
Sbjct: 4174 SSPQKVDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGLPEGRARNHNRPQQIPV 4233

Query: 809  AA------VWSGWTHLVAQTETGKVFTWGRADYGQLG---------RTLESPEGWKPKKQ 943
             A      V  G  H +A   TG V+ WG    GQLG          TL +    K  +Q
Sbjct: 4234 LAGVVIEDVAVGAEHTLALASTGDVYAWGSNSEGQLGLGHTNHVREPTLVTVLQGKNVRQ 4293

Query: 944  ASSLPCSRPARSVPSSLPCLTGAT 1015
             S+  C   A + P   P   G +
Sbjct: 4294 ISAGRCHSAAWTAPPVPPRAPGVS 4317



 Score = 60.8 bits (146), Expect = 1e-09
 Identities = 68/285 (23%), Positives = 113/285 (39%), Gaps = 42/285 (14%)
 Frame = +2

Query: 425  RRCVVPQAIEVQREKVVSIXXXXXXXXXXXXSGLVFQWGTGLASSGRRLCPGQTLPLFLT 604
            R C  P +I+     +VS                V+ WG+   +S  +L  G    +   
Sbjct: 352  RTCASPDSIQTGDAPIVSETCE------------VYVWGS---NSSHQLVEGTQEKILQP 396

Query: 605  AKEPSKVTGLENSQAVCVLAGSGHSASLTDAGELYVWGSNKHGQLA-----SQAAFLPLP 769
               PS       S A  + AG   +  ++  G +   G   +G+L      +Q+    L 
Sbjct: 397  KLAPSF------SDAQTIEAGQYCTFVISTDGSVRACGKGSYGRLGLGDSNNQSTLKKLT 450

Query: 770  QKIEAHRFQNEKVAAVWSGWTHLVAQTETGKVFTWGRADYGQLGR----TLESPEGWKPK 937
               E HR   +KV++      H +A T  G+VF+WG  DYG+LG     T + P+  +  
Sbjct: 451  --FEPHR-SIKKVSSSKGSDGHTLAFTTEGEVFSWGDGDYGKLGHGNSSTQKYPKLIQGP 507

Query: 938  KQASSLPC-------------------------------SRPARSVPSSLPCLTGATEVS 1024
             Q   + C                                  +R++P+ +  ++   EVS
Sbjct: 508  LQGKVVVCVSAGYRHSAAVTEDGELYTWGEGDFGRLGHGDSNSRNIPTLVKDISNVGEVS 567

Query: 1025 CGSEHNLAVV--GGTCYSWGWNEHGMCGDGTEANVWTPKPVQALR 1153
            CGS H +A+   G T +S+G  ++G  G G    V+ PK ++AL+
Sbjct: 568  CGSSHTIALSKDGRTVWSFGGGDNGKLGHGDTNRVYKPKVIEALQ 612


>ref|XP_003361480.1| PREDICTED: probable E3 ubiquitin-protein ligase HERC1-like, partial
            [Sus scrofa].
          Length = 2771

 Score = 93.6 bits (231), Expect = 2e-19
 Identities = 90/335 (26%), Positives = 142/335 (42%), Gaps = 42/335 (12%)
 Frame = +2

Query: 317  QQVACGWDFTIILTKNGQVLSCGSNSFGQLGVPHGPRRCVVPQAIEVQR---EKVVSIXX 487
            QQV CG + T ++  NG VL+CG  S+G+LG  +     V+     +Q     ++V+   
Sbjct: 1940 QQVICGQNCTFVIQANGTVLACGEGSYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCG 1999

Query: 488  XXXXXXXXXXSGLVFQWGTGLASSGRRLCPGQTLPLFLTAKEPSKVTGLENSQAVCVLAG 667
                      SG VF WG G      +L  G +       + P ++  L+  + V +  G
Sbjct: 2000 SDGHSMALTESGEVFSWGDG---DYGKLGHGNS----DRQRRPRQIEALQGEEVVQMSCG 2052

Query: 668  SGHSASLTDAGELYVWGSNKHGQLA-SQAAFLPLPQKIEAHRFQNEKVAAVWSGWTHLVA 844
              HSA +T  G+L+ +G+  +G+L     +   LP+++ A   +  ++  V  G  H +A
Sbjct: 2053 FKHSAVVTSDGKLFTFGNGDYGRLGLGNTSNKKLPERVTA--LEGYQIGQVACGLNHTLA 2110

Query: 845  QTETGK-VFTWGRADYGQLG----RTLESPE------GWKPKKQAS-------------- 949
             +  G  V+ +G  DYG+LG        SP+      G   KK A               
Sbjct: 2111 VSADGSMVWAFGDGDYGKLGLGNSTAKSSPQKVDVLCGIGIKKVACGTQFSVALTKDGHV 2170

Query: 950  ---------SLPCSRPA-RSVPSSLPCLTGAT--EVSCGSEHNLAVVG-GTCYSWGWNEH 1090
                      LP  R    + P  +P L G    +V+ G+EH LA+   G  Y+WG N  
Sbjct: 2171 YTFGQDRLIGLPEGRARNHNRPQQIPVLAGVVIEDVAVGAEHTLALASTGDVYAWGSNSE 2230

Query: 1091 GMCGDGTEANVWTPKPVQALRSSSGLRLGCGAGHS 1195
            G  G G   +V  P  V  L+  +  ++  G  HS
Sbjct: 2231 GQLGLGHTNHVREPTLVTVLQGKNVRQISAGRCHS 2265



 Score = 81.3 bits (199), Expect = 1e-15
 Identities = 92/384 (23%), Positives = 153/384 (39%), Gaps = 64/384 (16%)
 Frame = +2

Query: 56   LFAWGANSYGQLGLGHKEDVLLPQQLSEFCKPGCVKRITGGGGHSAIVTDQGSLFVCGLN 235
            ++ WGA  +GQL    + +V++P     F +    +++  G   + ++   G++  CG  
Sbjct: 1909 VYLWGAGRHGQLAEAGR-NVMVPAAAPSFSQ---AQQVICGQNCTFVIQANGTVLACGEG 1964

Query: 236  KDGQLGLGHTEDVLYFTLCKSLLGCPIQQV--ACGWD-FTIILTKNGQVLSCGSNSFGQL 406
              G+LG G+++D+   T+  +L G  + Q+  +CG D  ++ LT++G+V S G   +G+L
Sbjct: 1965 SYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSDGHSMALTESGEVFSWGDGDYGKL 2024

Query: 407  GVPHGPRRCVVPQAIEVQREKVVSIXXXXXXXXXXXXSGLVFQWGTGLASSGRRLCPGQT 586
            G  +  R+    Q   +Q E+VV +             G +F +G G      RL  G T
Sbjct: 2025 GHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNG---DYGRLGLGNT 2081

Query: 587  LPLFLTAKEPSKVTGLENSQAVCVLAGSGHSASLT-DAGELYVWGSNKHGQLA-SQAAFL 760
                   K P +VT LE  Q   V  G  H+ +++ D   ++ +G   +G+L    +   
Sbjct: 2082 S----NKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNSTAK 2137

Query: 761  PLPQKIEA--------------------------------------------HRFQNEKV 808
              PQK++                                             +R Q   V
Sbjct: 2138 SSPQKVDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGLPEGRARNHNRPQQIPV 2197

Query: 809  AA------VWSGWTHLVAQTETGKVFTWGRADYGQLG---------RTLESPEGWKPKKQ 943
             A      V  G  H +A   TG V+ WG    GQLG          TL +    K  +Q
Sbjct: 2198 LAGVVIEDVAVGAEHTLALASTGDVYAWGSNSEGQLGLGHTNHVREPTLVTVLQGKNVRQ 2257

Query: 944  ASSLPCSRPARSVPSSLPCLTGAT 1015
             S+  C   A + P   P   G +
Sbjct: 2258 ISAGRCHSAAWTAPPVPPRAPGVS 2281


>ref|XP_003359267.1| PREDICTED: probable E3 ubiquitin-protein ligase HERC4-like [Sus
           scrofa].
          Length = 331

 Score = 87.0 bits (214), Expect = 2e-17
 Identities = 73/234 (31%), Positives = 108/234 (46%), Gaps = 6/234 (2%)
 Frame = +2

Query: 56  LFAWGANSYGQLGLGH-KEDVLLPQQLSEFCKPGCVKRITGGGGHSAIVTDQGSLFVCGL 232
           +  WG  S+GQLGLG   E+++L  + S+F     V+ +  G  H+  V D G+++ CG 
Sbjct: 1   MLCWGNASFGQLGLGGIDEEIVLEPRKSDFFINKKVRDVGCGLRHTVFVLDDGTVYTCGC 60

Query: 233 NKDGQLGLGHTEDVLYFTLCKSLLGCPIQQVACGWDFTIILTKNGQVLSCGSNSFGQLGV 412
           N  GQ  LGH +         +L    I  V+CG   T+ L   GQV + G +S GQLG+
Sbjct: 61  NDLGQ--LGHEKSRKKPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGL 118

Query: 413 PHGPRRCV-VPQAIEVQRE-KVVSIXXXXXXXXXXXXSGLVFQWGTGLASSGRRLCPGQT 586
             G   C+ VP+ I+   + ++V +            +  VF WG               
Sbjct: 119 -LGTEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQ--------- 168

Query: 587 LPLFLTAKE---PSKVTGLENSQAVCVLAGSGHSASLTDAGELYVWGSNKHGQL 739
           L L +  K+   P  +  L     + V AG  HS  LT +G ++ WG NK GQL
Sbjct: 169 LGLGIDCKKQSSPQLIKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQL 222



 Score = 77.8 bits (190), Expect = 1e-14
 Identities = 55/194 (28%), Positives = 92/194 (47%), Gaps = 6/194 (3%)
 Frame = +2

Query: 608  KEPSKVTGLENSQAVCVLAGSGHSASLTDAGELYVWGSNKHGQLA--SQAAFLPLPQKIE 781
            K+P +V  L+    V V  G  H+ +L D G++Y WG +  GQL        + +P+ I+
Sbjct: 73   KKPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGLLGTEECIRVPRNIK 132

Query: 782  AHRFQNEKVAAVWSGWTHLVAQTETGKVFTWGRADYGQLGRTLESPEGWKPKKQASSLPC 961
            +    + ++  V  G+ H +A ++  +VF WG+  YGQLG  ++       KKQ+S    
Sbjct: 133  S--LSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGIDC------KKQSS---- 180

Query: 962  SRPARSVPSSLPCLTGA--TEVSCGSEHNLAV-VGGTCYSWGWNEHGMCGDGTE-ANVWT 1129
                   P  +  L G    +V+ G  H+  + + G  + WG N+ G  G   E  ++ T
Sbjct: 181  -------PQLIKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDSLNT 233

Query: 1130 PKPVQALRSSSGLR 1171
              P + L+ S  LR
Sbjct: 234  LNPARPLKKSDFLR 247



 Score = 73.2 bits (178), Expect = 3e-13
 Identities = 47/121 (38%), Positives = 66/121 (54%), Gaps = 2/121 (1%)
 Frame = +2

Query: 56  LFAWGANSYGQLGL-GHKEDVLLPQQLSEFCKPGCVKRITGGGGHSAIVTDQGSLFVCGL 232
           ++AWG +S GQLGL G +E + +P+ +        V+ +  G  HS  ++    +F  G 
Sbjct: 105 VYAWGLDSDGQLGLLGTEECIRVPRNIKSLSDIQIVQ-VACGYYHSLALSKASEVFCWGQ 163

Query: 233 NKDGQLGLG-HTEDVLYFTLCKSLLGCPIQQVACGWDFTIILTKNGQVLSCGSNSFGQLG 409
           NK GQLGLG   +      L KSLLG P  QVA G   + +LT +G +   G N FGQLG
Sbjct: 164 NKYGQLGLGIDCKKQSSPQLIKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLG 223

Query: 410 V 412
           +
Sbjct: 224 L 224



 Score = 55.1 bits (131), Expect = 8e-08
 Identities = 49/168 (29%), Positives = 69/168 (41%), Gaps = 7/168 (4%)
 Frame = +2

Query: 713  WGSNKHGQLAS---QAAFLPLPQKIEAHRFQNEKVAAVWSGWTHLVAQTETGKVFTWGRA 883
            WG+   GQL         +  P+K +   F N+KV  V  G  H V   + G V+T G  
Sbjct: 4    WGNASFGQLGLGGIDEEIVLEPRKSDF--FINKKVRDVGCGLRHTVFVLDDGTVYTCGCN 61

Query: 884  DYGQLGRTLESPEGWKPKKQASSLPCSRPARSVPSSLPCL--TGATEVSCGSEHNLAVVG 1057
            D GQLG                       +R  P  +  L       VSCG  H LA+  
Sbjct: 62   DLGQLGH--------------------EKSRKKPEQVVALDAQNIVAVSCGEAHTLALND 101

Query: 1058 -GTCYSWGWNEHGMCG-DGTEANVWTPKPVQALRSSSGLRLGCGAGHS 1195
             G  Y+WG +  G  G  GTE  +  P+ +++L     +++ CG  HS
Sbjct: 102  KGQVYAWGLDSDGQLGLLGTEECIRVPRNIKSLSDIQIVQVACGYYHS 149



 Score = 53.1 bits (126), Expect = 3e-07
 Identities = 30/74 (40%), Positives = 38/74 (51%)
 Frame = +2

Query: 56  LFAWGANSYGQLGLGHKEDVLLPQQLSEFCKPGCVKRITGGGGHSAIVTDQGSLFVCGLN 235
           +F WG N YGQLGLG         QL +        ++  GG HS ++T  G++F  G N
Sbjct: 158 VFCWGQNKYGQLGLGIDCKKQSSPQLIKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRN 217

Query: 236 KDGQLGLGHTEDVL 277
           K GQLGL    D L
Sbjct: 218 KFGQLGLNDENDSL 231


  Database: RefSeq49_SP.fasta
    Posted date:  Oct 17, 2011  1:42 PM
  Number of letters in database: 11,343,932
  Number of sequences in database:  24,897
  
Lambda     K      H
   0.318    0.134    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 24897
Number of Hits to DB: 36,856,361
Number of extensions: 1182414
Number of successful extensions: 5036
Number of sequences better than 1.0e-05: 21
Number of HSP's gapped: 4738
Number of HSP's successfully gapped: 82
Length of query: 421
Length of database: 11,343,932
Length adjustment: 102
Effective length of query: 319
Effective length of database: 8,804,438
Effective search space: 2808615722
Effective search space used: 2808615722
Neighboring words threshold: 12
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 34 (17.7 bits)

BLASTN 2.2.24 [Aug-08-2010]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= 20110601C-004015
         (1263 letters)

Database: Sscrofa_10.2.fasta 
           4582 sequences; 2,808,509,378 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

Sscrofa_Chr02                                                         375   e-101

>Sscrofa_Chr02 
||          Length = 162569375

 Score =  375 bits (189), Expect = e-101
 Identities = 195/197 (98%)
 Strand = Plus / Plus

                                                                            
Query: 1055     ggtgggacgtgttactcttggggctggaacgagcacggcatgtgtggggatggcaccgaa 1114
                ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 44416803 ggtgggacgtgttactcttggggctggaacgagcacggcatgtgtggggatggcaccgaa 44416862

                                                                            
Query: 1115     gccaacgtctggaccccgaagcccgtgcaggctctgcggtcatcatcgggactccggctg 1174
                ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 44416863 gccaacgtctggaccccgaagcccgtgcaggctctgcggtcatcatcgggactccggctg 44416922

                                                                            
Query: 1175     ggctgtggggctgggcactccctggccctctgccagctgccacccctccctgccctgggg 1234
                |||||||||||||| |||||||||||||||||||||||||||||||||||||||||||| 
Sbjct: 44416923 ggctgtggggctggccactccctggccctctgccagctgccacccctccctgccctgggc 44416982

                                 
Query: 1235     cagcgccccagggtccc 1251
                |||||||||||||||||
Sbjct: 44416983 cagcgccccagggtccc 44416999



 Score =  339 bits (171), Expect = 2e-90
 Identities = 171/171 (100%)
 Strand = Plus / Plus

                                                                            
Query: 850      agaaactggcaaggtgtttacctggggccgagcggactatggtcagctggggaggacgtt 909
                ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 44234017 agaaactggcaaggtgtttacctggggccgagcggactatggtcagctggggaggacgtt 44234076

                                                                            
Query: 910      ggagtctcctgaaggctggaaaccgaagaagcaagcttcatccttgccctgctccaggcc 969
                ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 44234077 ggagtctcctgaaggctggaaaccgaagaagcaagcttcatccttgccctgctccaggcc 44234136

                                                                   
Query: 970      agcgaggagtgtgccttcgtccctgccttgcttaacgggagcgactgaggt 1020
                |||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 44234137 agcgaggagtgtgccttcgtccctgccttgcttaacgggagcgactgaggt 44234187



 Score =  319 bits (161), Expect = 2e-84
 Identities = 161/161 (100%)
 Strand = Plus / Plus

                                                                            
Query: 691      agatgcaggagagctgtatgtttggggaagcaacaaacacgggcaactggcttcccaggc 750
                ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 44205990 agatgcaggagagctgtatgtttggggaagcaacaaacacgggcaactggcttcccaggc 44206049

                                                                            
Query: 751      tgctttccttcctctaccccagaaaatagaagcacatcgttttcagaatgaaaaggtggc 810
                ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 44206050 tgctttccttcctctaccccagaaaatagaagcacatcgttttcagaatgaaaaggtggc 44206109

                                                         
Query: 811      tgccgtctggagtgggtggacgcacctggttgctcagacag 851
                |||||||||||||||||||||||||||||||||||||||||
Sbjct: 44206110 tgccgtctggagtgggtggacgcacctggttgctcagacag 44206150



 Score =  315 bits (159), Expect = 3e-83
 Identities = 159/159 (100%)
 Strand = Plus / Plus

                                                                            
Query: 201      cagatcaaggaagcctttttgtttgtggcctgaacaaagatgggcaactggggcttggtc 260
                ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 44184317 cagatcaaggaagcctttttgtttgtggcctgaacaaagatgggcaactggggcttggtc 44184376

                                                                            
Query: 261      acaccgaggatgtcctttatttcaccctctgcaaatccctccttggctgtcccatccaac 320
                ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 44184377 acaccgaggatgtcctttatttcaccctctgcaaatccctccttggctgtcccatccaac 44184436

                                                       
Query: 321      aggtggcctgtggctgggattttaccattatacttacaa 359
                |||||||||||||||||||||||||||||||||||||||
Sbjct: 44184437 aggtggcctgtggctgggattttaccattatacttacaa 44184475



 Score =  272 bits (137), Expect = 4e-70
 Identities = 137/137 (100%)
 Strand = Plus / Plus

                                                                            
Query: 67       gggtgcaaatagctatgggcaacttggccttggccacaaggaagatgtgcttttgcccca 126
                ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 44182480 gggtgcaaatagctatgggcaacttggccttggccacaaggaagatgtgcttttgcccca 44182539

                                                                            
Query: 127      gcaactgagtgaattctgtaaacctggatgtgtcaagaggatcacgggaggagggggcca 186
                ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 44182540 gcaactgagtgaattctgtaaacctggatgtgtcaagaggatcacgggaggagggggcca 44182599

                                 
Query: 187      ctctgctattgtcacag 203
                |||||||||||||||||
Sbjct: 44182600 ctctgctattgtcacag 44182616



 Score =  232 bits (117), Expect = 4e-58
 Identities = 117/117 (100%)
 Strand = Plus / Plus

                                                                            
Query: 514      agctagtggcctcgtgttccagtggggaactggtttggcatcatctggacggcggttgtg 573
                ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 44198039 agctagtggcctcgtgttccagtggggaactggtttggcatcatctggacggcggttgtg 44198098

                                                                         
Query: 574      ccctgggcagacgctcccactgtttttgacagcaaaggaaccgagcaaagtgacagg 630
                |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 44198099 ccctgggcagacgctcccactgtttttgacagcaaaggaaccgagcaaagtgacagg 44198155



 Score =  192 bits (97), Expect = 3e-46
 Identities = 97/97 (100%)
 Strand = Plus / Plus

                                                                            
Query: 360      aaaatggtcaagttctgtcatgtgggtccaactcctttggccagttaggagttcctcatg 419
                ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 44186469 aaaatggtcaagttctgtcatgtgggtccaactcctttggccagttaggagttcctcatg 44186528

                                                     
Query: 420      ggcctcgaagatgtgtggtcccccaggccattgaggt 456
                |||||||||||||||||||||||||||||||||||||
Sbjct: 44186529 ggcctcgaagatgtgtggtcccccaggccattgaggt 44186565



 Score =  135 bits (68), Expect = 7e-29
 Identities = 68/68 (100%)
 Strand = Plus / Plus

                                                                            
Query: 1        ttcccgcatggagcgcgagccgagcgcctcggaggccgccccacctgcgaccgcgctctt 60
                ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 44178056 ttcccgcatggagcgcgagccgagcgcctcggaggccgccccacctgcgaccgcgctctt 44178115

                        
Query: 61       cgcctggg 68
                ||||||||
Sbjct: 44178116 cgcctggg 44178123



 Score =  129 bits (65), Expect = 4e-27
 Identities = 65/65 (100%)
 Strand = Plus / Plus

                                                                            
Query: 628      aggcctagagaattctcaagcagtatgtgttcttgctggctcaggtcactctgcttccct 687
                ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 44201196 aggcctagagaattctcaagcagtatgtgttcttgctggctcaggtcactctgcttccct 44201255

                     
Query: 688      gacag 692
                |||||
Sbjct: 44201256 gacag 44201260



 Score =  125 bits (63), Expect = 6e-26
 Identities = 63/63 (100%)
 Strand = Plus / Plus

                                                                            
Query: 453      aggtccagagagagaaggttgttagtattgctgctggactgaggcatgcgttagctgcaa 512
                ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 44192900 aggtccagagagagaaggttgttagtattgctgctggactgaggcatgcgttagctgcaa 44192959

                   
Query: 513      cag 515
                |||
Sbjct: 44192960 cag 44192962



 Score = 81.8 bits (41), Expect = 8e-13
 Identities = 41/41 (100%)
 Strand = Plus / Plus

                                                         
Query: 1017     aggtctcttgtggctcagagcataacctggcagtggttggt 1057
                |||||||||||||||||||||||||||||||||||||||||
Sbjct: 44319622 aggtctcttgtggctcagagcataacctggcagtggttggt 44319662


  Database: Sscrofa_10.2.fasta
    Posted date:  Nov 16, 2011 10:34 AM
  Number of letters in database: 2,808,509,378
  Number of sequences in database:  4582
  
Lambda     K      H
    1.37    0.711     1.31 

Gapped
Lambda     K      H
    1.37    0.711     1.31 


Matrix: blastn matrix:1 -3
Gap Penalties: Existence: 5, Extension: 2
Number of Sequences: 4582
Number of Hits to DB: 38,506,330
Number of extensions: 276
Number of successful extensions: 276
Number of sequences better than 1.0e-05: 1
Number of HSP's gapped: 276
Number of HSP's successfully gapped: 11
Length of query: 1263
Length of database: 2,808,509,378
Length adjustment: 21
Effective length of query: 1242
Effective length of database: 2,808,413,156
Effective search space: 3488049139752
Effective search space used: 3488049139752
X1: 11 (21.8 bits)
X2: 15 (29.7 bits)
X3: 50 (99.1 bits)
S1: 18 (36.2 bits)
S2: 30 (60.0 bits)