Animal-Genome cDNA 20110601C-007518

BLASTX 2.2.24 [Aug-08-2010]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= 20110601C-007518
         (3088 letters)

Database: RefSeq49_BP.fasta 
           33,088 sequences; 17,681,374 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

Alignment   gi|NP_001193443.1| filamin-A [Bos taurus].                          1766   0.0  
Alignment   gi|NP_001178389.1| filamin-B [Bos taurus].                          1313   0.0  
Alignment   gi|XP_002697040.1| PREDICTED: filamin B, beta isoform 4 [Bos ta...  1313   0.0  
Alignment   gi|XP_002697037.1| PREDICTED: filamin B, beta isoform 1 [Bos ta...  1313   0.0  
Alignment   gi|XP_877592.3| PREDICTED: filamin B, beta isoform 7 [Bos tauru...  1313   0.0  
Alignment   gi|XP_002697039.1| PREDICTED: filamin B, beta isoform 3 [Bos ta...  1308   0.0  
Alignment   gi|XP_002697038.1| PREDICTED: filamin B, beta isoform 2 [Bos ta...  1308   0.0  
Alignment   gi|XP_002702811.1| PREDICTED: filamin B, beta [Bos taurus].         1308   0.0  
Alignment   gi|XP_002702810.1| PREDICTED: filamin B, beta [Bos taurus].         1308   0.0  
Alignment   gi|NP_001193919.1| filamin-C [Bos taurus].                           798   0.0  

>ref|NP_001193443.1| filamin-A [Bos taurus].
          Length = 2647

 Score = 1766 bits (4573), Expect = 0.0
 Identities = 870/913 (95%), Positives = 882/913 (96%)
 Frame = +3

Query: 3    PFQVTALAGEQPSVXXXXXXXXXXXXYTYAQGGQQTWAPERPLVGVNGLDVTSLRPFDLV 182
            PFQVTALAG+QP+             YTYAQGGQQTWAPERPLVGVNGLDV+SLRPFDLV
Sbjct: 1735 PFQVTALAGDQPTAQPSLRPQQLAPPYTYAQGGQQTWAPERPLVGVNGLDVSSLRPFDLV 1794

Query: 183  IPFTIKKGEITGEVRMPSGKVAQPAITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGS 362
            IPFTIKKGE+TGEVRMPSGKVAQPAITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGS
Sbjct: 1795 IPFTIKKGEVTGEVRMPSGKVAQPAITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGS 1854

Query: 363  PLQFYVDYVNCGHVTAYGPGLSHGVVNKPAVFTVNTKDAGEGGLSLAIEGPSKAEISCTD 542
            PLQFYVDYVNCGHVTAYGPGL+HGVVNKPA+FTVNTKDAGEGGLSLAIEGPSKAEISCTD
Sbjct: 1855 PLQFYVDYVNCGHVTAYGPGLTHGVVNKPAIFTVNTKDAGEGGLSLAIEGPSKAEISCTD 1914

Query: 543  NQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARVTGDDSMRMSHLKVGSAADIPIN 722
            NQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARVTGDDSMRMSHLKVGSAADIPIN
Sbjct: 1915 NQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARVTGDDSMRMSHLKVGSAADIPIN 1974

Query: 723  ISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNGQHVASSP 902
            ISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNGQHVASSP
Sbjct: 1975 ISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNGQHVASSP 2034

Query: 903  IPVVISQSEIGDASRVRVSGRGLHEGHTFEPAEFIIDTRDAGYGGLSLSIEGPSKVDINT 1082
            IPVVISQSEIGDASRVRVSG+GLHEGHTFEPAEFIIDTRDAGYGGLSLSIEGPSKVDINT
Sbjct: 2035 IPVVISQSEIGDASRVRVSGQGLHEGHTFEPAEFIIDTRDAGYGGLSLSIEGPSKVDINT 2094

Query: 1083 EDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTGEGRVKESITRRQRAPSVA 1262
            EDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTGEGRVKESITRR+RAPSVA
Sbjct: 2095 EDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTGEGRVKESITRRRRAPSVA 2154

Query: 1263 NVGSHCDLSLKIPEISIQDMTAQVTSPSGKSHEAEIVEGENHTYCIRFVPAEMGMHTVSV 1442
            NVGSHCDLSLKIPEISIQDMTAQVTSPSGKSHEAEIVEGENHTYCIRFVPAEMGMHTVSV
Sbjct: 2155 NVGSHCDLSLKIPEISIQDMTAQVTSPSGKSHEAEIVEGENHTYCIRFVPAEMGMHTVSV 2214

Query: 1443 KYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLERAEAGVPAEFSIWTREAGAGGLAIA 1622
            KYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLERAEAGVPAEFSIWTREAGAGGLAIA
Sbjct: 2215 KYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLERAEAGVPAEFSIWTREAGAGGLAIA 2274

Query: 1623 VEGPSKAEISFEDRKDGSCGVAYVVQEPGDYEVSVKFNEEHIPDSPFVVPVASPSGDARR 1802
            VEGPSKAEISFEDRKDGSCGVAYVVQEPGDYEVSVKFNEEHIPDSPFVVPVASPSGDARR
Sbjct: 2275 VEGPSKAEISFEDRKDGSCGVAYVVQEPGDYEVSVKFNEEHIPDSPFVVPVASPSGDARR 2334

Query: 1803 LTVSSLQESGLKVNQPASFAVSLNGAKGAIDAKVHSPSGALEECYVTEIDQDKYAVRFIP 1982
            LTVSSLQESGLKVNQPASFAVSLNGAKGAIDAKVHSPSGALEECYVTEIDQDKYAVRFIP
Sbjct: 2335 LTVSSLQESGLKVNQPASFAVSLNGAKGAIDAKVHSPSGALEECYVTEIDQDKYAVRFIP 2394

Query: 1983 RENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPGLVSAYGAGLEGGVTGSPAEFIVNT 2162
            RENG+YLIDVKFNGTHIPGSPFKIRVGEPGHGGDPGLVSAYGAGLEGG+TGSPAEFIVNT
Sbjct: 2395 RENGIYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPGLVSAYGAGLEGGITGSPAEFIVNT 2454

Query: 2163 SNAGAGALSVTIDGPSKVKMDCQECPEGYRVTYTPMAPGSYLISIKYGGPYHIGGSPFKA 2342
            SNAGAGALSVTIDGPSKVKMDCQECPEGYRVTYTPMAPGSYLISIKYGGPYHI GSPFKA
Sbjct: 2455 SNAGAGALSVTIDGPSKVKMDCQECPEGYRVTYTPMAPGSYLISIKYGGPYHIAGSPFKA 2514

Query: 2343 RVTGHRLVSNHSLHETSSVFVDSLTKTXXXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQ 2522
            RVTGHRLVSNHSLHETSSVFVDSLTKT                SKVLAKG+GLSKAY+GQ
Sbjct: 2515 RVTGHRLVSNHSLHETSSVFVDSLTKTATIPQHSAPGPGPTDASKVLAKGVGLSKAYMGQ 2574

Query: 2523 KGSFTVDCSKAGNNMLLVGVHGPRTPCEEILVKHVGSRLYSVSYLLKDKGEYTLVVKWGD 2702
            K SFTVDCSKAGNNMLLVGVHGPRTPCEEILVKHVGSRLYSVSYLLKDKGEYTLVVKWGD
Sbjct: 2575 KSSFTVDCSKAGNNMLLVGVHGPRTPCEEILVKHVGSRLYSVSYLLKDKGEYTLVVKWGD 2634

Query: 2703 EHIPGSPYRVLVP 2741
            EHIPGSPYRVLVP
Sbjct: 2635 EHIPGSPYRVLVP 2647



 Score =  426 bits (1095), Expect = e-119
 Identities = 282/883 (31%), Positives = 436/883 (49%), Gaps = 52/883 (5%)
 Frame = +3

Query: 246  AQPAITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFYV-DYVNCGHVTAYGPG 422
            A+ +  DNKDG+ +V Y P EAG + +++ Y    +PGSP +  V D  +   V   GPG
Sbjct: 1398 AKMSCMDNKDGSCSVEYVPYEAGTYSLNVTYGGHQVPGSPFKVPVHDVTDASKVKCSGPG 1457

Query: 423  LSHGVV--NKPAVFTVNTKDAGEGGLSLAIEGPSKA--EISCTDNQDGTCSVSYLPVLPG 590
            LS G+V  N P  F V+T  AG   L + ++GP      +   DN DGT +V+Y+P   G
Sbjct: 1458 LSPGMVRANLPQSFQVDTSKAGMAPLQVKVQGPKGLVEPVDVVDNADGTQTVNYVPSREG 1517

Query: 591  DYSILVKYNEQHIPGSPFTARV--TGDDS--------MRMSHLKVGSAADIPINISETDL 740
             YSI V Y ++ +P SPF  +V  T D S        +  + +      +  I+  +   
Sbjct: 1518 PYSISVLYGDEEVPRSPFKVKVLPTHDASKVKASGPGLNTTGVPASLPVEFTIDAKDAGE 1577

Query: 741  SLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNGQHVASSPIPVVIS 920
             LL   +  P G+ +   ++   +G   +++VP  TG + + +K  G  +  SP  V   
Sbjct: 1578 GLLAVQITDPEGKPKKTHIQDNHDGTYTVAYVPDVTGRYTILIKYGGDEIPFSPYRVRAV 1637

Query: 921  QSEIGDASR----VRVSGRGLHEG-----HTFEPAEFIIDTRDAGYGGLSLSIEGP--SK 1067
             +  GDAS+    V + G GL  G        E     +DT+ AG G ++ ++  P  S+
Sbjct: 1638 PT--GDASKCTVTVSIGGHGLGAGIGPTIQIGEETVITVDTKAAGKGKVTCTVCTPDGSE 1695

Query: 1068 VDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTG--EGRVKESITRR 1241
            VD++  + EDGT  + Y   +PG Y+I ++F  +HVP SPF V      +   + S+  +
Sbjct: 1696 VDVDVVENEDGTFDIFYTAPQPGKYVICVRFGGEHVPNSPFQVTALAGDQPTAQPSLRPQ 1755

Query: 1242 QRAPSVA---------------------NVGSHCDLSLKIP-EISIQDMTAQVTSPSGKS 1355
            Q AP                        +V S     L IP  I   ++T +V  PSGK 
Sbjct: 1756 QLAPPYTYAQGGQQTWAPERPLVGVNGLDVSSLRPFDLVIPFTIKKGEVTGEVRMPSGKV 1815

Query: 1356 HEAEIVEGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGG 1535
             +  I + ++ T  +R+ P+E G+H + ++Y   H+PGSP QF V  +  G    V A G
Sbjct: 1816 AQPAITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFYVDYVNCG---HVTAYG 1872

Query: 1536 PGLERAEAGVPAEFSIWTREAGAGGLAIAVEGPSKAEISFEDRKDGSCGVAYVVQEPGDY 1715
            PGL       PA F++ T++AG GGL++A+EGPSKAEIS  D +DG+C V+Y+   PGDY
Sbjct: 1873 PGLTHGVVNKPAIFTVNTKDAGEGGLSLAIEGPSKAEISCTDNQDGTCSVSYLPVLPGDY 1932

Query: 1716 EVSVKFNEEHIPDSPFVVPVASPSGDARRLTVSSLQESGLKVNQPASFAVSLNGAK-GAI 1892
             + VK+NE+HIP SPF   V   +GD       S++ S LKV   A   ++++      +
Sbjct: 1933 SILVKYNEQHIPGSPFTARV---TGD------DSMRMSHLKVGSAADIPINISETDLSLL 1983

Query: 1893 DAKVHSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPG 2072
             A V  PSG  E C +  +      + F+P+E G +L+ VK NG H+  SP  + + +  
Sbjct: 1984 TATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNGQHVASSPIPVVISQ-S 2042

Query: 2073 HGGDPGLVSAYGAGLEGGVTGSPAEFIVNTSNAGAGALSVTIDGPSKVKMDCQECPEG-Y 2249
              GD   V   G GL  G T  PAEFI++T +AG G LS++I+GPSKV ++ ++  +G  
Sbjct: 2043 EIGDASRVRVSGQGLHEGHTFEPAEFIIDTRDAGYGGLSLSIEGPSKVDINTEDLEDGTC 2102

Query: 2250 RVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSVFVDSLTKTXX 2429
            RVTY P  PG+Y+I+IK+    H+ GSPF  +VTG   V             +S+T+   
Sbjct: 2103 RVTYCPTEPGNYIINIKF-ADQHVPGSPFSVKVTGEGRVK------------ESITR--- 2146

Query: 2430 XXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKAGNNMLLVGVHGPRTPCEE 2609
                               +    S A VG     ++   +     +   V  P     E
Sbjct: 2147 -------------------RRRAPSVANVGSHCDLSLKIPEISIQDMTAQVTSPSGKSHE 2187

Query: 2610 ILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLV 2738
              +    +  Y + ++  + G +T+ VK+  +H+PGSP++  V
Sbjct: 2188 AEIVEGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTV 2230



 Score =  350 bits (897), Expect = 6e-96
 Identities = 267/889 (30%), Positives = 412/889 (46%), Gaps = 44/889 (4%)
 Frame = +3

Query: 204  GEITGEVRMPSGK--VAQPAITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFY 377
            GE+   ++ P+G+    +P +    D T    Y PS  G+H + + +  + IP SP    
Sbjct: 414  GEVEVVIQDPAGQKGTVEPQLEARGDSTYRCSYQPSVEGVHMVHVTFAGVPIPRSPYTVT 473

Query: 378  VDYV-NCGHVTAYGPGLS-HGV-VNKPAVFTVNTKDAGEGGLSLAIEGPSKAE-ISCTDN 545
            V    N G   A G GL   GV V + A F V TK AG G L + ++GP   E +   D 
Sbjct: 474  VGQACNPGACRAVGRGLQPKGVRVKETADFKVYTKGAGSGELKVTVKGPKGEERVKQKDL 533

Query: 546  QDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARV---TGDDSMR-----MSHLKVGS 701
             DG     Y P++PG Y++ + +  Q+I  SPF  +V    G+  +R     +    VG 
Sbjct: 534  GDGVYGFEYYPMIPGTYTVTITWGGQNIGRSPFEVKVGTECGNQKVRAWGPGLEGGVVGK 593

Query: 702  AADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNG 881
            +AD  +     D+  L  +V  PS  +  C  K   +G   + + P+E GE+ VHV  N 
Sbjct: 594  SADFVVEAIGDDVGTLGFSVEGPSQAKIECDDKG--DGSCDVRYWPQEAGEYAVHVLCNS 651

Query: 882  QHVASSPIPVVISQSEIGDA------SRVRVSGRGLHEGHTF--EPAEFIIDTRDAGYGG 1037
            + +  SP       ++I DA       RV+  G GL +      + AEF +D +  G   
Sbjct: 652  EDIRLSPF-----MADIRDAPQDFHPDRVKARGPGLEKTGVAVNKSAEFTVDAKHGGKAP 706

Query: 1038 LSLSIEGPS--KVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTGE 1211
            L + ++      V+   +D  +GT   +Y P +P  +   + +    +P SPF V V G 
Sbjct: 707  LKVQVQDNEGCPVEATVKDNGNGTYSCSYVPRKPVKHTAMVSWGGVSIPNSPFRVNV-GA 765

Query: 1212 GRVKESITRRQRAPSVANVG--SHCDLSLKIP-------EISIQDMTAQ-VTSPSGKSHE 1361
            G     +  +   P VA  G  +H      +        ++SI    A  V  P+    +
Sbjct: 766  GSHPNKV--KVYGPGVAKTGLKAHEPTYFTVDCTEAGQGDVSIGIKCAPGVVGPAEADID 823

Query: 1362 AEIVEGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPG 1541
             +I+  +N T+ +++ P   G +T+ V +  Q  P SP +  V P  +  A KV+A GPG
Sbjct: 824  FDIIRNDNDTFTVKYTPRGAGSYTIMVLFADQATPTSPIRVKVEPSHD--ASKVKAEGPG 881

Query: 1542 LERA--EAGVPAEFSIWTREAGAGGLAIAVEGPSKAE----ISFEDRKDGSCGVAYVVQE 1703
            L R   E   P  F++ T+ AG G L +   GP+K +    +   D  D +  V Y   +
Sbjct: 882  LSRTGVELSKPTHFTVNTKAAGKGKLDVQFSGPAKGDAVRDVDIIDHHDNTYTVKYTPVQ 941

Query: 1704 PGDYEVSVKFNEEHIPDSPFVVPVASPSGDARRLTVSSLQESGLKVNQPASFAVSLNGA- 1880
             G   ++V +  + IP SPF V V SPS D  ++ VS L E  + V +   F V   GA 
Sbjct: 942  QGPVGINVTYGGDAIPKSPFSVGV-SPSLDLSKIKVSGLGEK-VDVGKDQEFTVKSKGAG 999

Query: 1881 -KGAIDAKVHSPSGALEECYVTE-IDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKI 2054
             +G + +K+  PSGA   C V   +  D   VRF+PRE G Y ++V ++G  +PGSPF +
Sbjct: 1000 GQGKVLSKIVGPSGAAVPCKVEPGLGADNSVVRFVPREEGPYEVEVTYDGVPVPGSPFSL 1059

Query: 2055 RVGEPGHGGDPGLVSAYGAGLEGGVTGSPAEFIVNTSNAGAGALSVTIDGPSKVKMDCQE 2234
                P     P  V A+G GL+GG  GSPA F ++T  AG G L +T++GP + +++C +
Sbjct: 1060 EAVPPTK---PSKVKAFGPGLQGGSAGSPARFTIDTKGAGTGGLGLTVEGPCEAQLECLD 1116

Query: 2235 CPEGY-RVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSVFVDS 2411
              +G   V+Y P  PG Y I+I +    HI GSPFKA V                     
Sbjct: 1117 NGDGTCSVSYVPTEPGDYNINILFADT-HIPGSPFKAHVV-------------------- 1155

Query: 2412 LTKTXXXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKAGNNMLLVGVHGP 2591
                                SKV   G GL +A  G+ G F VDCS AG+  L + +   
Sbjct: 1156 ---------------PCFDPSKVKCSGPGLERATAGEAGQFHVDCSSAGSAELTIEIRSE 1200

Query: 2592 RTPCEEILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLV 2738
                 E+ ++  G   ++++Y+    G YT+ +K+G + +P  P ++ V
Sbjct: 1201 AGLPAEVHIQDHGDGTHTITYIPLCPGAYTVTIKYGGQPVPNFPSKLQV 1249



 Score =  319 bits (817), Expect = 1e-86
 Identities = 231/760 (30%), Positives = 360/760 (47%), Gaps = 43/760 (5%)
 Frame = +3

Query: 189  FTIK------KGEITGEVRMPSG-----KVAQPAITDNKDGTVTVRYAPSEAGLHEMDIR 335
            FT+K      +G++  ++  PSG     KV      DN      VR+ P E G +E+++ 
Sbjct: 991  FTVKSKGAGGQGKVLSKIVGPSGAAVPCKVEPGLGADNS----VVRFVPREEGPYEVEVT 1046

Query: 336  YDNMHIPGSPLQFY-VDYVNCGHVTAYGPGLSHGVVNKPAVFTVNTKDAGEGGLSLAIEG 512
            YD + +PGSP     V       V A+GPGL  G    PA FT++TK AG GGL L +EG
Sbjct: 1047 YDGVPVPGSPFSLEAVPPTKPSKVKAFGPGLQGGSAGSPARFTIDTKGAGTGGLGLTVEG 1106

Query: 513  PSKAEISCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARVTG--DDSM---- 674
            P +A++ C DN DGTCSVSY+P  PGDY+I + + + HIPGSPF A V    D S     
Sbjct: 1107 PCEAQLECLDNGDGTCSVSYVPTEPGDYNINILFADTHIPGSPFKAHVVPCFDPSKVKCS 1166

Query: 675  --RMSHLKVGSAADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKET 848
               +     G A    ++ S    + LT  +   +G      ++   +G   I+++P   
Sbjct: 1167 GPGLERATAGEAGQFHVDCSSAGSAELTIEIRSEAGLPAEVHIQDHGDGTHTITYIPLCP 1226

Query: 849  GEHLVHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEGHTFEPA--EFIIDTR- 1019
            G + V +K  GQ V + P  + +  +   D S ++  G G+     F  A  EF +D R 
Sbjct: 1227 GAYTVTIKYGGQPVPNFPSKLQVEPAV--DTSGIQCYGPGIEGQGVFREATTEFSVDARA 1284

Query: 1020 --DAGYGGLSLSIEGPS--KVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSP 1187
                G   +   +  PS    +   +D  DGT +V Y P E G + +++ +    VP SP
Sbjct: 1285 LTQTGGPHVKARVANPSGNLTETYVQDCGDGTYKVEYTPYEEGLHSVDVTYDGSPVPSSP 1344

Query: 1188 FSVKVTGEGRVKESITRRQRAPSVANVGSHCDLSLKIPEISIQDMTAQVTSPSGKSHEAE 1367
            F V VT EG     +                  +++        +   V  PS    +  
Sbjct: 1345 FQVPVT-EGCDPSRVRVHGPGIQSGTTNKPNKFTVETRGAGTGGLGLAVEGPS--EAKMS 1401

Query: 1368 IVEGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLE 1547
             ++ ++ +  + +VP E G ++++V Y G  VPGSPF+  V  + +  A KV+  GPGL 
Sbjct: 1402 CMDNKDGSCSVEYVPYEAGTYSLNVTYGGHQVPGSPFKVPVHDVTD--ASKVKCSGPGLS 1459

Query: 1548 --RAEAGVPAEFSIWTREAGAGGLAIAVEGPS--KAEISFEDRKDGSCGVAYVVQEPGDY 1715
                 A +P  F + T +AG   L + V+GP      +   D  DG+  V YV    G Y
Sbjct: 1460 PGMVRANLPQSFQVDTSKAGMAPLQVKVQGPKGLVEPVDVVDNADGTQTVNYVPSREGPY 1519

Query: 1716 EVSVKFNEEHIPDSPFVVPVASPSGDARRLTVS--SLQESGLKVNQPASFAVSLNGA-KG 1886
             +SV + +E +P SPF V V  P+ DA ++  S   L  +G+  + P  F +    A +G
Sbjct: 1520 SISVLYGDEEVPRSPFKVKVL-PTHDASKVKASGPGLNTTGVPASLPVEFTIDAKDAGEG 1578

Query: 1887 AIDAKVHSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGE 2066
             +  ++  P G  ++ ++ +     Y V ++P   G Y I +K+ G  IP SP+++R   
Sbjct: 1579 LLAVQITDPEGKPKKTHIQDNHDGTYTVAYVPDVTGRYTILIKYGGDEIPFSPYRVRAVP 1638

Query: 2067 PGHGGDPGL-VSAYGAGLEGGV-----TGSPAEFIVNTSNAGAGALSVTIDGP--SKVKM 2222
             G      + VS  G GL  G+      G      V+T  AG G ++ T+  P  S+V +
Sbjct: 1639 TGDASKCTVTVSIGGHGLGAGIGPTIQIGEETVITVDTKAAGKGKVTCTVCTPDGSEVDV 1698

Query: 2223 DCQECPEG-YRVTYTPMAPGSYLISIKYGGPYHIGGSPFK 2339
            D  E  +G + + YT   PG Y+I +++GG  H+  SPF+
Sbjct: 1699 DVVENEDGTFDIFYTAPQPGKYVICVRFGGE-HVPNSPFQ 1737



 Score =  289 bits (740), Expect = 9e-78
 Identities = 249/893 (27%), Positives = 387/893 (43%), Gaps = 47/893 (5%)
 Frame = +3

Query: 201  KGEITGEVRMPSGKVAQPAITDNKDG--TVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQF 374
            +GE+   V  P+G   +  +T N D   T +V Y P   G H++ + +   HI  SP + 
Sbjct: 313  QGEVLVYVEDPAGHQEEAKVTANNDKNRTFSVWYVPEVTGTHKVTVLFAGQHIAKSPFEV 372

Query: 375  YVD--YVNCGHVTAYGPGL--SHGVVNKPAVFTVNTKDAGEGGLSLAIEGPS----KAEI 530
            YVD    +   VTA GPGL  S  + NK   F + T  AG G + + I+ P+      E 
Sbjct: 373  YVDKSQGDASKVTAQGPGLEPSGNIANKTTYFEIFTAGAGMGEVEVVIQDPAGQKGTVEP 432

Query: 531  SCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARV----------TGDDSMRM 680
                  D T   SY P + G + + V +    IP SP+T  V               ++ 
Sbjct: 433  QLEARGDSTYRCSYQPSVEGVHMVHVTFAGVPIPRSPYTVTVGQACNPGACRAVGRGLQP 492

Query: 681  SHLKVGSAADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHL 860
              ++V   AD  +         L  TV  P G EE    K L +G  G  + P   G + 
Sbjct: 493  KGVRVKETADFKVYTKGAGSGELKVTVKGPKG-EERVKQKDLGDGVYGFEYYPMIPGTYT 551

Query: 861  VHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEGHTFEPAEFIIDTRDAGYGGL 1040
            V +   GQ++  SP  V +  +E G+  +VR  G GL  G   + A+F+++      G L
Sbjct: 552  VTITWGGQNIGRSPFEVKVG-TECGN-QKVRAWGPGLEGGVVGKSADFVVEAIGDDVGTL 609

Query: 1041 SLSIEGPSKVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTGEGRV 1220
              S+EGPS+  I  +D  DG+C V Y P E G Y +++    + +  SPF   +    + 
Sbjct: 610  GFSVEGPSQAKIECDDKGDGSCDVRYWPQEAGEYAVHVLCNSEDIRLSPFMADIRDAPQD 669

Query: 1221 KESITRRQRAPSVANVG----SHCDLSLKIPEISIQDMTAQVTSPSGKSHEAEIVEGENH 1388
                  + R P +   G       + ++         +  QV    G   EA + +  N 
Sbjct: 670  FHPDRVKARGPGLEKTGVAVNKSAEFTVDAKHGGKAPLKVQVQDNEGCPVEATVKDNGNG 729

Query: 1389 TYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAH--KVRAGGPGLERA--E 1556
            TY   +VP +   HT  V + G  +P SPF+  VG     G+H  KV+  GPG+ +   +
Sbjct: 730  TYSCSYVPRKPVKHTAMVSWGGVSIPNSPFRVNVG----AGSHPNKVKVYGPGVAKTGLK 785

Query: 1557 AGVPAEFSIWTREAGAGGLAIAVE------GPSKAEISFE--DRKDGSCGVAYVVQEPGD 1712
            A  P  F++   EAG G ++I ++      GP++A+I F+     + +  V Y  +  G 
Sbjct: 786  AHEPTYFTVDCTEAGQGDVSIGIKCAPGVVGPAEADIDFDIIRNDNDTFTVKYTPRGAGS 845

Query: 1713 YEVSVKFNEEHIPDSPFVVPVASPSGDARRLTVS--SLQESGLKVNQPASFAVSLNGA-K 1883
            Y + V F ++  P SP  V V  PS DA ++      L  +G+++++P  F V+   A K
Sbjct: 846  YTIMVLFADQATPTSPIRVKV-EPSHDASKVKAEGPGLSRTGVELSKPTHFTVNTKAAGK 904

Query: 1884 GAIDAKVHSPS--GALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIR 2057
            G +D +   P+   A+ +  + +   + Y V++ P + G   I+V + G  IP SPF + 
Sbjct: 905  GKLDVQFSGPAKGDAVRDVDIIDHHDNTYTVKYTPVQQGPVGINVTYGGDAIPKSPFSVG 964

Query: 2058 VGEPGHGGDPGLVSAYGAGLEGGVTGSPAEFIVNTSNAGA-GALSVTIDGPSKVKMDCQE 2234
            V       D   +   G G +  V G   EF V +  AG  G +   I GPS   + C+ 
Sbjct: 965  VSP---SLDLSKIKVSGLGEKVDV-GKDQEFTVKSKGAGGQGKVLSKIVGPSGAAVPCKV 1020

Query: 2235 CP----EGYRVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSVF 2402
             P    +   V + P   G Y + + Y G   + GSPF                      
Sbjct: 1021 EPGLGADNSVVRFVPREEGPYEVEVTYDG-VPVPGSPFS--------------------- 1058

Query: 2403 VDSLTKTXXXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKAGNNMLLVGV 2582
            ++++  T                SKV A G GL     G    FT+D   AG   L + V
Sbjct: 1059 LEAVPPT--------------KPSKVKAFGPGLQGGSAGSPARFTIDTKGAGTGGLGLTV 1104

Query: 2583 HGPRTPCE-EILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLV 2738
             G   PCE ++     G    SVSY+  + G+Y + + + D HIPGSP++  V
Sbjct: 1105 EG---PCEAQLECLDNGDGTCSVSYVPTEPGDYNINILFADTHIPGSPFKAHV 1154



 Score =  232 bits (591), Expect = 2e-60
 Identities = 233/841 (27%), Positives = 368/841 (43%), Gaps = 50/841 (5%)
 Frame = +3

Query: 354  PGSPLQFYVDYVNCGHVTAYGPGL--SHGVVNKPAVFTVNTKDAGEGGLSLAIEGPS--- 518
            PG+PL+     +N     AYGPG+  +  +V K A FTV T+ AG+G + + +E P+   
Sbjct: 271  PGAPLR---PKLNPKKARAYGPGIEPTGNMVKKRAEFTVETRSAGQGEVLVYVEDPAGHQ 327

Query: 519  -KAEISCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARV--TGDDSMRMSHL 689
             +A+++  ++++ T SV Y+P + G + + V +  QHI  SPF   V  +  D+ +++  
Sbjct: 328  EEAKVTANNDKNRTFSVWYVPEVTGTHKVTVLFAGQHIAKSPFEVYVDKSQGDASKVTAQ 387

Query: 690  KVGSAADIPINISETDLSLLTA---------TVVPPSGRE---EPCLLKRLRNGHVGISF 833
              G      I    T   + TA          +  P+G++   EP L  R  +     S+
Sbjct: 388  GPGLEPSGNIANKTTYFEIFTAGAGMGEVEVVIQDPAGQKGTVEPQLEAR-GDSTYRCSY 446

Query: 834  VPKETGEHLVHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEG--HTFEPAEFI 1007
             P   G H+VHV   G  +  SP  V + Q+   +    R  GRGL        E A+F 
Sbjct: 447  QPSVEGVHMVHVTFAGVPIPRSPYTVTVGQA--CNPGACRAVGRGLQPKGVRVKETADFK 504

Query: 1008 IDTRDAGYGGLSLSIEGPSKVD-INTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGS 1184
            + T+ AG G L ++++GP   + +  +DL DG     Y P  PG Y + I +  Q++  S
Sbjct: 505  VYTKGAGSGELKVTVKGPKGEERVKQKDLGDGVYGFEYYPMIPGTYTVTITWGGQNIGRS 564

Query: 1185 PFSVKVTGE-GRVKESITRRQRAPSVAN--VGSHCDLSLKIPEISIQDMTAQVTSPSGKS 1355
            PF VKV  E G  K     R   P +    VG   D  ++     +  +   V  PS   
Sbjct: 565  PFEVKVGTECGNQKV----RAWGPGLEGGVVGKSADFVVEAIGDDVGTLGFSVEGPSQAK 620

Query: 1356 HEAEIVEGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEG-GAHKVRAG 1532
             E +  +  + +  +R+ P E G + V V    + +  SPF   +    +     +V+A 
Sbjct: 621  IECD--DKGDGSCDVRYWPQEAGEYAVHVLCNSEDIRLSPFMADIRDAPQDFHPDRVKAR 678

Query: 1533 GPGLERAEAGV--PAEFSIWTREAGAGGLAIAVEGPS--KAEISFEDRKDGSCGVAYVVQ 1700
            GPGLE+    V   AEF++  +  G   L + V+       E + +D  +G+   +YV +
Sbjct: 679  GPGLEKTGVAVNKSAEFTVDAKHGGKAPLKVQVQDNEGCPVEATVKDNGNGTYSCSYVPR 738

Query: 1701 EPGDYEVSVKFNEEHIPDSPFVVPVASPSGDAR-RLTVSSLQESGLKVNQPASFAVSLNG 1877
            +P  +   V +    IP+SPF V V + S   + ++    + ++GLK ++P  F V    
Sbjct: 739  KPVKHTAMVSWGGVSIPNSPFRVNVGAGSHPNKVKVYGPGVAKTGLKAHEPTYFTVDCTE 798

Query: 1878 A-KGAIDAKVH------SPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIP 2036
            A +G +   +        P+ A  +  +   D D + V++ PR  G Y I V F     P
Sbjct: 799  AGQGDVSIGIKCAPGVVGPAEADIDFDIIRNDNDTFTVKYTPRGAGSYTIMVLFADQATP 858

Query: 2037 GSPFKIRVGEPGHGGDPGLVSAYGAGLE--GGVTGSPAEFIVNTSNAGAGALSVTIDGPS 2210
             SP +++V EP H  D   V A G GL   G     P  F VNT  AG G L V   GP+
Sbjct: 859  TSPIRVKV-EPSH--DASKVKAEGPGLSRTGVELSKPTHFTVNTKAAGKGKLDVQFSGPA 915

Query: 2211 K----VKMDCQECPEG-YRVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNH 2375
            K      +D  +  +  Y V YTP+  G   I++ YGG   I  SPF   V+        
Sbjct: 916  KGDAVRDVDIIDHHDNTYTVKYTPVQQGPVGINVTYGGD-AIPKSPFSVGVS-------- 966

Query: 2376 SLHETSSVFVDSLTKTXXXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKA 2555
                                            SK+   GLG  K  VG+   FTV    A
Sbjct: 967  ---------------------------PSLDLSKIKVSGLG-EKVDVGKDQEFTVKSKGA 998

Query: 2556 GNN----MLLVGVHGPRTPCEEILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSP 2723
            G        +VG  G   PC+  +   +G+    V ++ +++G Y + V +    +PGSP
Sbjct: 999  GGQGKVLSKIVGPSGAAVPCK--VEPGLGADNSVVRFVPREEGPYEVEVTYDGVPVPGSP 1056

Query: 2724 Y 2726
            +
Sbjct: 1057 F 1057


>ref|NP_001178389.1| filamin-B [Bos taurus].
          Length = 2633

 Score = 1313 bits (3398), Expect = 0.0
 Identities = 626/881 (71%), Positives = 744/881 (84%)
 Frame = +3

Query: 99   GQQTWAPERPLVGVNGLDVTSLRPFDLVIPFTIKKGEITGEVRMPSGKVAQPAITDNKDG 278
            G + W  E   V V+ ++    +PFDLVIPF ++KGEITGEV MPSGK A+P I DNKDG
Sbjct: 1754 GFRPWVTEEAYVPVSNMNGLGFKPFDLVIPFAVRKGEITGEVHMPSGKTAKPEIVDNKDG 1813

Query: 279  TVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFYVDYVNCGHVTAYGPGLSHGVVNKPAVF 458
            TVTVRYAP+E GLHEM I+Y   HIP SPLQFYV+Y N G V+AYGPGL +GV NK A F
Sbjct: 1814 TVTVRYAPTEVGLHEMHIKYMGSHIPESPLQFYVNYPNSGSVSAYGPGLVYGVANKTATF 1873

Query: 459  TVNTKDAGEGGLSLAIEGPSKAEISCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGS 638
            T+ T+DAGEGGL LAIEGPSKAEISC DN+DGTC+V+YLP LPGDYSILVKYN++HIPGS
Sbjct: 1874 TIVTEDAGEGGLDLAIEGPSKAEISCIDNKDGTCTVTYLPTLPGDYSILVKYNDKHIPGS 1933

Query: 639  PFTARVTGDDSMRMSHLKVGSAADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGH 818
            PFTA++T DDS R S +K+GSAAD  ++ISETDLS LTA++  PSGR+EPCLLKRL N H
Sbjct: 1934 PFTAKIT-DDSRRCSQVKLGSAADFLLDISETDLSTLTASIKAPSGRDEPCLLKRLPNNH 1992

Query: 819  VGISFVPKETGEHLVHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEGHTFEPA 998
            +GISF+P+E GEHLV +KKNG HVA+SP+ +++ QSEIGDA R +V GRGL EG TFE +
Sbjct: 1993 IGISFIPREVGEHLVSIKKNGNHVANSPVSIMVVQSEIGDARRAKVYGRGLSEGRTFEMS 2052

Query: 999  EFIIDTRDAGYGGLSLSIEGPSKVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVP 1178
            +FI+DTRDAGYGG+SL++EGPSKVDI TEDLEDGTC+V+Y PT PG YI++ KFAD+HVP
Sbjct: 2053 DFIVDTRDAGYGGISLAVEGPSKVDIQTEDLEDGTCKVSYFPTVPGVYIVSTKFADEHVP 2112

Query: 1179 GSPFSVKVTGEGRVKESITRRQRAPSVANVGSHCDLSLKIPEISIQDMTAQVTSPSGKSH 1358
            GSPF+VK++GEGRVKESITR  RAPSVA VGS CDL+LKIPEI   DM+A VTSPSG+  
Sbjct: 2113 GSPFTVKISGEGRVKESITRTSRAPSVATVGSICDLNLKIPEIDSSDMSAHVTSPSGRVT 2172

Query: 1359 EAEIVEGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGP 1538
            EAEIV    +++C+RFVP EMG+HTVSVKY+GQHV GSPFQFTVGPLGEGGAHKVRAGGP
Sbjct: 2173 EAEIVPVGKNSHCVRFVPQEMGVHTVSVKYRGQHVTGSPFQFTVGPLGEGGAHKVRAGGP 2232

Query: 1539 GLERAEAGVPAEFSIWTREAGAGGLAIAVEGPSKAEISFEDRKDGSCGVAYVVQEPGDYE 1718
            GLER EAGVPAEFSIWTREAGAGGL+IAVEGPSKAEI+F+D K+GSCGV+Y+ QEPG+YE
Sbjct: 2233 GLERGEAGVPAEFSIWTREAGAGGLSIAVEGPSKAEITFDDHKNGSCGVSYIAQEPGNYE 2292

Query: 1719 VSVKFNEEHIPDSPFVVPVASPSGDARRLTVSSLQESGLKVNQPASFAVSLNGAKGAIDA 1898
            VS+KFN+EHIP+SP+VVPV +PS DARRLTV SLQESGLKVNQPASFA+ LNGAKG IDA
Sbjct: 2293 VSIKFNDEHIPESPYVVPVIAPSDDARRLTVLSLQESGLKVNQPASFAIRLNGAKGKIDA 2352

Query: 1899 KVHSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGHG 2078
            KVHSPSGA+EEC+V+E++ DKYAVRFIP ENG++ IDVKFNG+H+ GSPFK+RVGEPG  
Sbjct: 2353 KVHSPSGAVEECHVSELEPDKYAVRFIPHENGIHTIDVKFNGSHVVGSPFKVRVGEPGQA 2412

Query: 2079 GDPGLVSAYGAGLEGGVTGSPAEFIVNTSNAGAGALSVTIDGPSKVKMDCQECPEGYRVT 2258
            G+P LVSAYGAGLEGG TG  +EF +NT+ AG G LSVTI+GPSKVKMDCQE PEGY+V 
Sbjct: 2413 GNPALVSAYGAGLEGGSTGIQSEFFINTTRAGPGTLSVTIEGPSKVKMDCQETPEGYKVM 2472

Query: 2259 YTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSVFVDSLTKTXXXXX 2438
            YTPMAPG+YLI +KYGGP HI GSPFKA+VTG RLVS  S +ETSS+ V+S+T++     
Sbjct: 2473 YTPMAPGNYLIGVKYGGPNHIVGSPFKAKVTGQRLVSPGSANETSSILVESVTRSSTETC 2532

Query: 2439 XXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKAGNNMLLVGVHGPRTPCEEILV 2618
                       SKV +KG GLSKA++GQK SF VDCSKAG+NMLL+GVHGP TPCEE+ +
Sbjct: 2533 YSAIPKASSDASKVTSKGAGLSKAFLGQKSSFLVDCSKAGSNMLLIGVHGPTTPCEEVSM 2592

Query: 2619 KHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLVP 2741
            KHVG++ Y+V+Y++K++G+Y L VKWG+EHIPGSP+ V VP
Sbjct: 2593 KHVGNQQYNVTYVVKERGDYVLAVKWGEEHIPGSPFHVTVP 2633



 Score =  429 bits (1102), Expect = e-119
 Identities = 287/893 (32%), Positives = 423/893 (47%), Gaps = 36/893 (4%)
 Frame = +3

Query: 168  PFDLVIPFTIK-----KGEITGEVRMPSGKVAQPAITDNKDGTVTVRYAPSEAGLHEMDI 332
            P  L + F I      +G +  ++    GK  +  + DNKDGT  V Y P + G + + +
Sbjct: 1564 PASLPVEFAIDARDAGEGLLAVQITDQEGKPKRAIVHDNKDGTYAVTYIPDKTGRYMIGV 1623

Query: 333  RYDNMHIPGSPLQFYVDYV-NCGHVTAYGPGLSHGVVNKPAV-FTVNTKDAGEGGLSLAI 506
             Y    IP SP +       +     A GPG++  V     V F V+ K AG+G ++  +
Sbjct: 1624 TYGGDDIPLSPYRIRATQTGDASKCLATGPGIASTVKTGEEVGFVVDAKTAGKGKVTCTV 1683

Query: 507  EGP--SKAEISCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARVTGDDSMRM 680
              P  ++AE    +N+DGT  + Y    PG Y I V++    IP SPFT   T  +   +
Sbjct: 1684 LTPDGTEAEADVIENEDGTYDIFYTAAKPGTYVIYVRFGGVDIPNSPFTVMATDGEVAAV 1743

Query: 681  SHLKVGSA-----------ADIPIN------ISETDLSL--------LTATVVPPSGREE 785
              + V +            A +P++          DL +        +T  V  PSG+  
Sbjct: 1744 KEVPVNACPPGFRPWVTEEAYVPVSNMNGLGFKPFDLVIPFAVRKGEITGEVHMPSGKTA 1803

Query: 786  PCLLKRLRNGHVGISFVPKETGEHLVHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGR 965
               +   ++G V + + P E G H +H+K  G H+  SP+   ++    G  S     G 
Sbjct: 1804 KPEIVDNKDGTVTVRYAPTEVGLHEMHIKYMGSHIPESPLQFYVNYPNSGSVS---AYGP 1860

Query: 966  GLHEGHTFEPAEFIIDTRDAGYGGLSLSIEGPSKVDINTEDLEDGTCRVTYCPTEPGNYI 1145
            GL  G   + A F I T DAG GGL L+IEGPSK +I+  D +DGTC VTY PT PG+Y 
Sbjct: 1861 GLVYGVANKTATFTIVTEDAGEGGLDLAIEGPSKAEISCIDNKDGTCTVTYLPTLPGDYS 1920

Query: 1146 INIKFADQHVPGSPFSVKVTGEGRVKESITRRQRAPSVANVGSHCDLSLKIPEISIQDMT 1325
            I +K+ D+H+PGSPF+ K+T +           R  S   +GS  D  L I E  +  +T
Sbjct: 1921 ILVKYNDKHIPGSPFTAKITDD----------SRRCSQVKLGSAADFLLDISETDLSTLT 1970

Query: 1326 AQVTSPSGKSHEAEIVEGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGE 1505
            A + +PSG+     +    N+   I F+P E+G H VS+K  G HV  SP    V     
Sbjct: 1971 ASIKAPSGRDEPCLLKRLPNNHIGISFIPREVGEHLVSIKKNGNHVANSPVSIMVVQSEI 2030

Query: 1506 GGAHKVRAGGPGLERAEAGVPAEFSIWTREAGAGGLAIAVEGPSKAEISFEDRKDGSCGV 1685
            G A + +  G GL        ++F + TR+AG GG+++AVEGPSK +I  ED +DG+C V
Sbjct: 2031 GDARRAKVYGRGLSEGRTFEMSDFIVDTRDAGYGGISLAVEGPSKVDIQTEDLEDGTCKV 2090

Query: 1686 AYVVQEPGDYEVSVKFNEEHIPDSPFVVPVASPSGDARRLTVSSLQESGLKVNQPASFAV 1865
            +Y    PG Y VS KF +EH+P SPF V ++        +T +S   S   V       +
Sbjct: 2091 SYFPTVPGVYIVSTKFADEHVPGSPFTVKISGEGRVKESITRTSRAPSVATVGSICDLNL 2150

Query: 1866 SLNGAKGA-IDAKVHSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGS 2042
             +     + + A V SPSG + E  +  + ++ + VRF+P+E GV+ + VK+ G H+ GS
Sbjct: 2151 KIPEIDSSDMSAHVTSPSGRVTEAEIVPVGKNSHCVRFVPQEMGVHTVSVKYRGQHVTGS 2210

Query: 2043 PFKIRVGEPGHGGDPGLVSAYGAGLEGGVTGSPAEFIVNTSNAGAGALSVTIDGPSKVKM 2222
            PF+  VG  G GG    V A G GLE G  G PAEF + T  AGAG LS+ ++GPSK ++
Sbjct: 2211 PFQFTVGPLGEGG-AHKVRAGGPGLERGEAGVPAEFSIWTREAGAGGLSIAVEGPSKAEI 2269

Query: 2223 DCQECPEG-YRVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSV 2399
               +   G   V+Y    PG+Y +SIK+    HI  SP+   V                 
Sbjct: 2270 TFDDHKNGSCGVSYIAQEPGNYEVSIKFNDE-HIPESPYVVPVIA--------------- 2313

Query: 2400 FVDSLTKTXXXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKAGNNMLLVG 2579
                                     ++    L  S   V Q  SF +  + A    +   
Sbjct: 2314 -------------------PSDDARRLTVLSLQESGLKVNQPASFAIRLNGA-KGKIDAK 2353

Query: 2580 VHGPRTPCEEILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLV 2738
            VH P    EE  V  +    Y+V ++  + G +T+ VK+   H+ GSP++V V
Sbjct: 2354 VHSPSGAVEECHVSELEPDKYAVRFIPHENGIHTIDVKFNGSHVVGSPFKVRV 2406



 Score =  320 bits (820), Expect = 5e-87
 Identities = 242/787 (30%), Positives = 368/787 (46%), Gaps = 70/787 (8%)
 Frame = +3

Query: 201  KGEITGEVRMPSGKVAQPAITD--NKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQF 374
            +G++   +  PS KV    +     ++G+ T ++ P E GL+ +D+ YD   +PGSP   
Sbjct: 974  QGKLDVTILSPSRKVVPCLVAPMAGREGS-TAKFIPREEGLYAIDLTYDGHPVPGSPYVV 1032

Query: 375  YVDYV-NCGHVTAYGPGLSHGVVNKPAVFTVNTKDAGEGGLSLAIEGPSKAEISCTDNQD 551
                  +   V A+GPGL  G+V KPA FT++TK AG GGL L +EGP +A+I C+DN D
Sbjct: 1033 EASLPPDPTKVKAHGPGLRGGLVGKPAEFTIDTKGAGTGGLGLTVEGPCEAKIECSDNGD 1092

Query: 552  GTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARV--------TGDDSMRMSHLKVGSAA 707
            GTCSVSYLP  PG+Y + + + E HIPGSPF A +               + H KVG   
Sbjct: 1093 GTCSVSYLPTKPGEYFVNILFEEVHIPGSPFKADIEMPFDPSKVVASGPGLEHGKVGEPG 1152

Query: 708  DIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNGQH 887
             + ++ SE     L    V  SG +    ++  ++G   +++VP   G + + +K  G+ 
Sbjct: 1153 LLSVDCSEAGPGTLGLEAVSDSGAKAEVCIENNKDGTYAVTYVPLTAGMYTLTMKYGGEL 1212

Query: 888  VASSPIPVVISQSEIGDASRVRVSGRGLHEGHTFEPA--EFIIDTR---DAGYGGLSLSI 1052
            V   P  V +  +   D SRV+V G G+     F  A  +F +D+R     G   +   I
Sbjct: 1213 VPHFPTRVKVEPAV--DTSRVKVFGPGIEGKDVFREATTDFTVDSRPLTQVGGDHIKAHI 1270

Query: 1053 EGPS--KVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVT------- 1205
              PS    +    D  DGT +V Y P E G +++ + + D  VP SPF V VT       
Sbjct: 1271 ANPSGASTECFVTDNADGTYQVEYTPFEKGLHVVEVTYDDVPVPNSPFKVAVTEGCQPSR 1330

Query: 1206 ----GEGRVKESITRRQRAPSVANVGSHCDLSLKIPEISIQDMTAQVTSPSGKSHEAEIV 1373
                G G +KE+ T +    +V   G+            I  +   V  PS    +    
Sbjct: 1331 VQAQGPG-LKEAFTNKPNVFTVVTRGA-----------GIGGLGITVEGPS--ESKINCR 1376

Query: 1374 EGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGL-ER 1550
            + ++ +    +VP   G + V++ Y G H+PGSPF+  V  + +    KV+  GPGL   
Sbjct: 1377 DNKDGSCSAEYVPFAPGDYDVNITYGGAHIPGSPFRVPVKDVVD--PSKVKIVGPGLGSG 1434

Query: 1551 AEAGVPAEFSIWTREAGAGGLAIAVEGPSKAE---------------------------- 1646
              A V   F++ + +AG   L + V GP   +                            
Sbjct: 1435 VRARVLQSFTVDSSKAGLAPLEVRVMGPRADQTISWSRRSPLKAISGFFKRDRKGDFMET 1494

Query: 1647 -----ISFEDRKDGSCGVAYVVQEPGDYEVSVKFNEEHIPDSPFVVPVASPSGDARRLTV 1811
                 ++  D  DG+  V Y   + G Y VSVK+ +E IP SPF V V  P+ DA ++T 
Sbjct: 1495 GLVEPVNVVDNGDGTHTVTYTPSQEGPYMVSVKYADEEIPRSPFKVKVL-PTYDASKVTA 1553

Query: 1812 S--SLQESGLKVNQPASFAVSLNGA-KGAIDAKVHSPSGALEECYVTEIDQDKYAVRFIP 1982
            S   L   G+  + P  FA+    A +G +  ++    G  +   V +     YAV +IP
Sbjct: 1554 SGPGLSTYGVPASLPVEFAIDARDAGEGLLAVQITDQEGKPKRAIVHDNKDGTYAVTYIP 1613

Query: 1983 RENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPGLVSAYGAGLEGGV-TGSPAEFIVN 2159
             + G Y+I V + G  IP SP++IR  +    GD     A G G+   V TG    F+V+
Sbjct: 1614 DKTGRYMIGVTYGGDDIPLSPYRIRATQT---GDASKCLATGPGIASTVKTGEEVGFVVD 1670

Query: 2160 TSNAGAGALSVTIDGP--SKVKMDCQECPEG-YRVTYTPMAPGSYLISIKYGGPYHIGGS 2330
               AG G ++ T+  P  ++ + D  E  +G Y + YT   PG+Y+I +++GG   I  S
Sbjct: 1671 AKTAGKGKVTCTVLTPDGTEAEADVIENEDGTYDIFYTAAKPGTYVIYVRFGG-VDIPNS 1729

Query: 2331 PFKARVT 2351
            PF    T
Sbjct: 1730 PFTVMAT 1736



 Score =  296 bits (758), Expect = 7e-80
 Identities = 240/890 (26%), Positives = 386/890 (43%), Gaps = 47/890 (5%)
 Frame = +3

Query: 201  KGEITGEVRMPSGKVAQPAIT--DNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQF 374
            +G++   V  P G   +  +T   +K+ T +V Y P   GLH++ + +   HI  SP + 
Sbjct: 286  QGDVMVFVEDPEGNKEEALVTPDSDKNKTYSVEYLPKVTGLHKVTVLFAGQHISKSPFEV 345

Query: 375  YVDYV--NCGHVTAYGPGL--SHGVVNKPAVFTVNTKDAGEGGLSLAIEGP---SKAEIS 533
             VD    +   VTA GPGL  +  + NKP  F + T  AG G + + +E P   +  E+ 
Sbjct: 346  NVDKAQGDASKVTAKGPGLEVASNIANKPTYFDIYTAGAGVGDIGVEVEDPQGKNTVELL 405

Query: 534  CTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARV----------TGDDSMRMS 683
              D  +      Y P+ PG + + V +    IP SPF  +V               ++  
Sbjct: 406  VEDRGNQVYRCVYKPMQPGPHVVKVSFAGDTIPKSPFVVQVGEACNPNACRASGRGLQPK 465

Query: 684  HLKVGSAADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLV 863
             +++   AD  ++        L  T+  P G EE    K  ++G     + P   G++ V
Sbjct: 466  GIRIRETADFKVDTKAAGSGELGVTIKGPKGLEELVKQKGFQDGVYAFEYYPSTQGKYSV 525

Query: 864  HVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEGHTFEPAEFIIDTRDAGYGGLS 1043
             +   G H+  SP  V +         +VR  G GLH G     A+F++++  +  G L 
Sbjct: 526  SITWGGHHIQKSPFEVQVGPE--AGMQKVRAWGPGLHGGIVGRSADFVVESIGSEVGSLG 583

Query: 1044 LSIEGPSKVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKV-TGEGRV 1220
             +IEGPS+  I  +D  DG+C V Y P EPG Y ++I   D+ +  SPF   +    G  
Sbjct: 584  FAIEGPSQAKIEYDDQNDGSCDVKYWPKEPGEYAVHIMCDDEDIKDSPFMAYIHPASGDY 643

Query: 1221 KESITRRQ---RAPSVANVGSHCDLSLKIPEISIQDMTAQVTSPSGKSHEAEIVEGENHT 1391
               + +        S   V +  + ++   +     +        G+  + ++    + T
Sbjct: 644  NPDLVQAYGPGLEKSGCIVNNLAEFTVDPKDAGKAPLKIFAQDGDGQPIDIQMKSRMDGT 703

Query: 1392 YCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAH--KVRAGGPGLERA--EA 1559
            Y   + P +   HT++V + G ++P SP++ ++G     G+H  KV+  GPG+ER+  +A
Sbjct: 704  YACSYTPVKAIKHTIAVVWGGVNIPHSPYRVSIGQ----GSHPQKVKVFGPGVERSGLKA 759

Query: 1560 GVPAEFSIWTREAGAGGLAIAVE------GPSKAEISFE--DRKDGSCGVAYVVQEPGDY 1715
              P  F++   EAG G +++ ++         + ++ F+     + +  V YV    G Y
Sbjct: 760  HEPTHFTVDCTEAGEGDVSVGIKCDARVLSDEEEDVDFDIIHNANDTFTVKYVPPAAGRY 819

Query: 1716 EVSVKFNEEHIPDSPFVVPVASPSGDARRLTVS--SLQESGLKVNQPASFAVSLNGA-KG 1886
             + V F  + IP SPF V V  PS DA ++      L ++G++  +P  F V   GA K 
Sbjct: 820  TIKVLFASQEIPTSPFRVKV-DPSHDASKVKAEGPGLSKAGVENGKPTHFTVYTKGAGKA 878

Query: 1887 AIDAKVHS--PSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRV 2060
             ++ +  S  P  A+++  + +     + V++ P + G   + V + G  IP SPF + V
Sbjct: 879  PLNVQFSSPGPGDAVKDLDIIDNYDYSHTVKYTPTQQGNMQVLVTYGGDPIPKSPFTVGV 938

Query: 2061 GEPGHGGDPGLVSAYGAGLEGGV-TGSPAEFIVNTSNAGA-GALSVTIDGPSKVKMDCQE 2234
              P       L      GLE  V  G   EF V+T  AG  G L VTI  PS+  + C  
Sbjct: 939  AAP-----LDLSRIKINGLENRVEVGKDQEFAVDTRGAGGQGKLDVTILSPSRKVVPCLV 993

Query: 2235 CP----EGYRVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSVF 2402
             P    EG    + P   G Y I + Y G + + GSP+    +                 
Sbjct: 994  APMAGREGSTAKFIPREEGLYAIDLTYDG-HPVPGSPYVVEAS----------------- 1035

Query: 2403 VDSLTKTXXXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKAGNNMLLVGV 2582
                                   +KV A G GL    VG+   FT+D   AG   L + V
Sbjct: 1036 ------------------LPPDPTKVKAHGPGLRGGLVGKPAEFTIDTKGAGTGGLGLTV 1077

Query: 2583 HGPRTPCE-EILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYR 2729
             G   PCE +I     G    SVSYL    GEY + + + + HIPGSP++
Sbjct: 1078 EG---PCEAKIECSDNGDGTCSVSYLPTKPGEYFVNILFEEVHIPGSPFK 1124



 Score =  277 bits (709), Expect = 4e-74
 Identities = 238/885 (26%), Positives = 379/885 (42%), Gaps = 40/885 (4%)
 Frame = +3

Query: 204  GEITGEVRMPSGKVAQPAITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFYVD 383
            GE+   ++ P G          +DG     Y PS  G + + I +   HI  SP +  V 
Sbjct: 485  GELGVTIKGPKGLEELVKQKGFQDGVYAFEYYPSTQGKYSVSITWGGHHIQKSPFEVQVG 544

Query: 384  -YVNCGHVTAYGPGLSHGVVNKPAVFTVNTKDAGEGGLSLAIEGPSKAEISCTDNQDGTC 560
                   V A+GPGL  G+V + A F V +  +  G L  AIEGPS+A+I   D  DG+C
Sbjct: 545  PEAGMQKVRAWGPGLHGGIVGRSADFVVESIGSEVGSLGFAIEGPSQAKIEYDDQNDGSC 604

Query: 561  SVSYLPVLPGDYSILVKYNEQHIPGSPFTARV---TGD----------DSMRMSHLKVGS 701
             V Y P  PG+Y++ +  +++ I  SPF A +   +GD            +  S   V +
Sbjct: 605  DVKYWPKEPGEYAVHIMCDDEDIKDSPFMAYIHPASGDYNPDLVQAYGPGLEKSGCIVNN 664

Query: 702  AADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNG 881
             A+  ++  +   + L        G+     +K   +G    S+ P +  +H + V   G
Sbjct: 665  LAEFTVDPKDAGKAPLKIFAQDGDGQPIDIQMKSRMDGTYACSYTPVKAIKHTIAVVWGG 724

Query: 882  QHVASSPIPVVISQSEIGDASRVRVSGRGLHEG--HTFEPAEFIIDTRDAGYGGLSLSIE 1055
             ++  SP  V I Q       +V+V G G+        EP  F +D  +AG G +S+ I+
Sbjct: 725  VNIPHSPYRVSIGQG--SHPQKVKVFGPGVERSGLKAHEPTHFTVDCTEAGEGDVSVGIK 782

Query: 1056 GPSKVDINTEDLED--------GTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVT-- 1205
              ++V  + E+  D         T  V Y P   G Y I + FA Q +P SPF VKV   
Sbjct: 783  CDARVLSDEEEDVDFDIIHNANDTFTVKYVPPAAGRYTIKVLFASQEIPTSPFRVKVDPS 842

Query: 1206 -GEGRVKESITRRQRAPSVANVGSHCDLSLKIPEISIQDMTAQVTSPSGKSHEAEIVEGE 1382
                +VK       +A       +H  +  K    +  ++      P     + +I++  
Sbjct: 843  HDASKVKAEGPGLSKAGVENGKPTHFTVYTKGAGKAPLNVQFSSPGPGDAVKDLDIIDNY 902

Query: 1383 NHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLE-RAEA 1559
            ++++ +++ P + G   V V Y G  +P SP  FTVG        +++    GLE R E 
Sbjct: 903  DYSHTVKYTPTQQGNMQVLVTYGGDPIPKSP--FTVGVAAPLDLSRIKIN--GLENRVEV 958

Query: 1560 GVPAEFSIWTREAGA-GGLAIAVEGPSK----AEISFEDRKDGSCGVAYVVQEPGDYEVS 1724
            G   EF++ TR AG  G L + +  PS+      ++    ++GS    ++ +E G Y + 
Sbjct: 959  GKDQEFAVDTRGAGGQGKLDVTILSPSRKVVPCLVAPMAGREGST-AKFIPREEGLYAID 1017

Query: 1725 VKFNEEHIPDSPFVVPVASPSGDARRLTVSSLQESGLKVNQPASFAVSLNGA-KGAIDAK 1901
            + ++   +P SP+VV  + P  D  ++        G  V +PA F +   GA  G +   
Sbjct: 1018 LTYDGHPVPGSPYVVEASLPP-DPTKVKAHGPGLRGGLVGKPAEFTIDTKGAGTGGLGLT 1076

Query: 1902 VHSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGG 2081
            V  P  A  EC  ++      +V ++P + G Y +++ F   HIPGSPFK  +  P    
Sbjct: 1077 VEGPCEAKIEC--SDNGDGTCSVSYLPTKPGEYFVNILFEEVHIPGSPFKADIEMP---F 1131

Query: 2082 DPGLVSAYGAGLEGGVTGSPAEFIVNTSNAGAGALSV--TIDGPSKVKMDCQECPEG-YR 2252
            DP  V A G GLE G  G P    V+ S AG G L +    D  +K ++  +   +G Y 
Sbjct: 1132 DPSKVVASGPGLEHGKVGEPGLLSVDCSEAGPGTLGLEAVSDSGAKAEVCIENNKDGTYA 1191

Query: 2253 VTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSVFVDSLTKTXXX 2432
            VTY P+  G Y +++KYGG   +   P + +V            +TS V           
Sbjct: 1192 VTYVPLTAGMYTLTMKYGGEL-VPHFPTRVKV--------EPAVDTSRV----------- 1231

Query: 2433 XXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVD---CSKAGNNMLLVGVHGPRTPC 2603
                          KV   G+     +      FTVD    ++ G + +   +  P    
Sbjct: 1232 --------------KVFGPGIEGKDVFREATTDFTVDSRPLTQVGGDHIKAHIANPSGAS 1277

Query: 2604 EEILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLV 2738
             E  V       Y V Y   +KG + + V + D  +P SP++V V
Sbjct: 1278 TECFVTDNADGTYQVEYTPFEKGLHVVEVTYDDVPVPNSPFKVAV 1322



 Score =  252 bits (643), Expect = 2e-66
 Identities = 201/687 (29%), Positives = 308/687 (44%), Gaps = 29/687 (4%)
 Frame = +3

Query: 759  VVPPSGREEPCLLK--RLRNGHVGISFVPKETGEHLVHVKKNGQHVASSPIPVVISQSEI 932
            V  P G +E  L+     +N    + ++PK TG H V V   GQH++ SP  V + +++ 
Sbjct: 293  VEDPEGNKEEALVTPDSDKNKTYSVEYLPKVTGLHKVTVLFAGQHISKSPFEVNVDKAQ- 351

Query: 933  GDASRVRVSGRGLHEGHTF--EPAEFIIDTRDAGYGGLSLSIEGP---SKVDINTEDLED 1097
            GDAS+V   G GL        +P  F I T  AG G + + +E P   + V++  ED  +
Sbjct: 352  GDASKVTAKGPGLEVASNIANKPTYFDIYTAGAGVGDIGVEVEDPQGKNTVELLVEDRGN 411

Query: 1098 GTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTGEGRVKESITRRQRA--PSVANVG 1271
               R  Y P +PG +++ + FA   +P SPF V+V GE     +     R   P    + 
Sbjct: 412  QVYRCVYKPMQPGPHVVKVSFAGDTIPKSPFVVQV-GEACNPNACRASGRGLQPKGIRIR 470

Query: 1272 SHCDLSLKIPEISIQDMTAQVTSPSGKSHEAEIVEGENHTYCIRFVPAEMGMHTVSVKYK 1451
               D  +        ++   +  P G     +    ++  Y   + P+  G ++VS+ + 
Sbjct: 471  ETADFKVDTKAAGSGELGVTIKGPKGLEELVKQKGFQDGVYAFEYYPSTQGKYSVSITWG 530

Query: 1452 GQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLERAEAGVPAEFSIWTREAGAGGLAIAVEG 1631
            G H+  SPF+  VGP  E G  KVRA GPGL     G  A+F + +  +  G L  A+EG
Sbjct: 531  GHHIQKSPFEVQVGP--EAGMQKVRAWGPGLHGGIVGRSADFVVESIGSEVGSLGFAIEG 588

Query: 1632 PSKAEISFEDRKDGSCGVAYVVQEPGDYEVSVKFNEEHIPDSPFVVPVASPSGDARRLTV 1811
            PS+A+I ++D+ DGSC V Y  +EPG+Y V +  ++E I DSPF+  +   SGD     V
Sbjct: 589  PSQAKIEYDDQNDGSCDVKYWPKEPGEYAVHIMCDDEDIKDSPFMAYIHPASGDYNPDLV 648

Query: 1812 SS----LQESGLKVNQPASFAVSLNGA-KGAIDAKVHSPSGALEECYVTEIDQDKYAVRF 1976
             +    L++SG  VN  A F V    A K  +        G   +  +       YA  +
Sbjct: 649  QAYGPGLEKSGCIVNNLAEFTVDPKDAGKAPLKIFAQDGDGQPIDIQMKSRMDGTYACSY 708

Query: 1977 IPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPGLVSAYGAGLE--GGVTGSPAEF 2150
             P +   + I V + G +IP SP+++ +G+  H   P  V  +G G+E  G     P  F
Sbjct: 709  TPVKAIKHTIAVVWGGVNIPHSPYRVSIGQGSH---PQKVKVFGPGVERSGLKAHEPTHF 765

Query: 2151 IVNTSNAGAGALSVTIDGPSKVKMDCQE---------CPEGYRVTYTPMAPGSYLISIKY 2303
             V+ + AG G +SV I   ++V  D +E           + + V Y P A G Y I + +
Sbjct: 766  TVDCTEAGEGDVSVGIKCDARVLSDEEEDVDFDIIHNANDTFTVKYVPPAAGRYTIKVLF 825

Query: 2304 GGPYHIGGSPFKARVTGHRLVSNHSLHETSSVFVDSLTKTXXXXXXXXXXXXXXXXSKVL 2483
                 I  SPF+ +V       +H                                SKV 
Sbjct: 826  AS-QEIPTSPFRVKVD-----PSHD------------------------------ASKVK 849

Query: 2484 AKGLGLSKAYV--GQKGSFTVDCSKAGNNMLLV--GVHGPRTPCEEILVKHVGSRLYSVS 2651
            A+G GLSKA V  G+   FTV    AG   L V     GP    +++ +       ++V 
Sbjct: 850  AEGPGLSKAGVENGKPTHFTVYTKGAGKAPLNVQFSSPGPGDAVKDLDIIDNYDYSHTVK 909

Query: 2652 YLLKDKGEYTLVVKWGDEHIPGSPYRV 2732
            Y    +G   ++V +G + IP SP+ V
Sbjct: 910  YTPTQQGNMQVLVTYGGDPIPKSPFTV 936



 Score =  222 bits (566), Expect = 1e-57
 Identities = 229/840 (27%), Positives = 359/840 (42%), Gaps = 47/840 (5%)
 Frame = +3

Query: 354  PGSPLQFYVDYVNCGHVTAYGPGL--SHGVVNKPAVFTVNTKDAGEGGLSLAIEGP--SK 521
            PG+PL+     +N     AYG G+  +  +V +PA FTV+T  AG+G + + +E P  +K
Sbjct: 244  PGAPLK---PKLNPKKARAYGRGIEPTGNMVKQPAKFTVDTISAGQGDVMVFVEDPEGNK 300

Query: 522  AEISCTDNQD--GTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARVTGDDSMRMSHLKV 695
             E   T + D   T SV YLP + G + + V +  QHI  SPF   V             
Sbjct: 301  EEALVTPDSDKNKTYSVEYLPKVTGLHKVTVLFAGQHISKSPFEVNVDKAQGDASKVTAK 360

Query: 696  GSAADIPINISE--TDLSLLTA---------TVVPPSGREEPCLLKRLRNGHV-GISFVP 839
            G   ++  NI+   T   + TA          V  P G+    LL   R   V    + P
Sbjct: 361  GPGLEVASNIANKPTYFDIYTAGAGVGDIGVEVEDPQGKNTVELLVEDRGNQVYRCVYKP 420

Query: 840  KETGEHLVHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEG--HTFEPAEFIID 1013
             + G H+V V   G  +  SP   V+   E  + +  R SGRGL        E A+F +D
Sbjct: 421  MQPGPHVVKVSFAGDTIPKSPF--VVQVGEACNPNACRASGRGLQPKGIRIRETADFKVD 478

Query: 1014 TRDAGYGGLSLSIEGPSKVD--INTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSP 1187
            T+ AG G L ++I+GP  ++  +  +  +DG     Y P+  G Y ++I +   H+  SP
Sbjct: 479  TKAAGSGELGVTIKGPKGLEELVKQKGFQDGVYAFEYYPSTQGKYSVSITWGGHHIQKSP 538

Query: 1188 FSVKVTGEGRVKESITRRQRAPSVAN--VGSHCDLSLKIPEISIQDMTAQVTSPSGKSHE 1361
            F V+V  E  +++    R   P +    VG   D  ++     +  +   +  PS    E
Sbjct: 539  FEVQVGPEAGMQKV---RAWGPGLHGGIVGRSADFVVESIGSEVGSLGFAIEGPSQAKIE 595

Query: 1362 AEIVEGENHTYC-IRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPL-GEGGAHKVRAGG 1535
                + +N   C +++ P E G + V +    + +  SPF   + P  G+     V+A G
Sbjct: 596  ---YDDQNDGSCDVKYWPKEPGEYAVHIMCDDEDIKDSPFMAYIHPASGDYNPDLVQAYG 652

Query: 1536 PGLERAEAGVP--AEFSIWTREAGAGGLAI-AVEGPSK-AEISFEDRKDGSCGVAYVVQE 1703
            PGLE++   V   AEF++  ++AG   L I A +G  +  +I  + R DG+   +Y   +
Sbjct: 653  PGLEKSGCIVNNLAEFTVDPKDAGKAPLKIFAQDGDGQPIDIQMKSRMDGTYACSYTPVK 712

Query: 1704 PGDYEVSVKFNEEHIPDSPFVVPVASPSGDAR-RLTVSSLQESGLKVNQPASFAVSLNGA 1880
               + ++V +   +IP SP+ V +   S   + ++    ++ SGLK ++P  F V    A
Sbjct: 713  AIKHTIAVVWGGVNIPHSPYRVSIGQGSHPQKVKVFGPGVERSGLKAHEPTHFTVDCTEA 772

Query: 1881 -KGAI------DAKVHSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPG 2039
             +G +      DA+V S      +  +     D + V+++P   G Y I V F    IP 
Sbjct: 773  GEGDVSVGIKCDARVLSDEEEDVDFDIIHNANDTFTVKYVPPAAGRYTIKVLFASQEIPT 832

Query: 2040 SPFKIRVGEPGHGGDPGLVSAYGAGLE--GGVTGSPAEFIVNTSNAGAGALSVTID--GP 2207
            SPF+++V +P H  D   V A G GL   G   G P  F V T  AG   L+V     GP
Sbjct: 833  SPFRVKV-DPSH--DASKVKAEGPGLSKAGVENGKPTHFTVYTKGAGKAPLNVQFSSPGP 889

Query: 2208 SKVKMD---CQECPEGYRVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHS 2378
                 D          + V YTP   G+  + + YGG   I  SPF   V          
Sbjct: 890  GDAVKDLDIIDNYDYSHTVKYTPTQQGNMQVLVTYGGD-PIPKSPFTVGVAA-------- 940

Query: 2379 LHETSSVFVDSLTKTXXXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKA- 2555
                                           S++   GL  ++  VG+   F VD   A 
Sbjct: 941  ---------------------------PLDLSRIKINGLE-NRVEVGKDQEFAVDTRGAG 972

Query: 2556 GNNMLLVGVHGPRTPCEEILVKHVGSRLYSVS-YLLKDKGEYTLVVKWGDEHIPGSPYRV 2732
            G   L V +  P       LV  +  R  S + ++ +++G Y + + +    +PGSPY V
Sbjct: 973  GQGKLDVTILSPSRKVVPCLVAPMAGREGSTAKFIPREEGLYAIDLTYDGHPVPGSPYVV 1032


>ref|XP_002697040.1| PREDICTED: filamin B, beta isoform 4 [Bos taurus].
          Length = 2602

 Score = 1313 bits (3398), Expect = 0.0
 Identities = 626/881 (71%), Positives = 744/881 (84%)
 Frame = +3

Query: 99   GQQTWAPERPLVGVNGLDVTSLRPFDLVIPFTIKKGEITGEVRMPSGKVAQPAITDNKDG 278
            G + W  E   V V+ ++    +PFDLVIPF ++KGEITGEV MPSGK A+P I DNKDG
Sbjct: 1723 GFRPWVTEEAYVPVSNMNGLGFKPFDLVIPFAVRKGEITGEVHMPSGKTAKPEIVDNKDG 1782

Query: 279  TVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFYVDYVNCGHVTAYGPGLSHGVVNKPAVF 458
            TVTVRYAP+E GLHEM I+Y   HIP SPLQFYV+Y N G V+AYGPGL +GV NK A F
Sbjct: 1783 TVTVRYAPTEVGLHEMHIKYMGSHIPESPLQFYVNYPNSGSVSAYGPGLVYGVANKTATF 1842

Query: 459  TVNTKDAGEGGLSLAIEGPSKAEISCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGS 638
            T+ T+DAGEGGL LAIEGPSKAEISC DN+DGTC+V+YLP LPGDYSILVKYN++HIPGS
Sbjct: 1843 TIVTEDAGEGGLDLAIEGPSKAEISCIDNKDGTCTVTYLPTLPGDYSILVKYNDKHIPGS 1902

Query: 639  PFTARVTGDDSMRMSHLKVGSAADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGH 818
            PFTA++T DDS R S +K+GSAAD  ++ISETDLS LTA++  PSGR+EPCLLKRL N H
Sbjct: 1903 PFTAKIT-DDSRRCSQVKLGSAADFLLDISETDLSTLTASIKAPSGRDEPCLLKRLPNNH 1961

Query: 819  VGISFVPKETGEHLVHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEGHTFEPA 998
            +GISF+P+E GEHLV +KKNG HVA+SP+ +++ QSEIGDA R +V GRGL EG TFE +
Sbjct: 1962 IGISFIPREVGEHLVSIKKNGNHVANSPVSIMVVQSEIGDARRAKVYGRGLSEGRTFEMS 2021

Query: 999  EFIIDTRDAGYGGLSLSIEGPSKVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVP 1178
            +FI+DTRDAGYGG+SL++EGPSKVDI TEDLEDGTC+V+Y PT PG YI++ KFAD+HVP
Sbjct: 2022 DFIVDTRDAGYGGISLAVEGPSKVDIQTEDLEDGTCKVSYFPTVPGVYIVSTKFADEHVP 2081

Query: 1179 GSPFSVKVTGEGRVKESITRRQRAPSVANVGSHCDLSLKIPEISIQDMTAQVTSPSGKSH 1358
            GSPF+VK++GEGRVKESITR  RAPSVA VGS CDL+LKIPEI   DM+A VTSPSG+  
Sbjct: 2082 GSPFTVKISGEGRVKESITRTSRAPSVATVGSICDLNLKIPEIDSSDMSAHVTSPSGRVT 2141

Query: 1359 EAEIVEGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGP 1538
            EAEIV    +++C+RFVP EMG+HTVSVKY+GQHV GSPFQFTVGPLGEGGAHKVRAGGP
Sbjct: 2142 EAEIVPVGKNSHCVRFVPQEMGVHTVSVKYRGQHVTGSPFQFTVGPLGEGGAHKVRAGGP 2201

Query: 1539 GLERAEAGVPAEFSIWTREAGAGGLAIAVEGPSKAEISFEDRKDGSCGVAYVVQEPGDYE 1718
            GLER EAGVPAEFSIWTREAGAGGL+IAVEGPSKAEI+F+D K+GSCGV+Y+ QEPG+YE
Sbjct: 2202 GLERGEAGVPAEFSIWTREAGAGGLSIAVEGPSKAEITFDDHKNGSCGVSYIAQEPGNYE 2261

Query: 1719 VSVKFNEEHIPDSPFVVPVASPSGDARRLTVSSLQESGLKVNQPASFAVSLNGAKGAIDA 1898
            VS+KFN+EHIP+SP+VVPV +PS DARRLTV SLQESGLKVNQPASFA+ LNGAKG IDA
Sbjct: 2262 VSIKFNDEHIPESPYVVPVIAPSDDARRLTVLSLQESGLKVNQPASFAIRLNGAKGKIDA 2321

Query: 1899 KVHSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGHG 2078
            KVHSPSGA+EEC+V+E++ DKYAVRFIP ENG++ IDVKFNG+H+ GSPFK+RVGEPG  
Sbjct: 2322 KVHSPSGAVEECHVSELEPDKYAVRFIPHENGIHTIDVKFNGSHVVGSPFKVRVGEPGQA 2381

Query: 2079 GDPGLVSAYGAGLEGGVTGSPAEFIVNTSNAGAGALSVTIDGPSKVKMDCQECPEGYRVT 2258
            G+P LVSAYGAGLEGG TG  +EF +NT+ AG G LSVTI+GPSKVKMDCQE PEGY+V 
Sbjct: 2382 GNPALVSAYGAGLEGGSTGIQSEFFINTTRAGPGTLSVTIEGPSKVKMDCQETPEGYKVM 2441

Query: 2259 YTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSVFVDSLTKTXXXXX 2438
            YTPMAPG+YLI +KYGGP HI GSPFKA+VTG RLVS  S +ETSS+ V+S+T++     
Sbjct: 2442 YTPMAPGNYLIGVKYGGPNHIVGSPFKAKVTGQRLVSPGSANETSSILVESVTRSSTETC 2501

Query: 2439 XXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKAGNNMLLVGVHGPRTPCEEILV 2618
                       SKV +KG GLSKA++GQK SF VDCSKAG+NMLL+GVHGP TPCEE+ +
Sbjct: 2502 YSAIPKASSDASKVTSKGAGLSKAFLGQKSSFLVDCSKAGSNMLLIGVHGPTTPCEEVSM 2561

Query: 2619 KHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLVP 2741
            KHVG++ Y+V+Y++K++G+Y L VKWG+EHIPGSP+ V VP
Sbjct: 2562 KHVGNQQYNVTYVVKERGDYVLAVKWGEEHIPGSPFHVTVP 2602



 Score =  429 bits (1102), Expect = e-119
 Identities = 287/893 (32%), Positives = 423/893 (47%), Gaps = 36/893 (4%)
 Frame = +3

Query: 168  PFDLVIPFTIK-----KGEITGEVRMPSGKVAQPAITDNKDGTVTVRYAPSEAGLHEMDI 332
            P  L + F I      +G +  ++    GK  +  + DNKDGT  V Y P + G + + +
Sbjct: 1533 PASLPVEFAIDARDAGEGLLAVQITDQEGKPKRAIVHDNKDGTYAVTYIPDKTGRYMIGV 1592

Query: 333  RYDNMHIPGSPLQFYVDYV-NCGHVTAYGPGLSHGVVNKPAV-FTVNTKDAGEGGLSLAI 506
             Y    IP SP +       +     A GPG++  V     V F V+ K AG+G ++  +
Sbjct: 1593 TYGGDDIPLSPYRIRATQTGDASKCLATGPGIASTVKTGEEVGFVVDAKTAGKGKVTCTV 1652

Query: 507  EGP--SKAEISCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARVTGDDSMRM 680
              P  ++AE    +N+DGT  + Y    PG Y I V++    IP SPFT   T  +   +
Sbjct: 1653 LTPDGTEAEADVIENEDGTYDIFYTAAKPGTYVIYVRFGGVDIPNSPFTVMATDGEVAAV 1712

Query: 681  SHLKVGSA-----------ADIPIN------ISETDLSL--------LTATVVPPSGREE 785
              + V +            A +P++          DL +        +T  V  PSG+  
Sbjct: 1713 KEVPVNACPPGFRPWVTEEAYVPVSNMNGLGFKPFDLVIPFAVRKGEITGEVHMPSGKTA 1772

Query: 786  PCLLKRLRNGHVGISFVPKETGEHLVHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGR 965
               +   ++G V + + P E G H +H+K  G H+  SP+   ++    G  S     G 
Sbjct: 1773 KPEIVDNKDGTVTVRYAPTEVGLHEMHIKYMGSHIPESPLQFYVNYPNSGSVS---AYGP 1829

Query: 966  GLHEGHTFEPAEFIIDTRDAGYGGLSLSIEGPSKVDINTEDLEDGTCRVTYCPTEPGNYI 1145
            GL  G   + A F I T DAG GGL L+IEGPSK +I+  D +DGTC VTY PT PG+Y 
Sbjct: 1830 GLVYGVANKTATFTIVTEDAGEGGLDLAIEGPSKAEISCIDNKDGTCTVTYLPTLPGDYS 1889

Query: 1146 INIKFADQHVPGSPFSVKVTGEGRVKESITRRQRAPSVANVGSHCDLSLKIPEISIQDMT 1325
            I +K+ D+H+PGSPF+ K+T +           R  S   +GS  D  L I E  +  +T
Sbjct: 1890 ILVKYNDKHIPGSPFTAKITDD----------SRRCSQVKLGSAADFLLDISETDLSTLT 1939

Query: 1326 AQVTSPSGKSHEAEIVEGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGE 1505
            A + +PSG+     +    N+   I F+P E+G H VS+K  G HV  SP    V     
Sbjct: 1940 ASIKAPSGRDEPCLLKRLPNNHIGISFIPREVGEHLVSIKKNGNHVANSPVSIMVVQSEI 1999

Query: 1506 GGAHKVRAGGPGLERAEAGVPAEFSIWTREAGAGGLAIAVEGPSKAEISFEDRKDGSCGV 1685
            G A + +  G GL        ++F + TR+AG GG+++AVEGPSK +I  ED +DG+C V
Sbjct: 2000 GDARRAKVYGRGLSEGRTFEMSDFIVDTRDAGYGGISLAVEGPSKVDIQTEDLEDGTCKV 2059

Query: 1686 AYVVQEPGDYEVSVKFNEEHIPDSPFVVPVASPSGDARRLTVSSLQESGLKVNQPASFAV 1865
            +Y    PG Y VS KF +EH+P SPF V ++        +T +S   S   V       +
Sbjct: 2060 SYFPTVPGVYIVSTKFADEHVPGSPFTVKISGEGRVKESITRTSRAPSVATVGSICDLNL 2119

Query: 1866 SLNGAKGA-IDAKVHSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGS 2042
             +     + + A V SPSG + E  +  + ++ + VRF+P+E GV+ + VK+ G H+ GS
Sbjct: 2120 KIPEIDSSDMSAHVTSPSGRVTEAEIVPVGKNSHCVRFVPQEMGVHTVSVKYRGQHVTGS 2179

Query: 2043 PFKIRVGEPGHGGDPGLVSAYGAGLEGGVTGSPAEFIVNTSNAGAGALSVTIDGPSKVKM 2222
            PF+  VG  G GG    V A G GLE G  G PAEF + T  AGAG LS+ ++GPSK ++
Sbjct: 2180 PFQFTVGPLGEGG-AHKVRAGGPGLERGEAGVPAEFSIWTREAGAGGLSIAVEGPSKAEI 2238

Query: 2223 DCQECPEG-YRVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSV 2399
               +   G   V+Y    PG+Y +SIK+    HI  SP+   V                 
Sbjct: 2239 TFDDHKNGSCGVSYIAQEPGNYEVSIKFNDE-HIPESPYVVPVIA--------------- 2282

Query: 2400 FVDSLTKTXXXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKAGNNMLLVG 2579
                                     ++    L  S   V Q  SF +  + A    +   
Sbjct: 2283 -------------------PSDDARRLTVLSLQESGLKVNQPASFAIRLNGA-KGKIDAK 2322

Query: 2580 VHGPRTPCEEILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLV 2738
            VH P    EE  V  +    Y+V ++  + G +T+ VK+   H+ GSP++V V
Sbjct: 2323 VHSPSGAVEECHVSELEPDKYAVRFIPHENGIHTIDVKFNGSHVVGSPFKVRV 2375



 Score =  331 bits (848), Expect = 3e-90
 Identities = 242/756 (32%), Positives = 367/756 (48%), Gaps = 39/756 (5%)
 Frame = +3

Query: 201  KGEITGEVRMPSGKVAQPAITD--NKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQF 374
            +G++   +  PS KV    +     ++G+ T ++ P E GL+ +D+ YD   +PGSP   
Sbjct: 974  QGKLDVTILSPSRKVVPCLVAPMAGREGS-TAKFIPREEGLYAIDLTYDGHPVPGSPYVV 1032

Query: 375  YVDYV-NCGHVTAYGPGLSHGVVNKPAVFTVNTKDAGEGGLSLAIEGPSKAEISCTDNQD 551
                  +   V A+GPGL  G+V KPA FT++TK AG GGL L +EGP +A+I C+DN D
Sbjct: 1033 EASLPPDPTKVKAHGPGLRGGLVGKPAEFTIDTKGAGTGGLGLTVEGPCEAKIECSDNGD 1092

Query: 552  GTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARV--------TGDDSMRMSHLKVGSAA 707
            GTCSVSYLP  PG+Y + + + E HIPGSPF A +               + H KVG   
Sbjct: 1093 GTCSVSYLPTKPGEYFVNILFEEVHIPGSPFKADIEMPFDPSKVVASGPGLEHGKVGEPG 1152

Query: 708  DIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNGQH 887
             + ++ SE     L    V  SG +    ++  ++G   +++VP   G + + +K  G+ 
Sbjct: 1153 LLSVDCSEAGPGTLGLEAVSDSGAKAEVCIENNKDGTYAVTYVPLTAGMYTLTMKYGGEL 1212

Query: 888  VASSPIPVVISQSEIGDASRVRVSGRGLHEGHTFEPA--EFIIDTR---DAGYGGLSLSI 1052
            V   P  V +  +   D SRV+V G G+     F  A  +F +D+R     G   +   I
Sbjct: 1213 VPHFPTRVKVEPAV--DTSRVKVFGPGIEGKDVFREATTDFTVDSRPLTQVGGDHIKAHI 1270

Query: 1053 EGPS--KVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVT------- 1205
              PS    +    D  DGT +V Y P E G +++ + + D  VP SPF V VT       
Sbjct: 1271 ANPSGASTECFVTDNADGTYQVEYTPFEKGLHVVEVTYDDVPVPNSPFKVAVTEGCQPSR 1330

Query: 1206 ----GEGRVKESITRRQRAPSVANVGSHCDLSLKIPEISIQDMTAQVTSPSGKSHEAEIV 1373
                G G +KE+ T +    +V   G+            I  +   V  PS    +    
Sbjct: 1331 VQAQGPG-LKEAFTNKPNVFTVVTRGA-----------GIGGLGITVEGPS--ESKINCR 1376

Query: 1374 EGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGL-ER 1550
            + ++ +    +VP   G + V++ Y G H+PGSPF+  V  + +    KV+  GPGL   
Sbjct: 1377 DNKDGSCSAEYVPFAPGDYDVNITYGGAHIPGSPFRVPVKDVVD--PSKVKIVGPGLGSG 1434

Query: 1551 AEAGVPAEFSIWTREAGAGGLAIAVEGPS--KAEISFEDRKDGSCGVAYVVQEPGDYEVS 1724
              A V   F++ + +AG   L + V GP      ++  D  DG+  V Y   + G Y VS
Sbjct: 1435 VRARVLQSFTVDSSKAGLAPLEVRVMGPRGLVEPVNVVDNGDGTHTVTYTPSQEGPYMVS 1494

Query: 1725 VKFNEEHIPDSPFVVPVASPSGDARRLTVS--SLQESGLKVNQPASFAVSLNGA-KGAID 1895
            VK+ +E IP SPF V V  P+ DA ++T S   L   G+  + P  FA+    A +G + 
Sbjct: 1495 VKYADEEIPRSPFKVKVL-PTYDASKVTASGPGLSTYGVPASLPVEFAIDARDAGEGLLA 1553

Query: 1896 AKVHSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGH 2075
             ++    G  +   V +     YAV +IP + G Y+I V + G  IP SP++IR  +   
Sbjct: 1554 VQITDQEGKPKRAIVHDNKDGTYAVTYIPDKTGRYMIGVTYGGDDIPLSPYRIRATQT-- 1611

Query: 2076 GGDPGLVSAYGAGLEGGV-TGSPAEFIVNTSNAGAGALSVTIDGP--SKVKMDCQECPEG 2246
             GD     A G G+   V TG    F+V+   AG G ++ T+  P  ++ + D  E  +G
Sbjct: 1612 -GDASKCLATGPGIASTVKTGEEVGFVVDAKTAGKGKVTCTVLTPDGTEAEADVIENEDG 1670

Query: 2247 -YRVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVT 2351
             Y + YT   PG+Y+I +++GG   I  SPF    T
Sbjct: 1671 TYDIFYTAAKPGTYVIYVRFGG-VDIPNSPFTVMAT 1705



 Score =  296 bits (758), Expect = 7e-80
 Identities = 240/890 (26%), Positives = 386/890 (43%), Gaps = 47/890 (5%)
 Frame = +3

Query: 201  KGEITGEVRMPSGKVAQPAIT--DNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQF 374
            +G++   V  P G   +  +T   +K+ T +V Y P   GLH++ + +   HI  SP + 
Sbjct: 286  QGDVMVFVEDPEGNKEEALVTPDSDKNKTYSVEYLPKVTGLHKVTVLFAGQHISKSPFEV 345

Query: 375  YVDYV--NCGHVTAYGPGL--SHGVVNKPAVFTVNTKDAGEGGLSLAIEGP---SKAEIS 533
             VD    +   VTA GPGL  +  + NKP  F + T  AG G + + +E P   +  E+ 
Sbjct: 346  NVDKAQGDASKVTAKGPGLEVASNIANKPTYFDIYTAGAGVGDIGVEVEDPQGKNTVELL 405

Query: 534  CTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARV----------TGDDSMRMS 683
              D  +      Y P+ PG + + V +    IP SPF  +V               ++  
Sbjct: 406  VEDRGNQVYRCVYKPMQPGPHVVKVSFAGDTIPKSPFVVQVGEACNPNACRASGRGLQPK 465

Query: 684  HLKVGSAADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLV 863
             +++   AD  ++        L  T+  P G EE    K  ++G     + P   G++ V
Sbjct: 466  GIRIRETADFKVDTKAAGSGELGVTIKGPKGLEELVKQKGFQDGVYAFEYYPSTQGKYSV 525

Query: 864  HVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEGHTFEPAEFIIDTRDAGYGGLS 1043
             +   G H+  SP  V +         +VR  G GLH G     A+F++++  +  G L 
Sbjct: 526  SITWGGHHIQKSPFEVQVGPE--AGMQKVRAWGPGLHGGIVGRSADFVVESIGSEVGSLG 583

Query: 1044 LSIEGPSKVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKV-TGEGRV 1220
             +IEGPS+  I  +D  DG+C V Y P EPG Y ++I   D+ +  SPF   +    G  
Sbjct: 584  FAIEGPSQAKIEYDDQNDGSCDVKYWPKEPGEYAVHIMCDDEDIKDSPFMAYIHPASGDY 643

Query: 1221 KESITRRQ---RAPSVANVGSHCDLSLKIPEISIQDMTAQVTSPSGKSHEAEIVEGENHT 1391
               + +        S   V +  + ++   +     +        G+  + ++    + T
Sbjct: 644  NPDLVQAYGPGLEKSGCIVNNLAEFTVDPKDAGKAPLKIFAQDGDGQPIDIQMKSRMDGT 703

Query: 1392 YCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAH--KVRAGGPGLERA--EA 1559
            Y   + P +   HT++V + G ++P SP++ ++G     G+H  KV+  GPG+ER+  +A
Sbjct: 704  YACSYTPVKAIKHTIAVVWGGVNIPHSPYRVSIGQ----GSHPQKVKVFGPGVERSGLKA 759

Query: 1560 GVPAEFSIWTREAGAGGLAIAVE------GPSKAEISFE--DRKDGSCGVAYVVQEPGDY 1715
              P  F++   EAG G +++ ++         + ++ F+     + +  V YV    G Y
Sbjct: 760  HEPTHFTVDCTEAGEGDVSVGIKCDARVLSDEEEDVDFDIIHNANDTFTVKYVPPAAGRY 819

Query: 1716 EVSVKFNEEHIPDSPFVVPVASPSGDARRLTVS--SLQESGLKVNQPASFAVSLNGA-KG 1886
             + V F  + IP SPF V V  PS DA ++      L ++G++  +P  F V   GA K 
Sbjct: 820  TIKVLFASQEIPTSPFRVKV-DPSHDASKVKAEGPGLSKAGVENGKPTHFTVYTKGAGKA 878

Query: 1887 AIDAKVHS--PSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRV 2060
             ++ +  S  P  A+++  + +     + V++ P + G   + V + G  IP SPF + V
Sbjct: 879  PLNVQFSSPGPGDAVKDLDIIDNYDYSHTVKYTPTQQGNMQVLVTYGGDPIPKSPFTVGV 938

Query: 2061 GEPGHGGDPGLVSAYGAGLEGGV-TGSPAEFIVNTSNAGA-GALSVTIDGPSKVKMDCQE 2234
              P       L      GLE  V  G   EF V+T  AG  G L VTI  PS+  + C  
Sbjct: 939  AAP-----LDLSRIKINGLENRVEVGKDQEFAVDTRGAGGQGKLDVTILSPSRKVVPCLV 993

Query: 2235 CP----EGYRVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSVF 2402
             P    EG    + P   G Y I + Y G + + GSP+    +                 
Sbjct: 994  APMAGREGSTAKFIPREEGLYAIDLTYDG-HPVPGSPYVVEAS----------------- 1035

Query: 2403 VDSLTKTXXXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKAGNNMLLVGV 2582
                                   +KV A G GL    VG+   FT+D   AG   L + V
Sbjct: 1036 ------------------LPPDPTKVKAHGPGLRGGLVGKPAEFTIDTKGAGTGGLGLTV 1077

Query: 2583 HGPRTPCE-EILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYR 2729
             G   PCE +I     G    SVSYL    GEY + + + + HIPGSP++
Sbjct: 1078 EG---PCEAKIECSDNGDGTCSVSYLPTKPGEYFVNILFEEVHIPGSPFK 1124



 Score =  293 bits (751), Expect = 5e-79
 Identities = 253/874 (28%), Positives = 399/874 (45%), Gaps = 52/874 (5%)
 Frame = +3

Query: 273  DGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFYVDYVNCGH-VTAYGPGLSHGVV--N 443
            DGT    Y P +A  H + + +  ++IP SP +  +   +    V  +GPG+    +  +
Sbjct: 701  DGTYACSYTPVKAIKHTIAVVWGGVNIPHSPYRVSIGQGSHPQKVKVFGPGVERSGLKAH 760

Query: 444  KPAVFTVNTKDAGEGGLSLAIEGPSKA--------EISCTDNQDGTCSVSYLPVLPGDYS 599
            +P  FTV+  +AGEG +S+ I+  ++         +     N + T +V Y+P   G Y+
Sbjct: 761  EPTHFTVDCTEAGEGDVSVGIKCDARVLSDEEEDVDFDIIHNANDTFTVKYVPPAAGRYT 820

Query: 600  ILVKYNEQHIPGSPFTARV------------------TGDDSMRMSHLKVGS--AADIPI 719
            I V +  Q IP SPF  +V                   G ++ + +H  V +  A   P+
Sbjct: 821  IKVLFASQEIPTSPFRVKVDPSHDASKVKAEGPGLSKAGVENGKPTHFTVYTKGAGKAPL 880

Query: 720  NISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNGQHVASS 899
            N+  +          P    ++  ++      H  + + P + G   V V   G  +  S
Sbjct: 881  NVQFSSPG-------PGDAVKDLDIIDNYDYSHT-VKYTPTQQGNMQVLVTYGGDPIPKS 932

Query: 900  PIPVVISQSEIGDASRVRVSGRGLHEGHTFEPAEFIIDTRDAG-YGGLSLSIEGPSKVDI 1076
            P  V ++     D SR++++G   +     +  EF +DTR AG  G L ++I  PS+  +
Sbjct: 933  PFTVGVAAPL--DLSRIKINGLE-NRVEVGKDQEFAVDTRGAGGQGKLDVTILSPSRKVV 989

Query: 1077 NT-----EDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTGEGRVKESITR- 1238
                      E  T +  + P E G Y I++ +    VPGSP+ V    E  +    T+ 
Sbjct: 990  PCLVAPMAGREGSTAK--FIPREEGLYAIDLTYDGHPVPGSPYVV----EASLPPDPTKV 1043

Query: 1239 RQRAPSVAN--VGSHCDLSLKIPEISIQDMTAQVTSPSGKSHEAEIVEGENH--TYCIRF 1406
            +   P +    VG   + ++         +   V  P     EA+I   +N   T  + +
Sbjct: 1044 KAHGPGLRGGLVGKPAEFTIDTKGAGTGGLGLTVEGPC----EAKIECSDNGDGTCSVSY 1099

Query: 1407 VPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLERAEAGVPAEFSIW 1586
            +P + G + V++ ++  H+PGSPF+  +    +    KV A GPGLE  + G P   S+ 
Sbjct: 1100 LPTKPGEYFVNILFEEVHIPGSPFKADIEMPFDPS--KVVASGPGLEHGKVGEPGLLSVD 1157

Query: 1587 TREAGAG--GLAIAVEGPSKAEISFEDRKDGSCGVAYVVQEPGDYEVSVKFNEEHIPDSP 1760
              EAG G  GL    +  +KAE+  E+ KDG+  V YV    G Y +++K+  E +P  P
Sbjct: 1158 CSEAGPGTLGLEAVSDSGAKAEVCIENNKDGTYAVTYVPLTAGMYTLTMKYGGELVPHFP 1217

Query: 1761 FVVPVASPSGDARRLTVSSLQESGLKVNQPASFAVSLNGAK------GAIDAKVHSPSGA 1922
              V V  P+ D  R+ V      G  V + A+   +++           I A + +PSGA
Sbjct: 1218 TRVKV-EPAVDTSRVKVFGPGIEGKDVFREATTDFTVDSRPLTQVGGDHIKAHIANPSGA 1276

Query: 1923 LEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPGLVSA 2102
              EC+VT+     Y V + P E G+++++V ++   +P SPFK+ V E   G  P  V A
Sbjct: 1277 STECFVTDNADGTYQVEYTPFEKGLHVVEVTYDDVPVPNSPFKVAVTE---GCQPSRVQA 1333

Query: 2103 YGAGLEGGVTGSPAEFIVNTSNAGAGALSVTIDGPSKVKMDCQECPEGY-RVTYTPMAPG 2279
             G GL+   T  P  F V T  AG G L +T++GPS+ K++C++  +G     Y P APG
Sbjct: 1334 QGPGLKEAFTNKPNVFTVVTRGAGIGGLGITVEGPSESKINCRDNKDGSCSAEYVPFAPG 1393

Query: 2280 SYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSVFVDSLTKTXXXXXXXXXXXX 2459
             Y ++I YGG  HI GSPF+  V          + + S V                    
Sbjct: 1394 DYDVNITYGGA-HIPGSPFRVPVK--------DVVDPSKV-------------------- 1424

Query: 2460 XXXXSKVLAKGLGLS-KAYVGQKGSFTVDCSKAGNNMLLVGVHGPRTPCEEILVKHVGSR 2636
                 K++  GLG   +A V Q  SFTVD SKAG   L V V GPR   E + V   G  
Sbjct: 1425 -----KIVGPGLGSGVRARVLQ--SFTVDSSKAGLAPLEVRVMGPRGLVEPVNVVDNGDG 1477

Query: 2637 LYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLV 2738
             ++V+Y    +G Y + VK+ DE IP SP++V V
Sbjct: 1478 THTVTYTPSQEGPYMVSVKYADEEIPRSPFKVKV 1511



 Score =  277 bits (709), Expect = 4e-74
 Identities = 238/885 (26%), Positives = 379/885 (42%), Gaps = 40/885 (4%)
 Frame = +3

Query: 204  GEITGEVRMPSGKVAQPAITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFYVD 383
            GE+   ++ P G          +DG     Y PS  G + + I +   HI  SP +  V 
Sbjct: 485  GELGVTIKGPKGLEELVKQKGFQDGVYAFEYYPSTQGKYSVSITWGGHHIQKSPFEVQVG 544

Query: 384  -YVNCGHVTAYGPGLSHGVVNKPAVFTVNTKDAGEGGLSLAIEGPSKAEISCTDNQDGTC 560
                   V A+GPGL  G+V + A F V +  +  G L  AIEGPS+A+I   D  DG+C
Sbjct: 545  PEAGMQKVRAWGPGLHGGIVGRSADFVVESIGSEVGSLGFAIEGPSQAKIEYDDQNDGSC 604

Query: 561  SVSYLPVLPGDYSILVKYNEQHIPGSPFTARV---TGD----------DSMRMSHLKVGS 701
             V Y P  PG+Y++ +  +++ I  SPF A +   +GD            +  S   V +
Sbjct: 605  DVKYWPKEPGEYAVHIMCDDEDIKDSPFMAYIHPASGDYNPDLVQAYGPGLEKSGCIVNN 664

Query: 702  AADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNG 881
             A+  ++  +   + L        G+     +K   +G    S+ P +  +H + V   G
Sbjct: 665  LAEFTVDPKDAGKAPLKIFAQDGDGQPIDIQMKSRMDGTYACSYTPVKAIKHTIAVVWGG 724

Query: 882  QHVASSPIPVVISQSEIGDASRVRVSGRGLHEG--HTFEPAEFIIDTRDAGYGGLSLSIE 1055
             ++  SP  V I Q       +V+V G G+        EP  F +D  +AG G +S+ I+
Sbjct: 725  VNIPHSPYRVSIGQG--SHPQKVKVFGPGVERSGLKAHEPTHFTVDCTEAGEGDVSVGIK 782

Query: 1056 GPSKVDINTEDLED--------GTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVT-- 1205
              ++V  + E+  D         T  V Y P   G Y I + FA Q +P SPF VKV   
Sbjct: 783  CDARVLSDEEEDVDFDIIHNANDTFTVKYVPPAAGRYTIKVLFASQEIPTSPFRVKVDPS 842

Query: 1206 -GEGRVKESITRRQRAPSVANVGSHCDLSLKIPEISIQDMTAQVTSPSGKSHEAEIVEGE 1382
                +VK       +A       +H  +  K    +  ++      P     + +I++  
Sbjct: 843  HDASKVKAEGPGLSKAGVENGKPTHFTVYTKGAGKAPLNVQFSSPGPGDAVKDLDIIDNY 902

Query: 1383 NHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLE-RAEA 1559
            ++++ +++ P + G   V V Y G  +P SP  FTVG        +++    GLE R E 
Sbjct: 903  DYSHTVKYTPTQQGNMQVLVTYGGDPIPKSP--FTVGVAAPLDLSRIKIN--GLENRVEV 958

Query: 1560 GVPAEFSIWTREAGA-GGLAIAVEGPSK----AEISFEDRKDGSCGVAYVVQEPGDYEVS 1724
            G   EF++ TR AG  G L + +  PS+      ++    ++GS    ++ +E G Y + 
Sbjct: 959  GKDQEFAVDTRGAGGQGKLDVTILSPSRKVVPCLVAPMAGREGST-AKFIPREEGLYAID 1017

Query: 1725 VKFNEEHIPDSPFVVPVASPSGDARRLTVSSLQESGLKVNQPASFAVSLNGA-KGAIDAK 1901
            + ++   +P SP+VV  + P  D  ++        G  V +PA F +   GA  G +   
Sbjct: 1018 LTYDGHPVPGSPYVVEASLPP-DPTKVKAHGPGLRGGLVGKPAEFTIDTKGAGTGGLGLT 1076

Query: 1902 VHSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGG 2081
            V  P  A  EC  ++      +V ++P + G Y +++ F   HIPGSPFK  +  P    
Sbjct: 1077 VEGPCEAKIEC--SDNGDGTCSVSYLPTKPGEYFVNILFEEVHIPGSPFKADIEMP---F 1131

Query: 2082 DPGLVSAYGAGLEGGVTGSPAEFIVNTSNAGAGALSV--TIDGPSKVKMDCQECPEG-YR 2252
            DP  V A G GLE G  G P    V+ S AG G L +    D  +K ++  +   +G Y 
Sbjct: 1132 DPSKVVASGPGLEHGKVGEPGLLSVDCSEAGPGTLGLEAVSDSGAKAEVCIENNKDGTYA 1191

Query: 2253 VTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSVFVDSLTKTXXX 2432
            VTY P+  G Y +++KYGG   +   P + +V            +TS V           
Sbjct: 1192 VTYVPLTAGMYTLTMKYGGEL-VPHFPTRVKV--------EPAVDTSRV----------- 1231

Query: 2433 XXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVD---CSKAGNNMLLVGVHGPRTPC 2603
                          KV   G+     +      FTVD    ++ G + +   +  P    
Sbjct: 1232 --------------KVFGPGIEGKDVFREATTDFTVDSRPLTQVGGDHIKAHIANPSGAS 1277

Query: 2604 EEILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLV 2738
             E  V       Y V Y   +KG + + V + D  +P SP++V V
Sbjct: 1278 TECFVTDNADGTYQVEYTPFEKGLHVVEVTYDDVPVPNSPFKVAV 1322



 Score =  252 bits (643), Expect = 2e-66
 Identities = 201/687 (29%), Positives = 308/687 (44%), Gaps = 29/687 (4%)
 Frame = +3

Query: 759  VVPPSGREEPCLLK--RLRNGHVGISFVPKETGEHLVHVKKNGQHVASSPIPVVISQSEI 932
            V  P G +E  L+     +N    + ++PK TG H V V   GQH++ SP  V + +++ 
Sbjct: 293  VEDPEGNKEEALVTPDSDKNKTYSVEYLPKVTGLHKVTVLFAGQHISKSPFEVNVDKAQ- 351

Query: 933  GDASRVRVSGRGLHEGHTF--EPAEFIIDTRDAGYGGLSLSIEGP---SKVDINTEDLED 1097
            GDAS+V   G GL        +P  F I T  AG G + + +E P   + V++  ED  +
Sbjct: 352  GDASKVTAKGPGLEVASNIANKPTYFDIYTAGAGVGDIGVEVEDPQGKNTVELLVEDRGN 411

Query: 1098 GTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTGEGRVKESITRRQRA--PSVANVG 1271
               R  Y P +PG +++ + FA   +P SPF V+V GE     +     R   P    + 
Sbjct: 412  QVYRCVYKPMQPGPHVVKVSFAGDTIPKSPFVVQV-GEACNPNACRASGRGLQPKGIRIR 470

Query: 1272 SHCDLSLKIPEISIQDMTAQVTSPSGKSHEAEIVEGENHTYCIRFVPAEMGMHTVSVKYK 1451
               D  +        ++   +  P G     +    ++  Y   + P+  G ++VS+ + 
Sbjct: 471  ETADFKVDTKAAGSGELGVTIKGPKGLEELVKQKGFQDGVYAFEYYPSTQGKYSVSITWG 530

Query: 1452 GQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLERAEAGVPAEFSIWTREAGAGGLAIAVEG 1631
            G H+  SPF+  VGP  E G  KVRA GPGL     G  A+F + +  +  G L  A+EG
Sbjct: 531  GHHIQKSPFEVQVGP--EAGMQKVRAWGPGLHGGIVGRSADFVVESIGSEVGSLGFAIEG 588

Query: 1632 PSKAEISFEDRKDGSCGVAYVVQEPGDYEVSVKFNEEHIPDSPFVVPVASPSGDARRLTV 1811
            PS+A+I ++D+ DGSC V Y  +EPG+Y V +  ++E I DSPF+  +   SGD     V
Sbjct: 589  PSQAKIEYDDQNDGSCDVKYWPKEPGEYAVHIMCDDEDIKDSPFMAYIHPASGDYNPDLV 648

Query: 1812 SS----LQESGLKVNQPASFAVSLNGA-KGAIDAKVHSPSGALEECYVTEIDQDKYAVRF 1976
             +    L++SG  VN  A F V    A K  +        G   +  +       YA  +
Sbjct: 649  QAYGPGLEKSGCIVNNLAEFTVDPKDAGKAPLKIFAQDGDGQPIDIQMKSRMDGTYACSY 708

Query: 1977 IPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPGLVSAYGAGLE--GGVTGSPAEF 2150
             P +   + I V + G +IP SP+++ +G+  H   P  V  +G G+E  G     P  F
Sbjct: 709  TPVKAIKHTIAVVWGGVNIPHSPYRVSIGQGSH---PQKVKVFGPGVERSGLKAHEPTHF 765

Query: 2151 IVNTSNAGAGALSVTIDGPSKVKMDCQE---------CPEGYRVTYTPMAPGSYLISIKY 2303
             V+ + AG G +SV I   ++V  D +E           + + V Y P A G Y I + +
Sbjct: 766  TVDCTEAGEGDVSVGIKCDARVLSDEEEDVDFDIIHNANDTFTVKYVPPAAGRYTIKVLF 825

Query: 2304 GGPYHIGGSPFKARVTGHRLVSNHSLHETSSVFVDSLTKTXXXXXXXXXXXXXXXXSKVL 2483
                 I  SPF+ +V       +H                                SKV 
Sbjct: 826  AS-QEIPTSPFRVKVD-----PSHD------------------------------ASKVK 849

Query: 2484 AKGLGLSKAYV--GQKGSFTVDCSKAGNNMLLV--GVHGPRTPCEEILVKHVGSRLYSVS 2651
            A+G GLSKA V  G+   FTV    AG   L V     GP    +++ +       ++V 
Sbjct: 850  AEGPGLSKAGVENGKPTHFTVYTKGAGKAPLNVQFSSPGPGDAVKDLDIIDNYDYSHTVK 909

Query: 2652 YLLKDKGEYTLVVKWGDEHIPGSPYRV 2732
            Y    +G   ++V +G + IP SP+ V
Sbjct: 910  YTPTQQGNMQVLVTYGGDPIPKSPFTV 936



 Score =  222 bits (566), Expect = 1e-57
 Identities = 229/840 (27%), Positives = 359/840 (42%), Gaps = 47/840 (5%)
 Frame = +3

Query: 354  PGSPLQFYVDYVNCGHVTAYGPGL--SHGVVNKPAVFTVNTKDAGEGGLSLAIEGP--SK 521
            PG+PL+     +N     AYG G+  +  +V +PA FTV+T  AG+G + + +E P  +K
Sbjct: 244  PGAPLK---PKLNPKKARAYGRGIEPTGNMVKQPAKFTVDTISAGQGDVMVFVEDPEGNK 300

Query: 522  AEISCTDNQD--GTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARVTGDDSMRMSHLKV 695
             E   T + D   T SV YLP + G + + V +  QHI  SPF   V             
Sbjct: 301  EEALVTPDSDKNKTYSVEYLPKVTGLHKVTVLFAGQHISKSPFEVNVDKAQGDASKVTAK 360

Query: 696  GSAADIPINISE--TDLSLLTA---------TVVPPSGREEPCLLKRLRNGHV-GISFVP 839
            G   ++  NI+   T   + TA          V  P G+    LL   R   V    + P
Sbjct: 361  GPGLEVASNIANKPTYFDIYTAGAGVGDIGVEVEDPQGKNTVELLVEDRGNQVYRCVYKP 420

Query: 840  KETGEHLVHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEG--HTFEPAEFIID 1013
             + G H+V V   G  +  SP   V+   E  + +  R SGRGL        E A+F +D
Sbjct: 421  MQPGPHVVKVSFAGDTIPKSPF--VVQVGEACNPNACRASGRGLQPKGIRIRETADFKVD 478

Query: 1014 TRDAGYGGLSLSIEGPSKVD--INTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSP 1187
            T+ AG G L ++I+GP  ++  +  +  +DG     Y P+  G Y ++I +   H+  SP
Sbjct: 479  TKAAGSGELGVTIKGPKGLEELVKQKGFQDGVYAFEYYPSTQGKYSVSITWGGHHIQKSP 538

Query: 1188 FSVKVTGEGRVKESITRRQRAPSVAN--VGSHCDLSLKIPEISIQDMTAQVTSPSGKSHE 1361
            F V+V  E  +++    R   P +    VG   D  ++     +  +   +  PS    E
Sbjct: 539  FEVQVGPEAGMQKV---RAWGPGLHGGIVGRSADFVVESIGSEVGSLGFAIEGPSQAKIE 595

Query: 1362 AEIVEGENHTYC-IRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPL-GEGGAHKVRAGG 1535
                + +N   C +++ P E G + V +    + +  SPF   + P  G+     V+A G
Sbjct: 596  ---YDDQNDGSCDVKYWPKEPGEYAVHIMCDDEDIKDSPFMAYIHPASGDYNPDLVQAYG 652

Query: 1536 PGLERAEAGVP--AEFSIWTREAGAGGLAI-AVEGPSK-AEISFEDRKDGSCGVAYVVQE 1703
            PGLE++   V   AEF++  ++AG   L I A +G  +  +I  + R DG+   +Y   +
Sbjct: 653  PGLEKSGCIVNNLAEFTVDPKDAGKAPLKIFAQDGDGQPIDIQMKSRMDGTYACSYTPVK 712

Query: 1704 PGDYEVSVKFNEEHIPDSPFVVPVASPSGDAR-RLTVSSLQESGLKVNQPASFAVSLNGA 1880
               + ++V +   +IP SP+ V +   S   + ++    ++ SGLK ++P  F V    A
Sbjct: 713  AIKHTIAVVWGGVNIPHSPYRVSIGQGSHPQKVKVFGPGVERSGLKAHEPTHFTVDCTEA 772

Query: 1881 -KGAI------DAKVHSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPG 2039
             +G +      DA+V S      +  +     D + V+++P   G Y I V F    IP 
Sbjct: 773  GEGDVSVGIKCDARVLSDEEEDVDFDIIHNANDTFTVKYVPPAAGRYTIKVLFASQEIPT 832

Query: 2040 SPFKIRVGEPGHGGDPGLVSAYGAGLE--GGVTGSPAEFIVNTSNAGAGALSVTID--GP 2207
            SPF+++V +P H  D   V A G GL   G   G P  F V T  AG   L+V     GP
Sbjct: 833  SPFRVKV-DPSH--DASKVKAEGPGLSKAGVENGKPTHFTVYTKGAGKAPLNVQFSSPGP 889

Query: 2208 SKVKMD---CQECPEGYRVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHS 2378
                 D          + V YTP   G+  + + YGG   I  SPF   V          
Sbjct: 890  GDAVKDLDIIDNYDYSHTVKYTPTQQGNMQVLVTYGGD-PIPKSPFTVGVAA-------- 940

Query: 2379 LHETSSVFVDSLTKTXXXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKA- 2555
                                           S++   GL  ++  VG+   F VD   A 
Sbjct: 941  ---------------------------PLDLSRIKINGLE-NRVEVGKDQEFAVDTRGAG 972

Query: 2556 GNNMLLVGVHGPRTPCEEILVKHVGSRLYSVS-YLLKDKGEYTLVVKWGDEHIPGSPYRV 2732
            G   L V +  P       LV  +  R  S + ++ +++G Y + + +    +PGSPY V
Sbjct: 973  GQGKLDVTILSPSRKVVPCLVAPMAGREGSTAKFIPREEGLYAIDLTYDGHPVPGSPYVV 1032


>ref|XP_002697037.1| PREDICTED: filamin B, beta isoform 1 [Bos taurus].
          Length = 2633

 Score = 1313 bits (3398), Expect = 0.0
 Identities = 626/881 (71%), Positives = 744/881 (84%)
 Frame = +3

Query: 99   GQQTWAPERPLVGVNGLDVTSLRPFDLVIPFTIKKGEITGEVRMPSGKVAQPAITDNKDG 278
            G + W  E   V V+ ++    +PFDLVIPF ++KGEITGEV MPSGK A+P I DNKDG
Sbjct: 1754 GFRPWVTEEAYVPVSNMNGLGFKPFDLVIPFAVRKGEITGEVHMPSGKTAKPEIVDNKDG 1813

Query: 279  TVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFYVDYVNCGHVTAYGPGLSHGVVNKPAVF 458
            TVTVRYAP+E GLHEM I+Y   HIP SPLQFYV+Y N G V+AYGPGL +GV NK A F
Sbjct: 1814 TVTVRYAPTEVGLHEMHIKYMGSHIPESPLQFYVNYPNSGSVSAYGPGLVYGVANKTATF 1873

Query: 459  TVNTKDAGEGGLSLAIEGPSKAEISCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGS 638
            T+ T+DAGEGGL LAIEGPSKAEISC DN+DGTC+V+YLP LPGDYSILVKYN++HIPGS
Sbjct: 1874 TIVTEDAGEGGLDLAIEGPSKAEISCIDNKDGTCTVTYLPTLPGDYSILVKYNDKHIPGS 1933

Query: 639  PFTARVTGDDSMRMSHLKVGSAADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGH 818
            PFTA++T DDS R S +K+GSAAD  ++ISETDLS LTA++  PSGR+EPCLLKRL N H
Sbjct: 1934 PFTAKIT-DDSRRCSQVKLGSAADFLLDISETDLSTLTASIKAPSGRDEPCLLKRLPNNH 1992

Query: 819  VGISFVPKETGEHLVHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEGHTFEPA 998
            +GISF+P+E GEHLV +KKNG HVA+SP+ +++ QSEIGDA R +V GRGL EG TFE +
Sbjct: 1993 IGISFIPREVGEHLVSIKKNGNHVANSPVSIMVVQSEIGDARRAKVYGRGLSEGRTFEMS 2052

Query: 999  EFIIDTRDAGYGGLSLSIEGPSKVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVP 1178
            +FI+DTRDAGYGG+SL++EGPSKVDI TEDLEDGTC+V+Y PT PG YI++ KFAD+HVP
Sbjct: 2053 DFIVDTRDAGYGGISLAVEGPSKVDIQTEDLEDGTCKVSYFPTVPGVYIVSTKFADEHVP 2112

Query: 1179 GSPFSVKVTGEGRVKESITRRQRAPSVANVGSHCDLSLKIPEISIQDMTAQVTSPSGKSH 1358
            GSPF+VK++GEGRVKESITR  RAPSVA VGS CDL+LKIPEI   DM+A VTSPSG+  
Sbjct: 2113 GSPFTVKISGEGRVKESITRTSRAPSVATVGSICDLNLKIPEIDSSDMSAHVTSPSGRVT 2172

Query: 1359 EAEIVEGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGP 1538
            EAEIV    +++C+RFVP EMG+HTVSVKY+GQHV GSPFQFTVGPLGEGGAHKVRAGGP
Sbjct: 2173 EAEIVPVGKNSHCVRFVPQEMGVHTVSVKYRGQHVTGSPFQFTVGPLGEGGAHKVRAGGP 2232

Query: 1539 GLERAEAGVPAEFSIWTREAGAGGLAIAVEGPSKAEISFEDRKDGSCGVAYVVQEPGDYE 1718
            GLER EAGVPAEFSIWTREAGAGGL+IAVEGPSKAEI+F+D K+GSCGV+Y+ QEPG+YE
Sbjct: 2233 GLERGEAGVPAEFSIWTREAGAGGLSIAVEGPSKAEITFDDHKNGSCGVSYIAQEPGNYE 2292

Query: 1719 VSVKFNEEHIPDSPFVVPVASPSGDARRLTVSSLQESGLKVNQPASFAVSLNGAKGAIDA 1898
            VS+KFN+EHIP+SP+VVPV +PS DARRLTV SLQESGLKVNQPASFA+ LNGAKG IDA
Sbjct: 2293 VSIKFNDEHIPESPYVVPVIAPSDDARRLTVLSLQESGLKVNQPASFAIRLNGAKGKIDA 2352

Query: 1899 KVHSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGHG 2078
            KVHSPSGA+EEC+V+E++ DKYAVRFIP ENG++ IDVKFNG+H+ GSPFK+RVGEPG  
Sbjct: 2353 KVHSPSGAVEECHVSELEPDKYAVRFIPHENGIHTIDVKFNGSHVVGSPFKVRVGEPGQA 2412

Query: 2079 GDPGLVSAYGAGLEGGVTGSPAEFIVNTSNAGAGALSVTIDGPSKVKMDCQECPEGYRVT 2258
            G+P LVSAYGAGLEGG TG  +EF +NT+ AG G LSVTI+GPSKVKMDCQE PEGY+V 
Sbjct: 2413 GNPALVSAYGAGLEGGSTGIQSEFFINTTRAGPGTLSVTIEGPSKVKMDCQETPEGYKVM 2472

Query: 2259 YTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSVFVDSLTKTXXXXX 2438
            YTPMAPG+YLI +KYGGP HI GSPFKA+VTG RLVS  S +ETSS+ V+S+T++     
Sbjct: 2473 YTPMAPGNYLIGVKYGGPNHIVGSPFKAKVTGQRLVSPGSANETSSILVESVTRSSTETC 2532

Query: 2439 XXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKAGNNMLLVGVHGPRTPCEEILV 2618
                       SKV +KG GLSKA++GQK SF VDCSKAG+NMLL+GVHGP TPCEE+ +
Sbjct: 2533 YSAIPKASSDASKVTSKGAGLSKAFLGQKSSFLVDCSKAGSNMLLIGVHGPTTPCEEVSM 2592

Query: 2619 KHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLVP 2741
            KHVG++ Y+V+Y++K++G+Y L VKWG+EHIPGSP+ V VP
Sbjct: 2593 KHVGNQQYNVTYVVKERGDYVLAVKWGEEHIPGSPFHVTVP 2633



 Score =  429 bits (1102), Expect = e-119
 Identities = 287/893 (32%), Positives = 423/893 (47%), Gaps = 36/893 (4%)
 Frame = +3

Query: 168  PFDLVIPFTIK-----KGEITGEVRMPSGKVAQPAITDNKDGTVTVRYAPSEAGLHEMDI 332
            P  L + F I      +G +  ++    GK  +  + DNKDGT  V Y P + G + + +
Sbjct: 1564 PASLPVEFAIDARDAGEGLLAVQITDQEGKPKRAIVHDNKDGTYAVTYIPDKTGRYMIGV 1623

Query: 333  RYDNMHIPGSPLQFYVDYV-NCGHVTAYGPGLSHGVVNKPAV-FTVNTKDAGEGGLSLAI 506
             Y    IP SP +       +     A GPG++  V     V F V+ K AG+G ++  +
Sbjct: 1624 TYGGDDIPLSPYRIRATQTGDASKCLATGPGIASTVKTGEEVGFVVDAKTAGKGKVTCTV 1683

Query: 507  EGP--SKAEISCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARVTGDDSMRM 680
              P  ++AE    +N+DGT  + Y    PG Y I V++    IP SPFT   T  +   +
Sbjct: 1684 LTPDGTEAEADVIENEDGTYDIFYTAAKPGTYVIYVRFGGVDIPNSPFTVMATDGEVAAV 1743

Query: 681  SHLKVGSA-----------ADIPIN------ISETDLSL--------LTATVVPPSGREE 785
              + V +            A +P++          DL +        +T  V  PSG+  
Sbjct: 1744 KEVPVNACPPGFRPWVTEEAYVPVSNMNGLGFKPFDLVIPFAVRKGEITGEVHMPSGKTA 1803

Query: 786  PCLLKRLRNGHVGISFVPKETGEHLVHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGR 965
               +   ++G V + + P E G H +H+K  G H+  SP+   ++    G  S     G 
Sbjct: 1804 KPEIVDNKDGTVTVRYAPTEVGLHEMHIKYMGSHIPESPLQFYVNYPNSGSVS---AYGP 1860

Query: 966  GLHEGHTFEPAEFIIDTRDAGYGGLSLSIEGPSKVDINTEDLEDGTCRVTYCPTEPGNYI 1145
            GL  G   + A F I T DAG GGL L+IEGPSK +I+  D +DGTC VTY PT PG+Y 
Sbjct: 1861 GLVYGVANKTATFTIVTEDAGEGGLDLAIEGPSKAEISCIDNKDGTCTVTYLPTLPGDYS 1920

Query: 1146 INIKFADQHVPGSPFSVKVTGEGRVKESITRRQRAPSVANVGSHCDLSLKIPEISIQDMT 1325
            I +K+ D+H+PGSPF+ K+T +           R  S   +GS  D  L I E  +  +T
Sbjct: 1921 ILVKYNDKHIPGSPFTAKITDD----------SRRCSQVKLGSAADFLLDISETDLSTLT 1970

Query: 1326 AQVTSPSGKSHEAEIVEGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGE 1505
            A + +PSG+     +    N+   I F+P E+G H VS+K  G HV  SP    V     
Sbjct: 1971 ASIKAPSGRDEPCLLKRLPNNHIGISFIPREVGEHLVSIKKNGNHVANSPVSIMVVQSEI 2030

Query: 1506 GGAHKVRAGGPGLERAEAGVPAEFSIWTREAGAGGLAIAVEGPSKAEISFEDRKDGSCGV 1685
            G A + +  G GL        ++F + TR+AG GG+++AVEGPSK +I  ED +DG+C V
Sbjct: 2031 GDARRAKVYGRGLSEGRTFEMSDFIVDTRDAGYGGISLAVEGPSKVDIQTEDLEDGTCKV 2090

Query: 1686 AYVVQEPGDYEVSVKFNEEHIPDSPFVVPVASPSGDARRLTVSSLQESGLKVNQPASFAV 1865
            +Y    PG Y VS KF +EH+P SPF V ++        +T +S   S   V       +
Sbjct: 2091 SYFPTVPGVYIVSTKFADEHVPGSPFTVKISGEGRVKESITRTSRAPSVATVGSICDLNL 2150

Query: 1866 SLNGAKGA-IDAKVHSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGS 2042
             +     + + A V SPSG + E  +  + ++ + VRF+P+E GV+ + VK+ G H+ GS
Sbjct: 2151 KIPEIDSSDMSAHVTSPSGRVTEAEIVPVGKNSHCVRFVPQEMGVHTVSVKYRGQHVTGS 2210

Query: 2043 PFKIRVGEPGHGGDPGLVSAYGAGLEGGVTGSPAEFIVNTSNAGAGALSVTIDGPSKVKM 2222
            PF+  VG  G GG    V A G GLE G  G PAEF + T  AGAG LS+ ++GPSK ++
Sbjct: 2211 PFQFTVGPLGEGG-AHKVRAGGPGLERGEAGVPAEFSIWTREAGAGGLSIAVEGPSKAEI 2269

Query: 2223 DCQECPEG-YRVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSV 2399
               +   G   V+Y    PG+Y +SIK+    HI  SP+   V                 
Sbjct: 2270 TFDDHKNGSCGVSYIAQEPGNYEVSIKFNDE-HIPESPYVVPVIA--------------- 2313

Query: 2400 FVDSLTKTXXXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKAGNNMLLVG 2579
                                     ++    L  S   V Q  SF +  + A    +   
Sbjct: 2314 -------------------PSDDARRLTVLSLQESGLKVNQPASFAIRLNGA-KGKIDAK 2353

Query: 2580 VHGPRTPCEEILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLV 2738
            VH P    EE  V  +    Y+V ++  + G +T+ VK+   H+ GSP++V V
Sbjct: 2354 VHSPSGAVEECHVSELEPDKYAVRFIPHENGIHTIDVKFNGSHVVGSPFKVRV 2406



 Score =  320 bits (820), Expect = 5e-87
 Identities = 242/787 (30%), Positives = 368/787 (46%), Gaps = 70/787 (8%)
 Frame = +3

Query: 201  KGEITGEVRMPSGKVAQPAITD--NKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQF 374
            +G++   +  PS KV    +     ++G+ T ++ P E GL+ +D+ YD   +PGSP   
Sbjct: 974  QGKLDVTILSPSRKVVPCLVAPMAGREGS-TAKFIPREEGLYAIDLTYDGHPVPGSPYVV 1032

Query: 375  YVDYV-NCGHVTAYGPGLSHGVVNKPAVFTVNTKDAGEGGLSLAIEGPSKAEISCTDNQD 551
                  +   V A+GPGL  G+V KPA FT++TK AG GGL L +EGP +A+I C+DN D
Sbjct: 1033 EASLPPDPTKVKAHGPGLRGGLVGKPAEFTIDTKGAGTGGLGLTVEGPCEAKIECSDNGD 1092

Query: 552  GTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARV--------TGDDSMRMSHLKVGSAA 707
            GTCSVSYLP  PG+Y + + + E HIPGSPF A +               + H KVG   
Sbjct: 1093 GTCSVSYLPTKPGEYFVNILFEEVHIPGSPFKADIEMPFDPSKVVASGPGLEHGKVGEPG 1152

Query: 708  DIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNGQH 887
             + ++ SE     L    V  SG +    ++  ++G   +++VP   G + + +K  G+ 
Sbjct: 1153 LLSVDCSEAGPGTLGLEAVSDSGAKAEVCIENNKDGTYAVTYVPLTAGMYTLTMKYGGEL 1212

Query: 888  VASSPIPVVISQSEIGDASRVRVSGRGLHEGHTFEPA--EFIIDTR---DAGYGGLSLSI 1052
            V   P  V +  +   D SRV+V G G+     F  A  +F +D+R     G   +   I
Sbjct: 1213 VPHFPTRVKVEPAV--DTSRVKVFGPGIEGKDVFREATTDFTVDSRPLTQVGGDHIKAHI 1270

Query: 1053 EGPS--KVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVT------- 1205
              PS    +    D  DGT +V Y P E G +++ + + D  VP SPF V VT       
Sbjct: 1271 ANPSGASTECFVTDNADGTYQVEYTPFEKGLHVVEVTYDDVPVPNSPFKVAVTEGCQPSR 1330

Query: 1206 ----GEGRVKESITRRQRAPSVANVGSHCDLSLKIPEISIQDMTAQVTSPSGKSHEAEIV 1373
                G G +KE+ T +    +V   G+            I  +   V  PS    +    
Sbjct: 1331 VQAQGPG-LKEAFTNKPNVFTVVTRGA-----------GIGGLGITVEGPS--ESKINCR 1376

Query: 1374 EGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGL-ER 1550
            + ++ +    +VP   G + V++ Y G H+PGSPF+  V  + +    KV+  GPGL   
Sbjct: 1377 DNKDGSCSAEYVPFAPGDYDVNITYGGAHIPGSPFRVPVKDVVD--PSKVKIVGPGLGSG 1434

Query: 1551 AEAGVPAEFSIWTREAGAGGLAIAVEGPSKAE---------------------------- 1646
              A V   F++ + +AG   L + V GP   +                            
Sbjct: 1435 VRARVLQSFTVDSSKAGLAPLEVRVMGPRADQTISWSRRSPLKAISGFFKRDRKGDFMET 1494

Query: 1647 -----ISFEDRKDGSCGVAYVVQEPGDYEVSVKFNEEHIPDSPFVVPVASPSGDARRLTV 1811
                 ++  D  DG+  V Y   + G Y VSVK+ +E IP SPF V V  P+ DA ++T 
Sbjct: 1495 GLVEPVNVVDNGDGTHTVTYTPSQEGPYMVSVKYADEEIPRSPFKVKVL-PTYDASKVTA 1553

Query: 1812 S--SLQESGLKVNQPASFAVSLNGA-KGAIDAKVHSPSGALEECYVTEIDQDKYAVRFIP 1982
            S   L   G+  + P  FA+    A +G +  ++    G  +   V +     YAV +IP
Sbjct: 1554 SGPGLSTYGVPASLPVEFAIDARDAGEGLLAVQITDQEGKPKRAIVHDNKDGTYAVTYIP 1613

Query: 1983 RENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPGLVSAYGAGLEGGV-TGSPAEFIVN 2159
             + G Y+I V + G  IP SP++IR  +    GD     A G G+   V TG    F+V+
Sbjct: 1614 DKTGRYMIGVTYGGDDIPLSPYRIRATQT---GDASKCLATGPGIASTVKTGEEVGFVVD 1670

Query: 2160 TSNAGAGALSVTIDGP--SKVKMDCQECPEG-YRVTYTPMAPGSYLISIKYGGPYHIGGS 2330
               AG G ++ T+  P  ++ + D  E  +G Y + YT   PG+Y+I +++GG   I  S
Sbjct: 1671 AKTAGKGKVTCTVLTPDGTEAEADVIENEDGTYDIFYTAAKPGTYVIYVRFGG-VDIPNS 1729

Query: 2331 PFKARVT 2351
            PF    T
Sbjct: 1730 PFTVMAT 1736



 Score =  296 bits (758), Expect = 7e-80
 Identities = 240/890 (26%), Positives = 386/890 (43%), Gaps = 47/890 (5%)
 Frame = +3

Query: 201  KGEITGEVRMPSGKVAQPAIT--DNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQF 374
            +G++   V  P G   +  +T   +K+ T +V Y P   GLH++ + +   HI  SP + 
Sbjct: 286  QGDVMVFVEDPEGNKEEALVTPDSDKNKTYSVEYLPKVTGLHKVTVLFAGQHISKSPFEV 345

Query: 375  YVDYV--NCGHVTAYGPGL--SHGVVNKPAVFTVNTKDAGEGGLSLAIEGP---SKAEIS 533
             VD    +   VTA GPGL  +  + NKP  F + T  AG G + + +E P   +  E+ 
Sbjct: 346  NVDKAQGDASKVTAKGPGLEVASNIANKPTYFDIYTAGAGVGDIGVEVEDPQGKNTVELL 405

Query: 534  CTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARV----------TGDDSMRMS 683
              D  +      Y P+ PG + + V +    IP SPF  +V               ++  
Sbjct: 406  VEDRGNQVYRCVYKPMQPGPHVVKVSFAGDTIPKSPFVVQVGEACNPNACRASGRGLQPK 465

Query: 684  HLKVGSAADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLV 863
             +++   AD  ++        L  T+  P G EE    K  ++G     + P   G++ V
Sbjct: 466  GIRIRETADFKVDTKAAGSGELGVTIKGPKGLEELVKQKGFQDGVYAFEYYPSTQGKYSV 525

Query: 864  HVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEGHTFEPAEFIIDTRDAGYGGLS 1043
             +   G H+  SP  V +         +VR  G GLH G     A+F++++  +  G L 
Sbjct: 526  SITWGGHHIQKSPFEVQVGPE--AGMQKVRAWGPGLHGGIVGRSADFVVESIGSEVGSLG 583

Query: 1044 LSIEGPSKVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKV-TGEGRV 1220
             +IEGPS+  I  +D  DG+C V Y P EPG Y ++I   D+ +  SPF   +    G  
Sbjct: 584  FAIEGPSQAKIEYDDQNDGSCDVKYWPKEPGEYAVHIMCDDEDIKDSPFMAYIHPASGDY 643

Query: 1221 KESITRRQ---RAPSVANVGSHCDLSLKIPEISIQDMTAQVTSPSGKSHEAEIVEGENHT 1391
               + +        S   V +  + ++   +     +        G+  + ++    + T
Sbjct: 644  NPDLVQAYGPGLEKSGCIVNNLAEFTVDPKDAGKAPLKIFAQDGDGQPIDIQMKSRMDGT 703

Query: 1392 YCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAH--KVRAGGPGLERA--EA 1559
            Y   + P +   HT++V + G ++P SP++ ++G     G+H  KV+  GPG+ER+  +A
Sbjct: 704  YACSYTPVKAIKHTIAVVWGGVNIPHSPYRVSIGQ----GSHPQKVKVFGPGVERSGLKA 759

Query: 1560 GVPAEFSIWTREAGAGGLAIAVE------GPSKAEISFE--DRKDGSCGVAYVVQEPGDY 1715
              P  F++   EAG G +++ ++         + ++ F+     + +  V YV    G Y
Sbjct: 760  HEPTHFTVDCTEAGEGDVSVGIKCDARVLSDEEEDVDFDIIHNANDTFTVKYVPPAAGRY 819

Query: 1716 EVSVKFNEEHIPDSPFVVPVASPSGDARRLTVS--SLQESGLKVNQPASFAVSLNGA-KG 1886
             + V F  + IP SPF V V  PS DA ++      L ++G++  +P  F V   GA K 
Sbjct: 820  TIKVLFASQEIPTSPFRVKV-DPSHDASKVKAEGPGLSKAGVENGKPTHFTVYTKGAGKA 878

Query: 1887 AIDAKVHS--PSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRV 2060
             ++ +  S  P  A+++  + +     + V++ P + G   + V + G  IP SPF + V
Sbjct: 879  PLNVQFSSPGPGDAVKDLDIIDNYDYSHTVKYTPTQQGNMQVLVTYGGDPIPKSPFTVGV 938

Query: 2061 GEPGHGGDPGLVSAYGAGLEGGV-TGSPAEFIVNTSNAGA-GALSVTIDGPSKVKMDCQE 2234
              P       L      GLE  V  G   EF V+T  AG  G L VTI  PS+  + C  
Sbjct: 939  AAP-----LDLSRIKINGLENRVEVGKDQEFAVDTRGAGGQGKLDVTILSPSRKVVPCLV 993

Query: 2235 CP----EGYRVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSVF 2402
             P    EG    + P   G Y I + Y G + + GSP+    +                 
Sbjct: 994  APMAGREGSTAKFIPREEGLYAIDLTYDG-HPVPGSPYVVEAS----------------- 1035

Query: 2403 VDSLTKTXXXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKAGNNMLLVGV 2582
                                   +KV A G GL    VG+   FT+D   AG   L + V
Sbjct: 1036 ------------------LPPDPTKVKAHGPGLRGGLVGKPAEFTIDTKGAGTGGLGLTV 1077

Query: 2583 HGPRTPCE-EILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYR 2729
             G   PCE +I     G    SVSYL    GEY + + + + HIPGSP++
Sbjct: 1078 EG---PCEAKIECSDNGDGTCSVSYLPTKPGEYFVNILFEEVHIPGSPFK 1124



 Score =  277 bits (709), Expect = 4e-74
 Identities = 238/885 (26%), Positives = 379/885 (42%), Gaps = 40/885 (4%)
 Frame = +3

Query: 204  GEITGEVRMPSGKVAQPAITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFYVD 383
            GE+   ++ P G          +DG     Y PS  G + + I +   HI  SP +  V 
Sbjct: 485  GELGVTIKGPKGLEELVKQKGFQDGVYAFEYYPSTQGKYSVSITWGGHHIQKSPFEVQVG 544

Query: 384  -YVNCGHVTAYGPGLSHGVVNKPAVFTVNTKDAGEGGLSLAIEGPSKAEISCTDNQDGTC 560
                   V A+GPGL  G+V + A F V +  +  G L  AIEGPS+A+I   D  DG+C
Sbjct: 545  PEAGMQKVRAWGPGLHGGIVGRSADFVVESIGSEVGSLGFAIEGPSQAKIEYDDQNDGSC 604

Query: 561  SVSYLPVLPGDYSILVKYNEQHIPGSPFTARV---TGD----------DSMRMSHLKVGS 701
             V Y P  PG+Y++ +  +++ I  SPF A +   +GD            +  S   V +
Sbjct: 605  DVKYWPKEPGEYAVHIMCDDEDIKDSPFMAYIHPASGDYNPDLVQAYGPGLEKSGCIVNN 664

Query: 702  AADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNG 881
             A+  ++  +   + L        G+     +K   +G    S+ P +  +H + V   G
Sbjct: 665  LAEFTVDPKDAGKAPLKIFAQDGDGQPIDIQMKSRMDGTYACSYTPVKAIKHTIAVVWGG 724

Query: 882  QHVASSPIPVVISQSEIGDASRVRVSGRGLHEG--HTFEPAEFIIDTRDAGYGGLSLSIE 1055
             ++  SP  V I Q       +V+V G G+        EP  F +D  +AG G +S+ I+
Sbjct: 725  VNIPHSPYRVSIGQG--SHPQKVKVFGPGVERSGLKAHEPTHFTVDCTEAGEGDVSVGIK 782

Query: 1056 GPSKVDINTEDLED--------GTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVT-- 1205
              ++V  + E+  D         T  V Y P   G Y I + FA Q +P SPF VKV   
Sbjct: 783  CDARVLSDEEEDVDFDIIHNANDTFTVKYVPPAAGRYTIKVLFASQEIPTSPFRVKVDPS 842

Query: 1206 -GEGRVKESITRRQRAPSVANVGSHCDLSLKIPEISIQDMTAQVTSPSGKSHEAEIVEGE 1382
                +VK       +A       +H  +  K    +  ++      P     + +I++  
Sbjct: 843  HDASKVKAEGPGLSKAGVENGKPTHFTVYTKGAGKAPLNVQFSSPGPGDAVKDLDIIDNY 902

Query: 1383 NHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLE-RAEA 1559
            ++++ +++ P + G   V V Y G  +P SP  FTVG        +++    GLE R E 
Sbjct: 903  DYSHTVKYTPTQQGNMQVLVTYGGDPIPKSP--FTVGVAAPLDLSRIKIN--GLENRVEV 958

Query: 1560 GVPAEFSIWTREAGA-GGLAIAVEGPSK----AEISFEDRKDGSCGVAYVVQEPGDYEVS 1724
            G   EF++ TR AG  G L + +  PS+      ++    ++GS    ++ +E G Y + 
Sbjct: 959  GKDQEFAVDTRGAGGQGKLDVTILSPSRKVVPCLVAPMAGREGST-AKFIPREEGLYAID 1017

Query: 1725 VKFNEEHIPDSPFVVPVASPSGDARRLTVSSLQESGLKVNQPASFAVSLNGA-KGAIDAK 1901
            + ++   +P SP+VV  + P  D  ++        G  V +PA F +   GA  G +   
Sbjct: 1018 LTYDGHPVPGSPYVVEASLPP-DPTKVKAHGPGLRGGLVGKPAEFTIDTKGAGTGGLGLT 1076

Query: 1902 VHSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGG 2081
            V  P  A  EC  ++      +V ++P + G Y +++ F   HIPGSPFK  +  P    
Sbjct: 1077 VEGPCEAKIEC--SDNGDGTCSVSYLPTKPGEYFVNILFEEVHIPGSPFKADIEMP---F 1131

Query: 2082 DPGLVSAYGAGLEGGVTGSPAEFIVNTSNAGAGALSV--TIDGPSKVKMDCQECPEG-YR 2252
            DP  V A G GLE G  G P    V+ S AG G L +    D  +K ++  +   +G Y 
Sbjct: 1132 DPSKVVASGPGLEHGKVGEPGLLSVDCSEAGPGTLGLEAVSDSGAKAEVCIENNKDGTYA 1191

Query: 2253 VTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSVFVDSLTKTXXX 2432
            VTY P+  G Y +++KYGG   +   P + +V            +TS V           
Sbjct: 1192 VTYVPLTAGMYTLTMKYGGEL-VPHFPTRVKV--------EPAVDTSRV----------- 1231

Query: 2433 XXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVD---CSKAGNNMLLVGVHGPRTPC 2603
                          KV   G+     +      FTVD    ++ G + +   +  P    
Sbjct: 1232 --------------KVFGPGIEGKDVFREATTDFTVDSRPLTQVGGDHIKAHIANPSGAS 1277

Query: 2604 EEILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLV 2738
             E  V       Y V Y   +KG + + V + D  +P SP++V V
Sbjct: 1278 TECFVTDNADGTYQVEYTPFEKGLHVVEVTYDDVPVPNSPFKVAV 1322



 Score =  252 bits (643), Expect = 2e-66
 Identities = 201/687 (29%), Positives = 308/687 (44%), Gaps = 29/687 (4%)
 Frame = +3

Query: 759  VVPPSGREEPCLLK--RLRNGHVGISFVPKETGEHLVHVKKNGQHVASSPIPVVISQSEI 932
            V  P G +E  L+     +N    + ++PK TG H V V   GQH++ SP  V + +++ 
Sbjct: 293  VEDPEGNKEEALVTPDSDKNKTYSVEYLPKVTGLHKVTVLFAGQHISKSPFEVNVDKAQ- 351

Query: 933  GDASRVRVSGRGLHEGHTF--EPAEFIIDTRDAGYGGLSLSIEGP---SKVDINTEDLED 1097
            GDAS+V   G GL        +P  F I T  AG G + + +E P   + V++  ED  +
Sbjct: 352  GDASKVTAKGPGLEVASNIANKPTYFDIYTAGAGVGDIGVEVEDPQGKNTVELLVEDRGN 411

Query: 1098 GTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTGEGRVKESITRRQRA--PSVANVG 1271
               R  Y P +PG +++ + FA   +P SPF V+V GE     +     R   P    + 
Sbjct: 412  QVYRCVYKPMQPGPHVVKVSFAGDTIPKSPFVVQV-GEACNPNACRASGRGLQPKGIRIR 470

Query: 1272 SHCDLSLKIPEISIQDMTAQVTSPSGKSHEAEIVEGENHTYCIRFVPAEMGMHTVSVKYK 1451
               D  +        ++   +  P G     +    ++  Y   + P+  G ++VS+ + 
Sbjct: 471  ETADFKVDTKAAGSGELGVTIKGPKGLEELVKQKGFQDGVYAFEYYPSTQGKYSVSITWG 530

Query: 1452 GQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLERAEAGVPAEFSIWTREAGAGGLAIAVEG 1631
            G H+  SPF+  VGP  E G  KVRA GPGL     G  A+F + +  +  G L  A+EG
Sbjct: 531  GHHIQKSPFEVQVGP--EAGMQKVRAWGPGLHGGIVGRSADFVVESIGSEVGSLGFAIEG 588

Query: 1632 PSKAEISFEDRKDGSCGVAYVVQEPGDYEVSVKFNEEHIPDSPFVVPVASPSGDARRLTV 1811
            PS+A+I ++D+ DGSC V Y  +EPG+Y V +  ++E I DSPF+  +   SGD     V
Sbjct: 589  PSQAKIEYDDQNDGSCDVKYWPKEPGEYAVHIMCDDEDIKDSPFMAYIHPASGDYNPDLV 648

Query: 1812 SS----LQESGLKVNQPASFAVSLNGA-KGAIDAKVHSPSGALEECYVTEIDQDKYAVRF 1976
             +    L++SG  VN  A F V    A K  +        G   +  +       YA  +
Sbjct: 649  QAYGPGLEKSGCIVNNLAEFTVDPKDAGKAPLKIFAQDGDGQPIDIQMKSRMDGTYACSY 708

Query: 1977 IPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPGLVSAYGAGLE--GGVTGSPAEF 2150
             P +   + I V + G +IP SP+++ +G+  H   P  V  +G G+E  G     P  F
Sbjct: 709  TPVKAIKHTIAVVWGGVNIPHSPYRVSIGQGSH---PQKVKVFGPGVERSGLKAHEPTHF 765

Query: 2151 IVNTSNAGAGALSVTIDGPSKVKMDCQE---------CPEGYRVTYTPMAPGSYLISIKY 2303
             V+ + AG G +SV I   ++V  D +E           + + V Y P A G Y I + +
Sbjct: 766  TVDCTEAGEGDVSVGIKCDARVLSDEEEDVDFDIIHNANDTFTVKYVPPAAGRYTIKVLF 825

Query: 2304 GGPYHIGGSPFKARVTGHRLVSNHSLHETSSVFVDSLTKTXXXXXXXXXXXXXXXXSKVL 2483
                 I  SPF+ +V       +H                                SKV 
Sbjct: 826  AS-QEIPTSPFRVKVD-----PSHD------------------------------ASKVK 849

Query: 2484 AKGLGLSKAYV--GQKGSFTVDCSKAGNNMLLV--GVHGPRTPCEEILVKHVGSRLYSVS 2651
            A+G GLSKA V  G+   FTV    AG   L V     GP    +++ +       ++V 
Sbjct: 850  AEGPGLSKAGVENGKPTHFTVYTKGAGKAPLNVQFSSPGPGDAVKDLDIIDNYDYSHTVK 909

Query: 2652 YLLKDKGEYTLVVKWGDEHIPGSPYRV 2732
            Y    +G   ++V +G + IP SP+ V
Sbjct: 910  YTPTQQGNMQVLVTYGGDPIPKSPFTV 936



 Score =  222 bits (566), Expect = 1e-57
 Identities = 229/840 (27%), Positives = 359/840 (42%), Gaps = 47/840 (5%)
 Frame = +3

Query: 354  PGSPLQFYVDYVNCGHVTAYGPGL--SHGVVNKPAVFTVNTKDAGEGGLSLAIEGP--SK 521
            PG+PL+     +N     AYG G+  +  +V +PA FTV+T  AG+G + + +E P  +K
Sbjct: 244  PGAPLK---PKLNPKKARAYGRGIEPTGNMVKQPAKFTVDTISAGQGDVMVFVEDPEGNK 300

Query: 522  AEISCTDNQD--GTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARVTGDDSMRMSHLKV 695
             E   T + D   T SV YLP + G + + V +  QHI  SPF   V             
Sbjct: 301  EEALVTPDSDKNKTYSVEYLPKVTGLHKVTVLFAGQHISKSPFEVNVDKAQGDASKVTAK 360

Query: 696  GSAADIPINISE--TDLSLLTA---------TVVPPSGREEPCLLKRLRNGHV-GISFVP 839
            G   ++  NI+   T   + TA          V  P G+    LL   R   V    + P
Sbjct: 361  GPGLEVASNIANKPTYFDIYTAGAGVGDIGVEVEDPQGKNTVELLVEDRGNQVYRCVYKP 420

Query: 840  KETGEHLVHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEG--HTFEPAEFIID 1013
             + G H+V V   G  +  SP   V+   E  + +  R SGRGL        E A+F +D
Sbjct: 421  MQPGPHVVKVSFAGDTIPKSPF--VVQVGEACNPNACRASGRGLQPKGIRIRETADFKVD 478

Query: 1014 TRDAGYGGLSLSIEGPSKVD--INTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSP 1187
            T+ AG G L ++I+GP  ++  +  +  +DG     Y P+  G Y ++I +   H+  SP
Sbjct: 479  TKAAGSGELGVTIKGPKGLEELVKQKGFQDGVYAFEYYPSTQGKYSVSITWGGHHIQKSP 538

Query: 1188 FSVKVTGEGRVKESITRRQRAPSVAN--VGSHCDLSLKIPEISIQDMTAQVTSPSGKSHE 1361
            F V+V  E  +++    R   P +    VG   D  ++     +  +   +  PS    E
Sbjct: 539  FEVQVGPEAGMQKV---RAWGPGLHGGIVGRSADFVVESIGSEVGSLGFAIEGPSQAKIE 595

Query: 1362 AEIVEGENHTYC-IRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPL-GEGGAHKVRAGG 1535
                + +N   C +++ P E G + V +    + +  SPF   + P  G+     V+A G
Sbjct: 596  ---YDDQNDGSCDVKYWPKEPGEYAVHIMCDDEDIKDSPFMAYIHPASGDYNPDLVQAYG 652

Query: 1536 PGLERAEAGVP--AEFSIWTREAGAGGLAI-AVEGPSK-AEISFEDRKDGSCGVAYVVQE 1703
            PGLE++   V   AEF++  ++AG   L I A +G  +  +I  + R DG+   +Y   +
Sbjct: 653  PGLEKSGCIVNNLAEFTVDPKDAGKAPLKIFAQDGDGQPIDIQMKSRMDGTYACSYTPVK 712

Query: 1704 PGDYEVSVKFNEEHIPDSPFVVPVASPSGDAR-RLTVSSLQESGLKVNQPASFAVSLNGA 1880
               + ++V +   +IP SP+ V +   S   + ++    ++ SGLK ++P  F V    A
Sbjct: 713  AIKHTIAVVWGGVNIPHSPYRVSIGQGSHPQKVKVFGPGVERSGLKAHEPTHFTVDCTEA 772

Query: 1881 -KGAI------DAKVHSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPG 2039
             +G +      DA+V S      +  +     D + V+++P   G Y I V F    IP 
Sbjct: 773  GEGDVSVGIKCDARVLSDEEEDVDFDIIHNANDTFTVKYVPPAAGRYTIKVLFASQEIPT 832

Query: 2040 SPFKIRVGEPGHGGDPGLVSAYGAGLE--GGVTGSPAEFIVNTSNAGAGALSVTID--GP 2207
            SPF+++V +P H  D   V A G GL   G   G P  F V T  AG   L+V     GP
Sbjct: 833  SPFRVKV-DPSH--DASKVKAEGPGLSKAGVENGKPTHFTVYTKGAGKAPLNVQFSSPGP 889

Query: 2208 SKVKMD---CQECPEGYRVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHS 2378
                 D          + V YTP   G+  + + YGG   I  SPF   V          
Sbjct: 890  GDAVKDLDIIDNYDYSHTVKYTPTQQGNMQVLVTYGGD-PIPKSPFTVGVAA-------- 940

Query: 2379 LHETSSVFVDSLTKTXXXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKA- 2555
                                           S++   GL  ++  VG+   F VD   A 
Sbjct: 941  ---------------------------PLDLSRIKINGLE-NRVEVGKDQEFAVDTRGAG 972

Query: 2556 GNNMLLVGVHGPRTPCEEILVKHVGSRLYSVS-YLLKDKGEYTLVVKWGDEHIPGSPYRV 2732
            G   L V +  P       LV  +  R  S + ++ +++G Y + + +    +PGSPY V
Sbjct: 973  GQGKLDVTILSPSRKVVPCLVAPMAGREGSTAKFIPREEGLYAIDLTYDGHPVPGSPYVV 1032


>ref|XP_877592.3| PREDICTED: filamin B, beta isoform 7 [Bos taurus].
          Length = 2602

 Score = 1313 bits (3398), Expect = 0.0
 Identities = 626/881 (71%), Positives = 744/881 (84%)
 Frame = +3

Query: 99   GQQTWAPERPLVGVNGLDVTSLRPFDLVIPFTIKKGEITGEVRMPSGKVAQPAITDNKDG 278
            G + W  E   V V+ ++    +PFDLVIPF ++KGEITGEV MPSGK A+P I DNKDG
Sbjct: 1723 GFRPWVTEEAYVPVSNMNGLGFKPFDLVIPFAVRKGEITGEVHMPSGKTAKPEIVDNKDG 1782

Query: 279  TVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFYVDYVNCGHVTAYGPGLSHGVVNKPAVF 458
            TVTVRYAP+E GLHEM I+Y   HIP SPLQFYV+Y N G V+AYGPGL +GV NK A F
Sbjct: 1783 TVTVRYAPTEVGLHEMHIKYMGSHIPESPLQFYVNYPNSGSVSAYGPGLVYGVANKTATF 1842

Query: 459  TVNTKDAGEGGLSLAIEGPSKAEISCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGS 638
            T+ T+DAGEGGL LAIEGPSKAEISC DN+DGTC+V+YLP LPGDYSILVKYN++HIPGS
Sbjct: 1843 TIVTEDAGEGGLDLAIEGPSKAEISCIDNKDGTCTVTYLPTLPGDYSILVKYNDKHIPGS 1902

Query: 639  PFTARVTGDDSMRMSHLKVGSAADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGH 818
            PFTA++T DDS R S +K+GSAAD  ++ISETDLS LTA++  PSGR+EPCLLKRL N H
Sbjct: 1903 PFTAKIT-DDSRRCSQVKLGSAADFLLDISETDLSTLTASIKAPSGRDEPCLLKRLPNNH 1961

Query: 819  VGISFVPKETGEHLVHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEGHTFEPA 998
            +GISF+P+E GEHLV +KKNG HVA+SP+ +++ QSEIGDA R +V GRGL EG TFE +
Sbjct: 1962 IGISFIPREVGEHLVSIKKNGNHVANSPVSIMVVQSEIGDARRAKVYGRGLSEGRTFEMS 2021

Query: 999  EFIIDTRDAGYGGLSLSIEGPSKVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVP 1178
            +FI+DTRDAGYGG+SL++EGPSKVDI TEDLEDGTC+V+Y PT PG YI++ KFAD+HVP
Sbjct: 2022 DFIVDTRDAGYGGISLAVEGPSKVDIQTEDLEDGTCKVSYFPTVPGVYIVSTKFADEHVP 2081

Query: 1179 GSPFSVKVTGEGRVKESITRRQRAPSVANVGSHCDLSLKIPEISIQDMTAQVTSPSGKSH 1358
            GSPF+VK++GEGRVKESITR  RAPSVA VGS CDL+LKIPEI   DM+A VTSPSG+  
Sbjct: 2082 GSPFTVKISGEGRVKESITRTSRAPSVATVGSICDLNLKIPEIDSSDMSAHVTSPSGRVT 2141

Query: 1359 EAEIVEGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGP 1538
            EAEIV    +++C+RFVP EMG+HTVSVKY+GQHV GSPFQFTVGPLGEGGAHKVRAGGP
Sbjct: 2142 EAEIVPVGKNSHCVRFVPQEMGVHTVSVKYRGQHVTGSPFQFTVGPLGEGGAHKVRAGGP 2201

Query: 1539 GLERAEAGVPAEFSIWTREAGAGGLAIAVEGPSKAEISFEDRKDGSCGVAYVVQEPGDYE 1718
            GLER EAGVPAEFSIWTREAGAGGL+IAVEGPSKAEI+F+D K+GSCGV+Y+ QEPG+YE
Sbjct: 2202 GLERGEAGVPAEFSIWTREAGAGGLSIAVEGPSKAEITFDDHKNGSCGVSYIAQEPGNYE 2261

Query: 1719 VSVKFNEEHIPDSPFVVPVASPSGDARRLTVSSLQESGLKVNQPASFAVSLNGAKGAIDA 1898
            VS+KFN+EHIP+SP+VVPV +PS DARRLTV SLQESGLKVNQPASFA+ LNGAKG IDA
Sbjct: 2262 VSIKFNDEHIPESPYVVPVIAPSDDARRLTVLSLQESGLKVNQPASFAIRLNGAKGKIDA 2321

Query: 1899 KVHSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGHG 2078
            KVHSPSGA+EEC+V+E++ DKYAVRFIP ENG++ IDVKFNG+H+ GSPFK+RVGEPG  
Sbjct: 2322 KVHSPSGAVEECHVSELEPDKYAVRFIPHENGIHTIDVKFNGSHVVGSPFKVRVGEPGQA 2381

Query: 2079 GDPGLVSAYGAGLEGGVTGSPAEFIVNTSNAGAGALSVTIDGPSKVKMDCQECPEGYRVT 2258
            G+P LVSAYGAGLEGG TG  +EF +NT+ AG G LSVTI+GPSKVKMDCQE PEGY+V 
Sbjct: 2382 GNPALVSAYGAGLEGGSTGIQSEFFINTTRAGPGTLSVTIEGPSKVKMDCQETPEGYKVM 2441

Query: 2259 YTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSVFVDSLTKTXXXXX 2438
            YTPMAPG+YLI +KYGGP HI GSPFKA+VTG RLVS  S +ETSS+ V+S+T++     
Sbjct: 2442 YTPMAPGNYLIGVKYGGPNHIVGSPFKAKVTGQRLVSPGSANETSSILVESVTRSSTETC 2501

Query: 2439 XXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKAGNNMLLVGVHGPRTPCEEILV 2618
                       SKV +KG GLSKA++GQK SF VDCSKAG+NMLL+GVHGP TPCEE+ +
Sbjct: 2502 YSAIPKASSDASKVTSKGAGLSKAFLGQKSSFLVDCSKAGSNMLLIGVHGPTTPCEEVSM 2561

Query: 2619 KHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLVP 2741
            KHVG++ Y+V+Y++K++G+Y L VKWG+EHIPGSP+ V VP
Sbjct: 2562 KHVGNQQYNVTYVVKERGDYVLAVKWGEEHIPGSPFHVTVP 2602



 Score =  429 bits (1102), Expect = e-119
 Identities = 287/893 (32%), Positives = 423/893 (47%), Gaps = 36/893 (4%)
 Frame = +3

Query: 168  PFDLVIPFTIK-----KGEITGEVRMPSGKVAQPAITDNKDGTVTVRYAPSEAGLHEMDI 332
            P  L + F I      +G +  ++    GK  +  + DNKDGT  V Y P + G + + +
Sbjct: 1533 PASLPVEFAIDARDAGEGLLAVQITDQEGKPKRAIVHDNKDGTYAVTYIPDKTGRYMIGV 1592

Query: 333  RYDNMHIPGSPLQFYVDYV-NCGHVTAYGPGLSHGVVNKPAV-FTVNTKDAGEGGLSLAI 506
             Y    IP SP +       +     A GPG++  V     V F V+ K AG+G ++  +
Sbjct: 1593 TYGGDDIPLSPYRIRATQTGDASKCLATGPGIASTVKTGEEVGFVVDAKTAGKGKVTCTV 1652

Query: 507  EGP--SKAEISCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARVTGDDSMRM 680
              P  ++AE    +N+DGT  + Y    PG Y I V++    IP SPFT   T  +   +
Sbjct: 1653 LTPDGTEAEADVIENEDGTYDIFYTAAKPGTYVIYVRFGGVDIPNSPFTVMATDGEVAAV 1712

Query: 681  SHLKVGSA-----------ADIPIN------ISETDLSL--------LTATVVPPSGREE 785
              + V +            A +P++          DL +        +T  V  PSG+  
Sbjct: 1713 KEVPVNACPPGFRPWVTEEAYVPVSNMNGLGFKPFDLVIPFAVRKGEITGEVHMPSGKTA 1772

Query: 786  PCLLKRLRNGHVGISFVPKETGEHLVHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGR 965
               +   ++G V + + P E G H +H+K  G H+  SP+   ++    G  S     G 
Sbjct: 1773 KPEIVDNKDGTVTVRYAPTEVGLHEMHIKYMGSHIPESPLQFYVNYPNSGSVS---AYGP 1829

Query: 966  GLHEGHTFEPAEFIIDTRDAGYGGLSLSIEGPSKVDINTEDLEDGTCRVTYCPTEPGNYI 1145
            GL  G   + A F I T DAG GGL L+IEGPSK +I+  D +DGTC VTY PT PG+Y 
Sbjct: 1830 GLVYGVANKTATFTIVTEDAGEGGLDLAIEGPSKAEISCIDNKDGTCTVTYLPTLPGDYS 1889

Query: 1146 INIKFADQHVPGSPFSVKVTGEGRVKESITRRQRAPSVANVGSHCDLSLKIPEISIQDMT 1325
            I +K+ D+H+PGSPF+ K+T +           R  S   +GS  D  L I E  +  +T
Sbjct: 1890 ILVKYNDKHIPGSPFTAKITDD----------SRRCSQVKLGSAADFLLDISETDLSTLT 1939

Query: 1326 AQVTSPSGKSHEAEIVEGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGE 1505
            A + +PSG+     +    N+   I F+P E+G H VS+K  G HV  SP    V     
Sbjct: 1940 ASIKAPSGRDEPCLLKRLPNNHIGISFIPREVGEHLVSIKKNGNHVANSPVSIMVVQSEI 1999

Query: 1506 GGAHKVRAGGPGLERAEAGVPAEFSIWTREAGAGGLAIAVEGPSKAEISFEDRKDGSCGV 1685
            G A + +  G GL        ++F + TR+AG GG+++AVEGPSK +I  ED +DG+C V
Sbjct: 2000 GDARRAKVYGRGLSEGRTFEMSDFIVDTRDAGYGGISLAVEGPSKVDIQTEDLEDGTCKV 2059

Query: 1686 AYVVQEPGDYEVSVKFNEEHIPDSPFVVPVASPSGDARRLTVSSLQESGLKVNQPASFAV 1865
            +Y    PG Y VS KF +EH+P SPF V ++        +T +S   S   V       +
Sbjct: 2060 SYFPTVPGVYIVSTKFADEHVPGSPFTVKISGEGRVKESITRTSRAPSVATVGSICDLNL 2119

Query: 1866 SLNGAKGA-IDAKVHSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGS 2042
             +     + + A V SPSG + E  +  + ++ + VRF+P+E GV+ + VK+ G H+ GS
Sbjct: 2120 KIPEIDSSDMSAHVTSPSGRVTEAEIVPVGKNSHCVRFVPQEMGVHTVSVKYRGQHVTGS 2179

Query: 2043 PFKIRVGEPGHGGDPGLVSAYGAGLEGGVTGSPAEFIVNTSNAGAGALSVTIDGPSKVKM 2222
            PF+  VG  G GG    V A G GLE G  G PAEF + T  AGAG LS+ ++GPSK ++
Sbjct: 2180 PFQFTVGPLGEGG-AHKVRAGGPGLERGEAGVPAEFSIWTREAGAGGLSIAVEGPSKAEI 2238

Query: 2223 DCQECPEG-YRVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSV 2399
               +   G   V+Y    PG+Y +SIK+    HI  SP+   V                 
Sbjct: 2239 TFDDHKNGSCGVSYIAQEPGNYEVSIKFNDE-HIPESPYVVPVIA--------------- 2282

Query: 2400 FVDSLTKTXXXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKAGNNMLLVG 2579
                                     ++    L  S   V Q  SF +  + A    +   
Sbjct: 2283 -------------------PSDDARRLTVLSLQESGLKVNQPASFAIRLNGA-KGKIDAK 2322

Query: 2580 VHGPRTPCEEILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLV 2738
            VH P    EE  V  +    Y+V ++  + G +T+ VK+   H+ GSP++V V
Sbjct: 2323 VHSPSGAVEECHVSELEPDKYAVRFIPHENGIHTIDVKFNGSHVVGSPFKVRV 2375



 Score =  331 bits (848), Expect = 3e-90
 Identities = 242/756 (32%), Positives = 367/756 (48%), Gaps = 39/756 (5%)
 Frame = +3

Query: 201  KGEITGEVRMPSGKVAQPAITD--NKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQF 374
            +G++   +  PS KV    +     ++G+ T ++ P E GL+ +D+ YD   +PGSP   
Sbjct: 974  QGKLDVTILSPSRKVVPCLVAPMAGREGS-TAKFIPREEGLYAIDLTYDGHPVPGSPYVV 1032

Query: 375  YVDYV-NCGHVTAYGPGLSHGVVNKPAVFTVNTKDAGEGGLSLAIEGPSKAEISCTDNQD 551
                  +   V A+GPGL  G+V KPA FT++TK AG GGL L +EGP +A+I C+DN D
Sbjct: 1033 EASLPPDPTKVKAHGPGLRGGLVGKPAEFTIDTKGAGTGGLGLTVEGPCEAKIECSDNGD 1092

Query: 552  GTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARV--------TGDDSMRMSHLKVGSAA 707
            GTCSVSYLP  PG+Y + + + E HIPGSPF A +               + H KVG   
Sbjct: 1093 GTCSVSYLPTKPGEYFVNILFEEVHIPGSPFKADIEMPFDPSKVVASGPGLEHGKVGEPG 1152

Query: 708  DIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNGQH 887
             + ++ SE     L    V  SG +    ++  ++G   +++VP   G + + +K  G+ 
Sbjct: 1153 LLSVDCSEAGPGTLGLEAVSDSGAKAEVCIENNKDGTYAVTYVPLTAGMYTLTMKYGGEL 1212

Query: 888  VASSPIPVVISQSEIGDASRVRVSGRGLHEGHTFEPA--EFIIDTR---DAGYGGLSLSI 1052
            V   P  V +  +   D SRV+V G G+     F  A  +F +D+R     G   +   I
Sbjct: 1213 VPHFPTRVKVEPAV--DTSRVKVFGPGIEGKDVFREATTDFTVDSRPLTQVGGDHIKAHI 1270

Query: 1053 EGPS--KVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVT------- 1205
              PS    +    D  DGT +V Y P E G +++ + + D  VP SPF V VT       
Sbjct: 1271 ANPSGASTECFVTDNADGTYQVEYTPFEKGLHVVEVTYDDVPVPNSPFKVAVTEGCQPSR 1330

Query: 1206 ----GEGRVKESITRRQRAPSVANVGSHCDLSLKIPEISIQDMTAQVTSPSGKSHEAEIV 1373
                G G +KE+ T +    +V   G+            I  +   V  PS    +    
Sbjct: 1331 VQAQGPG-LKEAFTNKPNVFTVVTRGA-----------GIGGLGITVEGPS--ESKINCR 1376

Query: 1374 EGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGL-ER 1550
            + ++ +    +VP   G + V++ Y G H+PGSPF+  V  + +    KV+  GPGL   
Sbjct: 1377 DNKDGSCSAEYVPFAPGDYDVNITYGGAHIPGSPFRVPVKDVVD--PSKVKIVGPGLGSG 1434

Query: 1551 AEAGVPAEFSIWTREAGAGGLAIAVEGPS--KAEISFEDRKDGSCGVAYVVQEPGDYEVS 1724
              A V   F++ + +AG   L + V GP      ++  D  DG+  V Y   + G Y VS
Sbjct: 1435 VRARVLQSFTVDSSKAGLAPLEVRVMGPRGLVEPVNVVDNGDGTHTVTYTPSQEGPYMVS 1494

Query: 1725 VKFNEEHIPDSPFVVPVASPSGDARRLTVS--SLQESGLKVNQPASFAVSLNGA-KGAID 1895
            VK+ +E IP SPF V V  P+ DA ++T S   L   G+  + P  FA+    A +G + 
Sbjct: 1495 VKYADEEIPRSPFKVKVL-PTYDASKVTASGPGLSTYGVPASLPVEFAIDARDAGEGLLA 1553

Query: 1896 AKVHSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGH 2075
             ++    G  +   V +     YAV +IP + G Y+I V + G  IP SP++IR  +   
Sbjct: 1554 VQITDQEGKPKRAIVHDNKDGTYAVTYIPDKTGRYMIGVTYGGDDIPLSPYRIRATQT-- 1611

Query: 2076 GGDPGLVSAYGAGLEGGV-TGSPAEFIVNTSNAGAGALSVTIDGP--SKVKMDCQECPEG 2246
             GD     A G G+   V TG    F+V+   AG G ++ T+  P  ++ + D  E  +G
Sbjct: 1612 -GDASKCLATGPGIASTVKTGEEVGFVVDAKTAGKGKVTCTVLTPDGTEAEADVIENEDG 1670

Query: 2247 -YRVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVT 2351
             Y + YT   PG+Y+I +++GG   I  SPF    T
Sbjct: 1671 TYDIFYTAAKPGTYVIYVRFGG-VDIPNSPFTVMAT 1705



 Score =  296 bits (758), Expect = 7e-80
 Identities = 240/890 (26%), Positives = 386/890 (43%), Gaps = 47/890 (5%)
 Frame = +3

Query: 201  KGEITGEVRMPSGKVAQPAIT--DNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQF 374
            +G++   V  P G   +  +T   +K+ T +V Y P   GLH++ + +   HI  SP + 
Sbjct: 286  QGDVMVFVEDPEGNKEEALVTPDSDKNKTYSVEYLPKVTGLHKVTVLFAGQHISKSPFEV 345

Query: 375  YVDYV--NCGHVTAYGPGL--SHGVVNKPAVFTVNTKDAGEGGLSLAIEGP---SKAEIS 533
             VD    +   VTA GPGL  +  + NKP  F + T  AG G + + +E P   +  E+ 
Sbjct: 346  NVDKAQGDASKVTAKGPGLEVASNIANKPTYFDIYTAGAGVGDIGVEVEDPQGKNTVELL 405

Query: 534  CTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARV----------TGDDSMRMS 683
              D  +      Y P+ PG + + V +    IP SPF  +V               ++  
Sbjct: 406  VEDRGNQVYRCVYKPMQPGPHVVKVSFAGDTIPKSPFVVQVGEACNPNACRASGRGLQPK 465

Query: 684  HLKVGSAADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLV 863
             +++   AD  ++        L  T+  P G EE    K  ++G     + P   G++ V
Sbjct: 466  GIRIRETADFKVDTKAAGSGELGVTIKGPKGLEELVKQKGFQDGVYAFEYYPSTQGKYSV 525

Query: 864  HVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEGHTFEPAEFIIDTRDAGYGGLS 1043
             +   G H+  SP  V +         +VR  G GLH G     A+F++++  +  G L 
Sbjct: 526  SITWGGHHIQKSPFEVQVGPE--AGMQKVRAWGPGLHGGIVGRSADFVVESIGSEVGSLG 583

Query: 1044 LSIEGPSKVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKV-TGEGRV 1220
             +IEGPS+  I  +D  DG+C V Y P EPG Y ++I   D+ +  SPF   +    G  
Sbjct: 584  FAIEGPSQAKIEYDDQNDGSCDVKYWPKEPGEYAVHIMCDDEDIKDSPFMAYIHPASGDY 643

Query: 1221 KESITRRQ---RAPSVANVGSHCDLSLKIPEISIQDMTAQVTSPSGKSHEAEIVEGENHT 1391
               + +        S   V +  + ++   +     +        G+  + ++    + T
Sbjct: 644  NPDLVQAYGPGLEKSGCIVNNLAEFTVDPKDAGKAPLKIFAQDGDGQPIDIQMKSRMDGT 703

Query: 1392 YCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAH--KVRAGGPGLERA--EA 1559
            Y   + P +   HT++V + G ++P SP++ ++G     G+H  KV+  GPG+ER+  +A
Sbjct: 704  YACSYTPVKAIKHTIAVVWGGVNIPHSPYRVSIGQ----GSHPQKVKVFGPGVERSGLKA 759

Query: 1560 GVPAEFSIWTREAGAGGLAIAVE------GPSKAEISFE--DRKDGSCGVAYVVQEPGDY 1715
              P  F++   EAG G +++ ++         + ++ F+     + +  V YV    G Y
Sbjct: 760  HEPTHFTVDCTEAGEGDVSVGIKCDARVLSDEEEDVDFDIIHNANDTFTVKYVPPAAGRY 819

Query: 1716 EVSVKFNEEHIPDSPFVVPVASPSGDARRLTVS--SLQESGLKVNQPASFAVSLNGA-KG 1886
             + V F  + IP SPF V V  PS DA ++      L ++G++  +P  F V   GA K 
Sbjct: 820  TIKVLFASQEIPTSPFRVKV-DPSHDASKVKAEGPGLSKAGVENGKPTHFTVYTKGAGKA 878

Query: 1887 AIDAKVHS--PSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRV 2060
             ++ +  S  P  A+++  + +     + V++ P + G   + V + G  IP SPF + V
Sbjct: 879  PLNVQFSSPGPGDAVKDLDIIDNYDYSHTVKYTPTQQGNMQVLVTYGGDPIPKSPFTVGV 938

Query: 2061 GEPGHGGDPGLVSAYGAGLEGGV-TGSPAEFIVNTSNAGA-GALSVTIDGPSKVKMDCQE 2234
              P       L      GLE  V  G   EF V+T  AG  G L VTI  PS+  + C  
Sbjct: 939  AAP-----LDLSRIKINGLENRVEVGKDQEFAVDTRGAGGQGKLDVTILSPSRKVVPCLV 993

Query: 2235 CP----EGYRVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSVF 2402
             P    EG    + P   G Y I + Y G + + GSP+    +                 
Sbjct: 994  APMAGREGSTAKFIPREEGLYAIDLTYDG-HPVPGSPYVVEAS----------------- 1035

Query: 2403 VDSLTKTXXXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKAGNNMLLVGV 2582
                                   +KV A G GL    VG+   FT+D   AG   L + V
Sbjct: 1036 ------------------LPPDPTKVKAHGPGLRGGLVGKPAEFTIDTKGAGTGGLGLTV 1077

Query: 2583 HGPRTPCE-EILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYR 2729
             G   PCE +I     G    SVSYL    GEY + + + + HIPGSP++
Sbjct: 1078 EG---PCEAKIECSDNGDGTCSVSYLPTKPGEYFVNILFEEVHIPGSPFK 1124



 Score =  293 bits (751), Expect = 5e-79
 Identities = 253/874 (28%), Positives = 399/874 (45%), Gaps = 52/874 (5%)
 Frame = +3

Query: 273  DGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFYVDYVNCGH-VTAYGPGLSHGVV--N 443
            DGT    Y P +A  H + + +  ++IP SP +  +   +    V  +GPG+    +  +
Sbjct: 701  DGTYACSYTPVKAIKHTIAVVWGGVNIPHSPYRVSIGQGSHPQKVKVFGPGVERSGLKAH 760

Query: 444  KPAVFTVNTKDAGEGGLSLAIEGPSKA--------EISCTDNQDGTCSVSYLPVLPGDYS 599
            +P  FTV+  +AGEG +S+ I+  ++         +     N + T +V Y+P   G Y+
Sbjct: 761  EPTHFTVDCTEAGEGDVSVGIKCDARVLSDEEEDVDFDIIHNANDTFTVKYVPPAAGRYT 820

Query: 600  ILVKYNEQHIPGSPFTARV------------------TGDDSMRMSHLKVGS--AADIPI 719
            I V +  Q IP SPF  +V                   G ++ + +H  V +  A   P+
Sbjct: 821  IKVLFASQEIPTSPFRVKVDPSHDASKVKAEGPGLSKAGVENGKPTHFTVYTKGAGKAPL 880

Query: 720  NISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNGQHVASS 899
            N+  +          P    ++  ++      H  + + P + G   V V   G  +  S
Sbjct: 881  NVQFSSPG-------PGDAVKDLDIIDNYDYSHT-VKYTPTQQGNMQVLVTYGGDPIPKS 932

Query: 900  PIPVVISQSEIGDASRVRVSGRGLHEGHTFEPAEFIIDTRDAG-YGGLSLSIEGPSKVDI 1076
            P  V ++     D SR++++G   +     +  EF +DTR AG  G L ++I  PS+  +
Sbjct: 933  PFTVGVAAPL--DLSRIKINGLE-NRVEVGKDQEFAVDTRGAGGQGKLDVTILSPSRKVV 989

Query: 1077 NT-----EDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTGEGRVKESITR- 1238
                      E  T +  + P E G Y I++ +    VPGSP+ V    E  +    T+ 
Sbjct: 990  PCLVAPMAGREGSTAK--FIPREEGLYAIDLTYDGHPVPGSPYVV----EASLPPDPTKV 1043

Query: 1239 RQRAPSVAN--VGSHCDLSLKIPEISIQDMTAQVTSPSGKSHEAEIVEGENH--TYCIRF 1406
            +   P +    VG   + ++         +   V  P     EA+I   +N   T  + +
Sbjct: 1044 KAHGPGLRGGLVGKPAEFTIDTKGAGTGGLGLTVEGPC----EAKIECSDNGDGTCSVSY 1099

Query: 1407 VPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLERAEAGVPAEFSIW 1586
            +P + G + V++ ++  H+PGSPF+  +    +    KV A GPGLE  + G P   S+ 
Sbjct: 1100 LPTKPGEYFVNILFEEVHIPGSPFKADIEMPFDPS--KVVASGPGLEHGKVGEPGLLSVD 1157

Query: 1587 TREAGAG--GLAIAVEGPSKAEISFEDRKDGSCGVAYVVQEPGDYEVSVKFNEEHIPDSP 1760
              EAG G  GL    +  +KAE+  E+ KDG+  V YV    G Y +++K+  E +P  P
Sbjct: 1158 CSEAGPGTLGLEAVSDSGAKAEVCIENNKDGTYAVTYVPLTAGMYTLTMKYGGELVPHFP 1217

Query: 1761 FVVPVASPSGDARRLTVSSLQESGLKVNQPASFAVSLNGAK------GAIDAKVHSPSGA 1922
              V V  P+ D  R+ V      G  V + A+   +++           I A + +PSGA
Sbjct: 1218 TRVKV-EPAVDTSRVKVFGPGIEGKDVFREATTDFTVDSRPLTQVGGDHIKAHIANPSGA 1276

Query: 1923 LEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPGLVSA 2102
              EC+VT+     Y V + P E G+++++V ++   +P SPFK+ V E   G  P  V A
Sbjct: 1277 STECFVTDNADGTYQVEYTPFEKGLHVVEVTYDDVPVPNSPFKVAVTE---GCQPSRVQA 1333

Query: 2103 YGAGLEGGVTGSPAEFIVNTSNAGAGALSVTIDGPSKVKMDCQECPEGY-RVTYTPMAPG 2279
             G GL+   T  P  F V T  AG G L +T++GPS+ K++C++  +G     Y P APG
Sbjct: 1334 QGPGLKEAFTNKPNVFTVVTRGAGIGGLGITVEGPSESKINCRDNKDGSCSAEYVPFAPG 1393

Query: 2280 SYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSVFVDSLTKTXXXXXXXXXXXX 2459
             Y ++I YGG  HI GSPF+  V          + + S V                    
Sbjct: 1394 DYDVNITYGGA-HIPGSPFRVPVK--------DVVDPSKV-------------------- 1424

Query: 2460 XXXXSKVLAKGLGLS-KAYVGQKGSFTVDCSKAGNNMLLVGVHGPRTPCEEILVKHVGSR 2636
                 K++  GLG   +A V Q  SFTVD SKAG   L V V GPR   E + V   G  
Sbjct: 1425 -----KIVGPGLGSGVRARVLQ--SFTVDSSKAGLAPLEVRVMGPRGLVEPVNVVDNGDG 1477

Query: 2637 LYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLV 2738
             ++V+Y    +G Y + VK+ DE IP SP++V V
Sbjct: 1478 THTVTYTPSQEGPYMVSVKYADEEIPRSPFKVKV 1511



 Score =  277 bits (709), Expect = 4e-74
 Identities = 238/885 (26%), Positives = 379/885 (42%), Gaps = 40/885 (4%)
 Frame = +3

Query: 204  GEITGEVRMPSGKVAQPAITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFYVD 383
            GE+   ++ P G          +DG     Y PS  G + + I +   HI  SP +  V 
Sbjct: 485  GELGVTIKGPKGLEELVKQKGFQDGVYAFEYYPSTQGKYSVSITWGGHHIQKSPFEVQVG 544

Query: 384  -YVNCGHVTAYGPGLSHGVVNKPAVFTVNTKDAGEGGLSLAIEGPSKAEISCTDNQDGTC 560
                   V A+GPGL  G+V + A F V +  +  G L  AIEGPS+A+I   D  DG+C
Sbjct: 545  PEAGMQKVRAWGPGLHGGIVGRSADFVVESIGSEVGSLGFAIEGPSQAKIEYDDQNDGSC 604

Query: 561  SVSYLPVLPGDYSILVKYNEQHIPGSPFTARV---TGD----------DSMRMSHLKVGS 701
             V Y P  PG+Y++ +  +++ I  SPF A +   +GD            +  S   V +
Sbjct: 605  DVKYWPKEPGEYAVHIMCDDEDIKDSPFMAYIHPASGDYNPDLVQAYGPGLEKSGCIVNN 664

Query: 702  AADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNG 881
             A+  ++  +   + L        G+     +K   +G    S+ P +  +H + V   G
Sbjct: 665  LAEFTVDPKDAGKAPLKIFAQDGDGQPIDIQMKSRMDGTYACSYTPVKAIKHTIAVVWGG 724

Query: 882  QHVASSPIPVVISQSEIGDASRVRVSGRGLHEG--HTFEPAEFIIDTRDAGYGGLSLSIE 1055
             ++  SP  V I Q       +V+V G G+        EP  F +D  +AG G +S+ I+
Sbjct: 725  VNIPHSPYRVSIGQG--SHPQKVKVFGPGVERSGLKAHEPTHFTVDCTEAGEGDVSVGIK 782

Query: 1056 GPSKVDINTEDLED--------GTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVT-- 1205
              ++V  + E+  D         T  V Y P   G Y I + FA Q +P SPF VKV   
Sbjct: 783  CDARVLSDEEEDVDFDIIHNANDTFTVKYVPPAAGRYTIKVLFASQEIPTSPFRVKVDPS 842

Query: 1206 -GEGRVKESITRRQRAPSVANVGSHCDLSLKIPEISIQDMTAQVTSPSGKSHEAEIVEGE 1382
                +VK       +A       +H  +  K    +  ++      P     + +I++  
Sbjct: 843  HDASKVKAEGPGLSKAGVENGKPTHFTVYTKGAGKAPLNVQFSSPGPGDAVKDLDIIDNY 902

Query: 1383 NHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLE-RAEA 1559
            ++++ +++ P + G   V V Y G  +P SP  FTVG        +++    GLE R E 
Sbjct: 903  DYSHTVKYTPTQQGNMQVLVTYGGDPIPKSP--FTVGVAAPLDLSRIKIN--GLENRVEV 958

Query: 1560 GVPAEFSIWTREAGA-GGLAIAVEGPSK----AEISFEDRKDGSCGVAYVVQEPGDYEVS 1724
            G   EF++ TR AG  G L + +  PS+      ++    ++GS    ++ +E G Y + 
Sbjct: 959  GKDQEFAVDTRGAGGQGKLDVTILSPSRKVVPCLVAPMAGREGST-AKFIPREEGLYAID 1017

Query: 1725 VKFNEEHIPDSPFVVPVASPSGDARRLTVSSLQESGLKVNQPASFAVSLNGA-KGAIDAK 1901
            + ++   +P SP+VV  + P  D  ++        G  V +PA F +   GA  G +   
Sbjct: 1018 LTYDGHPVPGSPYVVEASLPP-DPTKVKAHGPGLRGGLVGKPAEFTIDTKGAGTGGLGLT 1076

Query: 1902 VHSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGG 2081
            V  P  A  EC  ++      +V ++P + G Y +++ F   HIPGSPFK  +  P    
Sbjct: 1077 VEGPCEAKIEC--SDNGDGTCSVSYLPTKPGEYFVNILFEEVHIPGSPFKADIEMP---F 1131

Query: 2082 DPGLVSAYGAGLEGGVTGSPAEFIVNTSNAGAGALSV--TIDGPSKVKMDCQECPEG-YR 2252
            DP  V A G GLE G  G P    V+ S AG G L +    D  +K ++  +   +G Y 
Sbjct: 1132 DPSKVVASGPGLEHGKVGEPGLLSVDCSEAGPGTLGLEAVSDSGAKAEVCIENNKDGTYA 1191

Query: 2253 VTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSVFVDSLTKTXXX 2432
            VTY P+  G Y +++KYGG   +   P + +V            +TS V           
Sbjct: 1192 VTYVPLTAGMYTLTMKYGGEL-VPHFPTRVKV--------EPAVDTSRV----------- 1231

Query: 2433 XXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVD---CSKAGNNMLLVGVHGPRTPC 2603
                          KV   G+     +      FTVD    ++ G + +   +  P    
Sbjct: 1232 --------------KVFGPGIEGKDVFREATTDFTVDSRPLTQVGGDHIKAHIANPSGAS 1277

Query: 2604 EEILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLV 2738
             E  V       Y V Y   +KG + + V + D  +P SP++V V
Sbjct: 1278 TECFVTDNADGTYQVEYTPFEKGLHVVEVTYDDVPVPNSPFKVAV 1322



 Score =  252 bits (643), Expect = 2e-66
 Identities = 201/687 (29%), Positives = 308/687 (44%), Gaps = 29/687 (4%)
 Frame = +3

Query: 759  VVPPSGREEPCLLK--RLRNGHVGISFVPKETGEHLVHVKKNGQHVASSPIPVVISQSEI 932
            V  P G +E  L+     +N    + ++PK TG H V V   GQH++ SP  V + +++ 
Sbjct: 293  VEDPEGNKEEALVTPDSDKNKTYSVEYLPKVTGLHKVTVLFAGQHISKSPFEVNVDKAQ- 351

Query: 933  GDASRVRVSGRGLHEGHTF--EPAEFIIDTRDAGYGGLSLSIEGP---SKVDINTEDLED 1097
            GDAS+V   G GL        +P  F I T  AG G + + +E P   + V++  ED  +
Sbjct: 352  GDASKVTAKGPGLEVASNIANKPTYFDIYTAGAGVGDIGVEVEDPQGKNTVELLVEDRGN 411

Query: 1098 GTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTGEGRVKESITRRQRA--PSVANVG 1271
               R  Y P +PG +++ + FA   +P SPF V+V GE     +     R   P    + 
Sbjct: 412  QVYRCVYKPMQPGPHVVKVSFAGDTIPKSPFVVQV-GEACNPNACRASGRGLQPKGIRIR 470

Query: 1272 SHCDLSLKIPEISIQDMTAQVTSPSGKSHEAEIVEGENHTYCIRFVPAEMGMHTVSVKYK 1451
               D  +        ++   +  P G     +    ++  Y   + P+  G ++VS+ + 
Sbjct: 471  ETADFKVDTKAAGSGELGVTIKGPKGLEELVKQKGFQDGVYAFEYYPSTQGKYSVSITWG 530

Query: 1452 GQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLERAEAGVPAEFSIWTREAGAGGLAIAVEG 1631
            G H+  SPF+  VGP  E G  KVRA GPGL     G  A+F + +  +  G L  A+EG
Sbjct: 531  GHHIQKSPFEVQVGP--EAGMQKVRAWGPGLHGGIVGRSADFVVESIGSEVGSLGFAIEG 588

Query: 1632 PSKAEISFEDRKDGSCGVAYVVQEPGDYEVSVKFNEEHIPDSPFVVPVASPSGDARRLTV 1811
            PS+A+I ++D+ DGSC V Y  +EPG+Y V +  ++E I DSPF+  +   SGD     V
Sbjct: 589  PSQAKIEYDDQNDGSCDVKYWPKEPGEYAVHIMCDDEDIKDSPFMAYIHPASGDYNPDLV 648

Query: 1812 SS----LQESGLKVNQPASFAVSLNGA-KGAIDAKVHSPSGALEECYVTEIDQDKYAVRF 1976
             +    L++SG  VN  A F V    A K  +        G   +  +       YA  +
Sbjct: 649  QAYGPGLEKSGCIVNNLAEFTVDPKDAGKAPLKIFAQDGDGQPIDIQMKSRMDGTYACSY 708

Query: 1977 IPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPGLVSAYGAGLE--GGVTGSPAEF 2150
             P +   + I V + G +IP SP+++ +G+  H   P  V  +G G+E  G     P  F
Sbjct: 709  TPVKAIKHTIAVVWGGVNIPHSPYRVSIGQGSH---PQKVKVFGPGVERSGLKAHEPTHF 765

Query: 2151 IVNTSNAGAGALSVTIDGPSKVKMDCQE---------CPEGYRVTYTPMAPGSYLISIKY 2303
             V+ + AG G +SV I   ++V  D +E           + + V Y P A G Y I + +
Sbjct: 766  TVDCTEAGEGDVSVGIKCDARVLSDEEEDVDFDIIHNANDTFTVKYVPPAAGRYTIKVLF 825

Query: 2304 GGPYHIGGSPFKARVTGHRLVSNHSLHETSSVFVDSLTKTXXXXXXXXXXXXXXXXSKVL 2483
                 I  SPF+ +V       +H                                SKV 
Sbjct: 826  AS-QEIPTSPFRVKVD-----PSHD------------------------------ASKVK 849

Query: 2484 AKGLGLSKAYV--GQKGSFTVDCSKAGNNMLLV--GVHGPRTPCEEILVKHVGSRLYSVS 2651
            A+G GLSKA V  G+   FTV    AG   L V     GP    +++ +       ++V 
Sbjct: 850  AEGPGLSKAGVENGKPTHFTVYTKGAGKAPLNVQFSSPGPGDAVKDLDIIDNYDYSHTVK 909

Query: 2652 YLLKDKGEYTLVVKWGDEHIPGSPYRV 2732
            Y    +G   ++V +G + IP SP+ V
Sbjct: 910  YTPTQQGNMQVLVTYGGDPIPKSPFTV 936



 Score =  222 bits (566), Expect = 1e-57
 Identities = 229/840 (27%), Positives = 359/840 (42%), Gaps = 47/840 (5%)
 Frame = +3

Query: 354  PGSPLQFYVDYVNCGHVTAYGPGL--SHGVVNKPAVFTVNTKDAGEGGLSLAIEGP--SK 521
            PG+PL+     +N     AYG G+  +  +V +PA FTV+T  AG+G + + +E P  +K
Sbjct: 244  PGAPLK---PKLNPKKARAYGRGIEPTGNMVKQPAKFTVDTISAGQGDVMVFVEDPEGNK 300

Query: 522  AEISCTDNQD--GTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARVTGDDSMRMSHLKV 695
             E   T + D   T SV YLP + G + + V +  QHI  SPF   V             
Sbjct: 301  EEALVTPDSDKNKTYSVEYLPKVTGLHKVTVLFAGQHISKSPFEVNVDKAQGDASKVTAK 360

Query: 696  GSAADIPINISE--TDLSLLTA---------TVVPPSGREEPCLLKRLRNGHV-GISFVP 839
            G   ++  NI+   T   + TA          V  P G+    LL   R   V    + P
Sbjct: 361  GPGLEVASNIANKPTYFDIYTAGAGVGDIGVEVEDPQGKNTVELLVEDRGNQVYRCVYKP 420

Query: 840  KETGEHLVHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEG--HTFEPAEFIID 1013
             + G H+V V   G  +  SP   V+   E  + +  R SGRGL        E A+F +D
Sbjct: 421  MQPGPHVVKVSFAGDTIPKSPF--VVQVGEACNPNACRASGRGLQPKGIRIRETADFKVD 478

Query: 1014 TRDAGYGGLSLSIEGPSKVD--INTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSP 1187
            T+ AG G L ++I+GP  ++  +  +  +DG     Y P+  G Y ++I +   H+  SP
Sbjct: 479  TKAAGSGELGVTIKGPKGLEELVKQKGFQDGVYAFEYYPSTQGKYSVSITWGGHHIQKSP 538

Query: 1188 FSVKVTGEGRVKESITRRQRAPSVAN--VGSHCDLSLKIPEISIQDMTAQVTSPSGKSHE 1361
            F V+V  E  +++    R   P +    VG   D  ++     +  +   +  PS    E
Sbjct: 539  FEVQVGPEAGMQKV---RAWGPGLHGGIVGRSADFVVESIGSEVGSLGFAIEGPSQAKIE 595

Query: 1362 AEIVEGENHTYC-IRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPL-GEGGAHKVRAGG 1535
                + +N   C +++ P E G + V +    + +  SPF   + P  G+     V+A G
Sbjct: 596  ---YDDQNDGSCDVKYWPKEPGEYAVHIMCDDEDIKDSPFMAYIHPASGDYNPDLVQAYG 652

Query: 1536 PGLERAEAGVP--AEFSIWTREAGAGGLAI-AVEGPSK-AEISFEDRKDGSCGVAYVVQE 1703
            PGLE++   V   AEF++  ++AG   L I A +G  +  +I  + R DG+   +Y   +
Sbjct: 653  PGLEKSGCIVNNLAEFTVDPKDAGKAPLKIFAQDGDGQPIDIQMKSRMDGTYACSYTPVK 712

Query: 1704 PGDYEVSVKFNEEHIPDSPFVVPVASPSGDAR-RLTVSSLQESGLKVNQPASFAVSLNGA 1880
               + ++V +   +IP SP+ V +   S   + ++    ++ SGLK ++P  F V    A
Sbjct: 713  AIKHTIAVVWGGVNIPHSPYRVSIGQGSHPQKVKVFGPGVERSGLKAHEPTHFTVDCTEA 772

Query: 1881 -KGAI------DAKVHSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPG 2039
             +G +      DA+V S      +  +     D + V+++P   G Y I V F    IP 
Sbjct: 773  GEGDVSVGIKCDARVLSDEEEDVDFDIIHNANDTFTVKYVPPAAGRYTIKVLFASQEIPT 832

Query: 2040 SPFKIRVGEPGHGGDPGLVSAYGAGLE--GGVTGSPAEFIVNTSNAGAGALSVTID--GP 2207
            SPF+++V +P H  D   V A G GL   G   G P  F V T  AG   L+V     GP
Sbjct: 833  SPFRVKV-DPSH--DASKVKAEGPGLSKAGVENGKPTHFTVYTKGAGKAPLNVQFSSPGP 889

Query: 2208 SKVKMD---CQECPEGYRVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHS 2378
                 D          + V YTP   G+  + + YGG   I  SPF   V          
Sbjct: 890  GDAVKDLDIIDNYDYSHTVKYTPTQQGNMQVLVTYGGD-PIPKSPFTVGVAA-------- 940

Query: 2379 LHETSSVFVDSLTKTXXXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKA- 2555
                                           S++   GL  ++  VG+   F VD   A 
Sbjct: 941  ---------------------------PLDLSRIKINGLE-NRVEVGKDQEFAVDTRGAG 972

Query: 2556 GNNMLLVGVHGPRTPCEEILVKHVGSRLYSVS-YLLKDKGEYTLVVKWGDEHIPGSPYRV 2732
            G   L V +  P       LV  +  R  S + ++ +++G Y + + +    +PGSPY V
Sbjct: 973  GQGKLDVTILSPSRKVVPCLVAPMAGREGSTAKFIPREEGLYAIDLTYDGHPVPGSPYVV 1032


>ref|XP_002697039.1| PREDICTED: filamin B, beta isoform 3 [Bos taurus].
          Length = 2578

 Score = 1308 bits (3385), Expect = 0.0
 Identities = 625/872 (71%), Positives = 741/872 (84%)
 Frame = +3

Query: 126  PLVGVNGLDVTSLRPFDLVIPFTIKKGEITGEVRMPSGKVAQPAITDNKDGTVTVRYAPS 305
            P+  +NGL     +PFDLVIPF ++KGEITGEV MPSGK A+P I DNKDGTVTVRYAP+
Sbjct: 1711 PVSNMNGL---GFKPFDLVIPFAVRKGEITGEVHMPSGKTAKPEIVDNKDGTVTVRYAPT 1767

Query: 306  EAGLHEMDIRYDNMHIPGSPLQFYVDYVNCGHVTAYGPGLSHGVVNKPAVFTVNTKDAGE 485
            E GLHEM I+Y   HIP SPLQFYV+Y N G V+AYGPGL +GV NK A FT+ T+DAGE
Sbjct: 1768 EVGLHEMHIKYMGSHIPESPLQFYVNYPNSGSVSAYGPGLVYGVANKTATFTIVTEDAGE 1827

Query: 486  GGLSLAIEGPSKAEISCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARVTGD 665
            GGL LAIEGPSKAEISC DN+DGTC+V+YLP LPGDYSILVKYN++HIPGSPFTA++T D
Sbjct: 1828 GGLDLAIEGPSKAEISCIDNKDGTCTVTYLPTLPGDYSILVKYNDKHIPGSPFTAKIT-D 1886

Query: 666  DSMRMSHLKVGSAADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKE 845
            DS R S +K+GSAAD  ++ISETDLS LTA++  PSGR+EPCLLKRL N H+GISF+P+E
Sbjct: 1887 DSRRCSQVKLGSAADFLLDISETDLSTLTASIKAPSGRDEPCLLKRLPNNHIGISFIPRE 1946

Query: 846  TGEHLVHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEGHTFEPAEFIIDTRDA 1025
             GEHLV +KKNG HVA+SP+ +++ QSEIGDA R +V GRGL EG TFE ++FI+DTRDA
Sbjct: 1947 VGEHLVSIKKNGNHVANSPVSIMVVQSEIGDARRAKVYGRGLSEGRTFEMSDFIVDTRDA 2006

Query: 1026 GYGGLSLSIEGPSKVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVT 1205
            GYGG+SL++EGPSKVDI TEDLEDGTC+V+Y PT PG YI++ KFAD+HVPGSPF+VK++
Sbjct: 2007 GYGGISLAVEGPSKVDIQTEDLEDGTCKVSYFPTVPGVYIVSTKFADEHVPGSPFTVKIS 2066

Query: 1206 GEGRVKESITRRQRAPSVANVGSHCDLSLKIPEISIQDMTAQVTSPSGKSHEAEIVEGEN 1385
            GEGRVKESITR  RAPSVA VGS CDL+LKIPEI   DM+A VTSPSG+  EAEIV    
Sbjct: 2067 GEGRVKESITRTSRAPSVATVGSICDLNLKIPEIDSSDMSAHVTSPSGRVTEAEIVPVGK 2126

Query: 1386 HTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLERAEAGV 1565
            +++C+RFVP EMG+HTVSVKY+GQHV GSPFQFTVGPLGEGGAHKVRAGGPGLER EAGV
Sbjct: 2127 NSHCVRFVPQEMGVHTVSVKYRGQHVTGSPFQFTVGPLGEGGAHKVRAGGPGLERGEAGV 2186

Query: 1566 PAEFSIWTREAGAGGLAIAVEGPSKAEISFEDRKDGSCGVAYVVQEPGDYEVSVKFNEEH 1745
            PAEFSIWTREAGAGGL+IAVEGPSKAEI+F+D K+GSCGV+Y+ QEPG+YEVS+KFN+EH
Sbjct: 2187 PAEFSIWTREAGAGGLSIAVEGPSKAEITFDDHKNGSCGVSYIAQEPGNYEVSIKFNDEH 2246

Query: 1746 IPDSPFVVPVASPSGDARRLTVSSLQESGLKVNQPASFAVSLNGAKGAIDAKVHSPSGAL 1925
            IP+SP+VVPV +PS DARRLTV SLQESGLKVNQPASFA+ LNGAKG IDAKVHSPSGA+
Sbjct: 2247 IPESPYVVPVIAPSDDARRLTVLSLQESGLKVNQPASFAIRLNGAKGKIDAKVHSPSGAV 2306

Query: 1926 EECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPGLVSAY 2105
            EEC+V+E++ DKYAVRFIP ENG++ IDVKFNG+H+ GSPFK+RVGEPG  G+P LVSAY
Sbjct: 2307 EECHVSELEPDKYAVRFIPHENGIHTIDVKFNGSHVVGSPFKVRVGEPGQAGNPALVSAY 2366

Query: 2106 GAGLEGGVTGSPAEFIVNTSNAGAGALSVTIDGPSKVKMDCQECPEGYRVTYTPMAPGSY 2285
            GAGLEGG TG  +EF +NT+ AG G LSVTI+GPSKVKMDCQE PEGY+V YTPMAPG+Y
Sbjct: 2367 GAGLEGGSTGIQSEFFINTTRAGPGTLSVTIEGPSKVKMDCQETPEGYKVMYTPMAPGNY 2426

Query: 2286 LISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSVFVDSLTKTXXXXXXXXXXXXXX 2465
            LI +KYGGP HI GSPFKA+VTG RLVS  S +ETSS+ V+S+T++              
Sbjct: 2427 LIGVKYGGPNHIVGSPFKAKVTGQRLVSPGSANETSSILVESVTRSSTETCYSAIPKASS 2486

Query: 2466 XXSKVLAKGLGLSKAYVGQKGSFTVDCSKAGNNMLLVGVHGPRTPCEEILVKHVGSRLYS 2645
              SKV +KG GLSKA++GQK SF VDCSKAG+NMLL+GVHGP TPCEE+ +KHVG++ Y+
Sbjct: 2487 DASKVTSKGAGLSKAFLGQKSSFLVDCSKAGSNMLLIGVHGPTTPCEEVSMKHVGNQQYN 2546

Query: 2646 VSYLLKDKGEYTLVVKWGDEHIPGSPYRVLVP 2741
            V+Y++K++G+Y L VKWG+EHIPGSP+ V VP
Sbjct: 2547 VTYVVKERGDYVLAVKWGEEHIPGSPFHVTVP 2578



 Score =  434 bits (1115), Expect = e-121
 Identities = 287/872 (32%), Positives = 424/872 (48%), Gaps = 15/872 (1%)
 Frame = +3

Query: 168  PFDLVIPFTIK-----KGEITGEVRMPSGKVAQPAITDNKDGTVTVRYAPSEAGLHEMDI 332
            P  L + F I      +G +  ++    GK  +  + DNKDGT  V Y P + G + + +
Sbjct: 1533 PASLPVEFAIDARDAGEGLLAVQITDQEGKPKRAIVHDNKDGTYAVTYIPDKTGRYMIGV 1592

Query: 333  RYDNMHIPGSPLQFYVDYV-NCGHVTAYGPGLSHGVVNKPAV-FTVNTKDAGEGGLSLAI 506
             Y    IP SP +       +     A GPG++  V     V F V+ K AG+G ++  +
Sbjct: 1593 TYGGDDIPLSPYRIRATQTGDASKCLATGPGIASTVKTGEEVGFVVDAKTAGKGKVTCTV 1652

Query: 507  EGP--SKAEISCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARVTGDDSMRM 680
              P  ++AE    +N+DGT  + Y    PG Y I V++    IP SPFT  VT +  + +
Sbjct: 1653 LTPDGTEAEADVIENEDGTYDIFYTAAKPGTYVIYVRFGGVDIPNSPFTVMVTEEAYVPV 1712

Query: 681  SHLK-VGSA---ADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKET 848
            S++  +G       IP  + + +   +T  V  PSG+     +   ++G V + + P E 
Sbjct: 1713 SNMNGLGFKPFDLVIPFAVRKGE---ITGEVHMPSGKTAKPEIVDNKDGTVTVRYAPTEV 1769

Query: 849  GEHLVHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEGHTFEPAEFIIDTRDAG 1028
            G H +H+K  G H+  SP+   ++    G  S     G GL  G   + A F I T DAG
Sbjct: 1770 GLHEMHIKYMGSHIPESPLQFYVNYPNSGSVS---AYGPGLVYGVANKTATFTIVTEDAG 1826

Query: 1029 YGGLSLSIEGPSKVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTG 1208
             GGL L+IEGPSK +I+  D +DGTC VTY PT PG+Y I +K+ D+H+PGSPF+ K+T 
Sbjct: 1827 EGGLDLAIEGPSKAEISCIDNKDGTCTVTYLPTLPGDYSILVKYNDKHIPGSPFTAKITD 1886

Query: 1209 EGRVKESITRRQRAPSVANVGSHCDLSLKIPEISIQDMTAQVTSPSGKSHEAEIVEGENH 1388
            +           R  S   +GS  D  L I E  +  +TA + +PSG+     +    N+
Sbjct: 1887 D----------SRRCSQVKLGSAADFLLDISETDLSTLTASIKAPSGRDEPCLLKRLPNN 1936

Query: 1389 TYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLERAEAGVP 1568
               I F+P E+G H VS+K  G HV  SP    V     G A + +  G GL        
Sbjct: 1937 HIGISFIPREVGEHLVSIKKNGNHVANSPVSIMVVQSEIGDARRAKVYGRGLSEGRTFEM 1996

Query: 1569 AEFSIWTREAGAGGLAIAVEGPSKAEISFEDRKDGSCGVAYVVQEPGDYEVSVKFNEEHI 1748
            ++F + TR+AG GG+++AVEGPSK +I  ED +DG+C V+Y    PG Y VS KF +EH+
Sbjct: 1997 SDFIVDTRDAGYGGISLAVEGPSKVDIQTEDLEDGTCKVSYFPTVPGVYIVSTKFADEHV 2056

Query: 1749 PDSPFVVPVASPSGDARRLTVSSLQESGLKVNQPASFAVSLNGAKGA-IDAKVHSPSGAL 1925
            P SPF V ++        +T +S   S   V       + +     + + A V SPSG +
Sbjct: 2057 PGSPFTVKISGEGRVKESITRTSRAPSVATVGSICDLNLKIPEIDSSDMSAHVTSPSGRV 2116

Query: 1926 EECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPGLVSAY 2105
             E  +  + ++ + VRF+P+E GV+ + VK+ G H+ GSPF+  VG  G GG    V A 
Sbjct: 2117 TEAEIVPVGKNSHCVRFVPQEMGVHTVSVKYRGQHVTGSPFQFTVGPLGEGG-AHKVRAG 2175

Query: 2106 GAGLEGGVTGSPAEFIVNTSNAGAGALSVTIDGPSKVKMDCQECPEG-YRVTYTPMAPGS 2282
            G GLE G  G PAEF + T  AGAG LS+ ++GPSK ++   +   G   V+Y    PG+
Sbjct: 2176 GPGLERGEAGVPAEFSIWTREAGAGGLSIAVEGPSKAEITFDDHKNGSCGVSYIAQEPGN 2235

Query: 2283 YLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSVFVDSLTKTXXXXXXXXXXXXX 2462
            Y +SIK+    HI  SP+   V                                      
Sbjct: 2236 YEVSIKFNDE-HIPESPYVVPVIA----------------------------------PS 2260

Query: 2463 XXXSKVLAKGLGLSKAYVGQKGSFTVDCSKAGNNMLLVGVHGPRTPCEEILVKHVGSRLY 2642
                ++    L  S   V Q  SF +  + A    +   VH P    EE  V  +    Y
Sbjct: 2261 DDARRLTVLSLQESGLKVNQPASFAIRLNGA-KGKIDAKVHSPSGAVEECHVSELEPDKY 2319

Query: 2643 SVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLV 2738
            +V ++  + G +T+ VK+   H+ GSP++V V
Sbjct: 2320 AVRFIPHENGIHTIDVKFNGSHVVGSPFKVRV 2351



 Score =  332 bits (852), Expect = 9e-91
 Identities = 243/756 (32%), Positives = 368/756 (48%), Gaps = 39/756 (5%)
 Frame = +3

Query: 201  KGEITGEVRMPSGKVAQPAITD--NKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQF 374
            +G++   +  PS KV    +     ++G+ T ++ P E GL+ +D+ YD   +PGSP   
Sbjct: 974  QGKLDVTILSPSRKVVPCLVAPMAGREGS-TAKFIPREEGLYAIDLTYDGHPVPGSPYVV 1032

Query: 375  YVDYV-NCGHVTAYGPGLSHGVVNKPAVFTVNTKDAGEGGLSLAIEGPSKAEISCTDNQD 551
                  +   V A+GPGL  G+V KPA FT++TK AG GGL L +EGP +A+I C+DN D
Sbjct: 1033 EASLPPDPTKVKAHGPGLRGGLVGKPAEFTIDTKGAGTGGLGLTVEGPCEAKIECSDNGD 1092

Query: 552  GTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARV--------TGDDSMRMSHLKVGSAA 707
            GTCSVSYLP  PG+Y + + + E HIPGSPF A +               + H KVG   
Sbjct: 1093 GTCSVSYLPTKPGEYFVNILFEEVHIPGSPFKADIEMPFDPSKVVASGPGLEHGKVGEPG 1152

Query: 708  DIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNGQH 887
             + ++ SE     L    V  SG +    ++  ++G   +++VP   G + + +K  G+ 
Sbjct: 1153 LLSVDCSEAGPGTLGLEAVSDSGAKAEVCIENNKDGTYAVTYVPLTAGMYTLTMKYGGEL 1212

Query: 888  VASSPIPVVISQSEIGDASRVRVSGRGLHEGHTFEPA--EFIIDTR---DAGYGGLSLSI 1052
            V   P  V +  +   D SRV+V G G+     F  A  +F +D+R     G   +   I
Sbjct: 1213 VPHFPTRVKVEPAV--DTSRVKVFGPGIEGKDVFREATTDFTVDSRPLTQVGGDHIKAHI 1270

Query: 1053 EGPS--KVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVT------- 1205
              PS    +    D  DGT +V Y P E G +++ + + D  VP SPF V VT       
Sbjct: 1271 ANPSGASTECFVTDNADGTYQVEYTPFEKGLHVVEVTYDDVPVPNSPFKVAVTEGCQPSR 1330

Query: 1206 ----GEGRVKESITRRQRAPSVANVGSHCDLSLKIPEISIQDMTAQVTSPSGKSHEAEIV 1373
                G G +KE+ T +    +V   G+            I  +   V  PS    +    
Sbjct: 1331 VQAQGPG-LKEAFTNKPNVFTVVTRGA-----------GIGGLGITVEGPS--ESKINCR 1376

Query: 1374 EGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGL-ER 1550
            + ++ +    +VP   G + V++ Y G H+PGSPF+  V  + +    KV+  GPGL   
Sbjct: 1377 DNKDGSCSAEYVPFAPGDYDVNITYGGAHIPGSPFRVPVKDVVD--PSKVKIVGPGLGSG 1434

Query: 1551 AEAGVPAEFSIWTREAGAGGLAIAVEGPS--KAEISFEDRKDGSCGVAYVVQEPGDYEVS 1724
              A V   F++ + +AG   L + V GP      ++  D  DG+  V Y   + G Y VS
Sbjct: 1435 VRARVLQSFTVDSSKAGLAPLEVRVMGPRGLVEPVNVVDNGDGTHTVTYTPSQEGPYMVS 1494

Query: 1725 VKFNEEHIPDSPFVVPVASPSGDARRLTVS--SLQESGLKVNQPASFAVSLNGA-KGAID 1895
            VK+ +E IP SPF V V  P+ DA ++T S   L   G+  + P  FA+    A +G + 
Sbjct: 1495 VKYADEEIPRSPFKVKVL-PTYDASKVTASGPGLSTYGVPASLPVEFAIDARDAGEGLLA 1553

Query: 1896 AKVHSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGH 2075
             ++    G  +   V +     YAV +IP + G Y+I V + G  IP SP++IR  +   
Sbjct: 1554 VQITDQEGKPKRAIVHDNKDGTYAVTYIPDKTGRYMIGVTYGGDDIPLSPYRIRATQT-- 1611

Query: 2076 GGDPGLVSAYGAGLEGGV-TGSPAEFIVNTSNAGAGALSVTIDGP--SKVKMDCQECPEG 2246
             GD     A G G+   V TG    F+V+   AG G ++ T+  P  ++ + D  E  +G
Sbjct: 1612 -GDASKCLATGPGIASTVKTGEEVGFVVDAKTAGKGKVTCTVLTPDGTEAEADVIENEDG 1670

Query: 2247 -YRVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVT 2351
             Y + YT   PG+Y+I +++GG   I  SPF   VT
Sbjct: 1671 TYDIFYTAAKPGTYVIYVRFGG-VDIPNSPFTVMVT 1705



 Score =  296 bits (758), Expect = 7e-80
 Identities = 240/890 (26%), Positives = 386/890 (43%), Gaps = 47/890 (5%)
 Frame = +3

Query: 201  KGEITGEVRMPSGKVAQPAIT--DNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQF 374
            +G++   V  P G   +  +T   +K+ T +V Y P   GLH++ + +   HI  SP + 
Sbjct: 286  QGDVMVFVEDPEGNKEEALVTPDSDKNKTYSVEYLPKVTGLHKVTVLFAGQHISKSPFEV 345

Query: 375  YVDYV--NCGHVTAYGPGL--SHGVVNKPAVFTVNTKDAGEGGLSLAIEGP---SKAEIS 533
             VD    +   VTA GPGL  +  + NKP  F + T  AG G + + +E P   +  E+ 
Sbjct: 346  NVDKAQGDASKVTAKGPGLEVASNIANKPTYFDIYTAGAGVGDIGVEVEDPQGKNTVELL 405

Query: 534  CTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARV----------TGDDSMRMS 683
              D  +      Y P+ PG + + V +    IP SPF  +V               ++  
Sbjct: 406  VEDRGNQVYRCVYKPMQPGPHVVKVSFAGDTIPKSPFVVQVGEACNPNACRASGRGLQPK 465

Query: 684  HLKVGSAADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLV 863
             +++   AD  ++        L  T+  P G EE    K  ++G     + P   G++ V
Sbjct: 466  GIRIRETADFKVDTKAAGSGELGVTIKGPKGLEELVKQKGFQDGVYAFEYYPSTQGKYSV 525

Query: 864  HVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEGHTFEPAEFIIDTRDAGYGGLS 1043
             +   G H+  SP  V +         +VR  G GLH G     A+F++++  +  G L 
Sbjct: 526  SITWGGHHIQKSPFEVQVGPE--AGMQKVRAWGPGLHGGIVGRSADFVVESIGSEVGSLG 583

Query: 1044 LSIEGPSKVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKV-TGEGRV 1220
             +IEGPS+  I  +D  DG+C V Y P EPG Y ++I   D+ +  SPF   +    G  
Sbjct: 584  FAIEGPSQAKIEYDDQNDGSCDVKYWPKEPGEYAVHIMCDDEDIKDSPFMAYIHPASGDY 643

Query: 1221 KESITRRQ---RAPSVANVGSHCDLSLKIPEISIQDMTAQVTSPSGKSHEAEIVEGENHT 1391
               + +        S   V +  + ++   +     +        G+  + ++    + T
Sbjct: 644  NPDLVQAYGPGLEKSGCIVNNLAEFTVDPKDAGKAPLKIFAQDGDGQPIDIQMKSRMDGT 703

Query: 1392 YCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAH--KVRAGGPGLERA--EA 1559
            Y   + P +   HT++V + G ++P SP++ ++G     G+H  KV+  GPG+ER+  +A
Sbjct: 704  YACSYTPVKAIKHTIAVVWGGVNIPHSPYRVSIGQ----GSHPQKVKVFGPGVERSGLKA 759

Query: 1560 GVPAEFSIWTREAGAGGLAIAVE------GPSKAEISFE--DRKDGSCGVAYVVQEPGDY 1715
              P  F++   EAG G +++ ++         + ++ F+     + +  V YV    G Y
Sbjct: 760  HEPTHFTVDCTEAGEGDVSVGIKCDARVLSDEEEDVDFDIIHNANDTFTVKYVPPAAGRY 819

Query: 1716 EVSVKFNEEHIPDSPFVVPVASPSGDARRLTVS--SLQESGLKVNQPASFAVSLNGA-KG 1886
             + V F  + IP SPF V V  PS DA ++      L ++G++  +P  F V   GA K 
Sbjct: 820  TIKVLFASQEIPTSPFRVKV-DPSHDASKVKAEGPGLSKAGVENGKPTHFTVYTKGAGKA 878

Query: 1887 AIDAKVHS--PSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRV 2060
             ++ +  S  P  A+++  + +     + V++ P + G   + V + G  IP SPF + V
Sbjct: 879  PLNVQFSSPGPGDAVKDLDIIDNYDYSHTVKYTPTQQGNMQVLVTYGGDPIPKSPFTVGV 938

Query: 2061 GEPGHGGDPGLVSAYGAGLEGGV-TGSPAEFIVNTSNAGA-GALSVTIDGPSKVKMDCQE 2234
              P       L      GLE  V  G   EF V+T  AG  G L VTI  PS+  + C  
Sbjct: 939  AAP-----LDLSRIKINGLENRVEVGKDQEFAVDTRGAGGQGKLDVTILSPSRKVVPCLV 993

Query: 2235 CP----EGYRVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSVF 2402
             P    EG    + P   G Y I + Y G + + GSP+    +                 
Sbjct: 994  APMAGREGSTAKFIPREEGLYAIDLTYDG-HPVPGSPYVVEAS----------------- 1035

Query: 2403 VDSLTKTXXXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKAGNNMLLVGV 2582
                                   +KV A G GL    VG+   FT+D   AG   L + V
Sbjct: 1036 ------------------LPPDPTKVKAHGPGLRGGLVGKPAEFTIDTKGAGTGGLGLTV 1077

Query: 2583 HGPRTPCE-EILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYR 2729
             G   PCE +I     G    SVSYL    GEY + + + + HIPGSP++
Sbjct: 1078 EG---PCEAKIECSDNGDGTCSVSYLPTKPGEYFVNILFEEVHIPGSPFK 1124



 Score =  293 bits (751), Expect = 5e-79
 Identities = 253/874 (28%), Positives = 399/874 (45%), Gaps = 52/874 (5%)
 Frame = +3

Query: 273  DGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFYVDYVNCGH-VTAYGPGLSHGVV--N 443
            DGT    Y P +A  H + + +  ++IP SP +  +   +    V  +GPG+    +  +
Sbjct: 701  DGTYACSYTPVKAIKHTIAVVWGGVNIPHSPYRVSIGQGSHPQKVKVFGPGVERSGLKAH 760

Query: 444  KPAVFTVNTKDAGEGGLSLAIEGPSKA--------EISCTDNQDGTCSVSYLPVLPGDYS 599
            +P  FTV+  +AGEG +S+ I+  ++         +     N + T +V Y+P   G Y+
Sbjct: 761  EPTHFTVDCTEAGEGDVSVGIKCDARVLSDEEEDVDFDIIHNANDTFTVKYVPPAAGRYT 820

Query: 600  ILVKYNEQHIPGSPFTARV------------------TGDDSMRMSHLKVGS--AADIPI 719
            I V +  Q IP SPF  +V                   G ++ + +H  V +  A   P+
Sbjct: 821  IKVLFASQEIPTSPFRVKVDPSHDASKVKAEGPGLSKAGVENGKPTHFTVYTKGAGKAPL 880

Query: 720  NISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNGQHVASS 899
            N+  +          P    ++  ++      H  + + P + G   V V   G  +  S
Sbjct: 881  NVQFSSPG-------PGDAVKDLDIIDNYDYSHT-VKYTPTQQGNMQVLVTYGGDPIPKS 932

Query: 900  PIPVVISQSEIGDASRVRVSGRGLHEGHTFEPAEFIIDTRDAG-YGGLSLSIEGPSKVDI 1076
            P  V ++     D SR++++G   +     +  EF +DTR AG  G L ++I  PS+  +
Sbjct: 933  PFTVGVAAPL--DLSRIKINGLE-NRVEVGKDQEFAVDTRGAGGQGKLDVTILSPSRKVV 989

Query: 1077 NT-----EDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTGEGRVKESITR- 1238
                      E  T +  + P E G Y I++ +    VPGSP+ V    E  +    T+ 
Sbjct: 990  PCLVAPMAGREGSTAK--FIPREEGLYAIDLTYDGHPVPGSPYVV----EASLPPDPTKV 1043

Query: 1239 RQRAPSVAN--VGSHCDLSLKIPEISIQDMTAQVTSPSGKSHEAEIVEGENH--TYCIRF 1406
            +   P +    VG   + ++         +   V  P     EA+I   +N   T  + +
Sbjct: 1044 KAHGPGLRGGLVGKPAEFTIDTKGAGTGGLGLTVEGPC----EAKIECSDNGDGTCSVSY 1099

Query: 1407 VPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLERAEAGVPAEFSIW 1586
            +P + G + V++ ++  H+PGSPF+  +    +    KV A GPGLE  + G P   S+ 
Sbjct: 1100 LPTKPGEYFVNILFEEVHIPGSPFKADIEMPFDPS--KVVASGPGLEHGKVGEPGLLSVD 1157

Query: 1587 TREAGAG--GLAIAVEGPSKAEISFEDRKDGSCGVAYVVQEPGDYEVSVKFNEEHIPDSP 1760
              EAG G  GL    +  +KAE+  E+ KDG+  V YV    G Y +++K+  E +P  P
Sbjct: 1158 CSEAGPGTLGLEAVSDSGAKAEVCIENNKDGTYAVTYVPLTAGMYTLTMKYGGELVPHFP 1217

Query: 1761 FVVPVASPSGDARRLTVSSLQESGLKVNQPASFAVSLNGAK------GAIDAKVHSPSGA 1922
              V V  P+ D  R+ V      G  V + A+   +++           I A + +PSGA
Sbjct: 1218 TRVKV-EPAVDTSRVKVFGPGIEGKDVFREATTDFTVDSRPLTQVGGDHIKAHIANPSGA 1276

Query: 1923 LEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPGLVSA 2102
              EC+VT+     Y V + P E G+++++V ++   +P SPFK+ V E   G  P  V A
Sbjct: 1277 STECFVTDNADGTYQVEYTPFEKGLHVVEVTYDDVPVPNSPFKVAVTE---GCQPSRVQA 1333

Query: 2103 YGAGLEGGVTGSPAEFIVNTSNAGAGALSVTIDGPSKVKMDCQECPEGY-RVTYTPMAPG 2279
             G GL+   T  P  F V T  AG G L +T++GPS+ K++C++  +G     Y P APG
Sbjct: 1334 QGPGLKEAFTNKPNVFTVVTRGAGIGGLGITVEGPSESKINCRDNKDGSCSAEYVPFAPG 1393

Query: 2280 SYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSVFVDSLTKTXXXXXXXXXXXX 2459
             Y ++I YGG  HI GSPF+  V          + + S V                    
Sbjct: 1394 DYDVNITYGGA-HIPGSPFRVPVK--------DVVDPSKV-------------------- 1424

Query: 2460 XXXXSKVLAKGLGLS-KAYVGQKGSFTVDCSKAGNNMLLVGVHGPRTPCEEILVKHVGSR 2636
                 K++  GLG   +A V Q  SFTVD SKAG   L V V GPR   E + V   G  
Sbjct: 1425 -----KIVGPGLGSGVRARVLQ--SFTVDSSKAGLAPLEVRVMGPRGLVEPVNVVDNGDG 1477

Query: 2637 LYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLV 2738
             ++V+Y    +G Y + VK+ DE IP SP++V V
Sbjct: 1478 THTVTYTPSQEGPYMVSVKYADEEIPRSPFKVKV 1511



 Score =  277 bits (709), Expect = 4e-74
 Identities = 238/885 (26%), Positives = 379/885 (42%), Gaps = 40/885 (4%)
 Frame = +3

Query: 204  GEITGEVRMPSGKVAQPAITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFYVD 383
            GE+   ++ P G          +DG     Y PS  G + + I +   HI  SP +  V 
Sbjct: 485  GELGVTIKGPKGLEELVKQKGFQDGVYAFEYYPSTQGKYSVSITWGGHHIQKSPFEVQVG 544

Query: 384  -YVNCGHVTAYGPGLSHGVVNKPAVFTVNTKDAGEGGLSLAIEGPSKAEISCTDNQDGTC 560
                   V A+GPGL  G+V + A F V +  +  G L  AIEGPS+A+I   D  DG+C
Sbjct: 545  PEAGMQKVRAWGPGLHGGIVGRSADFVVESIGSEVGSLGFAIEGPSQAKIEYDDQNDGSC 604

Query: 561  SVSYLPVLPGDYSILVKYNEQHIPGSPFTARV---TGD----------DSMRMSHLKVGS 701
             V Y P  PG+Y++ +  +++ I  SPF A +   +GD            +  S   V +
Sbjct: 605  DVKYWPKEPGEYAVHIMCDDEDIKDSPFMAYIHPASGDYNPDLVQAYGPGLEKSGCIVNN 664

Query: 702  AADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNG 881
             A+  ++  +   + L        G+     +K   +G    S+ P +  +H + V   G
Sbjct: 665  LAEFTVDPKDAGKAPLKIFAQDGDGQPIDIQMKSRMDGTYACSYTPVKAIKHTIAVVWGG 724

Query: 882  QHVASSPIPVVISQSEIGDASRVRVSGRGLHEG--HTFEPAEFIIDTRDAGYGGLSLSIE 1055
             ++  SP  V I Q       +V+V G G+        EP  F +D  +AG G +S+ I+
Sbjct: 725  VNIPHSPYRVSIGQG--SHPQKVKVFGPGVERSGLKAHEPTHFTVDCTEAGEGDVSVGIK 782

Query: 1056 GPSKVDINTEDLED--------GTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVT-- 1205
              ++V  + E+  D         T  V Y P   G Y I + FA Q +P SPF VKV   
Sbjct: 783  CDARVLSDEEEDVDFDIIHNANDTFTVKYVPPAAGRYTIKVLFASQEIPTSPFRVKVDPS 842

Query: 1206 -GEGRVKESITRRQRAPSVANVGSHCDLSLKIPEISIQDMTAQVTSPSGKSHEAEIVEGE 1382
                +VK       +A       +H  +  K    +  ++      P     + +I++  
Sbjct: 843  HDASKVKAEGPGLSKAGVENGKPTHFTVYTKGAGKAPLNVQFSSPGPGDAVKDLDIIDNY 902

Query: 1383 NHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLE-RAEA 1559
            ++++ +++ P + G   V V Y G  +P SP  FTVG        +++    GLE R E 
Sbjct: 903  DYSHTVKYTPTQQGNMQVLVTYGGDPIPKSP--FTVGVAAPLDLSRIKIN--GLENRVEV 958

Query: 1560 GVPAEFSIWTREAGA-GGLAIAVEGPSK----AEISFEDRKDGSCGVAYVVQEPGDYEVS 1724
            G   EF++ TR AG  G L + +  PS+      ++    ++GS    ++ +E G Y + 
Sbjct: 959  GKDQEFAVDTRGAGGQGKLDVTILSPSRKVVPCLVAPMAGREGST-AKFIPREEGLYAID 1017

Query: 1725 VKFNEEHIPDSPFVVPVASPSGDARRLTVSSLQESGLKVNQPASFAVSLNGA-KGAIDAK 1901
            + ++   +P SP+VV  + P  D  ++        G  V +PA F +   GA  G +   
Sbjct: 1018 LTYDGHPVPGSPYVVEASLPP-DPTKVKAHGPGLRGGLVGKPAEFTIDTKGAGTGGLGLT 1076

Query: 1902 VHSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGG 2081
            V  P  A  EC  ++      +V ++P + G Y +++ F   HIPGSPFK  +  P    
Sbjct: 1077 VEGPCEAKIEC--SDNGDGTCSVSYLPTKPGEYFVNILFEEVHIPGSPFKADIEMP---F 1131

Query: 2082 DPGLVSAYGAGLEGGVTGSPAEFIVNTSNAGAGALSV--TIDGPSKVKMDCQECPEG-YR 2252
            DP  V A G GLE G  G P    V+ S AG G L +    D  +K ++  +   +G Y 
Sbjct: 1132 DPSKVVASGPGLEHGKVGEPGLLSVDCSEAGPGTLGLEAVSDSGAKAEVCIENNKDGTYA 1191

Query: 2253 VTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSVFVDSLTKTXXX 2432
            VTY P+  G Y +++KYGG   +   P + +V            +TS V           
Sbjct: 1192 VTYVPLTAGMYTLTMKYGGEL-VPHFPTRVKV--------EPAVDTSRV----------- 1231

Query: 2433 XXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVD---CSKAGNNMLLVGVHGPRTPC 2603
                          KV   G+     +      FTVD    ++ G + +   +  P    
Sbjct: 1232 --------------KVFGPGIEGKDVFREATTDFTVDSRPLTQVGGDHIKAHIANPSGAS 1277

Query: 2604 EEILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLV 2738
             E  V       Y V Y   +KG + + V + D  +P SP++V V
Sbjct: 1278 TECFVTDNADGTYQVEYTPFEKGLHVVEVTYDDVPVPNSPFKVAV 1322



 Score =  252 bits (643), Expect = 2e-66
 Identities = 201/687 (29%), Positives = 308/687 (44%), Gaps = 29/687 (4%)
 Frame = +3

Query: 759  VVPPSGREEPCLLK--RLRNGHVGISFVPKETGEHLVHVKKNGQHVASSPIPVVISQSEI 932
            V  P G +E  L+     +N    + ++PK TG H V V   GQH++ SP  V + +++ 
Sbjct: 293  VEDPEGNKEEALVTPDSDKNKTYSVEYLPKVTGLHKVTVLFAGQHISKSPFEVNVDKAQ- 351

Query: 933  GDASRVRVSGRGLHEGHTF--EPAEFIIDTRDAGYGGLSLSIEGP---SKVDINTEDLED 1097
            GDAS+V   G GL        +P  F I T  AG G + + +E P   + V++  ED  +
Sbjct: 352  GDASKVTAKGPGLEVASNIANKPTYFDIYTAGAGVGDIGVEVEDPQGKNTVELLVEDRGN 411

Query: 1098 GTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTGEGRVKESITRRQRA--PSVANVG 1271
               R  Y P +PG +++ + FA   +P SPF V+V GE     +     R   P    + 
Sbjct: 412  QVYRCVYKPMQPGPHVVKVSFAGDTIPKSPFVVQV-GEACNPNACRASGRGLQPKGIRIR 470

Query: 1272 SHCDLSLKIPEISIQDMTAQVTSPSGKSHEAEIVEGENHTYCIRFVPAEMGMHTVSVKYK 1451
               D  +        ++   +  P G     +    ++  Y   + P+  G ++VS+ + 
Sbjct: 471  ETADFKVDTKAAGSGELGVTIKGPKGLEELVKQKGFQDGVYAFEYYPSTQGKYSVSITWG 530

Query: 1452 GQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLERAEAGVPAEFSIWTREAGAGGLAIAVEG 1631
            G H+  SPF+  VGP  E G  KVRA GPGL     G  A+F + +  +  G L  A+EG
Sbjct: 531  GHHIQKSPFEVQVGP--EAGMQKVRAWGPGLHGGIVGRSADFVVESIGSEVGSLGFAIEG 588

Query: 1632 PSKAEISFEDRKDGSCGVAYVVQEPGDYEVSVKFNEEHIPDSPFVVPVASPSGDARRLTV 1811
            PS+A+I ++D+ DGSC V Y  +EPG+Y V +  ++E I DSPF+  +   SGD     V
Sbjct: 589  PSQAKIEYDDQNDGSCDVKYWPKEPGEYAVHIMCDDEDIKDSPFMAYIHPASGDYNPDLV 648

Query: 1812 SS----LQESGLKVNQPASFAVSLNGA-KGAIDAKVHSPSGALEECYVTEIDQDKYAVRF 1976
             +    L++SG  VN  A F V    A K  +        G   +  +       YA  +
Sbjct: 649  QAYGPGLEKSGCIVNNLAEFTVDPKDAGKAPLKIFAQDGDGQPIDIQMKSRMDGTYACSY 708

Query: 1977 IPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPGLVSAYGAGLE--GGVTGSPAEF 2150
             P +   + I V + G +IP SP+++ +G+  H   P  V  +G G+E  G     P  F
Sbjct: 709  TPVKAIKHTIAVVWGGVNIPHSPYRVSIGQGSH---PQKVKVFGPGVERSGLKAHEPTHF 765

Query: 2151 IVNTSNAGAGALSVTIDGPSKVKMDCQE---------CPEGYRVTYTPMAPGSYLISIKY 2303
             V+ + AG G +SV I   ++V  D +E           + + V Y P A G Y I + +
Sbjct: 766  TVDCTEAGEGDVSVGIKCDARVLSDEEEDVDFDIIHNANDTFTVKYVPPAAGRYTIKVLF 825

Query: 2304 GGPYHIGGSPFKARVTGHRLVSNHSLHETSSVFVDSLTKTXXXXXXXXXXXXXXXXSKVL 2483
                 I  SPF+ +V       +H                                SKV 
Sbjct: 826  AS-QEIPTSPFRVKVD-----PSHD------------------------------ASKVK 849

Query: 2484 AKGLGLSKAYV--GQKGSFTVDCSKAGNNMLLV--GVHGPRTPCEEILVKHVGSRLYSVS 2651
            A+G GLSKA V  G+   FTV    AG   L V     GP    +++ +       ++V 
Sbjct: 850  AEGPGLSKAGVENGKPTHFTVYTKGAGKAPLNVQFSSPGPGDAVKDLDIIDNYDYSHTVK 909

Query: 2652 YLLKDKGEYTLVVKWGDEHIPGSPYRV 2732
            Y    +G   ++V +G + IP SP+ V
Sbjct: 910  YTPTQQGNMQVLVTYGGDPIPKSPFTV 936



 Score =  222 bits (566), Expect = 1e-57
 Identities = 229/840 (27%), Positives = 359/840 (42%), Gaps = 47/840 (5%)
 Frame = +3

Query: 354  PGSPLQFYVDYVNCGHVTAYGPGL--SHGVVNKPAVFTVNTKDAGEGGLSLAIEGP--SK 521
            PG+PL+     +N     AYG G+  +  +V +PA FTV+T  AG+G + + +E P  +K
Sbjct: 244  PGAPLK---PKLNPKKARAYGRGIEPTGNMVKQPAKFTVDTISAGQGDVMVFVEDPEGNK 300

Query: 522  AEISCTDNQD--GTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARVTGDDSMRMSHLKV 695
             E   T + D   T SV YLP + G + + V +  QHI  SPF   V             
Sbjct: 301  EEALVTPDSDKNKTYSVEYLPKVTGLHKVTVLFAGQHISKSPFEVNVDKAQGDASKVTAK 360

Query: 696  GSAADIPINISE--TDLSLLTA---------TVVPPSGREEPCLLKRLRNGHV-GISFVP 839
            G   ++  NI+   T   + TA          V  P G+    LL   R   V    + P
Sbjct: 361  GPGLEVASNIANKPTYFDIYTAGAGVGDIGVEVEDPQGKNTVELLVEDRGNQVYRCVYKP 420

Query: 840  KETGEHLVHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEG--HTFEPAEFIID 1013
             + G H+V V   G  +  SP   V+   E  + +  R SGRGL        E A+F +D
Sbjct: 421  MQPGPHVVKVSFAGDTIPKSPF--VVQVGEACNPNACRASGRGLQPKGIRIRETADFKVD 478

Query: 1014 TRDAGYGGLSLSIEGPSKVD--INTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSP 1187
            T+ AG G L ++I+GP  ++  +  +  +DG     Y P+  G Y ++I +   H+  SP
Sbjct: 479  TKAAGSGELGVTIKGPKGLEELVKQKGFQDGVYAFEYYPSTQGKYSVSITWGGHHIQKSP 538

Query: 1188 FSVKVTGEGRVKESITRRQRAPSVAN--VGSHCDLSLKIPEISIQDMTAQVTSPSGKSHE 1361
            F V+V  E  +++    R   P +    VG   D  ++     +  +   +  PS    E
Sbjct: 539  FEVQVGPEAGMQKV---RAWGPGLHGGIVGRSADFVVESIGSEVGSLGFAIEGPSQAKIE 595

Query: 1362 AEIVEGENHTYC-IRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPL-GEGGAHKVRAGG 1535
                + +N   C +++ P E G + V +    + +  SPF   + P  G+     V+A G
Sbjct: 596  ---YDDQNDGSCDVKYWPKEPGEYAVHIMCDDEDIKDSPFMAYIHPASGDYNPDLVQAYG 652

Query: 1536 PGLERAEAGVP--AEFSIWTREAGAGGLAI-AVEGPSK-AEISFEDRKDGSCGVAYVVQE 1703
            PGLE++   V   AEF++  ++AG   L I A +G  +  +I  + R DG+   +Y   +
Sbjct: 653  PGLEKSGCIVNNLAEFTVDPKDAGKAPLKIFAQDGDGQPIDIQMKSRMDGTYACSYTPVK 712

Query: 1704 PGDYEVSVKFNEEHIPDSPFVVPVASPSGDAR-RLTVSSLQESGLKVNQPASFAVSLNGA 1880
               + ++V +   +IP SP+ V +   S   + ++    ++ SGLK ++P  F V    A
Sbjct: 713  AIKHTIAVVWGGVNIPHSPYRVSIGQGSHPQKVKVFGPGVERSGLKAHEPTHFTVDCTEA 772

Query: 1881 -KGAI------DAKVHSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPG 2039
             +G +      DA+V S      +  +     D + V+++P   G Y I V F    IP 
Sbjct: 773  GEGDVSVGIKCDARVLSDEEEDVDFDIIHNANDTFTVKYVPPAAGRYTIKVLFASQEIPT 832

Query: 2040 SPFKIRVGEPGHGGDPGLVSAYGAGLE--GGVTGSPAEFIVNTSNAGAGALSVTID--GP 2207
            SPF+++V +P H  D   V A G GL   G   G P  F V T  AG   L+V     GP
Sbjct: 833  SPFRVKV-DPSH--DASKVKAEGPGLSKAGVENGKPTHFTVYTKGAGKAPLNVQFSSPGP 889

Query: 2208 SKVKMD---CQECPEGYRVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHS 2378
                 D          + V YTP   G+  + + YGG   I  SPF   V          
Sbjct: 890  GDAVKDLDIIDNYDYSHTVKYTPTQQGNMQVLVTYGGD-PIPKSPFTVGVAA-------- 940

Query: 2379 LHETSSVFVDSLTKTXXXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKA- 2555
                                           S++   GL  ++  VG+   F VD   A 
Sbjct: 941  ---------------------------PLDLSRIKINGLE-NRVEVGKDQEFAVDTRGAG 972

Query: 2556 GNNMLLVGVHGPRTPCEEILVKHVGSRLYSVS-YLLKDKGEYTLVVKWGDEHIPGSPYRV 2732
            G   L V +  P       LV  +  R  S + ++ +++G Y + + +    +PGSPY V
Sbjct: 973  GQGKLDVTILSPSRKVVPCLVAPMAGREGSTAKFIPREEGLYAIDLTYDGHPVPGSPYVV 1032


>ref|XP_002697038.1| PREDICTED: filamin B, beta isoform 2 [Bos taurus].
          Length = 2591

 Score = 1308 bits (3385), Expect = 0.0
 Identities = 625/872 (71%), Positives = 741/872 (84%)
 Frame = +3

Query: 126  PLVGVNGLDVTSLRPFDLVIPFTIKKGEITGEVRMPSGKVAQPAITDNKDGTVTVRYAPS 305
            P+  +NGL     +PFDLVIPF ++KGEITGEV MPSGK A+P I DNKDGTVTVRYAP+
Sbjct: 1724 PVSNMNGL---GFKPFDLVIPFAVRKGEITGEVHMPSGKTAKPEIVDNKDGTVTVRYAPT 1780

Query: 306  EAGLHEMDIRYDNMHIPGSPLQFYVDYVNCGHVTAYGPGLSHGVVNKPAVFTVNTKDAGE 485
            E GLHEM I+Y   HIP SPLQFYV+Y N G V+AYGPGL +GV NK A FT+ T+DAGE
Sbjct: 1781 EVGLHEMHIKYMGSHIPESPLQFYVNYPNSGSVSAYGPGLVYGVANKTATFTIVTEDAGE 1840

Query: 486  GGLSLAIEGPSKAEISCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARVTGD 665
            GGL LAIEGPSKAEISC DN+DGTC+V+YLP LPGDYSILVKYN++HIPGSPFTA++T D
Sbjct: 1841 GGLDLAIEGPSKAEISCIDNKDGTCTVTYLPTLPGDYSILVKYNDKHIPGSPFTAKIT-D 1899

Query: 666  DSMRMSHLKVGSAADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKE 845
            DS R S +K+GSAAD  ++ISETDLS LTA++  PSGR+EPCLLKRL N H+GISF+P+E
Sbjct: 1900 DSRRCSQVKLGSAADFLLDISETDLSTLTASIKAPSGRDEPCLLKRLPNNHIGISFIPRE 1959

Query: 846  TGEHLVHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEGHTFEPAEFIIDTRDA 1025
             GEHLV +KKNG HVA+SP+ +++ QSEIGDA R +V GRGL EG TFE ++FI+DTRDA
Sbjct: 1960 VGEHLVSIKKNGNHVANSPVSIMVVQSEIGDARRAKVYGRGLSEGRTFEMSDFIVDTRDA 2019

Query: 1026 GYGGLSLSIEGPSKVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVT 1205
            GYGG+SL++EGPSKVDI TEDLEDGTC+V+Y PT PG YI++ KFAD+HVPGSPF+VK++
Sbjct: 2020 GYGGISLAVEGPSKVDIQTEDLEDGTCKVSYFPTVPGVYIVSTKFADEHVPGSPFTVKIS 2079

Query: 1206 GEGRVKESITRRQRAPSVANVGSHCDLSLKIPEISIQDMTAQVTSPSGKSHEAEIVEGEN 1385
            GEGRVKESITR  RAPSVA VGS CDL+LKIPEI   DM+A VTSPSG+  EAEIV    
Sbjct: 2080 GEGRVKESITRTSRAPSVATVGSICDLNLKIPEIDSSDMSAHVTSPSGRVTEAEIVPVGK 2139

Query: 1386 HTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLERAEAGV 1565
            +++C+RFVP EMG+HTVSVKY+GQHV GSPFQFTVGPLGEGGAHKVRAGGPGLER EAGV
Sbjct: 2140 NSHCVRFVPQEMGVHTVSVKYRGQHVTGSPFQFTVGPLGEGGAHKVRAGGPGLERGEAGV 2199

Query: 1566 PAEFSIWTREAGAGGLAIAVEGPSKAEISFEDRKDGSCGVAYVVQEPGDYEVSVKFNEEH 1745
            PAEFSIWTREAGAGGL+IAVEGPSKAEI+F+D K+GSCGV+Y+ QEPG+YEVS+KFN+EH
Sbjct: 2200 PAEFSIWTREAGAGGLSIAVEGPSKAEITFDDHKNGSCGVSYIAQEPGNYEVSIKFNDEH 2259

Query: 1746 IPDSPFVVPVASPSGDARRLTVSSLQESGLKVNQPASFAVSLNGAKGAIDAKVHSPSGAL 1925
            IP+SP+VVPV +PS DARRLTV SLQESGLKVNQPASFA+ LNGAKG IDAKVHSPSGA+
Sbjct: 2260 IPESPYVVPVIAPSDDARRLTVLSLQESGLKVNQPASFAIRLNGAKGKIDAKVHSPSGAV 2319

Query: 1926 EECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPGLVSAY 2105
            EEC+V+E++ DKYAVRFIP ENG++ IDVKFNG+H+ GSPFK+RVGEPG  G+P LVSAY
Sbjct: 2320 EECHVSELEPDKYAVRFIPHENGIHTIDVKFNGSHVVGSPFKVRVGEPGQAGNPALVSAY 2379

Query: 2106 GAGLEGGVTGSPAEFIVNTSNAGAGALSVTIDGPSKVKMDCQECPEGYRVTYTPMAPGSY 2285
            GAGLEGG TG  +EF +NT+ AG G LSVTI+GPSKVKMDCQE PEGY+V YTPMAPG+Y
Sbjct: 2380 GAGLEGGSTGIQSEFFINTTRAGPGTLSVTIEGPSKVKMDCQETPEGYKVMYTPMAPGNY 2439

Query: 2286 LISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSVFVDSLTKTXXXXXXXXXXXXXX 2465
            LI +KYGGP HI GSPFKA+VTG RLVS  S +ETSS+ V+S+T++              
Sbjct: 2440 LIGVKYGGPNHIVGSPFKAKVTGQRLVSPGSANETSSILVESVTRSSTETCYSAIPKASS 2499

Query: 2466 XXSKVLAKGLGLSKAYVGQKGSFTVDCSKAGNNMLLVGVHGPRTPCEEILVKHVGSRLYS 2645
              SKV +KG GLSKA++GQK SF VDCSKAG+NMLL+GVHGP TPCEE+ +KHVG++ Y+
Sbjct: 2500 DASKVTSKGAGLSKAFLGQKSSFLVDCSKAGSNMLLIGVHGPTTPCEEVSMKHVGNQQYN 2559

Query: 2646 VSYLLKDKGEYTLVVKWGDEHIPGSPYRVLVP 2741
            V+Y++K++G+Y L VKWG+EHIPGSP+ V VP
Sbjct: 2560 VTYVVKERGDYVLAVKWGEEHIPGSPFHVTVP 2591



 Score =  436 bits (1120), Expect = e-122
 Identities = 287/882 (32%), Positives = 422/882 (47%), Gaps = 25/882 (2%)
 Frame = +3

Query: 168  PFDLVIPFTIK-----KGEITGEVRMPSGKVAQPAITDNKDGTVTVRYAPSEAGLHEMDI 332
            P  L + F I      +G +  ++    GK  +  + DNKDGT  V Y P + G + + +
Sbjct: 1533 PASLPVEFAIDARDAGEGLLAVQITDQEGKPKRAIVHDNKDGTYAVTYIPDKTGRYMIGV 1592

Query: 333  RYDNMHIPGSPLQFYVDYV-NCGHVTAYGPGLSHGVVNKPAV-FTVNTKDAGEGGLSLAI 506
             Y    IP SP +       +     A GPG++  V     V F V+ K AG+G ++  +
Sbjct: 1593 TYGGDDIPLSPYRIRATQTGDASKCLATGPGIASTVKTGEEVGFVVDAKTAGKGKVTCTV 1652

Query: 507  EGP--SKAEISCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARVTGDDSMRM 680
              P  ++AE    +N+DGT  + Y    PG Y I V++    IP SPFT   T  +   +
Sbjct: 1653 LTPDGTEAEADVIENEDGTYDIFYTAAKPGTYVIYVRFGGVDIPNSPFTVMATDGEVAAV 1712

Query: 681  SHLKVGSAADIPIN------ISETDLSL--------LTATVVPPSGREEPCLLKRLRNGH 818
              + V   A +P++          DL +        +T  V  PSG+     +   ++G 
Sbjct: 1713 KEVPVTEEAYVPVSNMNGLGFKPFDLVIPFAVRKGEITGEVHMPSGKTAKPEIVDNKDGT 1772

Query: 819  VGISFVPKETGEHLVHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEGHTFEPA 998
            V + + P E G H +H+K  G H+  SP+   ++    G  S     G GL  G   + A
Sbjct: 1773 VTVRYAPTEVGLHEMHIKYMGSHIPESPLQFYVNYPNSGSVS---AYGPGLVYGVANKTA 1829

Query: 999  EFIIDTRDAGYGGLSLSIEGPSKVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVP 1178
             F I T DAG GGL L+IEGPSK +I+  D +DGTC VTY PT PG+Y I +K+ D+H+P
Sbjct: 1830 TFTIVTEDAGEGGLDLAIEGPSKAEISCIDNKDGTCTVTYLPTLPGDYSILVKYNDKHIP 1889

Query: 1179 GSPFSVKVTGEGRVKESITRRQRAPSVANVGSHCDLSLKIPEISIQDMTAQVTSPSGKSH 1358
            GSPF+ K+T +           R  S   +GS  D  L I E  +  +TA + +PSG+  
Sbjct: 1890 GSPFTAKITDD----------SRRCSQVKLGSAADFLLDISETDLSTLTASIKAPSGRDE 1939

Query: 1359 EAEIVEGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGP 1538
               +    N+   I F+P E+G H VS+K  G HV  SP    V     G A + +  G 
Sbjct: 1940 PCLLKRLPNNHIGISFIPREVGEHLVSIKKNGNHVANSPVSIMVVQSEIGDARRAKVYGR 1999

Query: 1539 GLERAEAGVPAEFSIWTREAGAGGLAIAVEGPSKAEISFEDRKDGSCGVAYVVQEPGDYE 1718
            GL        ++F + TR+AG GG+++AVEGPSK +I  ED +DG+C V+Y    PG Y 
Sbjct: 2000 GLSEGRTFEMSDFIVDTRDAGYGGISLAVEGPSKVDIQTEDLEDGTCKVSYFPTVPGVYI 2059

Query: 1719 VSVKFNEEHIPDSPFVVPVASPSGDARRLTVSSLQESGLKVNQPASFAVSLNGAKGA-ID 1895
            VS KF +EH+P SPF V ++        +T +S   S   V       + +     + + 
Sbjct: 2060 VSTKFADEHVPGSPFTVKISGEGRVKESITRTSRAPSVATVGSICDLNLKIPEIDSSDMS 2119

Query: 1896 AKVHSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGH 2075
            A V SPSG + E  +  + ++ + VRF+P+E GV+ + VK+ G H+ GSPF+  VG  G 
Sbjct: 2120 AHVTSPSGRVTEAEIVPVGKNSHCVRFVPQEMGVHTVSVKYRGQHVTGSPFQFTVGPLGE 2179

Query: 2076 GGDPGLVSAYGAGLEGGVTGSPAEFIVNTSNAGAGALSVTIDGPSKVKMDCQECPEG-YR 2252
            GG    V A G GLE G  G PAEF + T  AGAG LS+ ++GPSK ++   +   G   
Sbjct: 2180 GG-AHKVRAGGPGLERGEAGVPAEFSIWTREAGAGGLSIAVEGPSKAEITFDDHKNGSCG 2238

Query: 2253 VTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSVFVDSLTKTXXX 2432
            V+Y    PG+Y +SIK+    HI  SP+   V                            
Sbjct: 2239 VSYIAQEPGNYEVSIKFNDE-HIPESPYVVPVIA-------------------------- 2271

Query: 2433 XXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKAGNNMLLVGVHGPRTPCEEI 2612
                          ++    L  S   V Q  SF +  + A    +   VH P    EE 
Sbjct: 2272 --------PSDDARRLTVLSLQESGLKVNQPASFAIRLNGA-KGKIDAKVHSPSGAVEEC 2322

Query: 2613 LVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLV 2738
             V  +    Y+V ++  + G +T+ VK+   H+ GSP++V V
Sbjct: 2323 HVSELEPDKYAVRFIPHENGIHTIDVKFNGSHVVGSPFKVRV 2364



 Score =  333 bits (853), Expect = 7e-91
 Identities = 266/887 (29%), Positives = 408/887 (45%), Gaps = 41/887 (4%)
 Frame = +3

Query: 201  KGEITGEVRMPSGKVAQPAITD--NKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQF 374
            +G++   +  PS KV    +     ++G+ T ++ P E GL+ +D+ YD   +PGSP   
Sbjct: 974  QGKLDVTILSPSRKVVPCLVAPMAGREGS-TAKFIPREEGLYAIDLTYDGHPVPGSPYVV 1032

Query: 375  YVDYV-NCGHVTAYGPGLSHGVVNKPAVFTVNTKDAGEGGLSLAIEGPSKAEISCTDNQD 551
                  +   V A+GPGL  G+V KPA FT++TK AG GGL L +EGP +A+I C+DN D
Sbjct: 1033 EASLPPDPTKVKAHGPGLRGGLVGKPAEFTIDTKGAGTGGLGLTVEGPCEAKIECSDNGD 1092

Query: 552  GTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARV--------TGDDSMRMSHLKVGSAA 707
            GTCSVSYLP  PG+Y + + + E HIPGSPF A +               + H KVG   
Sbjct: 1093 GTCSVSYLPTKPGEYFVNILFEEVHIPGSPFKADIEMPFDPSKVVASGPGLEHGKVGEPG 1152

Query: 708  DIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNGQH 887
             + ++ SE     L    V  SG +    ++  ++G   +++VP   G + + +K  G+ 
Sbjct: 1153 LLSVDCSEAGPGTLGLEAVSDSGAKAEVCIENNKDGTYAVTYVPLTAGMYTLTMKYGGEL 1212

Query: 888  VASSPIPVVISQSEIGDASRVRVSGRGLHEGHTFEPA--EFIIDTR---DAGYGGLSLSI 1052
            V   P  V +  +   D SRV+V G G+     F  A  +F +D+R     G   +   I
Sbjct: 1213 VPHFPTRVKVEPAV--DTSRVKVFGPGIEGKDVFREATTDFTVDSRPLTQVGGDHIKAHI 1270

Query: 1053 EGPS--KVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVT------- 1205
              PS    +    D  DGT +V Y P E G +++ + + D  VP SPF V VT       
Sbjct: 1271 ANPSGASTECFVTDNADGTYQVEYTPFEKGLHVVEVTYDDVPVPNSPFKVAVTEGCQPSR 1330

Query: 1206 ----GEGRVKESITRRQRAPSVANVGSHCDLSLKIPEISIQDMTAQVTSPSGKSHEAEIV 1373
                G G +KE+ T +    +V   G+            I  +   V  PS    +    
Sbjct: 1331 VQAQGPG-LKEAFTNKPNVFTVVTRGA-----------GIGGLGITVEGPS--ESKINCR 1376

Query: 1374 EGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGL-ER 1550
            + ++ +    +VP   G + V++ Y G H+PGSPF+  V  + +    KV+  GPGL   
Sbjct: 1377 DNKDGSCSAEYVPFAPGDYDVNITYGGAHIPGSPFRVPVKDVVD--PSKVKIVGPGLGSG 1434

Query: 1551 AEAGVPAEFSIWTREAGAGGLAIAVEGPS--KAEISFEDRKDGSCGVAYVVQEPGDYEVS 1724
              A V   F++ + +AG   L + V GP      ++  D  DG+  V Y   + G Y VS
Sbjct: 1435 VRARVLQSFTVDSSKAGLAPLEVRVMGPRGLVEPVNVVDNGDGTHTVTYTPSQEGPYMVS 1494

Query: 1725 VKFNEEHIPDSPFVVPVASPSGDARRLTVS--SLQESGLKVNQPASFAVSLNGA-KGAID 1895
            VK+ +E IP SPF V V  P+ DA ++T S   L   G+  + P  FA+    A +G + 
Sbjct: 1495 VKYADEEIPRSPFKVKVL-PTYDASKVTASGPGLSTYGVPASLPVEFAIDARDAGEGLLA 1553

Query: 1896 AKVHSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGH 2075
             ++    G  +   V +     YAV +IP + G Y+I V + G  IP SP++IR  +   
Sbjct: 1554 VQITDQEGKPKRAIVHDNKDGTYAVTYIPDKTGRYMIGVTYGGDDIPLSPYRIRATQT-- 1611

Query: 2076 GGDPGLVSAYGAGLEGGV-TGSPAEFIVNTSNAGAGALSVTIDGP--SKVKMDCQECPEG 2246
             GD     A G G+   V TG    F+V+   AG G ++ T+  P  ++ + D  E  +G
Sbjct: 1612 -GDASKCLATGPGIASTVKTGEEVGFVVDAKTAGKGKVTCTVLTPDGTEAEADVIENEDG 1670

Query: 2247 -YRVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSVFVDSLTKT 2423
             Y + YT   PG+Y+I +++GG   I  SPF    T   + +   +  T   +V      
Sbjct: 1671 TYDIFYTAAKPGTYVIYVRFGG-VDIPNSPFTVMATDGEVAAVKEVPVTEEAYVPVSNMN 1729

Query: 2424 XXXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKAGNNMLLVGVHGP--RT 2597
                                 K   L   +  +KG  T +            VH P  +T
Sbjct: 1730 GLGF-----------------KPFDLVIPFAVRKGEITGE------------VHMPSGKT 1760

Query: 2598 PCEEILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLV 2738
               EI+    G+   +V Y   + G + + +K+   HIP SP +  V
Sbjct: 1761 AKPEIVDNKDGT--VTVRYAPTEVGLHEMHIKYMGSHIPESPLQFYV 1805



 Score =  296 bits (758), Expect = 7e-80
 Identities = 240/890 (26%), Positives = 386/890 (43%), Gaps = 47/890 (5%)
 Frame = +3

Query: 201  KGEITGEVRMPSGKVAQPAIT--DNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQF 374
            +G++   V  P G   +  +T   +K+ T +V Y P   GLH++ + +   HI  SP + 
Sbjct: 286  QGDVMVFVEDPEGNKEEALVTPDSDKNKTYSVEYLPKVTGLHKVTVLFAGQHISKSPFEV 345

Query: 375  YVDYV--NCGHVTAYGPGL--SHGVVNKPAVFTVNTKDAGEGGLSLAIEGP---SKAEIS 533
             VD    +   VTA GPGL  +  + NKP  F + T  AG G + + +E P   +  E+ 
Sbjct: 346  NVDKAQGDASKVTAKGPGLEVASNIANKPTYFDIYTAGAGVGDIGVEVEDPQGKNTVELL 405

Query: 534  CTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARV----------TGDDSMRMS 683
              D  +      Y P+ PG + + V +    IP SPF  +V               ++  
Sbjct: 406  VEDRGNQVYRCVYKPMQPGPHVVKVSFAGDTIPKSPFVVQVGEACNPNACRASGRGLQPK 465

Query: 684  HLKVGSAADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLV 863
             +++   AD  ++        L  T+  P G EE    K  ++G     + P   G++ V
Sbjct: 466  GIRIRETADFKVDTKAAGSGELGVTIKGPKGLEELVKQKGFQDGVYAFEYYPSTQGKYSV 525

Query: 864  HVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEGHTFEPAEFIIDTRDAGYGGLS 1043
             +   G H+  SP  V +         +VR  G GLH G     A+F++++  +  G L 
Sbjct: 526  SITWGGHHIQKSPFEVQVGPE--AGMQKVRAWGPGLHGGIVGRSADFVVESIGSEVGSLG 583

Query: 1044 LSIEGPSKVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKV-TGEGRV 1220
             +IEGPS+  I  +D  DG+C V Y P EPG Y ++I   D+ +  SPF   +    G  
Sbjct: 584  FAIEGPSQAKIEYDDQNDGSCDVKYWPKEPGEYAVHIMCDDEDIKDSPFMAYIHPASGDY 643

Query: 1221 KESITRRQ---RAPSVANVGSHCDLSLKIPEISIQDMTAQVTSPSGKSHEAEIVEGENHT 1391
               + +        S   V +  + ++   +     +        G+  + ++    + T
Sbjct: 644  NPDLVQAYGPGLEKSGCIVNNLAEFTVDPKDAGKAPLKIFAQDGDGQPIDIQMKSRMDGT 703

Query: 1392 YCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAH--KVRAGGPGLERA--EA 1559
            Y   + P +   HT++V + G ++P SP++ ++G     G+H  KV+  GPG+ER+  +A
Sbjct: 704  YACSYTPVKAIKHTIAVVWGGVNIPHSPYRVSIGQ----GSHPQKVKVFGPGVERSGLKA 759

Query: 1560 GVPAEFSIWTREAGAGGLAIAVE------GPSKAEISFE--DRKDGSCGVAYVVQEPGDY 1715
              P  F++   EAG G +++ ++         + ++ F+     + +  V YV    G Y
Sbjct: 760  HEPTHFTVDCTEAGEGDVSVGIKCDARVLSDEEEDVDFDIIHNANDTFTVKYVPPAAGRY 819

Query: 1716 EVSVKFNEEHIPDSPFVVPVASPSGDARRLTVS--SLQESGLKVNQPASFAVSLNGA-KG 1886
             + V F  + IP SPF V V  PS DA ++      L ++G++  +P  F V   GA K 
Sbjct: 820  TIKVLFASQEIPTSPFRVKV-DPSHDASKVKAEGPGLSKAGVENGKPTHFTVYTKGAGKA 878

Query: 1887 AIDAKVHS--PSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRV 2060
             ++ +  S  P  A+++  + +     + V++ P + G   + V + G  IP SPF + V
Sbjct: 879  PLNVQFSSPGPGDAVKDLDIIDNYDYSHTVKYTPTQQGNMQVLVTYGGDPIPKSPFTVGV 938

Query: 2061 GEPGHGGDPGLVSAYGAGLEGGV-TGSPAEFIVNTSNAGA-GALSVTIDGPSKVKMDCQE 2234
              P       L      GLE  V  G   EF V+T  AG  G L VTI  PS+  + C  
Sbjct: 939  AAP-----LDLSRIKINGLENRVEVGKDQEFAVDTRGAGGQGKLDVTILSPSRKVVPCLV 993

Query: 2235 CP----EGYRVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSVF 2402
             P    EG    + P   G Y I + Y G + + GSP+    +                 
Sbjct: 994  APMAGREGSTAKFIPREEGLYAIDLTYDG-HPVPGSPYVVEAS----------------- 1035

Query: 2403 VDSLTKTXXXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKAGNNMLLVGV 2582
                                   +KV A G GL    VG+   FT+D   AG   L + V
Sbjct: 1036 ------------------LPPDPTKVKAHGPGLRGGLVGKPAEFTIDTKGAGTGGLGLTV 1077

Query: 2583 HGPRTPCE-EILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYR 2729
             G   PCE +I     G    SVSYL    GEY + + + + HIPGSP++
Sbjct: 1078 EG---PCEAKIECSDNGDGTCSVSYLPTKPGEYFVNILFEEVHIPGSPFK 1124



 Score =  277 bits (709), Expect = 4e-74
 Identities = 238/885 (26%), Positives = 379/885 (42%), Gaps = 40/885 (4%)
 Frame = +3

Query: 204  GEITGEVRMPSGKVAQPAITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFYVD 383
            GE+   ++ P G          +DG     Y PS  G + + I +   HI  SP +  V 
Sbjct: 485  GELGVTIKGPKGLEELVKQKGFQDGVYAFEYYPSTQGKYSVSITWGGHHIQKSPFEVQVG 544

Query: 384  -YVNCGHVTAYGPGLSHGVVNKPAVFTVNTKDAGEGGLSLAIEGPSKAEISCTDNQDGTC 560
                   V A+GPGL  G+V + A F V +  +  G L  AIEGPS+A+I   D  DG+C
Sbjct: 545  PEAGMQKVRAWGPGLHGGIVGRSADFVVESIGSEVGSLGFAIEGPSQAKIEYDDQNDGSC 604

Query: 561  SVSYLPVLPGDYSILVKYNEQHIPGSPFTARV---TGD----------DSMRMSHLKVGS 701
             V Y P  PG+Y++ +  +++ I  SPF A +   +GD            +  S   V +
Sbjct: 605  DVKYWPKEPGEYAVHIMCDDEDIKDSPFMAYIHPASGDYNPDLVQAYGPGLEKSGCIVNN 664

Query: 702  AADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNG 881
             A+  ++  +   + L        G+     +K   +G    S+ P +  +H + V   G
Sbjct: 665  LAEFTVDPKDAGKAPLKIFAQDGDGQPIDIQMKSRMDGTYACSYTPVKAIKHTIAVVWGG 724

Query: 882  QHVASSPIPVVISQSEIGDASRVRVSGRGLHEG--HTFEPAEFIIDTRDAGYGGLSLSIE 1055
             ++  SP  V I Q       +V+V G G+        EP  F +D  +AG G +S+ I+
Sbjct: 725  VNIPHSPYRVSIGQG--SHPQKVKVFGPGVERSGLKAHEPTHFTVDCTEAGEGDVSVGIK 782

Query: 1056 GPSKVDINTEDLED--------GTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVT-- 1205
              ++V  + E+  D         T  V Y P   G Y I + FA Q +P SPF VKV   
Sbjct: 783  CDARVLSDEEEDVDFDIIHNANDTFTVKYVPPAAGRYTIKVLFASQEIPTSPFRVKVDPS 842

Query: 1206 -GEGRVKESITRRQRAPSVANVGSHCDLSLKIPEISIQDMTAQVTSPSGKSHEAEIVEGE 1382
                +VK       +A       +H  +  K    +  ++      P     + +I++  
Sbjct: 843  HDASKVKAEGPGLSKAGVENGKPTHFTVYTKGAGKAPLNVQFSSPGPGDAVKDLDIIDNY 902

Query: 1383 NHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLE-RAEA 1559
            ++++ +++ P + G   V V Y G  +P SP  FTVG        +++    GLE R E 
Sbjct: 903  DYSHTVKYTPTQQGNMQVLVTYGGDPIPKSP--FTVGVAAPLDLSRIKIN--GLENRVEV 958

Query: 1560 GVPAEFSIWTREAGA-GGLAIAVEGPSK----AEISFEDRKDGSCGVAYVVQEPGDYEVS 1724
            G   EF++ TR AG  G L + +  PS+      ++    ++GS    ++ +E G Y + 
Sbjct: 959  GKDQEFAVDTRGAGGQGKLDVTILSPSRKVVPCLVAPMAGREGST-AKFIPREEGLYAID 1017

Query: 1725 VKFNEEHIPDSPFVVPVASPSGDARRLTVSSLQESGLKVNQPASFAVSLNGA-KGAIDAK 1901
            + ++   +P SP+VV  + P  D  ++        G  V +PA F +   GA  G +   
Sbjct: 1018 LTYDGHPVPGSPYVVEASLPP-DPTKVKAHGPGLRGGLVGKPAEFTIDTKGAGTGGLGLT 1076

Query: 1902 VHSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGG 2081
            V  P  A  EC  ++      +V ++P + G Y +++ F   HIPGSPFK  +  P    
Sbjct: 1077 VEGPCEAKIEC--SDNGDGTCSVSYLPTKPGEYFVNILFEEVHIPGSPFKADIEMP---F 1131

Query: 2082 DPGLVSAYGAGLEGGVTGSPAEFIVNTSNAGAGALSV--TIDGPSKVKMDCQECPEG-YR 2252
            DP  V A G GLE G  G P    V+ S AG G L +    D  +K ++  +   +G Y 
Sbjct: 1132 DPSKVVASGPGLEHGKVGEPGLLSVDCSEAGPGTLGLEAVSDSGAKAEVCIENNKDGTYA 1191

Query: 2253 VTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSVFVDSLTKTXXX 2432
            VTY P+  G Y +++KYGG   +   P + +V            +TS V           
Sbjct: 1192 VTYVPLTAGMYTLTMKYGGEL-VPHFPTRVKV--------EPAVDTSRV----------- 1231

Query: 2433 XXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVD---CSKAGNNMLLVGVHGPRTPC 2603
                          KV   G+     +      FTVD    ++ G + +   +  P    
Sbjct: 1232 --------------KVFGPGIEGKDVFREATTDFTVDSRPLTQVGGDHIKAHIANPSGAS 1277

Query: 2604 EEILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLV 2738
             E  V       Y V Y   +KG + + V + D  +P SP++V V
Sbjct: 1278 TECFVTDNADGTYQVEYTPFEKGLHVVEVTYDDVPVPNSPFKVAV 1322



 Score =  252 bits (643), Expect = 2e-66
 Identities = 201/687 (29%), Positives = 308/687 (44%), Gaps = 29/687 (4%)
 Frame = +3

Query: 759  VVPPSGREEPCLLK--RLRNGHVGISFVPKETGEHLVHVKKNGQHVASSPIPVVISQSEI 932
            V  P G +E  L+     +N    + ++PK TG H V V   GQH++ SP  V + +++ 
Sbjct: 293  VEDPEGNKEEALVTPDSDKNKTYSVEYLPKVTGLHKVTVLFAGQHISKSPFEVNVDKAQ- 351

Query: 933  GDASRVRVSGRGLHEGHTF--EPAEFIIDTRDAGYGGLSLSIEGP---SKVDINTEDLED 1097
            GDAS+V   G GL        +P  F I T  AG G + + +E P   + V++  ED  +
Sbjct: 352  GDASKVTAKGPGLEVASNIANKPTYFDIYTAGAGVGDIGVEVEDPQGKNTVELLVEDRGN 411

Query: 1098 GTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTGEGRVKESITRRQRA--PSVANVG 1271
               R  Y P +PG +++ + FA   +P SPF V+V GE     +     R   P    + 
Sbjct: 412  QVYRCVYKPMQPGPHVVKVSFAGDTIPKSPFVVQV-GEACNPNACRASGRGLQPKGIRIR 470

Query: 1272 SHCDLSLKIPEISIQDMTAQVTSPSGKSHEAEIVEGENHTYCIRFVPAEMGMHTVSVKYK 1451
               D  +        ++   +  P G     +    ++  Y   + P+  G ++VS+ + 
Sbjct: 471  ETADFKVDTKAAGSGELGVTIKGPKGLEELVKQKGFQDGVYAFEYYPSTQGKYSVSITWG 530

Query: 1452 GQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLERAEAGVPAEFSIWTREAGAGGLAIAVEG 1631
            G H+  SPF+  VGP  E G  KVRA GPGL     G  A+F + +  +  G L  A+EG
Sbjct: 531  GHHIQKSPFEVQVGP--EAGMQKVRAWGPGLHGGIVGRSADFVVESIGSEVGSLGFAIEG 588

Query: 1632 PSKAEISFEDRKDGSCGVAYVVQEPGDYEVSVKFNEEHIPDSPFVVPVASPSGDARRLTV 1811
            PS+A+I ++D+ DGSC V Y  +EPG+Y V +  ++E I DSPF+  +   SGD     V
Sbjct: 589  PSQAKIEYDDQNDGSCDVKYWPKEPGEYAVHIMCDDEDIKDSPFMAYIHPASGDYNPDLV 648

Query: 1812 SS----LQESGLKVNQPASFAVSLNGA-KGAIDAKVHSPSGALEECYVTEIDQDKYAVRF 1976
             +    L++SG  VN  A F V    A K  +        G   +  +       YA  +
Sbjct: 649  QAYGPGLEKSGCIVNNLAEFTVDPKDAGKAPLKIFAQDGDGQPIDIQMKSRMDGTYACSY 708

Query: 1977 IPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPGLVSAYGAGLE--GGVTGSPAEF 2150
             P +   + I V + G +IP SP+++ +G+  H   P  V  +G G+E  G     P  F
Sbjct: 709  TPVKAIKHTIAVVWGGVNIPHSPYRVSIGQGSH---PQKVKVFGPGVERSGLKAHEPTHF 765

Query: 2151 IVNTSNAGAGALSVTIDGPSKVKMDCQE---------CPEGYRVTYTPMAPGSYLISIKY 2303
             V+ + AG G +SV I   ++V  D +E           + + V Y P A G Y I + +
Sbjct: 766  TVDCTEAGEGDVSVGIKCDARVLSDEEEDVDFDIIHNANDTFTVKYVPPAAGRYTIKVLF 825

Query: 2304 GGPYHIGGSPFKARVTGHRLVSNHSLHETSSVFVDSLTKTXXXXXXXXXXXXXXXXSKVL 2483
                 I  SPF+ +V       +H                                SKV 
Sbjct: 826  AS-QEIPTSPFRVKVD-----PSHD------------------------------ASKVK 849

Query: 2484 AKGLGLSKAYV--GQKGSFTVDCSKAGNNMLLV--GVHGPRTPCEEILVKHVGSRLYSVS 2651
            A+G GLSKA V  G+   FTV    AG   L V     GP    +++ +       ++V 
Sbjct: 850  AEGPGLSKAGVENGKPTHFTVYTKGAGKAPLNVQFSSPGPGDAVKDLDIIDNYDYSHTVK 909

Query: 2652 YLLKDKGEYTLVVKWGDEHIPGSPYRV 2732
            Y    +G   ++V +G + IP SP+ V
Sbjct: 910  YTPTQQGNMQVLVTYGGDPIPKSPFTV 936



 Score =  222 bits (566), Expect = 1e-57
 Identities = 229/840 (27%), Positives = 359/840 (42%), Gaps = 47/840 (5%)
 Frame = +3

Query: 354  PGSPLQFYVDYVNCGHVTAYGPGL--SHGVVNKPAVFTVNTKDAGEGGLSLAIEGP--SK 521
            PG+PL+     +N     AYG G+  +  +V +PA FTV+T  AG+G + + +E P  +K
Sbjct: 244  PGAPLK---PKLNPKKARAYGRGIEPTGNMVKQPAKFTVDTISAGQGDVMVFVEDPEGNK 300

Query: 522  AEISCTDNQD--GTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARVTGDDSMRMSHLKV 695
             E   T + D   T SV YLP + G + + V +  QHI  SPF   V             
Sbjct: 301  EEALVTPDSDKNKTYSVEYLPKVTGLHKVTVLFAGQHISKSPFEVNVDKAQGDASKVTAK 360

Query: 696  GSAADIPINISE--TDLSLLTA---------TVVPPSGREEPCLLKRLRNGHV-GISFVP 839
            G   ++  NI+   T   + TA          V  P G+    LL   R   V    + P
Sbjct: 361  GPGLEVASNIANKPTYFDIYTAGAGVGDIGVEVEDPQGKNTVELLVEDRGNQVYRCVYKP 420

Query: 840  KETGEHLVHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEG--HTFEPAEFIID 1013
             + G H+V V   G  +  SP   V+   E  + +  R SGRGL        E A+F +D
Sbjct: 421  MQPGPHVVKVSFAGDTIPKSPF--VVQVGEACNPNACRASGRGLQPKGIRIRETADFKVD 478

Query: 1014 TRDAGYGGLSLSIEGPSKVD--INTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSP 1187
            T+ AG G L ++I+GP  ++  +  +  +DG     Y P+  G Y ++I +   H+  SP
Sbjct: 479  TKAAGSGELGVTIKGPKGLEELVKQKGFQDGVYAFEYYPSTQGKYSVSITWGGHHIQKSP 538

Query: 1188 FSVKVTGEGRVKESITRRQRAPSVAN--VGSHCDLSLKIPEISIQDMTAQVTSPSGKSHE 1361
            F V+V  E  +++    R   P +    VG   D  ++     +  +   +  PS    E
Sbjct: 539  FEVQVGPEAGMQKV---RAWGPGLHGGIVGRSADFVVESIGSEVGSLGFAIEGPSQAKIE 595

Query: 1362 AEIVEGENHTYC-IRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPL-GEGGAHKVRAGG 1535
                + +N   C +++ P E G + V +    + +  SPF   + P  G+     V+A G
Sbjct: 596  ---YDDQNDGSCDVKYWPKEPGEYAVHIMCDDEDIKDSPFMAYIHPASGDYNPDLVQAYG 652

Query: 1536 PGLERAEAGVP--AEFSIWTREAGAGGLAI-AVEGPSK-AEISFEDRKDGSCGVAYVVQE 1703
            PGLE++   V   AEF++  ++AG   L I A +G  +  +I  + R DG+   +Y   +
Sbjct: 653  PGLEKSGCIVNNLAEFTVDPKDAGKAPLKIFAQDGDGQPIDIQMKSRMDGTYACSYTPVK 712

Query: 1704 PGDYEVSVKFNEEHIPDSPFVVPVASPSGDAR-RLTVSSLQESGLKVNQPASFAVSLNGA 1880
               + ++V +   +IP SP+ V +   S   + ++    ++ SGLK ++P  F V    A
Sbjct: 713  AIKHTIAVVWGGVNIPHSPYRVSIGQGSHPQKVKVFGPGVERSGLKAHEPTHFTVDCTEA 772

Query: 1881 -KGAI------DAKVHSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPG 2039
             +G +      DA+V S      +  +     D + V+++P   G Y I V F    IP 
Sbjct: 773  GEGDVSVGIKCDARVLSDEEEDVDFDIIHNANDTFTVKYVPPAAGRYTIKVLFASQEIPT 832

Query: 2040 SPFKIRVGEPGHGGDPGLVSAYGAGLE--GGVTGSPAEFIVNTSNAGAGALSVTID--GP 2207
            SPF+++V +P H  D   V A G GL   G   G P  F V T  AG   L+V     GP
Sbjct: 833  SPFRVKV-DPSH--DASKVKAEGPGLSKAGVENGKPTHFTVYTKGAGKAPLNVQFSSPGP 889

Query: 2208 SKVKMD---CQECPEGYRVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHS 2378
                 D          + V YTP   G+  + + YGG   I  SPF   V          
Sbjct: 890  GDAVKDLDIIDNYDYSHTVKYTPTQQGNMQVLVTYGGD-PIPKSPFTVGVAA-------- 940

Query: 2379 LHETSSVFVDSLTKTXXXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKA- 2555
                                           S++   GL  ++  VG+   F VD   A 
Sbjct: 941  ---------------------------PLDLSRIKINGLE-NRVEVGKDQEFAVDTRGAG 972

Query: 2556 GNNMLLVGVHGPRTPCEEILVKHVGSRLYSVS-YLLKDKGEYTLVVKWGDEHIPGSPYRV 2732
            G   L V +  P       LV  +  R  S + ++ +++G Y + + +    +PGSPY V
Sbjct: 973  GQGKLDVTILSPSRKVVPCLVAPMAGREGSTAKFIPREEGLYAIDLTYDGHPVPGSPYVV 1032


>ref|XP_002702811.1| PREDICTED: filamin B, beta [Bos taurus].
          Length = 2578

 Score = 1308 bits (3385), Expect = 0.0
 Identities = 625/872 (71%), Positives = 741/872 (84%)
 Frame = +3

Query: 126  PLVGVNGLDVTSLRPFDLVIPFTIKKGEITGEVRMPSGKVAQPAITDNKDGTVTVRYAPS 305
            P+  +NGL     +PFDLVIPF ++KGEITGEV MPSGK A+P I DNKDGTVTVRYAP+
Sbjct: 1711 PVSNMNGL---GFKPFDLVIPFAVRKGEITGEVHMPSGKTAKPEIVDNKDGTVTVRYAPT 1767

Query: 306  EAGLHEMDIRYDNMHIPGSPLQFYVDYVNCGHVTAYGPGLSHGVVNKPAVFTVNTKDAGE 485
            E GLHEM I+Y   HIP SPLQFYV+Y N G V+AYGPGL +GV NK A FT+ T+DAGE
Sbjct: 1768 EVGLHEMHIKYMGSHIPESPLQFYVNYPNSGSVSAYGPGLVYGVANKTATFTIVTEDAGE 1827

Query: 486  GGLSLAIEGPSKAEISCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARVTGD 665
            GGL LAIEGPSKAEISC DN+DGTC+V+YLP LPGDYSILVKYN++HIPGSPFTA++T D
Sbjct: 1828 GGLDLAIEGPSKAEISCIDNKDGTCTVTYLPTLPGDYSILVKYNDKHIPGSPFTAKIT-D 1886

Query: 666  DSMRMSHLKVGSAADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKE 845
            DS R S +K+GSAAD  ++ISETDLS LTA++  PSGR+EPCLLKRL N H+GISF+P+E
Sbjct: 1887 DSRRCSQVKLGSAADFLLDISETDLSTLTASIKAPSGRDEPCLLKRLPNNHIGISFIPRE 1946

Query: 846  TGEHLVHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEGHTFEPAEFIIDTRDA 1025
             GEHLV +KKNG HVA+SP+ +++ QSEIGDA R +V GRGL EG TFE ++FI+DTRDA
Sbjct: 1947 VGEHLVSIKKNGNHVANSPVSIMVVQSEIGDARRAKVYGRGLSEGRTFEMSDFIVDTRDA 2006

Query: 1026 GYGGLSLSIEGPSKVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVT 1205
            GYGG+SL++EGPSKVDI TEDLEDGTC+V+Y PT PG YI++ KFAD+HVPGSPF+VK++
Sbjct: 2007 GYGGISLAVEGPSKVDIQTEDLEDGTCKVSYFPTVPGVYIVSTKFADEHVPGSPFTVKIS 2066

Query: 1206 GEGRVKESITRRQRAPSVANVGSHCDLSLKIPEISIQDMTAQVTSPSGKSHEAEIVEGEN 1385
            GEGRVKESITR  RAPSVA VGS CDL+LKIPEI   DM+A VTSPSG+  EAEIV    
Sbjct: 2067 GEGRVKESITRTSRAPSVATVGSICDLNLKIPEIDSSDMSAHVTSPSGRVTEAEIVPVGK 2126

Query: 1386 HTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLERAEAGV 1565
            +++C+RFVP EMG+HTVSVKY+GQHV GSPFQFTVGPLGEGGAHKVRAGGPGLER EAGV
Sbjct: 2127 NSHCVRFVPQEMGVHTVSVKYRGQHVTGSPFQFTVGPLGEGGAHKVRAGGPGLERGEAGV 2186

Query: 1566 PAEFSIWTREAGAGGLAIAVEGPSKAEISFEDRKDGSCGVAYVVQEPGDYEVSVKFNEEH 1745
            PAEFSIWTREAGAGGL+IAVEGPSKAEI+F+D K+GSCGV+Y+ QEPG+YEVS+KFN+EH
Sbjct: 2187 PAEFSIWTREAGAGGLSIAVEGPSKAEITFDDHKNGSCGVSYIAQEPGNYEVSIKFNDEH 2246

Query: 1746 IPDSPFVVPVASPSGDARRLTVSSLQESGLKVNQPASFAVSLNGAKGAIDAKVHSPSGAL 1925
            IP+SP+VVPV +PS DARRLTV SLQESGLKVNQPASFA+ LNGAKG IDAKVHSPSGA+
Sbjct: 2247 IPESPYVVPVIAPSDDARRLTVLSLQESGLKVNQPASFAIRLNGAKGKIDAKVHSPSGAV 2306

Query: 1926 EECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPGLVSAY 2105
            EEC+V+E++ DKYAVRFIP ENG++ IDVKFNG+H+ GSPFK+RVGEPG  G+P LVSAY
Sbjct: 2307 EECHVSELEPDKYAVRFIPHENGIHTIDVKFNGSHVVGSPFKVRVGEPGQAGNPALVSAY 2366

Query: 2106 GAGLEGGVTGSPAEFIVNTSNAGAGALSVTIDGPSKVKMDCQECPEGYRVTYTPMAPGSY 2285
            GAGLEGG TG  +EF +NT+ AG G LSVTI+GPSKVKMDCQE PEGY+V YTPMAPG+Y
Sbjct: 2367 GAGLEGGSTGIQSEFFINTTRAGPGTLSVTIEGPSKVKMDCQETPEGYKVMYTPMAPGNY 2426

Query: 2286 LISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSVFVDSLTKTXXXXXXXXXXXXXX 2465
            LI +KYGGP HI GSPFKA+VTG RLVS  S +ETSS+ V+S+T++              
Sbjct: 2427 LIGVKYGGPNHIVGSPFKAKVTGQRLVSPGSANETSSILVESVTRSSTETCYSAIPKASS 2486

Query: 2466 XXSKVLAKGLGLSKAYVGQKGSFTVDCSKAGNNMLLVGVHGPRTPCEEILVKHVGSRLYS 2645
              SKV +KG GLSKA++GQK SF VDCSKAG+NMLL+GVHGP TPCEE+ +KHVG++ Y+
Sbjct: 2487 DASKVTSKGAGLSKAFLGQKSSFLVDCSKAGSNMLLIGVHGPTTPCEEVSMKHVGNQQYN 2546

Query: 2646 VSYLLKDKGEYTLVVKWGDEHIPGSPYRVLVP 2741
            V+Y++K++G+Y L VKWG+EHIPGSP+ V VP
Sbjct: 2547 VTYVVKERGDYVLAVKWGEEHIPGSPFHVTVP 2578



 Score =  434 bits (1115), Expect = e-121
 Identities = 287/872 (32%), Positives = 424/872 (48%), Gaps = 15/872 (1%)
 Frame = +3

Query: 168  PFDLVIPFTIK-----KGEITGEVRMPSGKVAQPAITDNKDGTVTVRYAPSEAGLHEMDI 332
            P  L + F I      +G +  ++    GK  +  + DNKDGT  V Y P + G + + +
Sbjct: 1533 PASLPVEFAIDARDAGEGLLAVQITDQEGKPKRAIVHDNKDGTYAVTYIPDKTGRYMIGV 1592

Query: 333  RYDNMHIPGSPLQFYVDYV-NCGHVTAYGPGLSHGVVNKPAV-FTVNTKDAGEGGLSLAI 506
             Y    IP SP +       +     A GPG++  V     V F V+ K AG+G ++  +
Sbjct: 1593 TYGGDDIPLSPYRIRATQTGDASKCLATGPGIASTVKTGEEVGFVVDAKTAGKGKVTCTV 1652

Query: 507  EGP--SKAEISCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARVTGDDSMRM 680
              P  ++AE    +N+DGT  + Y    PG Y I V++    IP SPFT  VT +  + +
Sbjct: 1653 LTPDGTEAEADVIENEDGTYDIFYTAAKPGTYVIYVRFGGVDIPNSPFTVMVTEEAYVPV 1712

Query: 681  SHLK-VGSA---ADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKET 848
            S++  +G       IP  + + +   +T  V  PSG+     +   ++G V + + P E 
Sbjct: 1713 SNMNGLGFKPFDLVIPFAVRKGE---ITGEVHMPSGKTAKPEIVDNKDGTVTVRYAPTEV 1769

Query: 849  GEHLVHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEGHTFEPAEFIIDTRDAG 1028
            G H +H+K  G H+  SP+   ++    G  S     G GL  G   + A F I T DAG
Sbjct: 1770 GLHEMHIKYMGSHIPESPLQFYVNYPNSGSVS---AYGPGLVYGVANKTATFTIVTEDAG 1826

Query: 1029 YGGLSLSIEGPSKVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTG 1208
             GGL L+IEGPSK +I+  D +DGTC VTY PT PG+Y I +K+ D+H+PGSPF+ K+T 
Sbjct: 1827 EGGLDLAIEGPSKAEISCIDNKDGTCTVTYLPTLPGDYSILVKYNDKHIPGSPFTAKITD 1886

Query: 1209 EGRVKESITRRQRAPSVANVGSHCDLSLKIPEISIQDMTAQVTSPSGKSHEAEIVEGENH 1388
            +           R  S   +GS  D  L I E  +  +TA + +PSG+     +    N+
Sbjct: 1887 D----------SRRCSQVKLGSAADFLLDISETDLSTLTASIKAPSGRDEPCLLKRLPNN 1936

Query: 1389 TYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLERAEAGVP 1568
               I F+P E+G H VS+K  G HV  SP    V     G A + +  G GL        
Sbjct: 1937 HIGISFIPREVGEHLVSIKKNGNHVANSPVSIMVVQSEIGDARRAKVYGRGLSEGRTFEM 1996

Query: 1569 AEFSIWTREAGAGGLAIAVEGPSKAEISFEDRKDGSCGVAYVVQEPGDYEVSVKFNEEHI 1748
            ++F + TR+AG GG+++AVEGPSK +I  ED +DG+C V+Y    PG Y VS KF +EH+
Sbjct: 1997 SDFIVDTRDAGYGGISLAVEGPSKVDIQTEDLEDGTCKVSYFPTVPGVYIVSTKFADEHV 2056

Query: 1749 PDSPFVVPVASPSGDARRLTVSSLQESGLKVNQPASFAVSLNGAKGA-IDAKVHSPSGAL 1925
            P SPF V ++        +T +S   S   V       + +     + + A V SPSG +
Sbjct: 2057 PGSPFTVKISGEGRVKESITRTSRAPSVATVGSICDLNLKIPEIDSSDMSAHVTSPSGRV 2116

Query: 1926 EECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPGLVSAY 2105
             E  +  + ++ + VRF+P+E GV+ + VK+ G H+ GSPF+  VG  G GG    V A 
Sbjct: 2117 TEAEIVPVGKNSHCVRFVPQEMGVHTVSVKYRGQHVTGSPFQFTVGPLGEGG-AHKVRAG 2175

Query: 2106 GAGLEGGVTGSPAEFIVNTSNAGAGALSVTIDGPSKVKMDCQECPEG-YRVTYTPMAPGS 2282
            G GLE G  G PAEF + T  AGAG LS+ ++GPSK ++   +   G   V+Y    PG+
Sbjct: 2176 GPGLERGEAGVPAEFSIWTREAGAGGLSIAVEGPSKAEITFDDHKNGSCGVSYIAQEPGN 2235

Query: 2283 YLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSVFVDSLTKTXXXXXXXXXXXXX 2462
            Y +SIK+    HI  SP+   V                                      
Sbjct: 2236 YEVSIKFNDE-HIPESPYVVPVIA----------------------------------PS 2260

Query: 2463 XXXSKVLAKGLGLSKAYVGQKGSFTVDCSKAGNNMLLVGVHGPRTPCEEILVKHVGSRLY 2642
                ++    L  S   V Q  SF +  + A    +   VH P    EE  V  +    Y
Sbjct: 2261 DDARRLTVLSLQESGLKVNQPASFAIRLNGA-KGKIDAKVHSPSGAVEECHVSELEPDKY 2319

Query: 2643 SVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLV 2738
            +V ++  + G +T+ VK+   H+ GSP++V V
Sbjct: 2320 AVRFIPHENGIHTIDVKFNGSHVVGSPFKVRV 2351



 Score =  332 bits (852), Expect = 9e-91
 Identities = 243/756 (32%), Positives = 368/756 (48%), Gaps = 39/756 (5%)
 Frame = +3

Query: 201  KGEITGEVRMPSGKVAQPAITD--NKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQF 374
            +G++   +  PS KV    +     ++G+ T ++ P E GL+ +D+ YD   +PGSP   
Sbjct: 974  QGKLDVTILSPSRKVVPCLVAPMAGREGS-TAKFIPREEGLYAIDLTYDGHPVPGSPYVV 1032

Query: 375  YVDYV-NCGHVTAYGPGLSHGVVNKPAVFTVNTKDAGEGGLSLAIEGPSKAEISCTDNQD 551
                  +   V A+GPGL  G+V KPA FT++TK AG GGL L +EGP +A+I C+DN D
Sbjct: 1033 EASLPPDPTKVKAHGPGLRGGLVGKPAEFTIDTKGAGTGGLGLTVEGPCEAKIECSDNGD 1092

Query: 552  GTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARV--------TGDDSMRMSHLKVGSAA 707
            GTCSVSYLP  PG+Y + + + E HIPGSPF A +               + H KVG   
Sbjct: 1093 GTCSVSYLPTKPGEYFVNILFEEVHIPGSPFKADIEMPFDPSKVVASGPGLEHGKVGEPG 1152

Query: 708  DIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNGQH 887
             + ++ SE     L    V  SG +    ++  ++G   +++VP   G + + +K  G+ 
Sbjct: 1153 LLSVDCSEAGPGTLGLEAVSDSGAKAEVCIENNKDGTYAVTYVPLTAGMYTLTMKYGGEL 1212

Query: 888  VASSPIPVVISQSEIGDASRVRVSGRGLHEGHTFEPA--EFIIDTR---DAGYGGLSLSI 1052
            V   P  V +  +   D SRV+V G G+     F  A  +F +D+R     G   +   I
Sbjct: 1213 VPHFPTRVKVEPAV--DTSRVKVFGPGIEGKDVFREATTDFTVDSRPLTQVGGDHIKAHI 1270

Query: 1053 EGPS--KVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVT------- 1205
              PS    +    D  DGT +V Y P E G +++ + + D  VP SPF V VT       
Sbjct: 1271 ANPSGASTECFVTDNADGTYQVEYTPFEKGLHVVEVTYDDVPVPNSPFKVAVTEGCQPSR 1330

Query: 1206 ----GEGRVKESITRRQRAPSVANVGSHCDLSLKIPEISIQDMTAQVTSPSGKSHEAEIV 1373
                G G +KE+ T +    +V   G+            I  +   V  PS    +    
Sbjct: 1331 VQAQGPG-LKEAFTNKPNVFTVVTRGA-----------GIGGLGITVEGPS--ESKINCR 1376

Query: 1374 EGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGL-ER 1550
            + ++ +    +VP   G + V++ Y G H+PGSPF+  V  + +    KV+  GPGL   
Sbjct: 1377 DNKDGSCSAEYVPFAPGDYDVNITYGGAHIPGSPFRVPVKDVVD--PSKVKIVGPGLGSG 1434

Query: 1551 AEAGVPAEFSIWTREAGAGGLAIAVEGPS--KAEISFEDRKDGSCGVAYVVQEPGDYEVS 1724
              A V   F++ + +AG   L + V GP      ++  D  DG+  V Y   + G Y VS
Sbjct: 1435 VRARVLQSFTVDSSKAGLAPLEVRVMGPRGLVEPVNVVDNGDGTHTVTYTPSQEGPYMVS 1494

Query: 1725 VKFNEEHIPDSPFVVPVASPSGDARRLTVS--SLQESGLKVNQPASFAVSLNGA-KGAID 1895
            VK+ +E IP SPF V V  P+ DA ++T S   L   G+  + P  FA+    A +G + 
Sbjct: 1495 VKYADEEIPRSPFKVKVL-PTYDASKVTASGPGLSTYGVPASLPVEFAIDARDAGEGLLA 1553

Query: 1896 AKVHSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGH 2075
             ++    G  +   V +     YAV +IP + G Y+I V + G  IP SP++IR  +   
Sbjct: 1554 VQITDQEGKPKRAIVHDNKDGTYAVTYIPDKTGRYMIGVTYGGDDIPLSPYRIRATQT-- 1611

Query: 2076 GGDPGLVSAYGAGLEGGV-TGSPAEFIVNTSNAGAGALSVTIDGP--SKVKMDCQECPEG 2246
             GD     A G G+   V TG    F+V+   AG G ++ T+  P  ++ + D  E  +G
Sbjct: 1612 -GDASKCLATGPGIASTVKTGEEVGFVVDAKTAGKGKVTCTVLTPDGTEAEADVIENEDG 1670

Query: 2247 -YRVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVT 2351
             Y + YT   PG+Y+I +++GG   I  SPF   VT
Sbjct: 1671 TYDIFYTAAKPGTYVIYVRFGG-VDIPNSPFTVMVT 1705



 Score =  296 bits (758), Expect = 7e-80
 Identities = 240/890 (26%), Positives = 386/890 (43%), Gaps = 47/890 (5%)
 Frame = +3

Query: 201  KGEITGEVRMPSGKVAQPAIT--DNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQF 374
            +G++   V  P G   +  +T   +K+ T +V Y P   GLH++ + +   HI  SP + 
Sbjct: 286  QGDVMVFVEDPEGNKEEALVTPDSDKNKTYSVEYLPKVTGLHKVTVLFAGQHISKSPFEV 345

Query: 375  YVDYV--NCGHVTAYGPGL--SHGVVNKPAVFTVNTKDAGEGGLSLAIEGP---SKAEIS 533
             VD    +   VTA GPGL  +  + NKP  F + T  AG G + + +E P   +  E+ 
Sbjct: 346  NVDKAQGDASKVTAKGPGLEVASNIANKPTYFDIYTAGAGVGDIGVEVEDPQGKNTVELL 405

Query: 534  CTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARV----------TGDDSMRMS 683
              D  +      Y P+ PG + + V +    IP SPF  +V               ++  
Sbjct: 406  VEDRGNQVYRCVYKPMQPGPHVVKVSFAGDTIPKSPFVVQVGEACNPNACRASGRGLQPK 465

Query: 684  HLKVGSAADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLV 863
             +++   AD  ++        L  T+  P G EE    K  ++G     + P   G++ V
Sbjct: 466  GIRIRETADFKVDTKAAGSGELGVTIKGPKGLEELVKQKGFQDGVYAFEYYPSTQGKYSV 525

Query: 864  HVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEGHTFEPAEFIIDTRDAGYGGLS 1043
             +   G H+  SP  V +         +VR  G GLH G     A+F++++  +  G L 
Sbjct: 526  SITWGGHHIQKSPFEVQVGPE--AGMQKVRAWGPGLHGGIVGRSADFVVESIGSEVGSLG 583

Query: 1044 LSIEGPSKVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKV-TGEGRV 1220
             +IEGPS+  I  +D  DG+C V Y P EPG Y ++I   D+ +  SPF   +    G  
Sbjct: 584  FAIEGPSQAKIEYDDQNDGSCDVKYWPKEPGEYAVHIMCDDEDIKDSPFMAYIHPASGDY 643

Query: 1221 KESITRRQ---RAPSVANVGSHCDLSLKIPEISIQDMTAQVTSPSGKSHEAEIVEGENHT 1391
               + +        S   V +  + ++   +     +        G+  + ++    + T
Sbjct: 644  NPDLVQAYGPGLEKSGCIVNNLAEFTVDPKDAGKAPLKIFAQDGDGQPIDIQMKSRMDGT 703

Query: 1392 YCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAH--KVRAGGPGLERA--EA 1559
            Y   + P +   HT++V + G ++P SP++ ++G     G+H  KV+  GPG+ER+  +A
Sbjct: 704  YACSYTPVKAIKHTIAVVWGGVNIPHSPYRVSIGQ----GSHPQKVKVFGPGVERSGLKA 759

Query: 1560 GVPAEFSIWTREAGAGGLAIAVE------GPSKAEISFE--DRKDGSCGVAYVVQEPGDY 1715
              P  F++   EAG G +++ ++         + ++ F+     + +  V YV    G Y
Sbjct: 760  HEPTHFTVDCTEAGEGDVSVGIKCDARVLSDEEEDVDFDIIHNANDTFTVKYVPPAAGRY 819

Query: 1716 EVSVKFNEEHIPDSPFVVPVASPSGDARRLTVS--SLQESGLKVNQPASFAVSLNGA-KG 1886
             + V F  + IP SPF V V  PS DA ++      L ++G++  +P  F V   GA K 
Sbjct: 820  TIKVLFASQEIPTSPFRVKV-DPSHDASKVKAEGPGLSKAGVENGKPTHFTVYTKGAGKA 878

Query: 1887 AIDAKVHS--PSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRV 2060
             ++ +  S  P  A+++  + +     + V++ P + G   + V + G  IP SPF + V
Sbjct: 879  PLNVQFSSPGPGDAVKDLDIIDNYDYSHTVKYTPTQQGNMQVLVTYGGDPIPKSPFTVGV 938

Query: 2061 GEPGHGGDPGLVSAYGAGLEGGV-TGSPAEFIVNTSNAGA-GALSVTIDGPSKVKMDCQE 2234
              P       L      GLE  V  G   EF V+T  AG  G L VTI  PS+  + C  
Sbjct: 939  AAP-----LDLSRIKINGLENRVEVGKDQEFAVDTRGAGGQGKLDVTILSPSRKVVPCLV 993

Query: 2235 CP----EGYRVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSVF 2402
             P    EG    + P   G Y I + Y G + + GSP+    +                 
Sbjct: 994  APMAGREGSTAKFIPREEGLYAIDLTYDG-HPVPGSPYVVEAS----------------- 1035

Query: 2403 VDSLTKTXXXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKAGNNMLLVGV 2582
                                   +KV A G GL    VG+   FT+D   AG   L + V
Sbjct: 1036 ------------------LPPDPTKVKAHGPGLRGGLVGKPAEFTIDTKGAGTGGLGLTV 1077

Query: 2583 HGPRTPCE-EILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYR 2729
             G   PCE +I     G    SVSYL    GEY + + + + HIPGSP++
Sbjct: 1078 EG---PCEAKIECSDNGDGTCSVSYLPTKPGEYFVNILFEEVHIPGSPFK 1124



 Score =  293 bits (751), Expect = 5e-79
 Identities = 253/874 (28%), Positives = 399/874 (45%), Gaps = 52/874 (5%)
 Frame = +3

Query: 273  DGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFYVDYVNCGH-VTAYGPGLSHGVV--N 443
            DGT    Y P +A  H + + +  ++IP SP +  +   +    V  +GPG+    +  +
Sbjct: 701  DGTYACSYTPVKAIKHTIAVVWGGVNIPHSPYRVSIGQGSHPQKVKVFGPGVERSGLKAH 760

Query: 444  KPAVFTVNTKDAGEGGLSLAIEGPSKA--------EISCTDNQDGTCSVSYLPVLPGDYS 599
            +P  FTV+  +AGEG +S+ I+  ++         +     N + T +V Y+P   G Y+
Sbjct: 761  EPTHFTVDCTEAGEGDVSVGIKCDARVLSDEEEDVDFDIIHNANDTFTVKYVPPAAGRYT 820

Query: 600  ILVKYNEQHIPGSPFTARV------------------TGDDSMRMSHLKVGS--AADIPI 719
            I V +  Q IP SPF  +V                   G ++ + +H  V +  A   P+
Sbjct: 821  IKVLFASQEIPTSPFRVKVDPSHDASKVKAEGPGLSKAGVENGKPTHFTVYTKGAGKAPL 880

Query: 720  NISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNGQHVASS 899
            N+  +          P    ++  ++      H  + + P + G   V V   G  +  S
Sbjct: 881  NVQFSSPG-------PGDAVKDLDIIDNYDYSHT-VKYTPTQQGNMQVLVTYGGDPIPKS 932

Query: 900  PIPVVISQSEIGDASRVRVSGRGLHEGHTFEPAEFIIDTRDAG-YGGLSLSIEGPSKVDI 1076
            P  V ++     D SR++++G   +     +  EF +DTR AG  G L ++I  PS+  +
Sbjct: 933  PFTVGVAAPL--DLSRIKINGLE-NRVEVGKDQEFAVDTRGAGGQGKLDVTILSPSRKVV 989

Query: 1077 NT-----EDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTGEGRVKESITR- 1238
                      E  T +  + P E G Y I++ +    VPGSP+ V    E  +    T+ 
Sbjct: 990  PCLVAPMAGREGSTAK--FIPREEGLYAIDLTYDGHPVPGSPYVV----EASLPPDPTKV 1043

Query: 1239 RQRAPSVAN--VGSHCDLSLKIPEISIQDMTAQVTSPSGKSHEAEIVEGENH--TYCIRF 1406
            +   P +    VG   + ++         +   V  P     EA+I   +N   T  + +
Sbjct: 1044 KAHGPGLRGGLVGKPAEFTIDTKGAGTGGLGLTVEGPC----EAKIECSDNGDGTCSVSY 1099

Query: 1407 VPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLERAEAGVPAEFSIW 1586
            +P + G + V++ ++  H+PGSPF+  +    +    KV A GPGLE  + G P   S+ 
Sbjct: 1100 LPTKPGEYFVNILFEEVHIPGSPFKADIEMPFDPS--KVVASGPGLEHGKVGEPGLLSVD 1157

Query: 1587 TREAGAG--GLAIAVEGPSKAEISFEDRKDGSCGVAYVVQEPGDYEVSVKFNEEHIPDSP 1760
              EAG G  GL    +  +KAE+  E+ KDG+  V YV    G Y +++K+  E +P  P
Sbjct: 1158 CSEAGPGTLGLEAVSDSGAKAEVCIENNKDGTYAVTYVPLTAGMYTLTMKYGGELVPHFP 1217

Query: 1761 FVVPVASPSGDARRLTVSSLQESGLKVNQPASFAVSLNGAK------GAIDAKVHSPSGA 1922
              V V  P+ D  R+ V      G  V + A+   +++           I A + +PSGA
Sbjct: 1218 TRVKV-EPAVDTSRVKVFGPGIEGKDVFREATTDFTVDSRPLTQVGGDHIKAHIANPSGA 1276

Query: 1923 LEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPGLVSA 2102
              EC+VT+     Y V + P E G+++++V ++   +P SPFK+ V E   G  P  V A
Sbjct: 1277 STECFVTDNADGTYQVEYTPFEKGLHVVEVTYDDVPVPNSPFKVAVTE---GCQPSRVQA 1333

Query: 2103 YGAGLEGGVTGSPAEFIVNTSNAGAGALSVTIDGPSKVKMDCQECPEGY-RVTYTPMAPG 2279
             G GL+   T  P  F V T  AG G L +T++GPS+ K++C++  +G     Y P APG
Sbjct: 1334 QGPGLKEAFTNKPNVFTVVTRGAGIGGLGITVEGPSESKINCRDNKDGSCSAEYVPFAPG 1393

Query: 2280 SYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSVFVDSLTKTXXXXXXXXXXXX 2459
             Y ++I YGG  HI GSPF+  V          + + S V                    
Sbjct: 1394 DYDVNITYGGA-HIPGSPFRVPVK--------DVVDPSKV-------------------- 1424

Query: 2460 XXXXSKVLAKGLGLS-KAYVGQKGSFTVDCSKAGNNMLLVGVHGPRTPCEEILVKHVGSR 2636
                 K++  GLG   +A V Q  SFTVD SKAG   L V V GPR   E + V   G  
Sbjct: 1425 -----KIVGPGLGSGVRARVLQ--SFTVDSSKAGLAPLEVRVMGPRGLVEPVNVVDNGDG 1477

Query: 2637 LYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLV 2738
             ++V+Y    +G Y + VK+ DE IP SP++V V
Sbjct: 1478 THTVTYTPSQEGPYMVSVKYADEEIPRSPFKVKV 1511



 Score =  277 bits (709), Expect = 4e-74
 Identities = 238/885 (26%), Positives = 379/885 (42%), Gaps = 40/885 (4%)
 Frame = +3

Query: 204  GEITGEVRMPSGKVAQPAITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFYVD 383
            GE+   ++ P G          +DG     Y PS  G + + I +   HI  SP +  V 
Sbjct: 485  GELGVTIKGPKGLEELVKQKGFQDGVYAFEYYPSTQGKYSVSITWGGHHIQKSPFEVQVG 544

Query: 384  -YVNCGHVTAYGPGLSHGVVNKPAVFTVNTKDAGEGGLSLAIEGPSKAEISCTDNQDGTC 560
                   V A+GPGL  G+V + A F V +  +  G L  AIEGPS+A+I   D  DG+C
Sbjct: 545  PEAGMQKVRAWGPGLHGGIVGRSADFVVESIGSEVGSLGFAIEGPSQAKIEYDDQNDGSC 604

Query: 561  SVSYLPVLPGDYSILVKYNEQHIPGSPFTARV---TGD----------DSMRMSHLKVGS 701
             V Y P  PG+Y++ +  +++ I  SPF A +   +GD            +  S   V +
Sbjct: 605  DVKYWPKEPGEYAVHIMCDDEDIKDSPFMAYIHPASGDYNPDLVQAYGPGLEKSGCIVNN 664

Query: 702  AADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNG 881
             A+  ++  +   + L        G+     +K   +G    S+ P +  +H + V   G
Sbjct: 665  LAEFTVDPKDAGKAPLKIFAQDGDGQPIDIQMKSRMDGTYACSYTPVKAIKHTIAVVWGG 724

Query: 882  QHVASSPIPVVISQSEIGDASRVRVSGRGLHEG--HTFEPAEFIIDTRDAGYGGLSLSIE 1055
             ++  SP  V I Q       +V+V G G+        EP  F +D  +AG G +S+ I+
Sbjct: 725  VNIPHSPYRVSIGQG--SHPQKVKVFGPGVERSGLKAHEPTHFTVDCTEAGEGDVSVGIK 782

Query: 1056 GPSKVDINTEDLED--------GTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVT-- 1205
              ++V  + E+  D         T  V Y P   G Y I + FA Q +P SPF VKV   
Sbjct: 783  CDARVLSDEEEDVDFDIIHNANDTFTVKYVPPAAGRYTIKVLFASQEIPTSPFRVKVDPS 842

Query: 1206 -GEGRVKESITRRQRAPSVANVGSHCDLSLKIPEISIQDMTAQVTSPSGKSHEAEIVEGE 1382
                +VK       +A       +H  +  K    +  ++      P     + +I++  
Sbjct: 843  HDASKVKAEGPGLSKAGVENGKPTHFTVYTKGAGKAPLNVQFSSPGPGDAVKDLDIIDNY 902

Query: 1383 NHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLE-RAEA 1559
            ++++ +++ P + G   V V Y G  +P SP  FTVG        +++    GLE R E 
Sbjct: 903  DYSHTVKYTPTQQGNMQVLVTYGGDPIPKSP--FTVGVAAPLDLSRIKIN--GLENRVEV 958

Query: 1560 GVPAEFSIWTREAGA-GGLAIAVEGPSK----AEISFEDRKDGSCGVAYVVQEPGDYEVS 1724
            G   EF++ TR AG  G L + +  PS+      ++    ++GS    ++ +E G Y + 
Sbjct: 959  GKDQEFAVDTRGAGGQGKLDVTILSPSRKVVPCLVAPMAGREGST-AKFIPREEGLYAID 1017

Query: 1725 VKFNEEHIPDSPFVVPVASPSGDARRLTVSSLQESGLKVNQPASFAVSLNGA-KGAIDAK 1901
            + ++   +P SP+VV  + P  D  ++        G  V +PA F +   GA  G +   
Sbjct: 1018 LTYDGHPVPGSPYVVEASLPP-DPTKVKAHGPGLRGGLVGKPAEFTIDTKGAGTGGLGLT 1076

Query: 1902 VHSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGG 2081
            V  P  A  EC  ++      +V ++P + G Y +++ F   HIPGSPFK  +  P    
Sbjct: 1077 VEGPCEAKIEC--SDNGDGTCSVSYLPTKPGEYFVNILFEEVHIPGSPFKADIEMP---F 1131

Query: 2082 DPGLVSAYGAGLEGGVTGSPAEFIVNTSNAGAGALSV--TIDGPSKVKMDCQECPEG-YR 2252
            DP  V A G GLE G  G P    V+ S AG G L +    D  +K ++  +   +G Y 
Sbjct: 1132 DPSKVVASGPGLEHGKVGEPGLLSVDCSEAGPGTLGLEAVSDSGAKAEVCIENNKDGTYA 1191

Query: 2253 VTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSVFVDSLTKTXXX 2432
            VTY P+  G Y +++KYGG   +   P + +V            +TS V           
Sbjct: 1192 VTYVPLTAGMYTLTMKYGGEL-VPHFPTRVKV--------EPAVDTSRV----------- 1231

Query: 2433 XXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVD---CSKAGNNMLLVGVHGPRTPC 2603
                          KV   G+     +      FTVD    ++ G + +   +  P    
Sbjct: 1232 --------------KVFGPGIEGKDVFREATTDFTVDSRPLTQVGGDHIKAHIANPSGAS 1277

Query: 2604 EEILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLV 2738
             E  V       Y V Y   +KG + + V + D  +P SP++V V
Sbjct: 1278 TECFVTDNADGTYQVEYTPFEKGLHVVEVTYDDVPVPNSPFKVAV 1322



 Score =  252 bits (643), Expect = 2e-66
 Identities = 201/687 (29%), Positives = 308/687 (44%), Gaps = 29/687 (4%)
 Frame = +3

Query: 759  VVPPSGREEPCLLK--RLRNGHVGISFVPKETGEHLVHVKKNGQHVASSPIPVVISQSEI 932
            V  P G +E  L+     +N    + ++PK TG H V V   GQH++ SP  V + +++ 
Sbjct: 293  VEDPEGNKEEALVTPDSDKNKTYSVEYLPKVTGLHKVTVLFAGQHISKSPFEVNVDKAQ- 351

Query: 933  GDASRVRVSGRGLHEGHTF--EPAEFIIDTRDAGYGGLSLSIEGP---SKVDINTEDLED 1097
            GDAS+V   G GL        +P  F I T  AG G + + +E P   + V++  ED  +
Sbjct: 352  GDASKVTAKGPGLEVASNIANKPTYFDIYTAGAGVGDIGVEVEDPQGKNTVELLVEDRGN 411

Query: 1098 GTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTGEGRVKESITRRQRA--PSVANVG 1271
               R  Y P +PG +++ + FA   +P SPF V+V GE     +     R   P    + 
Sbjct: 412  QVYRCVYKPMQPGPHVVKVSFAGDTIPKSPFVVQV-GEACNPNACRASGRGLQPKGIRIR 470

Query: 1272 SHCDLSLKIPEISIQDMTAQVTSPSGKSHEAEIVEGENHTYCIRFVPAEMGMHTVSVKYK 1451
               D  +        ++   +  P G     +    ++  Y   + P+  G ++VS+ + 
Sbjct: 471  ETADFKVDTKAAGSGELGVTIKGPKGLEELVKQKGFQDGVYAFEYYPSTQGKYSVSITWG 530

Query: 1452 GQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLERAEAGVPAEFSIWTREAGAGGLAIAVEG 1631
            G H+  SPF+  VGP  E G  KVRA GPGL     G  A+F + +  +  G L  A+EG
Sbjct: 531  GHHIQKSPFEVQVGP--EAGMQKVRAWGPGLHGGIVGRSADFVVESIGSEVGSLGFAIEG 588

Query: 1632 PSKAEISFEDRKDGSCGVAYVVQEPGDYEVSVKFNEEHIPDSPFVVPVASPSGDARRLTV 1811
            PS+A+I ++D+ DGSC V Y  +EPG+Y V +  ++E I DSPF+  +   SGD     V
Sbjct: 589  PSQAKIEYDDQNDGSCDVKYWPKEPGEYAVHIMCDDEDIKDSPFMAYIHPASGDYNPDLV 648

Query: 1812 SS----LQESGLKVNQPASFAVSLNGA-KGAIDAKVHSPSGALEECYVTEIDQDKYAVRF 1976
             +    L++SG  VN  A F V    A K  +        G   +  +       YA  +
Sbjct: 649  QAYGPGLEKSGCIVNNLAEFTVDPKDAGKAPLKIFAQDGDGQPIDIQMKSRMDGTYACSY 708

Query: 1977 IPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPGLVSAYGAGLE--GGVTGSPAEF 2150
             P +   + I V + G +IP SP+++ +G+  H   P  V  +G G+E  G     P  F
Sbjct: 709  TPVKAIKHTIAVVWGGVNIPHSPYRVSIGQGSH---PQKVKVFGPGVERSGLKAHEPTHF 765

Query: 2151 IVNTSNAGAGALSVTIDGPSKVKMDCQE---------CPEGYRVTYTPMAPGSYLISIKY 2303
             V+ + AG G +SV I   ++V  D +E           + + V Y P A G Y I + +
Sbjct: 766  TVDCTEAGEGDVSVGIKCDARVLSDEEEDVDFDIIHNANDTFTVKYVPPAAGRYTIKVLF 825

Query: 2304 GGPYHIGGSPFKARVTGHRLVSNHSLHETSSVFVDSLTKTXXXXXXXXXXXXXXXXSKVL 2483
                 I  SPF+ +V       +H                                SKV 
Sbjct: 826  AS-QEIPTSPFRVKVD-----PSHD------------------------------ASKVK 849

Query: 2484 AKGLGLSKAYV--GQKGSFTVDCSKAGNNMLLV--GVHGPRTPCEEILVKHVGSRLYSVS 2651
            A+G GLSKA V  G+   FTV    AG   L V     GP    +++ +       ++V 
Sbjct: 850  AEGPGLSKAGVENGKPTHFTVYTKGAGKAPLNVQFSSPGPGDAVKDLDIIDNYDYSHTVK 909

Query: 2652 YLLKDKGEYTLVVKWGDEHIPGSPYRV 2732
            Y    +G   ++V +G + IP SP+ V
Sbjct: 910  YTPTQQGNMQVLVTYGGDPIPKSPFTV 936



 Score =  222 bits (566), Expect = 1e-57
 Identities = 229/840 (27%), Positives = 359/840 (42%), Gaps = 47/840 (5%)
 Frame = +3

Query: 354  PGSPLQFYVDYVNCGHVTAYGPGL--SHGVVNKPAVFTVNTKDAGEGGLSLAIEGP--SK 521
            PG+PL+     +N     AYG G+  +  +V +PA FTV+T  AG+G + + +E P  +K
Sbjct: 244  PGAPLK---PKLNPKKARAYGRGIEPTGNMVKQPAKFTVDTISAGQGDVMVFVEDPEGNK 300

Query: 522  AEISCTDNQD--GTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARVTGDDSMRMSHLKV 695
             E   T + D   T SV YLP + G + + V +  QHI  SPF   V             
Sbjct: 301  EEALVTPDSDKNKTYSVEYLPKVTGLHKVTVLFAGQHISKSPFEVNVDKAQGDASKVTAK 360

Query: 696  GSAADIPINISE--TDLSLLTA---------TVVPPSGREEPCLLKRLRNGHV-GISFVP 839
            G   ++  NI+   T   + TA          V  P G+    LL   R   V    + P
Sbjct: 361  GPGLEVASNIANKPTYFDIYTAGAGVGDIGVEVEDPQGKNTVELLVEDRGNQVYRCVYKP 420

Query: 840  KETGEHLVHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEG--HTFEPAEFIID 1013
             + G H+V V   G  +  SP   V+   E  + +  R SGRGL        E A+F +D
Sbjct: 421  MQPGPHVVKVSFAGDTIPKSPF--VVQVGEACNPNACRASGRGLQPKGIRIRETADFKVD 478

Query: 1014 TRDAGYGGLSLSIEGPSKVD--INTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSP 1187
            T+ AG G L ++I+GP  ++  +  +  +DG     Y P+  G Y ++I +   H+  SP
Sbjct: 479  TKAAGSGELGVTIKGPKGLEELVKQKGFQDGVYAFEYYPSTQGKYSVSITWGGHHIQKSP 538

Query: 1188 FSVKVTGEGRVKESITRRQRAPSVAN--VGSHCDLSLKIPEISIQDMTAQVTSPSGKSHE 1361
            F V+V  E  +++    R   P +    VG   D  ++     +  +   +  PS    E
Sbjct: 539  FEVQVGPEAGMQKV---RAWGPGLHGGIVGRSADFVVESIGSEVGSLGFAIEGPSQAKIE 595

Query: 1362 AEIVEGENHTYC-IRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPL-GEGGAHKVRAGG 1535
                + +N   C +++ P E G + V +    + +  SPF   + P  G+     V+A G
Sbjct: 596  ---YDDQNDGSCDVKYWPKEPGEYAVHIMCDDEDIKDSPFMAYIHPASGDYNPDLVQAYG 652

Query: 1536 PGLERAEAGVP--AEFSIWTREAGAGGLAI-AVEGPSK-AEISFEDRKDGSCGVAYVVQE 1703
            PGLE++   V   AEF++  ++AG   L I A +G  +  +I  + R DG+   +Y   +
Sbjct: 653  PGLEKSGCIVNNLAEFTVDPKDAGKAPLKIFAQDGDGQPIDIQMKSRMDGTYACSYTPVK 712

Query: 1704 PGDYEVSVKFNEEHIPDSPFVVPVASPSGDAR-RLTVSSLQESGLKVNQPASFAVSLNGA 1880
               + ++V +   +IP SP+ V +   S   + ++    ++ SGLK ++P  F V    A
Sbjct: 713  AIKHTIAVVWGGVNIPHSPYRVSIGQGSHPQKVKVFGPGVERSGLKAHEPTHFTVDCTEA 772

Query: 1881 -KGAI------DAKVHSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPG 2039
             +G +      DA+V S      +  +     D + V+++P   G Y I V F    IP 
Sbjct: 773  GEGDVSVGIKCDARVLSDEEEDVDFDIIHNANDTFTVKYVPPAAGRYTIKVLFASQEIPT 832

Query: 2040 SPFKIRVGEPGHGGDPGLVSAYGAGLE--GGVTGSPAEFIVNTSNAGAGALSVTID--GP 2207
            SPF+++V +P H  D   V A G GL   G   G P  F V T  AG   L+V     GP
Sbjct: 833  SPFRVKV-DPSH--DASKVKAEGPGLSKAGVENGKPTHFTVYTKGAGKAPLNVQFSSPGP 889

Query: 2208 SKVKMD---CQECPEGYRVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHS 2378
                 D          + V YTP   G+  + + YGG   I  SPF   V          
Sbjct: 890  GDAVKDLDIIDNYDYSHTVKYTPTQQGNMQVLVTYGGD-PIPKSPFTVGVAA-------- 940

Query: 2379 LHETSSVFVDSLTKTXXXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKA- 2555
                                           S++   GL  ++  VG+   F VD   A 
Sbjct: 941  ---------------------------PLDLSRIKINGLE-NRVEVGKDQEFAVDTRGAG 972

Query: 2556 GNNMLLVGVHGPRTPCEEILVKHVGSRLYSVS-YLLKDKGEYTLVVKWGDEHIPGSPYRV 2732
            G   L V +  P       LV  +  R  S + ++ +++G Y + + +    +PGSPY V
Sbjct: 973  GQGKLDVTILSPSRKVVPCLVAPMAGREGSTAKFIPREEGLYAIDLTYDGHPVPGSPYVV 1032


>ref|XP_002702810.1| PREDICTED: filamin B, beta [Bos taurus].
          Length = 2591

 Score = 1308 bits (3385), Expect = 0.0
 Identities = 625/872 (71%), Positives = 741/872 (84%)
 Frame = +3

Query: 126  PLVGVNGLDVTSLRPFDLVIPFTIKKGEITGEVRMPSGKVAQPAITDNKDGTVTVRYAPS 305
            P+  +NGL     +PFDLVIPF ++KGEITGEV MPSGK A+P I DNKDGTVTVRYAP+
Sbjct: 1724 PVSNMNGL---GFKPFDLVIPFAVRKGEITGEVHMPSGKTAKPEIVDNKDGTVTVRYAPT 1780

Query: 306  EAGLHEMDIRYDNMHIPGSPLQFYVDYVNCGHVTAYGPGLSHGVVNKPAVFTVNTKDAGE 485
            E GLHEM I+Y   HIP SPLQFYV+Y N G V+AYGPGL +GV NK A FT+ T+DAGE
Sbjct: 1781 EVGLHEMHIKYMGSHIPESPLQFYVNYPNSGSVSAYGPGLVYGVANKTATFTIVTEDAGE 1840

Query: 486  GGLSLAIEGPSKAEISCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARVTGD 665
            GGL LAIEGPSKAEISC DN+DGTC+V+YLP LPGDYSILVKYN++HIPGSPFTA++T D
Sbjct: 1841 GGLDLAIEGPSKAEISCIDNKDGTCTVTYLPTLPGDYSILVKYNDKHIPGSPFTAKIT-D 1899

Query: 666  DSMRMSHLKVGSAADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKE 845
            DS R S +K+GSAAD  ++ISETDLS LTA++  PSGR+EPCLLKRL N H+GISF+P+E
Sbjct: 1900 DSRRCSQVKLGSAADFLLDISETDLSTLTASIKAPSGRDEPCLLKRLPNNHIGISFIPRE 1959

Query: 846  TGEHLVHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEGHTFEPAEFIIDTRDA 1025
             GEHLV +KKNG HVA+SP+ +++ QSEIGDA R +V GRGL EG TFE ++FI+DTRDA
Sbjct: 1960 VGEHLVSIKKNGNHVANSPVSIMVVQSEIGDARRAKVYGRGLSEGRTFEMSDFIVDTRDA 2019

Query: 1026 GYGGLSLSIEGPSKVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVT 1205
            GYGG+SL++EGPSKVDI TEDLEDGTC+V+Y PT PG YI++ KFAD+HVPGSPF+VK++
Sbjct: 2020 GYGGISLAVEGPSKVDIQTEDLEDGTCKVSYFPTVPGVYIVSTKFADEHVPGSPFTVKIS 2079

Query: 1206 GEGRVKESITRRQRAPSVANVGSHCDLSLKIPEISIQDMTAQVTSPSGKSHEAEIVEGEN 1385
            GEGRVKESITR  RAPSVA VGS CDL+LKIPEI   DM+A VTSPSG+  EAEIV    
Sbjct: 2080 GEGRVKESITRTSRAPSVATVGSICDLNLKIPEIDSSDMSAHVTSPSGRVTEAEIVPVGK 2139

Query: 1386 HTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLERAEAGV 1565
            +++C+RFVP EMG+HTVSVKY+GQHV GSPFQFTVGPLGEGGAHKVRAGGPGLER EAGV
Sbjct: 2140 NSHCVRFVPQEMGVHTVSVKYRGQHVTGSPFQFTVGPLGEGGAHKVRAGGPGLERGEAGV 2199

Query: 1566 PAEFSIWTREAGAGGLAIAVEGPSKAEISFEDRKDGSCGVAYVVQEPGDYEVSVKFNEEH 1745
            PAEFSIWTREAGAGGL+IAVEGPSKAEI+F+D K+GSCGV+Y+ QEPG+YEVS+KFN+EH
Sbjct: 2200 PAEFSIWTREAGAGGLSIAVEGPSKAEITFDDHKNGSCGVSYIAQEPGNYEVSIKFNDEH 2259

Query: 1746 IPDSPFVVPVASPSGDARRLTVSSLQESGLKVNQPASFAVSLNGAKGAIDAKVHSPSGAL 1925
            IP+SP+VVPV +PS DARRLTV SLQESGLKVNQPASFA+ LNGAKG IDAKVHSPSGA+
Sbjct: 2260 IPESPYVVPVIAPSDDARRLTVLSLQESGLKVNQPASFAIRLNGAKGKIDAKVHSPSGAV 2319

Query: 1926 EECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPGLVSAY 2105
            EEC+V+E++ DKYAVRFIP ENG++ IDVKFNG+H+ GSPFK+RVGEPG  G+P LVSAY
Sbjct: 2320 EECHVSELEPDKYAVRFIPHENGIHTIDVKFNGSHVVGSPFKVRVGEPGQAGNPALVSAY 2379

Query: 2106 GAGLEGGVTGSPAEFIVNTSNAGAGALSVTIDGPSKVKMDCQECPEGYRVTYTPMAPGSY 2285
            GAGLEGG TG  +EF +NT+ AG G LSVTI+GPSKVKMDCQE PEGY+V YTPMAPG+Y
Sbjct: 2380 GAGLEGGSTGIQSEFFINTTRAGPGTLSVTIEGPSKVKMDCQETPEGYKVMYTPMAPGNY 2439

Query: 2286 LISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSVFVDSLTKTXXXXXXXXXXXXXX 2465
            LI +KYGGP HI GSPFKA+VTG RLVS  S +ETSS+ V+S+T++              
Sbjct: 2440 LIGVKYGGPNHIVGSPFKAKVTGQRLVSPGSANETSSILVESVTRSSTETCYSAIPKASS 2499

Query: 2466 XXSKVLAKGLGLSKAYVGQKGSFTVDCSKAGNNMLLVGVHGPRTPCEEILVKHVGSRLYS 2645
              SKV +KG GLSKA++GQK SF VDCSKAG+NMLL+GVHGP TPCEE+ +KHVG++ Y+
Sbjct: 2500 DASKVTSKGAGLSKAFLGQKSSFLVDCSKAGSNMLLIGVHGPTTPCEEVSMKHVGNQQYN 2559

Query: 2646 VSYLLKDKGEYTLVVKWGDEHIPGSPYRVLVP 2741
            V+Y++K++G+Y L VKWG+EHIPGSP+ V VP
Sbjct: 2560 VTYVVKERGDYVLAVKWGEEHIPGSPFHVTVP 2591



 Score =  436 bits (1120), Expect = e-122
 Identities = 287/882 (32%), Positives = 422/882 (47%), Gaps = 25/882 (2%)
 Frame = +3

Query: 168  PFDLVIPFTIK-----KGEITGEVRMPSGKVAQPAITDNKDGTVTVRYAPSEAGLHEMDI 332
            P  L + F I      +G +  ++    GK  +  + DNKDGT  V Y P + G + + +
Sbjct: 1533 PASLPVEFAIDARDAGEGLLAVQITDQEGKPKRAIVHDNKDGTYAVTYIPDKTGRYMIGV 1592

Query: 333  RYDNMHIPGSPLQFYVDYV-NCGHVTAYGPGLSHGVVNKPAV-FTVNTKDAGEGGLSLAI 506
             Y    IP SP +       +     A GPG++  V     V F V+ K AG+G ++  +
Sbjct: 1593 TYGGDDIPLSPYRIRATQTGDASKCLATGPGIASTVKTGEEVGFVVDAKTAGKGKVTCTV 1652

Query: 507  EGP--SKAEISCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARVTGDDSMRM 680
              P  ++AE    +N+DGT  + Y    PG Y I V++    IP SPFT   T  +   +
Sbjct: 1653 LTPDGTEAEADVIENEDGTYDIFYTAAKPGTYVIYVRFGGVDIPNSPFTVMATDGEVAAV 1712

Query: 681  SHLKVGSAADIPIN------ISETDLSL--------LTATVVPPSGREEPCLLKRLRNGH 818
              + V   A +P++          DL +        +T  V  PSG+     +   ++G 
Sbjct: 1713 KEVPVTEEAYVPVSNMNGLGFKPFDLVIPFAVRKGEITGEVHMPSGKTAKPEIVDNKDGT 1772

Query: 819  VGISFVPKETGEHLVHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEGHTFEPA 998
            V + + P E G H +H+K  G H+  SP+   ++    G  S     G GL  G   + A
Sbjct: 1773 VTVRYAPTEVGLHEMHIKYMGSHIPESPLQFYVNYPNSGSVS---AYGPGLVYGVANKTA 1829

Query: 999  EFIIDTRDAGYGGLSLSIEGPSKVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVP 1178
             F I T DAG GGL L+IEGPSK +I+  D +DGTC VTY PT PG+Y I +K+ D+H+P
Sbjct: 1830 TFTIVTEDAGEGGLDLAIEGPSKAEISCIDNKDGTCTVTYLPTLPGDYSILVKYNDKHIP 1889

Query: 1179 GSPFSVKVTGEGRVKESITRRQRAPSVANVGSHCDLSLKIPEISIQDMTAQVTSPSGKSH 1358
            GSPF+ K+T +           R  S   +GS  D  L I E  +  +TA + +PSG+  
Sbjct: 1890 GSPFTAKITDD----------SRRCSQVKLGSAADFLLDISETDLSTLTASIKAPSGRDE 1939

Query: 1359 EAEIVEGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGP 1538
               +    N+   I F+P E+G H VS+K  G HV  SP    V     G A + +  G 
Sbjct: 1940 PCLLKRLPNNHIGISFIPREVGEHLVSIKKNGNHVANSPVSIMVVQSEIGDARRAKVYGR 1999

Query: 1539 GLERAEAGVPAEFSIWTREAGAGGLAIAVEGPSKAEISFEDRKDGSCGVAYVVQEPGDYE 1718
            GL        ++F + TR+AG GG+++AVEGPSK +I  ED +DG+C V+Y    PG Y 
Sbjct: 2000 GLSEGRTFEMSDFIVDTRDAGYGGISLAVEGPSKVDIQTEDLEDGTCKVSYFPTVPGVYI 2059

Query: 1719 VSVKFNEEHIPDSPFVVPVASPSGDARRLTVSSLQESGLKVNQPASFAVSLNGAKGA-ID 1895
            VS KF +EH+P SPF V ++        +T +S   S   V       + +     + + 
Sbjct: 2060 VSTKFADEHVPGSPFTVKISGEGRVKESITRTSRAPSVATVGSICDLNLKIPEIDSSDMS 2119

Query: 1896 AKVHSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGH 2075
            A V SPSG + E  +  + ++ + VRF+P+E GV+ + VK+ G H+ GSPF+  VG  G 
Sbjct: 2120 AHVTSPSGRVTEAEIVPVGKNSHCVRFVPQEMGVHTVSVKYRGQHVTGSPFQFTVGPLGE 2179

Query: 2076 GGDPGLVSAYGAGLEGGVTGSPAEFIVNTSNAGAGALSVTIDGPSKVKMDCQECPEG-YR 2252
            GG    V A G GLE G  G PAEF + T  AGAG LS+ ++GPSK ++   +   G   
Sbjct: 2180 GG-AHKVRAGGPGLERGEAGVPAEFSIWTREAGAGGLSIAVEGPSKAEITFDDHKNGSCG 2238

Query: 2253 VTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSVFVDSLTKTXXX 2432
            V+Y    PG+Y +SIK+    HI  SP+   V                            
Sbjct: 2239 VSYIAQEPGNYEVSIKFNDE-HIPESPYVVPVIA-------------------------- 2271

Query: 2433 XXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKAGNNMLLVGVHGPRTPCEEI 2612
                          ++    L  S   V Q  SF +  + A    +   VH P    EE 
Sbjct: 2272 --------PSDDARRLTVLSLQESGLKVNQPASFAIRLNGA-KGKIDAKVHSPSGAVEEC 2322

Query: 2613 LVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLV 2738
             V  +    Y+V ++  + G +T+ VK+   H+ GSP++V V
Sbjct: 2323 HVSELEPDKYAVRFIPHENGIHTIDVKFNGSHVVGSPFKVRV 2364



 Score =  333 bits (853), Expect = 7e-91
 Identities = 266/887 (29%), Positives = 408/887 (45%), Gaps = 41/887 (4%)
 Frame = +3

Query: 201  KGEITGEVRMPSGKVAQPAITD--NKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQF 374
            +G++   +  PS KV    +     ++G+ T ++ P E GL+ +D+ YD   +PGSP   
Sbjct: 974  QGKLDVTILSPSRKVVPCLVAPMAGREGS-TAKFIPREEGLYAIDLTYDGHPVPGSPYVV 1032

Query: 375  YVDYV-NCGHVTAYGPGLSHGVVNKPAVFTVNTKDAGEGGLSLAIEGPSKAEISCTDNQD 551
                  +   V A+GPGL  G+V KPA FT++TK AG GGL L +EGP +A+I C+DN D
Sbjct: 1033 EASLPPDPTKVKAHGPGLRGGLVGKPAEFTIDTKGAGTGGLGLTVEGPCEAKIECSDNGD 1092

Query: 552  GTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARV--------TGDDSMRMSHLKVGSAA 707
            GTCSVSYLP  PG+Y + + + E HIPGSPF A +               + H KVG   
Sbjct: 1093 GTCSVSYLPTKPGEYFVNILFEEVHIPGSPFKADIEMPFDPSKVVASGPGLEHGKVGEPG 1152

Query: 708  DIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNGQH 887
             + ++ SE     L    V  SG +    ++  ++G   +++VP   G + + +K  G+ 
Sbjct: 1153 LLSVDCSEAGPGTLGLEAVSDSGAKAEVCIENNKDGTYAVTYVPLTAGMYTLTMKYGGEL 1212

Query: 888  VASSPIPVVISQSEIGDASRVRVSGRGLHEGHTFEPA--EFIIDTR---DAGYGGLSLSI 1052
            V   P  V +  +   D SRV+V G G+     F  A  +F +D+R     G   +   I
Sbjct: 1213 VPHFPTRVKVEPAV--DTSRVKVFGPGIEGKDVFREATTDFTVDSRPLTQVGGDHIKAHI 1270

Query: 1053 EGPS--KVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVT------- 1205
              PS    +    D  DGT +V Y P E G +++ + + D  VP SPF V VT       
Sbjct: 1271 ANPSGASTECFVTDNADGTYQVEYTPFEKGLHVVEVTYDDVPVPNSPFKVAVTEGCQPSR 1330

Query: 1206 ----GEGRVKESITRRQRAPSVANVGSHCDLSLKIPEISIQDMTAQVTSPSGKSHEAEIV 1373
                G G +KE+ T +    +V   G+            I  +   V  PS    +    
Sbjct: 1331 VQAQGPG-LKEAFTNKPNVFTVVTRGA-----------GIGGLGITVEGPS--ESKINCR 1376

Query: 1374 EGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGL-ER 1550
            + ++ +    +VP   G + V++ Y G H+PGSPF+  V  + +    KV+  GPGL   
Sbjct: 1377 DNKDGSCSAEYVPFAPGDYDVNITYGGAHIPGSPFRVPVKDVVD--PSKVKIVGPGLGSG 1434

Query: 1551 AEAGVPAEFSIWTREAGAGGLAIAVEGPS--KAEISFEDRKDGSCGVAYVVQEPGDYEVS 1724
              A V   F++ + +AG   L + V GP      ++  D  DG+  V Y   + G Y VS
Sbjct: 1435 VRARVLQSFTVDSSKAGLAPLEVRVMGPRGLVEPVNVVDNGDGTHTVTYTPSQEGPYMVS 1494

Query: 1725 VKFNEEHIPDSPFVVPVASPSGDARRLTVS--SLQESGLKVNQPASFAVSLNGA-KGAID 1895
            VK+ +E IP SPF V V  P+ DA ++T S   L   G+  + P  FA+    A +G + 
Sbjct: 1495 VKYADEEIPRSPFKVKVL-PTYDASKVTASGPGLSTYGVPASLPVEFAIDARDAGEGLLA 1553

Query: 1896 AKVHSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGH 2075
             ++    G  +   V +     YAV +IP + G Y+I V + G  IP SP++IR  +   
Sbjct: 1554 VQITDQEGKPKRAIVHDNKDGTYAVTYIPDKTGRYMIGVTYGGDDIPLSPYRIRATQT-- 1611

Query: 2076 GGDPGLVSAYGAGLEGGV-TGSPAEFIVNTSNAGAGALSVTIDGP--SKVKMDCQECPEG 2246
             GD     A G G+   V TG    F+V+   AG G ++ T+  P  ++ + D  E  +G
Sbjct: 1612 -GDASKCLATGPGIASTVKTGEEVGFVVDAKTAGKGKVTCTVLTPDGTEAEADVIENEDG 1670

Query: 2247 -YRVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSVFVDSLTKT 2423
             Y + YT   PG+Y+I +++GG   I  SPF    T   + +   +  T   +V      
Sbjct: 1671 TYDIFYTAAKPGTYVIYVRFGG-VDIPNSPFTVMATDGEVAAVKEVPVTEEAYVPVSNMN 1729

Query: 2424 XXXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKAGNNMLLVGVHGP--RT 2597
                                 K   L   +  +KG  T +            VH P  +T
Sbjct: 1730 GLGF-----------------KPFDLVIPFAVRKGEITGE------------VHMPSGKT 1760

Query: 2598 PCEEILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLV 2738
               EI+    G+   +V Y   + G + + +K+   HIP SP +  V
Sbjct: 1761 AKPEIVDNKDGT--VTVRYAPTEVGLHEMHIKYMGSHIPESPLQFYV 1805



 Score =  296 bits (758), Expect = 7e-80
 Identities = 240/890 (26%), Positives = 386/890 (43%), Gaps = 47/890 (5%)
 Frame = +3

Query: 201  KGEITGEVRMPSGKVAQPAIT--DNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQF 374
            +G++   V  P G   +  +T   +K+ T +V Y P   GLH++ + +   HI  SP + 
Sbjct: 286  QGDVMVFVEDPEGNKEEALVTPDSDKNKTYSVEYLPKVTGLHKVTVLFAGQHISKSPFEV 345

Query: 375  YVDYV--NCGHVTAYGPGL--SHGVVNKPAVFTVNTKDAGEGGLSLAIEGP---SKAEIS 533
             VD    +   VTA GPGL  +  + NKP  F + T  AG G + + +E P   +  E+ 
Sbjct: 346  NVDKAQGDASKVTAKGPGLEVASNIANKPTYFDIYTAGAGVGDIGVEVEDPQGKNTVELL 405

Query: 534  CTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARV----------TGDDSMRMS 683
              D  +      Y P+ PG + + V +    IP SPF  +V               ++  
Sbjct: 406  VEDRGNQVYRCVYKPMQPGPHVVKVSFAGDTIPKSPFVVQVGEACNPNACRASGRGLQPK 465

Query: 684  HLKVGSAADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLV 863
             +++   AD  ++        L  T+  P G EE    K  ++G     + P   G++ V
Sbjct: 466  GIRIRETADFKVDTKAAGSGELGVTIKGPKGLEELVKQKGFQDGVYAFEYYPSTQGKYSV 525

Query: 864  HVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEGHTFEPAEFIIDTRDAGYGGLS 1043
             +   G H+  SP  V +         +VR  G GLH G     A+F++++  +  G L 
Sbjct: 526  SITWGGHHIQKSPFEVQVGPE--AGMQKVRAWGPGLHGGIVGRSADFVVESIGSEVGSLG 583

Query: 1044 LSIEGPSKVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKV-TGEGRV 1220
             +IEGPS+  I  +D  DG+C V Y P EPG Y ++I   D+ +  SPF   +    G  
Sbjct: 584  FAIEGPSQAKIEYDDQNDGSCDVKYWPKEPGEYAVHIMCDDEDIKDSPFMAYIHPASGDY 643

Query: 1221 KESITRRQ---RAPSVANVGSHCDLSLKIPEISIQDMTAQVTSPSGKSHEAEIVEGENHT 1391
               + +        S   V +  + ++   +     +        G+  + ++    + T
Sbjct: 644  NPDLVQAYGPGLEKSGCIVNNLAEFTVDPKDAGKAPLKIFAQDGDGQPIDIQMKSRMDGT 703

Query: 1392 YCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAH--KVRAGGPGLERA--EA 1559
            Y   + P +   HT++V + G ++P SP++ ++G     G+H  KV+  GPG+ER+  +A
Sbjct: 704  YACSYTPVKAIKHTIAVVWGGVNIPHSPYRVSIGQ----GSHPQKVKVFGPGVERSGLKA 759

Query: 1560 GVPAEFSIWTREAGAGGLAIAVE------GPSKAEISFE--DRKDGSCGVAYVVQEPGDY 1715
              P  F++   EAG G +++ ++         + ++ F+     + +  V YV    G Y
Sbjct: 760  HEPTHFTVDCTEAGEGDVSVGIKCDARVLSDEEEDVDFDIIHNANDTFTVKYVPPAAGRY 819

Query: 1716 EVSVKFNEEHIPDSPFVVPVASPSGDARRLTVS--SLQESGLKVNQPASFAVSLNGA-KG 1886
             + V F  + IP SPF V V  PS DA ++      L ++G++  +P  F V   GA K 
Sbjct: 820  TIKVLFASQEIPTSPFRVKV-DPSHDASKVKAEGPGLSKAGVENGKPTHFTVYTKGAGKA 878

Query: 1887 AIDAKVHS--PSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRV 2060
             ++ +  S  P  A+++  + +     + V++ P + G   + V + G  IP SPF + V
Sbjct: 879  PLNVQFSSPGPGDAVKDLDIIDNYDYSHTVKYTPTQQGNMQVLVTYGGDPIPKSPFTVGV 938

Query: 2061 GEPGHGGDPGLVSAYGAGLEGGV-TGSPAEFIVNTSNAGA-GALSVTIDGPSKVKMDCQE 2234
              P       L      GLE  V  G   EF V+T  AG  G L VTI  PS+  + C  
Sbjct: 939  AAP-----LDLSRIKINGLENRVEVGKDQEFAVDTRGAGGQGKLDVTILSPSRKVVPCLV 993

Query: 2235 CP----EGYRVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSVF 2402
             P    EG    + P   G Y I + Y G + + GSP+    +                 
Sbjct: 994  APMAGREGSTAKFIPREEGLYAIDLTYDG-HPVPGSPYVVEAS----------------- 1035

Query: 2403 VDSLTKTXXXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKAGNNMLLVGV 2582
                                   +KV A G GL    VG+   FT+D   AG   L + V
Sbjct: 1036 ------------------LPPDPTKVKAHGPGLRGGLVGKPAEFTIDTKGAGTGGLGLTV 1077

Query: 2583 HGPRTPCE-EILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYR 2729
             G   PCE +I     G    SVSYL    GEY + + + + HIPGSP++
Sbjct: 1078 EG---PCEAKIECSDNGDGTCSVSYLPTKPGEYFVNILFEEVHIPGSPFK 1124



 Score =  277 bits (709), Expect = 4e-74
 Identities = 238/885 (26%), Positives = 379/885 (42%), Gaps = 40/885 (4%)
 Frame = +3

Query: 204  GEITGEVRMPSGKVAQPAITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFYVD 383
            GE+   ++ P G          +DG     Y PS  G + + I +   HI  SP +  V 
Sbjct: 485  GELGVTIKGPKGLEELVKQKGFQDGVYAFEYYPSTQGKYSVSITWGGHHIQKSPFEVQVG 544

Query: 384  -YVNCGHVTAYGPGLSHGVVNKPAVFTVNTKDAGEGGLSLAIEGPSKAEISCTDNQDGTC 560
                   V A+GPGL  G+V + A F V +  +  G L  AIEGPS+A+I   D  DG+C
Sbjct: 545  PEAGMQKVRAWGPGLHGGIVGRSADFVVESIGSEVGSLGFAIEGPSQAKIEYDDQNDGSC 604

Query: 561  SVSYLPVLPGDYSILVKYNEQHIPGSPFTARV---TGD----------DSMRMSHLKVGS 701
             V Y P  PG+Y++ +  +++ I  SPF A +   +GD            +  S   V +
Sbjct: 605  DVKYWPKEPGEYAVHIMCDDEDIKDSPFMAYIHPASGDYNPDLVQAYGPGLEKSGCIVNN 664

Query: 702  AADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNG 881
             A+  ++  +   + L        G+     +K   +G    S+ P +  +H + V   G
Sbjct: 665  LAEFTVDPKDAGKAPLKIFAQDGDGQPIDIQMKSRMDGTYACSYTPVKAIKHTIAVVWGG 724

Query: 882  QHVASSPIPVVISQSEIGDASRVRVSGRGLHEG--HTFEPAEFIIDTRDAGYGGLSLSIE 1055
             ++  SP  V I Q       +V+V G G+        EP  F +D  +AG G +S+ I+
Sbjct: 725  VNIPHSPYRVSIGQG--SHPQKVKVFGPGVERSGLKAHEPTHFTVDCTEAGEGDVSVGIK 782

Query: 1056 GPSKVDINTEDLED--------GTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVT-- 1205
              ++V  + E+  D         T  V Y P   G Y I + FA Q +P SPF VKV   
Sbjct: 783  CDARVLSDEEEDVDFDIIHNANDTFTVKYVPPAAGRYTIKVLFASQEIPTSPFRVKVDPS 842

Query: 1206 -GEGRVKESITRRQRAPSVANVGSHCDLSLKIPEISIQDMTAQVTSPSGKSHEAEIVEGE 1382
                +VK       +A       +H  +  K    +  ++      P     + +I++  
Sbjct: 843  HDASKVKAEGPGLSKAGVENGKPTHFTVYTKGAGKAPLNVQFSSPGPGDAVKDLDIIDNY 902

Query: 1383 NHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLE-RAEA 1559
            ++++ +++ P + G   V V Y G  +P SP  FTVG        +++    GLE R E 
Sbjct: 903  DYSHTVKYTPTQQGNMQVLVTYGGDPIPKSP--FTVGVAAPLDLSRIKIN--GLENRVEV 958

Query: 1560 GVPAEFSIWTREAGA-GGLAIAVEGPSK----AEISFEDRKDGSCGVAYVVQEPGDYEVS 1724
            G   EF++ TR AG  G L + +  PS+      ++    ++GS    ++ +E G Y + 
Sbjct: 959  GKDQEFAVDTRGAGGQGKLDVTILSPSRKVVPCLVAPMAGREGST-AKFIPREEGLYAID 1017

Query: 1725 VKFNEEHIPDSPFVVPVASPSGDARRLTVSSLQESGLKVNQPASFAVSLNGA-KGAIDAK 1901
            + ++   +P SP+VV  + P  D  ++        G  V +PA F +   GA  G +   
Sbjct: 1018 LTYDGHPVPGSPYVVEASLPP-DPTKVKAHGPGLRGGLVGKPAEFTIDTKGAGTGGLGLT 1076

Query: 1902 VHSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGG 2081
            V  P  A  EC  ++      +V ++P + G Y +++ F   HIPGSPFK  +  P    
Sbjct: 1077 VEGPCEAKIEC--SDNGDGTCSVSYLPTKPGEYFVNILFEEVHIPGSPFKADIEMP---F 1131

Query: 2082 DPGLVSAYGAGLEGGVTGSPAEFIVNTSNAGAGALSV--TIDGPSKVKMDCQECPEG-YR 2252
            DP  V A G GLE G  G P    V+ S AG G L +    D  +K ++  +   +G Y 
Sbjct: 1132 DPSKVVASGPGLEHGKVGEPGLLSVDCSEAGPGTLGLEAVSDSGAKAEVCIENNKDGTYA 1191

Query: 2253 VTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSVFVDSLTKTXXX 2432
            VTY P+  G Y +++KYGG   +   P + +V            +TS V           
Sbjct: 1192 VTYVPLTAGMYTLTMKYGGEL-VPHFPTRVKV--------EPAVDTSRV----------- 1231

Query: 2433 XXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVD---CSKAGNNMLLVGVHGPRTPC 2603
                          KV   G+     +      FTVD    ++ G + +   +  P    
Sbjct: 1232 --------------KVFGPGIEGKDVFREATTDFTVDSRPLTQVGGDHIKAHIANPSGAS 1277

Query: 2604 EEILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLV 2738
             E  V       Y V Y   +KG + + V + D  +P SP++V V
Sbjct: 1278 TECFVTDNADGTYQVEYTPFEKGLHVVEVTYDDVPVPNSPFKVAV 1322



 Score =  252 bits (643), Expect = 2e-66
 Identities = 201/687 (29%), Positives = 308/687 (44%), Gaps = 29/687 (4%)
 Frame = +3

Query: 759  VVPPSGREEPCLLK--RLRNGHVGISFVPKETGEHLVHVKKNGQHVASSPIPVVISQSEI 932
            V  P G +E  L+     +N    + ++PK TG H V V   GQH++ SP  V + +++ 
Sbjct: 293  VEDPEGNKEEALVTPDSDKNKTYSVEYLPKVTGLHKVTVLFAGQHISKSPFEVNVDKAQ- 351

Query: 933  GDASRVRVSGRGLHEGHTF--EPAEFIIDTRDAGYGGLSLSIEGP---SKVDINTEDLED 1097
            GDAS+V   G GL        +P  F I T  AG G + + +E P   + V++  ED  +
Sbjct: 352  GDASKVTAKGPGLEVASNIANKPTYFDIYTAGAGVGDIGVEVEDPQGKNTVELLVEDRGN 411

Query: 1098 GTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTGEGRVKESITRRQRA--PSVANVG 1271
               R  Y P +PG +++ + FA   +P SPF V+V GE     +     R   P    + 
Sbjct: 412  QVYRCVYKPMQPGPHVVKVSFAGDTIPKSPFVVQV-GEACNPNACRASGRGLQPKGIRIR 470

Query: 1272 SHCDLSLKIPEISIQDMTAQVTSPSGKSHEAEIVEGENHTYCIRFVPAEMGMHTVSVKYK 1451
               D  +        ++   +  P G     +    ++  Y   + P+  G ++VS+ + 
Sbjct: 471  ETADFKVDTKAAGSGELGVTIKGPKGLEELVKQKGFQDGVYAFEYYPSTQGKYSVSITWG 530

Query: 1452 GQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLERAEAGVPAEFSIWTREAGAGGLAIAVEG 1631
            G H+  SPF+  VGP  E G  KVRA GPGL     G  A+F + +  +  G L  A+EG
Sbjct: 531  GHHIQKSPFEVQVGP--EAGMQKVRAWGPGLHGGIVGRSADFVVESIGSEVGSLGFAIEG 588

Query: 1632 PSKAEISFEDRKDGSCGVAYVVQEPGDYEVSVKFNEEHIPDSPFVVPVASPSGDARRLTV 1811
            PS+A+I ++D+ DGSC V Y  +EPG+Y V +  ++E I DSPF+  +   SGD     V
Sbjct: 589  PSQAKIEYDDQNDGSCDVKYWPKEPGEYAVHIMCDDEDIKDSPFMAYIHPASGDYNPDLV 648

Query: 1812 SS----LQESGLKVNQPASFAVSLNGA-KGAIDAKVHSPSGALEECYVTEIDQDKYAVRF 1976
             +    L++SG  VN  A F V    A K  +        G   +  +       YA  +
Sbjct: 649  QAYGPGLEKSGCIVNNLAEFTVDPKDAGKAPLKIFAQDGDGQPIDIQMKSRMDGTYACSY 708

Query: 1977 IPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPGLVSAYGAGLE--GGVTGSPAEF 2150
             P +   + I V + G +IP SP+++ +G+  H   P  V  +G G+E  G     P  F
Sbjct: 709  TPVKAIKHTIAVVWGGVNIPHSPYRVSIGQGSH---PQKVKVFGPGVERSGLKAHEPTHF 765

Query: 2151 IVNTSNAGAGALSVTIDGPSKVKMDCQE---------CPEGYRVTYTPMAPGSYLISIKY 2303
             V+ + AG G +SV I   ++V  D +E           + + V Y P A G Y I + +
Sbjct: 766  TVDCTEAGEGDVSVGIKCDARVLSDEEEDVDFDIIHNANDTFTVKYVPPAAGRYTIKVLF 825

Query: 2304 GGPYHIGGSPFKARVTGHRLVSNHSLHETSSVFVDSLTKTXXXXXXXXXXXXXXXXSKVL 2483
                 I  SPF+ +V       +H                                SKV 
Sbjct: 826  AS-QEIPTSPFRVKVD-----PSHD------------------------------ASKVK 849

Query: 2484 AKGLGLSKAYV--GQKGSFTVDCSKAGNNMLLV--GVHGPRTPCEEILVKHVGSRLYSVS 2651
            A+G GLSKA V  G+   FTV    AG   L V     GP    +++ +       ++V 
Sbjct: 850  AEGPGLSKAGVENGKPTHFTVYTKGAGKAPLNVQFSSPGPGDAVKDLDIIDNYDYSHTVK 909

Query: 2652 YLLKDKGEYTLVVKWGDEHIPGSPYRV 2732
            Y    +G   ++V +G + IP SP+ V
Sbjct: 910  YTPTQQGNMQVLVTYGGDPIPKSPFTV 936



 Score =  222 bits (566), Expect = 1e-57
 Identities = 229/840 (27%), Positives = 359/840 (42%), Gaps = 47/840 (5%)
 Frame = +3

Query: 354  PGSPLQFYVDYVNCGHVTAYGPGL--SHGVVNKPAVFTVNTKDAGEGGLSLAIEGP--SK 521
            PG+PL+     +N     AYG G+  +  +V +PA FTV+T  AG+G + + +E P  +K
Sbjct: 244  PGAPLK---PKLNPKKARAYGRGIEPTGNMVKQPAKFTVDTISAGQGDVMVFVEDPEGNK 300

Query: 522  AEISCTDNQD--GTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARVTGDDSMRMSHLKV 695
             E   T + D   T SV YLP + G + + V +  QHI  SPF   V             
Sbjct: 301  EEALVTPDSDKNKTYSVEYLPKVTGLHKVTVLFAGQHISKSPFEVNVDKAQGDASKVTAK 360

Query: 696  GSAADIPINISE--TDLSLLTA---------TVVPPSGREEPCLLKRLRNGHV-GISFVP 839
            G   ++  NI+   T   + TA          V  P G+    LL   R   V    + P
Sbjct: 361  GPGLEVASNIANKPTYFDIYTAGAGVGDIGVEVEDPQGKNTVELLVEDRGNQVYRCVYKP 420

Query: 840  KETGEHLVHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEG--HTFEPAEFIID 1013
             + G H+V V   G  +  SP   V+   E  + +  R SGRGL        E A+F +D
Sbjct: 421  MQPGPHVVKVSFAGDTIPKSPF--VVQVGEACNPNACRASGRGLQPKGIRIRETADFKVD 478

Query: 1014 TRDAGYGGLSLSIEGPSKVD--INTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSP 1187
            T+ AG G L ++I+GP  ++  +  +  +DG     Y P+  G Y ++I +   H+  SP
Sbjct: 479  TKAAGSGELGVTIKGPKGLEELVKQKGFQDGVYAFEYYPSTQGKYSVSITWGGHHIQKSP 538

Query: 1188 FSVKVTGEGRVKESITRRQRAPSVAN--VGSHCDLSLKIPEISIQDMTAQVTSPSGKSHE 1361
            F V+V  E  +++    R   P +    VG   D  ++     +  +   +  PS    E
Sbjct: 539  FEVQVGPEAGMQKV---RAWGPGLHGGIVGRSADFVVESIGSEVGSLGFAIEGPSQAKIE 595

Query: 1362 AEIVEGENHTYC-IRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPL-GEGGAHKVRAGG 1535
                + +N   C +++ P E G + V +    + +  SPF   + P  G+     V+A G
Sbjct: 596  ---YDDQNDGSCDVKYWPKEPGEYAVHIMCDDEDIKDSPFMAYIHPASGDYNPDLVQAYG 652

Query: 1536 PGLERAEAGVP--AEFSIWTREAGAGGLAI-AVEGPSK-AEISFEDRKDGSCGVAYVVQE 1703
            PGLE++   V   AEF++  ++AG   L I A +G  +  +I  + R DG+   +Y   +
Sbjct: 653  PGLEKSGCIVNNLAEFTVDPKDAGKAPLKIFAQDGDGQPIDIQMKSRMDGTYACSYTPVK 712

Query: 1704 PGDYEVSVKFNEEHIPDSPFVVPVASPSGDAR-RLTVSSLQESGLKVNQPASFAVSLNGA 1880
               + ++V +   +IP SP+ V +   S   + ++    ++ SGLK ++P  F V    A
Sbjct: 713  AIKHTIAVVWGGVNIPHSPYRVSIGQGSHPQKVKVFGPGVERSGLKAHEPTHFTVDCTEA 772

Query: 1881 -KGAI------DAKVHSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPG 2039
             +G +      DA+V S      +  +     D + V+++P   G Y I V F    IP 
Sbjct: 773  GEGDVSVGIKCDARVLSDEEEDVDFDIIHNANDTFTVKYVPPAAGRYTIKVLFASQEIPT 832

Query: 2040 SPFKIRVGEPGHGGDPGLVSAYGAGLE--GGVTGSPAEFIVNTSNAGAGALSVTID--GP 2207
            SPF+++V +P H  D   V A G GL   G   G P  F V T  AG   L+V     GP
Sbjct: 833  SPFRVKV-DPSH--DASKVKAEGPGLSKAGVENGKPTHFTVYTKGAGKAPLNVQFSSPGP 889

Query: 2208 SKVKMD---CQECPEGYRVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHS 2378
                 D          + V YTP   G+  + + YGG   I  SPF   V          
Sbjct: 890  GDAVKDLDIIDNYDYSHTVKYTPTQQGNMQVLVTYGGD-PIPKSPFTVGVAA-------- 940

Query: 2379 LHETSSVFVDSLTKTXXXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKA- 2555
                                           S++   GL  ++  VG+   F VD   A 
Sbjct: 941  ---------------------------PLDLSRIKINGLE-NRVEVGKDQEFAVDTRGAG 972

Query: 2556 GNNMLLVGVHGPRTPCEEILVKHVGSRLYSVS-YLLKDKGEYTLVVKWGDEHIPGSPYRV 2732
            G   L V +  P       LV  +  R  S + ++ +++G Y + + +    +PGSPY V
Sbjct: 973  GQGKLDVTILSPSRKVVPCLVAPMAGREGSTAKFIPREEGLYAIDLTYDGHPVPGSPYVV 1032


>ref|NP_001193919.1| filamin-C [Bos taurus].
          Length = 2693

 Score =  798 bits (2060), Expect = 0.0
 Identities = 439/856 (51%), Positives = 558/856 (65%), Gaps = 24/856 (2%)
 Frame = +3

Query: 246  AQPAITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFYVDYVNCGHVTAYGPGL 425
            A+    DNKDGT TV Y P+  G + + +R+D+ HIPGSP    +   +    +    G 
Sbjct: 1870 AEITCKDNKDGTCTVSYLPTAPGDYSIIVRFDDKHIPGSPFTAKITGDDSMRTSQLNVGT 1929

Query: 426  SHGVVNKPAVFTVNTKDAGEGGLSLAIEGPSKAEISCTDNQ--DGTCSVSYLPVLPGDYS 599
            S  V  K     +   D  +  L+ +I  PS  E  C   +  +    +S+ P   G++ 
Sbjct: 1930 STDVSLK-----ITESDLSQ--LTASIRAPSGNEEPCLLKRLPNRHIGISFTPKEVGEHV 1982

Query: 600  ILVKYNEQHIPGSPFTARVTGDDSMRMSHLKVGS----------AADIPINISETDLSLL 749
            + V+ + +H+  SPF   V   +    S ++V             A+  ++        L
Sbjct: 1983 VSVRKSGKHVTNSPFKILVGPSEIGDASKVRVWGKGLSEGHTFQVAEFIVDTRNAGYGGL 2042

Query: 750  TATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNGQHVASSPIPVVISQSE 929
              ++  PS  +  C  + + +G   +++ P E G +++++K   +HV  SP  V ++   
Sbjct: 2043 GLSIEGPSKVDINC--EDMEDGTCKVTYCPTEPGTYIINIKFADKHVPGSPFTVKVTGE- 2099

Query: 930  IGDASRVRVSGRGLHEGHTFEPAEFIIDTR---DAGYGGLSLSIEGPSKVDINTEDLEDG 1100
                 R++ S     +  +        D        +  +  + E  ++    +      
Sbjct: 2100 ----GRMKESITRRRQAPSIATIGSTCDLNLKIPGNWFQMVSAQERLTRTFTRSSHTYTR 2155

Query: 1101 TCRVTYCPTEPGNYIINIKFADQ-HVPGSPFSVKVTGEGRVKE------SITRRQRAPSV 1259
            T R     T  G     ++  +   V G PF   V G+   +E      SITR+Q     
Sbjct: 2156 TERTEISKTRGGETKREVRVEESTQVGGDPFPA-VFGDFLGRERLGSFGSITRQQEG--- 2211

Query: 1260 ANVGSHCDLSLKIPEISIQDMTAQVTSPSGKSHEAEIVEGENHTYCIRFVPAEMGMHTVS 1439
                          E S QDMTAQVTSPSGK+  AEIVEGE+  Y +RFVP EMG HTV+
Sbjct: 2212 --------------EASSQDMTAQVTSPSGKTEAAEIVEGEDSAYSVRFVPQEMGPHTVT 2257

Query: 1440 VKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLERAEAGVPAEFSIWTREAGAGGLAI 1619
            VKY+GQHVPGSPFQFTVGPLGEGGAHKVRAGG GLER  AGVPAEFSIWTREAGAGGL+I
Sbjct: 2258 VKYRGQHVPGSPFQFTVGPLGEGGAHKVRAGGTGLERGVAGVPAEFSIWTREAGAGGLSI 2317

Query: 1620 AVEGPSKAEISFEDRKDGSCGVAYVVQEPGDYEVSVKFNEEHIPDSPFVVPVASPSGDAR 1799
            AVEGPSKAEI+FEDRKDGSCGV+YVVQEPGDYEVS+KFN+EHIPDSPFVVPVAS S DAR
Sbjct: 2318 AVEGPSKAEIAFEDRKDGSCGVSYVVQEPGDYEVSIKFNDEHIPDSPFVVPVASLSDDAR 2377

Query: 1800 RLTVSSLQESGLKVNQPASFAVSLNGAKGAIDAKVHSPSGALEECYVTEIDQDKYAVRFI 1979
            RLTV+SLQE+GLKVNQPASFAV LNGA+G IDA+VH+PSGA+EECYV+E+D DK+ +RFI
Sbjct: 2378 RLTVTSLQETGLKVNQPASFAVQLNGARGVIDARVHTPSGAVEECYVSELDSDKHTIRFI 2437

Query: 1980 PRENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPGLVSAYGAGLEGGVTGSPAEFIVN 2159
            P ENGV+ IDVKFNG HIPGSPFKIRVGE    GDPGLVSAYG GLEGG TG  +EFIVN
Sbjct: 2438 PHENGVHSIDVKFNGAHIPGSPFKIRVGEQSQAGDPGLVSAYGPGLEGGTTGVSSEFIVN 2497

Query: 2160 TSNAGAGALSVTIDGPSKVKMDCQECPEGYRVTYTPMAPGSYLISIKYGGPYHIGGSPFK 2339
            T NAG+GALSVTIDGPSKV++DC+ECPEG+ VTYTPMAPG+YLI+IKYGGP HI GSPFK
Sbjct: 2498 TLNAGSGALSVTIDGPSKVQLDCRECPEGHVVTYTPMAPGNYLIAIKYGGPQHIVGSPFK 2557

Query: 2340 ARVTGHRLVSNHSLHETSSVFVDSLTK--TXXXXXXXXXXXXXXXXSKVLAKGLGLSKAY 2513
            A+VTG RL   HSLHETS+V V+++TK  +                SKV+ +G GLS+A+
Sbjct: 2558 AKVTGPRLSGGHSLHETSTVLVETVTKSSSSRGSSYSSIPKFSSDASKVVTRGPGLSQAF 2617

Query: 2514 VGQKGSFTVDCSKAGNNMLLVGVHGPRTPCEEILVKHVGSRLYSVSYLLKDKGEYTLVVK 2693
            VGQK SFTVDCSKAG NM++VGVHGP+TPCEE+ VKH+G+R+Y+V+Y +K+KG+Y L+VK
Sbjct: 2618 VGQKNSFTVDCSKAGTNMMMVGVHGPKTPCEEVYVKHMGNRVYNVTYTVKEKGDYILIVK 2677

Query: 2694 WGDEHIPGSPYRVLVP 2741
            WGDE +PGSP++V VP
Sbjct: 2678 WGDESVPGSPFKVNVP 2693



 Score =  698 bits (1801), Expect = 0.0
 Identities = 406/887 (45%), Positives = 526/887 (59%), Gaps = 12/887 (1%)
 Frame = +3

Query: 114  APERPLVGVNGLDVTSLRPFDLVIPFTIKKGEITGEVRMPSGKVAQPAITDNKDGTVTVR 293
            A E P+V    ++ + LRPF+LVIPFT++KGE+TGEVRMPSGK A+P ITDNKDGT+TVR
Sbjct: 1735 ATEEPVVPAEPME-SMLRPFNLVIPFTVQKGELTGEVRMPSGKTARPNITDNKDGTITVR 1793

Query: 294  YAPSEAGLHEMDIRYDNMHIPGSPLQFYVDYVNCGHVTAYGPGLSHGVVNKPAVFTVNTK 473
            YAP+E GLH+M I+YD  HIPGSPLQFYVD +N  HV+AYGPGLSHG+VNKPA FT+ TK
Sbjct: 1794 YAPTEKGLHQMGIKYDGNHIPGSPLQFYVDAINSRHVSAYGPGLSHGMVNKPATFTIVTK 1853

Query: 474  DAGEGGLSLAIEGPSKAEISCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTAR 653
            DAGEGGLSLA+EGPSKAEI+C DN+DGTC+VSYLP  PGDYSI+V+++++HIPGSPFTA+
Sbjct: 1854 DAGEGGLSLAVEGPSKAEITCKDNKDGTCTVSYLPTAPGDYSIIVRFDDKHIPGSPFTAK 1913

Query: 654  VTGDDSMRMSHLKVGSAADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISF 833
            +TGDDSMR S L VG++ D+ + I+E+DLS LTA++  PSG EEPCLLKRL N H+GISF
Sbjct: 1914 ITGDDSMRTSQLNVGTSTDVSLKITESDLSQLTASIRAPSGNEEPCLLKRLPNRHIGISF 1973

Query: 834  VPKETGEHLVHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEGHTFEPAEFIID 1013
             PKE GEH+V V+K+G+HV +SP  +++  SEIGDAS+VRV G+GL EGHTF+ AEFI+D
Sbjct: 1974 TPKEVGEHVVSVRKSGKHVTNSPFKILVGPSEIGDASKVRVWGKGLSEGHTFQVAEFIVD 2033

Query: 1014 TRDAGYGGLSLSIEGPSKVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFS 1193
            TR+AGYGGL LSIEGPSKVDIN ED+EDGTC+VTYCPTEPG YIINIKFAD+HVPGSPF+
Sbjct: 2034 TRNAGYGGLGLSIEGPSKVDINCEDMEDGTCKVTYCPTEPGTYIINIKFADKHVPGSPFT 2093

Query: 1194 VKVTGEGRVKESITRRQRAPSVANVGSHCDLSLKIPEISIQDMTAQVTSPSGKSHEAEIV 1373
            VKVTGEGR+KESITRR++APS+A +GS CDL+LKIP    Q ++AQ       +  +   
Sbjct: 2094 VKVTGEGRMKESITRRRQAPSIATIGSTCDLNLKIPGNWFQMVSAQERLTRTFTRSSHTY 2153

Query: 1374 EGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPG-LER 1550
                 T   +    E     V V+   Q V G PF    G        + R G  G + R
Sbjct: 2154 TRTERTEISKTRGGET-KREVRVEESTQ-VGGDPFPAVFGDF----LGRERLGSFGSITR 2207

Query: 1551 AEAGVPAEFSIWTREAGAGGLAIAVEGPS-KAEIS-FEDRKDGSCGVAYVVQEPGDYEVS 1724
             + G          EA +  +   V  PS K E +   + +D +  V +V QE G + V+
Sbjct: 2208 QQEG----------EASSQDMTAQVTSPSGKTEAAEIVEGEDSAYSVRFVPQEMGPHTVT 2257

Query: 1725 VKFNEEHIPDSPFVVPVAS-PSGDARRLTVSSLQESGLKVNQPASFAV-SLNGAKGAIDA 1898
            VK+  +H+P SPF   V     G A ++              PA F++ +     G +  
Sbjct: 2258 VKYRGQHVPGSPFQFTVGPLGEGGAHKVRAGGTGLERGVAGVPAEFSIWTREAGAGGLSI 2317

Query: 1899 KVHSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGHG 2078
             V  PS A  E    +       V ++ +E G Y + +KFN  HIP SPF + V      
Sbjct: 2318 AVEGPSKA--EIAFEDRKDGSCGVSYVVQEPGDYEVSIKFNDEHIPDSPFVVPVA--SLS 2373

Query: 2079 GDPGLVSAYGAGLEGGVTGSPAEFIVNTSNAGAGALSVTIDGPSKVKMDC---QECPEGY 2249
             D   ++       G     PA F V   N   G +   +  PS    +C   +   + +
Sbjct: 2374 DDARRLTVTSLQETGLKVNQPASFAVQL-NGARGVIDARVHTPSGAVEECYVSELDSDKH 2432

Query: 2250 RVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSVFVDSLTKTXX 2429
             + + P   G + I +K+ G  HI GSPFK RV       +  L                
Sbjct: 2433 TIRFIPHENGVHSIDVKFNGA-HIPGSPFKIRVGEQSQAGDPGL---------------- 2475

Query: 2430 XXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKAGNNMLLVGVHGP---RTP 2600
                            V A G GL     G    F V+   AG+  L V + GP   +  
Sbjct: 2476 ----------------VSAYGPGLEGGTTGVSSEFIVNTLNAGSGALSVTIDGPSKVQLD 2519

Query: 2601 CEEILVKHVGSRLYSVSYLLKDKGEYTLVVKW-GDEHIPGSPYRVLV 2738
            C E    HV      V+Y     G Y + +K+ G +HI GSP++  V
Sbjct: 2520 CRECPEGHV------VTYTPMAPGNYLIAIKYGGPQHIVGSPFKAKV 2560



 Score =  420 bits (1080), Expect = e-117
 Identities = 254/731 (34%), Positives = 385/731 (52%), Gaps = 28/731 (3%)
 Frame = +3

Query: 246  AQPAITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFYV-DYVNCGHVTAYGPG 422
            A+ +  DNKDG+ TV Y P   G ++++I +    IPGSP +  V D V+ G V   GPG
Sbjct: 1394 AKMSCKDNKDGSCTVEYIPFTPGDYDVNITFGGRPIPGSPFRVPVKDVVDPGKVKCSGPG 1453

Query: 423  LSHGV-VNKPAVFTVNTKDAGEGGLSLAIEGPSKAE--ISCTDNQDGTCSVSYLPVLPGD 593
            L  GV    P  FTV+   AG   L +A+ GP+     +   DN DGT +V Y P   G 
Sbjct: 1454 LGAGVRARVPQTFTVDCSQAGRAPLQVAVLGPTGVAEPVEVRDNGDGTHTVHYTPATDGP 1513

Query: 594  YSILVKYNEQHIPGSPFTARV----------TGDDSMRMSHLKVGSAADIPINISETDLS 743
            Y++ VKY +Q +P SPF  +V               +  S +      +  I+  +    
Sbjct: 1514 YTVAVKYADQEVPRSPFKIKVLPAHDASKVRASGPGLNASGIPASLPVEFTIDARDAGEG 1573

Query: 744  LLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNGQHVASSPIPVVISQ 923
            LLT  ++ P G+ +   ++   +G   +S++P  +G + + +K  G  +  SP    I  
Sbjct: 1574 LLTVQILDPEGKPKKANIRDNGDGTYTVSYLPDMSGRYTITIKYGGDEIPYSPFR--IHA 1631

Query: 924  SEIGDASR----VRVSGRGLHE--GHTFEPAE---FIIDTRDAGYGGLSLSIEGP--SKV 1070
               GDAS+    V + G GL    G   +  E     +D + AG G ++ ++  P  +++
Sbjct: 1632 LPTGDASKCLVTVSIGGHGLGACLGPRIQIGEETVITVDAKAAGKGKVTCTVSTPDGAEL 1691

Query: 1071 DINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTGEGRVKESITRRQRA 1250
            D++  +  DGT  + Y   EPG Y+I I+F  +H+P SPF V  T E  V          
Sbjct: 1692 DVDVVENHDGTFDIYYTAPEPGKYVITIRFGGEHIPNSPFHVLATEEPVVPAEPMESMLR 1751

Query: 1251 PSVANVGSHCDLSLKIP-EISIQDMTAQVTSPSGKSHEAEIVEGENHTYCIRFVPAEMGM 1427
            P           +L IP  +   ++T +V  PSGK+    I + ++ T  +R+ P E G+
Sbjct: 1752 P----------FNLVIPFTVQKGELTGEVRMPSGKTARPNITDNKDGTITVRYAPTEKGL 1801

Query: 1428 HTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLERAEAGVPAEFSIWTREAGAG 1607
            H + +KY G H+PGSP QF V  +    +  V A GPGL       PA F+I T++AG G
Sbjct: 1802 HQMGIKYDGNHIPGSPLQFYVDAIN---SRHVSAYGPGLSHGMVNKPATFTIVTKDAGEG 1858

Query: 1608 GLAIAVEGPSKAEISFEDRKDGSCGVAYVVQEPGDYEVSVKFNEEHIPDSPFVVPVASPS 1787
            GL++AVEGPSKAEI+ +D KDG+C V+Y+   PGDY + V+F+++HIP SPF   +   +
Sbjct: 1859 GLSLAVEGPSKAEITCKDNKDGTCTVSYLPTAPGDYSIIVRFDDKHIPGSPFTAKI---T 1915

Query: 1788 GDARRLTVSSLQESGLKVNQPASFAVSLNGAK-GAIDAKVHSPSGALEECYVTEIDQDKY 1964
            GD       S++ S L V      ++ +  +    + A + +PSG  E C +  +     
Sbjct: 1916 GD------DSMRTSQLNVGTSTDVSLKITESDLSQLTASIRAPSGNEEPCLLKRLPNRHI 1969

Query: 1965 AVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPGLVSAYGAGLEGGVTGSPA 2144
             + F P+E G +++ V+ +G H+  SPFKI VG P   GD   V  +G GL  G T   A
Sbjct: 1970 GISFTPKEVGEHVVSVRKSGKHVTNSPFKILVG-PSEIGDASKVRVWGKGLSEGHTFQVA 2028

Query: 2145 EFIVNTSNAGAGALSVTIDGPSKVKMDCQECPEGY-RVTYTPMAPGSYLISIKYGGPYHI 2321
            EFIV+T NAG G L ++I+GPSKV ++C++  +G  +VTY P  PG+Y+I+IK+    H+
Sbjct: 2029 EFIVDTRNAGYGGLGLSIEGPSKVDINCEDMEDGTCKVTYCPTEPGTYIINIKFADK-HV 2087

Query: 2322 GGSPFKARVTG 2354
             GSPF  +VTG
Sbjct: 2088 PGSPFTVKVTG 2098



 Score =  389 bits (999), Expect = e-108
 Identities = 281/896 (31%), Positives = 419/896 (46%), Gaps = 31/896 (3%)
 Frame = +3

Query: 144  GLDVTSLRPFDLVIPFTIK-----KGEITGEVRMPSGKVAQPAITDNKDGTVTVRYAPSE 308
            GL+ + + P  L + FTI      +G +T ++  P GK  +  I DN DGT TV Y P  
Sbjct: 1549 GLNASGI-PASLPVEFTIDARDAGEGLLTVQILDPEGKPKKANIRDNGDGTYTVSYLPDM 1607

Query: 309  AGLHEMDIRYDNMHIPGSPLQFYV----DYVNCGHVTAYGPGLSHGV---------VNKP 449
            +G + + I+Y    IP SP + +     D   C    + G    HG+         + + 
Sbjct: 1608 SGRYTITIKYGGDEIPYSPFRIHALPTGDASKCLVTVSIG---GHGLGACLGPRIQIGEE 1664

Query: 450  AVFTVNTKDAGEGGLSLAIEGPSKAE--ISCTDNQDGTCSVSYLPVLPGDYSILVKYNEQ 623
             V TV+ K AG+G ++  +  P  AE  +   +N DGT  + Y    PG Y I +++  +
Sbjct: 1665 TVITVDAKAAGKGKVTCTVSTPDGAELDVDVVENHDGTFDIYYTAPEPGKYVITIRFGGE 1724

Query: 624  HIPGSPFTARVTGD---DSMRMSHLKVGSAADIPINISETDLSLLTATVVPPSGREEPCL 794
            HIP SPF    T +    +  M  +       IP  + + +   LT  V  PSG+     
Sbjct: 1725 HIPNSPFHVLATEEPVVPAEPMESMLRPFNLVIPFTVQKGE---LTGEVRMPSGKTARPN 1781

Query: 795  LKRLRNGHVGISFVPKETGEHLVHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLH 974
            +   ++G + + + P E G H + +K +G H+  SP+   +   +  ++  V   G GL 
Sbjct: 1782 ITDNKDGTITVRYAPTEKGLHQMGIKYDGNHIPGSPLQFYV---DAINSRHVSAYGPGLS 1838

Query: 975  EGHTFEPAEFIIDTRDAGYGGLSLSIEGPSKVDINTEDLEDGTCRVTYCPTEPGNYIINI 1154
             G   +PA F I T+DAG GGLSL++EGPSK +I  +D +DGTC V+Y PT PG+Y I +
Sbjct: 1839 HGMVNKPATFTIVTKDAGEGGLSLAVEGPSKAEITCKDNKDGTCTVSYLPTAPGDYSIIV 1898

Query: 1155 KFADQHVPGSPFSVKVTGEGRVKESITRRQRAPSVANVGSHCDLSLKIPEISIQDMTAQV 1334
            +F D+H+PGSPF+ K+TG+  ++          S  NVG+  D+SLKI E  +  +TA +
Sbjct: 1899 RFDDKHIPGSPFTAKITGDDSMR---------TSQLNVGTSTDVSLKITESDLSQLTASI 1949

Query: 1335 TSPSGKSHEAEIVEGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGA 1514
             +PSG      +    N    I F P E+G H VSV+  G+HV  SPF+  VGP   G A
Sbjct: 1950 RAPSGNEEPCLLKRLPNRHIGISFTPKEVGEHVVSVRKSGKHVTNSPFKILVGPSEIGDA 2009

Query: 1515 HKVRAGGPGLERAEAGVPAEFSIWTREAGAGGLAIAVEGPSKAEISFEDRKDGSCGVAYV 1694
             KVR  G GL        AEF + TR AG GGL +++EGPSK +I+ ED +DG+C V Y 
Sbjct: 2010 SKVRVWGKGLSEGHTFQVAEFIVDTRNAGYGGLGLSIEGPSKVDINCEDMEDGTCKVTYC 2069

Query: 1695 VQEPGDYEVSVKFNEEHIPDSPFVVPVASPSGDARRLTVSSLQESGLKVNQPASFAVSLN 1874
              EPG Y +++KF ++H+P SPF V V   +G+ R      ++ES  +  Q  S A    
Sbjct: 2070 PTEPGTYIINIKFADKHVPGSPFTVKV---TGEGR------MKESITRRRQAPSIAT--- 2117

Query: 1875 GAKGAIDAKVHSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFK- 2051
                  D  +  P       +   +   +   R   R +  Y    +   +   G   K 
Sbjct: 2118 -IGSTCDLNLKIPGN-----WFQMVSAQERLTRTFTRSSHTYTRTERTEISKTRGGETKR 2171

Query: 2052 -IRVGEPGH-GGDPGLVSAYGAGLEGGVTGSPAEFI-VNTSNAGAGALSVTIDGPSKVKM 2222
             +RV E    GGDP   + +G  L     GS           A +  ++  +  PS  K 
Sbjct: 2172 EVRVEESTQVGGDP-FPAVFGDFLGRERLGSFGSITRQQEGEASSQDMTAQVTSPSG-KT 2229

Query: 2223 DCQECPEG----YRVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHET 2390
            +  E  EG    Y V + P   G + +++KY G  H+ GSPF+  V              
Sbjct: 2230 EAAEIVEGEDSAYSVRFVPQEMGPHTVTVKYRG-QHVPGSPFQFTV-------------- 2274

Query: 2391 SSVFVDSLTKTXXXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKAGNNML 2570
                                        KV A G GL +   G    F++   +AG   L
Sbjct: 2275 -------------------GPLGEGGAHKVRAGGTGLERGVAGVPAEFSIWTREAGAGGL 2315

Query: 2571 LVGVHGPRTPCEEILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLV 2738
             + V GP     EI  +        VSY++++ G+Y + +K+ DEHIP SP+ V V
Sbjct: 2316 SIAVEGPSK--AEIAFEDRKDGSCGVSYVVQEPGDYEVSIKFNDEHIPDSPFVVPV 2369



 Score =  328 bits (841), Expect = 2e-89
 Identities = 249/881 (28%), Positives = 403/881 (45%), Gaps = 35/881 (3%)
 Frame = +3

Query: 201  KGEITGEVRMPSGKVAQPAITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFYV 380
            + E+T E+   +G  A+  I +N DGT  + Y+P+  G + + I+Y    +P  P + +V
Sbjct: 1186 EAELTIEILSDAGVKAEVLIHNNADGTYHITYSPAFPGTYTITIKYGGHPVPKFPTRVHV 1245

Query: 381  D-YVNCGHVTAYGPGLS-HGVVNKPAV-FTVNTKD---AGEGGLSLAIEGPS--KAEISC 536
               V+   V   GPG+  HGV+ +    FTV+ +     G   ++  +  PS  K +   
Sbjct: 1246 QPAVDTSGVKVSGPGVEPHGVLREVTTEFTVDARSLTATGGNHVTARVLNPSGAKTDTYV 1305

Query: 537  TDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARVT-GDDSMRMSHL-------K 692
            TDN DGT  V Y     G + + V Y++  +P SPF   VT G D  R+           
Sbjct: 1306 TDNGDGTYRVQYTAYEEGAHLVEVLYDDVAVPKSPFRVGVTEGCDPTRVRAFGPGLEGGL 1365

Query: 693  VGSAADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVK 872
            V  A    +         L   +  PS  +  C  K  ++G   + ++P   G++ V++ 
Sbjct: 1366 VNKANRFTVETRGAGTGGLGLAIEGPSEAKMSC--KDNKDGSCTVEYIPFTPGDYDVNIT 1423

Query: 873  KNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEG-HTFEPAEFIIDTRDAGYGGLSLS 1049
              G+ +  SP  V +   ++ D  +V+ SG GL  G     P  F +D   AG   L ++
Sbjct: 1424 FGGRPIPGSPFRVPV--KDVVDPGKVKCSGPGLGAGVRARVPQTFTVDCSQAGRAPLQVA 1481

Query: 1050 IEGPSKV--DINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTGEGRVK 1223
            + GP+ V   +   D  DGT  V Y P   G Y + +K+ADQ VP SPF +KV       
Sbjct: 1482 VLGPTGVAEPVEVRDNGDGTHTVHYTPATDGPYTVAVKYADQEVPRSPFKIKVL---PAH 1538

Query: 1224 ESITRRQRAPSVANVGSHCDLSLKIPEISIQD-----MTAQVTSPSGKSHEAEIVEGENH 1388
            ++   R   P +   G    L ++   I  +D     +T Q+  P GK  +A I +  + 
Sbjct: 1539 DASKVRASGPGLNASGIPASLPVEF-TIDARDAGEGLLTVQILDPEGKPKKANIRDNGDG 1597

Query: 1389 TYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGG--AHKVRAGGPGL-----E 1547
            TY + ++P   G +T+++KY G  +P SPF+    P G+       V  GG GL      
Sbjct: 1598 TYTVSYLPDMSGRYTITIKYGGDEIPYSPFRIHALPTGDASKCLVTVSIGGHGLGACLGP 1657

Query: 1548 RAEAGVPAEFSIWTREAGAGGLAIAVEGPSKAEISFE--DRKDGSCGVAYVVQEPGDYEV 1721
            R + G     ++  + AG G +   V  P  AE+  +  +  DG+  + Y   EPG Y +
Sbjct: 1658 RIQIGEETVITVDAKAAGKGKVTCTVSTPDGAELDVDVVENHDGTFDIYYTAPEPGKYVI 1717

Query: 1722 SVKFNEEHIPDSPF-VVPVASPSGDARRLTVSSLQESGLKVNQPASFAVSLNGAKGAIDA 1898
            +++F  EHIP+SPF V+    P   A  +      ES L+   P +  +     KG +  
Sbjct: 1718 TIRFGGEHIPNSPFHVLATEEPVVPAEPM------ESMLR---PFNLVIPFTVQKGELTG 1768

Query: 1899 KVHSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGHG 2078
            +V  PSG      +T+       VR+ P E G++ + +K++G HIPGSP +  V      
Sbjct: 1769 EVRMPSGKTARPNITDNKDGTITVRYAPTEKGLHQMGIKYDGNHIPGSPLQFYV----DA 1824

Query: 2079 GDPGLVSAYGAGLEGGVTGSPAEFIVNTSNAGAGALSVTIDGPSKVKMDCQECPEG-YRV 2255
             +   VSAYG GL  G+   PA F + T +AG G LS+ ++GPSK ++ C++  +G   V
Sbjct: 1825 INSRHVSAYGPGLSHGMVNKPATFTIVTKDAGEGGLSLAVEGPSKAEITCKDNKDGTCTV 1884

Query: 2256 TYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSVFVDSLTKTXXXX 2435
            +Y P APG Y I +++    HI GSPF A++TG                 D   +T    
Sbjct: 1885 SYLPTAPGDYSIIVRFDDK-HIPGSPFTAKITG-----------------DDSMRT---- 1922

Query: 2436 XXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKAGNNMLLVGVHGPRTPCEEIL 2615
                                  S+  VG     ++  +++  + L   +  P    E  L
Sbjct: 1923 ----------------------SQLNVGTSTDVSLKITESDLSQLTASIRAPSGNEEPCL 1960

Query: 2616 VKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLV 2738
            +K + +R   +S+  K+ GE+ + V+   +H+  SP+++LV
Sbjct: 1961 LKRLPNRHIGISFTPKEVGEHVVSVRKSGKHVTNSPFKILV 2001



 Score =  308 bits (789), Expect = 2e-83
 Identities = 267/894 (29%), Positives = 407/894 (45%), Gaps = 48/894 (5%)
 Frame = +3

Query: 201  KGEITGEVRMPSGKVAQPAITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFYV 380
            KG++    +   G      +  N DGT    Y P++   H + + +  +++P SP +  V
Sbjct: 700  KGDLKLYAQDADGCPIDIKVIPNGDGTFRCSYVPTKPIKHTIIVSWGGVNVPKSPFRVNV 759

Query: 381  -DYVNCGHVTAYGPGLSHG--VVNKPAVFTVNTKDAGEGGLSLAIE------GPSKAEI- 530
             +  +   V  YGPG+       N+P  FTV+  +AG+G +S+ I+      GP++A+I 
Sbjct: 760  GEGSHPERVKVYGPGVEKTGLKANEPTYFTVDCSEAGQGDVSIGIKCAPGVVGPAEADID 819

Query: 531  -SCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARVTGDDSMRMSHLKVGSAA 707
                 N + T +V Y P   G Y+I+V +  Q IP SPF  +V  D S   S +K   A 
Sbjct: 820  FDIIKNDNDTFTVKYTPPGAGRYTIMVLFANQEIPASPFHIKV--DPSHDASKVK---AE 874

Query: 708  DIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVG-----------------ISFV 836
               +N +  ++   T   V   G  +  L         G                 + + 
Sbjct: 875  GPGLNRTGVEVGKPTHFTVLTKGAGKAKLDVHFAGAAKGEAVRDFEIIDNHDYSYTVKYT 934

Query: 837  PKETGEHLVHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEGHTFEPAEFIIDT 1016
              + G   V V   G  V  SP   V++ +   D S+V+V G         E A F ++T
Sbjct: 935  AVQQGNMAVTVTYGGDPVPKSPF--VVNVAPPLDLSKVKVQGLNSKVAVGQEQA-FSVNT 991

Query: 1017 RDA-GYGGLSLSIEGPSKVDINTEDLEDG----TCRVTYCPTEPGNYIINIKFADQHVPG 1181
            R A G G L + +  PS+  I  + LE G    T  V Y P E G Y ++I +    VPG
Sbjct: 992  RGAGGQGQLDVRMTSPSRRPIPCK-LEPGGGAETQAVRYMPPEEGPYKVDITYDGHPVPG 1050

Query: 1182 SPFSVKVTGEGRVKESITR-RQRAPSVAN--VGSHCDLSLKIPEISIQDMTAQVTSPSGK 1352
            SPF+V    EG +    ++     P +    VG+    S+         +   V  P   
Sbjct: 1051 SPFAV----EGVLPPDPSKVCAYGPGLKGGLVGTPAPFSIDTKGAGTGGLGLTVEGPCEA 1106

Query: 1353 SHEAEIVEGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAG 1532
              E +  +  + +  + ++P E G +T+++ +   H+PGSPF+ T+ P+ +    KVRA 
Sbjct: 1107 KIECQ--DNGDGSCAVSYLPTEPGEYTINILFAEAHIPGSPFKATIRPVFD--PSKVRAS 1162

Query: 1533 GPGLERAEAGVPAEFSIWTREAGAGGLAIAV--EGPSKAEISFEDRKDGSCGVAYVVQEP 1706
            GPGLER +AG  A F++   EAG   L I +  +   KAE+   +  DG+  + Y    P
Sbjct: 1163 GPGLERGKAGEAATFTVDCSEAGEAELTIEILSDAGVKAEVLIHNNADGTYHITYSPAFP 1222

Query: 1707 GDYEVSVKFNEEHIPDSPFVVPVASPSGDARRLTVS--SLQESGLKVNQPASFAV---SL 1871
            G Y +++K+    +P  P  V V  P+ D   + VS   ++  G+       F V   SL
Sbjct: 1223 GTYTITIKYGGHPVPKFPTRVHV-QPAVDTSGVKVSGPGVEPHGVLREVTTEFTVDARSL 1281

Query: 1872 NGAKG-AIDAKVHSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPF 2048
                G  + A+V +PSGA  + YVT+     Y V++   E G +L++V ++   +P SPF
Sbjct: 1282 TATGGNHVTARVLNPSGAKTDTYVTDNGDGTYRVQYTAYEEGAHLVEVLYDDVAVPKSPF 1341

Query: 2049 KIRVGEPGHGGDPGLVSAYGAGLEGGVTGSPAEFIVNTSNAGAGALSVTIDGPSKVKMDC 2228
            ++ V E   G DP  V A+G GLEGG+      F V T  AG G L + I+GPS+ KM C
Sbjct: 1342 RVGVTE---GCDPTRVRAFGPGLEGGLVNKANRFTVETRGAGTGGLGLAIEGPSEAKMSC 1398

Query: 2229 QECPEG-YRVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSVFV 2405
            ++  +G   V Y P  PG Y ++I +GG   I GSPF+  V                  V
Sbjct: 1399 KDNKDGSCTVEYIPFTPGDYDVNITFGG-RPIPGSPFRVPVKD---------------VV 1442

Query: 2406 DSLTKTXXXXXXXXXXXXXXXXSKVLAKGLGLS---KAYVGQKGSFTVDCSKAGNNMLLV 2576
            D                      KV   G GL    +A V Q  +FTVDCS+AG   L V
Sbjct: 1443 D--------------------PGKVKCSGPGLGAGVRARVPQ--TFTVDCSQAGRAPLQV 1480

Query: 2577 GVHGPRTPCEEILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLV 2738
             V GP    E + V+  G   ++V Y     G YT+ VK+ D+ +P SP+++ V
Sbjct: 1481 AVLGPTGVAEPVEVRDNGDGTHTVHYTPATDGPYTVAVKYADQEVPRSPFKIKV 1534



 Score =  297 bits (760), Expect = 4e-80
 Identities = 247/895 (27%), Positives = 383/895 (42%), Gaps = 50/895 (5%)
 Frame = +3

Query: 204  GEITGEVRMPSGKVAQPAITDNKDG--TVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFY 377
            GE+   +  P G   +  +  N D   T  V Y P  AGLH++ + +   +I  SP +  
Sbjct: 309  GEVLVYIEDPEGHTEEAKVVPNNDKNRTYAVSYVPKVAGLHKVTVLFAGQNIERSPFEVN 368

Query: 378  VDYV--NCGHVTAYGPGLSH--GVVNKPAVFTVNTKDAGEGGLSLAIEGPS----KAEIS 533
            V     +   V+A GPGL     V NKP  F + T  AG G +++ I  P       E++
Sbjct: 369  VGMALGDANKVSARGPGLEPVGNVANKPTYFDIYTAGAGTGDVAVVIVDPQGRRDTVEVA 428

Query: 534  CTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARVT----------GDDSMRMS 683
              D  D T   +Y PV+ G +++ V +    I  SPF   V               ++  
Sbjct: 429  LEDKGDSTFRCTYRPVMEGPHTVHVAFAGAPITRSPFPVHVAEACNPNACRASGRGLQPK 488

Query: 684  HLKVGSAADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLV 863
             ++V   AD  +         L  TV  P G EEP  ++   +G     + P   G+++V
Sbjct: 489  GVRVKEVADFKVFTKGAGSGELKVTVKGPRGTEEPVKVREAGDGVFECEYYPVVPGKYVV 548

Query: 864  HVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEGHTFEPAEFIIDTRDAGYGGLS 1043
             +   G  +  SP  V +S        +VR  G GL  G   + A+F+++      G L 
Sbjct: 549  TITWGGYAIPRSPFEVQVSPE--AGIQKVRAWGPGLETGQVGKSADFVVEAIGTEVGTLG 606

Query: 1044 LSIEGPSKVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTGEGRVK 1223
             SIEGPS+  I  +D  DG+C V Y PTEPG Y +++   D+ +  SPF   +  +    
Sbjct: 607  FSIEGPSQAKIECDDKGDGSCDVRYWPTEPGEYAVHVICDDEDIRDSPFIAHI--QPAPP 664

Query: 1224 ESITRRQRA------PSVANVGSHCDLSLKIPEISIQDMTAQVTSPSGKSHEAEIVEGEN 1385
            +    + +A      P+   V    + ++        D+        G   + +++   +
Sbjct: 665  DCFPDKVKAFGPGLEPTGCIVDKPAEFTIDARAAGKGDLKLYAQDADGCPIDIKVIPNGD 724

Query: 1386 HTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAH--KVRAGGPGLERA-- 1553
             T+   +VP +   HT+ V + G +VP SPF+  VG     G+H  +V+  GPG+E+   
Sbjct: 725  GTFRCSYVPTKPIKHTIIVSWGGVNVPKSPFRVNVGE----GSHPERVKVYGPGVEKTGL 780

Query: 1554 EAGVPAEFSIWTREAGAGGLAIAVE------GPSKAEISFEDRK--DGSCGVAYVVQEPG 1709
            +A  P  F++   EAG G ++I ++      GP++A+I F+  K  + +  V Y     G
Sbjct: 781  KANEPTYFTVDCSEAGQGDVSIGIKCAPGVVGPAEADIDFDIIKNDNDTFTVKYTPPGAG 840

Query: 1710 DYEVSVKFNEEHIPDSPFVVPVASPSGDARRLTVS--SLQESGLKVNQPASFAVSLNGAK 1883
             Y + V F  + IP SPF + V  PS DA ++      L  +G++V +P  F V   GA 
Sbjct: 841  RYTIMVLFANQEIPASPFHIKV-DPSHDASKVKAEGPGLNRTGVEVGKPTHFTVLTKGA- 898

Query: 1884 GAIDAKVH----SPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFK 2051
            G     VH    +   A+ +  + +     Y V++   + G   + V + G  +P SPF 
Sbjct: 899  GKAKLDVHFAGAAKGEAVRDFEIIDNHDYSYTVKYTAVQQGNMAVTVTYGGDPVPKSPFV 958

Query: 2052 IRVGEPGHGGDPGLVSAYGAGLEGGVTGSPAEFIVNTSNAGA-GALSVTIDGPSKVKMDC 2228
            + V  P    D   V   G   +  V G    F VNT  AG  G L V +  PS+  + C
Sbjct: 959  VNVAPP---LDLSKVKVQGLNSKVAV-GQEQAFSVNTRGAGGQGQLDVRMTSPSRRPIPC 1014

Query: 2229 QECPEG----YRVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSS 2396
            +  P G      V Y P   G Y + I Y G + + GSPF                    
Sbjct: 1015 KLEPGGGAETQAVRYMPPEEGPYKVDITYDG-HPVPGSPFAVE----------------- 1056

Query: 2397 VFVDSLTKTXXXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKAGNNMLLV 2576
                                     SKV A G GL    VG    F++D   AG   L +
Sbjct: 1057 ------------------GVLPPDPSKVCAYGPGLKGGLVGTPAPFSIDTKGAGTGGLGL 1098

Query: 2577 GVHGPRTPCE-EILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLV 2738
             V G   PCE +I  +  G    +VSYL  + GEYT+ + + + HIPGSP++  +
Sbjct: 1099 TVEG---PCEAKIECQDNGDGSCAVSYLPTEPGEYTINILFAEAHIPGSPFKATI 1150



 Score =  278 bits (710), Expect = 3e-74
 Identities = 245/873 (28%), Positives = 376/873 (43%), Gaps = 40/873 (4%)
 Frame = +3

Query: 264  DNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFYVDYV--NC--GHVTAYGPGLSH 431
            D  DG+  VRY P+E G + + +  D+  I  SP   ++     +C    V A+GPGL  
Sbjct: 621  DKGDGSCDVRYWPTEPGEYAVHVICDDEDIRDSPFIAHIQPAPPDCFPDKVKAFGPGLEP 680

Query: 432  G--VVNKPAVFTVNTKDAGEGGLSLAIEGPSKA--EISCTDNQDGTCSVSYLPVLPGDYS 599
               +V+KPA FT++ + AG+G L L  +       +I    N DGT   SY+P  P  ++
Sbjct: 681  TGCIVDKPAEFTIDARAAGKGDLKLYAQDADGCPIDIKVIPNGDGTFRCSYVPTKPIKHT 740

Query: 600  ILVKYNEQHIPGSPFTARVTGDDS-----------MRMSHLKVGSAADIPINISET---D 737
            I+V +   ++P SPF   V G+ S           +  + LK        ++ SE    D
Sbjct: 741  IIVSWGGVNVPKSPFRVNV-GEGSHPERVKVYGPGVEKTGLKANEPTYFTVDCSEAGQGD 799

Query: 738  LSL---LTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNGQHVASSPIP 908
            +S+       VV P+  +    + +  N    + + P   G + + V    Q + +SP  
Sbjct: 800  VSIGIKCAPGVVGPAEADIDFDIIKNDNDTFTVKYTPPGAGRYTIMVLFANQEIPASPFH 859

Query: 909  VVISQSEIGDASRVRVSGRGLHEG--HTFEPAEFIIDTRDAGYGGLSLSIEGPSKV---- 1070
            + +  S   DAS+V+  G GL+       +P  F + T+ AG   L +   G +K     
Sbjct: 860  IKVDPSH--DASKVKAEGPGLNRTGVEVGKPTHFTVLTKGAGKAKLDVHFAGAAKGEAVR 917

Query: 1071 DINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTGEGRVKESITRRQRA 1250
            D    D  D +  V Y   + GN  + + +    VP SPF V V     +  S  + Q  
Sbjct: 918  DFEIIDNHDYSYTVKYTAVQQGNMAVTVTYGGDPVPKSPFVVNVAPP--LDLSKVKVQGL 975

Query: 1251 PSVANVGSHCDLSLKIPEISIQ-DMTAQVTSPSGKSHEAEIVEGEN-HTYCIRFVPAEMG 1424
             S   VG     S+       Q  +  ++TSPS +    ++  G    T  +R++P E G
Sbjct: 976  NSKVAVGQEQAFSVNTRGAGGQGQLDVRMTSPSRRPIPCKLEPGGGAETQAVRYMPPEEG 1035

Query: 1425 MHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLERAEAGVPAEFSIWTREAGA 1604
             + V + Y G  VPGSPF   V  +      KV A GPGL+    G PA FSI T+ AG 
Sbjct: 1036 PYKVDITYDGHPVPGSPF--AVEGVLPPDPSKVCAYGPGLKGGLVGTPAPFSIDTKGAGT 1093

Query: 1605 GGLAIAVEGPSKAEISFEDRKDGSCGVAYVVQEPGDYEVSVKFNEEHIPDSPFVVPVASP 1784
            GGL + VEGP +A+I  +D  DGSC V+Y+  EPG+Y +++ F E HIP SPF   +  P
Sbjct: 1094 GGLGLTVEGPCEAKIECQDNGDGSCAVSYLPTEPGEYTINILFAEAHIPGSPFKATI-RP 1152

Query: 1785 SGDARRLTVSSLQESGLKVNQPASFAVSLNGA-KGAIDAKVHSPSGALEECYVTEIDQDK 1961
              D  ++  S       K  + A+F V  + A +  +  ++ S +G   E  +       
Sbjct: 1153 VFDPSKVRASGPGLERGKAGEAATFTVDCSEAGEAELTIEILSDAGVKAEVLIHNNADGT 1212

Query: 1962 YAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPGLVSAYGAGLEGGVTGSP 2141
            Y + + P   G Y I +K+ G  +P  P ++ V +P        VS  G    G +    
Sbjct: 1213 YHITYSPAFPGTYTITIKYGGHPVPKFPTRVHV-QPAVDTSGVKVSGPGVEPHGVLREVT 1271

Query: 2142 AEFIVNTSN---AGAGALSVTIDGPSKVKMDCQECPEG---YRVTYTPMAPGSYLISIKY 2303
             EF V+  +    G   ++  +  PS  K D      G   YRV YT    G++L+ + Y
Sbjct: 1272 TEFTVDARSLTATGGNHVTARVLNPSGAKTDTYVTDNGDGTYRVQYTAYEEGAHLVEVLY 1331

Query: 2304 GGPYHIGGSPFKARVTGHRLVSNHSLHETSSVFVDSLTKTXXXXXXXXXXXXXXXXSKVL 2483
                 +  SPF+  VT                                        ++V 
Sbjct: 1332 -DDVAVPKSPFRVGVT-----------------------------------EGCDPTRVR 1355

Query: 2484 AKGLGLSKAYVGQKGSFTVDCSKAGNNMLLVGVHGPRTPCEEILVKHVGSRLYSVSYLLK 2663
            A G GL    V +   FTV+   AG   L + + GP            GS   +V Y+  
Sbjct: 1356 AFGPGLEGGLVNKANRFTVETRGAGTGGLGLAIEGPSEAKMSCKDNKDGS--CTVEYIPF 1413

Query: 2664 DKGEYTLVVKWGDEHIPGSPYRVLVP*ALCPGQ 2762
              G+Y + + +G   IPGSP+RV V   + PG+
Sbjct: 1414 TPGDYDVNITFGGRPIPGSPFRVPVKDVVDPGK 1446



 Score =  273 bits (697), Expect = 9e-73
 Identities = 172/478 (35%), Positives = 241/478 (50%), Gaps = 50/478 (10%)
 Frame = +3

Query: 207  EITGEVRMPSGKVAQPAITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFYVDY 386
            ++T +V  PSGK     I + +D   +VR+ P E G H + ++Y   H+PGSP QF V  
Sbjct: 2217 DMTAQVTSPSGKTEAAEIVEGEDSAYSVRFVPQEMGPHTVTVKYRGQHVPGSPFQFTVGP 2276

Query: 387  VNCG---HVTAYGPGLSHGVVNKPAVFTVNTKDAGEGGLSLAIEGPSKAEISCTDNQDGT 557
            +  G    V A G GL  GV   PA F++ T++AG GGLS+A+EGPSKAEI+  D +DG+
Sbjct: 2277 LGEGGAHKVRAGGTGLERGVAGVPAEFSIWTREAGAGGLSIAVEGPSKAEIAFEDRKDGS 2336

Query: 558  CSVSYLPVLPGDYSILVKYNEQHIPGSPFTARVTG--DDSMRMS-------HLKVGSAAD 710
            C VSY+   PGDY + +K+N++HIP SPF   V    DD+ R++        LKV   A 
Sbjct: 2337 CGVSYVVQEPGDYEVSIKFNDEHIPDSPFVVPVASLSDDARRLTVTSLQETGLKVNQPAS 2396

Query: 711  IPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNGQHV 890
              + ++     ++ A V  PSG  E C +  L +    I F+P E G H + VK NG H+
Sbjct: 2397 FAVQLNGAR-GVIDARVHTPSGAVEECYVSELDSDKHTIRFIPHENGVHSIDVKFNGAHI 2455

Query: 891  ASSPIPVVIS-QSEIGDASRVRVSGRGLHEGHTFEPAEFIIDTRDAGYGGLSLSIEGPSK 1067
              SP  + +  QS+ GD   V   G GL  G T   +EFI++T +AG G LS++I+GPSK
Sbjct: 2456 PGSPFKIRVGEQSQAGDPGLVSAYGPGLEGGTTGVSSEFIVNTLNAGSGALSVTIDGPSK 2515

Query: 1068 VDINTEDLEDGTCRVTYCPTEPGNYIINIKF-ADQHVPGSPFSVKVTG------------ 1208
            V ++  +  +G   VTY P  PGNY+I IK+   QH+ GSPF  KVTG            
Sbjct: 2516 VQLDCRECPEGHV-VTYTPMAPGNYLIAIKYGGPQHIVGSPFKAKVTGPRLSGGHSLHET 2574

Query: 1209 -----EGRVKESITRRQ-----------------RAP--SVANVGSHCDLSLKIPEISIQ 1316
                 E   K S +R                   R P  S A VG     ++   +    
Sbjct: 2575 STVLVETVTKSSSSRGSSYSSIPKFSSDASKVVTRGPGLSQAFVGQKNSFTVDCSKAGTN 2634

Query: 1317 DMTAQVTSPSGKSHEAEIVEGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTV 1490
             M   V  P     E  +    N  Y + +   E G + + VK+  + VPGSPF+  V
Sbjct: 2635 MMMVGVHGPKTPCEEVYVKHMGNRVYNVTYTVKEKGDYILIVKWGDESVPGSPFKVNV 2692



 Score =  234 bits (596), Expect = 5e-61
 Identities = 236/840 (28%), Positives = 368/840 (43%), Gaps = 47/840 (5%)
 Frame = +3

Query: 354  PGSPLQFYVDYVNCGHVTAYGPGLSH--GVVNKPAVFTVNTKDAGEGGLSLAIEGP---- 515
            PG+P++     +N     AYGPG+      V +PA FTV T DAG G + + IE P    
Sbjct: 265  PGAPVRS--KQLNPKKAIAYGPGIEPQGNTVLQPAHFTVQTVDAGIGEVLVYIEDPEGHT 322

Query: 516  SKAEISCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARV---TGDD---SMR 677
             +A++   ++++ T +VSY+P + G + + V +  Q+I  SPF   V    GD    S R
Sbjct: 323  EEAKVVPNNDKNRTYAVSYVPKVAGLHKVTVLFAGQNIERSPFEVNVGMALGDANKVSAR 382

Query: 678  MSHLK-VGSAADIP----INISETDLSLLTATVVPPSGREE--PCLLKRLRNGHVGISFV 836
               L+ VG+ A+ P    I  +      +   +V P GR +     L+   +     ++ 
Sbjct: 383  GPGLEPVGNVANKPTYFDIYTAGAGTGDVAVVIVDPQGRRDTVEVALEDKGDSTFRCTYR 442

Query: 837  PKETGEHLVHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEG--HTFEPAEFII 1010
            P   G H VHV   G  +  SP PV +  +E  + +  R SGRGL        E A+F +
Sbjct: 443  PVMEGPHTVHVAFAGAPITRSPFPVHV--AEACNPNACRASGRGLQPKGVRVKEVADFKV 500

Query: 1011 DTRDAGYGGLSLSIEGP--SKVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGS 1184
             T+ AG G L ++++GP  ++  +   +  DG     Y P  PG Y++ I +    +P S
Sbjct: 501  FTKGAGSGELKVTVKGPRGTEEPVKVREAGDGVFECEYYPVVPGKYVVTITWGGYAIPRS 560

Query: 1185 PFSVKVTGEGRVKESITRRQRAPSV--ANVGSHCDLSLKIPEISIQDMTAQVTSPSGKSH 1358
            PF V+V+ E  +++    R   P +    VG   D  ++     +  +   +  PS    
Sbjct: 561  PFEVQVSPEAGIQKV---RAWGPGLETGQVGKSADFVVEAIGTEVGTLGFSIEGPSQAKI 617

Query: 1359 EAEIVEGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPL-GEGGAHKVRAGG 1535
            E +  +  + +  +R+ P E G + V V    + +  SPF   + P   +    KV+A G
Sbjct: 618  ECD--DKGDGSCDVRYWPTEPGEYAVHVICDDEDIRDSPFIAHIQPAPPDCFPDKVKAFG 675

Query: 1536 PGLERAEAGV--PAEFSIWTREAGAGGLAIAVEGPSKAEISFE--DRKDGSCGVAYVVQE 1703
            PGLE     V  PAEF+I  R AG G L +  +      I  +     DG+   +YV  +
Sbjct: 676  PGLEPTGCIVDKPAEFTIDARAAGKGDLKLYAQDADGCPIDIKVIPNGDGTFRCSYVPTK 735

Query: 1704 PGDYEVSVKFNEEHIPDSPFVVPVASPSGDAR-RLTVSSLQESGLKVNQPASFAVSLNGA 1880
            P  + + V +   ++P SPF V V   S   R ++    ++++GLK N+P  F V  + A
Sbjct: 736  PIKHTIIVSWGGVNVPKSPFRVNVGEGSHPERVKVYGPGVEKTGLKANEPTYFTVDCSEA 795

Query: 1881 -KGAIDAKVH------SPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPG 2039
             +G +   +        P+ A  +  + + D D + V++ P   G Y I V F    IP 
Sbjct: 796  GQGDVSIGIKCAPGVVGPAEADIDFDIIKNDNDTFTVKYTPPGAGRYTIMVLFANQEIPA 855

Query: 2040 SPFKIRVGEPGHGGDPGLVSAYGAGLE--GGVTGSPAEFIVNTSNAGAGALSVTIDGPSK 2213
            SPF I+V +P H  D   V A G GL   G   G P  F V T  AG   L V   G +K
Sbjct: 856  SPFHIKV-DPSH--DASKVKAEGPGLNRTGVEVGKPTHFTVLTKGAGKAKLDVHFAGAAK 912

Query: 2214 VKM-----DCQECPEGYRVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHS 2378
             +              Y V YT +  G+  +++ YGG   +  SPF   V          
Sbjct: 913  GEAVRDFEIIDNHDYSYTVKYTAVQQGNMAVTVTYGGD-PVPKSPFVVNVA--------- 962

Query: 2379 LHETSSVFVDSLTKTXXXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKA- 2555
                                           SKV  +GL  SK  VGQ+ +F+V+   A 
Sbjct: 963  --------------------------PPLDLSKVKVQGLN-SKVAVGQEQAFSVNTRGAG 995

Query: 2556 GNNMLLVGVHGP-RTPCEEILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRV 2732
            G   L V +  P R P    L    G+   +V Y+  ++G Y + + +    +PGSP+ V
Sbjct: 996  GQGQLDVRMTSPSRRPIPCKLEPGGGAETQAVRYMPPEEGPYKVDITYDGHPVPGSPFAV 1055



 Score =  130 bits (328), Expect = 5e-30
 Identities = 91/311 (29%), Positives = 139/311 (44%), Gaps = 53/311 (17%)
 Frame = +3

Query: 138  VNGLDVTSLR---PFDLVIPFTIKKGEITGEVRMPSGKVAQPAITDNKDGTVTVRYAPSE 308
            V  L  T L+   P    +     +G I   V  PSG V +  +++      T+R+ P E
Sbjct: 2381 VTSLQETGLKVNQPASFAVQLNGARGVIDARVHTPSGAVEECYVSELDSDKHTIRFIPHE 2440

Query: 309  AGLHEMDIRYDNMHIPGSPLQFYVDYVNC----GHVTAYGPGLSHGVVNKPAVFTVNTKD 476
             G+H +D++++  HIPGSP +  V   +     G V+AYGPGL  G     + F VNT +
Sbjct: 2441 NGVHSIDVKFNGAHIPGSPFKIRVGEQSQAGDPGLVSAYGPGLEGGTTGVSSEFIVNTLN 2500

Query: 477  AGEGGLSLAIEGPSKAEISCTDNQDGTCSVSYLPVLPGDYSILVKY-NEQHIPGSPFTAR 653
            AG G LS+ I+GPSK ++ C +  +G   V+Y P+ PG+Y I +KY   QHI GSPF A+
Sbjct: 2501 AGSGALSVTIDGPSKVQLDCRECPEGHV-VTYTPMAPGNYLIAIKYGGPQHIVGSPFKAK 2559

Query: 654  VTG----------------------DDSMR-----------------------MSHLKVG 698
            VTG                        S R                       +S   VG
Sbjct: 2560 VTGPRLSGGHSLHETSTVLVETVTKSSSSRGSSYSSIPKFSSDASKVVTRGPGLSQAFVG 2619

Query: 699  SAADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKN 878
                  ++ S+   +++   V  P    E   +K + N    +++  KE G++++ VK  
Sbjct: 2620 QKNSFTVDCSKAGTNMMMVGVHGPKTPCEEVYVKHMGNRVYNVTYTVKEKGDYILIVKWG 2679

Query: 879  GQHVASSPIPV 911
             + V  SP  V
Sbjct: 2680 DESVPGSPFKV 2690


  Database: RefSeq49_BP.fasta
    Posted date:  Oct 17, 2011  1:42 PM
  Number of letters in database: 17,681,374
  Number of sequences in database:  33,088
  
Lambda     K      H
   0.318    0.134    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 33088
Number of Hits to DB: 124,711,678
Number of extensions: 3932763
Number of successful extensions: 24715
Number of sequences better than 1.0e-05: 11
Number of HSP's gapped: 22387
Number of HSP's successfully gapped: 116
Length of query: 1029
Length of database: 17,681,374
Length adjustment: 112
Effective length of query: 917
Effective length of database: 13,975,518
Effective search space: 12815550006
Effective search space used: 12815550006
Neighboring words threshold: 12
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 36 (18.5 bits)

BLASTX 2.2.24 [Aug-08-2010]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= 20110601C-007518
         (3088 letters)

Database: RefSeq49_CP.fasta 
           33,336 sequences; 18,874,504 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

Alignment   gi|XP_538205.2| PREDICTED: similar to Filamin A (Alpha-filamin)...  1758   0.0  
Alignment   gi|XP_867537.1| PREDICTED: similar to Filamin A (Alpha-filamin)...  1758   0.0  
Alignment   gi|XP_867483.1| PREDICTED: similar to Filamin A (Alpha-filamin)...  1758   0.0  
Alignment   gi|XP_867527.1| PREDICTED: similar to Filamin A (Alpha-filamin)...  1746   0.0  
Alignment   gi|XP_867545.1| PREDICTED: similar to Filamin A (Alpha-filamin)...  1715   0.0  
Alignment   gi|XP_867567.1| PREDICTED: similar to Filamin A (Alpha-filamin)...  1715   0.0  
Alignment   gi|XP_867555.1| PREDICTED: similar to Filamin A (Alpha-filamin)...  1715   0.0  
Alignment   gi|XP_867510.1| PREDICTED: similar to Filamin A (Alpha-filamin)...  1661   0.0  
Alignment   gi|XP_867520.1| PREDICTED: similar to Filamin A (Alpha-filamin)...  1549   0.0  
Alignment   gi|XP_858348.1| PREDICTED: similar to Filamin C (Gamma-filamin)...  1360   0.0  

>ref|XP_538205.2| PREDICTED: similar to Filamin A (Alpha-filamin) (Filamin 1)
            (Endothelial actin-binding protein) (Actin-binding
            protein 280) (ABP-280) (Nonmuscle filamin) isoform 1
            [Canis familiaris].
          Length = 2638

 Score = 1758 bits (4552), Expect = 0.0
 Identities = 871/913 (95%), Positives = 882/913 (96%)
 Frame = +3

Query: 3    PFQVTALAGEQPSVXXXXXXXXXXXXYTYAQGGQQTWAPERPLVGVNGLDVTSLRPFDLV 182
            PFQVTALAG+QP+             YTYAQGGQQTWAPERPL+GVNGLDVTSLRPFDLV
Sbjct: 1727 PFQVTALAGDQPAAQPPLRPQQLAPPYTYAQGGQQTWAPERPLMGVNGLDVTSLRPFDLV 1786

Query: 183  IPFTIKKGEITGEVRMPSGKVAQPAITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGS 362
            IPFTIKKGEITGEVRMPSGKVAQPAITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGS
Sbjct: 1787 IPFTIKKGEITGEVRMPSGKVAQPAITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGS 1846

Query: 363  PLQFYVDYVNCGHVTAYGPGLSHGVVNKPAVFTVNTKDAGEGGLSLAIEGPSKAEISCTD 542
            PLQFYVDYVNCGHVTAYGPGL+HGVVNKPAVFTVNTKDAGEGGLSLAIEGPSKAEISCTD
Sbjct: 1847 PLQFYVDYVNCGHVTAYGPGLTHGVVNKPAVFTVNTKDAGEGGLSLAIEGPSKAEISCTD 1906

Query: 543  NQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARVTGDDSMRMSHLKVGSAADIPIN 722
            NQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARVTGDDSMRMSHLKVGSAADIPIN
Sbjct: 1907 NQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARVTGDDSMRMSHLKVGSAADIPIN 1966

Query: 723  ISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNGQHVASSP 902
            ISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNGQHVASSP
Sbjct: 1967 ISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNGQHVASSP 2026

Query: 903  IPVVISQSEIGDASRVRVSGRGLHEGHTFEPAEFIIDTRDAGYGGLSLSIEGPSKVDINT 1082
            IPVVISQSEIGDASRVRVSG+GLHEGHTFEPAEFIIDTRDAGYGGLSLSIEGPSKVDINT
Sbjct: 2027 IPVVISQSEIGDASRVRVSGQGLHEGHTFEPAEFIIDTRDAGYGGLSLSIEGPSKVDINT 2086

Query: 1083 EDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTGEGRVKESITRRQRAPSVA 1262
            EDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTGEGRVKESITRR+RAPSVA
Sbjct: 2087 EDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTGEGRVKESITRRRRAPSVA 2146

Query: 1263 NVGSHCDLSLKIPEISIQDMTAQVTSPSGKSHEAEIVEGENHTYCIRFVPAEMGMHTVSV 1442
            NVGSHC+LSLKIPEISIQDMTAQVTSPSGK+HEAEIVEGENHTYCIRFVPAEMGMHTVSV
Sbjct: 2147 NVGSHCNLSLKIPEISIQDMTAQVTSPSGKTHEAEIVEGENHTYCIRFVPAEMGMHTVSV 2206

Query: 1443 KYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLERAEAGVPAEFSIWTREAGAGGLAIA 1622
            KYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLERAEAGVPAEFSIWTREAGAGGLAIA
Sbjct: 2207 KYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLERAEAGVPAEFSIWTREAGAGGLAIA 2266

Query: 1623 VEGPSKAEISFEDRKDGSCGVAYVVQEPGDYEVSVKFNEEHIPDSPFVVPVASPSGDARR 1802
            VEGPSKAEISFEDRKDGSCGVAYVVQEPGDYEVSVKFNEEHIPDSPFVVPVASPSGDARR
Sbjct: 2267 VEGPSKAEISFEDRKDGSCGVAYVVQEPGDYEVSVKFNEEHIPDSPFVVPVASPSGDARR 2326

Query: 1803 LTVSSLQESGLKVNQPASFAVSLNGAKGAIDAKVHSPSGALEECYVTEIDQDKYAVRFIP 1982
            LTVSSLQESGLKVNQPASFAVSLNGAKGAIDAKVHSPSGALEECYVTEIDQDKYAVRFIP
Sbjct: 2327 LTVSSLQESGLKVNQPASFAVSLNGAKGAIDAKVHSPSGALEECYVTEIDQDKYAVRFIP 2386

Query: 1983 RENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPGLVSAYGAGLEGGVTGSPAEFIVNT 2162
            RENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPGLVSAYGAGLEGGVTGSPAEFIVNT
Sbjct: 2387 RENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPGLVSAYGAGLEGGVTGSPAEFIVNT 2446

Query: 2163 SNAGAGALSVTIDGPSKVKMDCQECPEGYRVTYTPMAPGSYLISIKYGGPYHIGGSPFKA 2342
            SNAGAGALSVTIDGPSKVKMDCQECPEGYRVTYTPMAPGSYLISIKYGGPYHIGGSPFKA
Sbjct: 2447 SNAGAGALSVTIDGPSKVKMDCQECPEGYRVTYTPMAPGSYLISIKYGGPYHIGGSPFKA 2506

Query: 2343 RVTGHRLVSNHSLHETSSVFVDSLTKTXXXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQ 2522
            +VTG RLVSNHSLHETSSVFVDSLTKT                SKVLAKGLGLSKAYVGQ
Sbjct: 2507 KVTGPRLVSNHSLHETSSVFVDSLTKT-ASAPQHGALAGSTDASKVLAKGLGLSKAYVGQ 2565

Query: 2523 KGSFTVDCSKAGNNMLLVGVHGPRTPCEEILVKHVGSRLYSVSYLLKDKGEYTLVVKWGD 2702
            K SFTVDCSKAGNNMLLVGVHGPRTPCEEILVKHVG+RLY+VSYLLKDKGEYTLVVKWGD
Sbjct: 2566 KSSFTVDCSKAGNNMLLVGVHGPRTPCEEILVKHVGNRLYNVSYLLKDKGEYTLVVKWGD 2625

Query: 2703 EHIPGSPYRVLVP 2741
            EHIPGSPYRVLVP
Sbjct: 2626 EHIPGSPYRVLVP 2638



 Score =  429 bits (1102), Expect = e-119
 Identities = 282/877 (32%), Positives = 438/877 (49%), Gaps = 46/877 (5%)
 Frame = +3

Query: 246  AQPAITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFYV-DYVNCGHVTAYGPG 422
            A+ +  DNKDG+ +V Y P EAG + +++ Y    +PGSP +  V D  +   V   GPG
Sbjct: 1398 AKMSCMDNKDGSCSVEYIPYEAGTYSLNVTYGGHQVPGSPFKVPVHDVTDASKVKCSGPG 1457

Query: 423  LSHGVV--NKPAVFTVNTKDAGEGGLSLAIEGPSKA--EISCTDNQDGTCSVSYLPVLPG 590
            LS G+V  N P  F V+T  AG   L + ++GP      +   DN DGT +V+Y+P   G
Sbjct: 1458 LSPGMVRANLPQSFQVDTSKAGVAPLQVKVQGPKGLVEPVDVVDNADGTQTVNYVPSREG 1517

Query: 591  DYSILVKYNEQHIPGSPFTARV--TGDDS--------MRMSHLKVGSAADIPINISETDL 740
             YSI V Y E+ +P SPF  +V  T D S        +  + +      +  I+  +   
Sbjct: 1518 PYSISVLYGEEEVPRSPFKVKVLPTHDASKVKASGPGLNTTGVPASLPVEFTIDAKDAGE 1577

Query: 741  SLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNGQHVASSPIPVVIS 920
             LL   +  P G+ +   ++   +G   +++VP  TG + + +K  G  +  SP  V   
Sbjct: 1578 GLLAVQITDPEGKPKKTHIQDNHDGTYTVAYVPDVTGRYTILIKYGGDEIPFSPYRVRAV 1637

Query: 921  QSEIGDASRVRVSGRGLHEGHTFEPAE---FIIDTRDAGYGGLSLSIEGP--SKVDINTE 1085
             +  GDAS+  V+G G+  G T +  E     +DT+ AG G ++ ++  P  S+VD++  
Sbjct: 1638 PT--GDASKCTVTGAGI--GPTIQIGEETVITVDTKAAGKGKVTCTVCTPDGSEVDVDVV 1693

Query: 1086 DLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTG--EGRVKESITRRQRAPSV 1259
            + EDGT  + Y   +PG Y+I ++F  +HVP SPF V      +   +  +  +Q AP  
Sbjct: 1694 ENEDGTFDIFYTAPQPGKYVICVRFGGEHVPNSPFQVTALAGDQPAAQPPLRPQQLAPPY 1753

Query: 1260 A---------------------NVGSHCDLSLKIP-EISIQDMTAQVTSPSGKSHEAEIV 1373
                                  +V S     L IP  I   ++T +V  PSGK  +  I 
Sbjct: 1754 TYAQGGQQTWAPERPLMGVNGLDVTSLRPFDLVIPFTIKKGEITGEVRMPSGKVAQPAIT 1813

Query: 1374 EGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLERA 1553
            + ++ T  +R+ P+E G+H + ++Y   H+PGSP QF V  +  G    V A GPGL   
Sbjct: 1814 DNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFYVDYVNCG---HVTAYGPGLTHG 1870

Query: 1554 EAGVPAEFSIWTREAGAGGLAIAVEGPSKAEISFEDRKDGSCGVAYVVQEPGDYEVSVKF 1733
                PA F++ T++AG GGL++A+EGPSKAEIS  D +DG+C V+Y+   PGDY + VK+
Sbjct: 1871 VVNKPAVFTVNTKDAGEGGLSLAIEGPSKAEISCTDNQDGTCSVSYLPVLPGDYSILVKY 1930

Query: 1734 NEEHIPDSPFVVPVASPSGDARRLTVSSLQESGLKVNQPASFAVSLNGAK-GAIDAKVHS 1910
            NE+HIP SPF   V   +GD       S++ S LKV   A   ++++      + A V  
Sbjct: 1931 NEQHIPGSPFTARV---TGD------DSMRMSHLKVGSAADIPINISETDLSLLTATVVP 1981

Query: 1911 PSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPG 2090
            PSG  E C +  +      + F+P+E G +L+ VK NG H+  SP  + + +    GD  
Sbjct: 1982 PSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNGQHVASSPIPVVISQ-SEIGDAS 2040

Query: 2091 LVSAYGAGLEGGVTGSPAEFIVNTSNAGAGALSVTIDGPSKVKMDCQECPEG-YRVTYTP 2267
             V   G GL  G T  PAEFI++T +AG G LS++I+GPSKV ++ ++  +G  RVTY P
Sbjct: 2041 RVRVSGQGLHEGHTFEPAEFIIDTRDAGYGGLSLSIEGPSKVDINTEDLEDGTCRVTYCP 2100

Query: 2268 MAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSVFVDSLTKTXXXXXXXX 2447
              PG+Y+I+IK+    H+ GSPF  +VTG   V             +S+T+         
Sbjct: 2101 TEPGNYIINIKF-ADQHVPGSPFSVKVTGEGRVK------------ESITR--------- 2138

Query: 2448 XXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKAGNNMLLVGVHGPRTPCEEILVKHV 2627
                         +    S A VG   + ++   +     +   V  P     E  +   
Sbjct: 2139 -------------RRRAPSVANVGSHCNLSLKIPEISIQDMTAQVTSPSGKTHEAEIVEG 2185

Query: 2628 GSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLV 2738
             +  Y + ++  + G +T+ VK+  +H+PGSP++  V
Sbjct: 2186 ENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTV 2222



 Score =  347 bits (891), Expect = 3e-95
 Identities = 264/884 (29%), Positives = 409/884 (46%), Gaps = 39/884 (4%)
 Frame = +3

Query: 204  GEITGEVRMPSGK--VAQPAITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFY 377
            GE+   ++ P+G+    +P +    D T    Y P+  G+H + + +  + IP SP    
Sbjct: 414  GEVEVVIQDPTGQKGTVEPQLEARGDSTYRCSYQPTMEGVHTVHVTFAGVPIPRSPYTVT 473

Query: 378  VDYV-NCGHVTAYGPGLS-HGV-VNKPAVFTVNTKDAGEGGLSLAIEGPSKAE-ISCTDN 545
            V    N G   A G GL   GV V + A F V TK AG G L + ++GP   E +   D 
Sbjct: 474  VGQACNPGACRAVGRGLQPKGVRVKETADFKVYTKGAGSGDLKVTVKGPKGEERVKQKDL 533

Query: 546  QDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARV---TGDDSMR-----MSHLKVGS 701
             DG     Y P++PG Y++ + +  Q+I  SPF  +V    G+  +R     +    VG 
Sbjct: 534  GDGVYGFEYYPMVPGTYTVTITWGGQNIGRSPFEVKVGTECGNQKVRAWGPGLEGGVVGK 593

Query: 702  AADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNG 881
            +AD  +     D+  L  +V  PS  +  C  K   +G   + + P+E GE+ VHV  N 
Sbjct: 594  SADFVVEAIGDDVGTLGFSVEGPSQAKIECDDKG--DGSCDVRYWPQEAGEYAVHVLCNS 651

Query: 882  QHVASSPIPVVISQS-EIGDASRVRVSGRGLHEGHTF--EPAEFIIDTRDAGYGGLSLSI 1052
            + +  SP    I ++ +     RV+  G GL +      +PAEF +D +  G   L + +
Sbjct: 652  EDIRLSPFMADIREAPQDFHPDRVKARGPGLEKTGVAVNKPAEFTVDAKHGGKAALRVQV 711

Query: 1053 EGPS--KVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTGEGRVKE 1226
            +      VD   +D  +GT   +Y P +P  +   + +    +P SPF V V G G    
Sbjct: 712  QDNEGCPVDATVKDNGNGTYSCSYVPRKPVKHTAMVSWGGVSIPNSPFRVNV-GAGSHPN 770

Query: 1227 SITRRQRAPSVANVG--SHCDLSLKIP-------EISIQDMTAQ-VTSPSGKSHEAEIVE 1376
             +  +   P VA  G  +H      +        ++SI    A  V  P+    + +I+ 
Sbjct: 771  KV--KVYGPGVAKTGLKAHEPTYFTVDCTEAGQGDVSIGIKCAPGVVGPTEADIDFDIIR 828

Query: 1377 GENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLERA- 1553
             +N T+ +++ P   G +T+ V +  Q  P SP +  V P  +  A KV+A GPGL R  
Sbjct: 829  NDNDTFTVKYTPRGAGSYTIMVLFADQATPTSPIRVKVEPSHD--ASKVKAEGPGLSRTG 886

Query: 1554 -EAGVPAEFSIWTREAGAGGLAIAVEGPSKAE----ISFEDRKDGSCGVAYVVQEPGDYE 1718
             E G P  F+I  + AG G   +   G +K +    +   D  D +  V Y   + G   
Sbjct: 887  VELGKPTHFTINAKAAGKGKPDVQFSGLAKGDAVRDVDIIDHHDNTYTVKYTPVQQGPVG 946

Query: 1719 VSVKFNEEHIPDSPFVVPVASPSGDARRLTVSSLQESGLKVNQPASFAVSLNGA--KGAI 1892
            ++V +  + IP SPF V V SPS D  ++ VS L E  + V +   F V   GA  +G +
Sbjct: 947  INVTYGGDPIPKSPFSVGV-SPSLDLSKIKVSGLGEK-VDVGKDQEFTVKSKGAGGQGKV 1004

Query: 1893 DAKVHSPSGALEECYVTE-IDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEP 2069
             +K+  PSG    C V   +  D   VRF+PRE G Y ++V ++G  +PGSPF +    P
Sbjct: 1005 ASKITGPSGTAVPCKVEPGLGADNSVVRFVPREEGPYEVEVTYDGVPVPGSPFPVEALPP 1064

Query: 2070 GHGGDPGLVSAYGAGLEGGVTGSPAEFIVNTSNAGAGALSVTIDGPSKVKMDCQECPEGY 2249
                 P  V A+G GL+GG  GSPA F ++T  AG G L +T++GP + +++C +  +G 
Sbjct: 1065 TK---PSKVKAFGPGLQGGSAGSPARFTIDTKGAGMGGLGLTVEGPCEAQLECLDNGDGT 1121

Query: 2250 -RVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSVFVDSLTKTX 2426
              V+Y P  PG Y I+I +    HI GSPFKA V                          
Sbjct: 1122 CSVSYVPTEPGDYNINILFADT-HIPGSPFKAHVV------------------------- 1155

Query: 2427 XXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKAGNNMLLVGVHGPRTPCE 2606
                           SKV   G GL +A  G+ G F VDCS AG+  L + +        
Sbjct: 1156 ----------PCFDASKVKCSGPGLERATAGEAGQFHVDCSSAGSAELTIEIRSEAGLPA 1205

Query: 2607 EILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLV 2738
            E+ ++  G   ++++Y+    G YT+ +K+G + +P  P ++ V
Sbjct: 1206 EVHIQDHGDGTHTITYIPLCPGAYTVTIKYGGQPVPNFPSKLQV 1249



 Score =  318 bits (816), Expect = 2e-86
 Identities = 229/755 (30%), Positives = 359/755 (47%), Gaps = 38/755 (5%)
 Frame = +3

Query: 189  FTIK------KGEITGEVRMPSG-----KVAQPAITDNKDGTVTVRYAPSEAGLHEMDIR 335
            FT+K      +G++  ++  PSG     KV      DN      VR+ P E G +E+++ 
Sbjct: 991  FTVKSKGAGGQGKVASKITGPSGTAVPCKVEPGLGADNS----VVRFVPREEGPYEVEVT 1046

Query: 336  YDNMHIPGSPLQFY-VDYVNCGHVTAYGPGLSHGVVNKPAVFTVNTKDAGEGGLSLAIEG 512
            YD + +PGSP     +       V A+GPGL  G    PA FT++TK AG GGL L +EG
Sbjct: 1047 YDGVPVPGSPFPVEALPPTKPSKVKAFGPGLQGGSAGSPARFTIDTKGAGMGGLGLTVEG 1106

Query: 513  PSKAEISCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARVTG--DDSM---- 674
            P +A++ C DN DGTCSVSY+P  PGDY+I + + + HIPGSPF A V    D S     
Sbjct: 1107 PCEAQLECLDNGDGTCSVSYVPTEPGDYNINILFADTHIPGSPFKAHVVPCFDASKVKCS 1166

Query: 675  --RMSHLKVGSAADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKET 848
               +     G A    ++ S    + LT  +   +G      ++   +G   I+++P   
Sbjct: 1167 GPGLERATAGEAGQFHVDCSSAGSAELTIEIRSEAGLPAEVHIQDHGDGTHTITYIPLCP 1226

Query: 849  GEHLVHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEGHTFEPA--EFIIDTR- 1019
            G + V +K  GQ V + P  + +  +   D S V+  G G+     F  A  EF +D R 
Sbjct: 1227 GAYTVTIKYGGQPVPNFPSKLQVEPAV--DTSGVQCYGPGIEGQGVFREATTEFSVDARA 1284

Query: 1020 --DAGYGGLSLSIEGPS--KVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSP 1187
                G   +   +  PS    +   +D  DGT +V Y P E G + +++ +    VP SP
Sbjct: 1285 LTQTGGPHVKARVANPSGNLTETYVQDCGDGTYKVEYTPYEEGLHSVDVTYDGSPVPSSP 1344

Query: 1188 FSVKVTGEGRVKESITRRQRAPSVANVGSHCDLSLKIPEISIQDMTAQVTSPSGKSHEAE 1367
            F V VT EG     +                  +++        +   V  PS    +  
Sbjct: 1345 FQVPVT-EGCDPSRVRVHGPGIQSGTTNKPNKFTVETRGAGTGGLGLAVEGPS--EAKMS 1401

Query: 1368 IVEGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLE 1547
             ++ ++ +  + ++P E G ++++V Y G  VPGSPF+  V  + +  A KV+  GPGL 
Sbjct: 1402 CMDNKDGSCSVEYIPYEAGTYSLNVTYGGHQVPGSPFKVPVHDVTD--ASKVKCSGPGLS 1459

Query: 1548 --RAEAGVPAEFSIWTREAGAGGLAIAVEGPS--KAEISFEDRKDGSCGVAYVVQEPGDY 1715
                 A +P  F + T +AG   L + V+GP      +   D  DG+  V YV    G Y
Sbjct: 1460 PGMVRANLPQSFQVDTSKAGVAPLQVKVQGPKGLVEPVDVVDNADGTQTVNYVPSREGPY 1519

Query: 1716 EVSVKFNEEHIPDSPFVVPVASPSGDARRLTVS--SLQESGLKVNQPASFAVSLNGA-KG 1886
             +SV + EE +P SPF V V  P+ DA ++  S   L  +G+  + P  F +    A +G
Sbjct: 1520 SISVLYGEEEVPRSPFKVKVL-PTHDASKVKASGPGLNTTGVPASLPVEFTIDAKDAGEG 1578

Query: 1887 AIDAKVHSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGE 2066
             +  ++  P G  ++ ++ +     Y V ++P   G Y I +K+ G  IP SP+++R   
Sbjct: 1579 LLAVQITDPEGKPKKTHIQDNHDGTYTVAYVPDVTGRYTILIKYGGDEIPFSPYRVRAVP 1638

Query: 2067 PGHGGDPGLVSAYGAGLEGGV-TGSPAEFIVNTSNAGAGALSVTIDGP--SKVKMDCQEC 2237
                GD    +  GAG+   +  G      V+T  AG G ++ T+  P  S+V +D  E 
Sbjct: 1639 T---GDASKCTVTGAGIGPTIQIGEETVITVDTKAAGKGKVTCTVCTPDGSEVDVDVVEN 1695

Query: 2238 PEG-YRVTYTPMAPGSYLISIKYGGPYHIGGSPFK 2339
             +G + + YT   PG Y+I +++GG  H+  SPF+
Sbjct: 1696 EDGTFDIFYTAPQPGKYVICVRFGGE-HVPNSPFQ 1729



 Score =  286 bits (733), Expect = 6e-77
 Identities = 248/893 (27%), Positives = 386/893 (43%), Gaps = 47/893 (5%)
 Frame = +3

Query: 201  KGEITGEVRMPSGKVAQPAITDNKDG--TVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQF 374
            +GE+   V  P+G   +  +T N D   T +V Y P   G H++ + +   HI  SP + 
Sbjct: 313  QGEVLVYVEDPAGHQEEAKVTANNDKNRTFSVWYVPEVTGTHKVTVLFAGQHIAKSPFEV 372

Query: 375  YVD--YVNCGHVTAYGPGL--SHGVVNKPAVFTVNTKDAGEGGLSLAIEGPS----KAEI 530
            YVD    +   VTA GPGL  S  + NK   F + T  AG G + + I+ P+      E 
Sbjct: 373  YVDKSQGDASKVTAQGPGLEPSGNIANKTTYFEIFTAGAGTGEVEVVIQDPTGQKGTVEP 432

Query: 531  SCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARV----------TGDDSMRM 680
                  D T   SY P + G +++ V +    IP SP+T  V               ++ 
Sbjct: 433  QLEARGDSTYRCSYQPTMEGVHTVHVTFAGVPIPRSPYTVTVGQACNPGACRAVGRGLQP 492

Query: 681  SHLKVGSAADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHL 860
              ++V   AD  +         L  TV  P G EE    K L +G  G  + P   G + 
Sbjct: 493  KGVRVKETADFKVYTKGAGSGDLKVTVKGPKG-EERVKQKDLGDGVYGFEYYPMVPGTYT 551

Query: 861  VHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEGHTFEPAEFIIDTRDAGYGGL 1040
            V +   GQ++  SP  V +  +E G+  +VR  G GL  G   + A+F+++      G L
Sbjct: 552  VTITWGGQNIGRSPFEVKVG-TECGN-QKVRAWGPGLEGGVVGKSADFVVEAIGDDVGTL 609

Query: 1041 SLSIEGPSKVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTGEGRV 1220
              S+EGPS+  I  +D  DG+C V Y P E G Y +++    + +  SPF   +    + 
Sbjct: 610  GFSVEGPSQAKIECDDKGDGSCDVRYWPQEAGEYAVHVLCNSEDIRLSPFMADIREAPQD 669

Query: 1221 KESITRRQRAPSVANVG----SHCDLSLKIPEISIQDMTAQVTSPSGKSHEAEIVEGENH 1388
                  + R P +   G       + ++         +  QV    G   +A + +  N 
Sbjct: 670  FHPDRVKARGPGLEKTGVAVNKPAEFTVDAKHGGKAALRVQVQDNEGCPVDATVKDNGNG 729

Query: 1389 TYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAH--KVRAGGPGLERA--E 1556
            TY   +VP +   HT  V + G  +P SPF+  VG     G+H  KV+  GPG+ +   +
Sbjct: 730  TYSCSYVPRKPVKHTAMVSWGGVSIPNSPFRVNVG----AGSHPNKVKVYGPGVAKTGLK 785

Query: 1557 AGVPAEFSIWTREAGAGGLAIAVE------GPSKAEISFE--DRKDGSCGVAYVVQEPGD 1712
            A  P  F++   EAG G ++I ++      GP++A+I F+     + +  V Y  +  G 
Sbjct: 786  AHEPTYFTVDCTEAGQGDVSIGIKCAPGVVGPTEADIDFDIIRNDNDTFTVKYTPRGAGS 845

Query: 1713 YEVSVKFNEEHIPDSPFVVPVASPSGDARRLTVS--SLQESGLKVNQPASFAVSLNGA-K 1883
            Y + V F ++  P SP  V V  PS DA ++      L  +G+++ +P  F ++   A K
Sbjct: 846  YTIMVLFADQATPTSPIRVKV-EPSHDASKVKAEGPGLSRTGVELGKPTHFTINAKAAGK 904

Query: 1884 GAIDAKVH--SPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIR 2057
            G  D +    +   A+ +  + +   + Y V++ P + G   I+V + G  IP SPF + 
Sbjct: 905  GKPDVQFSGLAKGDAVRDVDIIDHHDNTYTVKYTPVQQGPVGINVTYGGDPIPKSPFSVG 964

Query: 2058 VGEPGHGGDPGLVSAYGAGLEGGVTGSPAEFIVNTSNAGA-GALSVTIDGPSKVKMDCQE 2234
            V       D   +   G G +  V G   EF V +  AG  G ++  I GPS   + C+ 
Sbjct: 965  VSP---SLDLSKIKVSGLGEKVDV-GKDQEFTVKSKGAGGQGKVASKITGPSGTAVPCKV 1020

Query: 2235 CP----EGYRVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSVF 2402
             P    +   V + P   G Y + + Y G   + GSPF                      
Sbjct: 1021 EPGLGADNSVVRFVPREEGPYEVEVTYDG-VPVPGSPFP--------------------- 1058

Query: 2403 VDSLTKTXXXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKAGNNMLLVGV 2582
            V++L  T                SKV A G GL     G    FT+D   AG   L + V
Sbjct: 1059 VEALPPT--------------KPSKVKAFGPGLQGGSAGSPARFTIDTKGAGMGGLGLTV 1104

Query: 2583 HGPRTPCE-EILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLV 2738
             G   PCE ++     G    SVSY+  + G+Y + + + D HIPGSP++  V
Sbjct: 1105 EG---PCEAQLECLDNGDGTCSVSYVPTEPGDYNINILFADTHIPGSPFKAHV 1154



 Score =  226 bits (577), Expect = 8e-59
 Identities = 230/843 (27%), Positives = 366/843 (43%), Gaps = 50/843 (5%)
 Frame = +3

Query: 354  PGSPLQFYVDYVNCGHVTAYGPGL--SHGVVNKPAVFTVNTKDAGEGGLSLAIEGPS--- 518
            PG+PL+     +N     AYGPG+  +  +V K A FTV T+ AG+G + + +E P+   
Sbjct: 271  PGAPLR---PKLNPKKARAYGPGIEPTGNMVKKRAEFTVETRSAGQGEVLVYVEDPAGHQ 327

Query: 519  -KAEISCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARV--TGDDSMRMSHL 689
             +A+++  ++++ T SV Y+P + G + + V +  QHI  SPF   V  +  D+ +++  
Sbjct: 328  EEAKVTANNDKNRTFSVWYVPEVTGTHKVTVLFAGQHIAKSPFEVYVDKSQGDASKVTAQ 387

Query: 690  KVGSAADIPINISETDLSLLTA---------TVVPPSGRE---EPCLLKRLRNGHVGISF 833
              G      I    T   + TA          +  P+G++   EP L  R  +     S+
Sbjct: 388  GPGLEPSGNIANKTTYFEIFTAGAGTGEVEVVIQDPTGQKGTVEPQLEAR-GDSTYRCSY 446

Query: 834  VPKETGEHLVHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEG--HTFEPAEFI 1007
             P   G H VHV   G  +  SP  V + Q+   +    R  GRGL        E A+F 
Sbjct: 447  QPTMEGVHTVHVTFAGVPIPRSPYTVTVGQA--CNPGACRAVGRGLQPKGVRVKETADFK 504

Query: 1008 IDTRDAGYGGLSLSIEGPSKVD-INTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGS 1184
            + T+ AG G L ++++GP   + +  +DL DG     Y P  PG Y + I +  Q++  S
Sbjct: 505  VYTKGAGSGDLKVTVKGPKGEERVKQKDLGDGVYGFEYYPMVPGTYTVTITWGGQNIGRS 564

Query: 1185 PFSVKVTGE-GRVKESITRRQRAPSVAN--VGSHCDLSLKIPEISIQDMTAQVTSPSGKS 1355
            PF VKV  E G  K     R   P +    VG   D  ++     +  +   V  PS   
Sbjct: 565  PFEVKVGTECGNQKV----RAWGPGLEGGVVGKSADFVVEAIGDDVGTLGFSVEGPSQAK 620

Query: 1356 HEAEIVEGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEG-GAHKVRAG 1532
             E +  +  + +  +R+ P E G + V V    + +  SPF   +    +     +V+A 
Sbjct: 621  IECD--DKGDGSCDVRYWPQEAGEYAVHVLCNSEDIRLSPFMADIREAPQDFHPDRVKAR 678

Query: 1533 GPGLERAEAGV--PAEFSIWTREAGAGGLAIAVEGPS--KAEISFEDRKDGSCGVAYVVQ 1700
            GPGLE+    V  PAEF++  +  G   L + V+       + + +D  +G+   +YV +
Sbjct: 679  GPGLEKTGVAVNKPAEFTVDAKHGGKAALRVQVQDNEGCPVDATVKDNGNGTYSCSYVPR 738

Query: 1701 EPGDYEVSVKFNEEHIPDSPFVVPVASPSGDAR-RLTVSSLQESGLKVNQPASFAVSLNG 1877
            +P  +   V +    IP+SPF V V + S   + ++    + ++GLK ++P  F V    
Sbjct: 739  KPVKHTAMVSWGGVSIPNSPFRVNVGAGSHPNKVKVYGPGVAKTGLKAHEPTYFTVDCTE 798

Query: 1878 A-KGAIDAKVH------SPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIP 2036
            A +G +   +        P+ A  +  +   D D + V++ PR  G Y I V F     P
Sbjct: 799  AGQGDVSIGIKCAPGVVGPTEADIDFDIIRNDNDTFTVKYTPRGAGSYTIMVLFADQATP 858

Query: 2037 GSPFKIRVGEPGHGGDPGLVSAYGAGLE--GGVTGSPAEFIVNTSNAGAGALSVTIDGPS 2210
             SP +++V EP H  D   V A G GL   G   G P  F +N   AG G   V   G +
Sbjct: 859  TSPIRVKV-EPSH--DASKVKAEGPGLSRTGVELGKPTHFTINAKAAGKGKPDVQFSGLA 915

Query: 2211 K----VKMDCQECPEG-YRVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNH 2375
            K      +D  +  +  Y V YTP+  G   I++ YGG   I  SPF   V+        
Sbjct: 916  KGDAVRDVDIIDHHDNTYTVKYTPVQQGPVGINVTYGGD-PIPKSPFSVGVS-------- 966

Query: 2376 SLHETSSVFVDSLTKTXXXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKA 2555
                                            SK+   GLG  K  VG+   FTV    A
Sbjct: 967  ---------------------------PSLDLSKIKVSGLG-EKVDVGKDQEFTVKSKGA 998

Query: 2556 GNN----MLLVGVHGPRTPCEEILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSP 2723
            G        + G  G   PC+  +   +G+    V ++ +++G Y + V +    +PGSP
Sbjct: 999  GGQGKVASKITGPSGTAVPCK--VEPGLGADNSVVRFVPREEGPYEVEVTYDGVPVPGSP 1056

Query: 2724 YRV 2732
            + V
Sbjct: 1057 FPV 1059


>ref|XP_867537.1| PREDICTED: similar to Filamin A (Alpha-filamin) (Filamin 1)
            (Endothelial actin-binding protein) (Actin-binding
            protein 280) (ABP-280) (Nonmuscle filamin) isoform 8
            [Canis familiaris].
          Length = 2623

 Score = 1758 bits (4552), Expect = 0.0
 Identities = 871/913 (95%), Positives = 882/913 (96%)
 Frame = +3

Query: 3    PFQVTALAGEQPSVXXXXXXXXXXXXYTYAQGGQQTWAPERPLVGVNGLDVTSLRPFDLV 182
            PFQVTALAG+QP+             YTYAQGGQQTWAPERPL+GVNGLDVTSLRPFDLV
Sbjct: 1712 PFQVTALAGDQPAAQPPLRPQQLAPPYTYAQGGQQTWAPERPLMGVNGLDVTSLRPFDLV 1771

Query: 183  IPFTIKKGEITGEVRMPSGKVAQPAITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGS 362
            IPFTIKKGEITGEVRMPSGKVAQPAITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGS
Sbjct: 1772 IPFTIKKGEITGEVRMPSGKVAQPAITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGS 1831

Query: 363  PLQFYVDYVNCGHVTAYGPGLSHGVVNKPAVFTVNTKDAGEGGLSLAIEGPSKAEISCTD 542
            PLQFYVDYVNCGHVTAYGPGL+HGVVNKPAVFTVNTKDAGEGGLSLAIEGPSKAEISCTD
Sbjct: 1832 PLQFYVDYVNCGHVTAYGPGLTHGVVNKPAVFTVNTKDAGEGGLSLAIEGPSKAEISCTD 1891

Query: 543  NQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARVTGDDSMRMSHLKVGSAADIPIN 722
            NQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARVTGDDSMRMSHLKVGSAADIPIN
Sbjct: 1892 NQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARVTGDDSMRMSHLKVGSAADIPIN 1951

Query: 723  ISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNGQHVASSP 902
            ISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNGQHVASSP
Sbjct: 1952 ISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNGQHVASSP 2011

Query: 903  IPVVISQSEIGDASRVRVSGRGLHEGHTFEPAEFIIDTRDAGYGGLSLSIEGPSKVDINT 1082
            IPVVISQSEIGDASRVRVSG+GLHEGHTFEPAEFIIDTRDAGYGGLSLSIEGPSKVDINT
Sbjct: 2012 IPVVISQSEIGDASRVRVSGQGLHEGHTFEPAEFIIDTRDAGYGGLSLSIEGPSKVDINT 2071

Query: 1083 EDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTGEGRVKESITRRQRAPSVA 1262
            EDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTGEGRVKESITRR+RAPSVA
Sbjct: 2072 EDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTGEGRVKESITRRRRAPSVA 2131

Query: 1263 NVGSHCDLSLKIPEISIQDMTAQVTSPSGKSHEAEIVEGENHTYCIRFVPAEMGMHTVSV 1442
            NVGSHC+LSLKIPEISIQDMTAQVTSPSGK+HEAEIVEGENHTYCIRFVPAEMGMHTVSV
Sbjct: 2132 NVGSHCNLSLKIPEISIQDMTAQVTSPSGKTHEAEIVEGENHTYCIRFVPAEMGMHTVSV 2191

Query: 1443 KYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLERAEAGVPAEFSIWTREAGAGGLAIA 1622
            KYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLERAEAGVPAEFSIWTREAGAGGLAIA
Sbjct: 2192 KYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLERAEAGVPAEFSIWTREAGAGGLAIA 2251

Query: 1623 VEGPSKAEISFEDRKDGSCGVAYVVQEPGDYEVSVKFNEEHIPDSPFVVPVASPSGDARR 1802
            VEGPSKAEISFEDRKDGSCGVAYVVQEPGDYEVSVKFNEEHIPDSPFVVPVASPSGDARR
Sbjct: 2252 VEGPSKAEISFEDRKDGSCGVAYVVQEPGDYEVSVKFNEEHIPDSPFVVPVASPSGDARR 2311

Query: 1803 LTVSSLQESGLKVNQPASFAVSLNGAKGAIDAKVHSPSGALEECYVTEIDQDKYAVRFIP 1982
            LTVSSLQESGLKVNQPASFAVSLNGAKGAIDAKVHSPSGALEECYVTEIDQDKYAVRFIP
Sbjct: 2312 LTVSSLQESGLKVNQPASFAVSLNGAKGAIDAKVHSPSGALEECYVTEIDQDKYAVRFIP 2371

Query: 1983 RENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPGLVSAYGAGLEGGVTGSPAEFIVNT 2162
            RENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPGLVSAYGAGLEGGVTGSPAEFIVNT
Sbjct: 2372 RENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPGLVSAYGAGLEGGVTGSPAEFIVNT 2431

Query: 2163 SNAGAGALSVTIDGPSKVKMDCQECPEGYRVTYTPMAPGSYLISIKYGGPYHIGGSPFKA 2342
            SNAGAGALSVTIDGPSKVKMDCQECPEGYRVTYTPMAPGSYLISIKYGGPYHIGGSPFKA
Sbjct: 2432 SNAGAGALSVTIDGPSKVKMDCQECPEGYRVTYTPMAPGSYLISIKYGGPYHIGGSPFKA 2491

Query: 2343 RVTGHRLVSNHSLHETSSVFVDSLTKTXXXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQ 2522
            +VTG RLVSNHSLHETSSVFVDSLTKT                SKVLAKGLGLSKAYVGQ
Sbjct: 2492 KVTGPRLVSNHSLHETSSVFVDSLTKT-ASAPQHGALAGSTDASKVLAKGLGLSKAYVGQ 2550

Query: 2523 KGSFTVDCSKAGNNMLLVGVHGPRTPCEEILVKHVGSRLYSVSYLLKDKGEYTLVVKWGD 2702
            K SFTVDCSKAGNNMLLVGVHGPRTPCEEILVKHVG+RLY+VSYLLKDKGEYTLVVKWGD
Sbjct: 2551 KSSFTVDCSKAGNNMLLVGVHGPRTPCEEILVKHVGNRLYNVSYLLKDKGEYTLVVKWGD 2610

Query: 2703 EHIPGSPYRVLVP 2741
            EHIPGSPYRVLVP
Sbjct: 2611 EHIPGSPYRVLVP 2623



 Score =  402 bits (1034), Expect = e-112
 Identities = 274/879 (31%), Positives = 425/879 (48%), Gaps = 48/879 (5%)
 Frame = +3

Query: 246  AQPAITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFYV-DYVNCGHVTAYGPG 422
            A+ +  DNKDG+ +V Y P EAG + +++ Y    +PGSP +  V D  +   V   GPG
Sbjct: 1398 AKMSCMDNKDGSCSVEYIPYEAGTYSLNVTYGGHQVPGSPFKVPVHDVTDASKVKCSGPG 1457

Query: 423  LSHGVV--NKPAVFTVNTKDAGEGGLSLAIEGPSKAEISCTDNQDGTCSVSYLPVLPGDY 596
            LS G+V  N P  F V+T  AG   L + ++GP                        G Y
Sbjct: 1458 LSPGMVRANLPQSFQVDTSKAGVAPLQVKVQGPKGDR-------------------EGPY 1498

Query: 597  SILVKYNEQHIPGSPFTARV--TGDDS--------MRMSHLKVGSAADIPINISETDLSL 746
            SI V Y E+ +P SPF  +V  T D S        +  + +      +  I+  +    L
Sbjct: 1499 SISVLYGEEEVPRSPFKVKVLPTHDASKVKASGPGLNTTGVPASLPVEFTIDAKDAGEGL 1558

Query: 747  LTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNGQHVASSPIPVVISQS 926
            L   +  P G+ +   ++   +G   +++VP  TG + + +K  G  +  SP  V    +
Sbjct: 1559 LAVQITDPEGKPKKTHIQDNHDGTYTVAYVPDVTGRYTILIKYGGDEIPFSPYRVRAVPT 1618

Query: 927  EIGDASR----VRVSGRGLHEGHTFEPAE---FIIDTRDAGYGGLSLSIEGP--SKVDIN 1079
              GDAS+    V + G GL +    E  E     +DT+ AG G ++ ++  P  S+VD++
Sbjct: 1619 --GDASKCTVTVSIGGHGLGKLEQLEVTEETVITVDTKAAGKGKVTCTVCTPDGSEVDVD 1676

Query: 1080 TEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTG--EGRVKESITRRQRAP 1253
              + EDGT  + Y   +PG Y+I ++F  +HVP SPF V      +   +  +  +Q AP
Sbjct: 1677 VVENEDGTFDIFYTAPQPGKYVICVRFGGEHVPNSPFQVTALAGDQPAAQPPLRPQQLAP 1736

Query: 1254 SVA---------------------NVGSHCDLSLKIP-EISIQDMTAQVTSPSGKSHEAE 1367
                                    +V S     L IP  I   ++T +V  PSGK  +  
Sbjct: 1737 PYTYAQGGQQTWAPERPLMGVNGLDVTSLRPFDLVIPFTIKKGEITGEVRMPSGKVAQPA 1796

Query: 1368 IVEGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLE 1547
            I + ++ T  +R+ P+E G+H + ++Y   H+PGSP QF V  +  G    V A GPGL 
Sbjct: 1797 ITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFYVDYVNCG---HVTAYGPGLT 1853

Query: 1548 RAEAGVPAEFSIWTREAGAGGLAIAVEGPSKAEISFEDRKDGSCGVAYVVQEPGDYEVSV 1727
                  PA F++ T++AG GGL++A+EGPSKAEIS  D +DG+C V+Y+   PGDY + V
Sbjct: 1854 HGVVNKPAVFTVNTKDAGEGGLSLAIEGPSKAEISCTDNQDGTCSVSYLPVLPGDYSILV 1913

Query: 1728 KFNEEHIPDSPFVVPVASPSGDARRLTVSSLQESGLKVNQPASFAVSLNGAK-GAIDAKV 1904
            K+NE+HIP SPF   V   +GD       S++ S LKV   A   ++++      + A V
Sbjct: 1914 KYNEQHIPGSPFTARV---TGD------DSMRMSHLKVGSAADIPINISETDLSLLTATV 1964

Query: 1905 HSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGD 2084
              PSG  E C +  +      + F+P+E G +L+ VK NG H+  SP  + + +    GD
Sbjct: 1965 VPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNGQHVASSPIPVVISQ-SEIGD 2023

Query: 2085 PGLVSAYGAGLEGGVTGSPAEFIVNTSNAGAGALSVTIDGPSKVKMDCQECPEG-YRVTY 2261
               V   G GL  G T  PAEFI++T +AG G LS++I+GPSKV ++ ++  +G  RVTY
Sbjct: 2024 ASRVRVSGQGLHEGHTFEPAEFIIDTRDAGYGGLSLSIEGPSKVDINTEDLEDGTCRVTY 2083

Query: 2262 TPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSVFVDSLTKTXXXXXX 2441
             P  PG+Y+I+IK+    H+ GSPF  +VTG   V             +S+T+       
Sbjct: 2084 CPTEPGNYIINIKF-ADQHVPGSPFSVKVTGEGRVK------------ESITR------- 2123

Query: 2442 XXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKAGNNMLLVGVHGPRTPCEEILVK 2621
                           +    S A VG   + ++   +     +   V  P     E  + 
Sbjct: 2124 ---------------RRRAPSVANVGSHCNLSLKIPEISIQDMTAQVTSPSGKTHEAEIV 2168

Query: 2622 HVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLV 2738
               +  Y + ++  + G +T+ VK+  +H+PGSP++  V
Sbjct: 2169 EGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTV 2207



 Score =  347 bits (891), Expect = 3e-95
 Identities = 264/884 (29%), Positives = 409/884 (46%), Gaps = 39/884 (4%)
 Frame = +3

Query: 204  GEITGEVRMPSGK--VAQPAITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFY 377
            GE+   ++ P+G+    +P +    D T    Y P+  G+H + + +  + IP SP    
Sbjct: 414  GEVEVVIQDPTGQKGTVEPQLEARGDSTYRCSYQPTMEGVHTVHVTFAGVPIPRSPYTVT 473

Query: 378  VDYV-NCGHVTAYGPGLS-HGV-VNKPAVFTVNTKDAGEGGLSLAIEGPSKAE-ISCTDN 545
            V    N G   A G GL   GV V + A F V TK AG G L + ++GP   E +   D 
Sbjct: 474  VGQACNPGACRAVGRGLQPKGVRVKETADFKVYTKGAGSGDLKVTVKGPKGEERVKQKDL 533

Query: 546  QDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARV---TGDDSMR-----MSHLKVGS 701
             DG     Y P++PG Y++ + +  Q+I  SPF  +V    G+  +R     +    VG 
Sbjct: 534  GDGVYGFEYYPMVPGTYTVTITWGGQNIGRSPFEVKVGTECGNQKVRAWGPGLEGGVVGK 593

Query: 702  AADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNG 881
            +AD  +     D+  L  +V  PS  +  C  K   +G   + + P+E GE+ VHV  N 
Sbjct: 594  SADFVVEAIGDDVGTLGFSVEGPSQAKIECDDKG--DGSCDVRYWPQEAGEYAVHVLCNS 651

Query: 882  QHVASSPIPVVISQS-EIGDASRVRVSGRGLHEGHTF--EPAEFIIDTRDAGYGGLSLSI 1052
            + +  SP    I ++ +     RV+  G GL +      +PAEF +D +  G   L + +
Sbjct: 652  EDIRLSPFMADIREAPQDFHPDRVKARGPGLEKTGVAVNKPAEFTVDAKHGGKAALRVQV 711

Query: 1053 EGPS--KVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTGEGRVKE 1226
            +      VD   +D  +GT   +Y P +P  +   + +    +P SPF V V G G    
Sbjct: 712  QDNEGCPVDATVKDNGNGTYSCSYVPRKPVKHTAMVSWGGVSIPNSPFRVNV-GAGSHPN 770

Query: 1227 SITRRQRAPSVANVG--SHCDLSLKIP-------EISIQDMTAQ-VTSPSGKSHEAEIVE 1376
             +  +   P VA  G  +H      +        ++SI    A  V  P+    + +I+ 
Sbjct: 771  KV--KVYGPGVAKTGLKAHEPTYFTVDCTEAGQGDVSIGIKCAPGVVGPTEADIDFDIIR 828

Query: 1377 GENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLERA- 1553
             +N T+ +++ P   G +T+ V +  Q  P SP +  V P  +  A KV+A GPGL R  
Sbjct: 829  NDNDTFTVKYTPRGAGSYTIMVLFADQATPTSPIRVKVEPSHD--ASKVKAEGPGLSRTG 886

Query: 1554 -EAGVPAEFSIWTREAGAGGLAIAVEGPSKAE----ISFEDRKDGSCGVAYVVQEPGDYE 1718
             E G P  F+I  + AG G   +   G +K +    +   D  D +  V Y   + G   
Sbjct: 887  VELGKPTHFTINAKAAGKGKPDVQFSGLAKGDAVRDVDIIDHHDNTYTVKYTPVQQGPVG 946

Query: 1719 VSVKFNEEHIPDSPFVVPVASPSGDARRLTVSSLQESGLKVNQPASFAVSLNGA--KGAI 1892
            ++V +  + IP SPF V V SPS D  ++ VS L E  + V +   F V   GA  +G +
Sbjct: 947  INVTYGGDPIPKSPFSVGV-SPSLDLSKIKVSGLGEK-VDVGKDQEFTVKSKGAGGQGKV 1004

Query: 1893 DAKVHSPSGALEECYVTE-IDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEP 2069
             +K+  PSG    C V   +  D   VRF+PRE G Y ++V ++G  +PGSPF +    P
Sbjct: 1005 ASKITGPSGTAVPCKVEPGLGADNSVVRFVPREEGPYEVEVTYDGVPVPGSPFPVEALPP 1064

Query: 2070 GHGGDPGLVSAYGAGLEGGVTGSPAEFIVNTSNAGAGALSVTIDGPSKVKMDCQECPEGY 2249
                 P  V A+G GL+GG  GSPA F ++T  AG G L +T++GP + +++C +  +G 
Sbjct: 1065 TK---PSKVKAFGPGLQGGSAGSPARFTIDTKGAGMGGLGLTVEGPCEAQLECLDNGDGT 1121

Query: 2250 -RVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSVFVDSLTKTX 2426
              V+Y P  PG Y I+I +    HI GSPFKA V                          
Sbjct: 1122 CSVSYVPTEPGDYNINILFADT-HIPGSPFKAHVV------------------------- 1155

Query: 2427 XXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKAGNNMLLVGVHGPRTPCE 2606
                           SKV   G GL +A  G+ G F VDCS AG+  L + +        
Sbjct: 1156 ----------PCFDASKVKCSGPGLERATAGEAGQFHVDCSSAGSAELTIEIRSEAGLPA 1205

Query: 2607 EILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLV 2738
            E+ ++  G   ++++Y+    G YT+ +K+G + +P  P ++ V
Sbjct: 1206 EVHIQDHGDGTHTITYIPLCPGAYTVTIKYGGQPVPNFPSKLQV 1249



 Score =  300 bits (767), Expect = 7e-81
 Identities = 224/756 (29%), Positives = 353/756 (46%), Gaps = 39/756 (5%)
 Frame = +3

Query: 189  FTIK------KGEITGEVRMPSG-----KVAQPAITDNKDGTVTVRYAPSEAGLHEMDIR 335
            FT+K      +G++  ++  PSG     KV      DN      VR+ P E G +E+++ 
Sbjct: 991  FTVKSKGAGGQGKVASKITGPSGTAVPCKVEPGLGADNS----VVRFVPREEGPYEVEVT 1046

Query: 336  YDNMHIPGSPLQFY-VDYVNCGHVTAYGPGLSHGVVNKPAVFTVNTKDAGEGGLSLAIEG 512
            YD + +PGSP     +       V A+GPGL  G    PA FT++TK AG GGL L +EG
Sbjct: 1047 YDGVPVPGSPFPVEALPPTKPSKVKAFGPGLQGGSAGSPARFTIDTKGAGMGGLGLTVEG 1106

Query: 513  PSKAEISCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARVTG--DDSM---- 674
            P +A++ C DN DGTCSVSY+P  PGDY+I + + + HIPGSPF A V    D S     
Sbjct: 1107 PCEAQLECLDNGDGTCSVSYVPTEPGDYNINILFADTHIPGSPFKAHVVPCFDASKVKCS 1166

Query: 675  --RMSHLKVGSAADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKET 848
               +     G A    ++ S    + LT  +   +G      ++   +G   I+++P   
Sbjct: 1167 GPGLERATAGEAGQFHVDCSSAGSAELTIEIRSEAGLPAEVHIQDHGDGTHTITYIPLCP 1226

Query: 849  GEHLVHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEGHTFEPA--EFIIDTR- 1019
            G + V +K  GQ V + P  + +  +   D S V+  G G+     F  A  EF +D R 
Sbjct: 1227 GAYTVTIKYGGQPVPNFPSKLQVEPAV--DTSGVQCYGPGIEGQGVFREATTEFSVDARA 1284

Query: 1020 --DAGYGGLSLSIEGPS--KVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSP 1187
                G   +   +  PS    +   +D  DGT +V Y P E G + +++ +    VP SP
Sbjct: 1285 LTQTGGPHVKARVANPSGNLTETYVQDCGDGTYKVEYTPYEEGLHSVDVTYDGSPVPSSP 1344

Query: 1188 FSVKVTGEGRVKESITRRQRAPSVANVGSHCDLSLKIPEISIQDMTAQVTSPSGKSHEAE 1367
            F V VT EG     +                  +++        +   V  PS    +  
Sbjct: 1345 FQVPVT-EGCDPSRVRVHGPGIQSGTTNKPNKFTVETRGAGTGGLGLAVEGPS--EAKMS 1401

Query: 1368 IVEGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLE 1547
             ++ ++ +  + ++P E G ++++V Y G  VPGSPF+  V  + +  A KV+  GPGL 
Sbjct: 1402 CMDNKDGSCSVEYIPYEAGTYSLNVTYGGHQVPGSPFKVPVHDVTD--ASKVKCSGPGLS 1459

Query: 1548 --RAEAGVPAEFSIWTREAGAGGLAIAVEGPSKAEISFEDRKDGSCGVAYVVQEPGDYEV 1721
                 A +P  F + T +AG   L + V+GP        DR+             G Y +
Sbjct: 1460 PGMVRANLPQSFQVDTSKAGVAPLQVKVQGPK------GDRE-------------GPYSI 1500

Query: 1722 SVKFNEEHIPDSPFVVPVASPSGDARRLTVS--SLQESGLKVNQPASFAVSLNGA-KGAI 1892
            SV + EE +P SPF V V  P+ DA ++  S   L  +G+  + P  F +    A +G +
Sbjct: 1501 SVLYGEEEVPRSPFKVKVL-PTHDASKVKASGPGLNTTGVPASLPVEFTIDAKDAGEGLL 1559

Query: 1893 DAKVHSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPG 2072
              ++  P G  ++ ++ +     Y V ++P   G Y I +K+ G  IP SP+++R    G
Sbjct: 1560 AVQITDPEGKPKKTHIQDNHDGTYTVAYVPDVTGRYTILIKYGGDEIPFSPYRVRAVPTG 1619

Query: 2073 HGGDPGL---VSAYGAG-LEGGVTGSPAEFIVNTSNAGAGALSVTIDGP--SKVKMDCQE 2234
                  +   +  +G G LE           V+T  AG G ++ T+  P  S+V +D  E
Sbjct: 1620 DASKCTVTVSIGGHGLGKLEQLEVTEETVITVDTKAAGKGKVTCTVCTPDGSEVDVDVVE 1679

Query: 2235 CPEG-YRVTYTPMAPGSYLISIKYGGPYHIGGSPFK 2339
              +G + + YT   PG Y+I +++GG  H+  SPF+
Sbjct: 1680 NEDGTFDIFYTAPQPGKYVICVRFGGE-HVPNSPFQ 1714



 Score =  286 bits (733), Expect = 6e-77
 Identities = 248/893 (27%), Positives = 386/893 (43%), Gaps = 47/893 (5%)
 Frame = +3

Query: 201  KGEITGEVRMPSGKVAQPAITDNKDG--TVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQF 374
            +GE+   V  P+G   +  +T N D   T +V Y P   G H++ + +   HI  SP + 
Sbjct: 313  QGEVLVYVEDPAGHQEEAKVTANNDKNRTFSVWYVPEVTGTHKVTVLFAGQHIAKSPFEV 372

Query: 375  YVD--YVNCGHVTAYGPGL--SHGVVNKPAVFTVNTKDAGEGGLSLAIEGPS----KAEI 530
            YVD    +   VTA GPGL  S  + NK   F + T  AG G + + I+ P+      E 
Sbjct: 373  YVDKSQGDASKVTAQGPGLEPSGNIANKTTYFEIFTAGAGTGEVEVVIQDPTGQKGTVEP 432

Query: 531  SCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARV----------TGDDSMRM 680
                  D T   SY P + G +++ V +    IP SP+T  V               ++ 
Sbjct: 433  QLEARGDSTYRCSYQPTMEGVHTVHVTFAGVPIPRSPYTVTVGQACNPGACRAVGRGLQP 492

Query: 681  SHLKVGSAADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHL 860
              ++V   AD  +         L  TV  P G EE    K L +G  G  + P   G + 
Sbjct: 493  KGVRVKETADFKVYTKGAGSGDLKVTVKGPKG-EERVKQKDLGDGVYGFEYYPMVPGTYT 551

Query: 861  VHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEGHTFEPAEFIIDTRDAGYGGL 1040
            V +   GQ++  SP  V +  +E G+  +VR  G GL  G   + A+F+++      G L
Sbjct: 552  VTITWGGQNIGRSPFEVKVG-TECGN-QKVRAWGPGLEGGVVGKSADFVVEAIGDDVGTL 609

Query: 1041 SLSIEGPSKVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTGEGRV 1220
              S+EGPS+  I  +D  DG+C V Y P E G Y +++    + +  SPF   +    + 
Sbjct: 610  GFSVEGPSQAKIECDDKGDGSCDVRYWPQEAGEYAVHVLCNSEDIRLSPFMADIREAPQD 669

Query: 1221 KESITRRQRAPSVANVG----SHCDLSLKIPEISIQDMTAQVTSPSGKSHEAEIVEGENH 1388
                  + R P +   G       + ++         +  QV    G   +A + +  N 
Sbjct: 670  FHPDRVKARGPGLEKTGVAVNKPAEFTVDAKHGGKAALRVQVQDNEGCPVDATVKDNGNG 729

Query: 1389 TYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAH--KVRAGGPGLERA--E 1556
            TY   +VP +   HT  V + G  +P SPF+  VG     G+H  KV+  GPG+ +   +
Sbjct: 730  TYSCSYVPRKPVKHTAMVSWGGVSIPNSPFRVNVG----AGSHPNKVKVYGPGVAKTGLK 785

Query: 1557 AGVPAEFSIWTREAGAGGLAIAVE------GPSKAEISFE--DRKDGSCGVAYVVQEPGD 1712
            A  P  F++   EAG G ++I ++      GP++A+I F+     + +  V Y  +  G 
Sbjct: 786  AHEPTYFTVDCTEAGQGDVSIGIKCAPGVVGPTEADIDFDIIRNDNDTFTVKYTPRGAGS 845

Query: 1713 YEVSVKFNEEHIPDSPFVVPVASPSGDARRLTVS--SLQESGLKVNQPASFAVSLNGA-K 1883
            Y + V F ++  P SP  V V  PS DA ++      L  +G+++ +P  F ++   A K
Sbjct: 846  YTIMVLFADQATPTSPIRVKV-EPSHDASKVKAEGPGLSRTGVELGKPTHFTINAKAAGK 904

Query: 1884 GAIDAKVH--SPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIR 2057
            G  D +    +   A+ +  + +   + Y V++ P + G   I+V + G  IP SPF + 
Sbjct: 905  GKPDVQFSGLAKGDAVRDVDIIDHHDNTYTVKYTPVQQGPVGINVTYGGDPIPKSPFSVG 964

Query: 2058 VGEPGHGGDPGLVSAYGAGLEGGVTGSPAEFIVNTSNAGA-GALSVTIDGPSKVKMDCQE 2234
            V       D   +   G G +  V G   EF V +  AG  G ++  I GPS   + C+ 
Sbjct: 965  VSP---SLDLSKIKVSGLGEKVDV-GKDQEFTVKSKGAGGQGKVASKITGPSGTAVPCKV 1020

Query: 2235 CP----EGYRVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSVF 2402
             P    +   V + P   G Y + + Y G   + GSPF                      
Sbjct: 1021 EPGLGADNSVVRFVPREEGPYEVEVTYDG-VPVPGSPFP--------------------- 1058

Query: 2403 VDSLTKTXXXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKAGNNMLLVGV 2582
            V++L  T                SKV A G GL     G    FT+D   AG   L + V
Sbjct: 1059 VEALPPT--------------KPSKVKAFGPGLQGGSAGSPARFTIDTKGAGMGGLGLTV 1104

Query: 2583 HGPRTPCE-EILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLV 2738
             G   PCE ++     G    SVSY+  + G+Y + + + D HIPGSP++  V
Sbjct: 1105 EG---PCEAQLECLDNGDGTCSVSYVPTEPGDYNINILFADTHIPGSPFKAHV 1154



 Score =  226 bits (577), Expect = 8e-59
 Identities = 230/843 (27%), Positives = 366/843 (43%), Gaps = 50/843 (5%)
 Frame = +3

Query: 354  PGSPLQFYVDYVNCGHVTAYGPGL--SHGVVNKPAVFTVNTKDAGEGGLSLAIEGPS--- 518
            PG+PL+     +N     AYGPG+  +  +V K A FTV T+ AG+G + + +E P+   
Sbjct: 271  PGAPLR---PKLNPKKARAYGPGIEPTGNMVKKRAEFTVETRSAGQGEVLVYVEDPAGHQ 327

Query: 519  -KAEISCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARV--TGDDSMRMSHL 689
             +A+++  ++++ T SV Y+P + G + + V +  QHI  SPF   V  +  D+ +++  
Sbjct: 328  EEAKVTANNDKNRTFSVWYVPEVTGTHKVTVLFAGQHIAKSPFEVYVDKSQGDASKVTAQ 387

Query: 690  KVGSAADIPINISETDLSLLTA---------TVVPPSGRE---EPCLLKRLRNGHVGISF 833
              G      I    T   + TA          +  P+G++   EP L  R  +     S+
Sbjct: 388  GPGLEPSGNIANKTTYFEIFTAGAGTGEVEVVIQDPTGQKGTVEPQLEAR-GDSTYRCSY 446

Query: 834  VPKETGEHLVHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEG--HTFEPAEFI 1007
             P   G H VHV   G  +  SP  V + Q+   +    R  GRGL        E A+F 
Sbjct: 447  QPTMEGVHTVHVTFAGVPIPRSPYTVTVGQA--CNPGACRAVGRGLQPKGVRVKETADFK 504

Query: 1008 IDTRDAGYGGLSLSIEGPSKVD-INTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGS 1184
            + T+ AG G L ++++GP   + +  +DL DG     Y P  PG Y + I +  Q++  S
Sbjct: 505  VYTKGAGSGDLKVTVKGPKGEERVKQKDLGDGVYGFEYYPMVPGTYTVTITWGGQNIGRS 564

Query: 1185 PFSVKVTGE-GRVKESITRRQRAPSVAN--VGSHCDLSLKIPEISIQDMTAQVTSPSGKS 1355
            PF VKV  E G  K     R   P +    VG   D  ++     +  +   V  PS   
Sbjct: 565  PFEVKVGTECGNQKV----RAWGPGLEGGVVGKSADFVVEAIGDDVGTLGFSVEGPSQAK 620

Query: 1356 HEAEIVEGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEG-GAHKVRAG 1532
             E +  +  + +  +R+ P E G + V V    + +  SPF   +    +     +V+A 
Sbjct: 621  IECD--DKGDGSCDVRYWPQEAGEYAVHVLCNSEDIRLSPFMADIREAPQDFHPDRVKAR 678

Query: 1533 GPGLERAEAGV--PAEFSIWTREAGAGGLAIAVEGPS--KAEISFEDRKDGSCGVAYVVQ 1700
            GPGLE+    V  PAEF++  +  G   L + V+       + + +D  +G+   +YV +
Sbjct: 679  GPGLEKTGVAVNKPAEFTVDAKHGGKAALRVQVQDNEGCPVDATVKDNGNGTYSCSYVPR 738

Query: 1701 EPGDYEVSVKFNEEHIPDSPFVVPVASPSGDAR-RLTVSSLQESGLKVNQPASFAVSLNG 1877
            +P  +   V +    IP+SPF V V + S   + ++    + ++GLK ++P  F V    
Sbjct: 739  KPVKHTAMVSWGGVSIPNSPFRVNVGAGSHPNKVKVYGPGVAKTGLKAHEPTYFTVDCTE 798

Query: 1878 A-KGAIDAKVH------SPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIP 2036
            A +G +   +        P+ A  +  +   D D + V++ PR  G Y I V F     P
Sbjct: 799  AGQGDVSIGIKCAPGVVGPTEADIDFDIIRNDNDTFTVKYTPRGAGSYTIMVLFADQATP 858

Query: 2037 GSPFKIRVGEPGHGGDPGLVSAYGAGLE--GGVTGSPAEFIVNTSNAGAGALSVTIDGPS 2210
             SP +++V EP H  D   V A G GL   G   G P  F +N   AG G   V   G +
Sbjct: 859  TSPIRVKV-EPSH--DASKVKAEGPGLSRTGVELGKPTHFTINAKAAGKGKPDVQFSGLA 915

Query: 2211 K----VKMDCQECPEG-YRVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNH 2375
            K      +D  +  +  Y V YTP+  G   I++ YGG   I  SPF   V+        
Sbjct: 916  KGDAVRDVDIIDHHDNTYTVKYTPVQQGPVGINVTYGGD-PIPKSPFSVGVS-------- 966

Query: 2376 SLHETSSVFVDSLTKTXXXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKA 2555
                                            SK+   GLG  K  VG+   FTV    A
Sbjct: 967  ---------------------------PSLDLSKIKVSGLG-EKVDVGKDQEFTVKSKGA 998

Query: 2556 GNN----MLLVGVHGPRTPCEEILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSP 2723
            G        + G  G   PC+  +   +G+    V ++ +++G Y + V +    +PGSP
Sbjct: 999  GGQGKVASKITGPSGTAVPCK--VEPGLGADNSVVRFVPREEGPYEVEVTYDGVPVPGSP 1056

Query: 2724 YRV 2732
            + V
Sbjct: 1057 FPV 1059


>ref|XP_867483.1| PREDICTED: similar to Filamin A (Alpha-filamin) (Filamin 1)
            (Endothelial actin-binding protein) (Actin-binding
            protein 280) (ABP-280) (Nonmuscle filamin) isoform 2
            [Canis familiaris].
          Length = 2646

 Score = 1758 bits (4552), Expect = 0.0
 Identities = 871/913 (95%), Positives = 882/913 (96%)
 Frame = +3

Query: 3    PFQVTALAGEQPSVXXXXXXXXXXXXYTYAQGGQQTWAPERPLVGVNGLDVTSLRPFDLV 182
            PFQVTALAG+QP+             YTYAQGGQQTWAPERPL+GVNGLDVTSLRPFDLV
Sbjct: 1735 PFQVTALAGDQPAAQPPLRPQQLAPPYTYAQGGQQTWAPERPLMGVNGLDVTSLRPFDLV 1794

Query: 183  IPFTIKKGEITGEVRMPSGKVAQPAITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGS 362
            IPFTIKKGEITGEVRMPSGKVAQPAITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGS
Sbjct: 1795 IPFTIKKGEITGEVRMPSGKVAQPAITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGS 1854

Query: 363  PLQFYVDYVNCGHVTAYGPGLSHGVVNKPAVFTVNTKDAGEGGLSLAIEGPSKAEISCTD 542
            PLQFYVDYVNCGHVTAYGPGL+HGVVNKPAVFTVNTKDAGEGGLSLAIEGPSKAEISCTD
Sbjct: 1855 PLQFYVDYVNCGHVTAYGPGLTHGVVNKPAVFTVNTKDAGEGGLSLAIEGPSKAEISCTD 1914

Query: 543  NQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARVTGDDSMRMSHLKVGSAADIPIN 722
            NQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARVTGDDSMRMSHLKVGSAADIPIN
Sbjct: 1915 NQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARVTGDDSMRMSHLKVGSAADIPIN 1974

Query: 723  ISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNGQHVASSP 902
            ISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNGQHVASSP
Sbjct: 1975 ISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNGQHVASSP 2034

Query: 903  IPVVISQSEIGDASRVRVSGRGLHEGHTFEPAEFIIDTRDAGYGGLSLSIEGPSKVDINT 1082
            IPVVISQSEIGDASRVRVSG+GLHEGHTFEPAEFIIDTRDAGYGGLSLSIEGPSKVDINT
Sbjct: 2035 IPVVISQSEIGDASRVRVSGQGLHEGHTFEPAEFIIDTRDAGYGGLSLSIEGPSKVDINT 2094

Query: 1083 EDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTGEGRVKESITRRQRAPSVA 1262
            EDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTGEGRVKESITRR+RAPSVA
Sbjct: 2095 EDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTGEGRVKESITRRRRAPSVA 2154

Query: 1263 NVGSHCDLSLKIPEISIQDMTAQVTSPSGKSHEAEIVEGENHTYCIRFVPAEMGMHTVSV 1442
            NVGSHC+LSLKIPEISIQDMTAQVTSPSGK+HEAEIVEGENHTYCIRFVPAEMGMHTVSV
Sbjct: 2155 NVGSHCNLSLKIPEISIQDMTAQVTSPSGKTHEAEIVEGENHTYCIRFVPAEMGMHTVSV 2214

Query: 1443 KYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLERAEAGVPAEFSIWTREAGAGGLAIA 1622
            KYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLERAEAGVPAEFSIWTREAGAGGLAIA
Sbjct: 2215 KYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLERAEAGVPAEFSIWTREAGAGGLAIA 2274

Query: 1623 VEGPSKAEISFEDRKDGSCGVAYVVQEPGDYEVSVKFNEEHIPDSPFVVPVASPSGDARR 1802
            VEGPSKAEISFEDRKDGSCGVAYVVQEPGDYEVSVKFNEEHIPDSPFVVPVASPSGDARR
Sbjct: 2275 VEGPSKAEISFEDRKDGSCGVAYVVQEPGDYEVSVKFNEEHIPDSPFVVPVASPSGDARR 2334

Query: 1803 LTVSSLQESGLKVNQPASFAVSLNGAKGAIDAKVHSPSGALEECYVTEIDQDKYAVRFIP 1982
            LTVSSLQESGLKVNQPASFAVSLNGAKGAIDAKVHSPSGALEECYVTEIDQDKYAVRFIP
Sbjct: 2335 LTVSSLQESGLKVNQPASFAVSLNGAKGAIDAKVHSPSGALEECYVTEIDQDKYAVRFIP 2394

Query: 1983 RENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPGLVSAYGAGLEGGVTGSPAEFIVNT 2162
            RENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPGLVSAYGAGLEGGVTGSPAEFIVNT
Sbjct: 2395 RENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPGLVSAYGAGLEGGVTGSPAEFIVNT 2454

Query: 2163 SNAGAGALSVTIDGPSKVKMDCQECPEGYRVTYTPMAPGSYLISIKYGGPYHIGGSPFKA 2342
            SNAGAGALSVTIDGPSKVKMDCQECPEGYRVTYTPMAPGSYLISIKYGGPYHIGGSPFKA
Sbjct: 2455 SNAGAGALSVTIDGPSKVKMDCQECPEGYRVTYTPMAPGSYLISIKYGGPYHIGGSPFKA 2514

Query: 2343 RVTGHRLVSNHSLHETSSVFVDSLTKTXXXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQ 2522
            +VTG RLVSNHSLHETSSVFVDSLTKT                SKVLAKGLGLSKAYVGQ
Sbjct: 2515 KVTGPRLVSNHSLHETSSVFVDSLTKT-ASAPQHGALAGSTDASKVLAKGLGLSKAYVGQ 2573

Query: 2523 KGSFTVDCSKAGNNMLLVGVHGPRTPCEEILVKHVGSRLYSVSYLLKDKGEYTLVVKWGD 2702
            K SFTVDCSKAGNNMLLVGVHGPRTPCEEILVKHVG+RLY+VSYLLKDKGEYTLVVKWGD
Sbjct: 2574 KSSFTVDCSKAGNNMLLVGVHGPRTPCEEILVKHVGNRLYNVSYLLKDKGEYTLVVKWGD 2633

Query: 2703 EHIPGSPYRVLVP 2741
            EHIPGSPYRVLVP
Sbjct: 2634 EHIPGSPYRVLVP 2646



 Score =  425 bits (1092), Expect = e-118
 Identities = 282/883 (31%), Positives = 436/883 (49%), Gaps = 52/883 (5%)
 Frame = +3

Query: 246  AQPAITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFYV-DYVNCGHVTAYGPG 422
            A+ +  DNKDG+ +V Y P EAG + +++ Y    +PGSP +  V D  +   V   GPG
Sbjct: 1398 AKMSCMDNKDGSCSVEYIPYEAGTYSLNVTYGGHQVPGSPFKVPVHDVTDASKVKCSGPG 1457

Query: 423  LSHGVV--NKPAVFTVNTKDAGEGGLSLAIEGPSKA--EISCTDNQDGTCSVSYLPVLPG 590
            LS G+V  N P  F V+T  AG   L + ++GP      +   DN DGT +V+Y+P   G
Sbjct: 1458 LSPGMVRANLPQSFQVDTSKAGVAPLQVKVQGPKGLVEPVDVVDNADGTQTVNYVPSREG 1517

Query: 591  DYSILVKYNEQHIPGSPFTARV--TGDDS--------MRMSHLKVGSAADIPINISETDL 740
             YSI V Y E+ +P SPF  +V  T D S        +  + +      +  I+  +   
Sbjct: 1518 PYSISVLYGEEEVPRSPFKVKVLPTHDASKVKASGPGLNTTGVPASLPVEFTIDAKDAGE 1577

Query: 741  SLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNGQHVASSPIPVVIS 920
             LL   +  P G+ +   ++   +G   +++VP  TG + + +K  G  +  SP  V   
Sbjct: 1578 GLLAVQITDPEGKPKKTHIQDNHDGTYTVAYVPDVTGRYTILIKYGGDEIPFSPYRVRAV 1637

Query: 921  QSEIGDASR----VRVSGRGLHEG-----HTFEPAEFIIDTRDAGYGGLSLSIEGP--SK 1067
             +  GDAS+    V + G GL  G        E     +DT+ AG G ++ ++  P  S+
Sbjct: 1638 PT--GDASKCTVTVSIGGHGLGAGIGPTIQIGEETVITVDTKAAGKGKVTCTVCTPDGSE 1695

Query: 1068 VDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTG--EGRVKESITRR 1241
            VD++  + EDGT  + Y   +PG Y+I ++F  +HVP SPF V      +   +  +  +
Sbjct: 1696 VDVDVVENEDGTFDIFYTAPQPGKYVICVRFGGEHVPNSPFQVTALAGDQPAAQPPLRPQ 1755

Query: 1242 QRAPSVA---------------------NVGSHCDLSLKIP-EISIQDMTAQVTSPSGKS 1355
            Q AP                        +V S     L IP  I   ++T +V  PSGK 
Sbjct: 1756 QLAPPYTYAQGGQQTWAPERPLMGVNGLDVTSLRPFDLVIPFTIKKGEITGEVRMPSGKV 1815

Query: 1356 HEAEIVEGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGG 1535
             +  I + ++ T  +R+ P+E G+H + ++Y   H+PGSP QF V  +  G    V A G
Sbjct: 1816 AQPAITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFYVDYVNCG---HVTAYG 1872

Query: 1536 PGLERAEAGVPAEFSIWTREAGAGGLAIAVEGPSKAEISFEDRKDGSCGVAYVVQEPGDY 1715
            PGL       PA F++ T++AG GGL++A+EGPSKAEIS  D +DG+C V+Y+   PGDY
Sbjct: 1873 PGLTHGVVNKPAVFTVNTKDAGEGGLSLAIEGPSKAEISCTDNQDGTCSVSYLPVLPGDY 1932

Query: 1716 EVSVKFNEEHIPDSPFVVPVASPSGDARRLTVSSLQESGLKVNQPASFAVSLNGAK-GAI 1892
             + VK+NE+HIP SPF   V   +GD       S++ S LKV   A   ++++      +
Sbjct: 1933 SILVKYNEQHIPGSPFTARV---TGD------DSMRMSHLKVGSAADIPINISETDLSLL 1983

Query: 1893 DAKVHSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPG 2072
             A V  PSG  E C +  +      + F+P+E G +L+ VK NG H+  SP  + + +  
Sbjct: 1984 TATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNGQHVASSPIPVVISQ-S 2042

Query: 2073 HGGDPGLVSAYGAGLEGGVTGSPAEFIVNTSNAGAGALSVTIDGPSKVKMDCQECPEG-Y 2249
              GD   V   G GL  G T  PAEFI++T +AG G LS++I+GPSKV ++ ++  +G  
Sbjct: 2043 EIGDASRVRVSGQGLHEGHTFEPAEFIIDTRDAGYGGLSLSIEGPSKVDINTEDLEDGTC 2102

Query: 2250 RVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSVFVDSLTKTXX 2429
            RVTY P  PG+Y+I+IK+    H+ GSPF  +VTG   V             +S+T+   
Sbjct: 2103 RVTYCPTEPGNYIINIKF-ADQHVPGSPFSVKVTGEGRVK------------ESITR--- 2146

Query: 2430 XXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKAGNNMLLVGVHGPRTPCEE 2609
                               +    S A VG   + ++   +     +   V  P     E
Sbjct: 2147 -------------------RRRAPSVANVGSHCNLSLKIPEISIQDMTAQVTSPSGKTHE 2187

Query: 2610 ILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLV 2738
              +    +  Y + ++  + G +T+ VK+  +H+PGSP++  V
Sbjct: 2188 AEIVEGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTV 2230



 Score =  347 bits (891), Expect = 3e-95
 Identities = 264/884 (29%), Positives = 409/884 (46%), Gaps = 39/884 (4%)
 Frame = +3

Query: 204  GEITGEVRMPSGK--VAQPAITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFY 377
            GE+   ++ P+G+    +P +    D T    Y P+  G+H + + +  + IP SP    
Sbjct: 414  GEVEVVIQDPTGQKGTVEPQLEARGDSTYRCSYQPTMEGVHTVHVTFAGVPIPRSPYTVT 473

Query: 378  VDYV-NCGHVTAYGPGLS-HGV-VNKPAVFTVNTKDAGEGGLSLAIEGPSKAE-ISCTDN 545
            V    N G   A G GL   GV V + A F V TK AG G L + ++GP   E +   D 
Sbjct: 474  VGQACNPGACRAVGRGLQPKGVRVKETADFKVYTKGAGSGDLKVTVKGPKGEERVKQKDL 533

Query: 546  QDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARV---TGDDSMR-----MSHLKVGS 701
             DG     Y P++PG Y++ + +  Q+I  SPF  +V    G+  +R     +    VG 
Sbjct: 534  GDGVYGFEYYPMVPGTYTVTITWGGQNIGRSPFEVKVGTECGNQKVRAWGPGLEGGVVGK 593

Query: 702  AADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNG 881
            +AD  +     D+  L  +V  PS  +  C  K   +G   + + P+E GE+ VHV  N 
Sbjct: 594  SADFVVEAIGDDVGTLGFSVEGPSQAKIECDDKG--DGSCDVRYWPQEAGEYAVHVLCNS 651

Query: 882  QHVASSPIPVVISQS-EIGDASRVRVSGRGLHEGHTF--EPAEFIIDTRDAGYGGLSLSI 1052
            + +  SP    I ++ +     RV+  G GL +      +PAEF +D +  G   L + +
Sbjct: 652  EDIRLSPFMADIREAPQDFHPDRVKARGPGLEKTGVAVNKPAEFTVDAKHGGKAALRVQV 711

Query: 1053 EGPS--KVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTGEGRVKE 1226
            +      VD   +D  +GT   +Y P +P  +   + +    +P SPF V V G G    
Sbjct: 712  QDNEGCPVDATVKDNGNGTYSCSYVPRKPVKHTAMVSWGGVSIPNSPFRVNV-GAGSHPN 770

Query: 1227 SITRRQRAPSVANVG--SHCDLSLKIP-------EISIQDMTAQ-VTSPSGKSHEAEIVE 1376
             +  +   P VA  G  +H      +        ++SI    A  V  P+    + +I+ 
Sbjct: 771  KV--KVYGPGVAKTGLKAHEPTYFTVDCTEAGQGDVSIGIKCAPGVVGPTEADIDFDIIR 828

Query: 1377 GENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLERA- 1553
             +N T+ +++ P   G +T+ V +  Q  P SP +  V P  +  A KV+A GPGL R  
Sbjct: 829  NDNDTFTVKYTPRGAGSYTIMVLFADQATPTSPIRVKVEPSHD--ASKVKAEGPGLSRTG 886

Query: 1554 -EAGVPAEFSIWTREAGAGGLAIAVEGPSKAE----ISFEDRKDGSCGVAYVVQEPGDYE 1718
             E G P  F+I  + AG G   +   G +K +    +   D  D +  V Y   + G   
Sbjct: 887  VELGKPTHFTINAKAAGKGKPDVQFSGLAKGDAVRDVDIIDHHDNTYTVKYTPVQQGPVG 946

Query: 1719 VSVKFNEEHIPDSPFVVPVASPSGDARRLTVSSLQESGLKVNQPASFAVSLNGA--KGAI 1892
            ++V +  + IP SPF V V SPS D  ++ VS L E  + V +   F V   GA  +G +
Sbjct: 947  INVTYGGDPIPKSPFSVGV-SPSLDLSKIKVSGLGEK-VDVGKDQEFTVKSKGAGGQGKV 1004

Query: 1893 DAKVHSPSGALEECYVTE-IDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEP 2069
             +K+  PSG    C V   +  D   VRF+PRE G Y ++V ++G  +PGSPF +    P
Sbjct: 1005 ASKITGPSGTAVPCKVEPGLGADNSVVRFVPREEGPYEVEVTYDGVPVPGSPFPVEALPP 1064

Query: 2070 GHGGDPGLVSAYGAGLEGGVTGSPAEFIVNTSNAGAGALSVTIDGPSKVKMDCQECPEGY 2249
                 P  V A+G GL+GG  GSPA F ++T  AG G L +T++GP + +++C +  +G 
Sbjct: 1065 TK---PSKVKAFGPGLQGGSAGSPARFTIDTKGAGMGGLGLTVEGPCEAQLECLDNGDGT 1121

Query: 2250 -RVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSVFVDSLTKTX 2426
              V+Y P  PG Y I+I +    HI GSPFKA V                          
Sbjct: 1122 CSVSYVPTEPGDYNINILFADT-HIPGSPFKAHVV------------------------- 1155

Query: 2427 XXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKAGNNMLLVGVHGPRTPCE 2606
                           SKV   G GL +A  G+ G F VDCS AG+  L + +        
Sbjct: 1156 ----------PCFDASKVKCSGPGLERATAGEAGQFHVDCSSAGSAELTIEIRSEAGLPA 1205

Query: 2607 EILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLV 2738
            E+ ++  G   ++++Y+    G YT+ +K+G + +P  P ++ V
Sbjct: 1206 EVHIQDHGDGTHTITYIPLCPGAYTVTIKYGGQPVPNFPSKLQV 1249



 Score =  319 bits (817), Expect = 1e-86
 Identities = 231/760 (30%), Positives = 360/760 (47%), Gaps = 43/760 (5%)
 Frame = +3

Query: 189  FTIK------KGEITGEVRMPSG-----KVAQPAITDNKDGTVTVRYAPSEAGLHEMDIR 335
            FT+K      +G++  ++  PSG     KV      DN      VR+ P E G +E+++ 
Sbjct: 991  FTVKSKGAGGQGKVASKITGPSGTAVPCKVEPGLGADNS----VVRFVPREEGPYEVEVT 1046

Query: 336  YDNMHIPGSPLQFY-VDYVNCGHVTAYGPGLSHGVVNKPAVFTVNTKDAGEGGLSLAIEG 512
            YD + +PGSP     +       V A+GPGL  G    PA FT++TK AG GGL L +EG
Sbjct: 1047 YDGVPVPGSPFPVEALPPTKPSKVKAFGPGLQGGSAGSPARFTIDTKGAGMGGLGLTVEG 1106

Query: 513  PSKAEISCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARVTG--DDSM---- 674
            P +A++ C DN DGTCSVSY+P  PGDY+I + + + HIPGSPF A V    D S     
Sbjct: 1107 PCEAQLECLDNGDGTCSVSYVPTEPGDYNINILFADTHIPGSPFKAHVVPCFDASKVKCS 1166

Query: 675  --RMSHLKVGSAADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKET 848
               +     G A    ++ S    + LT  +   +G      ++   +G   I+++P   
Sbjct: 1167 GPGLERATAGEAGQFHVDCSSAGSAELTIEIRSEAGLPAEVHIQDHGDGTHTITYIPLCP 1226

Query: 849  GEHLVHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEGHTFEPA--EFIIDTR- 1019
            G + V +K  GQ V + P  + +  +   D S V+  G G+     F  A  EF +D R 
Sbjct: 1227 GAYTVTIKYGGQPVPNFPSKLQVEPAV--DTSGVQCYGPGIEGQGVFREATTEFSVDARA 1284

Query: 1020 --DAGYGGLSLSIEGPS--KVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSP 1187
                G   +   +  PS    +   +D  DGT +V Y P E G + +++ +    VP SP
Sbjct: 1285 LTQTGGPHVKARVANPSGNLTETYVQDCGDGTYKVEYTPYEEGLHSVDVTYDGSPVPSSP 1344

Query: 1188 FSVKVTGEGRVKESITRRQRAPSVANVGSHCDLSLKIPEISIQDMTAQVTSPSGKSHEAE 1367
            F V VT EG     +                  +++        +   V  PS    +  
Sbjct: 1345 FQVPVT-EGCDPSRVRVHGPGIQSGTTNKPNKFTVETRGAGTGGLGLAVEGPS--EAKMS 1401

Query: 1368 IVEGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLE 1547
             ++ ++ +  + ++P E G ++++V Y G  VPGSPF+  V  + +  A KV+  GPGL 
Sbjct: 1402 CMDNKDGSCSVEYIPYEAGTYSLNVTYGGHQVPGSPFKVPVHDVTD--ASKVKCSGPGLS 1459

Query: 1548 --RAEAGVPAEFSIWTREAGAGGLAIAVEGPS--KAEISFEDRKDGSCGVAYVVQEPGDY 1715
                 A +P  F + T +AG   L + V+GP      +   D  DG+  V YV    G Y
Sbjct: 1460 PGMVRANLPQSFQVDTSKAGVAPLQVKVQGPKGLVEPVDVVDNADGTQTVNYVPSREGPY 1519

Query: 1716 EVSVKFNEEHIPDSPFVVPVASPSGDARRLTVS--SLQESGLKVNQPASFAVSLNGA-KG 1886
             +SV + EE +P SPF V V  P+ DA ++  S   L  +G+  + P  F +    A +G
Sbjct: 1520 SISVLYGEEEVPRSPFKVKVL-PTHDASKVKASGPGLNTTGVPASLPVEFTIDAKDAGEG 1578

Query: 1887 AIDAKVHSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGE 2066
             +  ++  P G  ++ ++ +     Y V ++P   G Y I +K+ G  IP SP+++R   
Sbjct: 1579 LLAVQITDPEGKPKKTHIQDNHDGTYTVAYVPDVTGRYTILIKYGGDEIPFSPYRVRAVP 1638

Query: 2067 PGHGGDPGL-VSAYGAGLEGGV-----TGSPAEFIVNTSNAGAGALSVTIDGP--SKVKM 2222
             G      + VS  G GL  G+      G      V+T  AG G ++ T+  P  S+V +
Sbjct: 1639 TGDASKCTVTVSIGGHGLGAGIGPTIQIGEETVITVDTKAAGKGKVTCTVCTPDGSEVDV 1698

Query: 2223 DCQECPEG-YRVTYTPMAPGSYLISIKYGGPYHIGGSPFK 2339
            D  E  +G + + YT   PG Y+I +++GG  H+  SPF+
Sbjct: 1699 DVVENEDGTFDIFYTAPQPGKYVICVRFGGE-HVPNSPFQ 1737



 Score =  286 bits (733), Expect = 6e-77
 Identities = 248/893 (27%), Positives = 386/893 (43%), Gaps = 47/893 (5%)
 Frame = +3

Query: 201  KGEITGEVRMPSGKVAQPAITDNKDG--TVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQF 374
            +GE+   V  P+G   +  +T N D   T +V Y P   G H++ + +   HI  SP + 
Sbjct: 313  QGEVLVYVEDPAGHQEEAKVTANNDKNRTFSVWYVPEVTGTHKVTVLFAGQHIAKSPFEV 372

Query: 375  YVD--YVNCGHVTAYGPGL--SHGVVNKPAVFTVNTKDAGEGGLSLAIEGPS----KAEI 530
            YVD    +   VTA GPGL  S  + NK   F + T  AG G + + I+ P+      E 
Sbjct: 373  YVDKSQGDASKVTAQGPGLEPSGNIANKTTYFEIFTAGAGTGEVEVVIQDPTGQKGTVEP 432

Query: 531  SCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARV----------TGDDSMRM 680
                  D T   SY P + G +++ V +    IP SP+T  V               ++ 
Sbjct: 433  QLEARGDSTYRCSYQPTMEGVHTVHVTFAGVPIPRSPYTVTVGQACNPGACRAVGRGLQP 492

Query: 681  SHLKVGSAADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHL 860
              ++V   AD  +         L  TV  P G EE    K L +G  G  + P   G + 
Sbjct: 493  KGVRVKETADFKVYTKGAGSGDLKVTVKGPKG-EERVKQKDLGDGVYGFEYYPMVPGTYT 551

Query: 861  VHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEGHTFEPAEFIIDTRDAGYGGL 1040
            V +   GQ++  SP  V +  +E G+  +VR  G GL  G   + A+F+++      G L
Sbjct: 552  VTITWGGQNIGRSPFEVKVG-TECGN-QKVRAWGPGLEGGVVGKSADFVVEAIGDDVGTL 609

Query: 1041 SLSIEGPSKVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTGEGRV 1220
              S+EGPS+  I  +D  DG+C V Y P E G Y +++    + +  SPF   +    + 
Sbjct: 610  GFSVEGPSQAKIECDDKGDGSCDVRYWPQEAGEYAVHVLCNSEDIRLSPFMADIREAPQD 669

Query: 1221 KESITRRQRAPSVANVG----SHCDLSLKIPEISIQDMTAQVTSPSGKSHEAEIVEGENH 1388
                  + R P +   G       + ++         +  QV    G   +A + +  N 
Sbjct: 670  FHPDRVKARGPGLEKTGVAVNKPAEFTVDAKHGGKAALRVQVQDNEGCPVDATVKDNGNG 729

Query: 1389 TYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAH--KVRAGGPGLERA--E 1556
            TY   +VP +   HT  V + G  +P SPF+  VG     G+H  KV+  GPG+ +   +
Sbjct: 730  TYSCSYVPRKPVKHTAMVSWGGVSIPNSPFRVNVG----AGSHPNKVKVYGPGVAKTGLK 785

Query: 1557 AGVPAEFSIWTREAGAGGLAIAVE------GPSKAEISFE--DRKDGSCGVAYVVQEPGD 1712
            A  P  F++   EAG G ++I ++      GP++A+I F+     + +  V Y  +  G 
Sbjct: 786  AHEPTYFTVDCTEAGQGDVSIGIKCAPGVVGPTEADIDFDIIRNDNDTFTVKYTPRGAGS 845

Query: 1713 YEVSVKFNEEHIPDSPFVVPVASPSGDARRLTVS--SLQESGLKVNQPASFAVSLNGA-K 1883
            Y + V F ++  P SP  V V  PS DA ++      L  +G+++ +P  F ++   A K
Sbjct: 846  YTIMVLFADQATPTSPIRVKV-EPSHDASKVKAEGPGLSRTGVELGKPTHFTINAKAAGK 904

Query: 1884 GAIDAKVH--SPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIR 2057
            G  D +    +   A+ +  + +   + Y V++ P + G   I+V + G  IP SPF + 
Sbjct: 905  GKPDVQFSGLAKGDAVRDVDIIDHHDNTYTVKYTPVQQGPVGINVTYGGDPIPKSPFSVG 964

Query: 2058 VGEPGHGGDPGLVSAYGAGLEGGVTGSPAEFIVNTSNAGA-GALSVTIDGPSKVKMDCQE 2234
            V       D   +   G G +  V G   EF V +  AG  G ++  I GPS   + C+ 
Sbjct: 965  VSP---SLDLSKIKVSGLGEKVDV-GKDQEFTVKSKGAGGQGKVASKITGPSGTAVPCKV 1020

Query: 2235 CP----EGYRVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSVF 2402
             P    +   V + P   G Y + + Y G   + GSPF                      
Sbjct: 1021 EPGLGADNSVVRFVPREEGPYEVEVTYDG-VPVPGSPFP--------------------- 1058

Query: 2403 VDSLTKTXXXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKAGNNMLLVGV 2582
            V++L  T                SKV A G GL     G    FT+D   AG   L + V
Sbjct: 1059 VEALPPT--------------KPSKVKAFGPGLQGGSAGSPARFTIDTKGAGMGGLGLTV 1104

Query: 2583 HGPRTPCE-EILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLV 2738
             G   PCE ++     G    SVSY+  + G+Y + + + D HIPGSP++  V
Sbjct: 1105 EG---PCEAQLECLDNGDGTCSVSYVPTEPGDYNINILFADTHIPGSPFKAHV 1154



 Score =  226 bits (577), Expect = 8e-59
 Identities = 230/843 (27%), Positives = 366/843 (43%), Gaps = 50/843 (5%)
 Frame = +3

Query: 354  PGSPLQFYVDYVNCGHVTAYGPGL--SHGVVNKPAVFTVNTKDAGEGGLSLAIEGPS--- 518
            PG+PL+     +N     AYGPG+  +  +V K A FTV T+ AG+G + + +E P+   
Sbjct: 271  PGAPLR---PKLNPKKARAYGPGIEPTGNMVKKRAEFTVETRSAGQGEVLVYVEDPAGHQ 327

Query: 519  -KAEISCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARV--TGDDSMRMSHL 689
             +A+++  ++++ T SV Y+P + G + + V +  QHI  SPF   V  +  D+ +++  
Sbjct: 328  EEAKVTANNDKNRTFSVWYVPEVTGTHKVTVLFAGQHIAKSPFEVYVDKSQGDASKVTAQ 387

Query: 690  KVGSAADIPINISETDLSLLTA---------TVVPPSGRE---EPCLLKRLRNGHVGISF 833
              G      I    T   + TA          +  P+G++   EP L  R  +     S+
Sbjct: 388  GPGLEPSGNIANKTTYFEIFTAGAGTGEVEVVIQDPTGQKGTVEPQLEAR-GDSTYRCSY 446

Query: 834  VPKETGEHLVHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEG--HTFEPAEFI 1007
             P   G H VHV   G  +  SP  V + Q+   +    R  GRGL        E A+F 
Sbjct: 447  QPTMEGVHTVHVTFAGVPIPRSPYTVTVGQA--CNPGACRAVGRGLQPKGVRVKETADFK 504

Query: 1008 IDTRDAGYGGLSLSIEGPSKVD-INTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGS 1184
            + T+ AG G L ++++GP   + +  +DL DG     Y P  PG Y + I +  Q++  S
Sbjct: 505  VYTKGAGSGDLKVTVKGPKGEERVKQKDLGDGVYGFEYYPMVPGTYTVTITWGGQNIGRS 564

Query: 1185 PFSVKVTGE-GRVKESITRRQRAPSVAN--VGSHCDLSLKIPEISIQDMTAQVTSPSGKS 1355
            PF VKV  E G  K     R   P +    VG   D  ++     +  +   V  PS   
Sbjct: 565  PFEVKVGTECGNQKV----RAWGPGLEGGVVGKSADFVVEAIGDDVGTLGFSVEGPSQAK 620

Query: 1356 HEAEIVEGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEG-GAHKVRAG 1532
             E +  +  + +  +R+ P E G + V V    + +  SPF   +    +     +V+A 
Sbjct: 621  IECD--DKGDGSCDVRYWPQEAGEYAVHVLCNSEDIRLSPFMADIREAPQDFHPDRVKAR 678

Query: 1533 GPGLERAEAGV--PAEFSIWTREAGAGGLAIAVEGPS--KAEISFEDRKDGSCGVAYVVQ 1700
            GPGLE+    V  PAEF++  +  G   L + V+       + + +D  +G+   +YV +
Sbjct: 679  GPGLEKTGVAVNKPAEFTVDAKHGGKAALRVQVQDNEGCPVDATVKDNGNGTYSCSYVPR 738

Query: 1701 EPGDYEVSVKFNEEHIPDSPFVVPVASPSGDAR-RLTVSSLQESGLKVNQPASFAVSLNG 1877
            +P  +   V +    IP+SPF V V + S   + ++    + ++GLK ++P  F V    
Sbjct: 739  KPVKHTAMVSWGGVSIPNSPFRVNVGAGSHPNKVKVYGPGVAKTGLKAHEPTYFTVDCTE 798

Query: 1878 A-KGAIDAKVH------SPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIP 2036
            A +G +   +        P+ A  +  +   D D + V++ PR  G Y I V F     P
Sbjct: 799  AGQGDVSIGIKCAPGVVGPTEADIDFDIIRNDNDTFTVKYTPRGAGSYTIMVLFADQATP 858

Query: 2037 GSPFKIRVGEPGHGGDPGLVSAYGAGLE--GGVTGSPAEFIVNTSNAGAGALSVTIDGPS 2210
             SP +++V EP H  D   V A G GL   G   G P  F +N   AG G   V   G +
Sbjct: 859  TSPIRVKV-EPSH--DASKVKAEGPGLSRTGVELGKPTHFTINAKAAGKGKPDVQFSGLA 915

Query: 2211 K----VKMDCQECPEG-YRVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNH 2375
            K      +D  +  +  Y V YTP+  G   I++ YGG   I  SPF   V+        
Sbjct: 916  KGDAVRDVDIIDHHDNTYTVKYTPVQQGPVGINVTYGGD-PIPKSPFSVGVS-------- 966

Query: 2376 SLHETSSVFVDSLTKTXXXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKA 2555
                                            SK+   GLG  K  VG+   FTV    A
Sbjct: 967  ---------------------------PSLDLSKIKVSGLG-EKVDVGKDQEFTVKSKGA 998

Query: 2556 GNN----MLLVGVHGPRTPCEEILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSP 2723
            G        + G  G   PC+  +   +G+    V ++ +++G Y + V +    +PGSP
Sbjct: 999  GGQGKVASKITGPSGTAVPCK--VEPGLGADNSVVRFVPREEGPYEVEVTYDGVPVPGSP 1056

Query: 2724 YRV 2732
            + V
Sbjct: 1057 FPV 1059


>ref|XP_867527.1| PREDICTED: similar to Filamin A (Alpha-filamin) (Filamin 1)
            (Endothelial actin-binding protein) (Actin-binding
            protein 280) (ABP-280) (Nonmuscle filamin) isoform 7
            [Canis familiaris].
          Length = 2642

 Score = 1746 bits (4522), Expect = 0.0
 Identities = 867/913 (94%), Positives = 878/913 (96%)
 Frame = +3

Query: 3    PFQVTALAGEQPSVXXXXXXXXXXXXYTYAQGGQQTWAPERPLVGVNGLDVTSLRPFDLV 182
            PFQVTALAG+QP+             YTYAQGGQQTWAPERPL+GVNGLDVTSLRPFDLV
Sbjct: 1735 PFQVTALAGDQPAAQPPLRPQQLAPPYTYAQGGQQTWAPERPLMGVNGLDVTSLRPFDLV 1794

Query: 183  IPFTIKKGEITGEVRMPSGKVAQPAITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGS 362
            IPFTIKKGEITGEVRMPSGKVAQPAITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGS
Sbjct: 1795 IPFTIKKGEITGEVRMPSGKVAQPAITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGS 1854

Query: 363  PLQFYVDYVNCGHVTAYGPGLSHGVVNKPAVFTVNTKDAGEGGLSLAIEGPSKAEISCTD 542
            PLQFYVDYVNCGHVTAYGPGL+HGVVNKPAVFTVNTKDAGEGGLSLAIEGPSKAEISCTD
Sbjct: 1855 PLQFYVDYVNCGHVTAYGPGLTHGVVNKPAVFTVNTKDAGEGGLSLAIEGPSKAEISCTD 1914

Query: 543  NQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARVTGDDSMRMSHLKVGSAADIPIN 722
            NQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARVTGDDSMRMSHLKVGSAADIPIN
Sbjct: 1915 NQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARVTGDDSMRMSHLKVGSAADIPIN 1974

Query: 723  ISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNGQHVASSP 902
            ISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNGQHVASSP
Sbjct: 1975 ISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNGQHVASSP 2034

Query: 903  IPVVISQSEIGDASRVRVSGRGLHEGHTFEPAEFIIDTRDAGYGGLSLSIEGPSKVDINT 1082
            IPVVISQSEIGDASRVRVSG+GLHEGHTFEPAEFIIDTRDAGYGGLSLSIEGPSKVDINT
Sbjct: 2035 IPVVISQSEIGDASRVRVSGQGLHEGHTFEPAEFIIDTRDAGYGGLSLSIEGPSKVDINT 2094

Query: 1083 EDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTGEGRVKESITRRQRAPSVA 1262
            EDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTGEGRVKESITRR+RAPSVA
Sbjct: 2095 EDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTGEGRVKESITRRRRAPSVA 2154

Query: 1263 NVGSHCDLSLKIPEISIQDMTAQVTSPSGKSHEAEIVEGENHTYCIRFVPAEMGMHTVSV 1442
            NVGSHC+LSLKIPEISIQDMTAQVTSPSGK+HEAEIVEGENHTYCIRFVPAEMGMHTVSV
Sbjct: 2155 NVGSHCNLSLKIPEISIQDMTAQVTSPSGKTHEAEIVEGENHTYCIRFVPAEMGMHTVSV 2214

Query: 1443 KYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLERAEAGVPAEFSIWTREAGAGGLAIA 1622
            KYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLERAEAGVPAEFSIWTREAGAGGLAIA
Sbjct: 2215 KYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLERAEAGVPAEFSIWTREAGAGGLAIA 2274

Query: 1623 VEGPSKAEISFEDRKDGSCGVAYVVQEPGDYEVSVKFNEEHIPDSPFVVPVASPSGDARR 1802
            VEGPSKAEISFEDRKDGSCGVAYVVQEPGDYEVSVKFNEEHIPDSPFVVPVASPSGDARR
Sbjct: 2275 VEGPSKAEISFEDRKDGSCGVAYVVQEPGDYEVSVKFNEEHIPDSPFVVPVASPSGDARR 2334

Query: 1803 LTVSSLQESGLKVNQPASFAVSLNGAKGAIDAKVHSPSGALEECYVTEIDQDKYAVRFIP 1982
            LTVSSLQESGLKVNQPASFAVSLNGAKGAIDAKVHSPSGALEECYVTEIDQDKYAVRFIP
Sbjct: 2335 LTVSSLQESGLKVNQPASFAVSLNGAKGAIDAKVHSPSGALEECYVTEIDQDKYAVRFIP 2394

Query: 1983 RENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPGLVSAYGAGLEGGVTGSPAEFIVNT 2162
            RENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPGLVSAYGAGLEGGVTGSPAEFIVNT
Sbjct: 2395 RENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPGLVSAYGAGLEGGVTGSPAEFIVNT 2454

Query: 2163 SNAGAGALSVTIDGPSKVKMDCQECPEGYRVTYTPMAPGSYLISIKYGGPYHIGGSPFKA 2342
            SNAGAGALSVTIDGPSKVKMDCQECPEGYRVTYTPMAPGSYLISIKYGGPYHIGGSPFKA
Sbjct: 2455 SNAGAGALSVTIDGPSKVKMDCQECPEGYRVTYTPMAPGSYLISIKYGGPYHIGGSPFKA 2514

Query: 2343 RVTGHRLVSNHSLHETSSVFVDSLTKTXXXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQ 2522
            +VTG     NHSLHETSSVFVDSLTKT                SKVLAKGLGLSKAYVGQ
Sbjct: 2515 KVTG----DNHSLHETSSVFVDSLTKT-ASAPQHGALAGSTDASKVLAKGLGLSKAYVGQ 2569

Query: 2523 KGSFTVDCSKAGNNMLLVGVHGPRTPCEEILVKHVGSRLYSVSYLLKDKGEYTLVVKWGD 2702
            K SFTVDCSKAGNNMLLVGVHGPRTPCEEILVKHVG+RLY+VSYLLKDKGEYTLVVKWGD
Sbjct: 2570 KSSFTVDCSKAGNNMLLVGVHGPRTPCEEILVKHVGNRLYNVSYLLKDKGEYTLVVKWGD 2629

Query: 2703 EHIPGSPYRVLVP 2741
            EHIPGSPYRVLVP
Sbjct: 2630 EHIPGSPYRVLVP 2642



 Score =  425 bits (1092), Expect = e-118
 Identities = 282/883 (31%), Positives = 436/883 (49%), Gaps = 52/883 (5%)
 Frame = +3

Query: 246  AQPAITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFYV-DYVNCGHVTAYGPG 422
            A+ +  DNKDG+ +V Y P EAG + +++ Y    +PGSP +  V D  +   V   GPG
Sbjct: 1398 AKMSCMDNKDGSCSVEYIPYEAGTYSLNVTYGGHQVPGSPFKVPVHDVTDASKVKCSGPG 1457

Query: 423  LSHGVV--NKPAVFTVNTKDAGEGGLSLAIEGPSKA--EISCTDNQDGTCSVSYLPVLPG 590
            LS G+V  N P  F V+T  AG   L + ++GP      +   DN DGT +V+Y+P   G
Sbjct: 1458 LSPGMVRANLPQSFQVDTSKAGVAPLQVKVQGPKGLVEPVDVVDNADGTQTVNYVPSREG 1517

Query: 591  DYSILVKYNEQHIPGSPFTARV--TGDDS--------MRMSHLKVGSAADIPINISETDL 740
             YSI V Y E+ +P SPF  +V  T D S        +  + +      +  I+  +   
Sbjct: 1518 PYSISVLYGEEEVPRSPFKVKVLPTHDASKVKASGPGLNTTGVPASLPVEFTIDAKDAGE 1577

Query: 741  SLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNGQHVASSPIPVVIS 920
             LL   +  P G+ +   ++   +G   +++VP  TG + + +K  G  +  SP  V   
Sbjct: 1578 GLLAVQITDPEGKPKKTHIQDNHDGTYTVAYVPDVTGRYTILIKYGGDEIPFSPYRVRAV 1637

Query: 921  QSEIGDASR----VRVSGRGLHEG-----HTFEPAEFIIDTRDAGYGGLSLSIEGP--SK 1067
             +  GDAS+    V + G GL  G        E     +DT+ AG G ++ ++  P  S+
Sbjct: 1638 PT--GDASKCTVTVSIGGHGLGAGIGPTIQIGEETVITVDTKAAGKGKVTCTVCTPDGSE 1695

Query: 1068 VDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTG--EGRVKESITRR 1241
            VD++  + EDGT  + Y   +PG Y+I ++F  +HVP SPF V      +   +  +  +
Sbjct: 1696 VDVDVVENEDGTFDIFYTAPQPGKYVICVRFGGEHVPNSPFQVTALAGDQPAAQPPLRPQ 1755

Query: 1242 QRAPSVA---------------------NVGSHCDLSLKIP-EISIQDMTAQVTSPSGKS 1355
            Q AP                        +V S     L IP  I   ++T +V  PSGK 
Sbjct: 1756 QLAPPYTYAQGGQQTWAPERPLMGVNGLDVTSLRPFDLVIPFTIKKGEITGEVRMPSGKV 1815

Query: 1356 HEAEIVEGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGG 1535
             +  I + ++ T  +R+ P+E G+H + ++Y   H+PGSP QF V  +  G    V A G
Sbjct: 1816 AQPAITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFYVDYVNCG---HVTAYG 1872

Query: 1536 PGLERAEAGVPAEFSIWTREAGAGGLAIAVEGPSKAEISFEDRKDGSCGVAYVVQEPGDY 1715
            PGL       PA F++ T++AG GGL++A+EGPSKAEIS  D +DG+C V+Y+   PGDY
Sbjct: 1873 PGLTHGVVNKPAVFTVNTKDAGEGGLSLAIEGPSKAEISCTDNQDGTCSVSYLPVLPGDY 1932

Query: 1716 EVSVKFNEEHIPDSPFVVPVASPSGDARRLTVSSLQESGLKVNQPASFAVSLNGAK-GAI 1892
             + VK+NE+HIP SPF   V   +GD       S++ S LKV   A   ++++      +
Sbjct: 1933 SILVKYNEQHIPGSPFTARV---TGD------DSMRMSHLKVGSAADIPINISETDLSLL 1983

Query: 1893 DAKVHSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPG 2072
             A V  PSG  E C +  +      + F+P+E G +L+ VK NG H+  SP  + + +  
Sbjct: 1984 TATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNGQHVASSPIPVVISQ-S 2042

Query: 2073 HGGDPGLVSAYGAGLEGGVTGSPAEFIVNTSNAGAGALSVTIDGPSKVKMDCQECPEG-Y 2249
              GD   V   G GL  G T  PAEFI++T +AG G LS++I+GPSKV ++ ++  +G  
Sbjct: 2043 EIGDASRVRVSGQGLHEGHTFEPAEFIIDTRDAGYGGLSLSIEGPSKVDINTEDLEDGTC 2102

Query: 2250 RVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSVFVDSLTKTXX 2429
            RVTY P  PG+Y+I+IK+    H+ GSPF  +VTG   V             +S+T+   
Sbjct: 2103 RVTYCPTEPGNYIINIKF-ADQHVPGSPFSVKVTGEGRVK------------ESITR--- 2146

Query: 2430 XXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKAGNNMLLVGVHGPRTPCEE 2609
                               +    S A VG   + ++   +     +   V  P     E
Sbjct: 2147 -------------------RRRAPSVANVGSHCNLSLKIPEISIQDMTAQVTSPSGKTHE 2187

Query: 2610 ILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLV 2738
              +    +  Y + ++  + G +T+ VK+  +H+PGSP++  V
Sbjct: 2188 AEIVEGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTV 2230



 Score =  347 bits (891), Expect = 3e-95
 Identities = 264/884 (29%), Positives = 409/884 (46%), Gaps = 39/884 (4%)
 Frame = +3

Query: 204  GEITGEVRMPSGK--VAQPAITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFY 377
            GE+   ++ P+G+    +P +    D T    Y P+  G+H + + +  + IP SP    
Sbjct: 414  GEVEVVIQDPTGQKGTVEPQLEARGDSTYRCSYQPTMEGVHTVHVTFAGVPIPRSPYTVT 473

Query: 378  VDYV-NCGHVTAYGPGLS-HGV-VNKPAVFTVNTKDAGEGGLSLAIEGPSKAE-ISCTDN 545
            V    N G   A G GL   GV V + A F V TK AG G L + ++GP   E +   D 
Sbjct: 474  VGQACNPGACRAVGRGLQPKGVRVKETADFKVYTKGAGSGDLKVTVKGPKGEERVKQKDL 533

Query: 546  QDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARV---TGDDSMR-----MSHLKVGS 701
             DG     Y P++PG Y++ + +  Q+I  SPF  +V    G+  +R     +    VG 
Sbjct: 534  GDGVYGFEYYPMVPGTYTVTITWGGQNIGRSPFEVKVGTECGNQKVRAWGPGLEGGVVGK 593

Query: 702  AADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNG 881
            +AD  +     D+  L  +V  PS  +  C  K   +G   + + P+E GE+ VHV  N 
Sbjct: 594  SADFVVEAIGDDVGTLGFSVEGPSQAKIECDDKG--DGSCDVRYWPQEAGEYAVHVLCNS 651

Query: 882  QHVASSPIPVVISQS-EIGDASRVRVSGRGLHEGHTF--EPAEFIIDTRDAGYGGLSLSI 1052
            + +  SP    I ++ +     RV+  G GL +      +PAEF +D +  G   L + +
Sbjct: 652  EDIRLSPFMADIREAPQDFHPDRVKARGPGLEKTGVAVNKPAEFTVDAKHGGKAALRVQV 711

Query: 1053 EGPS--KVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTGEGRVKE 1226
            +      VD   +D  +GT   +Y P +P  +   + +    +P SPF V V G G    
Sbjct: 712  QDNEGCPVDATVKDNGNGTYSCSYVPRKPVKHTAMVSWGGVSIPNSPFRVNV-GAGSHPN 770

Query: 1227 SITRRQRAPSVANVG--SHCDLSLKIP-------EISIQDMTAQ-VTSPSGKSHEAEIVE 1376
             +  +   P VA  G  +H      +        ++SI    A  V  P+    + +I+ 
Sbjct: 771  KV--KVYGPGVAKTGLKAHEPTYFTVDCTEAGQGDVSIGIKCAPGVVGPTEADIDFDIIR 828

Query: 1377 GENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLERA- 1553
             +N T+ +++ P   G +T+ V +  Q  P SP +  V P  +  A KV+A GPGL R  
Sbjct: 829  NDNDTFTVKYTPRGAGSYTIMVLFADQATPTSPIRVKVEPSHD--ASKVKAEGPGLSRTG 886

Query: 1554 -EAGVPAEFSIWTREAGAGGLAIAVEGPSKAE----ISFEDRKDGSCGVAYVVQEPGDYE 1718
             E G P  F+I  + AG G   +   G +K +    +   D  D +  V Y   + G   
Sbjct: 887  VELGKPTHFTINAKAAGKGKPDVQFSGLAKGDAVRDVDIIDHHDNTYTVKYTPVQQGPVG 946

Query: 1719 VSVKFNEEHIPDSPFVVPVASPSGDARRLTVSSLQESGLKVNQPASFAVSLNGA--KGAI 1892
            ++V +  + IP SPF V V SPS D  ++ VS L E  + V +   F V   GA  +G +
Sbjct: 947  INVTYGGDPIPKSPFSVGV-SPSLDLSKIKVSGLGEK-VDVGKDQEFTVKSKGAGGQGKV 1004

Query: 1893 DAKVHSPSGALEECYVTE-IDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEP 2069
             +K+  PSG    C V   +  D   VRF+PRE G Y ++V ++G  +PGSPF +    P
Sbjct: 1005 ASKITGPSGTAVPCKVEPGLGADNSVVRFVPREEGPYEVEVTYDGVPVPGSPFPVEALPP 1064

Query: 2070 GHGGDPGLVSAYGAGLEGGVTGSPAEFIVNTSNAGAGALSVTIDGPSKVKMDCQECPEGY 2249
                 P  V A+G GL+GG  GSPA F ++T  AG G L +T++GP + +++C +  +G 
Sbjct: 1065 TK---PSKVKAFGPGLQGGSAGSPARFTIDTKGAGMGGLGLTVEGPCEAQLECLDNGDGT 1121

Query: 2250 -RVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSVFVDSLTKTX 2426
              V+Y P  PG Y I+I +    HI GSPFKA V                          
Sbjct: 1122 CSVSYVPTEPGDYNINILFADT-HIPGSPFKAHVV------------------------- 1155

Query: 2427 XXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKAGNNMLLVGVHGPRTPCE 2606
                           SKV   G GL +A  G+ G F VDCS AG+  L + +        
Sbjct: 1156 ----------PCFDASKVKCSGPGLERATAGEAGQFHVDCSSAGSAELTIEIRSEAGLPA 1205

Query: 2607 EILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLV 2738
            E+ ++  G   ++++Y+    G YT+ +K+G + +P  P ++ V
Sbjct: 1206 EVHIQDHGDGTHTITYIPLCPGAYTVTIKYGGQPVPNFPSKLQV 1249



 Score =  319 bits (817), Expect = 1e-86
 Identities = 231/760 (30%), Positives = 360/760 (47%), Gaps = 43/760 (5%)
 Frame = +3

Query: 189  FTIK------KGEITGEVRMPSG-----KVAQPAITDNKDGTVTVRYAPSEAGLHEMDIR 335
            FT+K      +G++  ++  PSG     KV      DN      VR+ P E G +E+++ 
Sbjct: 991  FTVKSKGAGGQGKVASKITGPSGTAVPCKVEPGLGADNS----VVRFVPREEGPYEVEVT 1046

Query: 336  YDNMHIPGSPLQFY-VDYVNCGHVTAYGPGLSHGVVNKPAVFTVNTKDAGEGGLSLAIEG 512
            YD + +PGSP     +       V A+GPGL  G    PA FT++TK AG GGL L +EG
Sbjct: 1047 YDGVPVPGSPFPVEALPPTKPSKVKAFGPGLQGGSAGSPARFTIDTKGAGMGGLGLTVEG 1106

Query: 513  PSKAEISCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARVTG--DDSM---- 674
            P +A++ C DN DGTCSVSY+P  PGDY+I + + + HIPGSPF A V    D S     
Sbjct: 1107 PCEAQLECLDNGDGTCSVSYVPTEPGDYNINILFADTHIPGSPFKAHVVPCFDASKVKCS 1166

Query: 675  --RMSHLKVGSAADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKET 848
               +     G A    ++ S    + LT  +   +G      ++   +G   I+++P   
Sbjct: 1167 GPGLERATAGEAGQFHVDCSSAGSAELTIEIRSEAGLPAEVHIQDHGDGTHTITYIPLCP 1226

Query: 849  GEHLVHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEGHTFEPA--EFIIDTR- 1019
            G + V +K  GQ V + P  + +  +   D S V+  G G+     F  A  EF +D R 
Sbjct: 1227 GAYTVTIKYGGQPVPNFPSKLQVEPAV--DTSGVQCYGPGIEGQGVFREATTEFSVDARA 1284

Query: 1020 --DAGYGGLSLSIEGPS--KVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSP 1187
                G   +   +  PS    +   +D  DGT +V Y P E G + +++ +    VP SP
Sbjct: 1285 LTQTGGPHVKARVANPSGNLTETYVQDCGDGTYKVEYTPYEEGLHSVDVTYDGSPVPSSP 1344

Query: 1188 FSVKVTGEGRVKESITRRQRAPSVANVGSHCDLSLKIPEISIQDMTAQVTSPSGKSHEAE 1367
            F V VT EG     +                  +++        +   V  PS    +  
Sbjct: 1345 FQVPVT-EGCDPSRVRVHGPGIQSGTTNKPNKFTVETRGAGTGGLGLAVEGPS--EAKMS 1401

Query: 1368 IVEGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLE 1547
             ++ ++ +  + ++P E G ++++V Y G  VPGSPF+  V  + +  A KV+  GPGL 
Sbjct: 1402 CMDNKDGSCSVEYIPYEAGTYSLNVTYGGHQVPGSPFKVPVHDVTD--ASKVKCSGPGLS 1459

Query: 1548 --RAEAGVPAEFSIWTREAGAGGLAIAVEGPS--KAEISFEDRKDGSCGVAYVVQEPGDY 1715
                 A +P  F + T +AG   L + V+GP      +   D  DG+  V YV    G Y
Sbjct: 1460 PGMVRANLPQSFQVDTSKAGVAPLQVKVQGPKGLVEPVDVVDNADGTQTVNYVPSREGPY 1519

Query: 1716 EVSVKFNEEHIPDSPFVVPVASPSGDARRLTVS--SLQESGLKVNQPASFAVSLNGA-KG 1886
             +SV + EE +P SPF V V  P+ DA ++  S   L  +G+  + P  F +    A +G
Sbjct: 1520 SISVLYGEEEVPRSPFKVKVL-PTHDASKVKASGPGLNTTGVPASLPVEFTIDAKDAGEG 1578

Query: 1887 AIDAKVHSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGE 2066
             +  ++  P G  ++ ++ +     Y V ++P   G Y I +K+ G  IP SP+++R   
Sbjct: 1579 LLAVQITDPEGKPKKTHIQDNHDGTYTVAYVPDVTGRYTILIKYGGDEIPFSPYRVRAVP 1638

Query: 2067 PGHGGDPGL-VSAYGAGLEGGV-----TGSPAEFIVNTSNAGAGALSVTIDGP--SKVKM 2222
             G      + VS  G GL  G+      G      V+T  AG G ++ T+  P  S+V +
Sbjct: 1639 TGDASKCTVTVSIGGHGLGAGIGPTIQIGEETVITVDTKAAGKGKVTCTVCTPDGSEVDV 1698

Query: 2223 DCQECPEG-YRVTYTPMAPGSYLISIKYGGPYHIGGSPFK 2339
            D  E  +G + + YT   PG Y+I +++GG  H+  SPF+
Sbjct: 1699 DVVENEDGTFDIFYTAPQPGKYVICVRFGGE-HVPNSPFQ 1737



 Score =  286 bits (733), Expect = 6e-77
 Identities = 248/893 (27%), Positives = 386/893 (43%), Gaps = 47/893 (5%)
 Frame = +3

Query: 201  KGEITGEVRMPSGKVAQPAITDNKDG--TVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQF 374
            +GE+   V  P+G   +  +T N D   T +V Y P   G H++ + +   HI  SP + 
Sbjct: 313  QGEVLVYVEDPAGHQEEAKVTANNDKNRTFSVWYVPEVTGTHKVTVLFAGQHIAKSPFEV 372

Query: 375  YVD--YVNCGHVTAYGPGL--SHGVVNKPAVFTVNTKDAGEGGLSLAIEGPS----KAEI 530
            YVD    +   VTA GPGL  S  + NK   F + T  AG G + + I+ P+      E 
Sbjct: 373  YVDKSQGDASKVTAQGPGLEPSGNIANKTTYFEIFTAGAGTGEVEVVIQDPTGQKGTVEP 432

Query: 531  SCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARV----------TGDDSMRM 680
                  D T   SY P + G +++ V +    IP SP+T  V               ++ 
Sbjct: 433  QLEARGDSTYRCSYQPTMEGVHTVHVTFAGVPIPRSPYTVTVGQACNPGACRAVGRGLQP 492

Query: 681  SHLKVGSAADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHL 860
              ++V   AD  +         L  TV  P G EE    K L +G  G  + P   G + 
Sbjct: 493  KGVRVKETADFKVYTKGAGSGDLKVTVKGPKG-EERVKQKDLGDGVYGFEYYPMVPGTYT 551

Query: 861  VHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEGHTFEPAEFIIDTRDAGYGGL 1040
            V +   GQ++  SP  V +  +E G+  +VR  G GL  G   + A+F+++      G L
Sbjct: 552  VTITWGGQNIGRSPFEVKVG-TECGN-QKVRAWGPGLEGGVVGKSADFVVEAIGDDVGTL 609

Query: 1041 SLSIEGPSKVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTGEGRV 1220
              S+EGPS+  I  +D  DG+C V Y P E G Y +++    + +  SPF   +    + 
Sbjct: 610  GFSVEGPSQAKIECDDKGDGSCDVRYWPQEAGEYAVHVLCNSEDIRLSPFMADIREAPQD 669

Query: 1221 KESITRRQRAPSVANVG----SHCDLSLKIPEISIQDMTAQVTSPSGKSHEAEIVEGENH 1388
                  + R P +   G       + ++         +  QV    G   +A + +  N 
Sbjct: 670  FHPDRVKARGPGLEKTGVAVNKPAEFTVDAKHGGKAALRVQVQDNEGCPVDATVKDNGNG 729

Query: 1389 TYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAH--KVRAGGPGLERA--E 1556
            TY   +VP +   HT  V + G  +P SPF+  VG     G+H  KV+  GPG+ +   +
Sbjct: 730  TYSCSYVPRKPVKHTAMVSWGGVSIPNSPFRVNVG----AGSHPNKVKVYGPGVAKTGLK 785

Query: 1557 AGVPAEFSIWTREAGAGGLAIAVE------GPSKAEISFE--DRKDGSCGVAYVVQEPGD 1712
            A  P  F++   EAG G ++I ++      GP++A+I F+     + +  V Y  +  G 
Sbjct: 786  AHEPTYFTVDCTEAGQGDVSIGIKCAPGVVGPTEADIDFDIIRNDNDTFTVKYTPRGAGS 845

Query: 1713 YEVSVKFNEEHIPDSPFVVPVASPSGDARRLTVS--SLQESGLKVNQPASFAVSLNGA-K 1883
            Y + V F ++  P SP  V V  PS DA ++      L  +G+++ +P  F ++   A K
Sbjct: 846  YTIMVLFADQATPTSPIRVKV-EPSHDASKVKAEGPGLSRTGVELGKPTHFTINAKAAGK 904

Query: 1884 GAIDAKVH--SPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIR 2057
            G  D +    +   A+ +  + +   + Y V++ P + G   I+V + G  IP SPF + 
Sbjct: 905  GKPDVQFSGLAKGDAVRDVDIIDHHDNTYTVKYTPVQQGPVGINVTYGGDPIPKSPFSVG 964

Query: 2058 VGEPGHGGDPGLVSAYGAGLEGGVTGSPAEFIVNTSNAGA-GALSVTIDGPSKVKMDCQE 2234
            V       D   +   G G +  V G   EF V +  AG  G ++  I GPS   + C+ 
Sbjct: 965  VSP---SLDLSKIKVSGLGEKVDV-GKDQEFTVKSKGAGGQGKVASKITGPSGTAVPCKV 1020

Query: 2235 CP----EGYRVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSVF 2402
             P    +   V + P   G Y + + Y G   + GSPF                      
Sbjct: 1021 EPGLGADNSVVRFVPREEGPYEVEVTYDG-VPVPGSPFP--------------------- 1058

Query: 2403 VDSLTKTXXXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKAGNNMLLVGV 2582
            V++L  T                SKV A G GL     G    FT+D   AG   L + V
Sbjct: 1059 VEALPPT--------------KPSKVKAFGPGLQGGSAGSPARFTIDTKGAGMGGLGLTV 1104

Query: 2583 HGPRTPCE-EILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLV 2738
             G   PCE ++     G    SVSY+  + G+Y + + + D HIPGSP++  V
Sbjct: 1105 EG---PCEAQLECLDNGDGTCSVSYVPTEPGDYNINILFADTHIPGSPFKAHV 1154



 Score =  226 bits (577), Expect = 8e-59
 Identities = 230/843 (27%), Positives = 366/843 (43%), Gaps = 50/843 (5%)
 Frame = +3

Query: 354  PGSPLQFYVDYVNCGHVTAYGPGL--SHGVVNKPAVFTVNTKDAGEGGLSLAIEGPS--- 518
            PG+PL+     +N     AYGPG+  +  +V K A FTV T+ AG+G + + +E P+   
Sbjct: 271  PGAPLR---PKLNPKKARAYGPGIEPTGNMVKKRAEFTVETRSAGQGEVLVYVEDPAGHQ 327

Query: 519  -KAEISCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARV--TGDDSMRMSHL 689
             +A+++  ++++ T SV Y+P + G + + V +  QHI  SPF   V  +  D+ +++  
Sbjct: 328  EEAKVTANNDKNRTFSVWYVPEVTGTHKVTVLFAGQHIAKSPFEVYVDKSQGDASKVTAQ 387

Query: 690  KVGSAADIPINISETDLSLLTA---------TVVPPSGRE---EPCLLKRLRNGHVGISF 833
              G      I    T   + TA          +  P+G++   EP L  R  +     S+
Sbjct: 388  GPGLEPSGNIANKTTYFEIFTAGAGTGEVEVVIQDPTGQKGTVEPQLEAR-GDSTYRCSY 446

Query: 834  VPKETGEHLVHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEG--HTFEPAEFI 1007
             P   G H VHV   G  +  SP  V + Q+   +    R  GRGL        E A+F 
Sbjct: 447  QPTMEGVHTVHVTFAGVPIPRSPYTVTVGQA--CNPGACRAVGRGLQPKGVRVKETADFK 504

Query: 1008 IDTRDAGYGGLSLSIEGPSKVD-INTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGS 1184
            + T+ AG G L ++++GP   + +  +DL DG     Y P  PG Y + I +  Q++  S
Sbjct: 505  VYTKGAGSGDLKVTVKGPKGEERVKQKDLGDGVYGFEYYPMVPGTYTVTITWGGQNIGRS 564

Query: 1185 PFSVKVTGE-GRVKESITRRQRAPSVAN--VGSHCDLSLKIPEISIQDMTAQVTSPSGKS 1355
            PF VKV  E G  K     R   P +    VG   D  ++     +  +   V  PS   
Sbjct: 565  PFEVKVGTECGNQKV----RAWGPGLEGGVVGKSADFVVEAIGDDVGTLGFSVEGPSQAK 620

Query: 1356 HEAEIVEGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEG-GAHKVRAG 1532
             E +  +  + +  +R+ P E G + V V    + +  SPF   +    +     +V+A 
Sbjct: 621  IECD--DKGDGSCDVRYWPQEAGEYAVHVLCNSEDIRLSPFMADIREAPQDFHPDRVKAR 678

Query: 1533 GPGLERAEAGV--PAEFSIWTREAGAGGLAIAVEGPS--KAEISFEDRKDGSCGVAYVVQ 1700
            GPGLE+    V  PAEF++  +  G   L + V+       + + +D  +G+   +YV +
Sbjct: 679  GPGLEKTGVAVNKPAEFTVDAKHGGKAALRVQVQDNEGCPVDATVKDNGNGTYSCSYVPR 738

Query: 1701 EPGDYEVSVKFNEEHIPDSPFVVPVASPSGDAR-RLTVSSLQESGLKVNQPASFAVSLNG 1877
            +P  +   V +    IP+SPF V V + S   + ++    + ++GLK ++P  F V    
Sbjct: 739  KPVKHTAMVSWGGVSIPNSPFRVNVGAGSHPNKVKVYGPGVAKTGLKAHEPTYFTVDCTE 798

Query: 1878 A-KGAIDAKVH------SPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIP 2036
            A +G +   +        P+ A  +  +   D D + V++ PR  G Y I V F     P
Sbjct: 799  AGQGDVSIGIKCAPGVVGPTEADIDFDIIRNDNDTFTVKYTPRGAGSYTIMVLFADQATP 858

Query: 2037 GSPFKIRVGEPGHGGDPGLVSAYGAGLE--GGVTGSPAEFIVNTSNAGAGALSVTIDGPS 2210
             SP +++V EP H  D   V A G GL   G   G P  F +N   AG G   V   G +
Sbjct: 859  TSPIRVKV-EPSH--DASKVKAEGPGLSRTGVELGKPTHFTINAKAAGKGKPDVQFSGLA 915

Query: 2211 K----VKMDCQECPEG-YRVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNH 2375
            K      +D  +  +  Y V YTP+  G   I++ YGG   I  SPF   V+        
Sbjct: 916  KGDAVRDVDIIDHHDNTYTVKYTPVQQGPVGINVTYGGD-PIPKSPFSVGVS-------- 966

Query: 2376 SLHETSSVFVDSLTKTXXXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKA 2555
                                            SK+   GLG  K  VG+   FTV    A
Sbjct: 967  ---------------------------PSLDLSKIKVSGLG-EKVDVGKDQEFTVKSKGA 998

Query: 2556 GNN----MLLVGVHGPRTPCEEILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSP 2723
            G        + G  G   PC+  +   +G+    V ++ +++G Y + V +    +PGSP
Sbjct: 999  GGQGKVASKITGPSGTAVPCK--VEPGLGADNSVVRFVPREEGPYEVEVTYDGVPVPGSP 1056

Query: 2724 YRV 2732
            + V
Sbjct: 1057 FPV 1059


>ref|XP_867545.1| PREDICTED: similar to Filamin A (Alpha-filamin) (Filamin 1)
            (Endothelial actin-binding protein) (Actin-binding
            protein 280) (ABP-280) (Nonmuscle filamin) isoform 9
            [Canis familiaris].
          Length = 2619

 Score = 1715 bits (4442), Expect = 0.0
 Identities = 857/913 (93%), Positives = 868/913 (95%)
 Frame = +3

Query: 3    PFQVTALAGEQPSVXXXXXXXXXXXXYTYAQGGQQTWAPERPLVGVNGLDVTSLRPFDLV 182
            PFQVT   G+                   A+G     APERPL+GVNGLDVTSLRPFDLV
Sbjct: 1727 PFQVTVRRGQ-------------------ARGAGVEPAPERPLMGVNGLDVTSLRPFDLV 1767

Query: 183  IPFTIKKGEITGEVRMPSGKVAQPAITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGS 362
            IPFTIKKGEITGEVRMPSGKVAQPAITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGS
Sbjct: 1768 IPFTIKKGEITGEVRMPSGKVAQPAITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGS 1827

Query: 363  PLQFYVDYVNCGHVTAYGPGLSHGVVNKPAVFTVNTKDAGEGGLSLAIEGPSKAEISCTD 542
            PLQFYVDYVNCGHVTAYGPGL+HGVVNKPAVFTVNTKDAGEGGLSLAIEGPSKAEISCTD
Sbjct: 1828 PLQFYVDYVNCGHVTAYGPGLTHGVVNKPAVFTVNTKDAGEGGLSLAIEGPSKAEISCTD 1887

Query: 543  NQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARVTGDDSMRMSHLKVGSAADIPIN 722
            NQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARVTGDDSMRMSHLKVGSAADIPIN
Sbjct: 1888 NQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARVTGDDSMRMSHLKVGSAADIPIN 1947

Query: 723  ISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNGQHVASSP 902
            ISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNGQHVASSP
Sbjct: 1948 ISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNGQHVASSP 2007

Query: 903  IPVVISQSEIGDASRVRVSGRGLHEGHTFEPAEFIIDTRDAGYGGLSLSIEGPSKVDINT 1082
            IPVVISQSEIGDASRVRVSG+GLHEGHTFEPAEFIIDTRDAGYGGLSLSIEGPSKVDINT
Sbjct: 2008 IPVVISQSEIGDASRVRVSGQGLHEGHTFEPAEFIIDTRDAGYGGLSLSIEGPSKVDINT 2067

Query: 1083 EDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTGEGRVKESITRRQRAPSVA 1262
            EDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTGEGRVKESITRR+RAPSVA
Sbjct: 2068 EDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTGEGRVKESITRRRRAPSVA 2127

Query: 1263 NVGSHCDLSLKIPEISIQDMTAQVTSPSGKSHEAEIVEGENHTYCIRFVPAEMGMHTVSV 1442
            NVGSHC+LSLKIPEISIQDMTAQVTSPSGK+HEAEIVEGENHTYCIRFVPAEMGMHTVSV
Sbjct: 2128 NVGSHCNLSLKIPEISIQDMTAQVTSPSGKTHEAEIVEGENHTYCIRFVPAEMGMHTVSV 2187

Query: 1443 KYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLERAEAGVPAEFSIWTREAGAGGLAIA 1622
            KYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLERAEAGVPAEFSIWTREAGAGGLAIA
Sbjct: 2188 KYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLERAEAGVPAEFSIWTREAGAGGLAIA 2247

Query: 1623 VEGPSKAEISFEDRKDGSCGVAYVVQEPGDYEVSVKFNEEHIPDSPFVVPVASPSGDARR 1802
            VEGPSKAEISFEDRKDGSCGVAYVVQEPGDYEVSVKFNEEHIPDSPFVVPVASPSGDARR
Sbjct: 2248 VEGPSKAEISFEDRKDGSCGVAYVVQEPGDYEVSVKFNEEHIPDSPFVVPVASPSGDARR 2307

Query: 1803 LTVSSLQESGLKVNQPASFAVSLNGAKGAIDAKVHSPSGALEECYVTEIDQDKYAVRFIP 1982
            LTVSSLQESGLKVNQPASFAVSLNGAKGAIDAKVHSPSGALEECYVTEIDQDKYAVRFIP
Sbjct: 2308 LTVSSLQESGLKVNQPASFAVSLNGAKGAIDAKVHSPSGALEECYVTEIDQDKYAVRFIP 2367

Query: 1983 RENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPGLVSAYGAGLEGGVTGSPAEFIVNT 2162
            RENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPGLVSAYGAGLEGGVTGSPAEFIVNT
Sbjct: 2368 RENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPGLVSAYGAGLEGGVTGSPAEFIVNT 2427

Query: 2163 SNAGAGALSVTIDGPSKVKMDCQECPEGYRVTYTPMAPGSYLISIKYGGPYHIGGSPFKA 2342
            SNAGAGALSVTIDGPSKVKMDCQECPEGYRVTYTPMAPGSYLISIKYGGPYHIGGSPFKA
Sbjct: 2428 SNAGAGALSVTIDGPSKVKMDCQECPEGYRVTYTPMAPGSYLISIKYGGPYHIGGSPFKA 2487

Query: 2343 RVTGHRLVSNHSLHETSSVFVDSLTKTXXXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQ 2522
            +VTG RLVSNHSLHETSSVFVDSLTKT                SKVLAKGLGLSKAYVGQ
Sbjct: 2488 KVTGPRLVSNHSLHETSSVFVDSLTKT-ASAPQHGALAGSTDASKVLAKGLGLSKAYVGQ 2546

Query: 2523 KGSFTVDCSKAGNNMLLVGVHGPRTPCEEILVKHVGSRLYSVSYLLKDKGEYTLVVKWGD 2702
            K SFTVDCSKAGNNMLLVGVHGPRTPCEEILVKHVG+RLY+VSYLLKDKGEYTLVVKWGD
Sbjct: 2547 KSSFTVDCSKAGNNMLLVGVHGPRTPCEEILVKHVGNRLYNVSYLLKDKGEYTLVVKWGD 2606

Query: 2703 EHIPGSPYRVLVP 2741
            EHIPGSPYRVLVP
Sbjct: 2607 EHIPGSPYRVLVP 2619



 Score =  320 bits (819), Expect = 7e-87
 Identities = 230/758 (30%), Positives = 360/758 (47%), Gaps = 38/758 (5%)
 Frame = +3

Query: 189  FTIK------KGEITGEVRMPSG-----KVAQPAITDNKDGTVTVRYAPSEAGLHEMDIR 335
            FT+K      +G++  ++  PSG     KV      DN      VR+ P E G +E+++ 
Sbjct: 991  FTVKSKGAGGQGKVASKITGPSGTAVPCKVEPGLGADNS----VVRFVPREEGPYEVEVT 1046

Query: 336  YDNMHIPGSPLQFY-VDYVNCGHVTAYGPGLSHGVVNKPAVFTVNTKDAGEGGLSLAIEG 512
            YD + +PGSP     +       V A+GPGL  G    PA FT++TK AG GGL L +EG
Sbjct: 1047 YDGVPVPGSPFPVEALPPTKPSKVKAFGPGLQGGSAGSPARFTIDTKGAGMGGLGLTVEG 1106

Query: 513  PSKAEISCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARVTG--DDSM---- 674
            P +A++ C DN DGTCSVSY+P  PGDY+I + + + HIPGSPF A V    D S     
Sbjct: 1107 PCEAQLECLDNGDGTCSVSYVPTEPGDYNINILFADTHIPGSPFKAHVVPCFDASKVKCS 1166

Query: 675  --RMSHLKVGSAADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKET 848
               +     G A    ++ S    + LT  +   +G      ++   +G   I+++P   
Sbjct: 1167 GPGLERATAGEAGQFHVDCSSAGSAELTIEIRSEAGLPAEVHIQDHGDGTHTITYIPLCP 1226

Query: 849  GEHLVHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEGHTFEPA--EFIIDTR- 1019
            G + V +K  GQ V + P  + +  +   D S V+  G G+     F  A  EF +D R 
Sbjct: 1227 GAYTVTIKYGGQPVPNFPSKLQVEPAV--DTSGVQCYGPGIEGQGVFREATTEFSVDARA 1284

Query: 1020 --DAGYGGLSLSIEGPS--KVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSP 1187
                G   +   +  PS    +   +D  DGT +V Y P E G + +++ +    VP SP
Sbjct: 1285 LTQTGGPHVKARVANPSGNLTETYVQDCGDGTYKVEYTPYEEGLHSVDVTYDGSPVPSSP 1344

Query: 1188 FSVKVTGEGRVKESITRRQRAPSVANVGSHCDLSLKIPEISIQDMTAQVTSPSGKSHEAE 1367
            F V VT EG     +                  +++        +   V  PS    +  
Sbjct: 1345 FQVPVT-EGCDPSRVRVHGPGIQSGTTNKPNKFTVETRGAGTGGLGLAVEGPS--EAKMS 1401

Query: 1368 IVEGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLE 1547
             ++ ++ +  + ++P E G ++++V Y G  VPGSPF+  V  + +  A KV+  GPGL 
Sbjct: 1402 CMDNKDGSCSVEYIPYEAGTYSLNVTYGGHQVPGSPFKVPVHDVTD--ASKVKCSGPGLS 1459

Query: 1548 --RAEAGVPAEFSIWTREAGAGGLAIAVEGPS--KAEISFEDRKDGSCGVAYVVQEPGDY 1715
                 A +P  F + T +AG   L + V+GP      +   D  DG+  V YV    G Y
Sbjct: 1460 PGMVRANLPQSFQVDTSKAGVAPLQVKVQGPKGLVEPVDVVDNADGTQTVNYVPSREGPY 1519

Query: 1716 EVSVKFNEEHIPDSPFVVPVASPSGDARRLTVS--SLQESGLKVNQPASFAVSLNGA-KG 1886
             +SV + EE +P SPF V V  P+ DA ++  S   L  +G+  + P  F +    A +G
Sbjct: 1520 SISVLYGEEEVPRSPFKVKVL-PTHDASKVKASGPGLNTTGVPASLPVEFTIDAKDAGEG 1578

Query: 1887 AIDAKVHSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGE 2066
             +  ++  P G  ++ ++ +     Y V ++P   G Y I +K+ G  IP SP+++R   
Sbjct: 1579 LLAVQITDPEGKPKKTHIQDNHDGTYTVAYVPDVTGRYTILIKYGGDEIPFSPYRVRAVP 1638

Query: 2067 PGHGGDPGLVSAYGAGLEGGV-TGSPAEFIVNTSNAGAGALSVTIDGP--SKVKMDCQEC 2237
                GD    +  GAG+   +  G      V+T  AG G ++ T+  P  S+V +D  E 
Sbjct: 1639 T---GDASKCTVTGAGIGPTIQIGEETVITVDTKAAGKGKVTCTVCTPDGSEVDVDVVEN 1695

Query: 2238 PEG-YRVTYTPMAPGSYLISIKYGGPYHIGGSPFKARV 2348
             +G + + YT   PG Y+I +++GG  H+  SPF+  V
Sbjct: 1696 EDGTFDIFYTAPQPGKYVICVRFGGE-HVPNSPFQVTV 1732



 Score =  300 bits (769), Expect = 4e-81
 Identities = 252/895 (28%), Positives = 405/895 (45%), Gaps = 49/895 (5%)
 Frame = +3

Query: 201  KGEITGEVRMPSGKVAQPAITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFYV 380
            K  +  +V+   G      + DN +GT +  Y P +   H   + +  + IP SP +  V
Sbjct: 704  KAALRVQVQDNEGCPVDATVKDNGNGTYSCSYVPRKPVKHTAMVSWGGVSIPNSPFRVNV 763

Query: 381  DY-VNCGHVTAYGPGLSHGVV--NKPAVFTVNTKDAGEGGLSLAIE------GPSKAEIS 533
                +   V  YGPG++   +  ++P  FTV+  +AG+G +S+ I+      GP++A+I 
Sbjct: 764  GAGSHPNKVKVYGPGVAKTGLKAHEPTYFTVDCTEAGQGDVSIGIKCAPGVVGPTEADID 823

Query: 534  --CTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARVTGDDSMRMSHLKVGSAA 707
                 N + T +V Y P   G Y+I+V + +Q  P SP   +V        SH      A
Sbjct: 824  FDIIRNDNDTFTVKYTPRGAGSYTIMVLFADQATPTSPIRVKV------EPSHDASKVKA 877

Query: 708  DIPINISETDLSLLTATV----VPPSGREEPCL-LKRLRNGHV--------------GIS 830
            + P  +S T + L   T        +G+ +P +    L  G                 + 
Sbjct: 878  EGP-GLSRTGVELGKPTHFTINAKAAGKGKPDVQFSGLAKGDAVRDVDIIDHHDNTYTVK 936

Query: 831  FVPKETGEHLVHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEGHTFEPAEFII 1010
            + P + G   ++V   G  +  SP  V +S S   D S+++VSG G  +    +  EF +
Sbjct: 937  YTPVQQGPVGINVTYGGDPIPKSPFSVGVSPSL--DLSKIKVSGLG-EKVDVGKDQEFTV 993

Query: 1011 DTRDAG-YGGLSLSIEGPSKVDINTEDLEDG----TCRVTYCPTEPGNYIINIKFADQHV 1175
             ++ AG  G ++  I GPS   +  + +E G       V + P E G Y + + +    V
Sbjct: 994  KSKGAGGQGKVASKITGPSGTAVPCK-VEPGLGADNSVVRFVPREEGPYEVEVTYDGVPV 1052

Query: 1176 PGSPFSVKV---TGEGRVKESITRRQRAPSVANVGSHCDLSLKIPEISIQDMTAQVTSPS 1346
            PGSPF V+    T   +VK      Q      + GS    ++      +  +   V  P 
Sbjct: 1053 PGSPFPVEALPPTKPSKVKAFGPGLQGG----SAGSPARFTIDTKGAGMGGLGLTVEGPC 1108

Query: 1347 GKSHEAEIVEGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVR 1526
                + E ++  + T  + +VP E G + +++ +   H+PGSPF+  V P  +  A KV+
Sbjct: 1109 --EAQLECLDNGDGTCSVSYVPTEPGDYNINILFADTHIPGSPFKAHVVPCFD--ASKVK 1164

Query: 1527 AGGPGLERAEAGVPAEFSIWTREAGAGGLAIAV--EGPSKAEISFEDRKDGSCGVAYVVQ 1700
              GPGLERA AG   +F +    AG+  L I +  E    AE+  +D  DG+  + Y+  
Sbjct: 1165 CSGPGLERATAGEAGQFHVDCSSAGSAELTIEIRSEAGLPAEVHIQDHGDGTHTITYIPL 1224

Query: 1701 EPGDYEVSVKFNEEHIPDSPFVVPVASPSGDARRLTV--SSLQESGLKVNQPASFAVSLN 1874
             PG Y V++K+  + +P+ P  + V  P+ D   +      ++  G+       F+V   
Sbjct: 1225 CPGAYTVTIKYGGQPVPNFPSKLQV-EPAVDTSGVQCYGPGIEGQGVFREATTEFSVDAR 1283

Query: 1875 GAKGA----IDAKVHSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGS 2042
                     + A+V +PSG L E YV +     Y V + P E G++ +DV ++G+ +P S
Sbjct: 1284 ALTQTGGPHVKARVANPSGNLTETYVQDCGDGTYKVEYTPYEEGLHSVDVTYDGSPVPSS 1343

Query: 2043 PFKIRVGEPGHGGDPGLVSAYGAGLEGGVTGSPAEFIVNTSNAGAGALSVTIDGPSKVKM 2222
            PF++ V E   G DP  V  +G G++ G T  P +F V T  AG G L + ++GPS+ KM
Sbjct: 1344 PFQVPVTE---GCDPSRVRVHGPGIQSGTTNKPNKFTVETRGAGTGGLGLAVEGPSEAKM 1400

Query: 2223 DCQECPEGY-RVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSV 2399
             C +  +G   V Y P   G+Y +++ YGG + + GSPFK  V           H+ +  
Sbjct: 1401 SCMDNKDGSCSVEYIPYEAGTYSLNVTYGG-HQVPGSPFKVPV-----------HDVTDA 1448

Query: 2400 FVDSLTKTXXXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQK--GSFTVDCSKAGNNMLL 2573
                                    SKV   G GLS   V      SF VD SKAG   L 
Sbjct: 1449 ------------------------SKVKCSGPGLSPGMVRANLPQSFQVDTSKAGVAPLQ 1484

Query: 2574 VGVHGPRTPCEEILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLV 2738
            V V GP+   E + V        +V+Y+   +G Y++ V +G+E +P SP++V V
Sbjct: 1485 VKVQGPKGLVEPVDVVDNADGTQTVNYVPSREGPYSISVLYGEEEVPRSPFKVKV 1539



 Score =  286 bits (733), Expect = 6e-77
 Identities = 248/893 (27%), Positives = 386/893 (43%), Gaps = 47/893 (5%)
 Frame = +3

Query: 201  KGEITGEVRMPSGKVAQPAITDNKDG--TVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQF 374
            +GE+   V  P+G   +  +T N D   T +V Y P   G H++ + +   HI  SP + 
Sbjct: 313  QGEVLVYVEDPAGHQEEAKVTANNDKNRTFSVWYVPEVTGTHKVTVLFAGQHIAKSPFEV 372

Query: 375  YVD--YVNCGHVTAYGPGL--SHGVVNKPAVFTVNTKDAGEGGLSLAIEGPS----KAEI 530
            YVD    +   VTA GPGL  S  + NK   F + T  AG G + + I+ P+      E 
Sbjct: 373  YVDKSQGDASKVTAQGPGLEPSGNIANKTTYFEIFTAGAGTGEVEVVIQDPTGQKGTVEP 432

Query: 531  SCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARV----------TGDDSMRM 680
                  D T   SY P + G +++ V +    IP SP+T  V               ++ 
Sbjct: 433  QLEARGDSTYRCSYQPTMEGVHTVHVTFAGVPIPRSPYTVTVGQACNPGACRAVGRGLQP 492

Query: 681  SHLKVGSAADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHL 860
              ++V   AD  +         L  TV  P G EE    K L +G  G  + P   G + 
Sbjct: 493  KGVRVKETADFKVYTKGAGSGDLKVTVKGPKG-EERVKQKDLGDGVYGFEYYPMVPGTYT 551

Query: 861  VHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEGHTFEPAEFIIDTRDAGYGGL 1040
            V +   GQ++  SP  V +  +E G+  +VR  G GL  G   + A+F+++      G L
Sbjct: 552  VTITWGGQNIGRSPFEVKVG-TECGN-QKVRAWGPGLEGGVVGKSADFVVEAIGDDVGTL 609

Query: 1041 SLSIEGPSKVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTGEGRV 1220
              S+EGPS+  I  +D  DG+C V Y P E G Y +++    + +  SPF   +    + 
Sbjct: 610  GFSVEGPSQAKIECDDKGDGSCDVRYWPQEAGEYAVHVLCNSEDIRLSPFMADIREAPQD 669

Query: 1221 KESITRRQRAPSVANVG----SHCDLSLKIPEISIQDMTAQVTSPSGKSHEAEIVEGENH 1388
                  + R P +   G       + ++         +  QV    G   +A + +  N 
Sbjct: 670  FHPDRVKARGPGLEKTGVAVNKPAEFTVDAKHGGKAALRVQVQDNEGCPVDATVKDNGNG 729

Query: 1389 TYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAH--KVRAGGPGLERA--E 1556
            TY   +VP +   HT  V + G  +P SPF+  VG     G+H  KV+  GPG+ +   +
Sbjct: 730  TYSCSYVPRKPVKHTAMVSWGGVSIPNSPFRVNVG----AGSHPNKVKVYGPGVAKTGLK 785

Query: 1557 AGVPAEFSIWTREAGAGGLAIAVE------GPSKAEISFE--DRKDGSCGVAYVVQEPGD 1712
            A  P  F++   EAG G ++I ++      GP++A+I F+     + +  V Y  +  G 
Sbjct: 786  AHEPTYFTVDCTEAGQGDVSIGIKCAPGVVGPTEADIDFDIIRNDNDTFTVKYTPRGAGS 845

Query: 1713 YEVSVKFNEEHIPDSPFVVPVASPSGDARRLTVS--SLQESGLKVNQPASFAVSLNGA-K 1883
            Y + V F ++  P SP  V V  PS DA ++      L  +G+++ +P  F ++   A K
Sbjct: 846  YTIMVLFADQATPTSPIRVKV-EPSHDASKVKAEGPGLSRTGVELGKPTHFTINAKAAGK 904

Query: 1884 GAIDAKVH--SPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIR 2057
            G  D +    +   A+ +  + +   + Y V++ P + G   I+V + G  IP SPF + 
Sbjct: 905  GKPDVQFSGLAKGDAVRDVDIIDHHDNTYTVKYTPVQQGPVGINVTYGGDPIPKSPFSVG 964

Query: 2058 VGEPGHGGDPGLVSAYGAGLEGGVTGSPAEFIVNTSNAGA-GALSVTIDGPSKVKMDCQE 2234
            V       D   +   G G +  V G   EF V +  AG  G ++  I GPS   + C+ 
Sbjct: 965  VSP---SLDLSKIKVSGLGEKVDV-GKDQEFTVKSKGAGGQGKVASKITGPSGTAVPCKV 1020

Query: 2235 CP----EGYRVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSVF 2402
             P    +   V + P   G Y + + Y G   + GSPF                      
Sbjct: 1021 EPGLGADNSVVRFVPREEGPYEVEVTYDG-VPVPGSPFP--------------------- 1058

Query: 2403 VDSLTKTXXXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKAGNNMLLVGV 2582
            V++L  T                SKV A G GL     G    FT+D   AG   L + V
Sbjct: 1059 VEALPPT--------------KPSKVKAFGPGLQGGSAGSPARFTIDTKGAGMGGLGLTV 1104

Query: 2583 HGPRTPCE-EILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLV 2738
             G   PCE ++     G    SVSY+  + G+Y + + + D HIPGSP++  V
Sbjct: 1105 EG---PCEAQLECLDNGDGTCSVSYVPTEPGDYNINILFADTHIPGSPFKAHV 1154



 Score =  273 bits (699), Expect = 6e-73
 Identities = 241/887 (27%), Positives = 384/887 (43%), Gaps = 42/887 (4%)
 Frame = +3

Query: 204  GEITGEVRMPSGKVAQPAITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFYVD 383
            G++   V+ P G+  +    D  DG     Y P   G + + I +   +I  SP +  V 
Sbjct: 513  GDLKVTVKGPKGE-ERVKQKDLGDGVYGFEYYPMVPGTYTVTITWGGQNIGRSPFEVKVG 571

Query: 384  YVNCGH--VTAYGPGLSHGVVNKPAVFTVNTKDAGEGGLSLAIEGPSKAEISCTDNQDGT 557
               CG+  V A+GPGL  GVV K A F V       G L  ++EGPS+A+I C D  DG+
Sbjct: 572  -TECGNQKVRAWGPGLEGGVVGKSADFVVEAIGDDVGTLGFSVEGPSQAKIECDDKGDGS 630

Query: 558  CSVSYLPVLPGDYSILVKYNEQHIPGSPFTARV-------------TGDDSMRMSHLKVG 698
            C V Y P   G+Y++ V  N + I  SPF A +                  +  + + V 
Sbjct: 631  CDVRYWPQEAGEYAVHVLCNSEDIRLSPFMADIREAPQDFHPDRVKARGPGLEKTGVAVN 690

Query: 699  SAADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKN 878
              A+  ++      + L   V    G      +K   NG    S+VP++  +H   V   
Sbjct: 691  KPAEFTVDAKHGGKAALRVQVQDNEGCPVDATVKDNGNGTYSCSYVPRKPVKHTAMVSWG 750

Query: 879  GQHVASSPIPVVISQSEIGDASRVRVSGRGLHEG--HTFEPAEFIIDTRDAGYGGLSLSI 1052
            G  + +SP  V +        ++V+V G G+ +      EP  F +D  +AG G +S+ I
Sbjct: 751  GVSIPNSPFRVNVGAG--SHPNKVKVYGPGVAKTGLKAHEPTYFTVDCTEAGQGDVSIGI 808

Query: 1053 E------GPSKVDINTEDL--EDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVT- 1205
            +      GP++ DI+ + +  ++ T  V Y P   G+Y I + FADQ  P SP  VKV  
Sbjct: 809  KCAPGVVGPTEADIDFDIIRNDNDTFTVKYTPRGAGSYTIMVLFADQATPTSPIRVKVEP 868

Query: 1206 --GEGRVKESITRRQRAPSVANVGSHCDLSLKIPEISIQDMTAQVTSPSGKSHEAEIVEG 1379
                 +VK       R        +H  ++ K       D+     +      + +I++ 
Sbjct: 869  SHDASKVKAEGPGLSRTGVELGKPTHFTINAKAAGKGKPDVQFSGLAKGDAVRDVDIIDH 928

Query: 1380 ENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLERAEA 1559
             ++TY +++ P + G   ++V Y G  +P SPF   V P  +    K++  G G E+ + 
Sbjct: 929  HDNTYTVKYTPVQQGPVGINVTYGGDPIPKSPFSVGVSPSLD--LSKIKVSGLG-EKVDV 985

Query: 1560 GVPAEFSIWTREAGA-GGLAIAVEGPSKAEISFEDR----KDGSCGVAYVVQEPGDYEVS 1724
            G   EF++ ++ AG  G +A  + GPS   +  +       D S  V +V +E G YEV 
Sbjct: 986  GKDQEFTVKSKGAGGQGKVASKITGPSGTAVPCKVEPGLGADNSV-VRFVPREEGPYEVE 1044

Query: 1725 VKFNEEHIPDSPFVVPVASPSGDARRLTVSSLQESGLKVNQPASFAVSLNGA-KGAIDAK 1901
            V ++   +P SPF V    P+  ++        + G     PA F +   GA  G +   
Sbjct: 1045 VTYDGVPVPGSPFPVEALPPTKPSKVKAFGPGLQGG-SAGSPARFTIDTKGAGMGGLGLT 1103

Query: 1902 VHSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGG 2081
            V  P  A  EC   +      +V ++P E G Y I++ F  THIPGSPFK  V       
Sbjct: 1104 VEGPCEAQLEC--LDNGDGTCSVSYVPTEPGDYNINILFADTHIPGSPFKAHVVP---CF 1158

Query: 2082 DPGLVSAYGAGLEGGVTGSPAEFIVNTSNAGAGALSVTI--DGPSKVKMDCQECPEG-YR 2252
            D   V   G GLE    G   +F V+ S+AG+  L++ I  +     ++  Q+  +G + 
Sbjct: 1159 DASKVKCSGPGLERATAGEAGQFHVDCSSAGSAELTIEIRSEAGLPAEVHIQDHGDGTHT 1218

Query: 2253 VTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSVFVDSLTKTXXX 2432
            +TY P+ PG+Y ++IKYGG   +   P K +V                  VD+       
Sbjct: 1219 ITYIPLCPGAYTVTIKYGG-QPVPNFPSKLQV---------------EPAVDT------- 1255

Query: 2433 XXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGS--FTVDC---SKAGNNMLLVGVHGPRT 2597
                         S V   G G+    V ++ +  F+VD    ++ G   +   V  P  
Sbjct: 1256 -------------SGVQCYGPGIEGQGVFREATTEFSVDARALTQTGGPHVKARVANPSG 1302

Query: 2598 PCEEILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLV 2738
               E  V+  G   Y V Y   ++G +++ V +    +P SP++V V
Sbjct: 1303 NLTETYVQDCGDGTYKVEYTPYEEGLHSVDVTYDGSPVPSSPFQVPV 1349



 Score =  263 bits (671), Expect = 1e-69
 Identities = 238/874 (27%), Positives = 376/874 (43%), Gaps = 34/874 (3%)
 Frame = +3

Query: 219  EVRMPSGKVAQPAITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFYV-DYVNC 395
            +V+ P G V    + DN DGT TV Y PS  G + + + Y    +P SP +  V    + 
Sbjct: 1486 KVQGPKGLVEPVDVVDNADGTQTVNYVPSREGPYSISVLYGEEEVPRSPFKVKVLPTHDA 1545

Query: 396  GHVTAYGPGLSHGVV--NKPAVFTVNTKDAGEGGLSLAI---EG-PSKAEISCTDNQDGT 557
              V A GPGL+   V  + P  FT++ KDAGEG L++ I   EG P K  I   DN DGT
Sbjct: 1546 SKVKASGPGLNTTGVPASLPVEFTIDAKDAGEGLLAVQITDPEGKPKKTHIQ--DNHDGT 1603

Query: 558  CSVSYLPVLPGDYSILVKYNEQHIPGSPFTARV--TGDDSMRM-------SHLKVGSAAD 710
             +V+Y+P + G Y+IL+KY    IP SP+  R   TGD S            +++G    
Sbjct: 1604 YTVAYVPDVTGRYTILIKYGGDEIPFSPYRVRAVPTGDASKCTVTGAGIGPTIQIGEETV 1663

Query: 711  IPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNGQHV 890
            I ++        +T TV  P G E    +    +G   I +   + G++++ V+  G+HV
Sbjct: 1664 ITVDTKAAGKGKVTCTVCTPDGSEVDVDVVENEDGTFDIFYTAPQPGKYVICVRFGGEHV 1723

Query: 891  ASSPIPVVISQSEIGDA------SRVRVSGRGLHEGHTFEPAEFIIDTRDAGYGGLSLSI 1052
             +SP  V + + +   A       R  +   GL +  +  P + +I       G ++  +
Sbjct: 1724 PNSPFQVTVRRGQARGAGVEPAPERPLMGVNGL-DVTSLRPFDLVIPF-TIKKGEITGEV 1781

Query: 1053 EGPS--KVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSP--FSVKVTGEGRV 1220
              PS         D +DGT  V Y P+E G + ++I++ + H+PGSP  F V     G V
Sbjct: 1782 RMPSGKVAQPAITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFYVDYVNCGHV 1841

Query: 1221 KESITRRQRAPSVANVGSHCDLSLKIPEISIQDMTAQVTSPSGKSHEAEIVEGENHTYCI 1400
                T      +   V      ++   +     ++  +  PS    E    + ++ T  +
Sbjct: 1842 ----TAYGPGLTHGVVNKPAVFTVNTKDAGEGGLSLAIEGPS--KAEISCTDNQDGTCSV 1895

Query: 1401 RFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLERAEAGVPAEFS 1580
             ++P   G +++ VKY  QH+PGSPF   V      G   +R     +   + G  A+  
Sbjct: 1896 SYLPVLPGDYSILVKYNEQHIPGSPFTARV-----TGDDSMR-----MSHLKVGSAADIP 1945

Query: 1581 IWTREAGAGGLAIAVEGPSKAE--ISFEDRKDGSCGVAYVVQEPGDYEVSVKFNEEHIPD 1754
            I   E     L   V  PS  E     +  ++G  G+++V +E G++ V VK N +H+  
Sbjct: 1946 INISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNGQHVAS 2005

Query: 1755 SPFVVPVA-SPSGDARRLTVSSLQESGLKVNQPASFAVSLNGA-KGAIDAKVHSPSGALE 1928
            SP  V ++ S  GDA R+ VS          +PA F +    A  G +   +  PS    
Sbjct: 2006 SPIPVVISQSEIGDASRVRVSGQGLHEGHTFEPAEFIIDTRDAGYGGLSLSIEGPSKV-- 2063

Query: 1929 ECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPGLVSAYG 2108
            +    +++     V + P E G Y+I++KF   H+PGSPF ++V   G G     ++   
Sbjct: 2064 DINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKV--TGEGRVKESITRRR 2121

Query: 2109 AGLEGGVTGSPAEFIVNTSNAGAGALSVTIDGPSKVKMDCQECPEG----YRVTYTPMAP 2276
                    GS     +         ++  +  PS  K    E  EG    Y + + P   
Sbjct: 2122 RAPSVANVGSHCNLSLKIPEISIQDMTAQVTSPSG-KTHEAEIVEGENHTYCIRFVPAEM 2180

Query: 2277 GSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSVFVDSLTKTXXXXXXXXXXX 2456
            G + +S+KY G  H+ GSPF+  V                                    
Sbjct: 2181 GMHTVSVKYKG-QHVPGSPFQFTV---------------------------------GPL 2206

Query: 2457 XXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKAGNNMLLVGVHGPRTPCEEILVKHVGSR 2636
                  KV A G GL +A  G    F++   +AG   L + V GP     EI  +     
Sbjct: 2207 GEGGAHKVRAGGPGLERAEAGVPAEFSIWTREAGAGGLAIAVEGPSK--AEISFEDRKDG 2264

Query: 2637 LYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLV 2738
               V+Y++++ G+Y + VK+ +EHIP SP+ V V
Sbjct: 2265 SCGVAYVVQEPGDYEVSVKFNEEHIPDSPFVVPV 2298



 Score =  226 bits (577), Expect = 8e-59
 Identities = 230/843 (27%), Positives = 366/843 (43%), Gaps = 50/843 (5%)
 Frame = +3

Query: 354  PGSPLQFYVDYVNCGHVTAYGPGL--SHGVVNKPAVFTVNTKDAGEGGLSLAIEGPS--- 518
            PG+PL+     +N     AYGPG+  +  +V K A FTV T+ AG+G + + +E P+   
Sbjct: 271  PGAPLR---PKLNPKKARAYGPGIEPTGNMVKKRAEFTVETRSAGQGEVLVYVEDPAGHQ 327

Query: 519  -KAEISCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARV--TGDDSMRMSHL 689
             +A+++  ++++ T SV Y+P + G + + V +  QHI  SPF   V  +  D+ +++  
Sbjct: 328  EEAKVTANNDKNRTFSVWYVPEVTGTHKVTVLFAGQHIAKSPFEVYVDKSQGDASKVTAQ 387

Query: 690  KVGSAADIPINISETDLSLLTA---------TVVPPSGRE---EPCLLKRLRNGHVGISF 833
              G      I    T   + TA          +  P+G++   EP L  R  +     S+
Sbjct: 388  GPGLEPSGNIANKTTYFEIFTAGAGTGEVEVVIQDPTGQKGTVEPQLEAR-GDSTYRCSY 446

Query: 834  VPKETGEHLVHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEG--HTFEPAEFI 1007
             P   G H VHV   G  +  SP  V + Q+   +    R  GRGL        E A+F 
Sbjct: 447  QPTMEGVHTVHVTFAGVPIPRSPYTVTVGQA--CNPGACRAVGRGLQPKGVRVKETADFK 504

Query: 1008 IDTRDAGYGGLSLSIEGPSKVD-INTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGS 1184
            + T+ AG G L ++++GP   + +  +DL DG     Y P  PG Y + I +  Q++  S
Sbjct: 505  VYTKGAGSGDLKVTVKGPKGEERVKQKDLGDGVYGFEYYPMVPGTYTVTITWGGQNIGRS 564

Query: 1185 PFSVKVTGE-GRVKESITRRQRAPSVAN--VGSHCDLSLKIPEISIQDMTAQVTSPSGKS 1355
            PF VKV  E G  K     R   P +    VG   D  ++     +  +   V  PS   
Sbjct: 565  PFEVKVGTECGNQKV----RAWGPGLEGGVVGKSADFVVEAIGDDVGTLGFSVEGPSQAK 620

Query: 1356 HEAEIVEGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEG-GAHKVRAG 1532
             E +  +  + +  +R+ P E G + V V    + +  SPF   +    +     +V+A 
Sbjct: 621  IECD--DKGDGSCDVRYWPQEAGEYAVHVLCNSEDIRLSPFMADIREAPQDFHPDRVKAR 678

Query: 1533 GPGLERAEAGV--PAEFSIWTREAGAGGLAIAVEGPS--KAEISFEDRKDGSCGVAYVVQ 1700
            GPGLE+    V  PAEF++  +  G   L + V+       + + +D  +G+   +YV +
Sbjct: 679  GPGLEKTGVAVNKPAEFTVDAKHGGKAALRVQVQDNEGCPVDATVKDNGNGTYSCSYVPR 738

Query: 1701 EPGDYEVSVKFNEEHIPDSPFVVPVASPSGDAR-RLTVSSLQESGLKVNQPASFAVSLNG 1877
            +P  +   V +    IP+SPF V V + S   + ++    + ++GLK ++P  F V    
Sbjct: 739  KPVKHTAMVSWGGVSIPNSPFRVNVGAGSHPNKVKVYGPGVAKTGLKAHEPTYFTVDCTE 798

Query: 1878 A-KGAIDAKVH------SPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIP 2036
            A +G +   +        P+ A  +  +   D D + V++ PR  G Y I V F     P
Sbjct: 799  AGQGDVSIGIKCAPGVVGPTEADIDFDIIRNDNDTFTVKYTPRGAGSYTIMVLFADQATP 858

Query: 2037 GSPFKIRVGEPGHGGDPGLVSAYGAGLE--GGVTGSPAEFIVNTSNAGAGALSVTIDGPS 2210
             SP +++V EP H  D   V A G GL   G   G P  F +N   AG G   V   G +
Sbjct: 859  TSPIRVKV-EPSH--DASKVKAEGPGLSRTGVELGKPTHFTINAKAAGKGKPDVQFSGLA 915

Query: 2211 K----VKMDCQECPEG-YRVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNH 2375
            K      +D  +  +  Y V YTP+  G   I++ YGG   I  SPF   V+        
Sbjct: 916  KGDAVRDVDIIDHHDNTYTVKYTPVQQGPVGINVTYGGD-PIPKSPFSVGVS-------- 966

Query: 2376 SLHETSSVFVDSLTKTXXXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKA 2555
                                            SK+   GLG  K  VG+   FTV    A
Sbjct: 967  ---------------------------PSLDLSKIKVSGLG-EKVDVGKDQEFTVKSKGA 998

Query: 2556 GNN----MLLVGVHGPRTPCEEILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSP 2723
            G        + G  G   PC+  +   +G+    V ++ +++G Y + V +    +PGSP
Sbjct: 999  GGQGKVASKITGPSGTAVPCK--VEPGLGADNSVVRFVPREEGPYEVEVTYDGVPVPGSP 1056

Query: 2724 YRV 2732
            + V
Sbjct: 1057 FPV 1059


>ref|XP_867567.1| PREDICTED: similar to Filamin A (Alpha-filamin) (Filamin 1)
            (Endothelial actin-binding protein) (Actin-binding
            protein 280) (ABP-280) (Nonmuscle filamin) isoform 11
            [Canis familiaris].
          Length = 2614

 Score = 1715 bits (4441), Expect = 0.0
 Identities = 850/879 (96%), Positives = 859/879 (97%)
 Frame = +3

Query: 105  QTWAPERPLVGVNGLDVTSLRPFDLVIPFTIKKGEITGEVRMPSGKVAQPAITDNKDGTV 284
            Q  APERPL+GVNGLDVTSLRPFDLVIPFTIKKGEITGEVRMPSGKVAQPAITDNKDGTV
Sbjct: 1737 QVTAPERPLMGVNGLDVTSLRPFDLVIPFTIKKGEITGEVRMPSGKVAQPAITDNKDGTV 1796

Query: 285  TVRYAPSEAGLHEMDIRYDNMHIPGSPLQFYVDYVNCGHVTAYGPGLSHGVVNKPAVFTV 464
            TVRYAPSEAGLHEMDIRYDNMHIPGSPLQFYVDYVNCGHVTAYGPGL+HGVVNKPAVFTV
Sbjct: 1797 TVRYAPSEAGLHEMDIRYDNMHIPGSPLQFYVDYVNCGHVTAYGPGLTHGVVNKPAVFTV 1856

Query: 465  NTKDAGEGGLSLAIEGPSKAEISCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPF 644
            NTKDAGEGGLSLAIEGPSKAEISCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPF
Sbjct: 1857 NTKDAGEGGLSLAIEGPSKAEISCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPF 1916

Query: 645  TARVTGDDSMRMSHLKVGSAADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVG 824
            TARVTGDDSMRMSHLKVGSAADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVG
Sbjct: 1917 TARVTGDDSMRMSHLKVGSAADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVG 1976

Query: 825  ISFVPKETGEHLVHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEGHTFEPAEF 1004
            ISFVPKETGEHLVHVKKNGQHVASSPIPVVISQSEIGDASRVRVSG+GLHEGHTFEPAEF
Sbjct: 1977 ISFVPKETGEHLVHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGQGLHEGHTFEPAEF 2036

Query: 1005 IIDTRDAGYGGLSLSIEGPSKVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGS 1184
            IIDTRDAGYGGLSLSIEGPSKVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGS
Sbjct: 2037 IIDTRDAGYGGLSLSIEGPSKVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGS 2096

Query: 1185 PFSVKVTGEGRVKESITRRQRAPSVANVGSHCDLSLKIPEISIQDMTAQVTSPSGKSHEA 1364
            PFSVKVTGEGRVKESITRR+RAPSVANVGSHC+LSLKIPEISIQDMTAQVTSPSGK+HEA
Sbjct: 2097 PFSVKVTGEGRVKESITRRRRAPSVANVGSHCNLSLKIPEISIQDMTAQVTSPSGKTHEA 2156

Query: 1365 EIVEGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGL 1544
            EIVEGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGL
Sbjct: 2157 EIVEGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGL 2216

Query: 1545 ERAEAGVPAEFSIWTREAGAGGLAIAVEGPSKAEISFEDRKDGSCGVAYVVQEPGDYEVS 1724
            ERAEAGVPAEFSIWTREAGAGGLAIAVEGPSKAEISFEDRKDGSCGVAYVVQEPGDYEVS
Sbjct: 2217 ERAEAGVPAEFSIWTREAGAGGLAIAVEGPSKAEISFEDRKDGSCGVAYVVQEPGDYEVS 2276

Query: 1725 VKFNEEHIPDSPFVVPVASPSGDARRLTVSSLQESGLKVNQPASFAVSLNGAKGAIDAKV 1904
            VKFNEEHIPDSPFVVPVASPSGDARRLTVSSLQESGLKVNQPASFAVSLNGAKGAIDAKV
Sbjct: 2277 VKFNEEHIPDSPFVVPVASPSGDARRLTVSSLQESGLKVNQPASFAVSLNGAKGAIDAKV 2336

Query: 1905 HSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGD 2084
            HSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGD
Sbjct: 2337 HSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGD 2396

Query: 2085 PGLVSAYGAGLEGGVTGSPAEFIVNTSNAGAGALSVTIDGPSKVKMDCQECPEGYRVTYT 2264
            PGLVSAYGAGLEGGVTGSPAEFIVNTSNAGAGALSVTIDGPSKVKMDCQECPEGYRVTYT
Sbjct: 2397 PGLVSAYGAGLEGGVTGSPAEFIVNTSNAGAGALSVTIDGPSKVKMDCQECPEGYRVTYT 2456

Query: 2265 PMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSVFVDSLTKTXXXXXXX 2444
            PMAPGSYLISIKYGGPYHIGGSPFKA+VTG RLVSNHSLHETSSVFVDSLTKT       
Sbjct: 2457 PMAPGSYLISIKYGGPYHIGGSPFKAKVTGPRLVSNHSLHETSSVFVDSLTKT-ASAPQH 2515

Query: 2445 XXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKAGNNMLLVGVHGPRTPCEEILVKH 2624
                     SKVLAKGLGLSKAYVGQK SFTVDCSKAGNNMLLVGVHGPRTPCEEILVKH
Sbjct: 2516 GALAGSTDASKVLAKGLGLSKAYVGQKSSFTVDCSKAGNNMLLVGVHGPRTPCEEILVKH 2575

Query: 2625 VGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLVP 2741
            VG+RLY+VSYLLKDKGEYTLVVKWGDEHIPGSPYRVLVP
Sbjct: 2576 VGNRLYNVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLVP 2614



 Score =  340 bits (872), Expect = 5e-93
 Identities = 275/859 (32%), Positives = 393/859 (45%), Gaps = 34/859 (3%)
 Frame = +3

Query: 258  ITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFYVDYVN-CGHVTAYGPGLSH- 431
            I  N + T TV+Y P  AG + + + + +   P SP++  V+  +    V A GPGLS  
Sbjct: 826  IIRNDNDTFTVKYTPRGAGSYTIMVLFADQATPTSPIRVKVEPSHDASKVKAEGPGLSRT 885

Query: 432  GV-VNKPAVFTVNTKDAGEGGLSLAIEGPSKAE----ISCTDNQDGTCSVSYLPVLPGDY 596
            GV + KP  FT+N K AG+G   +   G +K +    +   D+ D T +V Y PV  G  
Sbjct: 886  GVELGKPTHFTINAKAAGKGKPDVQFSGLAKGDAVRDVDIIDHHDNTYTVKYTPVQQGPV 945

Query: 597  SILVKYNEQHIPGSPFTARVTGDDSMRMSHLKV---GSAADIPINISETDLSL------- 746
             I V Y    IP SPF+  V+   S+ +S +KV   G   D+  +   T  S        
Sbjct: 946  GINVTYGGDPIPKSPFSVGVS--PSLDLSKIKVSGLGEKVDVGKDQEFTVKSKGAGGQGK 1003

Query: 747  LTATVVPPSGREEPCLLKR-LRNGHVGISFVPKETGEHLVHVKKNGQHVASSPIPVVISQ 923
            + + +  PSG   PC ++  L   +  + FVP+E G + V V  +G  V  SP PV    
Sbjct: 1004 VASKITGPSGTAVPCKVEPGLGADNSVVRFVPREEGPYEVEVTYDGVPVPGSPFPVEALP 1063

Query: 924  SEIGDASRVRVSGRGLHEGHTFEPAEFIIDTRDAGYGGLSLSIEGPSKVDINTEDLEDGT 1103
                  S+V+  G GL  G    PA F IDT+ AG GGL L++EGP +  +   D  DGT
Sbjct: 1064 PT--KPSKVKAFGPGLQGGSAGSPARFTIDTKGAGMGGLGLTVEGPCEAQLECLDNGDGT 1121

Query: 1104 CRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVT---GEGRVKESITRRQRAPSVANVGS 1274
            C V+Y PTEPG+Y INI FAD H+PGSPF   V       +VK S    +RA +      
Sbjct: 1122 CSVSYVPTEPGDYNINILFADTHIPGSPFKAHVVPCFDASKVKCSGPGLERATAGEAGQF 1181

Query: 1275 HCDLSLKIPEISIQDMTAQVTSPSGKSHEAEIVEGENHTYCIRFVPAEMGMHTVSVKYKG 1454
            H D S         ++T ++ S +G   E  I +  + T+ I ++P   G +TV++KY G
Sbjct: 1182 HVDCS----SAGSAELTIEIRSEAGLPAEVHIQDHGDGTHTITYIPLCPGAYTVTIKYGG 1237

Query: 1455 QHVPGSPFQFTVGPLGEGGAHKVRAGGPGLERAEAGVPA--EFSIWTR---EAGAGGLAI 1619
            Q VP  P +  V P  +     V+  GPG+E       A  EFS+  R   + G   +  
Sbjct: 1238 QPVPNFPSKLQVEPAVDTSG--VQCYGPGIEGQGVFREATTEFSVDARALTQTGGPHVKA 1295

Query: 1620 AVEGPSK--AEISFEDRKDGSCGVAYVVQEPGDYEVSVKFNEEHIPDSPFVVPVASPSGD 1793
             V  PS    E   +D  DG+  V Y   E G + V V ++   +P SPF VPV      
Sbjct: 1296 RVANPSGNLTETYVQDCGDGTYKVEYTPYEEGLHSVDVTYDGSPVPSSPFQVPVTEGCDP 1355

Query: 1794 ARRLTVSSLQESGLKVNQPASFAVSLNGA-KGAIDAKVHSPSGALEECYVTEIDQDKYAV 1970
            +R        +SG   N+P  F V   GA  G +   V  PS A   C   +      +V
Sbjct: 1356 SRVRVHGPGIQSGT-TNKPNKFTVETRGAGTGGLGLAVEGPSEAKMSCMDNK--DGSCSV 1412

Query: 1971 RFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPGLVSAYGAGLEGGVTGS--PA 2144
             +IP E G Y ++V + G  +PGSPFK+ V +     D   V   G GL  G+  +  P 
Sbjct: 1413 EYIPYEAGTYSLNVTYGGHQVPGSPFKVPVHDVT---DASKVKCSGPGLSPGMVRANLPQ 1469

Query: 2145 EFIVNTSNAGAGALSVTIDGPSKV--KMDCQECPEGYR-VTYTPMAPGSYLISIKYGGPY 2315
             F V+TS AG   L V + GP  +   +D  +  +G + V Y P   G Y IS+ YG   
Sbjct: 1470 SFQVDTSKAGVAPLQVKVQGPKGLVEPVDVVDNADGTQTVNYVPSREGPYSISVLYGEE- 1528

Query: 2316 HIGGSPFKARVTGHRLVSNHSLHETSSVFVDSLTKTXXXXXXXXXXXXXXXXSKVLAKGL 2495
             +  SPFK +V           H+ S V                         K    GL
Sbjct: 1529 EVPRSPFKVKVL--------PTHDASKV-------------------------KASGPGL 1555

Query: 2496 GLSKAYVGQKGSFTVDCSKAGNNMLLVGVHGPRTPCEEILVKHVGSRLYSVSYLLKDKGE 2675
              +         FT+D   AG  +L V +  P    ++  ++      Y+V+Y+    G 
Sbjct: 1556 NTTGVPASLPVEFTIDAKDAGEGLLAVQITDPEGKPKKTHIQDNHDGTYTVAYVPDVTGR 1615

Query: 2676 YTLVVKWGDEHIPGSPYRV 2732
            YT+++K+G + IP SPYRV
Sbjct: 1616 YTILIKYGGDEIPFSPYRV 1634



 Score =  322 bits (824), Expect = 2e-87
 Identities = 235/778 (30%), Positives = 366/778 (47%), Gaps = 43/778 (5%)
 Frame = +3

Query: 189  FTIK------KGEITGEVRMPSG-----KVAQPAITDNKDGTVTVRYAPSEAGLHEMDIR 335
            FT+K      +G++  ++  PSG     KV      DN      VR+ P E G +E+++ 
Sbjct: 991  FTVKSKGAGGQGKVASKITGPSGTAVPCKVEPGLGADNS----VVRFVPREEGPYEVEVT 1046

Query: 336  YDNMHIPGSPLQFY-VDYVNCGHVTAYGPGLSHGVVNKPAVFTVNTKDAGEGGLSLAIEG 512
            YD + +PGSP     +       V A+GPGL  G    PA FT++TK AG GGL L +EG
Sbjct: 1047 YDGVPVPGSPFPVEALPPTKPSKVKAFGPGLQGGSAGSPARFTIDTKGAGMGGLGLTVEG 1106

Query: 513  PSKAEISCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARVTG--DDSM---- 674
            P +A++ C DN DGTCSVSY+P  PGDY+I + + + HIPGSPF A V    D S     
Sbjct: 1107 PCEAQLECLDNGDGTCSVSYVPTEPGDYNINILFADTHIPGSPFKAHVVPCFDASKVKCS 1166

Query: 675  --RMSHLKVGSAADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKET 848
               +     G A    ++ S    + LT  +   +G      ++   +G   I+++P   
Sbjct: 1167 GPGLERATAGEAGQFHVDCSSAGSAELTIEIRSEAGLPAEVHIQDHGDGTHTITYIPLCP 1226

Query: 849  GEHLVHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEGHTFEPA--EFIIDTR- 1019
            G + V +K  GQ V + P  + +  +   D S V+  G G+     F  A  EF +D R 
Sbjct: 1227 GAYTVTIKYGGQPVPNFPSKLQVEPAV--DTSGVQCYGPGIEGQGVFREATTEFSVDARA 1284

Query: 1020 --DAGYGGLSLSIEGPS--KVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSP 1187
                G   +   +  PS    +   +D  DGT +V Y P E G + +++ +    VP SP
Sbjct: 1285 LTQTGGPHVKARVANPSGNLTETYVQDCGDGTYKVEYTPYEEGLHSVDVTYDGSPVPSSP 1344

Query: 1188 FSVKVTGEGRVKESITRRQRAPSVANVGSHCDLSLKIPEISIQDMTAQVTSPSGKSHEAE 1367
            F V VT EG     +                  +++        +   V  PS    +  
Sbjct: 1345 FQVPVT-EGCDPSRVRVHGPGIQSGTTNKPNKFTVETRGAGTGGLGLAVEGPS--EAKMS 1401

Query: 1368 IVEGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLE 1547
             ++ ++ +  + ++P E G ++++V Y G  VPGSPF+  V  + +  A KV+  GPGL 
Sbjct: 1402 CMDNKDGSCSVEYIPYEAGTYSLNVTYGGHQVPGSPFKVPVHDVTD--ASKVKCSGPGLS 1459

Query: 1548 --RAEAGVPAEFSIWTREAGAGGLAIAVEGPS--KAEISFEDRKDGSCGVAYVVQEPGDY 1715
                 A +P  F + T +AG   L + V+GP      +   D  DG+  V YV    G Y
Sbjct: 1460 PGMVRANLPQSFQVDTSKAGVAPLQVKVQGPKGLVEPVDVVDNADGTQTVNYVPSREGPY 1519

Query: 1716 EVSVKFNEEHIPDSPFVVPVASPSGDARRLTVS--SLQESGLKVNQPASFAVSLNGA-KG 1886
             +SV + EE +P SPF V V  P+ DA ++  S   L  +G+  + P  F +    A +G
Sbjct: 1520 SISVLYGEEEVPRSPFKVKVL-PTHDASKVKASGPGLNTTGVPASLPVEFTIDAKDAGEG 1578

Query: 1887 AIDAKVHSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGE 2066
             +  ++  P G  ++ ++ +     Y V ++P   G Y I +K+ G  IP SP+++R   
Sbjct: 1579 LLAVQITDPEGKPKKTHIQDNHDGTYTVAYVPDVTGRYTILIKYGGDEIPFSPYRVRAVP 1638

Query: 2067 PGHGGDPGL-VSAYGAGLEGGV-----TGSPAEFIVNTSNAGAGALSVTIDGP--SKVKM 2222
             G      + VS  G GL  G+      G      V+T  AG G ++ T+  P  S+V +
Sbjct: 1639 TGDASKCTVTVSIGGHGLGAGIGPTIQIGEETVITVDTKAAGKGKVTCTVCTPDGSEVDV 1698

Query: 2223 DCQECPEG-YRVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETS 2393
            D  E  +G + + YT   PG Y+I +++GG  H+  SPF+       L+  + L  TS
Sbjct: 1699 DVVENEDGTFDIFYTAPQPGKYVICVRFGGE-HVPNSPFQVTAPERPLMGVNGLDVTS 1755



 Score =  300 bits (769), Expect = 4e-81
 Identities = 252/895 (28%), Positives = 405/895 (45%), Gaps = 49/895 (5%)
 Frame = +3

Query: 201  KGEITGEVRMPSGKVAQPAITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFYV 380
            K  +  +V+   G      + DN +GT +  Y P +   H   + +  + IP SP +  V
Sbjct: 704  KAALRVQVQDNEGCPVDATVKDNGNGTYSCSYVPRKPVKHTAMVSWGGVSIPNSPFRVNV 763

Query: 381  DY-VNCGHVTAYGPGLSHGVV--NKPAVFTVNTKDAGEGGLSLAIE------GPSKAEIS 533
                +   V  YGPG++   +  ++P  FTV+  +AG+G +S+ I+      GP++A+I 
Sbjct: 764  GAGSHPNKVKVYGPGVAKTGLKAHEPTYFTVDCTEAGQGDVSIGIKCAPGVVGPTEADID 823

Query: 534  --CTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARVTGDDSMRMSHLKVGSAA 707
                 N + T +V Y P   G Y+I+V + +Q  P SP   +V        SH      A
Sbjct: 824  FDIIRNDNDTFTVKYTPRGAGSYTIMVLFADQATPTSPIRVKV------EPSHDASKVKA 877

Query: 708  DIPINISETDLSLLTATV----VPPSGREEPCL-LKRLRNGHV--------------GIS 830
            + P  +S T + L   T        +G+ +P +    L  G                 + 
Sbjct: 878  EGP-GLSRTGVELGKPTHFTINAKAAGKGKPDVQFSGLAKGDAVRDVDIIDHHDNTYTVK 936

Query: 831  FVPKETGEHLVHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEGHTFEPAEFII 1010
            + P + G   ++V   G  +  SP  V +S S   D S+++VSG G  +    +  EF +
Sbjct: 937  YTPVQQGPVGINVTYGGDPIPKSPFSVGVSPSL--DLSKIKVSGLG-EKVDVGKDQEFTV 993

Query: 1011 DTRDAG-YGGLSLSIEGPSKVDINTEDLEDG----TCRVTYCPTEPGNYIINIKFADQHV 1175
             ++ AG  G ++  I GPS   +  + +E G       V + P E G Y + + +    V
Sbjct: 994  KSKGAGGQGKVASKITGPSGTAVPCK-VEPGLGADNSVVRFVPREEGPYEVEVTYDGVPV 1052

Query: 1176 PGSPFSVKV---TGEGRVKESITRRQRAPSVANVGSHCDLSLKIPEISIQDMTAQVTSPS 1346
            PGSPF V+    T   +VK      Q      + GS    ++      +  +   V  P 
Sbjct: 1053 PGSPFPVEALPPTKPSKVKAFGPGLQGG----SAGSPARFTIDTKGAGMGGLGLTVEGPC 1108

Query: 1347 GKSHEAEIVEGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVR 1526
                + E ++  + T  + +VP E G + +++ +   H+PGSPF+  V P  +  A KV+
Sbjct: 1109 --EAQLECLDNGDGTCSVSYVPTEPGDYNINILFADTHIPGSPFKAHVVPCFD--ASKVK 1164

Query: 1527 AGGPGLERAEAGVPAEFSIWTREAGAGGLAIAV--EGPSKAEISFEDRKDGSCGVAYVVQ 1700
              GPGLERA AG   +F +    AG+  L I +  E    AE+  +D  DG+  + Y+  
Sbjct: 1165 CSGPGLERATAGEAGQFHVDCSSAGSAELTIEIRSEAGLPAEVHIQDHGDGTHTITYIPL 1224

Query: 1701 EPGDYEVSVKFNEEHIPDSPFVVPVASPSGDARRLTV--SSLQESGLKVNQPASFAVSLN 1874
             PG Y V++K+  + +P+ P  + V  P+ D   +      ++  G+       F+V   
Sbjct: 1225 CPGAYTVTIKYGGQPVPNFPSKLQV-EPAVDTSGVQCYGPGIEGQGVFREATTEFSVDAR 1283

Query: 1875 GAKGA----IDAKVHSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGS 2042
                     + A+V +PSG L E YV +     Y V + P E G++ +DV ++G+ +P S
Sbjct: 1284 ALTQTGGPHVKARVANPSGNLTETYVQDCGDGTYKVEYTPYEEGLHSVDVTYDGSPVPSS 1343

Query: 2043 PFKIRVGEPGHGGDPGLVSAYGAGLEGGVTGSPAEFIVNTSNAGAGALSVTIDGPSKVKM 2222
            PF++ V E   G DP  V  +G G++ G T  P +F V T  AG G L + ++GPS+ KM
Sbjct: 1344 PFQVPVTE---GCDPSRVRVHGPGIQSGTTNKPNKFTVETRGAGTGGLGLAVEGPSEAKM 1400

Query: 2223 DCQECPEGY-RVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSV 2399
             C +  +G   V Y P   G+Y +++ YGG + + GSPFK  V           H+ +  
Sbjct: 1401 SCMDNKDGSCSVEYIPYEAGTYSLNVTYGG-HQVPGSPFKVPV-----------HDVTDA 1448

Query: 2400 FVDSLTKTXXXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQK--GSFTVDCSKAGNNMLL 2573
                                    SKV   G GLS   V      SF VD SKAG   L 
Sbjct: 1449 ------------------------SKVKCSGPGLSPGMVRANLPQSFQVDTSKAGVAPLQ 1484

Query: 2574 VGVHGPRTPCEEILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLV 2738
            V V GP+   E + V        +V+Y+   +G Y++ V +G+E +P SP++V V
Sbjct: 1485 VKVQGPKGLVEPVDVVDNADGTQTVNYVPSREGPYSISVLYGEEEVPRSPFKVKV 1539



 Score =  286 bits (733), Expect = 6e-77
 Identities = 248/893 (27%), Positives = 386/893 (43%), Gaps = 47/893 (5%)
 Frame = +3

Query: 201  KGEITGEVRMPSGKVAQPAITDNKDG--TVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQF 374
            +GE+   V  P+G   +  +T N D   T +V Y P   G H++ + +   HI  SP + 
Sbjct: 313  QGEVLVYVEDPAGHQEEAKVTANNDKNRTFSVWYVPEVTGTHKVTVLFAGQHIAKSPFEV 372

Query: 375  YVD--YVNCGHVTAYGPGL--SHGVVNKPAVFTVNTKDAGEGGLSLAIEGPS----KAEI 530
            YVD    +   VTA GPGL  S  + NK   F + T  AG G + + I+ P+      E 
Sbjct: 373  YVDKSQGDASKVTAQGPGLEPSGNIANKTTYFEIFTAGAGTGEVEVVIQDPTGQKGTVEP 432

Query: 531  SCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARV----------TGDDSMRM 680
                  D T   SY P + G +++ V +    IP SP+T  V               ++ 
Sbjct: 433  QLEARGDSTYRCSYQPTMEGVHTVHVTFAGVPIPRSPYTVTVGQACNPGACRAVGRGLQP 492

Query: 681  SHLKVGSAADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHL 860
              ++V   AD  +         L  TV  P G EE    K L +G  G  + P   G + 
Sbjct: 493  KGVRVKETADFKVYTKGAGSGDLKVTVKGPKG-EERVKQKDLGDGVYGFEYYPMVPGTYT 551

Query: 861  VHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEGHTFEPAEFIIDTRDAGYGGL 1040
            V +   GQ++  SP  V +  +E G+  +VR  G GL  G   + A+F+++      G L
Sbjct: 552  VTITWGGQNIGRSPFEVKVG-TECGN-QKVRAWGPGLEGGVVGKSADFVVEAIGDDVGTL 609

Query: 1041 SLSIEGPSKVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTGEGRV 1220
              S+EGPS+  I  +D  DG+C V Y P E G Y +++    + +  SPF   +    + 
Sbjct: 610  GFSVEGPSQAKIECDDKGDGSCDVRYWPQEAGEYAVHVLCNSEDIRLSPFMADIREAPQD 669

Query: 1221 KESITRRQRAPSVANVG----SHCDLSLKIPEISIQDMTAQVTSPSGKSHEAEIVEGENH 1388
                  + R P +   G       + ++         +  QV    G   +A + +  N 
Sbjct: 670  FHPDRVKARGPGLEKTGVAVNKPAEFTVDAKHGGKAALRVQVQDNEGCPVDATVKDNGNG 729

Query: 1389 TYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAH--KVRAGGPGLERA--E 1556
            TY   +VP +   HT  V + G  +P SPF+  VG     G+H  KV+  GPG+ +   +
Sbjct: 730  TYSCSYVPRKPVKHTAMVSWGGVSIPNSPFRVNVG----AGSHPNKVKVYGPGVAKTGLK 785

Query: 1557 AGVPAEFSIWTREAGAGGLAIAVE------GPSKAEISFE--DRKDGSCGVAYVVQEPGD 1712
            A  P  F++   EAG G ++I ++      GP++A+I F+     + +  V Y  +  G 
Sbjct: 786  AHEPTYFTVDCTEAGQGDVSIGIKCAPGVVGPTEADIDFDIIRNDNDTFTVKYTPRGAGS 845

Query: 1713 YEVSVKFNEEHIPDSPFVVPVASPSGDARRLTVS--SLQESGLKVNQPASFAVSLNGA-K 1883
            Y + V F ++  P SP  V V  PS DA ++      L  +G+++ +P  F ++   A K
Sbjct: 846  YTIMVLFADQATPTSPIRVKV-EPSHDASKVKAEGPGLSRTGVELGKPTHFTINAKAAGK 904

Query: 1884 GAIDAKVH--SPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIR 2057
            G  D +    +   A+ +  + +   + Y V++ P + G   I+V + G  IP SPF + 
Sbjct: 905  GKPDVQFSGLAKGDAVRDVDIIDHHDNTYTVKYTPVQQGPVGINVTYGGDPIPKSPFSVG 964

Query: 2058 VGEPGHGGDPGLVSAYGAGLEGGVTGSPAEFIVNTSNAGA-GALSVTIDGPSKVKMDCQE 2234
            V       D   +   G G +  V G   EF V +  AG  G ++  I GPS   + C+ 
Sbjct: 965  VSP---SLDLSKIKVSGLGEKVDV-GKDQEFTVKSKGAGGQGKVASKITGPSGTAVPCKV 1020

Query: 2235 CP----EGYRVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSVF 2402
             P    +   V + P   G Y + + Y G   + GSPF                      
Sbjct: 1021 EPGLGADNSVVRFVPREEGPYEVEVTYDG-VPVPGSPFP--------------------- 1058

Query: 2403 VDSLTKTXXXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKAGNNMLLVGV 2582
            V++L  T                SKV A G GL     G    FT+D   AG   L + V
Sbjct: 1059 VEALPPT--------------KPSKVKAFGPGLQGGSAGSPARFTIDTKGAGMGGLGLTV 1104

Query: 2583 HGPRTPCE-EILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLV 2738
             G   PCE ++     G    SVSY+  + G+Y + + + D HIPGSP++  V
Sbjct: 1105 EG---PCEAQLECLDNGDGTCSVSYVPTEPGDYNINILFADTHIPGSPFKAHV 1154



 Score =  273 bits (699), Expect = 6e-73
 Identities = 241/887 (27%), Positives = 384/887 (43%), Gaps = 42/887 (4%)
 Frame = +3

Query: 204  GEITGEVRMPSGKVAQPAITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFYVD 383
            G++   V+ P G+  +    D  DG     Y P   G + + I +   +I  SP +  V 
Sbjct: 513  GDLKVTVKGPKGE-ERVKQKDLGDGVYGFEYYPMVPGTYTVTITWGGQNIGRSPFEVKVG 571

Query: 384  YVNCGH--VTAYGPGLSHGVVNKPAVFTVNTKDAGEGGLSLAIEGPSKAEISCTDNQDGT 557
               CG+  V A+GPGL  GVV K A F V       G L  ++EGPS+A+I C D  DG+
Sbjct: 572  -TECGNQKVRAWGPGLEGGVVGKSADFVVEAIGDDVGTLGFSVEGPSQAKIECDDKGDGS 630

Query: 558  CSVSYLPVLPGDYSILVKYNEQHIPGSPFTARV-------------TGDDSMRMSHLKVG 698
            C V Y P   G+Y++ V  N + I  SPF A +                  +  + + V 
Sbjct: 631  CDVRYWPQEAGEYAVHVLCNSEDIRLSPFMADIREAPQDFHPDRVKARGPGLEKTGVAVN 690

Query: 699  SAADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKN 878
              A+  ++      + L   V    G      +K   NG    S+VP++  +H   V   
Sbjct: 691  KPAEFTVDAKHGGKAALRVQVQDNEGCPVDATVKDNGNGTYSCSYVPRKPVKHTAMVSWG 750

Query: 879  GQHVASSPIPVVISQSEIGDASRVRVSGRGLHEG--HTFEPAEFIIDTRDAGYGGLSLSI 1052
            G  + +SP  V +        ++V+V G G+ +      EP  F +D  +AG G +S+ I
Sbjct: 751  GVSIPNSPFRVNVGAG--SHPNKVKVYGPGVAKTGLKAHEPTYFTVDCTEAGQGDVSIGI 808

Query: 1053 E------GPSKVDINTEDL--EDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVT- 1205
            +      GP++ DI+ + +  ++ T  V Y P   G+Y I + FADQ  P SP  VKV  
Sbjct: 809  KCAPGVVGPTEADIDFDIIRNDNDTFTVKYTPRGAGSYTIMVLFADQATPTSPIRVKVEP 868

Query: 1206 --GEGRVKESITRRQRAPSVANVGSHCDLSLKIPEISIQDMTAQVTSPSGKSHEAEIVEG 1379
                 +VK       R        +H  ++ K       D+     +      + +I++ 
Sbjct: 869  SHDASKVKAEGPGLSRTGVELGKPTHFTINAKAAGKGKPDVQFSGLAKGDAVRDVDIIDH 928

Query: 1380 ENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLERAEA 1559
             ++TY +++ P + G   ++V Y G  +P SPF   V P  +    K++  G G E+ + 
Sbjct: 929  HDNTYTVKYTPVQQGPVGINVTYGGDPIPKSPFSVGVSPSLD--LSKIKVSGLG-EKVDV 985

Query: 1560 GVPAEFSIWTREAGA-GGLAIAVEGPSKAEISFEDR----KDGSCGVAYVVQEPGDYEVS 1724
            G   EF++ ++ AG  G +A  + GPS   +  +       D S  V +V +E G YEV 
Sbjct: 986  GKDQEFTVKSKGAGGQGKVASKITGPSGTAVPCKVEPGLGADNSV-VRFVPREEGPYEVE 1044

Query: 1725 VKFNEEHIPDSPFVVPVASPSGDARRLTVSSLQESGLKVNQPASFAVSLNGA-KGAIDAK 1901
            V ++   +P SPF V    P+  ++        + G     PA F +   GA  G +   
Sbjct: 1045 VTYDGVPVPGSPFPVEALPPTKPSKVKAFGPGLQGG-SAGSPARFTIDTKGAGMGGLGLT 1103

Query: 1902 VHSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGG 2081
            V  P  A  EC   +      +V ++P E G Y I++ F  THIPGSPFK  V       
Sbjct: 1104 VEGPCEAQLEC--LDNGDGTCSVSYVPTEPGDYNINILFADTHIPGSPFKAHVVP---CF 1158

Query: 2082 DPGLVSAYGAGLEGGVTGSPAEFIVNTSNAGAGALSVTI--DGPSKVKMDCQECPEG-YR 2252
            D   V   G GLE    G   +F V+ S+AG+  L++ I  +     ++  Q+  +G + 
Sbjct: 1159 DASKVKCSGPGLERATAGEAGQFHVDCSSAGSAELTIEIRSEAGLPAEVHIQDHGDGTHT 1218

Query: 2253 VTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSVFVDSLTKTXXX 2432
            +TY P+ PG+Y ++IKYGG   +   P K +V                  VD+       
Sbjct: 1219 ITYIPLCPGAYTVTIKYGG-QPVPNFPSKLQV---------------EPAVDT------- 1255

Query: 2433 XXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGS--FTVDC---SKAGNNMLLVGVHGPRT 2597
                         S V   G G+    V ++ +  F+VD    ++ G   +   V  P  
Sbjct: 1256 -------------SGVQCYGPGIEGQGVFREATTEFSVDARALTQTGGPHVKARVANPSG 1302

Query: 2598 PCEEILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLV 2738
               E  V+  G   Y V Y   ++G +++ V +    +P SP++V V
Sbjct: 1303 NLTETYVQDCGDGTYKVEYTPYEEGLHSVDVTYDGSPVPSSPFQVPV 1349



 Score =  226 bits (577), Expect = 8e-59
 Identities = 230/843 (27%), Positives = 366/843 (43%), Gaps = 50/843 (5%)
 Frame = +3

Query: 354  PGSPLQFYVDYVNCGHVTAYGPGL--SHGVVNKPAVFTVNTKDAGEGGLSLAIEGPS--- 518
            PG+PL+     +N     AYGPG+  +  +V K A FTV T+ AG+G + + +E P+   
Sbjct: 271  PGAPLR---PKLNPKKARAYGPGIEPTGNMVKKRAEFTVETRSAGQGEVLVYVEDPAGHQ 327

Query: 519  -KAEISCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARV--TGDDSMRMSHL 689
             +A+++  ++++ T SV Y+P + G + + V +  QHI  SPF   V  +  D+ +++  
Sbjct: 328  EEAKVTANNDKNRTFSVWYVPEVTGTHKVTVLFAGQHIAKSPFEVYVDKSQGDASKVTAQ 387

Query: 690  KVGSAADIPINISETDLSLLTA---------TVVPPSGRE---EPCLLKRLRNGHVGISF 833
              G      I    T   + TA          +  P+G++   EP L  R  +     S+
Sbjct: 388  GPGLEPSGNIANKTTYFEIFTAGAGTGEVEVVIQDPTGQKGTVEPQLEAR-GDSTYRCSY 446

Query: 834  VPKETGEHLVHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEG--HTFEPAEFI 1007
             P   G H VHV   G  +  SP  V + Q+   +    R  GRGL        E A+F 
Sbjct: 447  QPTMEGVHTVHVTFAGVPIPRSPYTVTVGQA--CNPGACRAVGRGLQPKGVRVKETADFK 504

Query: 1008 IDTRDAGYGGLSLSIEGPSKVD-INTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGS 1184
            + T+ AG G L ++++GP   + +  +DL DG     Y P  PG Y + I +  Q++  S
Sbjct: 505  VYTKGAGSGDLKVTVKGPKGEERVKQKDLGDGVYGFEYYPMVPGTYTVTITWGGQNIGRS 564

Query: 1185 PFSVKVTGE-GRVKESITRRQRAPSVAN--VGSHCDLSLKIPEISIQDMTAQVTSPSGKS 1355
            PF VKV  E G  K     R   P +    VG   D  ++     +  +   V  PS   
Sbjct: 565  PFEVKVGTECGNQKV----RAWGPGLEGGVVGKSADFVVEAIGDDVGTLGFSVEGPSQAK 620

Query: 1356 HEAEIVEGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEG-GAHKVRAG 1532
             E +  +  + +  +R+ P E G + V V    + +  SPF   +    +     +V+A 
Sbjct: 621  IECD--DKGDGSCDVRYWPQEAGEYAVHVLCNSEDIRLSPFMADIREAPQDFHPDRVKAR 678

Query: 1533 GPGLERAEAGV--PAEFSIWTREAGAGGLAIAVEGPS--KAEISFEDRKDGSCGVAYVVQ 1700
            GPGLE+    V  PAEF++  +  G   L + V+       + + +D  +G+   +YV +
Sbjct: 679  GPGLEKTGVAVNKPAEFTVDAKHGGKAALRVQVQDNEGCPVDATVKDNGNGTYSCSYVPR 738

Query: 1701 EPGDYEVSVKFNEEHIPDSPFVVPVASPSGDAR-RLTVSSLQESGLKVNQPASFAVSLNG 1877
            +P  +   V +    IP+SPF V V + S   + ++    + ++GLK ++P  F V    
Sbjct: 739  KPVKHTAMVSWGGVSIPNSPFRVNVGAGSHPNKVKVYGPGVAKTGLKAHEPTYFTVDCTE 798

Query: 1878 A-KGAIDAKVH------SPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIP 2036
            A +G +   +        P+ A  +  +   D D + V++ PR  G Y I V F     P
Sbjct: 799  AGQGDVSIGIKCAPGVVGPTEADIDFDIIRNDNDTFTVKYTPRGAGSYTIMVLFADQATP 858

Query: 2037 GSPFKIRVGEPGHGGDPGLVSAYGAGLE--GGVTGSPAEFIVNTSNAGAGALSVTIDGPS 2210
             SP +++V EP H  D   V A G GL   G   G P  F +N   AG G   V   G +
Sbjct: 859  TSPIRVKV-EPSH--DASKVKAEGPGLSRTGVELGKPTHFTINAKAAGKGKPDVQFSGLA 915

Query: 2211 K----VKMDCQECPEG-YRVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNH 2375
            K      +D  +  +  Y V YTP+  G   I++ YGG   I  SPF   V+        
Sbjct: 916  KGDAVRDVDIIDHHDNTYTVKYTPVQQGPVGINVTYGGD-PIPKSPFSVGVS-------- 966

Query: 2376 SLHETSSVFVDSLTKTXXXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKA 2555
                                            SK+   GLG  K  VG+   FTV    A
Sbjct: 967  ---------------------------PSLDLSKIKVSGLG-EKVDVGKDQEFTVKSKGA 998

Query: 2556 GNN----MLLVGVHGPRTPCEEILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSP 2723
            G        + G  G   PC+  +   +G+    V ++ +++G Y + V +    +PGSP
Sbjct: 999  GGQGKVASKITGPSGTAVPCK--VEPGLGADNSVVRFVPREEGPYEVEVTYDGVPVPGSP 1056

Query: 2724 YRV 2732
            + V
Sbjct: 1057 FPV 1059


>ref|XP_867555.1| PREDICTED: similar to Filamin A (Alpha-filamin) (Filamin 1)
            (Endothelial actin-binding protein) (Actin-binding
            protein 280) (ABP-280) (Nonmuscle filamin) isoform 10
            [Canis familiaris].
          Length = 2606

 Score = 1715 bits (4441), Expect = 0.0
 Identities = 850/879 (96%), Positives = 859/879 (97%)
 Frame = +3

Query: 105  QTWAPERPLVGVNGLDVTSLRPFDLVIPFTIKKGEITGEVRMPSGKVAQPAITDNKDGTV 284
            Q  APERPL+GVNGLDVTSLRPFDLVIPFTIKKGEITGEVRMPSGKVAQPAITDNKDGTV
Sbjct: 1729 QVTAPERPLMGVNGLDVTSLRPFDLVIPFTIKKGEITGEVRMPSGKVAQPAITDNKDGTV 1788

Query: 285  TVRYAPSEAGLHEMDIRYDNMHIPGSPLQFYVDYVNCGHVTAYGPGLSHGVVNKPAVFTV 464
            TVRYAPSEAGLHEMDIRYDNMHIPGSPLQFYVDYVNCGHVTAYGPGL+HGVVNKPAVFTV
Sbjct: 1789 TVRYAPSEAGLHEMDIRYDNMHIPGSPLQFYVDYVNCGHVTAYGPGLTHGVVNKPAVFTV 1848

Query: 465  NTKDAGEGGLSLAIEGPSKAEISCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPF 644
            NTKDAGEGGLSLAIEGPSKAEISCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPF
Sbjct: 1849 NTKDAGEGGLSLAIEGPSKAEISCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPF 1908

Query: 645  TARVTGDDSMRMSHLKVGSAADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVG 824
            TARVTGDDSMRMSHLKVGSAADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVG
Sbjct: 1909 TARVTGDDSMRMSHLKVGSAADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVG 1968

Query: 825  ISFVPKETGEHLVHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEGHTFEPAEF 1004
            ISFVPKETGEHLVHVKKNGQHVASSPIPVVISQSEIGDASRVRVSG+GLHEGHTFEPAEF
Sbjct: 1969 ISFVPKETGEHLVHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGQGLHEGHTFEPAEF 2028

Query: 1005 IIDTRDAGYGGLSLSIEGPSKVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGS 1184
            IIDTRDAGYGGLSLSIEGPSKVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGS
Sbjct: 2029 IIDTRDAGYGGLSLSIEGPSKVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGS 2088

Query: 1185 PFSVKVTGEGRVKESITRRQRAPSVANVGSHCDLSLKIPEISIQDMTAQVTSPSGKSHEA 1364
            PFSVKVTGEGRVKESITRR+RAPSVANVGSHC+LSLKIPEISIQDMTAQVTSPSGK+HEA
Sbjct: 2089 PFSVKVTGEGRVKESITRRRRAPSVANVGSHCNLSLKIPEISIQDMTAQVTSPSGKTHEA 2148

Query: 1365 EIVEGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGL 1544
            EIVEGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGL
Sbjct: 2149 EIVEGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGL 2208

Query: 1545 ERAEAGVPAEFSIWTREAGAGGLAIAVEGPSKAEISFEDRKDGSCGVAYVVQEPGDYEVS 1724
            ERAEAGVPAEFSIWTREAGAGGLAIAVEGPSKAEISFEDRKDGSCGVAYVVQEPGDYEVS
Sbjct: 2209 ERAEAGVPAEFSIWTREAGAGGLAIAVEGPSKAEISFEDRKDGSCGVAYVVQEPGDYEVS 2268

Query: 1725 VKFNEEHIPDSPFVVPVASPSGDARRLTVSSLQESGLKVNQPASFAVSLNGAKGAIDAKV 1904
            VKFNEEHIPDSPFVVPVASPSGDARRLTVSSLQESGLKVNQPASFAVSLNGAKGAIDAKV
Sbjct: 2269 VKFNEEHIPDSPFVVPVASPSGDARRLTVSSLQESGLKVNQPASFAVSLNGAKGAIDAKV 2328

Query: 1905 HSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGD 2084
            HSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGD
Sbjct: 2329 HSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGD 2388

Query: 2085 PGLVSAYGAGLEGGVTGSPAEFIVNTSNAGAGALSVTIDGPSKVKMDCQECPEGYRVTYT 2264
            PGLVSAYGAGLEGGVTGSPAEFIVNTSNAGAGALSVTIDGPSKVKMDCQECPEGYRVTYT
Sbjct: 2389 PGLVSAYGAGLEGGVTGSPAEFIVNTSNAGAGALSVTIDGPSKVKMDCQECPEGYRVTYT 2448

Query: 2265 PMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSVFVDSLTKTXXXXXXX 2444
            PMAPGSYLISIKYGGPYHIGGSPFKA+VTG RLVSNHSLHETSSVFVDSLTKT       
Sbjct: 2449 PMAPGSYLISIKYGGPYHIGGSPFKAKVTGPRLVSNHSLHETSSVFVDSLTKT-ASAPQH 2507

Query: 2445 XXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKAGNNMLLVGVHGPRTPCEEILVKH 2624
                     SKVLAKGLGLSKAYVGQK SFTVDCSKAGNNMLLVGVHGPRTPCEEILVKH
Sbjct: 2508 GALAGSTDASKVLAKGLGLSKAYVGQKSSFTVDCSKAGNNMLLVGVHGPRTPCEEILVKH 2567

Query: 2625 VGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLVP 2741
            VG+RLY+VSYLLKDKGEYTLVVKWGDEHIPGSPYRVLVP
Sbjct: 2568 VGNRLYNVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLVP 2606



 Score =  340 bits (872), Expect = 5e-93
 Identities = 275/859 (32%), Positives = 393/859 (45%), Gaps = 34/859 (3%)
 Frame = +3

Query: 258  ITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFYVDYVN-CGHVTAYGPGLSH- 431
            I  N + T TV+Y P  AG + + + + +   P SP++  V+  +    V A GPGLS  
Sbjct: 826  IIRNDNDTFTVKYTPRGAGSYTIMVLFADQATPTSPIRVKVEPSHDASKVKAEGPGLSRT 885

Query: 432  GV-VNKPAVFTVNTKDAGEGGLSLAIEGPSKAE----ISCTDNQDGTCSVSYLPVLPGDY 596
            GV + KP  FT+N K AG+G   +   G +K +    +   D+ D T +V Y PV  G  
Sbjct: 886  GVELGKPTHFTINAKAAGKGKPDVQFSGLAKGDAVRDVDIIDHHDNTYTVKYTPVQQGPV 945

Query: 597  SILVKYNEQHIPGSPFTARVTGDDSMRMSHLKV---GSAADIPINISETDLSL------- 746
             I V Y    IP SPF+  V+   S+ +S +KV   G   D+  +   T  S        
Sbjct: 946  GINVTYGGDPIPKSPFSVGVS--PSLDLSKIKVSGLGEKVDVGKDQEFTVKSKGAGGQGK 1003

Query: 747  LTATVVPPSGREEPCLLKR-LRNGHVGISFVPKETGEHLVHVKKNGQHVASSPIPVVISQ 923
            + + +  PSG   PC ++  L   +  + FVP+E G + V V  +G  V  SP PV    
Sbjct: 1004 VASKITGPSGTAVPCKVEPGLGADNSVVRFVPREEGPYEVEVTYDGVPVPGSPFPVEALP 1063

Query: 924  SEIGDASRVRVSGRGLHEGHTFEPAEFIIDTRDAGYGGLSLSIEGPSKVDINTEDLEDGT 1103
                  S+V+  G GL  G    PA F IDT+ AG GGL L++EGP +  +   D  DGT
Sbjct: 1064 PT--KPSKVKAFGPGLQGGSAGSPARFTIDTKGAGMGGLGLTVEGPCEAQLECLDNGDGT 1121

Query: 1104 CRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVT---GEGRVKESITRRQRAPSVANVGS 1274
            C V+Y PTEPG+Y INI FAD H+PGSPF   V       +VK S    +RA +      
Sbjct: 1122 CSVSYVPTEPGDYNINILFADTHIPGSPFKAHVVPCFDASKVKCSGPGLERATAGEAGQF 1181

Query: 1275 HCDLSLKIPEISIQDMTAQVTSPSGKSHEAEIVEGENHTYCIRFVPAEMGMHTVSVKYKG 1454
            H D S         ++T ++ S +G   E  I +  + T+ I ++P   G +TV++KY G
Sbjct: 1182 HVDCS----SAGSAELTIEIRSEAGLPAEVHIQDHGDGTHTITYIPLCPGAYTVTIKYGG 1237

Query: 1455 QHVPGSPFQFTVGPLGEGGAHKVRAGGPGLERAEAGVPA--EFSIWTR---EAGAGGLAI 1619
            Q VP  P +  V P  +     V+  GPG+E       A  EFS+  R   + G   +  
Sbjct: 1238 QPVPNFPSKLQVEPAVDTSG--VQCYGPGIEGQGVFREATTEFSVDARALTQTGGPHVKA 1295

Query: 1620 AVEGPSK--AEISFEDRKDGSCGVAYVVQEPGDYEVSVKFNEEHIPDSPFVVPVASPSGD 1793
             V  PS    E   +D  DG+  V Y   E G + V V ++   +P SPF VPV      
Sbjct: 1296 RVANPSGNLTETYVQDCGDGTYKVEYTPYEEGLHSVDVTYDGSPVPSSPFQVPVTEGCDP 1355

Query: 1794 ARRLTVSSLQESGLKVNQPASFAVSLNGA-KGAIDAKVHSPSGALEECYVTEIDQDKYAV 1970
            +R        +SG   N+P  F V   GA  G +   V  PS A   C   +      +V
Sbjct: 1356 SRVRVHGPGIQSGT-TNKPNKFTVETRGAGTGGLGLAVEGPSEAKMSCMDNK--DGSCSV 1412

Query: 1971 RFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPGLVSAYGAGLEGGVTGS--PA 2144
             +IP E G Y ++V + G  +PGSPFK+ V +     D   V   G GL  G+  +  P 
Sbjct: 1413 EYIPYEAGTYSLNVTYGGHQVPGSPFKVPVHDVT---DASKVKCSGPGLSPGMVRANLPQ 1469

Query: 2145 EFIVNTSNAGAGALSVTIDGPSKV--KMDCQECPEGYR-VTYTPMAPGSYLISIKYGGPY 2315
             F V+TS AG   L V + GP  +   +D  +  +G + V Y P   G Y IS+ YG   
Sbjct: 1470 SFQVDTSKAGVAPLQVKVQGPKGLVEPVDVVDNADGTQTVNYVPSREGPYSISVLYGEE- 1528

Query: 2316 HIGGSPFKARVTGHRLVSNHSLHETSSVFVDSLTKTXXXXXXXXXXXXXXXXSKVLAKGL 2495
             +  SPFK +V           H+ S V                         K    GL
Sbjct: 1529 EVPRSPFKVKVL--------PTHDASKV-------------------------KASGPGL 1555

Query: 2496 GLSKAYVGQKGSFTVDCSKAGNNMLLVGVHGPRTPCEEILVKHVGSRLYSVSYLLKDKGE 2675
              +         FT+D   AG  +L V +  P    ++  ++      Y+V+Y+    G 
Sbjct: 1556 NTTGVPASLPVEFTIDAKDAGEGLLAVQITDPEGKPKKTHIQDNHDGTYTVAYVPDVTGR 1615

Query: 2676 YTLVVKWGDEHIPGSPYRV 2732
            YT+++K+G + IP SPYRV
Sbjct: 1616 YTILIKYGGDEIPFSPYRV 1634



 Score =  321 bits (823), Expect = 2e-87
 Identities = 233/773 (30%), Positives = 365/773 (47%), Gaps = 38/773 (4%)
 Frame = +3

Query: 189  FTIK------KGEITGEVRMPSG-----KVAQPAITDNKDGTVTVRYAPSEAGLHEMDIR 335
            FT+K      +G++  ++  PSG     KV      DN      VR+ P E G +E+++ 
Sbjct: 991  FTVKSKGAGGQGKVASKITGPSGTAVPCKVEPGLGADNS----VVRFVPREEGPYEVEVT 1046

Query: 336  YDNMHIPGSPLQFY-VDYVNCGHVTAYGPGLSHGVVNKPAVFTVNTKDAGEGGLSLAIEG 512
            YD + +PGSP     +       V A+GPGL  G    PA FT++TK AG GGL L +EG
Sbjct: 1047 YDGVPVPGSPFPVEALPPTKPSKVKAFGPGLQGGSAGSPARFTIDTKGAGMGGLGLTVEG 1106

Query: 513  PSKAEISCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARVTG--DDSM---- 674
            P +A++ C DN DGTCSVSY+P  PGDY+I + + + HIPGSPF A V    D S     
Sbjct: 1107 PCEAQLECLDNGDGTCSVSYVPTEPGDYNINILFADTHIPGSPFKAHVVPCFDASKVKCS 1166

Query: 675  --RMSHLKVGSAADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKET 848
               +     G A    ++ S    + LT  +   +G      ++   +G   I+++P   
Sbjct: 1167 GPGLERATAGEAGQFHVDCSSAGSAELTIEIRSEAGLPAEVHIQDHGDGTHTITYIPLCP 1226

Query: 849  GEHLVHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEGHTFEPA--EFIIDTR- 1019
            G + V +K  GQ V + P  + +  +   D S V+  G G+     F  A  EF +D R 
Sbjct: 1227 GAYTVTIKYGGQPVPNFPSKLQVEPAV--DTSGVQCYGPGIEGQGVFREATTEFSVDARA 1284

Query: 1020 --DAGYGGLSLSIEGPS--KVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSP 1187
                G   +   +  PS    +   +D  DGT +V Y P E G + +++ +    VP SP
Sbjct: 1285 LTQTGGPHVKARVANPSGNLTETYVQDCGDGTYKVEYTPYEEGLHSVDVTYDGSPVPSSP 1344

Query: 1188 FSVKVTGEGRVKESITRRQRAPSVANVGSHCDLSLKIPEISIQDMTAQVTSPSGKSHEAE 1367
            F V VT EG     +                  +++        +   V  PS    +  
Sbjct: 1345 FQVPVT-EGCDPSRVRVHGPGIQSGTTNKPNKFTVETRGAGTGGLGLAVEGPS--EAKMS 1401

Query: 1368 IVEGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLE 1547
             ++ ++ +  + ++P E G ++++V Y G  VPGSPF+  V  + +  A KV+  GPGL 
Sbjct: 1402 CMDNKDGSCSVEYIPYEAGTYSLNVTYGGHQVPGSPFKVPVHDVTD--ASKVKCSGPGLS 1459

Query: 1548 --RAEAGVPAEFSIWTREAGAGGLAIAVEGPS--KAEISFEDRKDGSCGVAYVVQEPGDY 1715
                 A +P  F + T +AG   L + V+GP      +   D  DG+  V YV    G Y
Sbjct: 1460 PGMVRANLPQSFQVDTSKAGVAPLQVKVQGPKGLVEPVDVVDNADGTQTVNYVPSREGPY 1519

Query: 1716 EVSVKFNEEHIPDSPFVVPVASPSGDARRLTVS--SLQESGLKVNQPASFAVSLNGA-KG 1886
             +SV + EE +P SPF V V  P+ DA ++  S   L  +G+  + P  F +    A +G
Sbjct: 1520 SISVLYGEEEVPRSPFKVKVL-PTHDASKVKASGPGLNTTGVPASLPVEFTIDAKDAGEG 1578

Query: 1887 AIDAKVHSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGE 2066
             +  ++  P G  ++ ++ +     Y V ++P   G Y I +K+ G  IP SP+++R   
Sbjct: 1579 LLAVQITDPEGKPKKTHIQDNHDGTYTVAYVPDVTGRYTILIKYGGDEIPFSPYRVRAVP 1638

Query: 2067 PGHGGDPGLVSAYGAGLEGGV-TGSPAEFIVNTSNAGAGALSVTIDGP--SKVKMDCQEC 2237
                GD    +  GAG+   +  G      V+T  AG G ++ T+  P  S+V +D  E 
Sbjct: 1639 T---GDASKCTVTGAGIGPTIQIGEETVITVDTKAAGKGKVTCTVCTPDGSEVDVDVVEN 1695

Query: 2238 PEG-YRVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETS 2393
             +G + + YT   PG Y+I +++GG  H+  SPF+       L+  + L  TS
Sbjct: 1696 EDGTFDIFYTAPQPGKYVICVRFGGE-HVPNSPFQVTAPERPLMGVNGLDVTS 1747



 Score =  300 bits (769), Expect = 4e-81
 Identities = 252/895 (28%), Positives = 405/895 (45%), Gaps = 49/895 (5%)
 Frame = +3

Query: 201  KGEITGEVRMPSGKVAQPAITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFYV 380
            K  +  +V+   G      + DN +GT +  Y P +   H   + +  + IP SP +  V
Sbjct: 704  KAALRVQVQDNEGCPVDATVKDNGNGTYSCSYVPRKPVKHTAMVSWGGVSIPNSPFRVNV 763

Query: 381  DY-VNCGHVTAYGPGLSHGVV--NKPAVFTVNTKDAGEGGLSLAIE------GPSKAEIS 533
                +   V  YGPG++   +  ++P  FTV+  +AG+G +S+ I+      GP++A+I 
Sbjct: 764  GAGSHPNKVKVYGPGVAKTGLKAHEPTYFTVDCTEAGQGDVSIGIKCAPGVVGPTEADID 823

Query: 534  --CTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARVTGDDSMRMSHLKVGSAA 707
                 N + T +V Y P   G Y+I+V + +Q  P SP   +V        SH      A
Sbjct: 824  FDIIRNDNDTFTVKYTPRGAGSYTIMVLFADQATPTSPIRVKV------EPSHDASKVKA 877

Query: 708  DIPINISETDLSLLTATV----VPPSGREEPCL-LKRLRNGHV--------------GIS 830
            + P  +S T + L   T        +G+ +P +    L  G                 + 
Sbjct: 878  EGP-GLSRTGVELGKPTHFTINAKAAGKGKPDVQFSGLAKGDAVRDVDIIDHHDNTYTVK 936

Query: 831  FVPKETGEHLVHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEGHTFEPAEFII 1010
            + P + G   ++V   G  +  SP  V +S S   D S+++VSG G  +    +  EF +
Sbjct: 937  YTPVQQGPVGINVTYGGDPIPKSPFSVGVSPSL--DLSKIKVSGLG-EKVDVGKDQEFTV 993

Query: 1011 DTRDAG-YGGLSLSIEGPSKVDINTEDLEDG----TCRVTYCPTEPGNYIINIKFADQHV 1175
             ++ AG  G ++  I GPS   +  + +E G       V + P E G Y + + +    V
Sbjct: 994  KSKGAGGQGKVASKITGPSGTAVPCK-VEPGLGADNSVVRFVPREEGPYEVEVTYDGVPV 1052

Query: 1176 PGSPFSVKV---TGEGRVKESITRRQRAPSVANVGSHCDLSLKIPEISIQDMTAQVTSPS 1346
            PGSPF V+    T   +VK      Q      + GS    ++      +  +   V  P 
Sbjct: 1053 PGSPFPVEALPPTKPSKVKAFGPGLQGG----SAGSPARFTIDTKGAGMGGLGLTVEGPC 1108

Query: 1347 GKSHEAEIVEGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVR 1526
                + E ++  + T  + +VP E G + +++ +   H+PGSPF+  V P  +  A KV+
Sbjct: 1109 --EAQLECLDNGDGTCSVSYVPTEPGDYNINILFADTHIPGSPFKAHVVPCFD--ASKVK 1164

Query: 1527 AGGPGLERAEAGVPAEFSIWTREAGAGGLAIAV--EGPSKAEISFEDRKDGSCGVAYVVQ 1700
              GPGLERA AG   +F +    AG+  L I +  E    AE+  +D  DG+  + Y+  
Sbjct: 1165 CSGPGLERATAGEAGQFHVDCSSAGSAELTIEIRSEAGLPAEVHIQDHGDGTHTITYIPL 1224

Query: 1701 EPGDYEVSVKFNEEHIPDSPFVVPVASPSGDARRLTV--SSLQESGLKVNQPASFAVSLN 1874
             PG Y V++K+  + +P+ P  + V  P+ D   +      ++  G+       F+V   
Sbjct: 1225 CPGAYTVTIKYGGQPVPNFPSKLQV-EPAVDTSGVQCYGPGIEGQGVFREATTEFSVDAR 1283

Query: 1875 GAKGA----IDAKVHSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGS 2042
                     + A+V +PSG L E YV +     Y V + P E G++ +DV ++G+ +P S
Sbjct: 1284 ALTQTGGPHVKARVANPSGNLTETYVQDCGDGTYKVEYTPYEEGLHSVDVTYDGSPVPSS 1343

Query: 2043 PFKIRVGEPGHGGDPGLVSAYGAGLEGGVTGSPAEFIVNTSNAGAGALSVTIDGPSKVKM 2222
            PF++ V E   G DP  V  +G G++ G T  P +F V T  AG G L + ++GPS+ KM
Sbjct: 1344 PFQVPVTE---GCDPSRVRVHGPGIQSGTTNKPNKFTVETRGAGTGGLGLAVEGPSEAKM 1400

Query: 2223 DCQECPEGY-RVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSV 2399
             C +  +G   V Y P   G+Y +++ YGG + + GSPFK  V           H+ +  
Sbjct: 1401 SCMDNKDGSCSVEYIPYEAGTYSLNVTYGG-HQVPGSPFKVPV-----------HDVTDA 1448

Query: 2400 FVDSLTKTXXXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQK--GSFTVDCSKAGNNMLL 2573
                                    SKV   G GLS   V      SF VD SKAG   L 
Sbjct: 1449 ------------------------SKVKCSGPGLSPGMVRANLPQSFQVDTSKAGVAPLQ 1484

Query: 2574 VGVHGPRTPCEEILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLV 2738
            V V GP+   E + V        +V+Y+   +G Y++ V +G+E +P SP++V V
Sbjct: 1485 VKVQGPKGLVEPVDVVDNADGTQTVNYVPSREGPYSISVLYGEEEVPRSPFKVKV 1539



 Score =  286 bits (733), Expect = 6e-77
 Identities = 248/893 (27%), Positives = 386/893 (43%), Gaps = 47/893 (5%)
 Frame = +3

Query: 201  KGEITGEVRMPSGKVAQPAITDNKDG--TVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQF 374
            +GE+   V  P+G   +  +T N D   T +V Y P   G H++ + +   HI  SP + 
Sbjct: 313  QGEVLVYVEDPAGHQEEAKVTANNDKNRTFSVWYVPEVTGTHKVTVLFAGQHIAKSPFEV 372

Query: 375  YVD--YVNCGHVTAYGPGL--SHGVVNKPAVFTVNTKDAGEGGLSLAIEGPS----KAEI 530
            YVD    +   VTA GPGL  S  + NK   F + T  AG G + + I+ P+      E 
Sbjct: 373  YVDKSQGDASKVTAQGPGLEPSGNIANKTTYFEIFTAGAGTGEVEVVIQDPTGQKGTVEP 432

Query: 531  SCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARV----------TGDDSMRM 680
                  D T   SY P + G +++ V +    IP SP+T  V               ++ 
Sbjct: 433  QLEARGDSTYRCSYQPTMEGVHTVHVTFAGVPIPRSPYTVTVGQACNPGACRAVGRGLQP 492

Query: 681  SHLKVGSAADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHL 860
              ++V   AD  +         L  TV  P G EE    K L +G  G  + P   G + 
Sbjct: 493  KGVRVKETADFKVYTKGAGSGDLKVTVKGPKG-EERVKQKDLGDGVYGFEYYPMVPGTYT 551

Query: 861  VHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEGHTFEPAEFIIDTRDAGYGGL 1040
            V +   GQ++  SP  V +  +E G+  +VR  G GL  G   + A+F+++      G L
Sbjct: 552  VTITWGGQNIGRSPFEVKVG-TECGN-QKVRAWGPGLEGGVVGKSADFVVEAIGDDVGTL 609

Query: 1041 SLSIEGPSKVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTGEGRV 1220
              S+EGPS+  I  +D  DG+C V Y P E G Y +++    + +  SPF   +    + 
Sbjct: 610  GFSVEGPSQAKIECDDKGDGSCDVRYWPQEAGEYAVHVLCNSEDIRLSPFMADIREAPQD 669

Query: 1221 KESITRRQRAPSVANVG----SHCDLSLKIPEISIQDMTAQVTSPSGKSHEAEIVEGENH 1388
                  + R P +   G       + ++         +  QV    G   +A + +  N 
Sbjct: 670  FHPDRVKARGPGLEKTGVAVNKPAEFTVDAKHGGKAALRVQVQDNEGCPVDATVKDNGNG 729

Query: 1389 TYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAH--KVRAGGPGLERA--E 1556
            TY   +VP +   HT  V + G  +P SPF+  VG     G+H  KV+  GPG+ +   +
Sbjct: 730  TYSCSYVPRKPVKHTAMVSWGGVSIPNSPFRVNVG----AGSHPNKVKVYGPGVAKTGLK 785

Query: 1557 AGVPAEFSIWTREAGAGGLAIAVE------GPSKAEISFE--DRKDGSCGVAYVVQEPGD 1712
            A  P  F++   EAG G ++I ++      GP++A+I F+     + +  V Y  +  G 
Sbjct: 786  AHEPTYFTVDCTEAGQGDVSIGIKCAPGVVGPTEADIDFDIIRNDNDTFTVKYTPRGAGS 845

Query: 1713 YEVSVKFNEEHIPDSPFVVPVASPSGDARRLTVS--SLQESGLKVNQPASFAVSLNGA-K 1883
            Y + V F ++  P SP  V V  PS DA ++      L  +G+++ +P  F ++   A K
Sbjct: 846  YTIMVLFADQATPTSPIRVKV-EPSHDASKVKAEGPGLSRTGVELGKPTHFTINAKAAGK 904

Query: 1884 GAIDAKVH--SPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIR 2057
            G  D +    +   A+ +  + +   + Y V++ P + G   I+V + G  IP SPF + 
Sbjct: 905  GKPDVQFSGLAKGDAVRDVDIIDHHDNTYTVKYTPVQQGPVGINVTYGGDPIPKSPFSVG 964

Query: 2058 VGEPGHGGDPGLVSAYGAGLEGGVTGSPAEFIVNTSNAGA-GALSVTIDGPSKVKMDCQE 2234
            V       D   +   G G +  V G   EF V +  AG  G ++  I GPS   + C+ 
Sbjct: 965  VSP---SLDLSKIKVSGLGEKVDV-GKDQEFTVKSKGAGGQGKVASKITGPSGTAVPCKV 1020

Query: 2235 CP----EGYRVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSVF 2402
             P    +   V + P   G Y + + Y G   + GSPF                      
Sbjct: 1021 EPGLGADNSVVRFVPREEGPYEVEVTYDG-VPVPGSPFP--------------------- 1058

Query: 2403 VDSLTKTXXXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKAGNNMLLVGV 2582
            V++L  T                SKV A G GL     G    FT+D   AG   L + V
Sbjct: 1059 VEALPPT--------------KPSKVKAFGPGLQGGSAGSPARFTIDTKGAGMGGLGLTV 1104

Query: 2583 HGPRTPCE-EILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLV 2738
             G   PCE ++     G    SVSY+  + G+Y + + + D HIPGSP++  V
Sbjct: 1105 EG---PCEAQLECLDNGDGTCSVSYVPTEPGDYNINILFADTHIPGSPFKAHV 1154



 Score =  273 bits (699), Expect = 6e-73
 Identities = 241/887 (27%), Positives = 384/887 (43%), Gaps = 42/887 (4%)
 Frame = +3

Query: 204  GEITGEVRMPSGKVAQPAITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFYVD 383
            G++   V+ P G+  +    D  DG     Y P   G + + I +   +I  SP +  V 
Sbjct: 513  GDLKVTVKGPKGE-ERVKQKDLGDGVYGFEYYPMVPGTYTVTITWGGQNIGRSPFEVKVG 571

Query: 384  YVNCGH--VTAYGPGLSHGVVNKPAVFTVNTKDAGEGGLSLAIEGPSKAEISCTDNQDGT 557
               CG+  V A+GPGL  GVV K A F V       G L  ++EGPS+A+I C D  DG+
Sbjct: 572  -TECGNQKVRAWGPGLEGGVVGKSADFVVEAIGDDVGTLGFSVEGPSQAKIECDDKGDGS 630

Query: 558  CSVSYLPVLPGDYSILVKYNEQHIPGSPFTARV-------------TGDDSMRMSHLKVG 698
            C V Y P   G+Y++ V  N + I  SPF A +                  +  + + V 
Sbjct: 631  CDVRYWPQEAGEYAVHVLCNSEDIRLSPFMADIREAPQDFHPDRVKARGPGLEKTGVAVN 690

Query: 699  SAADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKN 878
              A+  ++      + L   V    G      +K   NG    S+VP++  +H   V   
Sbjct: 691  KPAEFTVDAKHGGKAALRVQVQDNEGCPVDATVKDNGNGTYSCSYVPRKPVKHTAMVSWG 750

Query: 879  GQHVASSPIPVVISQSEIGDASRVRVSGRGLHEG--HTFEPAEFIIDTRDAGYGGLSLSI 1052
            G  + +SP  V +        ++V+V G G+ +      EP  F +D  +AG G +S+ I
Sbjct: 751  GVSIPNSPFRVNVGAG--SHPNKVKVYGPGVAKTGLKAHEPTYFTVDCTEAGQGDVSIGI 808

Query: 1053 E------GPSKVDINTEDL--EDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVT- 1205
            +      GP++ DI+ + +  ++ T  V Y P   G+Y I + FADQ  P SP  VKV  
Sbjct: 809  KCAPGVVGPTEADIDFDIIRNDNDTFTVKYTPRGAGSYTIMVLFADQATPTSPIRVKVEP 868

Query: 1206 --GEGRVKESITRRQRAPSVANVGSHCDLSLKIPEISIQDMTAQVTSPSGKSHEAEIVEG 1379
                 +VK       R        +H  ++ K       D+     +      + +I++ 
Sbjct: 869  SHDASKVKAEGPGLSRTGVELGKPTHFTINAKAAGKGKPDVQFSGLAKGDAVRDVDIIDH 928

Query: 1380 ENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLERAEA 1559
             ++TY +++ P + G   ++V Y G  +P SPF   V P  +    K++  G G E+ + 
Sbjct: 929  HDNTYTVKYTPVQQGPVGINVTYGGDPIPKSPFSVGVSPSLD--LSKIKVSGLG-EKVDV 985

Query: 1560 GVPAEFSIWTREAGA-GGLAIAVEGPSKAEISFEDR----KDGSCGVAYVVQEPGDYEVS 1724
            G   EF++ ++ AG  G +A  + GPS   +  +       D S  V +V +E G YEV 
Sbjct: 986  GKDQEFTVKSKGAGGQGKVASKITGPSGTAVPCKVEPGLGADNSV-VRFVPREEGPYEVE 1044

Query: 1725 VKFNEEHIPDSPFVVPVASPSGDARRLTVSSLQESGLKVNQPASFAVSLNGA-KGAIDAK 1901
            V ++   +P SPF V    P+  ++        + G     PA F +   GA  G +   
Sbjct: 1045 VTYDGVPVPGSPFPVEALPPTKPSKVKAFGPGLQGG-SAGSPARFTIDTKGAGMGGLGLT 1103

Query: 1902 VHSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGG 2081
            V  P  A  EC   +      +V ++P E G Y I++ F  THIPGSPFK  V       
Sbjct: 1104 VEGPCEAQLEC--LDNGDGTCSVSYVPTEPGDYNINILFADTHIPGSPFKAHVVP---CF 1158

Query: 2082 DPGLVSAYGAGLEGGVTGSPAEFIVNTSNAGAGALSVTI--DGPSKVKMDCQECPEG-YR 2252
            D   V   G GLE    G   +F V+ S+AG+  L++ I  +     ++  Q+  +G + 
Sbjct: 1159 DASKVKCSGPGLERATAGEAGQFHVDCSSAGSAELTIEIRSEAGLPAEVHIQDHGDGTHT 1218

Query: 2253 VTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSVFVDSLTKTXXX 2432
            +TY P+ PG+Y ++IKYGG   +   P K +V                  VD+       
Sbjct: 1219 ITYIPLCPGAYTVTIKYGG-QPVPNFPSKLQV---------------EPAVDT------- 1255

Query: 2433 XXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGS--FTVDC---SKAGNNMLLVGVHGPRT 2597
                         S V   G G+    V ++ +  F+VD    ++ G   +   V  P  
Sbjct: 1256 -------------SGVQCYGPGIEGQGVFREATTEFSVDARALTQTGGPHVKARVANPSG 1302

Query: 2598 PCEEILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLV 2738
               E  V+  G   Y V Y   ++G +++ V +    +P SP++V V
Sbjct: 1303 NLTETYVQDCGDGTYKVEYTPYEEGLHSVDVTYDGSPVPSSPFQVPV 1349



 Score =  226 bits (577), Expect = 8e-59
 Identities = 230/843 (27%), Positives = 366/843 (43%), Gaps = 50/843 (5%)
 Frame = +3

Query: 354  PGSPLQFYVDYVNCGHVTAYGPGL--SHGVVNKPAVFTVNTKDAGEGGLSLAIEGPS--- 518
            PG+PL+     +N     AYGPG+  +  +V K A FTV T+ AG+G + + +E P+   
Sbjct: 271  PGAPLR---PKLNPKKARAYGPGIEPTGNMVKKRAEFTVETRSAGQGEVLVYVEDPAGHQ 327

Query: 519  -KAEISCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARV--TGDDSMRMSHL 689
             +A+++  ++++ T SV Y+P + G + + V +  QHI  SPF   V  +  D+ +++  
Sbjct: 328  EEAKVTANNDKNRTFSVWYVPEVTGTHKVTVLFAGQHIAKSPFEVYVDKSQGDASKVTAQ 387

Query: 690  KVGSAADIPINISETDLSLLTA---------TVVPPSGRE---EPCLLKRLRNGHVGISF 833
              G      I    T   + TA          +  P+G++   EP L  R  +     S+
Sbjct: 388  GPGLEPSGNIANKTTYFEIFTAGAGTGEVEVVIQDPTGQKGTVEPQLEAR-GDSTYRCSY 446

Query: 834  VPKETGEHLVHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEG--HTFEPAEFI 1007
             P   G H VHV   G  +  SP  V + Q+   +    R  GRGL        E A+F 
Sbjct: 447  QPTMEGVHTVHVTFAGVPIPRSPYTVTVGQA--CNPGACRAVGRGLQPKGVRVKETADFK 504

Query: 1008 IDTRDAGYGGLSLSIEGPSKVD-INTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGS 1184
            + T+ AG G L ++++GP   + +  +DL DG     Y P  PG Y + I +  Q++  S
Sbjct: 505  VYTKGAGSGDLKVTVKGPKGEERVKQKDLGDGVYGFEYYPMVPGTYTVTITWGGQNIGRS 564

Query: 1185 PFSVKVTGE-GRVKESITRRQRAPSVAN--VGSHCDLSLKIPEISIQDMTAQVTSPSGKS 1355
            PF VKV  E G  K     R   P +    VG   D  ++     +  +   V  PS   
Sbjct: 565  PFEVKVGTECGNQKV----RAWGPGLEGGVVGKSADFVVEAIGDDVGTLGFSVEGPSQAK 620

Query: 1356 HEAEIVEGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEG-GAHKVRAG 1532
             E +  +  + +  +R+ P E G + V V    + +  SPF   +    +     +V+A 
Sbjct: 621  IECD--DKGDGSCDVRYWPQEAGEYAVHVLCNSEDIRLSPFMADIREAPQDFHPDRVKAR 678

Query: 1533 GPGLERAEAGV--PAEFSIWTREAGAGGLAIAVEGPS--KAEISFEDRKDGSCGVAYVVQ 1700
            GPGLE+    V  PAEF++  +  G   L + V+       + + +D  +G+   +YV +
Sbjct: 679  GPGLEKTGVAVNKPAEFTVDAKHGGKAALRVQVQDNEGCPVDATVKDNGNGTYSCSYVPR 738

Query: 1701 EPGDYEVSVKFNEEHIPDSPFVVPVASPSGDAR-RLTVSSLQESGLKVNQPASFAVSLNG 1877
            +P  +   V +    IP+SPF V V + S   + ++    + ++GLK ++P  F V    
Sbjct: 739  KPVKHTAMVSWGGVSIPNSPFRVNVGAGSHPNKVKVYGPGVAKTGLKAHEPTYFTVDCTE 798

Query: 1878 A-KGAIDAKVH------SPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIP 2036
            A +G +   +        P+ A  +  +   D D + V++ PR  G Y I V F     P
Sbjct: 799  AGQGDVSIGIKCAPGVVGPTEADIDFDIIRNDNDTFTVKYTPRGAGSYTIMVLFADQATP 858

Query: 2037 GSPFKIRVGEPGHGGDPGLVSAYGAGLE--GGVTGSPAEFIVNTSNAGAGALSVTIDGPS 2210
             SP +++V EP H  D   V A G GL   G   G P  F +N   AG G   V   G +
Sbjct: 859  TSPIRVKV-EPSH--DASKVKAEGPGLSRTGVELGKPTHFTINAKAAGKGKPDVQFSGLA 915

Query: 2211 K----VKMDCQECPEG-YRVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNH 2375
            K      +D  +  +  Y V YTP+  G   I++ YGG   I  SPF   V+        
Sbjct: 916  KGDAVRDVDIIDHHDNTYTVKYTPVQQGPVGINVTYGGD-PIPKSPFSVGVS-------- 966

Query: 2376 SLHETSSVFVDSLTKTXXXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKA 2555
                                            SK+   GLG  K  VG+   FTV    A
Sbjct: 967  ---------------------------PSLDLSKIKVSGLG-EKVDVGKDQEFTVKSKGA 998

Query: 2556 GNN----MLLVGVHGPRTPCEEILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSP 2723
            G        + G  G   PC+  +   +G+    V ++ +++G Y + V +    +PGSP
Sbjct: 999  GGQGKVASKITGPSGTAVPCK--VEPGLGADNSVVRFVPREEGPYEVEVTYDGVPVPGSP 1056

Query: 2724 YRV 2732
            + V
Sbjct: 1057 FPV 1059


>ref|XP_867510.1| PREDICTED: similar to Filamin A (Alpha-filamin) (Filamin 1)
            (Endothelial actin-binding protein) (Actin-binding
            protein 280) (ABP-280) (Nonmuscle filamin) isoform 5
            [Canis familiaris].
          Length = 2605

 Score = 1661 bits (4301), Expect = 0.0
 Identities = 832/913 (91%), Positives = 841/913 (92%)
 Frame = +3

Query: 3    PFQVTALAGEQPSVXXXXXXXXXXXXYTYAQGGQQTWAPERPLVGVNGLDVTSLRPFDLV 182
            PFQVTALAG+QP+             YTYAQGGQQTWAPERPL+GVNGLDVTSLRPFDLV
Sbjct: 1735 PFQVTALAGDQPAAQPPLRPQQLAPPYTYAQGGQQTWAPERPLMGVNGLDVTSLRPFDLV 1794

Query: 183  IPFTIKKGEITGEVRMPSGKVAQPAITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGS 362
            IPFTIKKGEITGEVRMPSGKVAQPAITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGS
Sbjct: 1795 IPFTIKKGEITGEVRMPSGKVAQPAITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGS 1854

Query: 363  PLQFYVDYVNCGHVTAYGPGLSHGVVNKPAVFTVNTKDAGEGGLSLAIEGPSKAEISCTD 542
            PLQFYVDYVNCGHVTAYGPGL+HGVVNKPAVFTVNTKDAGEGGLSLAIEGPSKAEISCTD
Sbjct: 1855 PLQFYVDYVNCGHVTAYGPGLTHGVVNKPAVFTVNTKDAGEGGLSLAIEGPSKAEISCTD 1914

Query: 543  NQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARVTGDDSMRMSHLKVGSAADIPIN 722
            NQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARVTGDDSMRMSHLKVGSAADIPIN
Sbjct: 1915 NQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARVTGDDSMRMSHLKVGSAADIPIN 1974

Query: 723  ISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNGQHVASSP 902
            ISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNGQHVASSP
Sbjct: 1975 ISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNGQHVASSP 2034

Query: 903  IPVVISQSEIGDASRVRVSGRGLHEGHTFEPAEFIIDTRDAGYGGLSLSIEGPSKVDINT 1082
            IPVVISQSEIGDASRVRVSG+GLHEGHTFEPAEFIIDTRDAGYGGLSLSIEGPSKVDINT
Sbjct: 2035 IPVVISQSEIGDASRVRVSGQGLHEGHTFEPAEFIIDTRDAGYGGLSLSIEGPSKVDINT 2094

Query: 1083 EDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTGEGRVKESITRRQRAPSVA 1262
            EDLEDGTCRVTYCPTEPGNYIINIKFADQHVP                            
Sbjct: 2095 EDLEDGTCRVTYCPTEPGNYIINIKFADQHVP---------------------------- 2126

Query: 1263 NVGSHCDLSLKIPEISIQDMTAQVTSPSGKSHEAEIVEGENHTYCIRFVPAEMGMHTVSV 1442
                         EISIQDMTAQVTSPSGK+HEAEIVEGENHTYCIRFVPAEMGMHTVSV
Sbjct: 2127 -------------EISIQDMTAQVTSPSGKTHEAEIVEGENHTYCIRFVPAEMGMHTVSV 2173

Query: 1443 KYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLERAEAGVPAEFSIWTREAGAGGLAIA 1622
            KYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLERAEAGVPAEFSIWTREAGAGGLAIA
Sbjct: 2174 KYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLERAEAGVPAEFSIWTREAGAGGLAIA 2233

Query: 1623 VEGPSKAEISFEDRKDGSCGVAYVVQEPGDYEVSVKFNEEHIPDSPFVVPVASPSGDARR 1802
            VEGPSKAEISFEDRKDGSCGVAYVVQEPGDYEVSVKFNEEHIPDSPFVVPVASPSGDARR
Sbjct: 2234 VEGPSKAEISFEDRKDGSCGVAYVVQEPGDYEVSVKFNEEHIPDSPFVVPVASPSGDARR 2293

Query: 1803 LTVSSLQESGLKVNQPASFAVSLNGAKGAIDAKVHSPSGALEECYVTEIDQDKYAVRFIP 1982
            LTVSSLQESGLKVNQPASFAVSLNGAKGAIDAKVHSPSGALEECYVTEIDQDKYAVRFIP
Sbjct: 2294 LTVSSLQESGLKVNQPASFAVSLNGAKGAIDAKVHSPSGALEECYVTEIDQDKYAVRFIP 2353

Query: 1983 RENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPGLVSAYGAGLEGGVTGSPAEFIVNT 2162
            RENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPGLVSAYGAGLEGGVTGSPAEFIVNT
Sbjct: 2354 RENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPGLVSAYGAGLEGGVTGSPAEFIVNT 2413

Query: 2163 SNAGAGALSVTIDGPSKVKMDCQECPEGYRVTYTPMAPGSYLISIKYGGPYHIGGSPFKA 2342
            SNAGAGALSVTIDGPSKVKMDCQECPEGYRVTYTPMAPGSYLISIKYGGPYHIGGSPFKA
Sbjct: 2414 SNAGAGALSVTIDGPSKVKMDCQECPEGYRVTYTPMAPGSYLISIKYGGPYHIGGSPFKA 2473

Query: 2343 RVTGHRLVSNHSLHETSSVFVDSLTKTXXXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQ 2522
            +VTG RLVSNHSLHETSSVFVDSLTKT                SKVLAKGLGLSKAYVGQ
Sbjct: 2474 KVTGPRLVSNHSLHETSSVFVDSLTKT-ASAPQHGALAGSTDASKVLAKGLGLSKAYVGQ 2532

Query: 2523 KGSFTVDCSKAGNNMLLVGVHGPRTPCEEILVKHVGSRLYSVSYLLKDKGEYTLVVKWGD 2702
            K SFTVDCSKAGNNMLLVGVHGPRTPCEEILVKHVG+RLY+VSYLLKDKGEYTLVVKWGD
Sbjct: 2533 KSSFTVDCSKAGNNMLLVGVHGPRTPCEEILVKHVGNRLYNVSYLLKDKGEYTLVVKWGD 2592

Query: 2703 EHIPGSPYRVLVP 2741
            EHIPGSPYRVLVP
Sbjct: 2593 EHIPGSPYRVLVP 2605



 Score =  427 bits (1098), Expect = e-119
 Identities = 293/904 (32%), Positives = 441/904 (48%), Gaps = 73/904 (8%)
 Frame = +3

Query: 246  AQPAITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFYV-DYVNCGHVTAYGPG 422
            A+ +  DNKDG+ +V Y P EAG + +++ Y    +PGSP +  V D  +   V   GPG
Sbjct: 1398 AKMSCMDNKDGSCSVEYIPYEAGTYSLNVTYGGHQVPGSPFKVPVHDVTDASKVKCSGPG 1457

Query: 423  LSHGVV--NKPAVFTVNTKDAGEGGLSLAIEGPSKA--EISCTDNQDGTCSVSYLPVLPG 590
            LS G+V  N P  F V+T  AG   L + ++GP      +   DN DGT +V+Y+P   G
Sbjct: 1458 LSPGMVRANLPQSFQVDTSKAGVAPLQVKVQGPKGLVEPVDVVDNADGTQTVNYVPSREG 1517

Query: 591  DYSILVKYNEQHIPGSPFTARV--TGDDS--------MRMSHLKVGSAADIPINISETDL 740
             YSI V Y E+ +P SPF  +V  T D S        +  + +      +  I+  +   
Sbjct: 1518 PYSISVLYGEEEVPRSPFKVKVLPTHDASKVKASGPGLNTTGVPASLPVEFTIDAKDAGE 1577

Query: 741  SLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNGQHVASSPIPVVIS 920
             LL   +  P G+ +   ++   +G   +++VP  TG + + +K  G  +  SP  V   
Sbjct: 1578 GLLAVQITDPEGKPKKTHIQDNHDGTYTVAYVPDVTGRYTILIKYGGDEIPFSPYRVRAV 1637

Query: 921  QSEIGDASR----VRVSGRGLHEG-----HTFEPAEFIIDTRDAGYGGLSLSIEGP--SK 1067
             +  GDAS+    V + G GL  G        E     +DT+ AG G ++ ++  P  S+
Sbjct: 1638 PT--GDASKCTVTVSIGGHGLGAGIGPTIQIGEETVITVDTKAAGKGKVTCTVCTPDGSE 1695

Query: 1068 VDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTG--EGRVKESITRR 1241
            VD++  + EDGT  + Y   +PG Y+I ++F  +HVP SPF V      +   +  +  +
Sbjct: 1696 VDVDVVENEDGTFDIFYTAPQPGKYVICVRFGGEHVPNSPFQVTALAGDQPAAQPPLRPQ 1755

Query: 1242 QRAPSVA---------------------NVGSHCDLSLKIP-EISIQDMTAQVTSPSGKS 1355
            Q AP                        +V S     L IP  I   ++T +V  PSGK 
Sbjct: 1756 QLAPPYTYAQGGQQTWAPERPLMGVNGLDVTSLRPFDLVIPFTIKKGEITGEVRMPSGKV 1815

Query: 1356 HEAEIVEGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGG 1535
             +  I + ++ T  +R+ P+E G+H + ++Y   H+PGSP QF V  +  G    V A G
Sbjct: 1816 AQPAITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFYVDYVNCG---HVTAYG 1872

Query: 1536 PGLERAEAGVPAEFSIWTREAGAGGLAIAVEGPSKAEISFEDRKDGSCGVAYVVQEPGDY 1715
            PGL       PA F++ T++AG GGL++A+EGPSKAEIS  D +DG+C V+Y+   PGDY
Sbjct: 1873 PGLTHGVVNKPAVFTVNTKDAGEGGLSLAIEGPSKAEISCTDNQDGTCSVSYLPVLPGDY 1932

Query: 1716 EVSVKFNEEHIPDSPFVVPVASPSGDARRLTVSSLQESGLKVNQPASFAVSLNGAK-GAI 1892
             + VK+NE+HIP SPF   V   +GD       S++ S LKV   A   ++++      +
Sbjct: 1933 SILVKYNEQHIPGSPFTARV---TGD------DSMRMSHLKVGSAADIPINISETDLSLL 1983

Query: 1893 DAKVHSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPG 2072
             A V  PSG  E C +  +      + F+P+E G +L+ VK NG H+  SP  + + +  
Sbjct: 1984 TATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNGQHVASSPIPVVISQ-S 2042

Query: 2073 HGGDPGLVSAYGAGLEGGVTGSPAEFIVNTSNAGAGALSVTIDGPSKVKMDCQECPEG-Y 2249
              GD   V   G GL  G T  PAEFI++T +AG G LS++I+GPSKV ++ ++  +G  
Sbjct: 2043 EIGDASRVRVSGQGLHEGHTFEPAEFIIDTRDAGYGGLSLSIEGPSKVDINTEDLEDGTC 2102

Query: 2250 RVTYTPMAPGSYLISIKYGGPY--HIGGSPFKARVTGH-------------------RLV 2366
            RVTY P  PG+Y+I+IK+   +   I      A+VT                     R V
Sbjct: 2103 RVTYCPTEPGNYIINIKFADQHVPEISIQDMTAQVTSPSGKTHEAEIVEGENHTYCIRFV 2162

Query: 2367 SNHSLHETSSVFVDSLTKTXXXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDC 2546
                   T SV                         KV A G GL +A  G    F++  
Sbjct: 2163 PAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLERAEAGVPAEFSIWT 2222

Query: 2547 SKAGNNMLLVGVHGPRTPCEEILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPY 2726
             +AG   L + V GP     EI  +        V+Y++++ G+Y + VK+ +EHIP SP+
Sbjct: 2223 REAGAGGLAIAVEGPSK--AEISFEDRKDGSCGVAYVVQEPGDYEVSVKFNEEHIPDSPF 2280

Query: 2727 RVLV 2738
             V V
Sbjct: 2281 VVPV 2284



 Score =  347 bits (891), Expect = 3e-95
 Identities = 264/884 (29%), Positives = 409/884 (46%), Gaps = 39/884 (4%)
 Frame = +3

Query: 204  GEITGEVRMPSGK--VAQPAITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFY 377
            GE+   ++ P+G+    +P +    D T    Y P+  G+H + + +  + IP SP    
Sbjct: 414  GEVEVVIQDPTGQKGTVEPQLEARGDSTYRCSYQPTMEGVHTVHVTFAGVPIPRSPYTVT 473

Query: 378  VDYV-NCGHVTAYGPGLS-HGV-VNKPAVFTVNTKDAGEGGLSLAIEGPSKAE-ISCTDN 545
            V    N G   A G GL   GV V + A F V TK AG G L + ++GP   E +   D 
Sbjct: 474  VGQACNPGACRAVGRGLQPKGVRVKETADFKVYTKGAGSGDLKVTVKGPKGEERVKQKDL 533

Query: 546  QDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARV---TGDDSMR-----MSHLKVGS 701
             DG     Y P++PG Y++ + +  Q+I  SPF  +V    G+  +R     +    VG 
Sbjct: 534  GDGVYGFEYYPMVPGTYTVTITWGGQNIGRSPFEVKVGTECGNQKVRAWGPGLEGGVVGK 593

Query: 702  AADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNG 881
            +AD  +     D+  L  +V  PS  +  C  K   +G   + + P+E GE+ VHV  N 
Sbjct: 594  SADFVVEAIGDDVGTLGFSVEGPSQAKIECDDKG--DGSCDVRYWPQEAGEYAVHVLCNS 651

Query: 882  QHVASSPIPVVISQS-EIGDASRVRVSGRGLHEGHTF--EPAEFIIDTRDAGYGGLSLSI 1052
            + +  SP    I ++ +     RV+  G GL +      +PAEF +D +  G   L + +
Sbjct: 652  EDIRLSPFMADIREAPQDFHPDRVKARGPGLEKTGVAVNKPAEFTVDAKHGGKAALRVQV 711

Query: 1053 EGPS--KVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTGEGRVKE 1226
            +      VD   +D  +GT   +Y P +P  +   + +    +P SPF V V G G    
Sbjct: 712  QDNEGCPVDATVKDNGNGTYSCSYVPRKPVKHTAMVSWGGVSIPNSPFRVNV-GAGSHPN 770

Query: 1227 SITRRQRAPSVANVG--SHCDLSLKIP-------EISIQDMTAQ-VTSPSGKSHEAEIVE 1376
             +  +   P VA  G  +H      +        ++SI    A  V  P+    + +I+ 
Sbjct: 771  KV--KVYGPGVAKTGLKAHEPTYFTVDCTEAGQGDVSIGIKCAPGVVGPTEADIDFDIIR 828

Query: 1377 GENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLERA- 1553
             +N T+ +++ P   G +T+ V +  Q  P SP +  V P  +  A KV+A GPGL R  
Sbjct: 829  NDNDTFTVKYTPRGAGSYTIMVLFADQATPTSPIRVKVEPSHD--ASKVKAEGPGLSRTG 886

Query: 1554 -EAGVPAEFSIWTREAGAGGLAIAVEGPSKAE----ISFEDRKDGSCGVAYVVQEPGDYE 1718
             E G P  F+I  + AG G   +   G +K +    +   D  D +  V Y   + G   
Sbjct: 887  VELGKPTHFTINAKAAGKGKPDVQFSGLAKGDAVRDVDIIDHHDNTYTVKYTPVQQGPVG 946

Query: 1719 VSVKFNEEHIPDSPFVVPVASPSGDARRLTVSSLQESGLKVNQPASFAVSLNGA--KGAI 1892
            ++V +  + IP SPF V V SPS D  ++ VS L E  + V +   F V   GA  +G +
Sbjct: 947  INVTYGGDPIPKSPFSVGV-SPSLDLSKIKVSGLGEK-VDVGKDQEFTVKSKGAGGQGKV 1004

Query: 1893 DAKVHSPSGALEECYVTE-IDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEP 2069
             +K+  PSG    C V   +  D   VRF+PRE G Y ++V ++G  +PGSPF +    P
Sbjct: 1005 ASKITGPSGTAVPCKVEPGLGADNSVVRFVPREEGPYEVEVTYDGVPVPGSPFPVEALPP 1064

Query: 2070 GHGGDPGLVSAYGAGLEGGVTGSPAEFIVNTSNAGAGALSVTIDGPSKVKMDCQECPEGY 2249
                 P  V A+G GL+GG  GSPA F ++T  AG G L +T++GP + +++C +  +G 
Sbjct: 1065 TK---PSKVKAFGPGLQGGSAGSPARFTIDTKGAGMGGLGLTVEGPCEAQLECLDNGDGT 1121

Query: 2250 -RVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSVFVDSLTKTX 2426
              V+Y P  PG Y I+I +    HI GSPFKA V                          
Sbjct: 1122 CSVSYVPTEPGDYNINILFADT-HIPGSPFKAHVV------------------------- 1155

Query: 2427 XXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKAGNNMLLVGVHGPRTPCE 2606
                           SKV   G GL +A  G+ G F VDCS AG+  L + +        
Sbjct: 1156 ----------PCFDASKVKCSGPGLERATAGEAGQFHVDCSSAGSAELTIEIRSEAGLPA 1205

Query: 2607 EILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLV 2738
            E+ ++  G   ++++Y+    G YT+ +K+G + +P  P ++ V
Sbjct: 1206 EVHIQDHGDGTHTITYIPLCPGAYTVTIKYGGQPVPNFPSKLQV 1249



 Score =  319 bits (817), Expect = 1e-86
 Identities = 231/760 (30%), Positives = 360/760 (47%), Gaps = 43/760 (5%)
 Frame = +3

Query: 189  FTIK------KGEITGEVRMPSG-----KVAQPAITDNKDGTVTVRYAPSEAGLHEMDIR 335
            FT+K      +G++  ++  PSG     KV      DN      VR+ P E G +E+++ 
Sbjct: 991  FTVKSKGAGGQGKVASKITGPSGTAVPCKVEPGLGADNS----VVRFVPREEGPYEVEVT 1046

Query: 336  YDNMHIPGSPLQFY-VDYVNCGHVTAYGPGLSHGVVNKPAVFTVNTKDAGEGGLSLAIEG 512
            YD + +PGSP     +       V A+GPGL  G    PA FT++TK AG GGL L +EG
Sbjct: 1047 YDGVPVPGSPFPVEALPPTKPSKVKAFGPGLQGGSAGSPARFTIDTKGAGMGGLGLTVEG 1106

Query: 513  PSKAEISCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARVTG--DDSM---- 674
            P +A++ C DN DGTCSVSY+P  PGDY+I + + + HIPGSPF A V    D S     
Sbjct: 1107 PCEAQLECLDNGDGTCSVSYVPTEPGDYNINILFADTHIPGSPFKAHVVPCFDASKVKCS 1166

Query: 675  --RMSHLKVGSAADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKET 848
               +     G A    ++ S    + LT  +   +G      ++   +G   I+++P   
Sbjct: 1167 GPGLERATAGEAGQFHVDCSSAGSAELTIEIRSEAGLPAEVHIQDHGDGTHTITYIPLCP 1226

Query: 849  GEHLVHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEGHTFEPA--EFIIDTR- 1019
            G + V +K  GQ V + P  + +  +   D S V+  G G+     F  A  EF +D R 
Sbjct: 1227 GAYTVTIKYGGQPVPNFPSKLQVEPAV--DTSGVQCYGPGIEGQGVFREATTEFSVDARA 1284

Query: 1020 --DAGYGGLSLSIEGPS--KVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSP 1187
                G   +   +  PS    +   +D  DGT +V Y P E G + +++ +    VP SP
Sbjct: 1285 LTQTGGPHVKARVANPSGNLTETYVQDCGDGTYKVEYTPYEEGLHSVDVTYDGSPVPSSP 1344

Query: 1188 FSVKVTGEGRVKESITRRQRAPSVANVGSHCDLSLKIPEISIQDMTAQVTSPSGKSHEAE 1367
            F V VT EG     +                  +++        +   V  PS    +  
Sbjct: 1345 FQVPVT-EGCDPSRVRVHGPGIQSGTTNKPNKFTVETRGAGTGGLGLAVEGPS--EAKMS 1401

Query: 1368 IVEGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLE 1547
             ++ ++ +  + ++P E G ++++V Y G  VPGSPF+  V  + +  A KV+  GPGL 
Sbjct: 1402 CMDNKDGSCSVEYIPYEAGTYSLNVTYGGHQVPGSPFKVPVHDVTD--ASKVKCSGPGLS 1459

Query: 1548 --RAEAGVPAEFSIWTREAGAGGLAIAVEGPS--KAEISFEDRKDGSCGVAYVVQEPGDY 1715
                 A +P  F + T +AG   L + V+GP      +   D  DG+  V YV    G Y
Sbjct: 1460 PGMVRANLPQSFQVDTSKAGVAPLQVKVQGPKGLVEPVDVVDNADGTQTVNYVPSREGPY 1519

Query: 1716 EVSVKFNEEHIPDSPFVVPVASPSGDARRLTVS--SLQESGLKVNQPASFAVSLNGA-KG 1886
             +SV + EE +P SPF V V  P+ DA ++  S   L  +G+  + P  F +    A +G
Sbjct: 1520 SISVLYGEEEVPRSPFKVKVL-PTHDASKVKASGPGLNTTGVPASLPVEFTIDAKDAGEG 1578

Query: 1887 AIDAKVHSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGE 2066
             +  ++  P G  ++ ++ +     Y V ++P   G Y I +K+ G  IP SP+++R   
Sbjct: 1579 LLAVQITDPEGKPKKTHIQDNHDGTYTVAYVPDVTGRYTILIKYGGDEIPFSPYRVRAVP 1638

Query: 2067 PGHGGDPGL-VSAYGAGLEGGV-----TGSPAEFIVNTSNAGAGALSVTIDGP--SKVKM 2222
             G      + VS  G GL  G+      G      V+T  AG G ++ T+  P  S+V +
Sbjct: 1639 TGDASKCTVTVSIGGHGLGAGIGPTIQIGEETVITVDTKAAGKGKVTCTVCTPDGSEVDV 1698

Query: 2223 DCQECPEG-YRVTYTPMAPGSYLISIKYGGPYHIGGSPFK 2339
            D  E  +G + + YT   PG Y+I +++GG  H+  SPF+
Sbjct: 1699 DVVENEDGTFDIFYTAPQPGKYVICVRFGGE-HVPNSPFQ 1737



 Score =  286 bits (733), Expect = 6e-77
 Identities = 248/893 (27%), Positives = 386/893 (43%), Gaps = 47/893 (5%)
 Frame = +3

Query: 201  KGEITGEVRMPSGKVAQPAITDNKDG--TVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQF 374
            +GE+   V  P+G   +  +T N D   T +V Y P   G H++ + +   HI  SP + 
Sbjct: 313  QGEVLVYVEDPAGHQEEAKVTANNDKNRTFSVWYVPEVTGTHKVTVLFAGQHIAKSPFEV 372

Query: 375  YVD--YVNCGHVTAYGPGL--SHGVVNKPAVFTVNTKDAGEGGLSLAIEGPS----KAEI 530
            YVD    +   VTA GPGL  S  + NK   F + T  AG G + + I+ P+      E 
Sbjct: 373  YVDKSQGDASKVTAQGPGLEPSGNIANKTTYFEIFTAGAGTGEVEVVIQDPTGQKGTVEP 432

Query: 531  SCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARV----------TGDDSMRM 680
                  D T   SY P + G +++ V +    IP SP+T  V               ++ 
Sbjct: 433  QLEARGDSTYRCSYQPTMEGVHTVHVTFAGVPIPRSPYTVTVGQACNPGACRAVGRGLQP 492

Query: 681  SHLKVGSAADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHL 860
              ++V   AD  +         L  TV  P G EE    K L +G  G  + P   G + 
Sbjct: 493  KGVRVKETADFKVYTKGAGSGDLKVTVKGPKG-EERVKQKDLGDGVYGFEYYPMVPGTYT 551

Query: 861  VHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEGHTFEPAEFIIDTRDAGYGGL 1040
            V +   GQ++  SP  V +  +E G+  +VR  G GL  G   + A+F+++      G L
Sbjct: 552  VTITWGGQNIGRSPFEVKVG-TECGN-QKVRAWGPGLEGGVVGKSADFVVEAIGDDVGTL 609

Query: 1041 SLSIEGPSKVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTGEGRV 1220
              S+EGPS+  I  +D  DG+C V Y P E G Y +++    + +  SPF   +    + 
Sbjct: 610  GFSVEGPSQAKIECDDKGDGSCDVRYWPQEAGEYAVHVLCNSEDIRLSPFMADIREAPQD 669

Query: 1221 KESITRRQRAPSVANVG----SHCDLSLKIPEISIQDMTAQVTSPSGKSHEAEIVEGENH 1388
                  + R P +   G       + ++         +  QV    G   +A + +  N 
Sbjct: 670  FHPDRVKARGPGLEKTGVAVNKPAEFTVDAKHGGKAALRVQVQDNEGCPVDATVKDNGNG 729

Query: 1389 TYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAH--KVRAGGPGLERA--E 1556
            TY   +VP +   HT  V + G  +P SPF+  VG     G+H  KV+  GPG+ +   +
Sbjct: 730  TYSCSYVPRKPVKHTAMVSWGGVSIPNSPFRVNVG----AGSHPNKVKVYGPGVAKTGLK 785

Query: 1557 AGVPAEFSIWTREAGAGGLAIAVE------GPSKAEISFE--DRKDGSCGVAYVVQEPGD 1712
            A  P  F++   EAG G ++I ++      GP++A+I F+     + +  V Y  +  G 
Sbjct: 786  AHEPTYFTVDCTEAGQGDVSIGIKCAPGVVGPTEADIDFDIIRNDNDTFTVKYTPRGAGS 845

Query: 1713 YEVSVKFNEEHIPDSPFVVPVASPSGDARRLTVS--SLQESGLKVNQPASFAVSLNGA-K 1883
            Y + V F ++  P SP  V V  PS DA ++      L  +G+++ +P  F ++   A K
Sbjct: 846  YTIMVLFADQATPTSPIRVKV-EPSHDASKVKAEGPGLSRTGVELGKPTHFTINAKAAGK 904

Query: 1884 GAIDAKVH--SPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIR 2057
            G  D +    +   A+ +  + +   + Y V++ P + G   I+V + G  IP SPF + 
Sbjct: 905  GKPDVQFSGLAKGDAVRDVDIIDHHDNTYTVKYTPVQQGPVGINVTYGGDPIPKSPFSVG 964

Query: 2058 VGEPGHGGDPGLVSAYGAGLEGGVTGSPAEFIVNTSNAGA-GALSVTIDGPSKVKMDCQE 2234
            V       D   +   G G +  V G   EF V +  AG  G ++  I GPS   + C+ 
Sbjct: 965  VSP---SLDLSKIKVSGLGEKVDV-GKDQEFTVKSKGAGGQGKVASKITGPSGTAVPCKV 1020

Query: 2235 CP----EGYRVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSVF 2402
             P    +   V + P   G Y + + Y G   + GSPF                      
Sbjct: 1021 EPGLGADNSVVRFVPREEGPYEVEVTYDG-VPVPGSPFP--------------------- 1058

Query: 2403 VDSLTKTXXXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKAGNNMLLVGV 2582
            V++L  T                SKV A G GL     G    FT+D   AG   L + V
Sbjct: 1059 VEALPPT--------------KPSKVKAFGPGLQGGSAGSPARFTIDTKGAGMGGLGLTV 1104

Query: 2583 HGPRTPCE-EILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLV 2738
             G   PCE ++     G    SVSY+  + G+Y + + + D HIPGSP++  V
Sbjct: 1105 EG---PCEAQLECLDNGDGTCSVSYVPTEPGDYNINILFADTHIPGSPFKAHV 1154



 Score =  226 bits (577), Expect = 8e-59
 Identities = 230/843 (27%), Positives = 366/843 (43%), Gaps = 50/843 (5%)
 Frame = +3

Query: 354  PGSPLQFYVDYVNCGHVTAYGPGL--SHGVVNKPAVFTVNTKDAGEGGLSLAIEGPS--- 518
            PG+PL+     +N     AYGPG+  +  +V K A FTV T+ AG+G + + +E P+   
Sbjct: 271  PGAPLR---PKLNPKKARAYGPGIEPTGNMVKKRAEFTVETRSAGQGEVLVYVEDPAGHQ 327

Query: 519  -KAEISCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARV--TGDDSMRMSHL 689
             +A+++  ++++ T SV Y+P + G + + V +  QHI  SPF   V  +  D+ +++  
Sbjct: 328  EEAKVTANNDKNRTFSVWYVPEVTGTHKVTVLFAGQHIAKSPFEVYVDKSQGDASKVTAQ 387

Query: 690  KVGSAADIPINISETDLSLLTA---------TVVPPSGRE---EPCLLKRLRNGHVGISF 833
              G      I    T   + TA          +  P+G++   EP L  R  +     S+
Sbjct: 388  GPGLEPSGNIANKTTYFEIFTAGAGTGEVEVVIQDPTGQKGTVEPQLEAR-GDSTYRCSY 446

Query: 834  VPKETGEHLVHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEG--HTFEPAEFI 1007
             P   G H VHV   G  +  SP  V + Q+   +    R  GRGL        E A+F 
Sbjct: 447  QPTMEGVHTVHVTFAGVPIPRSPYTVTVGQA--CNPGACRAVGRGLQPKGVRVKETADFK 504

Query: 1008 IDTRDAGYGGLSLSIEGPSKVD-INTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGS 1184
            + T+ AG G L ++++GP   + +  +DL DG     Y P  PG Y + I +  Q++  S
Sbjct: 505  VYTKGAGSGDLKVTVKGPKGEERVKQKDLGDGVYGFEYYPMVPGTYTVTITWGGQNIGRS 564

Query: 1185 PFSVKVTGE-GRVKESITRRQRAPSVAN--VGSHCDLSLKIPEISIQDMTAQVTSPSGKS 1355
            PF VKV  E G  K     R   P +    VG   D  ++     +  +   V  PS   
Sbjct: 565  PFEVKVGTECGNQKV----RAWGPGLEGGVVGKSADFVVEAIGDDVGTLGFSVEGPSQAK 620

Query: 1356 HEAEIVEGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEG-GAHKVRAG 1532
             E +  +  + +  +R+ P E G + V V    + +  SPF   +    +     +V+A 
Sbjct: 621  IECD--DKGDGSCDVRYWPQEAGEYAVHVLCNSEDIRLSPFMADIREAPQDFHPDRVKAR 678

Query: 1533 GPGLERAEAGV--PAEFSIWTREAGAGGLAIAVEGPS--KAEISFEDRKDGSCGVAYVVQ 1700
            GPGLE+    V  PAEF++  +  G   L + V+       + + +D  +G+   +YV +
Sbjct: 679  GPGLEKTGVAVNKPAEFTVDAKHGGKAALRVQVQDNEGCPVDATVKDNGNGTYSCSYVPR 738

Query: 1701 EPGDYEVSVKFNEEHIPDSPFVVPVASPSGDAR-RLTVSSLQESGLKVNQPASFAVSLNG 1877
            +P  +   V +    IP+SPF V V + S   + ++    + ++GLK ++P  F V    
Sbjct: 739  KPVKHTAMVSWGGVSIPNSPFRVNVGAGSHPNKVKVYGPGVAKTGLKAHEPTYFTVDCTE 798

Query: 1878 A-KGAIDAKVH------SPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIP 2036
            A +G +   +        P+ A  +  +   D D + V++ PR  G Y I V F     P
Sbjct: 799  AGQGDVSIGIKCAPGVVGPTEADIDFDIIRNDNDTFTVKYTPRGAGSYTIMVLFADQATP 858

Query: 2037 GSPFKIRVGEPGHGGDPGLVSAYGAGLE--GGVTGSPAEFIVNTSNAGAGALSVTIDGPS 2210
             SP +++V EP H  D   V A G GL   G   G P  F +N   AG G   V   G +
Sbjct: 859  TSPIRVKV-EPSH--DASKVKAEGPGLSRTGVELGKPTHFTINAKAAGKGKPDVQFSGLA 915

Query: 2211 K----VKMDCQECPEG-YRVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNH 2375
            K      +D  +  +  Y V YTP+  G   I++ YGG   I  SPF   V+        
Sbjct: 916  KGDAVRDVDIIDHHDNTYTVKYTPVQQGPVGINVTYGGD-PIPKSPFSVGVS-------- 966

Query: 2376 SLHETSSVFVDSLTKTXXXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKA 2555
                                            SK+   GLG  K  VG+   FTV    A
Sbjct: 967  ---------------------------PSLDLSKIKVSGLG-EKVDVGKDQEFTVKSKGA 998

Query: 2556 GNN----MLLVGVHGPRTPCEEILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSP 2723
            G        + G  G   PC+  +   +G+    V ++ +++G Y + V +    +PGSP
Sbjct: 999  GGQGKVASKITGPSGTAVPCK--VEPGLGADNSVVRFVPREEGPYEVEVTYDGVPVPGSP 1056

Query: 2724 YRV 2732
            + V
Sbjct: 1057 FPV 1059


>ref|XP_867520.1| PREDICTED: similar to Filamin A (Alpha-filamin) (Filamin 1)
            (Endothelial actin-binding protein) (Actin-binding
            protein 280) (ABP-280) (Nonmuscle filamin) isoform 6
            [Canis familiaris].
          Length = 2537

 Score = 1549 bits (4011), Expect = 0.0
 Identities = 762/784 (97%), Positives = 771/784 (98%)
 Frame = +3

Query: 3    PFQVTALAGEQPSVXXXXXXXXXXXXYTYAQGGQQTWAPERPLVGVNGLDVTSLRPFDLV 182
            PFQVTALAG+QP+             YTYAQGGQQTWAPERPL+GVNGLDVTSLRPFDLV
Sbjct: 1735 PFQVTALAGDQPAAQPPLRPQQLAPPYTYAQGGQQTWAPERPLMGVNGLDVTSLRPFDLV 1794

Query: 183  IPFTIKKGEITGEVRMPSGKVAQPAITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGS 362
            IPFTIKKGEITGEVRMPSGKVAQPAITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGS
Sbjct: 1795 IPFTIKKGEITGEVRMPSGKVAQPAITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGS 1854

Query: 363  PLQFYVDYVNCGHVTAYGPGLSHGVVNKPAVFTVNTKDAGEGGLSLAIEGPSKAEISCTD 542
            PLQFYVDYVNCGHVTAYGPGL+HGVVNKPAVFTVNTKDAGEGGLSLAIEGPSKAEISCTD
Sbjct: 1855 PLQFYVDYVNCGHVTAYGPGLTHGVVNKPAVFTVNTKDAGEGGLSLAIEGPSKAEISCTD 1914

Query: 543  NQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARVTGDDSMRMSHLKVGSAADIPIN 722
            NQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARVTGDDSMRMSHLKVGSAADIPIN
Sbjct: 1915 NQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARVTGDDSMRMSHLKVGSAADIPIN 1974

Query: 723  ISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNGQHVASSP 902
            ISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNGQHVASSP
Sbjct: 1975 ISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNGQHVASSP 2034

Query: 903  IPVVISQSEIGDASRVRVSGRGLHEGHTFEPAEFIIDTRDAGYGGLSLSIEGPSKVDINT 1082
            IPVVISQSEIGDASRVRVSG+GLHEGHTFEPAEFIIDTRDAGYGGLSLSIEGPSKVDINT
Sbjct: 2035 IPVVISQSEIGDASRVRVSGQGLHEGHTFEPAEFIIDTRDAGYGGLSLSIEGPSKVDINT 2094

Query: 1083 EDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTGEGRVKESITRRQRAPSVA 1262
            EDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTGEGRVKESITRR+RAPSVA
Sbjct: 2095 EDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTGEGRVKESITRRRRAPSVA 2154

Query: 1263 NVGSHCDLSLKIPEISIQDMTAQVTSPSGKSHEAEIVEGENHTYCIRFVPAEMGMHTVSV 1442
            NVGSHC+LSLKIPEISIQDMTAQVTSPSGK+HEAEIVEGENHTYCIRFVPAEMGMHTVSV
Sbjct: 2155 NVGSHCNLSLKIPEISIQDMTAQVTSPSGKTHEAEIVEGENHTYCIRFVPAEMGMHTVSV 2214

Query: 1443 KYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLERAEAGVPAEFSIWTREAGAGGLAIA 1622
            KYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLERAEAGVPAEFSIWTREAGAGGLAIA
Sbjct: 2215 KYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLERAEAGVPAEFSIWTREAGAGGLAIA 2274

Query: 1623 VEGPSKAEISFEDRKDGSCGVAYVVQEPGDYEVSVKFNEEHIPDSPFVVPVASPSGDARR 1802
            VEGPSKAEISFEDRKDGSCGVAYVVQEPGDYEVSVKFNEEHIPDSPFVVPVASPSGDARR
Sbjct: 2275 VEGPSKAEISFEDRKDGSCGVAYVVQEPGDYEVSVKFNEEHIPDSPFVVPVASPSGDARR 2334

Query: 1803 LTVSSLQESGLKVNQPASFAVSLNGAKGAIDAKVHSPSGALEECYVTEIDQDKYAVRFIP 1982
            LTVSSLQESGLKVNQPASFAVSLNGAKGAIDAKVHSPSGALEECYVTEIDQDKYAVRFIP
Sbjct: 2335 LTVSSLQESGLKVNQPASFAVSLNGAKGAIDAKVHSPSGALEECYVTEIDQDKYAVRFIP 2394

Query: 1983 RENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPGLVSAYGAGLEGGVTGSPAEFIVNT 2162
            RENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPGLVSAYGAGLEGGVTGSPAEFIVNT
Sbjct: 2395 RENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPGLVSAYGAGLEGGVTGSPAEFIVNT 2454

Query: 2163 SNAGAGALSVTIDGPSKVKMDCQECPEGYRVTYTPMAPGSYLISIKYGGPYHIGGSPFKA 2342
            SNAGAGALSVTIDGPSKVKMDCQECPEGYRVTYTPMAPGSYLISIKYGGPYHIGGSPFKA
Sbjct: 2455 SNAGAGALSVTIDGPSKVKMDCQECPEGYRVTYTPMAPGSYLISIKYGGPYHIGGSPFKA 2514

Query: 2343 RVTG 2354
            +VTG
Sbjct: 2515 KVTG 2518



 Score =  425 bits (1092), Expect = e-118
 Identities = 282/883 (31%), Positives = 436/883 (49%), Gaps = 52/883 (5%)
 Frame = +3

Query: 246  AQPAITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFYV-DYVNCGHVTAYGPG 422
            A+ +  DNKDG+ +V Y P EAG + +++ Y    +PGSP +  V D  +   V   GPG
Sbjct: 1398 AKMSCMDNKDGSCSVEYIPYEAGTYSLNVTYGGHQVPGSPFKVPVHDVTDASKVKCSGPG 1457

Query: 423  LSHGVV--NKPAVFTVNTKDAGEGGLSLAIEGPSKA--EISCTDNQDGTCSVSYLPVLPG 590
            LS G+V  N P  F V+T  AG   L + ++GP      +   DN DGT +V+Y+P   G
Sbjct: 1458 LSPGMVRANLPQSFQVDTSKAGVAPLQVKVQGPKGLVEPVDVVDNADGTQTVNYVPSREG 1517

Query: 591  DYSILVKYNEQHIPGSPFTARV--TGDDS--------MRMSHLKVGSAADIPINISETDL 740
             YSI V Y E+ +P SPF  +V  T D S        +  + +      +  I+  +   
Sbjct: 1518 PYSISVLYGEEEVPRSPFKVKVLPTHDASKVKASGPGLNTTGVPASLPVEFTIDAKDAGE 1577

Query: 741  SLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNGQHVASSPIPVVIS 920
             LL   +  P G+ +   ++   +G   +++VP  TG + + +K  G  +  SP  V   
Sbjct: 1578 GLLAVQITDPEGKPKKTHIQDNHDGTYTVAYVPDVTGRYTILIKYGGDEIPFSPYRVRAV 1637

Query: 921  QSEIGDASR----VRVSGRGLHEG-----HTFEPAEFIIDTRDAGYGGLSLSIEGP--SK 1067
             +  GDAS+    V + G GL  G        E     +DT+ AG G ++ ++  P  S+
Sbjct: 1638 PT--GDASKCTVTVSIGGHGLGAGIGPTIQIGEETVITVDTKAAGKGKVTCTVCTPDGSE 1695

Query: 1068 VDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTG--EGRVKESITRR 1241
            VD++  + EDGT  + Y   +PG Y+I ++F  +HVP SPF V      +   +  +  +
Sbjct: 1696 VDVDVVENEDGTFDIFYTAPQPGKYVICVRFGGEHVPNSPFQVTALAGDQPAAQPPLRPQ 1755

Query: 1242 QRAPSVA---------------------NVGSHCDLSLKIP-EISIQDMTAQVTSPSGKS 1355
            Q AP                        +V S     L IP  I   ++T +V  PSGK 
Sbjct: 1756 QLAPPYTYAQGGQQTWAPERPLMGVNGLDVTSLRPFDLVIPFTIKKGEITGEVRMPSGKV 1815

Query: 1356 HEAEIVEGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGG 1535
             +  I + ++ T  +R+ P+E G+H + ++Y   H+PGSP QF V  +  G    V A G
Sbjct: 1816 AQPAITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFYVDYVNCG---HVTAYG 1872

Query: 1536 PGLERAEAGVPAEFSIWTREAGAGGLAIAVEGPSKAEISFEDRKDGSCGVAYVVQEPGDY 1715
            PGL       PA F++ T++AG GGL++A+EGPSKAEIS  D +DG+C V+Y+   PGDY
Sbjct: 1873 PGLTHGVVNKPAVFTVNTKDAGEGGLSLAIEGPSKAEISCTDNQDGTCSVSYLPVLPGDY 1932

Query: 1716 EVSVKFNEEHIPDSPFVVPVASPSGDARRLTVSSLQESGLKVNQPASFAVSLNGAK-GAI 1892
             + VK+NE+HIP SPF   V   +GD       S++ S LKV   A   ++++      +
Sbjct: 1933 SILVKYNEQHIPGSPFTARV---TGD------DSMRMSHLKVGSAADIPINISETDLSLL 1983

Query: 1893 DAKVHSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPG 2072
             A V  PSG  E C +  +      + F+P+E G +L+ VK NG H+  SP  + + +  
Sbjct: 1984 TATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNGQHVASSPIPVVISQ-S 2042

Query: 2073 HGGDPGLVSAYGAGLEGGVTGSPAEFIVNTSNAGAGALSVTIDGPSKVKMDCQECPEG-Y 2249
              GD   V   G GL  G T  PAEFI++T +AG G LS++I+GPSKV ++ ++  +G  
Sbjct: 2043 EIGDASRVRVSGQGLHEGHTFEPAEFIIDTRDAGYGGLSLSIEGPSKVDINTEDLEDGTC 2102

Query: 2250 RVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSVFVDSLTKTXX 2429
            RVTY P  PG+Y+I+IK+    H+ GSPF  +VTG   V             +S+T+   
Sbjct: 2103 RVTYCPTEPGNYIINIKF-ADQHVPGSPFSVKVTGEGRVK------------ESITR--- 2146

Query: 2430 XXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKAGNNMLLVGVHGPRTPCEE 2609
                               +    S A VG   + ++   +     +   V  P     E
Sbjct: 2147 -------------------RRRAPSVANVGSHCNLSLKIPEISIQDMTAQVTSPSGKTHE 2187

Query: 2610 ILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLV 2738
              +    +  Y + ++  + G +T+ VK+  +H+PGSP++  V
Sbjct: 2188 AEIVEGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTV 2230



 Score =  347 bits (891), Expect = 3e-95
 Identities = 264/884 (29%), Positives = 409/884 (46%), Gaps = 39/884 (4%)
 Frame = +3

Query: 204  GEITGEVRMPSGK--VAQPAITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFY 377
            GE+   ++ P+G+    +P +    D T    Y P+  G+H + + +  + IP SP    
Sbjct: 414  GEVEVVIQDPTGQKGTVEPQLEARGDSTYRCSYQPTMEGVHTVHVTFAGVPIPRSPYTVT 473

Query: 378  VDYV-NCGHVTAYGPGLS-HGV-VNKPAVFTVNTKDAGEGGLSLAIEGPSKAE-ISCTDN 545
            V    N G   A G GL   GV V + A F V TK AG G L + ++GP   E +   D 
Sbjct: 474  VGQACNPGACRAVGRGLQPKGVRVKETADFKVYTKGAGSGDLKVTVKGPKGEERVKQKDL 533

Query: 546  QDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARV---TGDDSMR-----MSHLKVGS 701
             DG     Y P++PG Y++ + +  Q+I  SPF  +V    G+  +R     +    VG 
Sbjct: 534  GDGVYGFEYYPMVPGTYTVTITWGGQNIGRSPFEVKVGTECGNQKVRAWGPGLEGGVVGK 593

Query: 702  AADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNG 881
            +AD  +     D+  L  +V  PS  +  C  K   +G   + + P+E GE+ VHV  N 
Sbjct: 594  SADFVVEAIGDDVGTLGFSVEGPSQAKIECDDKG--DGSCDVRYWPQEAGEYAVHVLCNS 651

Query: 882  QHVASSPIPVVISQS-EIGDASRVRVSGRGLHEGHTF--EPAEFIIDTRDAGYGGLSLSI 1052
            + +  SP    I ++ +     RV+  G GL +      +PAEF +D +  G   L + +
Sbjct: 652  EDIRLSPFMADIREAPQDFHPDRVKARGPGLEKTGVAVNKPAEFTVDAKHGGKAALRVQV 711

Query: 1053 EGPS--KVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTGEGRVKE 1226
            +      VD   +D  +GT   +Y P +P  +   + +    +P SPF V V G G    
Sbjct: 712  QDNEGCPVDATVKDNGNGTYSCSYVPRKPVKHTAMVSWGGVSIPNSPFRVNV-GAGSHPN 770

Query: 1227 SITRRQRAPSVANVG--SHCDLSLKIP-------EISIQDMTAQ-VTSPSGKSHEAEIVE 1376
             +  +   P VA  G  +H      +        ++SI    A  V  P+    + +I+ 
Sbjct: 771  KV--KVYGPGVAKTGLKAHEPTYFTVDCTEAGQGDVSIGIKCAPGVVGPTEADIDFDIIR 828

Query: 1377 GENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLERA- 1553
             +N T+ +++ P   G +T+ V +  Q  P SP +  V P  +  A KV+A GPGL R  
Sbjct: 829  NDNDTFTVKYTPRGAGSYTIMVLFADQATPTSPIRVKVEPSHD--ASKVKAEGPGLSRTG 886

Query: 1554 -EAGVPAEFSIWTREAGAGGLAIAVEGPSKAE----ISFEDRKDGSCGVAYVVQEPGDYE 1718
             E G P  F+I  + AG G   +   G +K +    +   D  D +  V Y   + G   
Sbjct: 887  VELGKPTHFTINAKAAGKGKPDVQFSGLAKGDAVRDVDIIDHHDNTYTVKYTPVQQGPVG 946

Query: 1719 VSVKFNEEHIPDSPFVVPVASPSGDARRLTVSSLQESGLKVNQPASFAVSLNGA--KGAI 1892
            ++V +  + IP SPF V V SPS D  ++ VS L E  + V +   F V   GA  +G +
Sbjct: 947  INVTYGGDPIPKSPFSVGV-SPSLDLSKIKVSGLGEK-VDVGKDQEFTVKSKGAGGQGKV 1004

Query: 1893 DAKVHSPSGALEECYVTE-IDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEP 2069
             +K+  PSG    C V   +  D   VRF+PRE G Y ++V ++G  +PGSPF +    P
Sbjct: 1005 ASKITGPSGTAVPCKVEPGLGADNSVVRFVPREEGPYEVEVTYDGVPVPGSPFPVEALPP 1064

Query: 2070 GHGGDPGLVSAYGAGLEGGVTGSPAEFIVNTSNAGAGALSVTIDGPSKVKMDCQECPEGY 2249
                 P  V A+G GL+GG  GSPA F ++T  AG G L +T++GP + +++C +  +G 
Sbjct: 1065 TK---PSKVKAFGPGLQGGSAGSPARFTIDTKGAGMGGLGLTVEGPCEAQLECLDNGDGT 1121

Query: 2250 -RVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSVFVDSLTKTX 2426
              V+Y P  PG Y I+I +    HI GSPFKA V                          
Sbjct: 1122 CSVSYVPTEPGDYNINILFADT-HIPGSPFKAHVV------------------------- 1155

Query: 2427 XXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKAGNNMLLVGVHGPRTPCE 2606
                           SKV   G GL +A  G+ G F VDCS AG+  L + +        
Sbjct: 1156 ----------PCFDASKVKCSGPGLERATAGEAGQFHVDCSSAGSAELTIEIRSEAGLPA 1205

Query: 2607 EILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLV 2738
            E+ ++  G   ++++Y+    G YT+ +K+G + +P  P ++ V
Sbjct: 1206 EVHIQDHGDGTHTITYIPLCPGAYTVTIKYGGQPVPNFPSKLQV 1249



 Score =  319 bits (817), Expect = 1e-86
 Identities = 231/760 (30%), Positives = 360/760 (47%), Gaps = 43/760 (5%)
 Frame = +3

Query: 189  FTIK------KGEITGEVRMPSG-----KVAQPAITDNKDGTVTVRYAPSEAGLHEMDIR 335
            FT+K      +G++  ++  PSG     KV      DN      VR+ P E G +E+++ 
Sbjct: 991  FTVKSKGAGGQGKVASKITGPSGTAVPCKVEPGLGADNS----VVRFVPREEGPYEVEVT 1046

Query: 336  YDNMHIPGSPLQFY-VDYVNCGHVTAYGPGLSHGVVNKPAVFTVNTKDAGEGGLSLAIEG 512
            YD + +PGSP     +       V A+GPGL  G    PA FT++TK AG GGL L +EG
Sbjct: 1047 YDGVPVPGSPFPVEALPPTKPSKVKAFGPGLQGGSAGSPARFTIDTKGAGMGGLGLTVEG 1106

Query: 513  PSKAEISCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARVTG--DDSM---- 674
            P +A++ C DN DGTCSVSY+P  PGDY+I + + + HIPGSPF A V    D S     
Sbjct: 1107 PCEAQLECLDNGDGTCSVSYVPTEPGDYNINILFADTHIPGSPFKAHVVPCFDASKVKCS 1166

Query: 675  --RMSHLKVGSAADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKET 848
               +     G A    ++ S    + LT  +   +G      ++   +G   I+++P   
Sbjct: 1167 GPGLERATAGEAGQFHVDCSSAGSAELTIEIRSEAGLPAEVHIQDHGDGTHTITYIPLCP 1226

Query: 849  GEHLVHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEGHTFEPA--EFIIDTR- 1019
            G + V +K  GQ V + P  + +  +   D S V+  G G+     F  A  EF +D R 
Sbjct: 1227 GAYTVTIKYGGQPVPNFPSKLQVEPAV--DTSGVQCYGPGIEGQGVFREATTEFSVDARA 1284

Query: 1020 --DAGYGGLSLSIEGPS--KVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSP 1187
                G   +   +  PS    +   +D  DGT +V Y P E G + +++ +    VP SP
Sbjct: 1285 LTQTGGPHVKARVANPSGNLTETYVQDCGDGTYKVEYTPYEEGLHSVDVTYDGSPVPSSP 1344

Query: 1188 FSVKVTGEGRVKESITRRQRAPSVANVGSHCDLSLKIPEISIQDMTAQVTSPSGKSHEAE 1367
            F V VT EG     +                  +++        +   V  PS    +  
Sbjct: 1345 FQVPVT-EGCDPSRVRVHGPGIQSGTTNKPNKFTVETRGAGTGGLGLAVEGPS--EAKMS 1401

Query: 1368 IVEGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLE 1547
             ++ ++ +  + ++P E G ++++V Y G  VPGSPF+  V  + +  A KV+  GPGL 
Sbjct: 1402 CMDNKDGSCSVEYIPYEAGTYSLNVTYGGHQVPGSPFKVPVHDVTD--ASKVKCSGPGLS 1459

Query: 1548 --RAEAGVPAEFSIWTREAGAGGLAIAVEGPS--KAEISFEDRKDGSCGVAYVVQEPGDY 1715
                 A +P  F + T +AG   L + V+GP      +   D  DG+  V YV    G Y
Sbjct: 1460 PGMVRANLPQSFQVDTSKAGVAPLQVKVQGPKGLVEPVDVVDNADGTQTVNYVPSREGPY 1519

Query: 1716 EVSVKFNEEHIPDSPFVVPVASPSGDARRLTVS--SLQESGLKVNQPASFAVSLNGA-KG 1886
             +SV + EE +P SPF V V  P+ DA ++  S   L  +G+  + P  F +    A +G
Sbjct: 1520 SISVLYGEEEVPRSPFKVKVL-PTHDASKVKASGPGLNTTGVPASLPVEFTIDAKDAGEG 1578

Query: 1887 AIDAKVHSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGE 2066
             +  ++  P G  ++ ++ +     Y V ++P   G Y I +K+ G  IP SP+++R   
Sbjct: 1579 LLAVQITDPEGKPKKTHIQDNHDGTYTVAYVPDVTGRYTILIKYGGDEIPFSPYRVRAVP 1638

Query: 2067 PGHGGDPGL-VSAYGAGLEGGV-----TGSPAEFIVNTSNAGAGALSVTIDGP--SKVKM 2222
             G      + VS  G GL  G+      G      V+T  AG G ++ T+  P  S+V +
Sbjct: 1639 TGDASKCTVTVSIGGHGLGAGIGPTIQIGEETVITVDTKAAGKGKVTCTVCTPDGSEVDV 1698

Query: 2223 DCQECPEG-YRVTYTPMAPGSYLISIKYGGPYHIGGSPFK 2339
            D  E  +G + + YT   PG Y+I +++GG  H+  SPF+
Sbjct: 1699 DVVENEDGTFDIFYTAPQPGKYVICVRFGGE-HVPNSPFQ 1737



 Score =  286 bits (733), Expect = 6e-77
 Identities = 248/893 (27%), Positives = 386/893 (43%), Gaps = 47/893 (5%)
 Frame = +3

Query: 201  KGEITGEVRMPSGKVAQPAITDNKDG--TVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQF 374
            +GE+   V  P+G   +  +T N D   T +V Y P   G H++ + +   HI  SP + 
Sbjct: 313  QGEVLVYVEDPAGHQEEAKVTANNDKNRTFSVWYVPEVTGTHKVTVLFAGQHIAKSPFEV 372

Query: 375  YVD--YVNCGHVTAYGPGL--SHGVVNKPAVFTVNTKDAGEGGLSLAIEGPS----KAEI 530
            YVD    +   VTA GPGL  S  + NK   F + T  AG G + + I+ P+      E 
Sbjct: 373  YVDKSQGDASKVTAQGPGLEPSGNIANKTTYFEIFTAGAGTGEVEVVIQDPTGQKGTVEP 432

Query: 531  SCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARV----------TGDDSMRM 680
                  D T   SY P + G +++ V +    IP SP+T  V               ++ 
Sbjct: 433  QLEARGDSTYRCSYQPTMEGVHTVHVTFAGVPIPRSPYTVTVGQACNPGACRAVGRGLQP 492

Query: 681  SHLKVGSAADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHL 860
              ++V   AD  +         L  TV  P G EE    K L +G  G  + P   G + 
Sbjct: 493  KGVRVKETADFKVYTKGAGSGDLKVTVKGPKG-EERVKQKDLGDGVYGFEYYPMVPGTYT 551

Query: 861  VHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEGHTFEPAEFIIDTRDAGYGGL 1040
            V +   GQ++  SP  V +  +E G+  +VR  G GL  G   + A+F+++      G L
Sbjct: 552  VTITWGGQNIGRSPFEVKVG-TECGN-QKVRAWGPGLEGGVVGKSADFVVEAIGDDVGTL 609

Query: 1041 SLSIEGPSKVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTGEGRV 1220
              S+EGPS+  I  +D  DG+C V Y P E G Y +++    + +  SPF   +    + 
Sbjct: 610  GFSVEGPSQAKIECDDKGDGSCDVRYWPQEAGEYAVHVLCNSEDIRLSPFMADIREAPQD 669

Query: 1221 KESITRRQRAPSVANVG----SHCDLSLKIPEISIQDMTAQVTSPSGKSHEAEIVEGENH 1388
                  + R P +   G       + ++         +  QV    G   +A + +  N 
Sbjct: 670  FHPDRVKARGPGLEKTGVAVNKPAEFTVDAKHGGKAALRVQVQDNEGCPVDATVKDNGNG 729

Query: 1389 TYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAH--KVRAGGPGLERA--E 1556
            TY   +VP +   HT  V + G  +P SPF+  VG     G+H  KV+  GPG+ +   +
Sbjct: 730  TYSCSYVPRKPVKHTAMVSWGGVSIPNSPFRVNVG----AGSHPNKVKVYGPGVAKTGLK 785

Query: 1557 AGVPAEFSIWTREAGAGGLAIAVE------GPSKAEISFE--DRKDGSCGVAYVVQEPGD 1712
            A  P  F++   EAG G ++I ++      GP++A+I F+     + +  V Y  +  G 
Sbjct: 786  AHEPTYFTVDCTEAGQGDVSIGIKCAPGVVGPTEADIDFDIIRNDNDTFTVKYTPRGAGS 845

Query: 1713 YEVSVKFNEEHIPDSPFVVPVASPSGDARRLTVS--SLQESGLKVNQPASFAVSLNGA-K 1883
            Y + V F ++  P SP  V V  PS DA ++      L  +G+++ +P  F ++   A K
Sbjct: 846  YTIMVLFADQATPTSPIRVKV-EPSHDASKVKAEGPGLSRTGVELGKPTHFTINAKAAGK 904

Query: 1884 GAIDAKVH--SPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIR 2057
            G  D +    +   A+ +  + +   + Y V++ P + G   I+V + G  IP SPF + 
Sbjct: 905  GKPDVQFSGLAKGDAVRDVDIIDHHDNTYTVKYTPVQQGPVGINVTYGGDPIPKSPFSVG 964

Query: 2058 VGEPGHGGDPGLVSAYGAGLEGGVTGSPAEFIVNTSNAGA-GALSVTIDGPSKVKMDCQE 2234
            V       D   +   G G +  V G   EF V +  AG  G ++  I GPS   + C+ 
Sbjct: 965  VSP---SLDLSKIKVSGLGEKVDV-GKDQEFTVKSKGAGGQGKVASKITGPSGTAVPCKV 1020

Query: 2235 CP----EGYRVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSVF 2402
             P    +   V + P   G Y + + Y G   + GSPF                      
Sbjct: 1021 EPGLGADNSVVRFVPREEGPYEVEVTYDG-VPVPGSPFP--------------------- 1058

Query: 2403 VDSLTKTXXXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKAGNNMLLVGV 2582
            V++L  T                SKV A G GL     G    FT+D   AG   L + V
Sbjct: 1059 VEALPPT--------------KPSKVKAFGPGLQGGSAGSPARFTIDTKGAGMGGLGLTV 1104

Query: 2583 HGPRTPCE-EILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLV 2738
             G   PCE ++     G    SVSY+  + G+Y + + + D HIPGSP++  V
Sbjct: 1105 EG---PCEAQLECLDNGDGTCSVSYVPTEPGDYNINILFADTHIPGSPFKAHV 1154



 Score =  265 bits (677), Expect = 2e-70
 Identities = 143/349 (40%), Positives = 208/349 (59%), Gaps = 14/349 (4%)
 Frame = +3

Query: 207  EITGEVRMPSGKVAQPAITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFYVDY 386
            ++T +V  PSGK  +  I + ++ T  +R+ P+E G+H + ++Y   H+PGSP QF V  
Sbjct: 2173 DMTAQVTSPSGKTHEAEIVEGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGP 2232

Query: 387  VNCG---HVTAYGPGLSHGVVNKPAVFTVNTKDAGEGGLSLAIEGPSKAEISCTDNQDGT 557
            +  G    V A GPGL       PA F++ T++AG GGL++A+EGPSKAEIS  D +DG+
Sbjct: 2233 LGEGGAHKVRAGGPGLERAEAGVPAEFSIWTREAGAGGLAIAVEGPSKAEISFEDRKDGS 2292

Query: 558  CSVSYLPVLPGDYSILVKYNEQHIPGSPFTARV---TGD------DSMRMSHLKVGSAAD 710
            C V+Y+   PGDY + VK+NE+HIP SPF   V   +GD       S++ S LKV   A 
Sbjct: 2293 CGVAYVVQEPGDYEVSVKFNEEHIPDSPFVVPVASPSGDARRLTVSSLQESGLKVNQPAS 2352

Query: 711  IPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNGQHV 890
              ++++      + A V  PSG  E C +  +      + F+P+E G +L+ VK NG H+
Sbjct: 2353 FAVSLNGAK-GAIDAKVHSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHI 2411

Query: 891  ASSPIPVVISQ-SEIGDASRVRVSGRGLHEGHTFEPAEFIIDTRDAGYGGLSLSIEGPSK 1067
              SP  + + +    GD   V   G GL  G T  PAEFI++T +AG G LS++I+GPSK
Sbjct: 2412 PGSPFKIRVGEPGHGGDPGLVSAYGAGLEGGVTGSPAEFIVNTSNAGAGALSVTIDGPSK 2471

Query: 1068 VDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQ-HVPGSPFSVKVTGE 1211
            V ++ ++  +G  RVTY P  PG+Y+I+IK+    H+ GSPF  KVTGE
Sbjct: 2472 VKMDCQECPEGY-RVTYTPMAPGSYLISIKYGGPYHIGGSPFKAKVTGE 2519



 Score =  252 bits (643), Expect = 2e-66
 Identities = 240/902 (26%), Positives = 380/902 (42%), Gaps = 62/902 (6%)
 Frame = +3

Query: 219  EVRMPSGKVAQPAITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFYV-DYVNC 395
            +V+ P G V    + DN DGT TV Y PS  G + + + Y    +P SP +  V    + 
Sbjct: 1486 KVQGPKGLVEPVDVVDNADGTQTVNYVPSREGPYSISVLYGEEEVPRSPFKVKVLPTHDA 1545

Query: 396  GHVTAYGPGLSHGVV--NKPAVFTVNTKDAGEGGLSLAI---EG-PSKAEISCTDNQDGT 557
              V A GPGL+   V  + P  FT++ KDAGEG L++ I   EG P K  I   DN DGT
Sbjct: 1546 SKVKASGPGLNTTGVPASLPVEFTIDAKDAGEGLLAVQITDPEGKPKKTHIQ--DNHDGT 1603

Query: 558  CSVSYLPVLPGDYSILVKYNEQHIPGSPFTARV--TGDDSMRM---------------SH 686
             +V+Y+P + G Y+IL+KY    IP SP+  R   TGD S                    
Sbjct: 1604 YTVAYVPDVTGRYTILIKYGGDEIPFSPYRVRAVPTGDASKCTVTVSIGGHGLGAGIGPT 1663

Query: 687  LKVGSAADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVH 866
            +++G    I ++        +T TV  P G E    +    +G   I +   + G++++ 
Sbjct: 1664 IQIGEETVITVDTKAAGKGKVTCTVCTPDGSEVDVDVVENEDGTFDIFYTAPQPGKYVIC 1723

Query: 867  VKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEGHTFEPA---EFIIDTRDAGYGG 1037
            V+  G+HV +SP  V     +   A++  +  + L   +T+       +  +    G  G
Sbjct: 1724 VRFGGEHVPNSPFQVTALAGD-QPAAQPPLRPQQLAPPYTYAQGGQQTWAPERPLMGVNG 1782

Query: 1038 LSLSIEGP---------SKVDINTE--------------DLEDGTCRVTYCPTEPGNYII 1148
            L ++   P          K +I  E              D +DGT  V Y P+E G + +
Sbjct: 1783 LDVTSLRPFDLVIPFTIKKGEITGEVRMPSGKVAQPAITDNKDGTVTVRYAPSEAGLHEM 1842

Query: 1149 NIKFADQHVPGSP--FSVKVTGEGRVKESITRRQRAPSVAN--VGSHCDLSLKIPEISIQ 1316
            +I++ + H+PGSP  F V     G V          P + +  V      ++   +    
Sbjct: 1843 DIRYDNMHIPGSPLQFYVDYVNCGHVTAY------GPGLTHGVVNKPAVFTVNTKDAGEG 1896

Query: 1317 DMTAQVTSPSGKSHEAEIVEGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGP 1496
             ++  +  PS    E    + ++ T  + ++P   G +++ VKY  QH+PGSPF   V  
Sbjct: 1897 GLSLAIEGPS--KAEISCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARVT- 1953

Query: 1497 LGEGGAHKVRAGGPGLERAEAGVPAEFSIWTREAGAGGLAIAVEGPSKAE--ISFEDRKD 1670
                G   +R     +   + G  A+  I   E     L   V  PS  E     +  ++
Sbjct: 1954 ----GDDSMR-----MSHLKVGSAADIPINISETDLSLLTATVVPPSGREEPCLLKRLRN 2004

Query: 1671 GSCGVAYVVQEPGDYEVSVKFNEEHIPDSPFVVPVA-SPSGDARRLTVSSLQESGLKVNQ 1847
            G  G+++V +E G++ V VK N +H+  SP  V ++ S  GDA R+ VS          +
Sbjct: 2005 GHVGISFVPKETGEHLVHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGQGLHEGHTFE 2064

Query: 1848 PASFAVSLNGAK-GAIDAKVHSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNG 2024
            PA F +    A  G +   +  PS    +    +++     V + P E G Y+I++KF  
Sbjct: 2065 PAEFIIDTRDAGYGGLSLSIEGPSKV--DINTEDLEDGTCRVTYCPTEPGNYIINIKFAD 2122

Query: 2025 THIPGSPFKIRVGEPGHGGDPGLVSAYGAGLEGGVTGSPAEFIVNTSNAGAGALSVTIDG 2204
             H+PGSPF ++V   G G     ++           GS     +         ++  +  
Sbjct: 2123 QHVPGSPFSVKV--TGEGRVKESITRRRRAPSVANVGSHCNLSLKIPEISIQDMTAQVTS 2180

Query: 2205 PSKVKMDCQECPEG----YRVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSN 2372
            PS  K    E  EG    Y + + P   G + +S+KY G  H+ GSPF+  V        
Sbjct: 2181 PSG-KTHEAEIVEGENHTYCIRFVPAEMGMHTVSVKYKGQ-HVPGSPFQFTVGPLGEGGA 2238

Query: 2373 HSLHETSSVFVDSLTKTXXXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSK 2552
            H                                 KV A G GL +A  G    F++   +
Sbjct: 2239 H---------------------------------KVRAGGPGLERAEAGVPAEFSIWTRE 2265

Query: 2553 AGNNMLLVGVHGPRTPCEEILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRV 2732
            AG   L + V GP     EI  +        V+Y++++ G+Y + VK+ +EHIP SP+ V
Sbjct: 2266 AGAGGLAIAVEGPSKA--EISFEDRKDGSCGVAYVVQEPGDYEVSVKFNEEHIPDSPFVV 2323

Query: 2733 LV 2738
             V
Sbjct: 2324 PV 2325



 Score =  226 bits (577), Expect = 8e-59
 Identities = 230/843 (27%), Positives = 366/843 (43%), Gaps = 50/843 (5%)
 Frame = +3

Query: 354  PGSPLQFYVDYVNCGHVTAYGPGL--SHGVVNKPAVFTVNTKDAGEGGLSLAIEGPS--- 518
            PG+PL+     +N     AYGPG+  +  +V K A FTV T+ AG+G + + +E P+   
Sbjct: 271  PGAPLR---PKLNPKKARAYGPGIEPTGNMVKKRAEFTVETRSAGQGEVLVYVEDPAGHQ 327

Query: 519  -KAEISCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARV--TGDDSMRMSHL 689
             +A+++  ++++ T SV Y+P + G + + V +  QHI  SPF   V  +  D+ +++  
Sbjct: 328  EEAKVTANNDKNRTFSVWYVPEVTGTHKVTVLFAGQHIAKSPFEVYVDKSQGDASKVTAQ 387

Query: 690  KVGSAADIPINISETDLSLLTA---------TVVPPSGRE---EPCLLKRLRNGHVGISF 833
              G      I    T   + TA          +  P+G++   EP L  R  +     S+
Sbjct: 388  GPGLEPSGNIANKTTYFEIFTAGAGTGEVEVVIQDPTGQKGTVEPQLEAR-GDSTYRCSY 446

Query: 834  VPKETGEHLVHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEG--HTFEPAEFI 1007
             P   G H VHV   G  +  SP  V + Q+   +    R  GRGL        E A+F 
Sbjct: 447  QPTMEGVHTVHVTFAGVPIPRSPYTVTVGQA--CNPGACRAVGRGLQPKGVRVKETADFK 504

Query: 1008 IDTRDAGYGGLSLSIEGPSKVD-INTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGS 1184
            + T+ AG G L ++++GP   + +  +DL DG     Y P  PG Y + I +  Q++  S
Sbjct: 505  VYTKGAGSGDLKVTVKGPKGEERVKQKDLGDGVYGFEYYPMVPGTYTVTITWGGQNIGRS 564

Query: 1185 PFSVKVTGE-GRVKESITRRQRAPSVAN--VGSHCDLSLKIPEISIQDMTAQVTSPSGKS 1355
            PF VKV  E G  K     R   P +    VG   D  ++     +  +   V  PS   
Sbjct: 565  PFEVKVGTECGNQKV----RAWGPGLEGGVVGKSADFVVEAIGDDVGTLGFSVEGPSQAK 620

Query: 1356 HEAEIVEGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEG-GAHKVRAG 1532
             E +  +  + +  +R+ P E G + V V    + +  SPF   +    +     +V+A 
Sbjct: 621  IECD--DKGDGSCDVRYWPQEAGEYAVHVLCNSEDIRLSPFMADIREAPQDFHPDRVKAR 678

Query: 1533 GPGLERAEAGV--PAEFSIWTREAGAGGLAIAVEGPS--KAEISFEDRKDGSCGVAYVVQ 1700
            GPGLE+    V  PAEF++  +  G   L + V+       + + +D  +G+   +YV +
Sbjct: 679  GPGLEKTGVAVNKPAEFTVDAKHGGKAALRVQVQDNEGCPVDATVKDNGNGTYSCSYVPR 738

Query: 1701 EPGDYEVSVKFNEEHIPDSPFVVPVASPSGDAR-RLTVSSLQESGLKVNQPASFAVSLNG 1877
            +P  +   V +    IP+SPF V V + S   + ++    + ++GLK ++P  F V    
Sbjct: 739  KPVKHTAMVSWGGVSIPNSPFRVNVGAGSHPNKVKVYGPGVAKTGLKAHEPTYFTVDCTE 798

Query: 1878 A-KGAIDAKVH------SPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIP 2036
            A +G +   +        P+ A  +  +   D D + V++ PR  G Y I V F     P
Sbjct: 799  AGQGDVSIGIKCAPGVVGPTEADIDFDIIRNDNDTFTVKYTPRGAGSYTIMVLFADQATP 858

Query: 2037 GSPFKIRVGEPGHGGDPGLVSAYGAGLE--GGVTGSPAEFIVNTSNAGAGALSVTIDGPS 2210
             SP +++V EP H  D   V A G GL   G   G P  F +N   AG G   V   G +
Sbjct: 859  TSPIRVKV-EPSH--DASKVKAEGPGLSRTGVELGKPTHFTINAKAAGKGKPDVQFSGLA 915

Query: 2211 K----VKMDCQECPEG-YRVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNH 2375
            K      +D  +  +  Y V YTP+  G   I++ YGG   I  SPF   V+        
Sbjct: 916  KGDAVRDVDIIDHHDNTYTVKYTPVQQGPVGINVTYGGD-PIPKSPFSVGVS-------- 966

Query: 2376 SLHETSSVFVDSLTKTXXXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKA 2555
                                            SK+   GLG  K  VG+   FTV    A
Sbjct: 967  ---------------------------PSLDLSKIKVSGLG-EKVDVGKDQEFTVKSKGA 998

Query: 2556 GNN----MLLVGVHGPRTPCEEILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSP 2723
            G        + G  G   PC+  +   +G+    V ++ +++G Y + V +    +PGSP
Sbjct: 999  GGQGKVASKITGPSGTAVPCK--VEPGLGADNSVVRFVPREEGPYEVEVTYDGVPVPGSP 1056

Query: 2724 YRV 2732
            + V
Sbjct: 1057 FPV 1059


>ref|XP_858348.1| PREDICTED: similar to Filamin C (Gamma-filamin) (Filamin 2) (Protein
            FLNc) (Actin-binding-like protein) (ABP-L) (ABP-280-like
            protein) isoform 13 [Canis familiaris].
          Length = 2631

 Score = 1360 bits (3519), Expect = 0.0
 Identities = 649/880 (73%), Positives = 764/880 (86%), Gaps = 3/880 (0%)
 Frame = +3

Query: 111  WAPERPLVGVNGLDVTSLRPFDLVIPFTIKKGEITGEVRMPSGKVAQPAITDNKDGTVTV 290
            WA E P+V    ++ + LRPF+LVIPFT++KGE+TGEVRMPSGK A+P ITDNKDGT+TV
Sbjct: 1753 WATEEPVVPAEPME-SMLRPFNLVIPFTVQKGELTGEVRMPSGKTARPNITDNKDGTITV 1811

Query: 291  RYAPSEAGLHEMDIRYDNMHIPGSPLQFYVDYVNCGHVTAYGPGLSHGVVNKPAVFTVNT 470
            RYAP+E GLH+M I+YD  HIPGSPLQFYVD +N  HV+AYGPGLSHG+VNKPA FT+ T
Sbjct: 1812 RYAPTEKGLHQMGIKYDGNHIPGSPLQFYVDAINSRHVSAYGPGLSHGMVNKPATFTIVT 1871

Query: 471  KDAGEGGLSLAIEGPSKAEISCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTA 650
            KDAGEGGLSLA+EGPSKAEI+C DN+DGTC+VSYLP  PGDYSI+V+++++HIPGSPFTA
Sbjct: 1872 KDAGEGGLSLAVEGPSKAEITCKDNKDGTCTVSYLPTAPGDYSIIVRFDDKHIPGSPFTA 1931

Query: 651  RVTGDDSMRMSHLKVGSAADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGIS 830
            ++TGDDSMR S L VG++ D+ + I+E+DLSLLTA++  PSG EEPCLLKRL N H+GIS
Sbjct: 1932 KITGDDSMRTSQLNVGTSTDVSLKITESDLSLLTASIRAPSGNEEPCLLKRLPNRHIGIS 1991

Query: 831  FVPKETGEHLVHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEGHTFEPAEFII 1010
            F PKE GEH+V V+K+G+HV +SP  +++  SEIGDAS+VRV G+GL EGHTF+ AEFI+
Sbjct: 1992 FTPKEVGEHVVSVRKSGKHVTNSPFKILVGPSEIGDASKVRVWGKGLSEGHTFQVAEFIV 2051

Query: 1011 DTRDAGYGGLSLSIEGPSKVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPF 1190
            DTR+AGYGGL LSIEGPSKVDIN ED+EDGTC+VTYCPTEPG YIINIKFAD+HVPGSPF
Sbjct: 2052 DTRNAGYGGLGLSIEGPSKVDINCEDMEDGTCKVTYCPTEPGTYIINIKFADKHVPGSPF 2111

Query: 1191 SVKVTGEGRVKESITRRQRAPSVANVGSHCDLSLKIP-EISIQDMTAQVTSPSGKSHEAE 1367
            +VKVTGEGR+KESITRR++APS+A +GS CDL+LKIP E S QDMTAQVTSPSGK   AE
Sbjct: 2112 TVKVTGEGRMKESITRRRQAPSIATIGSTCDLNLKIPGEASSQDMTAQVTSPSGKMEAAE 2171

Query: 1368 IVEGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLE 1547
            IVEGE+  Y +RFVP EMG HTV+VKY+GQHVPGSPFQFTVGPLGEGGAHKVRAGG GLE
Sbjct: 2172 IVEGEDSAYSVRFVPQEMGPHTVTVKYRGQHVPGSPFQFTVGPLGEGGAHKVRAGGTGLE 2231

Query: 1548 RAEAGVPAEFSIWTREAGAGGLAIAVEGPSKAEISFEDRKDGSCGVAYVVQEPGDYEVSV 1727
            R  AGVPAEFSIWTREAGAGGL+IAVEGPSKAEI+FEDRKDGSCGV+YVVQEPGDYEVS+
Sbjct: 2232 RGVAGVPAEFSIWTREAGAGGLSIAVEGPSKAEIAFEDRKDGSCGVSYVVQEPGDYEVSI 2291

Query: 1728 KFNEEHIPDSPFVVPVASPSGDARRLTVSSLQESGLKVNQPASFAVSLNGAKGAIDAKVH 1907
            KFN+EHIPDSPFVVPVAS S DARRLTV+SLQE+GLKVNQPASFAV LNGA+G IDA+VH
Sbjct: 2292 KFNDEHIPDSPFVVPVASLSDDARRLTVTSLQETGLKVNQPASFAVQLNGARGVIDARVH 2351

Query: 1908 SPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDP 2087
            +PSGA+EECYV+E+D DK+ +RFIP ENGV+ IDVKFNG HIPGSPFKIRVGE    GDP
Sbjct: 2352 TPSGAVEECYVSELDSDKHTIRFIPHENGVHSIDVKFNGAHIPGSPFKIRVGEQSQAGDP 2411

Query: 2088 GLVSAYGAGLEGGVTGSPAEFIVNTSNAGAGALSVTIDGPSKVKMDCQECPEGYRVTYTP 2267
            GLVSAYG GLEGG TG  +EFIVNT NAG+GALSVTIDGPSKV++DC+ECPEG+ VTYTP
Sbjct: 2412 GLVSAYGPGLEGGTTGVSSEFIVNTLNAGSGALSVTIDGPSKVQLDCRECPEGHVVTYTP 2471

Query: 2268 MAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSVFVDSLTK--TXXXXXX 2441
            MAPG+YLI+IKYGGP HI GSPFKA+VTG RL   HSLHETS+V V+++TK  +      
Sbjct: 2472 MAPGNYLIAIKYGGPQHIVGSPFKAKVTGPRLSGGHSLHETSTVLVETVTKSSSSRGSSY 2531

Query: 2442 XXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKAGNNMLLVGVHGPRTPCEEILVK 2621
                      SKV+ +G GLS+A+VGQK SFTVDCSKAG NM++VGVHGP+TPCEE+ VK
Sbjct: 2532 SSIPKFSSDASKVVTRGPGLSQAFVGQKNSFTVDCSKAGTNMMMVGVHGPKTPCEEVYVK 2591

Query: 2622 HVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLVP 2741
            H+G+R+Y+V+Y +K+KG+Y L+VKWGDE +PGSP++V VP
Sbjct: 2592 HMGNRVYNVTYTVKEKGDYILIVKWGDESVPGSPFKVNVP 2631



 Score =  472 bits (1215), Expect = e-133
 Identities = 313/909 (34%), Positives = 456/909 (50%), Gaps = 44/909 (4%)
 Frame = +3

Query: 144  GLDVTSLRPFDLVIPFTIK-----KGEITGEVRMPSGKVAQPAITDNKDGTVTVRYAPSE 308
            GL+ + + P  L + FTI      +G +T ++  P GK  +  I DN DGT TV Y P  
Sbjct: 1549 GLNASGI-PASLPVEFTIDARDAGEGLLTVQILDPEGKPKKANIRDNGDGTYTVSYLPDM 1607

Query: 309  AGLHEMDIRYDNMHIPGSPLQFYV----DYVNCGHVTA-YGPGLSHGVVNKPAVFTVNTK 473
            +G + + I+Y    IP SP + +     D   C    A  GP +    + +  V TV+ K
Sbjct: 1608 SGRYTITIKYGGDEIPYSPFRIHALPTGDASKCLVTGACLGPRIQ---IGEETVITVDAK 1664

Query: 474  DAGEGGLSLAIEGPSKAE--ISCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFT 647
             AG+G ++  +  P  AE  +   +N DGT  + Y    PG Y I +++  +HIP SPF 
Sbjct: 1665 AAGKGKVTCTVSTPDGAELDVDVVENHDGTFDIYYTAPEPGKYVITIRFGGEHIPNSPF- 1723

Query: 648  ARVTGDDSM-------------RMSHLKVGSAADIPINISETDLSL-------------- 746
              V   D M             R S      A + P+  +E   S+              
Sbjct: 1724 -HVLACDPMPHVEEPADVLQLPRPSTYPTHWATEEPVVPAEPMESMLRPFNLVIPFTVQK 1782

Query: 747  --LTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNGQHVASSPIPVVIS 920
              LT  V  PSG+     +   ++G + + + P E G H + +K +G H+  SP+   + 
Sbjct: 1783 GELTGEVRMPSGKTARPNITDNKDGTITVRYAPTEKGLHQMGIKYDGNHIPGSPLQFYV- 1841

Query: 921  QSEIGDASRVRVSGRGLHEGHTFEPAEFIIDTRDAGYGGLSLSIEGPSKVDINTEDLEDG 1100
              +  ++  V   G GL  G   +PA F I T+DAG GGLSL++EGPSK +I  +D +DG
Sbjct: 1842 --DAINSRHVSAYGPGLSHGMVNKPATFTIVTKDAGEGGLSLAVEGPSKAEITCKDNKDG 1899

Query: 1101 TCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTGEGRVKESITRRQRAPSVANVGSHC 1280
            TC V+Y PT PG+Y I ++F D+H+PGSPF+ K+TG+  ++          S  NVG+  
Sbjct: 1900 TCTVSYLPTAPGDYSIIVRFDDKHIPGSPFTAKITGDDSMR---------TSQLNVGTST 1950

Query: 1281 DLSLKIPEISIQDMTAQVTSPSGKSHEAEIVEGENHTYCIRFVPAEMGMHTVSVKYKGQH 1460
            D+SLKI E  +  +TA + +PSG      +    N    I F P E+G H VSV+  G+H
Sbjct: 1951 DVSLKITESDLSLLTASIRAPSGNEEPCLLKRLPNRHIGISFTPKEVGEHVVSVRKSGKH 2010

Query: 1461 VPGSPFQFTVGPLGEGGAHKVRAGGPGLERAEAGVPAEFSIWTREAGAGGLAIAVEGPSK 1640
            V  SPF+  VGP   G A KVR  G GL        AEF + TR AG GGL +++EGPSK
Sbjct: 2011 VTNSPFKILVGPSEIGDASKVRVWGKGLSEGHTFQVAEFIVDTRNAGYGGLGLSIEGPSK 2070

Query: 1641 AEISFEDRKDGSCGVAYVVQEPGDYEVSVKFNEEHIPDSPFVVPVASPSGDARRLTVSSL 1820
             +I+ ED +DG+C V Y   EPG Y +++KF ++H+P SPF V V         +T    
Sbjct: 2071 VDINCEDMEDGTCKVTYCPTEPGTYIINIKFADKHVPGSPFTVKVTGEGRMKESITRRRQ 2130

Query: 1821 QESGLKVNQPASFAVSLNGAKGAID--AKVHSPSGALEECYVTEIDQDKYAVRFIPRENG 1994
              S   +       + + G   + D  A+V SPSG +E   + E +   Y+VRF+P+E G
Sbjct: 2131 APSIATIGSTCDLNLKIPGEASSQDMTAQVTSPSGKMEAAEIVEGEDSAYSVRFVPQEMG 2190

Query: 1995 VYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPGLVSAYGAGLEGGVTGSPAEFIVNTSNAG 2174
             + + VK+ G H+PGSPF+  VG  G GG    V A G GLE GV G PAEF + T  AG
Sbjct: 2191 PHTVTVKYRGQHVPGSPFQFTVGPLGEGG-AHKVRAGGTGLERGVAGVPAEFSIWTREAG 2249

Query: 2175 AGALSVTIDGPSKVKMDCQECPEG-YRVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVT 2351
            AG LS+ ++GPSK ++  ++  +G   V+Y    PG Y +SIK+    HI  SPF   V 
Sbjct: 2250 AGGLSIAVEGPSKAEIAFEDRKDGSCGVSYVVQEPGDYEVSIKFNDE-HIPDSPFVVPVA 2308

Query: 2352 GHRLVSNHSLHETSSVFVDSLTKTXXXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGS 2531
                +S+ +   T    V SL +T                        GL    V Q  S
Sbjct: 2309 S---LSDDARRLT----VTSLQET------------------------GLK---VNQPAS 2334

Query: 2532 FTVDCSKAGNNMLLVGVHGPRTPCEEILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHI 2711
            F V  + A   ++   VH P    EE  V  + S  +++ ++  + G +++ VK+   HI
Sbjct: 2335 FAVQLNGA-RGVIDARVHTPSGAVEECYVSELDSDKHTIRFIPHENGVHSIDVKFNGAHI 2393

Query: 2712 PGSPYRVLV 2738
            PGSP+++ V
Sbjct: 2394 PGSPFKIRV 2402



 Score =  321 bits (823), Expect = 2e-87
 Identities = 244/892 (27%), Positives = 401/892 (44%), Gaps = 46/892 (5%)
 Frame = +3

Query: 201  KGEITGEVRMPSGKVAQPAITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFYV 380
            + E+T E+   +G  A+  I +N DGT  + Y+P+  G + + I+Y    +P  P + +V
Sbjct: 1186 EAELTIEILSDAGVKAEVLIHNNADGTYHITYSPAFPGTYTITIKYGGHPVPKFPTRVHV 1245

Query: 381  D-YVNCGHVTAYGPGLS-HGVVNKPAV-FTVNTKD---AGEGGLSLAIEGPS--KAEISC 536
               V+   +   GPG+  HGV+ +    FTV+ +     G   ++  +  PS  K +   
Sbjct: 1246 QPAVDTSGIKVSGPGVEPHGVLREVTTEFTVDARSLTATGGNHVTARVLNPSGAKTDTYV 1305

Query: 537  TDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARVT-GDDSMRMSHL-------K 692
            TDN DGT  V Y     G + + V Y++  +P SPF   VT G D  R+           
Sbjct: 1306 TDNGDGTYRVQYTAYEEGVHLVEVLYDDVAVPKSPFRVGVTEGCDPTRVRAFGPGLESGL 1365

Query: 693  VGSAADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVK 872
            V  A    +         L   +  PS  +  C  K  ++G   + ++P   G++ V++ 
Sbjct: 1366 VNKANHFTVETRGAGTGGLGLAIEGPSEAKMSC--KDNKDGSCTVEYIPFTPGDYDVNIT 1423

Query: 873  KNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEG-HTFEPAEFIIDTRDAGYGGLSLS 1049
              G+ +  SP  V +   ++ D  +V+ SG GL  G     P  F +D   AG   L ++
Sbjct: 1424 FGGRPIPGSPFRVPV--KDVVDPGKVKCSGPGLGAGVRARVPQTFTVDCSQAGRAPLQVA 1481

Query: 1050 IEGPSKVDINTEDLED--GTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTGEGRVK 1223
            + GP+ V    E L++  GT  V Y P   G Y + +K+ADQ VP SPF +KV       
Sbjct: 1482 VLGPTGVAEPVEVLDNGGGTHTVHYTPATDGPYTVAVKYADQEVPRSPFKIKVL---PAH 1538

Query: 1224 ESITRRQRAPSVANVGSHCDLSLKIPEISIQD-----MTAQVTSPSGKSHEAEIVEGENH 1388
            ++   R   P +   G    L ++   I  +D     +T Q+  P GK  +A I +  + 
Sbjct: 1539 DASKVRASGPGLNASGIPASLPVEF-TIDARDAGEGLLTVQILDPEGKPKKANIRDNGDG 1597

Query: 1389 TYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLERAEAGVP 1568
            TY + ++P   G +T+++KY G  +P SPF+    P G+     V     G  R + G  
Sbjct: 1598 TYTVSYLPDMSGRYTITIKYGGDEIPYSPFRIHALPTGDASKCLVTGACLG-PRIQIGEE 1656

Query: 1569 AEFSIWTREAGAGGLAIAVEGPSKAEISFE--DRKDGSCGVAYVVQEPGDYEVSVKFNEE 1742
               ++  + AG G +   V  P  AE+  +  +  DG+  + Y   EPG Y ++++F  E
Sbjct: 1657 TVITVDAKAAGKGKVTCTVSTPDGAELDVDVVENHDGTFDIYYTAPEPGKYVITIRFGGE 1716

Query: 1743 HIPDSPFVVPVASP------SGDARRLTVSSLQESGLKVNQPA-------------SFAV 1865
            HIP+SPF V    P        D  +L   S   +     +P              +  +
Sbjct: 1717 HIPNSPFHVLACDPMPHVEEPADVLQLPRPSTYPTHWATEEPVVPAEPMESMLRPFNLVI 1776

Query: 1866 SLNGAKGAIDAKVHSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSP 2045
                 KG +  +V  PSG      +T+       VR+ P E G++ + +K++G HIPGSP
Sbjct: 1777 PFTVQKGELTGEVRMPSGKTARPNITDNKDGTITVRYAPTEKGLHQMGIKYDGNHIPGSP 1836

Query: 2046 FKIRVGEPGHGGDPGLVSAYGAGLEGGVTGSPAEFIVNTSNAGAGALSVTIDGPSKVKMD 2225
             +  V       +   VSAYG GL  G+   PA F + T +AG G LS+ ++GPSK ++ 
Sbjct: 1837 LQFYV----DAINSRHVSAYGPGLSHGMVNKPATFTIVTKDAGEGGLSLAVEGPSKAEIT 1892

Query: 2226 CQECPEG-YRVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSVF 2402
            C++  +G   V+Y P APG Y I +++    HI GSPF A++TG                
Sbjct: 1893 CKDNKDGTCTVSYLPTAPGDYSIIVRFDDK-HIPGSPFTAKITG---------------- 1935

Query: 2403 VDSLTKTXXXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKAGNNMLLVGV 2582
             D   +T                          S+  VG     ++  +++  ++L   +
Sbjct: 1936 -DDSMRT--------------------------SQLNVGTSTDVSLKITESDLSLLTASI 1968

Query: 2583 HGPRTPCEEILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLV 2738
              P    E  L+K + +R   +S+  K+ GE+ + V+   +H+  SP+++LV
Sbjct: 1969 RAPSGNEEPCLLKRLPNRHIGISFTPKEVGEHVVSVRKSGKHVTNSPFKILV 2020



 Score =  307 bits (787), Expect = 3e-83
 Identities = 268/894 (29%), Positives = 406/894 (45%), Gaps = 48/894 (5%)
 Frame = +3

Query: 201  KGEITGEVRMPSGKVAQPAITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFYV 380
            KG++    +   G      +  N DGT    Y P++   H + I +  +++P SP +  V
Sbjct: 700  KGDLNLYAQDADGCPVNIMVIPNGDGTFRCSYVPTKPIKHTIIISWGGVNVPKSPFRVNV 759

Query: 381  -DYVNCGHVTAYGPGLSHG--VVNKPAVFTVNTKDAGEGGLSLAIE------GPSKAEI- 530
             +  +   V  YGPG+       N+P  FTV+  +AG+G +S+ I+      GP++A+I 
Sbjct: 760  GEGSHPERVKVYGPGVEKTGLKANEPTYFTVDCSEAGQGDVSIGIKCAPGVVGPAEADID 819

Query: 531  -SCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARVTGDDSMRMSHLKVGSAA 707
                 N + T +V Y P   G Y+I+V +  Q IP SPF  +V  D S   S +K   A 
Sbjct: 820  FDIIKNDNDTFTVKYTPPGAGRYTIMVLFANQEIPASPFHIKV--DPSHDASKVK---AE 874

Query: 708  DIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVG-----------------ISFV 836
               +N +  ++   T   V   G  +  L         G                 + + 
Sbjct: 875  GPGLNRTGVEVGKPTHFTVLTKGAGKAKLDVHFAGAAKGEAVRDFEIIDNHDYSYTVKYT 934

Query: 837  PKETGEHLVHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEGHTFEPAEFIIDT 1016
              + G   V V   G  V  SP   V++ +   D S+V+V G         E A F ++T
Sbjct: 935  AVQQGNMAVTVTYGGDPVPKSPF--VVNVAPPLDLSKVKVQGLNSKVAVGQEQA-FSVNT 991

Query: 1017 RDA-GYGGLSLSIEGPSKVDINTEDLEDG----TCRVTYCPTEPGNYIINIKFADQHVPG 1181
            R A G G L + +  PS+  I  + +E G    T  V Y P E G Y ++I +    VPG
Sbjct: 992  RGAGGQGQLDVRMTSPSRRPIPCK-VEPGGGAETQAVRYMPPEEGPYKVDITYDGHPVPG 1050

Query: 1182 SPFSVKVTGEGRVKESITR-RQRAPSVAN--VGSHCDLSLKIPEISIQDMTAQVTSPSGK 1352
            SPF+V    EG +    ++     P +    VGS    S+         +   V  P   
Sbjct: 1051 SPFAV----EGVLPPDPSKVCAYGPGLKGGLVGSPAPFSIDTKGAGTGGLGLTVEGPCEA 1106

Query: 1353 SHEAEIVEGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAG 1532
              E +  +  + +  + ++P E G +T+++ +   H+PGSPF+ T+ P+ +    KVRA 
Sbjct: 1107 KIECQ--DNGDGSCAVSYLPTEPGEYTINILFAEAHIPGSPFKATIRPVFD--PSKVRAS 1162

Query: 1533 GPGLERAEAGVPAEFSIWTREAGAGGLAIAV--EGPSKAEISFEDRKDGSCGVAYVVQEP 1706
            GPGLER +AG  A F++   EAG   L I +  +   KAE+   +  DG+  + Y    P
Sbjct: 1163 GPGLERGKAGEAATFTVDCSEAGEAELTIEILSDAGVKAEVLIHNNADGTYHITYSPAFP 1222

Query: 1707 GDYEVSVKFNEEHIPDSPFVVPVASPSGDARRLTVS--SLQESGLKVNQPASFAV---SL 1871
            G Y +++K+    +P  P  V V  P+ D   + VS   ++  G+       F V   SL
Sbjct: 1223 GTYTITIKYGGHPVPKFPTRVHV-QPAVDTSGIKVSGPGVEPHGVLREVTTEFTVDARSL 1281

Query: 1872 NGAKG-AIDAKVHSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPF 2048
                G  + A+V +PSGA  + YVT+     Y V++   E GV+L++V ++   +P SPF
Sbjct: 1282 TATGGNHVTARVLNPSGAKTDTYVTDNGDGTYRVQYTAYEEGVHLVEVLYDDVAVPKSPF 1341

Query: 2049 KIRVGEPGHGGDPGLVSAYGAGLEGGVTGSPAEFIVNTSNAGAGALSVTIDGPSKVKMDC 2228
            ++ V E   G DP  V A+G GLE G+      F V T  AG G L + I+GPS+ KM C
Sbjct: 1342 RVGVTE---GCDPTRVRAFGPGLESGLVNKANHFTVETRGAGTGGLGLAIEGPSEAKMSC 1398

Query: 2229 QECPEG-YRVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSVFV 2405
            ++  +G   V Y P  PG Y ++I +GG   I GSPF+  V                  V
Sbjct: 1399 KDNKDGSCTVEYIPFTPGDYDVNITFGG-RPIPGSPFRVPVKD---------------VV 1442

Query: 2406 DSLTKTXXXXXXXXXXXXXXXXSKVLAKGLGLS---KAYVGQKGSFTVDCSKAGNNMLLV 2576
            D                      KV   G GL    +A V Q  +FTVDCS+AG   L V
Sbjct: 1443 D--------------------PGKVKCSGPGLGAGVRARVPQ--TFTVDCSQAGRAPLQV 1480

Query: 2577 GVHGPRTPCEEILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLV 2738
             V GP    E + V   G   ++V Y     G YT+ VK+ D+ +P SP+++ V
Sbjct: 1481 AVLGPTGVAEPVEVLDNGGGTHTVHYTPATDGPYTVAVKYADQEVPRSPFKIKV 1534



 Score =  297 bits (760), Expect = 5e-80
 Identities = 246/895 (27%), Positives = 381/895 (42%), Gaps = 50/895 (5%)
 Frame = +3

Query: 204  GEITGEVRMPSGKVAQPAITDNKDG--TVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFY 377
            GE+   +  P G   +  +  N D   T  V Y P  AGLH++ + +   +I  SP +  
Sbjct: 309  GEVLVYIEDPEGHTEEAKVVPNNDKNRTYAVSYVPKVAGLHKVTVLFAGQNIERSPFEVN 368

Query: 378  VDYV--NCGHVTAYGPGLSH--GVVNKPAVFTVNTKDAGEGGLSLAIEGPS----KAEIS 533
            V     +   V+A GPGL     V NKP  F + T  AG G +++ I  P       E++
Sbjct: 369  VGMALGDANKVSARGPGLEPMGNVANKPTYFDIYTAGAGTGDVAVVIVDPQGRRDTVEVA 428

Query: 534  CTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARVT----------GDDSMRMS 683
              D  D T   +Y PV+ G +++ V +    I  SPF   V               ++  
Sbjct: 429  LEDKGDNTFRCTYRPVMEGPHTVHVAFAGAPITRSPFPVHVAEACNPNACRASGRGLQPK 488

Query: 684  HLKVGSAADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLV 863
             ++V   AD  +         L  TV  P G EEP  ++   +G     + P   G+++V
Sbjct: 489  GVRVKEVADFKVFTKGAGSGELKVTVKGPKGTEEPVKVREAGDGVFECEYYPVVPGKYVV 548

Query: 864  HVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEGHTFEPAEFIIDTRDAGYGGLS 1043
             +   G  +  SP  V +S        +VR  G GL  G   + A+F+++      G L 
Sbjct: 549  TITWGGYAIPRSPFEVQVSPE--AGTQKVRAWGPGLKTGQVGKSADFVVEAIGTEVGTLG 606

Query: 1044 LSIEGPSKVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTGEGRVK 1223
             SIEGPS+  I  +D  DG+C V Y PTEPG Y +++   D+ +  SPF   +  +    
Sbjct: 607  FSIEGPSQAKIECDDKGDGSCDVRYWPTEPGEYAVHVICDDEDIRDSPFIAHI--QPAAP 664

Query: 1224 ESITRRQRA------PSVANVGSHCDLSLKIPEISIQDMTAQVTSPSGKSHEAEIVEGEN 1385
            +    + +A      P+   V    + ++        D+        G      ++   +
Sbjct: 665  DCFPDKVKAFGPGLEPTGCIVDKPAEFTIDARAAGKGDLNLYAQDADGCPVNIMVIPNGD 724

Query: 1386 HTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAH--KVRAGGPGLERA-- 1553
             T+   +VP +   HT+ + + G +VP SPF+  VG     G+H  +V+  GPG+E+   
Sbjct: 725  GTFRCSYVPTKPIKHTIIISWGGVNVPKSPFRVNVGE----GSHPERVKVYGPGVEKTGL 780

Query: 1554 EAGVPAEFSIWTREAGAGGLAIAVE------GPSKAEISFEDRK--DGSCGVAYVVQEPG 1709
            +A  P  F++   EAG G ++I ++      GP++A+I F+  K  + +  V Y     G
Sbjct: 781  KANEPTYFTVDCSEAGQGDVSIGIKCAPGVVGPAEADIDFDIIKNDNDTFTVKYTPPGAG 840

Query: 1710 DYEVSVKFNEEHIPDSPFVVPVASPSGDARRLTVS--SLQESGLKVNQPASFAVSLNGAK 1883
             Y + V F  + IP SPF + V  PS DA ++      L  +G++V +P  F V   GA 
Sbjct: 841  RYTIMVLFANQEIPASPFHIKV-DPSHDASKVKAEGPGLNRTGVEVGKPTHFTVLTKGA- 898

Query: 1884 GAIDAKVH----SPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFK 2051
            G     VH    +   A+ +  + +     Y V++   + G   + V + G  +P SPF 
Sbjct: 899  GKAKLDVHFAGAAKGEAVRDFEIIDNHDYSYTVKYTAVQQGNMAVTVTYGGDPVPKSPFV 958

Query: 2052 IRVGEPGHGGDPGLVSAYGAGLEGGVTGSPAEFIVNTSNAGA-GALSVTIDGPSKVKMDC 2228
            + V  P    D   V   G   +  V G    F VNT  AG  G L V +  PS+  + C
Sbjct: 959  VNVAPP---LDLSKVKVQGLNSKVAV-GQEQAFSVNTRGAGGQGQLDVRMTSPSRRPIPC 1014

Query: 2229 QECPEG----YRVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSS 2396
            +  P G      V Y P   G Y + I Y G + + GSPF                    
Sbjct: 1015 KVEPGGGAETQAVRYMPPEEGPYKVDITYDG-HPVPGSPFAVE----------------- 1056

Query: 2397 VFVDSLTKTXXXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKAGNNMLLV 2576
                                     SKV A G GL    VG    F++D   AG   L +
Sbjct: 1057 ------------------GVLPPDPSKVCAYGPGLKGGLVGSPAPFSIDTKGAGTGGLGL 1098

Query: 2577 GVHGPRTPCE-EILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLV 2738
             V G   PCE +I  +  G    +VSYL  + GEYT+ + + + HIPGSP++  +
Sbjct: 1099 TVEG---PCEAKIECQDNGDGSCAVSYLPTEPGEYTINILFAEAHIPGSPFKATI 1150



 Score =  276 bits (705), Expect = 1e-73
 Identities = 244/873 (27%), Positives = 375/873 (42%), Gaps = 40/873 (4%)
 Frame = +3

Query: 264  DNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFYVDYV--NC--GHVTAYGPGLSH 431
            D  DG+  VRY P+E G + + +  D+  I  SP   ++     +C    V A+GPGL  
Sbjct: 621  DKGDGSCDVRYWPTEPGEYAVHVICDDEDIRDSPFIAHIQPAAPDCFPDKVKAFGPGLEP 680

Query: 432  G--VVNKPAVFTVNTKDAGEGGLSLAIEGPS--KAEISCTDNQDGTCSVSYLPVLPGDYS 599
               +V+KPA FT++ + AG+G L+L  +        I    N DGT   SY+P  P  ++
Sbjct: 681  TGCIVDKPAEFTIDARAAGKGDLNLYAQDADGCPVNIMVIPNGDGTFRCSYVPTKPIKHT 740

Query: 600  ILVKYNEQHIPGSPFTARVTGDDS-----------MRMSHLKVGSAADIPINISET---D 737
            I++ +   ++P SPF   V G+ S           +  + LK        ++ SE    D
Sbjct: 741  IIISWGGVNVPKSPFRVNV-GEGSHPERVKVYGPGVEKTGLKANEPTYFTVDCSEAGQGD 799

Query: 738  LSL---LTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNGQHVASSPIP 908
            +S+       VV P+  +    + +  N    + + P   G + + V    Q + +SP  
Sbjct: 800  VSIGIKCAPGVVGPAEADIDFDIIKNDNDTFTVKYTPPGAGRYTIMVLFANQEIPASPFH 859

Query: 909  VVISQSEIGDASRVRVSGRGLHEG--HTFEPAEFIIDTRDAGYGGLSLSIEGPSKV---- 1070
            + +  S   DAS+V+  G GL+       +P  F + T+ AG   L +   G +K     
Sbjct: 860  IKVDPSH--DASKVKAEGPGLNRTGVEVGKPTHFTVLTKGAGKAKLDVHFAGAAKGEAVR 917

Query: 1071 DINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTGEGRVKESITRRQRA 1250
            D    D  D +  V Y   + GN  + + +    VP SPF V V     +  S  + Q  
Sbjct: 918  DFEIIDNHDYSYTVKYTAVQQGNMAVTVTYGGDPVPKSPFVVNVAPP--LDLSKVKVQGL 975

Query: 1251 PSVANVGSHCDLSLKIPEISIQ-DMTAQVTSPSGKSHEAEIVEGEN-HTYCIRFVPAEMG 1424
             S   VG     S+       Q  +  ++TSPS +    ++  G    T  +R++P E G
Sbjct: 976  NSKVAVGQEQAFSVNTRGAGGQGQLDVRMTSPSRRPIPCKVEPGGGAETQAVRYMPPEEG 1035

Query: 1425 MHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLERAEAGVPAEFSIWTREAGA 1604
             + V + Y G  VPGSPF   V  +      KV A GPGL+    G PA FSI T+ AG 
Sbjct: 1036 PYKVDITYDGHPVPGSPF--AVEGVLPPDPSKVCAYGPGLKGGLVGSPAPFSIDTKGAGT 1093

Query: 1605 GGLAIAVEGPSKAEISFEDRKDGSCGVAYVVQEPGDYEVSVKFNEEHIPDSPFVVPVASP 1784
            GGL + VEGP +A+I  +D  DGSC V+Y+  EPG+Y +++ F E HIP SPF   +  P
Sbjct: 1094 GGLGLTVEGPCEAKIECQDNGDGSCAVSYLPTEPGEYTINILFAEAHIPGSPFKATI-RP 1152

Query: 1785 SGDARRLTVSSLQESGLKVNQPASFAVSLNGA-KGAIDAKVHSPSGALEECYVTEIDQDK 1961
              D  ++  S       K  + A+F V  + A +  +  ++ S +G   E  +       
Sbjct: 1153 VFDPSKVRASGPGLERGKAGEAATFTVDCSEAGEAELTIEILSDAGVKAEVLIHNNADGT 1212

Query: 1962 YAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPGLVSAYGAGLEGGVTGSP 2141
            Y + + P   G Y I +K+ G  +P  P ++ V +P        VS  G    G +    
Sbjct: 1213 YHITYSPAFPGTYTITIKYGGHPVPKFPTRVHV-QPAVDTSGIKVSGPGVEPHGVLREVT 1271

Query: 2142 AEFIVNTSN---AGAGALSVTIDGPSKVKMDCQECPEG---YRVTYTPMAPGSYLISIKY 2303
             EF V+  +    G   ++  +  PS  K D      G   YRV YT    G +L+ + Y
Sbjct: 1272 TEFTVDARSLTATGGNHVTARVLNPSGAKTDTYVTDNGDGTYRVQYTAYEEGVHLVEVLY 1331

Query: 2304 GGPYHIGGSPFKARVTGHRLVSNHSLHETSSVFVDSLTKTXXXXXXXXXXXXXXXXSKVL 2483
                 +  SPF+  VT                                        ++V 
Sbjct: 1332 -DDVAVPKSPFRVGVT-----------------------------------EGCDPTRVR 1355

Query: 2484 AKGLGLSKAYVGQKGSFTVDCSKAGNNMLLVGVHGPRTPCEEILVKHVGSRLYSVSYLLK 2663
            A G GL    V +   FTV+   AG   L + + GP            GS   +V Y+  
Sbjct: 1356 AFGPGLESGLVNKANHFTVETRGAGTGGLGLAIEGPSEAKMSCKDNKDGS--CTVEYIPF 1413

Query: 2664 DKGEYTLVVKWGDEHIPGSPYRVLVP*ALCPGQ 2762
              G+Y + + +G   IPGSP+RV V   + PG+
Sbjct: 1414 TPGDYDVNITFGGRPIPGSPFRVPVKDVVDPGK 1446



 Score =  232 bits (591), Expect = 2e-60
 Identities = 234/840 (27%), Positives = 368/840 (43%), Gaps = 47/840 (5%)
 Frame = +3

Query: 354  PGSPLQFYVDYVNCGHVTAYGPGLS-HG-VVNKPAVFTVNTKDAGEGGLSLAIEGP---- 515
            PG+P++     +N     AYGPG+  HG  V +PA FTV T DAG G + + IE P    
Sbjct: 265  PGAPVRS--KQLNPKKAIAYGPGIEPHGNTVLQPAHFTVQTVDAGVGEVLVYIEDPEGHT 322

Query: 516  SKAEISCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARV---TGDD---SMR 677
             +A++   ++++ T +VSY+P + G + + V +  Q+I  SPF   V    GD    S R
Sbjct: 323  EEAKVVPNNDKNRTYAVSYVPKVAGLHKVTVLFAGQNIERSPFEVNVGMALGDANKVSAR 382

Query: 678  MSHLK-VGSAADIP----INISETDLSLLTATVVPPSGREE--PCLLKRLRNGHVGISFV 836
               L+ +G+ A+ P    I  +      +   +V P GR +     L+   +     ++ 
Sbjct: 383  GPGLEPMGNVANKPTYFDIYTAGAGTGDVAVVIVDPQGRRDTVEVALEDKGDNTFRCTYR 442

Query: 837  PKETGEHLVHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEG--HTFEPAEFII 1010
            P   G H VHV   G  +  SP PV +  +E  + +  R SGRGL        E A+F +
Sbjct: 443  PVMEGPHTVHVAFAGAPITRSPFPVHV--AEACNPNACRASGRGLQPKGVRVKEVADFKV 500

Query: 1011 DTRDAGYGGLSLSIEGPSKVD--INTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGS 1184
             T+ AG G L ++++GP   +  +   +  DG     Y P  PG Y++ I +    +P S
Sbjct: 501  FTKGAGSGELKVTVKGPKGTEEPVKVREAGDGVFECEYYPVVPGKYVVTITWGGYAIPRS 560

Query: 1185 PFSVKVTGEGRVKESITRRQRAPSV--ANVGSHCDLSLKIPEISIQDMTAQVTSPSGKSH 1358
            PF V+V+ E   ++    R   P +    VG   D  ++     +  +   +  PS    
Sbjct: 561  PFEVQVSPEAGTQKV---RAWGPGLKTGQVGKSADFVVEAIGTEVGTLGFSIEGPSQAKI 617

Query: 1359 EAEIVEGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLG-EGGAHKVRAGG 1535
            E +  +  + +  +R+ P E G + V V    + +  SPF   + P   +    KV+A G
Sbjct: 618  ECD--DKGDGSCDVRYWPTEPGEYAVHVICDDEDIRDSPFIAHIQPAAPDCFPDKVKAFG 675

Query: 1536 PGLERAEAGV--PAEFSIWTREAGAGGLAIAVEGPSKAEISFE--DRKDGSCGVAYVVQE 1703
            PGLE     V  PAEF+I  R AG G L +  +      ++       DG+   +YV  +
Sbjct: 676  PGLEPTGCIVDKPAEFTIDARAAGKGDLNLYAQDADGCPVNIMVIPNGDGTFRCSYVPTK 735

Query: 1704 PGDYEVSVKFNEEHIPDSPFVVPVASPSGDAR-RLTVSSLQESGLKVNQPASFAVSLNGA 1880
            P  + + + +   ++P SPF V V   S   R ++    ++++GLK N+P  F V  + A
Sbjct: 736  PIKHTIIISWGGVNVPKSPFRVNVGEGSHPERVKVYGPGVEKTGLKANEPTYFTVDCSEA 795

Query: 1881 -KGAIDAKVH------SPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPG 2039
             +G +   +        P+ A  +  + + D D + V++ P   G Y I V F    IP 
Sbjct: 796  GQGDVSIGIKCAPGVVGPAEADIDFDIIKNDNDTFTVKYTPPGAGRYTIMVLFANQEIPA 855

Query: 2040 SPFKIRVGEPGHGGDPGLVSAYGAGLE--GGVTGSPAEFIVNTSNAGAGALSVTIDGPSK 2213
            SPF I+V +P H  D   V A G GL   G   G P  F V T  AG   L V   G +K
Sbjct: 856  SPFHIKV-DPSH--DASKVKAEGPGLNRTGVEVGKPTHFTVLTKGAGKAKLDVHFAGAAK 912

Query: 2214 VKM-----DCQECPEGYRVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHS 2378
             +              Y V YT +  G+  +++ YGG   +  SPF   V          
Sbjct: 913  GEAVRDFEIIDNHDYSYTVKYTAVQQGNMAVTVTYGGD-PVPKSPFVVNVA--------- 962

Query: 2379 LHETSSVFVDSLTKTXXXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKA- 2555
                                           SKV  +GL  SK  VGQ+ +F+V+   A 
Sbjct: 963  --------------------------PPLDLSKVKVQGLN-SKVAVGQEQAFSVNTRGAG 995

Query: 2556 GNNMLLVGVHGP-RTPCEEILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRV 2732
            G   L V +  P R P    +    G+   +V Y+  ++G Y + + +    +PGSP+ V
Sbjct: 996  GQGQLDVRMTSPSRRPIPCKVEPGGGAETQAVRYMPPEEGPYKVDITYDGHPVPGSPFAV 1055


  Database: RefSeq49_CP.fasta
    Posted date:  Oct 17, 2011  1:42 PM
  Number of letters in database: 18,874,504
  Number of sequences in database:  33,336
  
Lambda     K      H
   0.318    0.134    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 33336
Number of Hits to DB: 129,897,273
Number of extensions: 4041727
Number of successful extensions: 28684
Number of sequences better than 1.0e-05: 33
Number of HSP's gapped: 22561
Number of HSP's successfully gapped: 502
Length of query: 1029
Length of database: 18,874,504
Length adjustment: 113
Effective length of query: 916
Effective length of database: 15,107,536
Effective search space: 13838502976
Effective search space used: 13838502976
Neighboring words threshold: 12
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 36 (18.5 bits)

BLASTX 2.2.24 [Aug-08-2010]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= 20110601C-007518
         (3088 letters)

Database: RefSeq49_HP.fasta 
           32,964 sequences; 18,297,164 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

Alignment   gi|NP_001104026.1| filamin-A isoform 2 [Homo sapiens].              1758   0.0  
Alignment   gi|NP_001447.2| filamin-A isoform 1 [Homo sapiens].                 1758   0.0  
Alignment   gi|NP_001157789.1| filamin-B isoform 1 [Homo sapiens].              1313   0.0  
Alignment   gi|NP_001448.2| filamin-B isoform 2 [Homo sapiens].                 1313   0.0  
Alignment   gi|NP_001157790.1| filamin-B isoform 3 [Homo sapiens].              1309   0.0  
Alignment   gi|NP_001157791.1| filamin-B isoform 4 [Homo sapiens].              1308   0.0  
Alignment   gi|NP_001120959.1| filamin-C isoform b [Homo sapiens].               797   0.0  
Alignment   gi|NP_001449.3| filamin-C isoform a [Homo sapiens].                  797   0.0  
Alignment   gi|NP_079464.2| tripartite motif-containing protein 45 isoform ...    53   2e-06

>ref|NP_001104026.1| filamin-A isoform 2 [Homo sapiens].
          Length = 2647

 Score = 1758 bits (4554), Expect = 0.0
 Identities = 868/913 (95%), Positives = 879/913 (96%)
 Frame = +3

Query: 3    PFQVTALAGEQPSVXXXXXXXXXXXXYTYAQGGQQTWAPERPLVGVNGLDVTSLRPFDLV 182
            PFQVTALAG+QPSV            YTYAQGGQQTWAPERPLVGVNGLDVTSLRPFDLV
Sbjct: 1735 PFQVTALAGDQPSVQPPLRSQQLAPQYTYAQGGQQTWAPERPLVGVNGLDVTSLRPFDLV 1794

Query: 183  IPFTIKKGEITGEVRMPSGKVAQPAITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGS 362
            IPFTIKKGEITGEVRMPSGKVAQP ITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGS
Sbjct: 1795 IPFTIKKGEITGEVRMPSGKVAQPTITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGS 1854

Query: 363  PLQFYVDYVNCGHVTAYGPGLSHGVVNKPAVFTVNTKDAGEGGLSLAIEGPSKAEISCTD 542
            PLQFYVDYVNCGHVTAYGPGL+HGVVNKPA FTVNTKDAGEGGLSLAIEGPSKAEISCTD
Sbjct: 1855 PLQFYVDYVNCGHVTAYGPGLTHGVVNKPATFTVNTKDAGEGGLSLAIEGPSKAEISCTD 1914

Query: 543  NQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARVTGDDSMRMSHLKVGSAADIPIN 722
            NQDGTCSVSYLPVLPGDYSILVKYNEQH+PGSPFTARVTGDDSMRMSHLKVGSAADIPIN
Sbjct: 1915 NQDGTCSVSYLPVLPGDYSILVKYNEQHVPGSPFTARVTGDDSMRMSHLKVGSAADIPIN 1974

Query: 723  ISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNGQHVASSP 902
            ISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNGQHVASSP
Sbjct: 1975 ISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNGQHVASSP 2034

Query: 903  IPVVISQSEIGDASRVRVSGRGLHEGHTFEPAEFIIDTRDAGYGGLSLSIEGPSKVDINT 1082
            IPVVISQSEIGDASRVRVSG+GLHEGHTFEPAEFIIDTRDAGYGGLSLSIEGPSKVDINT
Sbjct: 2035 IPVVISQSEIGDASRVRVSGQGLHEGHTFEPAEFIIDTRDAGYGGLSLSIEGPSKVDINT 2094

Query: 1083 EDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTGEGRVKESITRRQRAPSVA 1262
            EDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTGEGRVKESITRR+RAPSVA
Sbjct: 2095 EDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTGEGRVKESITRRRRAPSVA 2154

Query: 1263 NVGSHCDLSLKIPEISIQDMTAQVTSPSGKSHEAEIVEGENHTYCIRFVPAEMGMHTVSV 1442
            NVGSHCDLSLKIPEISIQDMTAQVTSPSGK+HEAEIVEGENHTYCIRFVPAEMG HTVSV
Sbjct: 2155 NVGSHCDLSLKIPEISIQDMTAQVTSPSGKTHEAEIVEGENHTYCIRFVPAEMGTHTVSV 2214

Query: 1443 KYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLERAEAGVPAEFSIWTREAGAGGLAIA 1622
            KYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLERAEAGVPAEFSIWTREAGAGGLAIA
Sbjct: 2215 KYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLERAEAGVPAEFSIWTREAGAGGLAIA 2274

Query: 1623 VEGPSKAEISFEDRKDGSCGVAYVVQEPGDYEVSVKFNEEHIPDSPFVVPVASPSGDARR 1802
            VEGPSKAEISFEDRKDGSCGVAYVVQEPGDYEVSVKFNEEHIPDSPFVVPVASPSGDARR
Sbjct: 2275 VEGPSKAEISFEDRKDGSCGVAYVVQEPGDYEVSVKFNEEHIPDSPFVVPVASPSGDARR 2334

Query: 1803 LTVSSLQESGLKVNQPASFAVSLNGAKGAIDAKVHSPSGALEECYVTEIDQDKYAVRFIP 1982
            LTVSSLQESGLKVNQPASFAVSLNGAKGAIDAKVHSPSGALEECYVTEIDQDKYAVRFIP
Sbjct: 2335 LTVSSLQESGLKVNQPASFAVSLNGAKGAIDAKVHSPSGALEECYVTEIDQDKYAVRFIP 2394

Query: 1983 RENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPGLVSAYGAGLEGGVTGSPAEFIVNT 2162
            RENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPGLVSAYGAGLEGGVTG+PAEF+VNT
Sbjct: 2395 RENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPGLVSAYGAGLEGGVTGNPAEFVVNT 2454

Query: 2163 SNAGAGALSVTIDGPSKVKMDCQECPEGYRVTYTPMAPGSYLISIKYGGPYHIGGSPFKA 2342
            SNAGAGALSVTIDGPSKVKMDCQECPEGYRVTYTPMAPGSYLISIKYGGPYHIGGSPFKA
Sbjct: 2455 SNAGAGALSVTIDGPSKVKMDCQECPEGYRVTYTPMAPGSYLISIKYGGPYHIGGSPFKA 2514

Query: 2343 RVTGHRLVSNHSLHETSSVFVDSLTKTXXXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQ 2522
            +VTG RLVSNHSLHETSSVFVDSLTK                 SKV+AKGLGLSKAYVGQ
Sbjct: 2515 KVTGPRLVSNHSLHETSSVFVDSLTKATCAPQHGAPGPGPADASKVVAKGLGLSKAYVGQ 2574

Query: 2523 KGSFTVDCSKAGNNMLLVGVHGPRTPCEEILVKHVGSRLYSVSYLLKDKGEYTLVVKWGD 2702
            K SFTVDCSKAGNNMLLVGVHGPRTPCEEILVKHVGSRLYSVSYLLKDKGEYTLVVKWGD
Sbjct: 2575 KSSFTVDCSKAGNNMLLVGVHGPRTPCEEILVKHVGSRLYSVSYLLKDKGEYTLVVKWGD 2634

Query: 2703 EHIPGSPYRVLVP 2741
            EHIPGSPYRV+VP
Sbjct: 2635 EHIPGSPYRVVVP 2647



 Score =  426 bits (1095), Expect = e-119
 Identities = 281/883 (31%), Positives = 436/883 (49%), Gaps = 52/883 (5%)
 Frame = +3

Query: 246  AQPAITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFYV-DYVNCGHVTAYGPG 422
            A+ +  DNKDG+ +V Y P EAG + +++ Y    +PGSP +  V D  +   V   GPG
Sbjct: 1398 AKMSCMDNKDGSCSVEYIPYEAGTYSLNVTYGGHQVPGSPFKVPVHDVTDASKVKCSGPG 1457

Query: 423  LSHGVV--NKPAVFTVNTKDAGEGGLSLAIEGPSKA--EISCTDNQDGTCSVSYLPVLPG 590
            LS G+V  N P  F V+T  AG   L + ++GP      +   DN DGT +V+Y+P   G
Sbjct: 1458 LSPGMVRANLPQSFQVDTSKAGVAPLQVKVQGPKGLVEPVDVVDNADGTQTVNYVPSREG 1517

Query: 591  DYSILVKYNEQHIPGSPFTARV--TGDDS--------MRMSHLKVGSAADIPINISETDL 740
             YSI V Y ++ +P SPF  +V  T D S        +  + +      +  I+  +   
Sbjct: 1518 PYSISVLYGDEEVPRSPFKVKVLPTHDASKVKASGPGLNTTGVPASLPVEFTIDAKDAGE 1577

Query: 741  SLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNGQHVASSPIPVVIS 920
             LL   +  P G+ +   ++   +G   +++VP  TG + + +K  G  +  SP  V   
Sbjct: 1578 GLLAVQITDPEGKPKKTHIQDNHDGTYTVAYVPDVTGRYTILIKYGGDEIPFSPYRVRAV 1637

Query: 921  QSEIGDASR----VRVSGRGLHEG-----HTFEPAEFIIDTRDAGYGGLSLSIEGP--SK 1067
             +  GDAS+    V + G GL  G        E     +DT+ AG G ++ ++  P  S+
Sbjct: 1638 PT--GDASKCTVTVSIGGHGLGAGIGPTIQIGEETVITVDTKAAGKGKVTCTVCTPDGSE 1695

Query: 1068 VDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTG--EGRVKESITRR 1241
            VD++  + EDGT  + Y   +PG Y+I ++F  +HVP SPF V      +  V+  +  +
Sbjct: 1696 VDVDVVENEDGTFDIFYTAPQPGKYVICVRFGGEHVPNSPFQVTALAGDQPSVQPPLRSQ 1755

Query: 1242 QRAPSVA---------------------NVGSHCDLSLKIP-EISIQDMTAQVTSPSGKS 1355
            Q AP                        +V S     L IP  I   ++T +V  PSGK 
Sbjct: 1756 QLAPQYTYAQGGQQTWAPERPLVGVNGLDVTSLRPFDLVIPFTIKKGEITGEVRMPSGKV 1815

Query: 1356 HEAEIVEGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGG 1535
             +  I + ++ T  +R+ P+E G+H + ++Y   H+PGSP QF V  +  G    V A G
Sbjct: 1816 AQPTITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFYVDYVNCG---HVTAYG 1872

Query: 1536 PGLERAEAGVPAEFSIWTREAGAGGLAIAVEGPSKAEISFEDRKDGSCGVAYVVQEPGDY 1715
            PGL       PA F++ T++AG GGL++A+EGPSKAEIS  D +DG+C V+Y+   PGDY
Sbjct: 1873 PGLTHGVVNKPATFTVNTKDAGEGGLSLAIEGPSKAEISCTDNQDGTCSVSYLPVLPGDY 1932

Query: 1716 EVSVKFNEEHIPDSPFVVPVASPSGDARRLTVSSLQESGLKVNQPASFAVSLNGAK-GAI 1892
             + VK+NE+H+P SPF   V   +GD       S++ S LKV   A   ++++      +
Sbjct: 1933 SILVKYNEQHVPGSPFTARV---TGD------DSMRMSHLKVGSAADIPINISETDLSLL 1983

Query: 1893 DAKVHSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPG 2072
             A V  PSG  E C +  +      + F+P+E G +L+ VK NG H+  SP  + + +  
Sbjct: 1984 TATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNGQHVASSPIPVVISQ-S 2042

Query: 2073 HGGDPGLVSAYGAGLEGGVTGSPAEFIVNTSNAGAGALSVTIDGPSKVKMDCQECPEG-Y 2249
              GD   V   G GL  G T  PAEFI++T +AG G LS++I+GPSKV ++ ++  +G  
Sbjct: 2043 EIGDASRVRVSGQGLHEGHTFEPAEFIIDTRDAGYGGLSLSIEGPSKVDINTEDLEDGTC 2102

Query: 2250 RVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSVFVDSLTKTXX 2429
            RVTY P  PG+Y+I+IK+    H+ GSPF  +VTG   V             +S+T+   
Sbjct: 2103 RVTYCPTEPGNYIINIKF-ADQHVPGSPFSVKVTGEGRVK------------ESITR--- 2146

Query: 2430 XXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKAGNNMLLVGVHGPRTPCEE 2609
                               +    S A VG     ++   +     +   V  P     E
Sbjct: 2147 -------------------RRRAPSVANVGSHCDLSLKIPEISIQDMTAQVTSPSGKTHE 2187

Query: 2610 ILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLV 2738
              +    +  Y + ++  + G +T+ VK+  +H+PGSP++  V
Sbjct: 2188 AEIVEGENHTYCIRFVPAEMGTHTVSVKYKGQHVPGSPFQFTV 2230



 Score =  343 bits (879), Expect = 7e-94
 Identities = 266/889 (29%), Positives = 409/889 (46%), Gaps = 44/889 (4%)
 Frame = +3

Query: 204  GEITGEVRMPSGK--VAQPAITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFY 377
            GE+   ++ P G+    +P +    D T    Y P+  G+H + + +  + IP SP    
Sbjct: 414  GEVEVVIQDPMGQKGTVEPQLEARGDSTYRCSYQPTMEGVHTVHVTFAGVPIPRSPYTVT 473

Query: 378  VDYV-NCGHVTAYGPGLS-HGV-VNKPAVFTVNTKDAGEGGLSLAIEGPSKAE-ISCTDN 545
            V    N     A G GL   GV V + A F V TK AG G L + ++GP   E +   D 
Sbjct: 474  VGQACNPSACRAVGRGLQPKGVRVKETADFKVYTKGAGSGELKVTVKGPKGEERVKQKDL 533

Query: 546  QDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARV---TGDDSMR-----MSHLKVGS 701
             DG     Y P++PG Y + + +  Q+I  SPF  +V    G+  +R     +    VG 
Sbjct: 534  GDGVYGFEYYPMVPGTYIVTITWGGQNIGRSPFEVKVGTECGNQKVRAWGPGLEGGVVGK 593

Query: 702  AADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNG 881
            +AD  +     D+  L  +V  PS  +  C  K   +G   + + P+E GE+ VHV  N 
Sbjct: 594  SADFVVEAIGDDVGTLGFSVEGPSQAKIECDDKG--DGSCDVRYWPQEAGEYAVHVLCNS 651

Query: 882  QHVASSPIPVVISQSEIGDA------SRVRVSGRGLHEGHTF--EPAEFIIDTRDAGYGG 1037
            + +  SP       ++I DA       RV+  G GL +      +PAEF +D +  G   
Sbjct: 652  EDIRLSPF-----MADIRDAPQDFHPDRVKARGPGLEKTGVAVNKPAEFTVDAKHGGKAP 706

Query: 1038 LSLSIEGPS--KVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTGE 1211
            L + ++      V+   +D  +GT   +Y P +P  +   + +    +P SPF V V G 
Sbjct: 707  LRVQVQDNEGCPVEALVKDNGNGTYSCSYVPRKPVKHTAMVSWGGVSIPNSPFRVNV-GA 765

Query: 1212 GRVKESITRRQRAPSVANVG--SHCDLSLKIP-------EISIQDMTAQ-VTSPSGKSHE 1361
            G     +  +   P VA  G  +H      +        ++SI    A  V  P+    +
Sbjct: 766  GSHPNKV--KVYGPGVAKTGLKAHEPTYFTVDCAEAGQGDVSIGIKCAPGVVGPAEADID 823

Query: 1362 AEIVEGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPG 1541
             +I+  +N T+ +++ P   G +T+ V +  Q  P SP +  V P  +  A KV+A GPG
Sbjct: 824  FDIIRNDNDTFTVKYTPRGAGSYTIMVLFADQATPTSPIRVKVEPSHD--ASKVKAEGPG 881

Query: 1542 LERA--EAGVPAEFSIWTREAGAGGLAIAVEGPSKAE----ISFEDRKDGSCGVAYVVQE 1703
            L R   E G P  F++  + AG G L +   G +K +    +   D  D +  V Y   +
Sbjct: 882  LSRTGVELGKPTHFTVNAKAAGKGKLDVQFSGLTKGDAVRDVDIIDHHDNTYTVKYTPVQ 941

Query: 1704 PGDYEVSVKFNEEHIPDSPFVVPVASPSGDARRLTVSSLQESGLKVNQPASFAVSLNGA- 1880
             G   V+V +  + IP SPF V V SPS D  ++ VS L E  + V +   F V   GA 
Sbjct: 942  QGPVGVNVTYGGDPIPKSPFSVAV-SPSLDLSKIKVSGLGEK-VDVGKDQEFTVKSKGAG 999

Query: 1881 -KGAIDAKVHSPSGALEECYVTE-IDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKI 2054
             +G + +K+  PSGA   C V   +  D   VRF+PRE G Y ++V ++G  +PGSPF +
Sbjct: 1000 GQGKVASKIVGPSGAAVPCKVEPGLGADNSVVRFLPREEGPYEVEVTYDGVPVPGSPFPL 1059

Query: 2055 RVGEPGHGGDPGLVSAYGAGLEGGVTGSPAEFIVNTSNAGAGALSVTIDGPSKVKMDCQE 2234
                P     P  V A+G GL+GG  GSPA F ++T  AG G L +T++GP + +++C +
Sbjct: 1060 EAVAPTK---PSKVKAFGPGLQGGSAGSPARFTIDTKGAGTGGLGLTVEGPCEAQLECLD 1116

Query: 2235 CPEGY-RVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSVFVDS 2411
              +G   V+Y P  PG Y I+I +    HI GSPFKA V                     
Sbjct: 1117 NGDGTCSVSYVPTEPGDYNINILFADT-HIPGSPFKAHVV-------------------- 1155

Query: 2412 LTKTXXXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKAGNNMLLVGVHGP 2591
                                SKV   G GL +A  G+ G F VDCS AG+  L + +   
Sbjct: 1156 ---------------PCFDASKVKCSGPGLERATAGEVGQFQVDCSSAGSAELTIEICSE 1200

Query: 2592 RTPCEEILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLV 2738
                 E+ ++  G   ++++Y+    G YT+ +K+G + +P  P ++ V
Sbjct: 1201 AGLPAEVYIQDHGDGTHTITYIPLCPGAYTVTIKYGGQPVPNFPSKLQV 1249



 Score =  316 bits (809), Expect = 9e-86
 Identities = 229/760 (30%), Positives = 358/760 (47%), Gaps = 43/760 (5%)
 Frame = +3

Query: 189  FTIK------KGEITGEVRMPSG-----KVAQPAITDNKDGTVTVRYAPSEAGLHEMDIR 335
            FT+K      +G++  ++  PSG     KV      DN      VR+ P E G +E+++ 
Sbjct: 991  FTVKSKGAGGQGKVASKIVGPSGAAVPCKVEPGLGADNS----VVRFLPREEGPYEVEVT 1046

Query: 336  YDNMHIPGSPLQFY-VDYVNCGHVTAYGPGLSHGVVNKPAVFTVNTKDAGEGGLSLAIEG 512
            YD + +PGSP     V       V A+GPGL  G    PA FT++TK AG GGL L +EG
Sbjct: 1047 YDGVPVPGSPFPLEAVAPTKPSKVKAFGPGLQGGSAGSPARFTIDTKGAGTGGLGLTVEG 1106

Query: 513  PSKAEISCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARVTG--DDSM---- 674
            P +A++ C DN DGTCSVSY+P  PGDY+I + + + HIPGSPF A V    D S     
Sbjct: 1107 PCEAQLECLDNGDGTCSVSYVPTEPGDYNINILFADTHIPGSPFKAHVVPCFDASKVKCS 1166

Query: 675  --RMSHLKVGSAADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKET 848
               +     G      ++ S    + LT  +   +G      ++   +G   I+++P   
Sbjct: 1167 GPGLERATAGEVGQFQVDCSSAGSAELTIEICSEAGLPAEVYIQDHGDGTHTITYIPLCP 1226

Query: 849  GEHLVHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEGHTFEPA--EFIIDTR- 1019
            G + V +K  GQ V + P  + +  +   D S V+  G G+     F  A  EF +D R 
Sbjct: 1227 GAYTVTIKYGGQPVPNFPSKLQVEPAV--DTSGVQCYGPGIEGQGVFREATTEFSVDARA 1284

Query: 1020 --DAGYGGLSLSIEGPS--KVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSP 1187
                G   +   +  PS    +   +D  DG  +V Y P E G + +++ +    VP SP
Sbjct: 1285 LTQTGGPHVKARVANPSGNLTETYVQDRGDGMYKVEYTPYEEGLHSVDVTYDGSPVPSSP 1344

Query: 1188 FSVKVTGEGRVKESITRRQRAPSVANVGSHCDLSLKIPEISIQDMTAQVTSPSGKSHEAE 1367
            F V VT EG     +                  +++        +   V  PS    +  
Sbjct: 1345 FQVPVT-EGCDPSRVRVHGPGIQSGTTNKPNKFTVETRGAGTGGLGLAVEGPS--EAKMS 1401

Query: 1368 IVEGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLE 1547
             ++ ++ +  + ++P E G ++++V Y G  VPGSPF+  V  + +  A KV+  GPGL 
Sbjct: 1402 CMDNKDGSCSVEYIPYEAGTYSLNVTYGGHQVPGSPFKVPVHDVTD--ASKVKCSGPGLS 1459

Query: 1548 --RAEAGVPAEFSIWTREAGAGGLAIAVEGPS--KAEISFEDRKDGSCGVAYVVQEPGDY 1715
                 A +P  F + T +AG   L + V+GP      +   D  DG+  V YV    G Y
Sbjct: 1460 PGMVRANLPQSFQVDTSKAGVAPLQVKVQGPKGLVEPVDVVDNADGTQTVNYVPSREGPY 1519

Query: 1716 EVSVKFNEEHIPDSPFVVPVASPSGDARRLTVS--SLQESGLKVNQPASFAVSLNGA-KG 1886
             +SV + +E +P SPF V V  P+ DA ++  S   L  +G+  + P  F +    A +G
Sbjct: 1520 SISVLYGDEEVPRSPFKVKVL-PTHDASKVKASGPGLNTTGVPASLPVEFTIDAKDAGEG 1578

Query: 1887 AIDAKVHSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGE 2066
             +  ++  P G  ++ ++ +     Y V ++P   G Y I +K+ G  IP SP+++R   
Sbjct: 1579 LLAVQITDPEGKPKKTHIQDNHDGTYTVAYVPDVTGRYTILIKYGGDEIPFSPYRVRAVP 1638

Query: 2067 PGHGGDPGL-VSAYGAGLEGGV-----TGSPAEFIVNTSNAGAGALSVTIDGP--SKVKM 2222
             G      + VS  G GL  G+      G      V+T  AG G ++ T+  P  S+V +
Sbjct: 1639 TGDASKCTVTVSIGGHGLGAGIGPTIQIGEETVITVDTKAAGKGKVTCTVCTPDGSEVDV 1698

Query: 2223 DCQECPEG-YRVTYTPMAPGSYLISIKYGGPYHIGGSPFK 2339
            D  E  +G + + YT   PG Y+I +++GG  H+  SPF+
Sbjct: 1699 DVVENEDGTFDIFYTAPQPGKYVICVRFGGE-HVPNSPFQ 1737



 Score =  289 bits (739), Expect = 1e-77
 Identities = 247/893 (27%), Positives = 387/893 (43%), Gaps = 47/893 (5%)
 Frame = +3

Query: 201  KGEITGEVRMPSGKVAQPAITDNKDG--TVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQF 374
            +GE+   V  P+G   +  +T N D   T +V Y P   G H++ + +   HI  SP + 
Sbjct: 313  QGEVLVYVEDPAGHQEEAKVTANNDKNRTFSVWYVPEVTGTHKVTVLFAGQHIAKSPFEV 372

Query: 375  YVD--YVNCGHVTAYGPGL--SHGVVNKPAVFTVNTKDAGEGGLSLAIEGP----SKAEI 530
            YVD    +   VTA GPGL  S  + NK   F + T  AG G + + I+ P       E 
Sbjct: 373  YVDKSQGDASKVTAQGPGLEPSGNIANKTTYFEIFTAGAGTGEVEVVIQDPMGQKGTVEP 432

Query: 531  SCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARV----------TGDDSMRM 680
                  D T   SY P + G +++ V +    IP SP+T  V               ++ 
Sbjct: 433  QLEARGDSTYRCSYQPTMEGVHTVHVTFAGVPIPRSPYTVTVGQACNPSACRAVGRGLQP 492

Query: 681  SHLKVGSAADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHL 860
              ++V   AD  +         L  TV  P G EE    K L +G  G  + P   G ++
Sbjct: 493  KGVRVKETADFKVYTKGAGSGELKVTVKGPKG-EERVKQKDLGDGVYGFEYYPMVPGTYI 551

Query: 861  VHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEGHTFEPAEFIIDTRDAGYGGL 1040
            V +   GQ++  SP  V +  +E G+  +VR  G GL  G   + A+F+++      G L
Sbjct: 552  VTITWGGQNIGRSPFEVKVG-TECGN-QKVRAWGPGLEGGVVGKSADFVVEAIGDDVGTL 609

Query: 1041 SLSIEGPSKVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTGEGRV 1220
              S+EGPS+  I  +D  DG+C V Y P E G Y +++    + +  SPF   +    + 
Sbjct: 610  GFSVEGPSQAKIECDDKGDGSCDVRYWPQEAGEYAVHVLCNSEDIRLSPFMADIRDAPQD 669

Query: 1221 KESITRRQRAPSVANVG----SHCDLSLKIPEISIQDMTAQVTSPSGKSHEAEIVEGENH 1388
                  + R P +   G       + ++         +  QV    G   EA + +  N 
Sbjct: 670  FHPDRVKARGPGLEKTGVAVNKPAEFTVDAKHGGKAPLRVQVQDNEGCPVEALVKDNGNG 729

Query: 1389 TYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAH--KVRAGGPGLERA--E 1556
            TY   +VP +   HT  V + G  +P SPF+  VG     G+H  KV+  GPG+ +   +
Sbjct: 730  TYSCSYVPRKPVKHTAMVSWGGVSIPNSPFRVNVG----AGSHPNKVKVYGPGVAKTGLK 785

Query: 1557 AGVPAEFSIWTREAGAGGLAIAVE------GPSKAEISFE--DRKDGSCGVAYVVQEPGD 1712
            A  P  F++   EAG G ++I ++      GP++A+I F+     + +  V Y  +  G 
Sbjct: 786  AHEPTYFTVDCAEAGQGDVSIGIKCAPGVVGPAEADIDFDIIRNDNDTFTVKYTPRGAGS 845

Query: 1713 YEVSVKFNEEHIPDSPFVVPVASPSGDARRLTVS--SLQESGLKVNQPASFAVSLNGA-K 1883
            Y + V F ++  P SP  V V  PS DA ++      L  +G+++ +P  F V+   A K
Sbjct: 846  YTIMVLFADQATPTSPIRVKV-EPSHDASKVKAEGPGLSRTGVELGKPTHFTVNAKAAGK 904

Query: 1884 GAIDAKVH--SPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIR 2057
            G +D +    +   A+ +  + +   + Y V++ P + G   ++V + G  IP SPF + 
Sbjct: 905  GKLDVQFSGLTKGDAVRDVDIIDHHDNTYTVKYTPVQQGPVGVNVTYGGDPIPKSPFSVA 964

Query: 2058 VGEPGHGGDPGLVSAYGAGLEGGVTGSPAEFIVNTSNAGA-GALSVTIDGPSKVKMDCQE 2234
            V       D   +   G G +  V G   EF V +  AG  G ++  I GPS   + C+ 
Sbjct: 965  VSP---SLDLSKIKVSGLGEKVDV-GKDQEFTVKSKGAGGQGKVASKIVGPSGAAVPCKV 1020

Query: 2235 CP----EGYRVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSVF 2402
             P    +   V + P   G Y + + Y G   + GSPF                      
Sbjct: 1021 EPGLGADNSVVRFLPREEGPYEVEVTYDG-VPVPGSPFP--------------------- 1058

Query: 2403 VDSLTKTXXXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKAGNNMLLVGV 2582
            ++++  T                SKV A G GL     G    FT+D   AG   L + V
Sbjct: 1059 LEAVAPT--------------KPSKVKAFGPGLQGGSAGSPARFTIDTKGAGTGGLGLTV 1104

Query: 2583 HGPRTPCE-EILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLV 2738
             G   PCE ++     G    SVSY+  + G+Y + + + D HIPGSP++  V
Sbjct: 1105 EG---PCEAQLECLDNGDGTCSVSYVPTEPGDYNINILFADTHIPGSPFKAHV 1154



 Score =  232 bits (592), Expect = 1e-60
 Identities = 234/841 (27%), Positives = 366/841 (43%), Gaps = 50/841 (5%)
 Frame = +3

Query: 354  PGSPLQFYVDYVNCGHVTAYGPGL--SHGVVNKPAVFTVNTKDAGEGGLSLAIEGPS--- 518
            PG+PL+     +N     AYGPG+  +  +V K A FTV T+ AG+G + + +E P+   
Sbjct: 271  PGAPLR---PKLNPKKARAYGPGIEPTGNMVKKRAEFTVETRSAGQGEVLVYVEDPAGHQ 327

Query: 519  -KAEISCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARV--TGDDSMRMSHL 689
             +A+++  ++++ T SV Y+P + G + + V +  QHI  SPF   V  +  D+ +++  
Sbjct: 328  EEAKVTANNDKNRTFSVWYVPEVTGTHKVTVLFAGQHIAKSPFEVYVDKSQGDASKVTAQ 387

Query: 690  KVGSAADIPINISETDLSLLTA---------TVVPPSGRE---EPCLLKRLRNGHVGISF 833
              G      I    T   + TA          +  P G++   EP L  R  +     S+
Sbjct: 388  GPGLEPSGNIANKTTYFEIFTAGAGTGEVEVVIQDPMGQKGTVEPQLEAR-GDSTYRCSY 446

Query: 834  VPKETGEHLVHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEG--HTFEPAEFI 1007
             P   G H VHV   G  +  SP  V + Q+   + S  R  GRGL        E A+F 
Sbjct: 447  QPTMEGVHTVHVTFAGVPIPRSPYTVTVGQA--CNPSACRAVGRGLQPKGVRVKETADFK 504

Query: 1008 IDTRDAGYGGLSLSIEGPSKVD-INTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGS 1184
            + T+ AG G L ++++GP   + +  +DL DG     Y P  PG YI+ I +  Q++  S
Sbjct: 505  VYTKGAGSGELKVTVKGPKGEERVKQKDLGDGVYGFEYYPMVPGTYIVTITWGGQNIGRS 564

Query: 1185 PFSVKVTGE-GRVKESITRRQRAPSVAN--VGSHCDLSLKIPEISIQDMTAQVTSPSGKS 1355
            PF VKV  E G  K     R   P +    VG   D  ++     +  +   V  PS   
Sbjct: 565  PFEVKVGTECGNQKV----RAWGPGLEGGVVGKSADFVVEAIGDDVGTLGFSVEGPSQAK 620

Query: 1356 HEAEIVEGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEG-GAHKVRAG 1532
             E +  +  + +  +R+ P E G + V V    + +  SPF   +    +     +V+A 
Sbjct: 621  IECD--DKGDGSCDVRYWPQEAGEYAVHVLCNSEDIRLSPFMADIRDAPQDFHPDRVKAR 678

Query: 1533 GPGLERAEAGV--PAEFSIWTREAGAGGLAIAVEGPS--KAEISFEDRKDGSCGVAYVVQ 1700
            GPGLE+    V  PAEF++  +  G   L + V+       E   +D  +G+   +YV +
Sbjct: 679  GPGLEKTGVAVNKPAEFTVDAKHGGKAPLRVQVQDNEGCPVEALVKDNGNGTYSCSYVPR 738

Query: 1701 EPGDYEVSVKFNEEHIPDSPFVVPVASPSGDAR-RLTVSSLQESGLKVNQPASFAVS-LN 1874
            +P  +   V +    IP+SPF V V + S   + ++    + ++GLK ++P  F V    
Sbjct: 739  KPVKHTAMVSWGGVSIPNSPFRVNVGAGSHPNKVKVYGPGVAKTGLKAHEPTYFTVDCAE 798

Query: 1875 GAKGAIDAKVH------SPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIP 2036
              +G +   +        P+ A  +  +   D D + V++ PR  G Y I V F     P
Sbjct: 799  AGQGDVSIGIKCAPGVVGPAEADIDFDIIRNDNDTFTVKYTPRGAGSYTIMVLFADQATP 858

Query: 2037 GSPFKIRVGEPGHGGDPGLVSAYGAGLE--GGVTGSPAEFIVNTSNAGAGALSVTIDGPS 2210
             SP +++V EP H  D   V A G GL   G   G P  F VN   AG G L V   G +
Sbjct: 859  TSPIRVKV-EPSH--DASKVKAEGPGLSRTGVELGKPTHFTVNAKAAGKGKLDVQFSGLT 915

Query: 2211 K----VKMDCQECPEG-YRVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNH 2375
            K      +D  +  +  Y V YTP+  G   +++ YGG   I  SPF   V+        
Sbjct: 916  KGDAVRDVDIIDHHDNTYTVKYTPVQQGPVGVNVTYGGD-PIPKSPFSVAVS-------- 966

Query: 2376 SLHETSSVFVDSLTKTXXXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKA 2555
                                            SK+   GLG  K  VG+   FTV    A
Sbjct: 967  ---------------------------PSLDLSKIKVSGLG-EKVDVGKDQEFTVKSKGA 998

Query: 2556 GNN----MLLVGVHGPRTPCEEILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSP 2723
            G        +VG  G   PC+  +   +G+    V +L +++G Y + V +    +PGSP
Sbjct: 999  GGQGKVASKIVGPSGAAVPCK--VEPGLGADNSVVRFLPREEGPYEVEVTYDGVPVPGSP 1056

Query: 2724 Y 2726
            +
Sbjct: 1057 F 1057


>ref|NP_001447.2| filamin-A isoform 1 [Homo sapiens].
          Length = 2639

 Score = 1758 bits (4554), Expect = 0.0
 Identities = 868/913 (95%), Positives = 879/913 (96%)
 Frame = +3

Query: 3    PFQVTALAGEQPSVXXXXXXXXXXXXYTYAQGGQQTWAPERPLVGVNGLDVTSLRPFDLV 182
            PFQVTALAG+QPSV            YTYAQGGQQTWAPERPLVGVNGLDVTSLRPFDLV
Sbjct: 1727 PFQVTALAGDQPSVQPPLRSQQLAPQYTYAQGGQQTWAPERPLVGVNGLDVTSLRPFDLV 1786

Query: 183  IPFTIKKGEITGEVRMPSGKVAQPAITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGS 362
            IPFTIKKGEITGEVRMPSGKVAQP ITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGS
Sbjct: 1787 IPFTIKKGEITGEVRMPSGKVAQPTITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGS 1846

Query: 363  PLQFYVDYVNCGHVTAYGPGLSHGVVNKPAVFTVNTKDAGEGGLSLAIEGPSKAEISCTD 542
            PLQFYVDYVNCGHVTAYGPGL+HGVVNKPA FTVNTKDAGEGGLSLAIEGPSKAEISCTD
Sbjct: 1847 PLQFYVDYVNCGHVTAYGPGLTHGVVNKPATFTVNTKDAGEGGLSLAIEGPSKAEISCTD 1906

Query: 543  NQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARVTGDDSMRMSHLKVGSAADIPIN 722
            NQDGTCSVSYLPVLPGDYSILVKYNEQH+PGSPFTARVTGDDSMRMSHLKVGSAADIPIN
Sbjct: 1907 NQDGTCSVSYLPVLPGDYSILVKYNEQHVPGSPFTARVTGDDSMRMSHLKVGSAADIPIN 1966

Query: 723  ISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNGQHVASSP 902
            ISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNGQHVASSP
Sbjct: 1967 ISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNGQHVASSP 2026

Query: 903  IPVVISQSEIGDASRVRVSGRGLHEGHTFEPAEFIIDTRDAGYGGLSLSIEGPSKVDINT 1082
            IPVVISQSEIGDASRVRVSG+GLHEGHTFEPAEFIIDTRDAGYGGLSLSIEGPSKVDINT
Sbjct: 2027 IPVVISQSEIGDASRVRVSGQGLHEGHTFEPAEFIIDTRDAGYGGLSLSIEGPSKVDINT 2086

Query: 1083 EDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTGEGRVKESITRRQRAPSVA 1262
            EDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTGEGRVKESITRR+RAPSVA
Sbjct: 2087 EDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTGEGRVKESITRRRRAPSVA 2146

Query: 1263 NVGSHCDLSLKIPEISIQDMTAQVTSPSGKSHEAEIVEGENHTYCIRFVPAEMGMHTVSV 1442
            NVGSHCDLSLKIPEISIQDMTAQVTSPSGK+HEAEIVEGENHTYCIRFVPAEMG HTVSV
Sbjct: 2147 NVGSHCDLSLKIPEISIQDMTAQVTSPSGKTHEAEIVEGENHTYCIRFVPAEMGTHTVSV 2206

Query: 1443 KYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLERAEAGVPAEFSIWTREAGAGGLAIA 1622
            KYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLERAEAGVPAEFSIWTREAGAGGLAIA
Sbjct: 2207 KYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLERAEAGVPAEFSIWTREAGAGGLAIA 2266

Query: 1623 VEGPSKAEISFEDRKDGSCGVAYVVQEPGDYEVSVKFNEEHIPDSPFVVPVASPSGDARR 1802
            VEGPSKAEISFEDRKDGSCGVAYVVQEPGDYEVSVKFNEEHIPDSPFVVPVASPSGDARR
Sbjct: 2267 VEGPSKAEISFEDRKDGSCGVAYVVQEPGDYEVSVKFNEEHIPDSPFVVPVASPSGDARR 2326

Query: 1803 LTVSSLQESGLKVNQPASFAVSLNGAKGAIDAKVHSPSGALEECYVTEIDQDKYAVRFIP 1982
            LTVSSLQESGLKVNQPASFAVSLNGAKGAIDAKVHSPSGALEECYVTEIDQDKYAVRFIP
Sbjct: 2327 LTVSSLQESGLKVNQPASFAVSLNGAKGAIDAKVHSPSGALEECYVTEIDQDKYAVRFIP 2386

Query: 1983 RENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPGLVSAYGAGLEGGVTGSPAEFIVNT 2162
            RENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPGLVSAYGAGLEGGVTG+PAEF+VNT
Sbjct: 2387 RENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPGLVSAYGAGLEGGVTGNPAEFVVNT 2446

Query: 2163 SNAGAGALSVTIDGPSKVKMDCQECPEGYRVTYTPMAPGSYLISIKYGGPYHIGGSPFKA 2342
            SNAGAGALSVTIDGPSKVKMDCQECPEGYRVTYTPMAPGSYLISIKYGGPYHIGGSPFKA
Sbjct: 2447 SNAGAGALSVTIDGPSKVKMDCQECPEGYRVTYTPMAPGSYLISIKYGGPYHIGGSPFKA 2506

Query: 2343 RVTGHRLVSNHSLHETSSVFVDSLTKTXXXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQ 2522
            +VTG RLVSNHSLHETSSVFVDSLTK                 SKV+AKGLGLSKAYVGQ
Sbjct: 2507 KVTGPRLVSNHSLHETSSVFVDSLTKATCAPQHGAPGPGPADASKVVAKGLGLSKAYVGQ 2566

Query: 2523 KGSFTVDCSKAGNNMLLVGVHGPRTPCEEILVKHVGSRLYSVSYLLKDKGEYTLVVKWGD 2702
            K SFTVDCSKAGNNMLLVGVHGPRTPCEEILVKHVGSRLYSVSYLLKDKGEYTLVVKWGD
Sbjct: 2567 KSSFTVDCSKAGNNMLLVGVHGPRTPCEEILVKHVGSRLYSVSYLLKDKGEYTLVVKWGD 2626

Query: 2703 EHIPGSPYRVLVP 2741
            EHIPGSPYRV+VP
Sbjct: 2627 EHIPGSPYRVVVP 2639



 Score =  430 bits (1105), Expect = e-120
 Identities = 281/877 (32%), Positives = 438/877 (49%), Gaps = 46/877 (5%)
 Frame = +3

Query: 246  AQPAITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFYV-DYVNCGHVTAYGPG 422
            A+ +  DNKDG+ +V Y P EAG + +++ Y    +PGSP +  V D  +   V   GPG
Sbjct: 1398 AKMSCMDNKDGSCSVEYIPYEAGTYSLNVTYGGHQVPGSPFKVPVHDVTDASKVKCSGPG 1457

Query: 423  LSHGVV--NKPAVFTVNTKDAGEGGLSLAIEGPSKA--EISCTDNQDGTCSVSYLPVLPG 590
            LS G+V  N P  F V+T  AG   L + ++GP      +   DN DGT +V+Y+P   G
Sbjct: 1458 LSPGMVRANLPQSFQVDTSKAGVAPLQVKVQGPKGLVEPVDVVDNADGTQTVNYVPSREG 1517

Query: 591  DYSILVKYNEQHIPGSPFTARV--TGDDS--------MRMSHLKVGSAADIPINISETDL 740
             YSI V Y ++ +P SPF  +V  T D S        +  + +      +  I+  +   
Sbjct: 1518 PYSISVLYGDEEVPRSPFKVKVLPTHDASKVKASGPGLNTTGVPASLPVEFTIDAKDAGE 1577

Query: 741  SLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNGQHVASSPIPVVIS 920
             LL   +  P G+ +   ++   +G   +++VP  TG + + +K  G  +  SP  V   
Sbjct: 1578 GLLAVQITDPEGKPKKTHIQDNHDGTYTVAYVPDVTGRYTILIKYGGDEIPFSPYRVRAV 1637

Query: 921  QSEIGDASRVRVSGRGLHEGHTFEPAE---FIIDTRDAGYGGLSLSIEGP--SKVDINTE 1085
             +  GDAS+  V+G G+  G T +  E     +DT+ AG G ++ ++  P  S+VD++  
Sbjct: 1638 PT--GDASKCTVTGAGI--GPTIQIGEETVITVDTKAAGKGKVTCTVCTPDGSEVDVDVV 1693

Query: 1086 DLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTG--EGRVKESITRRQRAPSV 1259
            + EDGT  + Y   +PG Y+I ++F  +HVP SPF V      +  V+  +  +Q AP  
Sbjct: 1694 ENEDGTFDIFYTAPQPGKYVICVRFGGEHVPNSPFQVTALAGDQPSVQPPLRSQQLAPQY 1753

Query: 1260 A---------------------NVGSHCDLSLKIP-EISIQDMTAQVTSPSGKSHEAEIV 1373
                                  +V S     L IP  I   ++T +V  PSGK  +  I 
Sbjct: 1754 TYAQGGQQTWAPERPLVGVNGLDVTSLRPFDLVIPFTIKKGEITGEVRMPSGKVAQPTIT 1813

Query: 1374 EGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLERA 1553
            + ++ T  +R+ P+E G+H + ++Y   H+PGSP QF V  +  G    V A GPGL   
Sbjct: 1814 DNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFYVDYVNCG---HVTAYGPGLTHG 1870

Query: 1554 EAGVPAEFSIWTREAGAGGLAIAVEGPSKAEISFEDRKDGSCGVAYVVQEPGDYEVSVKF 1733
                PA F++ T++AG GGL++A+EGPSKAEIS  D +DG+C V+Y+   PGDY + VK+
Sbjct: 1871 VVNKPATFTVNTKDAGEGGLSLAIEGPSKAEISCTDNQDGTCSVSYLPVLPGDYSILVKY 1930

Query: 1734 NEEHIPDSPFVVPVASPSGDARRLTVSSLQESGLKVNQPASFAVSLNGAK-GAIDAKVHS 1910
            NE+H+P SPF   V   +GD       S++ S LKV   A   ++++      + A V  
Sbjct: 1931 NEQHVPGSPFTARV---TGD------DSMRMSHLKVGSAADIPINISETDLSLLTATVVP 1981

Query: 1911 PSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPG 2090
            PSG  E C +  +      + F+P+E G +L+ VK NG H+  SP  + + +    GD  
Sbjct: 1982 PSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNGQHVASSPIPVVISQ-SEIGDAS 2040

Query: 2091 LVSAYGAGLEGGVTGSPAEFIVNTSNAGAGALSVTIDGPSKVKMDCQECPEG-YRVTYTP 2267
             V   G GL  G T  PAEFI++T +AG G LS++I+GPSKV ++ ++  +G  RVTY P
Sbjct: 2041 RVRVSGQGLHEGHTFEPAEFIIDTRDAGYGGLSLSIEGPSKVDINTEDLEDGTCRVTYCP 2100

Query: 2268 MAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSVFVDSLTKTXXXXXXXX 2447
              PG+Y+I+IK+    H+ GSPF  +VTG   V             +S+T+         
Sbjct: 2101 TEPGNYIINIKF-ADQHVPGSPFSVKVTGEGRVK------------ESITR--------- 2138

Query: 2448 XXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKAGNNMLLVGVHGPRTPCEEILVKHV 2627
                         +    S A VG     ++   +     +   V  P     E  +   
Sbjct: 2139 -------------RRRAPSVANVGSHCDLSLKIPEISIQDMTAQVTSPSGKTHEAEIVEG 2185

Query: 2628 GSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLV 2738
             +  Y + ++  + G +T+ VK+  +H+PGSP++  V
Sbjct: 2186 ENHTYCIRFVPAEMGTHTVSVKYKGQHVPGSPFQFTV 2222



 Score =  343 bits (879), Expect = 7e-94
 Identities = 266/889 (29%), Positives = 409/889 (46%), Gaps = 44/889 (4%)
 Frame = +3

Query: 204  GEITGEVRMPSGK--VAQPAITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFY 377
            GE+   ++ P G+    +P +    D T    Y P+  G+H + + +  + IP SP    
Sbjct: 414  GEVEVVIQDPMGQKGTVEPQLEARGDSTYRCSYQPTMEGVHTVHVTFAGVPIPRSPYTVT 473

Query: 378  VDYV-NCGHVTAYGPGLS-HGV-VNKPAVFTVNTKDAGEGGLSLAIEGPSKAE-ISCTDN 545
            V    N     A G GL   GV V + A F V TK AG G L + ++GP   E +   D 
Sbjct: 474  VGQACNPSACRAVGRGLQPKGVRVKETADFKVYTKGAGSGELKVTVKGPKGEERVKQKDL 533

Query: 546  QDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARV---TGDDSMR-----MSHLKVGS 701
             DG     Y P++PG Y + + +  Q+I  SPF  +V    G+  +R     +    VG 
Sbjct: 534  GDGVYGFEYYPMVPGTYIVTITWGGQNIGRSPFEVKVGTECGNQKVRAWGPGLEGGVVGK 593

Query: 702  AADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNG 881
            +AD  +     D+  L  +V  PS  +  C  K   +G   + + P+E GE+ VHV  N 
Sbjct: 594  SADFVVEAIGDDVGTLGFSVEGPSQAKIECDDKG--DGSCDVRYWPQEAGEYAVHVLCNS 651

Query: 882  QHVASSPIPVVISQSEIGDA------SRVRVSGRGLHEGHTF--EPAEFIIDTRDAGYGG 1037
            + +  SP       ++I DA       RV+  G GL +      +PAEF +D +  G   
Sbjct: 652  EDIRLSPF-----MADIRDAPQDFHPDRVKARGPGLEKTGVAVNKPAEFTVDAKHGGKAP 706

Query: 1038 LSLSIEGPS--KVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTGE 1211
            L + ++      V+   +D  +GT   +Y P +P  +   + +    +P SPF V V G 
Sbjct: 707  LRVQVQDNEGCPVEALVKDNGNGTYSCSYVPRKPVKHTAMVSWGGVSIPNSPFRVNV-GA 765

Query: 1212 GRVKESITRRQRAPSVANVG--SHCDLSLKIP-------EISIQDMTAQ-VTSPSGKSHE 1361
            G     +  +   P VA  G  +H      +        ++SI    A  V  P+    +
Sbjct: 766  GSHPNKV--KVYGPGVAKTGLKAHEPTYFTVDCAEAGQGDVSIGIKCAPGVVGPAEADID 823

Query: 1362 AEIVEGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPG 1541
             +I+  +N T+ +++ P   G +T+ V +  Q  P SP +  V P  +  A KV+A GPG
Sbjct: 824  FDIIRNDNDTFTVKYTPRGAGSYTIMVLFADQATPTSPIRVKVEPSHD--ASKVKAEGPG 881

Query: 1542 LERA--EAGVPAEFSIWTREAGAGGLAIAVEGPSKAE----ISFEDRKDGSCGVAYVVQE 1703
            L R   E G P  F++  + AG G L +   G +K +    +   D  D +  V Y   +
Sbjct: 882  LSRTGVELGKPTHFTVNAKAAGKGKLDVQFSGLTKGDAVRDVDIIDHHDNTYTVKYTPVQ 941

Query: 1704 PGDYEVSVKFNEEHIPDSPFVVPVASPSGDARRLTVSSLQESGLKVNQPASFAVSLNGA- 1880
             G   V+V +  + IP SPF V V SPS D  ++ VS L E  + V +   F V   GA 
Sbjct: 942  QGPVGVNVTYGGDPIPKSPFSVAV-SPSLDLSKIKVSGLGEK-VDVGKDQEFTVKSKGAG 999

Query: 1881 -KGAIDAKVHSPSGALEECYVTE-IDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKI 2054
             +G + +K+  PSGA   C V   +  D   VRF+PRE G Y ++V ++G  +PGSPF +
Sbjct: 1000 GQGKVASKIVGPSGAAVPCKVEPGLGADNSVVRFLPREEGPYEVEVTYDGVPVPGSPFPL 1059

Query: 2055 RVGEPGHGGDPGLVSAYGAGLEGGVTGSPAEFIVNTSNAGAGALSVTIDGPSKVKMDCQE 2234
                P     P  V A+G GL+GG  GSPA F ++T  AG G L +T++GP + +++C +
Sbjct: 1060 EAVAPTK---PSKVKAFGPGLQGGSAGSPARFTIDTKGAGTGGLGLTVEGPCEAQLECLD 1116

Query: 2235 CPEGY-RVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSVFVDS 2411
              +G   V+Y P  PG Y I+I +    HI GSPFKA V                     
Sbjct: 1117 NGDGTCSVSYVPTEPGDYNINILFADT-HIPGSPFKAHVV-------------------- 1155

Query: 2412 LTKTXXXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKAGNNMLLVGVHGP 2591
                                SKV   G GL +A  G+ G F VDCS AG+  L + +   
Sbjct: 1156 ---------------PCFDASKVKCSGPGLERATAGEVGQFQVDCSSAGSAELTIEICSE 1200

Query: 2592 RTPCEEILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLV 2738
                 E+ ++  G   ++++Y+    G YT+ +K+G + +P  P ++ V
Sbjct: 1201 AGLPAEVYIQDHGDGTHTITYIPLCPGAYTVTIKYGGQPVPNFPSKLQV 1249



 Score =  315 bits (808), Expect = 1e-85
 Identities = 227/755 (30%), Positives = 357/755 (47%), Gaps = 38/755 (5%)
 Frame = +3

Query: 189  FTIK------KGEITGEVRMPSG-----KVAQPAITDNKDGTVTVRYAPSEAGLHEMDIR 335
            FT+K      +G++  ++  PSG     KV      DN      VR+ P E G +E+++ 
Sbjct: 991  FTVKSKGAGGQGKVASKIVGPSGAAVPCKVEPGLGADNS----VVRFLPREEGPYEVEVT 1046

Query: 336  YDNMHIPGSPLQFY-VDYVNCGHVTAYGPGLSHGVVNKPAVFTVNTKDAGEGGLSLAIEG 512
            YD + +PGSP     V       V A+GPGL  G    PA FT++TK AG GGL L +EG
Sbjct: 1047 YDGVPVPGSPFPLEAVAPTKPSKVKAFGPGLQGGSAGSPARFTIDTKGAGTGGLGLTVEG 1106

Query: 513  PSKAEISCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARVTG--DDSM---- 674
            P +A++ C DN DGTCSVSY+P  PGDY+I + + + HIPGSPF A V    D S     
Sbjct: 1107 PCEAQLECLDNGDGTCSVSYVPTEPGDYNINILFADTHIPGSPFKAHVVPCFDASKVKCS 1166

Query: 675  --RMSHLKVGSAADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKET 848
               +     G      ++ S    + LT  +   +G      ++   +G   I+++P   
Sbjct: 1167 GPGLERATAGEVGQFQVDCSSAGSAELTIEICSEAGLPAEVYIQDHGDGTHTITYIPLCP 1226

Query: 849  GEHLVHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEGHTFEPA--EFIIDTR- 1019
            G + V +K  GQ V + P  + +  +   D S V+  G G+     F  A  EF +D R 
Sbjct: 1227 GAYTVTIKYGGQPVPNFPSKLQVEPAV--DTSGVQCYGPGIEGQGVFREATTEFSVDARA 1284

Query: 1020 --DAGYGGLSLSIEGPS--KVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSP 1187
                G   +   +  PS    +   +D  DG  +V Y P E G + +++ +    VP SP
Sbjct: 1285 LTQTGGPHVKARVANPSGNLTETYVQDRGDGMYKVEYTPYEEGLHSVDVTYDGSPVPSSP 1344

Query: 1188 FSVKVTGEGRVKESITRRQRAPSVANVGSHCDLSLKIPEISIQDMTAQVTSPSGKSHEAE 1367
            F V VT EG     +                  +++        +   V  PS    +  
Sbjct: 1345 FQVPVT-EGCDPSRVRVHGPGIQSGTTNKPNKFTVETRGAGTGGLGLAVEGPS--EAKMS 1401

Query: 1368 IVEGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLE 1547
             ++ ++ +  + ++P E G ++++V Y G  VPGSPF+  V  + +  A KV+  GPGL 
Sbjct: 1402 CMDNKDGSCSVEYIPYEAGTYSLNVTYGGHQVPGSPFKVPVHDVTD--ASKVKCSGPGLS 1459

Query: 1548 --RAEAGVPAEFSIWTREAGAGGLAIAVEGPS--KAEISFEDRKDGSCGVAYVVQEPGDY 1715
                 A +P  F + T +AG   L + V+GP      +   D  DG+  V YV    G Y
Sbjct: 1460 PGMVRANLPQSFQVDTSKAGVAPLQVKVQGPKGLVEPVDVVDNADGTQTVNYVPSREGPY 1519

Query: 1716 EVSVKFNEEHIPDSPFVVPVASPSGDARRLTVS--SLQESGLKVNQPASFAVSLNGA-KG 1886
             +SV + +E +P SPF V V  P+ DA ++  S   L  +G+  + P  F +    A +G
Sbjct: 1520 SISVLYGDEEVPRSPFKVKVL-PTHDASKVKASGPGLNTTGVPASLPVEFTIDAKDAGEG 1578

Query: 1887 AIDAKVHSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGE 2066
             +  ++  P G  ++ ++ +     Y V ++P   G Y I +K+ G  IP SP+++R   
Sbjct: 1579 LLAVQITDPEGKPKKTHIQDNHDGTYTVAYVPDVTGRYTILIKYGGDEIPFSPYRVRAVP 1638

Query: 2067 PGHGGDPGLVSAYGAGLEGGV-TGSPAEFIVNTSNAGAGALSVTIDGP--SKVKMDCQEC 2237
                GD    +  GAG+   +  G      V+T  AG G ++ T+  P  S+V +D  E 
Sbjct: 1639 T---GDASKCTVTGAGIGPTIQIGEETVITVDTKAAGKGKVTCTVCTPDGSEVDVDVVEN 1695

Query: 2238 PEG-YRVTYTPMAPGSYLISIKYGGPYHIGGSPFK 2339
             +G + + YT   PG Y+I +++GG  H+  SPF+
Sbjct: 1696 EDGTFDIFYTAPQPGKYVICVRFGGE-HVPNSPFQ 1729



 Score =  289 bits (739), Expect = 1e-77
 Identities = 247/893 (27%), Positives = 387/893 (43%), Gaps = 47/893 (5%)
 Frame = +3

Query: 201  KGEITGEVRMPSGKVAQPAITDNKDG--TVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQF 374
            +GE+   V  P+G   +  +T N D   T +V Y P   G H++ + +   HI  SP + 
Sbjct: 313  QGEVLVYVEDPAGHQEEAKVTANNDKNRTFSVWYVPEVTGTHKVTVLFAGQHIAKSPFEV 372

Query: 375  YVD--YVNCGHVTAYGPGL--SHGVVNKPAVFTVNTKDAGEGGLSLAIEGP----SKAEI 530
            YVD    +   VTA GPGL  S  + NK   F + T  AG G + + I+ P       E 
Sbjct: 373  YVDKSQGDASKVTAQGPGLEPSGNIANKTTYFEIFTAGAGTGEVEVVIQDPMGQKGTVEP 432

Query: 531  SCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARV----------TGDDSMRM 680
                  D T   SY P + G +++ V +    IP SP+T  V               ++ 
Sbjct: 433  QLEARGDSTYRCSYQPTMEGVHTVHVTFAGVPIPRSPYTVTVGQACNPSACRAVGRGLQP 492

Query: 681  SHLKVGSAADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHL 860
              ++V   AD  +         L  TV  P G EE    K L +G  G  + P   G ++
Sbjct: 493  KGVRVKETADFKVYTKGAGSGELKVTVKGPKG-EERVKQKDLGDGVYGFEYYPMVPGTYI 551

Query: 861  VHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEGHTFEPAEFIIDTRDAGYGGL 1040
            V +   GQ++  SP  V +  +E G+  +VR  G GL  G   + A+F+++      G L
Sbjct: 552  VTITWGGQNIGRSPFEVKVG-TECGN-QKVRAWGPGLEGGVVGKSADFVVEAIGDDVGTL 609

Query: 1041 SLSIEGPSKVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTGEGRV 1220
              S+EGPS+  I  +D  DG+C V Y P E G Y +++    + +  SPF   +    + 
Sbjct: 610  GFSVEGPSQAKIECDDKGDGSCDVRYWPQEAGEYAVHVLCNSEDIRLSPFMADIRDAPQD 669

Query: 1221 KESITRRQRAPSVANVG----SHCDLSLKIPEISIQDMTAQVTSPSGKSHEAEIVEGENH 1388
                  + R P +   G       + ++         +  QV    G   EA + +  N 
Sbjct: 670  FHPDRVKARGPGLEKTGVAVNKPAEFTVDAKHGGKAPLRVQVQDNEGCPVEALVKDNGNG 729

Query: 1389 TYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAH--KVRAGGPGLERA--E 1556
            TY   +VP +   HT  V + G  +P SPF+  VG     G+H  KV+  GPG+ +   +
Sbjct: 730  TYSCSYVPRKPVKHTAMVSWGGVSIPNSPFRVNVG----AGSHPNKVKVYGPGVAKTGLK 785

Query: 1557 AGVPAEFSIWTREAGAGGLAIAVE------GPSKAEISFE--DRKDGSCGVAYVVQEPGD 1712
            A  P  F++   EAG G ++I ++      GP++A+I F+     + +  V Y  +  G 
Sbjct: 786  AHEPTYFTVDCAEAGQGDVSIGIKCAPGVVGPAEADIDFDIIRNDNDTFTVKYTPRGAGS 845

Query: 1713 YEVSVKFNEEHIPDSPFVVPVASPSGDARRLTVS--SLQESGLKVNQPASFAVSLNGA-K 1883
            Y + V F ++  P SP  V V  PS DA ++      L  +G+++ +P  F V+   A K
Sbjct: 846  YTIMVLFADQATPTSPIRVKV-EPSHDASKVKAEGPGLSRTGVELGKPTHFTVNAKAAGK 904

Query: 1884 GAIDAKVH--SPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIR 2057
            G +D +    +   A+ +  + +   + Y V++ P + G   ++V + G  IP SPF + 
Sbjct: 905  GKLDVQFSGLTKGDAVRDVDIIDHHDNTYTVKYTPVQQGPVGVNVTYGGDPIPKSPFSVA 964

Query: 2058 VGEPGHGGDPGLVSAYGAGLEGGVTGSPAEFIVNTSNAGA-GALSVTIDGPSKVKMDCQE 2234
            V       D   +   G G +  V G   EF V +  AG  G ++  I GPS   + C+ 
Sbjct: 965  VSP---SLDLSKIKVSGLGEKVDV-GKDQEFTVKSKGAGGQGKVASKIVGPSGAAVPCKV 1020

Query: 2235 CP----EGYRVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSVF 2402
             P    +   V + P   G Y + + Y G   + GSPF                      
Sbjct: 1021 EPGLGADNSVVRFLPREEGPYEVEVTYDG-VPVPGSPFP--------------------- 1058

Query: 2403 VDSLTKTXXXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKAGNNMLLVGV 2582
            ++++  T                SKV A G GL     G    FT+D   AG   L + V
Sbjct: 1059 LEAVAPT--------------KPSKVKAFGPGLQGGSAGSPARFTIDTKGAGTGGLGLTV 1104

Query: 2583 HGPRTPCE-EILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLV 2738
             G   PCE ++     G    SVSY+  + G+Y + + + D HIPGSP++  V
Sbjct: 1105 EG---PCEAQLECLDNGDGTCSVSYVPTEPGDYNINILFADTHIPGSPFKAHV 1154



 Score =  232 bits (592), Expect = 1e-60
 Identities = 234/841 (27%), Positives = 366/841 (43%), Gaps = 50/841 (5%)
 Frame = +3

Query: 354  PGSPLQFYVDYVNCGHVTAYGPGL--SHGVVNKPAVFTVNTKDAGEGGLSLAIEGPS--- 518
            PG+PL+     +N     AYGPG+  +  +V K A FTV T+ AG+G + + +E P+   
Sbjct: 271  PGAPLR---PKLNPKKARAYGPGIEPTGNMVKKRAEFTVETRSAGQGEVLVYVEDPAGHQ 327

Query: 519  -KAEISCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARV--TGDDSMRMSHL 689
             +A+++  ++++ T SV Y+P + G + + V +  QHI  SPF   V  +  D+ +++  
Sbjct: 328  EEAKVTANNDKNRTFSVWYVPEVTGTHKVTVLFAGQHIAKSPFEVYVDKSQGDASKVTAQ 387

Query: 690  KVGSAADIPINISETDLSLLTA---------TVVPPSGRE---EPCLLKRLRNGHVGISF 833
              G      I    T   + TA          +  P G++   EP L  R  +     S+
Sbjct: 388  GPGLEPSGNIANKTTYFEIFTAGAGTGEVEVVIQDPMGQKGTVEPQLEAR-GDSTYRCSY 446

Query: 834  VPKETGEHLVHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEG--HTFEPAEFI 1007
             P   G H VHV   G  +  SP  V + Q+   + S  R  GRGL        E A+F 
Sbjct: 447  QPTMEGVHTVHVTFAGVPIPRSPYTVTVGQA--CNPSACRAVGRGLQPKGVRVKETADFK 504

Query: 1008 IDTRDAGYGGLSLSIEGPSKVD-INTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGS 1184
            + T+ AG G L ++++GP   + +  +DL DG     Y P  PG YI+ I +  Q++  S
Sbjct: 505  VYTKGAGSGELKVTVKGPKGEERVKQKDLGDGVYGFEYYPMVPGTYIVTITWGGQNIGRS 564

Query: 1185 PFSVKVTGE-GRVKESITRRQRAPSVAN--VGSHCDLSLKIPEISIQDMTAQVTSPSGKS 1355
            PF VKV  E G  K     R   P +    VG   D  ++     +  +   V  PS   
Sbjct: 565  PFEVKVGTECGNQKV----RAWGPGLEGGVVGKSADFVVEAIGDDVGTLGFSVEGPSQAK 620

Query: 1356 HEAEIVEGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEG-GAHKVRAG 1532
             E +  +  + +  +R+ P E G + V V    + +  SPF   +    +     +V+A 
Sbjct: 621  IECD--DKGDGSCDVRYWPQEAGEYAVHVLCNSEDIRLSPFMADIRDAPQDFHPDRVKAR 678

Query: 1533 GPGLERAEAGV--PAEFSIWTREAGAGGLAIAVEGPS--KAEISFEDRKDGSCGVAYVVQ 1700
            GPGLE+    V  PAEF++  +  G   L + V+       E   +D  +G+   +YV +
Sbjct: 679  GPGLEKTGVAVNKPAEFTVDAKHGGKAPLRVQVQDNEGCPVEALVKDNGNGTYSCSYVPR 738

Query: 1701 EPGDYEVSVKFNEEHIPDSPFVVPVASPSGDAR-RLTVSSLQESGLKVNQPASFAVS-LN 1874
            +P  +   V +    IP+SPF V V + S   + ++    + ++GLK ++P  F V    
Sbjct: 739  KPVKHTAMVSWGGVSIPNSPFRVNVGAGSHPNKVKVYGPGVAKTGLKAHEPTYFTVDCAE 798

Query: 1875 GAKGAIDAKVH------SPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIP 2036
              +G +   +        P+ A  +  +   D D + V++ PR  G Y I V F     P
Sbjct: 799  AGQGDVSIGIKCAPGVVGPAEADIDFDIIRNDNDTFTVKYTPRGAGSYTIMVLFADQATP 858

Query: 2037 GSPFKIRVGEPGHGGDPGLVSAYGAGLE--GGVTGSPAEFIVNTSNAGAGALSVTIDGPS 2210
             SP +++V EP H  D   V A G GL   G   G P  F VN   AG G L V   G +
Sbjct: 859  TSPIRVKV-EPSH--DASKVKAEGPGLSRTGVELGKPTHFTVNAKAAGKGKLDVQFSGLT 915

Query: 2211 K----VKMDCQECPEG-YRVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNH 2375
            K      +D  +  +  Y V YTP+  G   +++ YGG   I  SPF   V+        
Sbjct: 916  KGDAVRDVDIIDHHDNTYTVKYTPVQQGPVGVNVTYGGD-PIPKSPFSVAVS-------- 966

Query: 2376 SLHETSSVFVDSLTKTXXXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKA 2555
                                            SK+   GLG  K  VG+   FTV    A
Sbjct: 967  ---------------------------PSLDLSKIKVSGLG-EKVDVGKDQEFTVKSKGA 998

Query: 2556 GNN----MLLVGVHGPRTPCEEILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSP 2723
            G        +VG  G   PC+  +   +G+    V +L +++G Y + V +    +PGSP
Sbjct: 999  GGQGKVASKIVGPSGAAVPCK--VEPGLGADNSVVRFLPREEGPYEVEVTYDGVPVPGSP 1056

Query: 2724 Y 2726
            +
Sbjct: 1057 F 1057


>ref|NP_001157789.1| filamin-B isoform 1 [Homo sapiens].
          Length = 2633

 Score = 1313 bits (3399), Expect = 0.0
 Identities = 627/881 (71%), Positives = 744/881 (84%)
 Frame = +3

Query: 99   GQQTWAPERPLVGVNGLDVTSLRPFDLVIPFTIKKGEITGEVRMPSGKVAQPAITDNKDG 278
            G + W  E   V V+ ++    +PFDLVIPF ++KGEITGEV MPSGK A P I DNKDG
Sbjct: 1754 GFRPWVTEEAYVPVSDMNGLGFKPFDLVIPFAVRKGEITGEVHMPSGKTATPEIVDNKDG 1813

Query: 279  TVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFYVDYVNCGHVTAYGPGLSHGVVNKPAVF 458
            TVTVRYAP+E GLHEM I+Y   HIP SPLQFYV+Y N G V+AYGPGL +GV NK A F
Sbjct: 1814 TVTVRYAPTEVGLHEMHIKYMGSHIPESPLQFYVNYPNSGSVSAYGPGLVYGVANKTATF 1873

Query: 459  TVNTKDAGEGGLSLAIEGPSKAEISCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGS 638
            T+ T+DAGEGGL LAIEGPSKAEISC DN+DGTC+V+YLP LPGDYSILVKYN++HIPGS
Sbjct: 1874 TIVTEDAGEGGLDLAIEGPSKAEISCIDNKDGTCTVTYLPTLPGDYSILVKYNDKHIPGS 1933

Query: 639  PFTARVTGDDSMRMSHLKVGSAADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGH 818
            PFTA++T DDS R S +K+GSAAD  ++ISETDLS LTA++  PSGR+EPCLLKRL N H
Sbjct: 1934 PFTAKIT-DDSRRCSQVKLGSAADFLLDISETDLSSLTASIKAPSGRDEPCLLKRLPNNH 1992

Query: 819  VGISFVPKETGEHLVHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEGHTFEPA 998
            +GISF+P+E GEHLV +KKNG HVA+SP+ +++ QSEIGDA R +V GRGL EG TFE +
Sbjct: 1993 IGISFIPREVGEHLVSIKKNGNHVANSPVSIMVVQSEIGDARRAKVYGRGLSEGRTFEMS 2052

Query: 999  EFIIDTRDAGYGGLSLSIEGPSKVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVP 1178
            +FI+DTRDAGYGG+SL++EGPSKVDI TEDLEDGTC+V+Y PT PG YI++ KFAD+HVP
Sbjct: 2053 DFIVDTRDAGYGGISLAVEGPSKVDIQTEDLEDGTCKVSYFPTVPGVYIVSTKFADEHVP 2112

Query: 1179 GSPFSVKVTGEGRVKESITRRQRAPSVANVGSHCDLSLKIPEISIQDMTAQVTSPSGKSH 1358
            GSPF+VK++GEGRVKESITR  RAPSVA VGS CDL+LKIPEI+  DM+A VTSPSG+  
Sbjct: 2113 GSPFTVKISGEGRVKESITRTSRAPSVATVGSICDLNLKIPEINSSDMSAHVTSPSGRVT 2172

Query: 1359 EAEIVEGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGP 1538
            EAEIV    +++C+RFVP EMG+HTVSVKY+GQHV GSPFQFTVGPLGEGGAHKVRAGGP
Sbjct: 2173 EAEIVPMGKNSHCVRFVPQEMGVHTVSVKYRGQHVTGSPFQFTVGPLGEGGAHKVRAGGP 2232

Query: 1539 GLERAEAGVPAEFSIWTREAGAGGLAIAVEGPSKAEISFEDRKDGSCGVAYVVQEPGDYE 1718
            GLER EAGVPAEFSIWTREAGAGGL+IAVEGPSKAEI+F+D K+GSCGV+Y+ QEPG+YE
Sbjct: 2233 GLERGEAGVPAEFSIWTREAGAGGLSIAVEGPSKAEITFDDHKNGSCGVSYIAQEPGNYE 2292

Query: 1719 VSVKFNEEHIPDSPFVVPVASPSGDARRLTVSSLQESGLKVNQPASFAVSLNGAKGAIDA 1898
            VS+KFN+EHIP+SP++VPV +PS DARRLTV SLQESGLKVNQPASFA+ LNGAKG IDA
Sbjct: 2293 VSIKFNDEHIPESPYLVPVIAPSDDARRLTVMSLQESGLKVNQPASFAIRLNGAKGKIDA 2352

Query: 1899 KVHSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGHG 2078
            KVHSPSGA+EEC+V+E++ DKYAVRFIP ENGV+ IDVKFNG+H+ GSPFK+RVGEPG  
Sbjct: 2353 KVHSPSGAVEECHVSELEPDKYAVRFIPHENGVHTIDVKFNGSHVVGSPFKVRVGEPGQA 2412

Query: 2079 GDPGLVSAYGAGLEGGVTGSPAEFIVNTSNAGAGALSVTIDGPSKVKMDCQECPEGYRVT 2258
            G+P LVSAYG GLEGG TG  +EF +NT+ AG G LSVTI+GPSKVKMDCQE PEGY+V 
Sbjct: 2413 GNPALVSAYGTGLEGGTTGIQSEFFINTTRAGPGTLSVTIEGPSKVKMDCQETPEGYKVM 2472

Query: 2259 YTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSVFVDSLTKTXXXXX 2438
            YTPMAPG+YLIS+KYGGP HI GSPFKA+VTG RLVS  S +ETSS+ V+S+T++     
Sbjct: 2473 YTPMAPGNYLISVKYGGPNHIVGSPFKAKVTGQRLVSPGSANETSSILVESVTRSSTETC 2532

Query: 2439 XXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKAGNNMLLVGVHGPRTPCEEILV 2618
                       SKV +KG GLSKA+VGQK SF VDCSKAG+NMLL+GVHGP TPCEE+ +
Sbjct: 2533 YSAIPKASSDASKVTSKGAGLSKAFVGQKSSFLVDCSKAGSNMLLIGVHGPTTPCEEVSM 2592

Query: 2619 KHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLVP 2741
            KHVG++ Y+V+Y++K++G+Y L VKWG+EHIPGSP+ V VP
Sbjct: 2593 KHVGNQQYNVTYVVKERGDYVLAVKWGEEHIPGSPFHVTVP 2633



 Score =  429 bits (1103), Expect = e-120
 Identities = 288/900 (32%), Positives = 425/900 (47%), Gaps = 32/900 (3%)
 Frame = +3

Query: 135  GVNGLDVTSLRPFDLVIPFT-IKKGEITGEVRMPSGKVAQPAITDNKDGTVTVRYAPSEA 311
            G++   V +  P D  I      +G +  ++    GK  +  + DNKDGT  V Y P + 
Sbjct: 1557 GLSSYGVPASLPVDFAIDARDAGEGLLAVQITDQEGKPKRAIVHDNKDGTYAVTYIPDKT 1616

Query: 312  GLHEMDIRYDNMHIPGSPLQFYVDYV-NCGHVTAYGPGLSHGVVNKPAV-FTVNTKDAGE 485
            G + + + Y    IP SP +       +     A GPG++  V     V F V+ K AG+
Sbjct: 1617 GRYMIGVTYGGDDIPLSPYRIRATQTGDASKCLATGPGIASTVKTGEEVGFVVDAKTAGK 1676

Query: 486  GGLSLAIEGP--SKAEISCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARVT 659
            G ++  +  P  ++AE    +N+DGT  + Y    PG Y I V++    IP SPFT   T
Sbjct: 1677 GKVTCTVLTPDGTEAEADVIENEDGTYDIFYTAAKPGTYVIYVRFGGVDIPNSPFTVMAT 1736

Query: 660  GDDSMRMSHLKVGSA-----------ADIPIN------ISETDLSL--------LTATVV 764
              +   +    V +            A +P++          DL +        +T  V 
Sbjct: 1737 DGEVTAVEEAPVNACPPGFRPWVTEEAYVPVSDMNGLGFKPFDLVIPFAVRKGEITGEVH 1796

Query: 765  PPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNGQHVASSPIPVVISQSEIGDAS 944
             PSG+     +   ++G V + + P E G H +H+K  G H+  SP+   ++    G  S
Sbjct: 1797 MPSGKTATPEIVDNKDGTVTVRYAPTEVGLHEMHIKYMGSHIPESPLQFYVNYPNSGSVS 1856

Query: 945  RVRVSGRGLHEGHTFEPAEFIIDTRDAGYGGLSLSIEGPSKVDINTEDLEDGTCRVTYCP 1124
                 G GL  G   + A F I T DAG GGL L+IEGPSK +I+  D +DGTC VTY P
Sbjct: 1857 ---AYGPGLVYGVANKTATFTIVTEDAGEGGLDLAIEGPSKAEISCIDNKDGTCTVTYLP 1913

Query: 1125 TEPGNYIINIKFADQHVPGSPFSVKVTGEGRVKESITRRQRAPSVANVGSHCDLSLKIPE 1304
            T PG+Y I +K+ D+H+PGSPF+ K+T +           R  S   +GS  D  L I E
Sbjct: 1914 TLPGDYSILVKYNDKHIPGSPFTAKITDD----------SRRCSQVKLGSAADFLLDISE 1963

Query: 1305 ISIQDMTAQVTSPSGKSHEAEIVEGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQF 1484
              +  +TA + +PSG+     +    N+   I F+P E+G H VS+K  G HV  SP   
Sbjct: 1964 TDLSSLTASIKAPSGRDEPCLLKRLPNNHIGISFIPREVGEHLVSIKKNGNHVANSPVSI 2023

Query: 1485 TVGPLGEGGAHKVRAGGPGLERAEAGVPAEFSIWTREAGAGGLAIAVEGPSKAEISFEDR 1664
             V     G A + +  G GL        ++F + TR+AG GG+++AVEGPSK +I  ED 
Sbjct: 2024 MVVQSEIGDARRAKVYGRGLSEGRTFEMSDFIVDTRDAGYGGISLAVEGPSKVDIQTEDL 2083

Query: 1665 KDGSCGVAYVVQEPGDYEVSVKFNEEHIPDSPFVVPVASPSGDARRLTVSSLQESGLKVN 1844
            +DG+C V+Y    PG Y VS KF +EH+P SPF V ++        +T +S   S   V 
Sbjct: 2084 EDGTCKVSYFPTVPGVYIVSTKFADEHVPGSPFTVKISGEGRVKESITRTSRAPSVATVG 2143

Query: 1845 QPASFAVSLNGAKGA-IDAKVHSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFN 2021
                  + +     + + A V SPSG + E  +  + ++ + VRF+P+E GV+ + VK+ 
Sbjct: 2144 SICDLNLKIPEINSSDMSAHVTSPSGRVTEAEIVPMGKNSHCVRFVPQEMGVHTVSVKYR 2203

Query: 2022 GTHIPGSPFKIRVGEPGHGGDPGLVSAYGAGLEGGVTGSPAEFIVNTSNAGAGALSVTID 2201
            G H+ GSPF+  VG  G GG    V A G GLE G  G PAEF + T  AGAG LS+ ++
Sbjct: 2204 GQHVTGSPFQFTVGPLGEGG-AHKVRAGGPGLERGEAGVPAEFSIWTREAGAGGLSIAVE 2262

Query: 2202 GPSKVKMDCQECPEG-YRVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHS 2378
            GPSK ++   +   G   V+Y    PG+Y +SIK+    HI  SP+   V          
Sbjct: 2263 GPSKAEITFDDHKNGSCGVSYIAQEPGNYEVSIKFNDE-HIPESPYLVPVIA-------- 2313

Query: 2379 LHETSSVFVDSLTKTXXXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKAG 2558
                                            ++    L  S   V Q  SF +  + A 
Sbjct: 2314 --------------------------PSDDARRLTVMSLQESGLKVNQPASFAIRLNGA- 2346

Query: 2559 NNMLLVGVHGPRTPCEEILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLV 2738
               +   VH P    EE  V  +    Y+V ++  + G +T+ VK+   H+ GSP++V V
Sbjct: 2347 KGKIDAKVHSPSGAVEECHVSELEPDKYAVRFIPHENGVHTIDVKFNGSHVVGSPFKVRV 2406



 Score =  323 bits (828), Expect = 6e-88
 Identities = 240/787 (30%), Positives = 369/787 (46%), Gaps = 70/787 (8%)
 Frame = +3

Query: 201  KGEITGEVRMPSGKVAQPAITD--NKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQF 374
            +G++   +  PS KV    +T    ++ + T ++ P E GL+ +D+ YD   +PGSP   
Sbjct: 974  QGKLDVTILSPSRKVVPCLVTPVTGRENS-TAKFIPREEGLYAVDVTYDGHPVPGSPYTV 1032

Query: 375  YVDYV-NCGHVTAYGPGLSHGVVNKPAVFTVNTKDAGEGGLSLAIEGPSKAEISCTDNQD 551
                  +   V A+GPGL  G+V KPA FT++TK AG GGL L +EGP +A+I C+DN D
Sbjct: 1033 EASLPPDPSKVKAHGPGLEGGLVGKPAEFTIDTKGAGTGGLGLTVEGPCEAKIECSDNGD 1092

Query: 552  GTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARV--------TGDDSMRMSHLKVGSAA 707
            GTCSVSYLP  PG+Y + + + E HIPGSPF A +               + H KVG A 
Sbjct: 1093 GTCSVSYLPTKPGEYFVNILFEEVHIPGSPFKADIEMPFDPSKVVASGPGLEHGKVGEAG 1152

Query: 708  DIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNGQH 887
             + ++ SE     L    V  SG +    ++  ++G   +++VP   G + + +K  G+ 
Sbjct: 1153 LLSVDCSEAGPGALGLEAVSDSGTKAEVSIQNNKDGTYAVTYVPLTAGMYTLTMKYGGEL 1212

Query: 888  VASSPIPVVISQSEIGDASRVRVSGRGLHEGHTFEPA--EFIIDTR---DAGYGGLSLSI 1052
            V   P  V +  +   D SR++V G G+     F  A  +F +D+R     G   +   I
Sbjct: 1213 VPHFPARVKVEPAV--DTSRIKVFGPGIEGKDVFREATTDFTVDSRPLTQVGGDHIKAHI 1270

Query: 1053 EGPS--KVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVT------- 1205
              PS    +    D  DGT +V Y P E G +++ + + D  +P SPF V VT       
Sbjct: 1271 ANPSGASTECFVTDNADGTYQVEYTPFEKGLHVVEVTYDDVPIPNSPFKVAVTEGCQPSR 1330

Query: 1206 ----GEGRVKESITRRQRAPSVANVGSHCDLSLKIPEISIQDMTAQVTSPSGKSHEAEIV 1373
                G G +KE+ T +    +V   G+            I  +   V  PS    +    
Sbjct: 1331 VQAQGPG-LKEAFTNKPNVFTVVTRGA-----------GIGGLGITVEGPS--ESKINCR 1376

Query: 1374 EGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGL-ER 1550
            + ++ +    ++P   G + V++ Y G H+PGSPF+  V  + +    KV+  GPGL   
Sbjct: 1377 DNKDGSCSAEYIPFAPGDYDVNITYGGAHIPGSPFRVPVKDVVD--PSKVKIAGPGLGSG 1434

Query: 1551 AEAGVPAEFSIWTREAGAGGLAIAVEGPSKAE---------------------------- 1646
              A V   F++ + +AG   L + V GP   +                            
Sbjct: 1435 VRARVLQSFTVDSSKAGLAPLEVRVLGPRADDTDSQSWRSPLKALSEFFKGDPKGDFNKT 1494

Query: 1647 -----ISFEDRKDGSCGVAYVVQEPGDYEVSVKFNEEHIPDSPFVVPVASPSGDARRLTV 1811
                 ++  D  DG+  V Y   + G Y VSVK+ +E IP SPF V V  P+ DA ++T 
Sbjct: 1495 GLVEPVNVVDNGDGTHTVTYTPSQEGPYMVSVKYADEEIPRSPFKVKVL-PTYDASKVTA 1553

Query: 1812 S--SLQESGLKVNQPASFAVSLNGA-KGAIDAKVHSPSGALEECYVTEIDQDKYAVRFIP 1982
            S   L   G+  + P  FA+    A +G +  ++    G  +   V +     YAV +IP
Sbjct: 1554 SGPGLSSYGVPASLPVDFAIDARDAGEGLLAVQITDQEGKPKRAIVHDNKDGTYAVTYIP 1613

Query: 1983 RENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPGLVSAYGAGLEGGV-TGSPAEFIVN 2159
             + G Y+I V + G  IP SP++IR  +    GD     A G G+   V TG    F+V+
Sbjct: 1614 DKTGRYMIGVTYGGDDIPLSPYRIRATQT---GDASKCLATGPGIASTVKTGEEVGFVVD 1670

Query: 2160 TSNAGAGALSVTIDGP--SKVKMDCQECPEG-YRVTYTPMAPGSYLISIKYGGPYHIGGS 2330
               AG G ++ T+  P  ++ + D  E  +G Y + YT   PG+Y+I +++GG   I  S
Sbjct: 1671 AKTAGKGKVTCTVLTPDGTEAEADVIENEDGTYDIFYTAAKPGTYVIYVRFGG-VDIPNS 1729

Query: 2331 PFKARVT 2351
            PF    T
Sbjct: 1730 PFTVMAT 1736



 Score =  323 bits (828), Expect = 6e-88
 Identities = 270/944 (28%), Positives = 401/944 (42%), Gaps = 76/944 (8%)
 Frame = +3

Query: 135  GVNGLDVTSLRPFDLVI---PFTIKKGE-ITGEVRMPSGKVAQPAITDNKDGTVTVRYAP 302
            G+ G DV      D  +   P T   G+ I   +  PSG   +  +TDN DGT  V Y P
Sbjct: 1237 GIEGKDVFREATTDFTVDSRPLTQVGGDHIKAHIANPSGASTECFVTDNADGTYQVEYTP 1296

Query: 303  SEAGLHEMDIRYDNMHIPGSPLQFYV-DYVNCGHVTAYGPGLSHGVVNKPAVFTVNTKDA 479
             E GLH +++ YD++ IP SP +  V +      V A GPGL     NKP VFTV T+ A
Sbjct: 1297 FEKGLHVVEVTYDDVPIPNSPFKVAVTEGCQPSRVQAQGPGLKEAFTNKPNVFTVVTRGA 1356

Query: 480  GEGGLSLAIEGPSKAEISCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARVT 659
            G GGL + +EGPS+++I+C DN+DG+CS  Y+P  PGDY + + Y   HIPGSPF  RV 
Sbjct: 1357 GIGGLGITVEGPSESKINCRDNKDGSCSAEYIPFAPGDYDVNITYGGAHIPGSPF--RVP 1414

Query: 660  GDDSMRMSHLKVGSAA-----------DIPINISETDLSLLTATVVPP------------ 770
              D +  S +K+                  ++ S+  L+ L   V+ P            
Sbjct: 1415 VKDVVDPSKVKIAGPGLGSGVRARVLQSFTVDSSKAGLAPLEVRVLGPRADDTDSQSWRS 1474

Query: 771  -------------------SGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNGQHVA 893
                               +G  EP  +    +G   +++ P + G ++V VK   + + 
Sbjct: 1475 PLKALSEFFKGDPKGDFNKTGLVEPVNVVDNGDGTHTVTYTPSQEGPYMVSVKYADEEIP 1534

Query: 894  SSPIPVVISQSEIGDASRVRVSGRGL--HEGHTFEPAEFIIDTRDAGYGGLSLSI---EG 1058
             SP  V +  +   DAS+V  SG GL  +      P +F ID RDAG G L++ I   EG
Sbjct: 1535 RSPFKVKVLPTY--DASKVTASGPGLSSYGVPASLPVDFAIDARDAGEGLLAVQITDQEG 1592

Query: 1059 PSKVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTGEGRVKESITR 1238
              K  I   D +DGT  VTY P + G Y+I + +    +P SP+ ++ T  G   + +  
Sbjct: 1593 KPKRAI-VHDNKDGTYAVTYIPDKTGRYMIGVTYGGDDIPLSPYRIRATQTGDASKCLAT 1651

Query: 1239 RQRAPSVANVGSHCDLSLKIPEISIQDMTAQVTSPSGKSHEAEIVEGENHTYCIRFVPAE 1418
                 S    G      +         +T  V +P G   EA+++E E+ TY I +  A+
Sbjct: 1652 GPGIASTVKTGEEVGFVVDAKTAGKGKVTCTVLTPDGTEAEADVIENEDGTYDIFYTAAK 1711

Query: 1419 MGMHTVSVKYKGQHVPGSPF--QFTVGPLGEGGAHKVRAGGPGLE---RAEAGVPAE--- 1574
             G + + V++ G  +P SPF    T G +       V A  PG       EA VP     
Sbjct: 1712 PGTYVIYVRFGGVDIPNSPFTVMATDGEVTAVEEAPVNACPPGFRPWVTEEAYVPVSDMN 1771

Query: 1575 ------FSIWTREA-GAGGLAIAVEGPS--KAEISFEDRKDGSCGVAYVVQEPGDYEVSV 1727
                  F +    A   G +   V  PS   A     D KDG+  V Y   E G +E+ +
Sbjct: 1772 GLGFKPFDLVIPFAVRKGEITGEVHMPSGKTATPEIVDNKDGTVTVRYAPTEVGLHEMHI 1831

Query: 1728 KFNEEHIPDSPFVVPVASPSGDARRLTVSSLQESGL---KVNQPASFA-VSLNGAKGAID 1895
            K+   HIP+SP    V  P+  +      S    GL     N+ A+F  V+ +  +G +D
Sbjct: 1832 KYMGSHIPESPLQFYVNYPNSGS-----VSAYGPGLVYGVANKTATFTIVTEDAGEGGLD 1886

Query: 1896 AKVHSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGH 2075
              +  PS A   C   +       V ++P   G Y I VK+N  HIPGSPF  ++ +   
Sbjct: 1887 LAIEGPSKAEISC--IDNKDGTCTVTYLPTLPGDYSILVKYNDKHIPGSPFTAKITDDSR 1944

Query: 2076 GGDPGLVSAYGAGLEGGVTGSPAEFIVNTSNAGAGALSVTIDGPSKVKMDC--QECPEGY 2249
                  +            GS A+F+++ S     +L+ +I  PS     C  +  P  +
Sbjct: 1945 RCSQVKL------------GSAADFLLDISETDLSSLTASIKAPSGRDEPCLLKRLPNNH 1992

Query: 2250 -RVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSVFVDSLTKTX 2426
              +++ P   G +L+SIK  G  H+  SP    V    +                     
Sbjct: 1993 IGISFIPREVGEHLVSIKKNG-NHVANSPVSIMVVQSEI--------------------- 2030

Query: 2427 XXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKAGNNMLLVGVHGPRTPCE 2606
                            +    G GLS+    +   F VD   AG   + + V GP     
Sbjct: 2031 ------------GDARRAKVYGRGLSEGRTFEMSDFIVDTRDAGYGGISLAVEGPSK--V 2076

Query: 2607 EILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLV 2738
            +I  + +      VSY     G Y +  K+ DEH+PGSP+ V +
Sbjct: 2077 DIQTEDLEDGTCKVSYFPTVPGVYIVSTKFADEHVPGSPFTVKI 2120



 Score =  297 bits (760), Expect = 5e-80
 Identities = 261/904 (28%), Positives = 388/904 (42%), Gaps = 68/904 (7%)
 Frame = +3

Query: 228  MPSGKVAQPAITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFYVDY-VNCGHV 404
            +P   V    I DN D + TV+Y P++ G  ++ + Y    IP SP    V   ++   +
Sbjct: 888  LPGDAVKDLDIIDNYDYSHTVKYTPTQQGNMQVLVTYGGDPIPKSPFTVGVAAPLDLSKI 947

Query: 405  TAYGPGLSHGV-VNKPAVFTVNTKDAG-EGGLSLAIEGPSKAEISC-----TDNQDGTCS 563
               G  L + V V K   FTV+T+ AG +G L + I  PS+  + C     T  ++ T  
Sbjct: 948  KLNG--LENRVEVGKDQEFTVDTRGAGGQGKLDVTILSPSRKVVPCLVTPVTGRENSTAK 1005

Query: 564  VSYLPVLPGDYSILVKYNEQHIPGSPFT--ARVTGDDSMRMSHLK------VGSAADIPI 719
              ++P   G Y++ V Y+   +PGSP+T  A +  D S   +H        VG  A+  I
Sbjct: 1006 --FIPREEGLYAVDVTYDGHPVPGSPYTVEASLPPDPSKVKAHGPGLEGGLVGKPAEFTI 1063

Query: 720  NISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNGQHVASS 899
            +        L  TV  P   +  C      +G   +S++P + GE+ V++     H+  S
Sbjct: 1064 DTKGAGTGGLGLTVEGPCEAKIEC--SDNGDGTCSVSYLPTKPGEYFVNILFEEVHIPGS 1121

Query: 900  PIPVVISQSEIGDASRVRVSGRGLHEGHTFEPAEFIIDTRDAGYGGLSLSIEGPS--KVD 1073
            P    I      D S+V  SG GL  G   E     +D  +AG G L L     S  K +
Sbjct: 1122 PFKADIEMPF--DPSKVVASGPGLEHGKVGEAGLLSVDCSEAGPGALGLEAVSDSGTKAE 1179

Query: 1074 INTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVT-----------GEGRV 1220
            ++ ++ +DGT  VTY P   G Y + +K+  + VP  P  VKV            G G  
Sbjct: 1180 VSIQNNKDGTYAVTYVPLTAGMYTLTMKYGGELVPHFPARVKVEPAVDTSRIKVFGPGIE 1239

Query: 1221 KESITRRQRAPSVANVGSHCDLSLKIPEISIQDMTAQVTSPSGKSHEAEIVEGENHTYCI 1400
             + + R        +       S  + ++    + A + +PSG S E  + +  + TY +
Sbjct: 1240 GKDVFREATTDFTVD-------SRPLTQVGGDHIKAHIANPSGASTECFVTDNADGTYQV 1292

Query: 1401 RFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEG-GAHKVRAGGPGLERAEAGVPAEF 1577
             + P E G+H V V Y    +P SPF+  V    EG    +V+A GPGL+ A    P  F
Sbjct: 1293 EYTPFEKGLHVVEVTYDDVPIPNSPFKVAVT---EGCQPSRVQAQGPGLKEAFTNKPNVF 1349

Query: 1578 SIWTREAGAGGLAIAVEGPSKAEISFEDRKDGSCGVAYVVQEPGDYEVSVKFNEEHIPDS 1757
            ++ TR AG GGL I VEGPS+++I+  D KDGSC   Y+   PGDY+V++ +   HIP S
Sbjct: 1350 TVVTRGAGIGGLGITVEGPSESKINCRDNKDGSCSAEYIPFAPGDYDVNITYGGAHIPGS 1409

Query: 1758 PFVVPVASPSGDARRLTVSSLQESGLKVNQPASFAV-SLNGAKGAIDAKVHSP------- 1913
            PF VPV      ++         SG++     SF V S       ++ +V  P       
Sbjct: 1410 PFRVPVKDVVDPSKVKIAGPGLGSGVRARVLQSFTVDSSKAGLAPLEVRVLGPRADDTDS 1469

Query: 1914 ------------------------SGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFN 2021
                                    +G +E   V +     + V + P + G Y++ VK+ 
Sbjct: 1470 QSWRSPLKALSEFFKGDPKGDFNKTGLVEPVNVVDNGDGTHTVTYTPSQEGPYMVSVKYA 1529

Query: 2022 GTHIPGSPFKIRVGEPGHGGDPGLVSAYGAGLEG-GVTGS-PAEFIVNTSNAGAGALSVT 2195
               IP SPFK++V  P +  D   V+A G GL   GV  S P +F ++  +AG G L+V 
Sbjct: 1530 DEEIPRSPFKVKV-LPTY--DASKVTASGPGLSSYGVPASLPVDFAIDARDAGEGLLAVQ 1586

Query: 2196 I---DGPSKVKMDCQECPEGYRVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLV 2366
            I   +G  K  +        Y VTY P   G Y+I + YGG   I  SP++ R T     
Sbjct: 1587 ITDQEGKPKRAIVHDNKDGTYAVTYIPDKTGRYMIGVTYGGD-DIPLSPYRIRAT----- 1640

Query: 2367 SNHSLHETSSVFVDSLTKTXXXXXXXXXXXXXXXXSKVLAKGLGL-SKAYVGQKGSFTVD 2543
                  +T                           SK LA G G+ S    G++  F VD
Sbjct: 1641 ------QTGDA------------------------SKCLATGPGIASTVKTGEEVGFVVD 1670

Query: 2544 CSKAGNNMLLVGVHGPRTPCEEILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSP 2723
               AG   +   V  P     E  V       Y + Y     G Y + V++G   IP SP
Sbjct: 1671 AKTAGKGKVTCTVLTPDGTEAEADVIENEDGTYDIFYTAAKPGTYVIYVRFGGVDIPNSP 1730

Query: 2724 YRVL 2735
            + V+
Sbjct: 1731 FTVM 1734



 Score =  292 bits (747), Expect = 1e-78
 Identities = 253/885 (28%), Positives = 387/885 (43%), Gaps = 52/885 (5%)
 Frame = +3

Query: 264  DNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFYVDYVNCGH----VTAYGPGLSH 431
            D  DG+  V+Y P E G + + I  D+  I  SP   ++     G+    V AYGPGL  
Sbjct: 598  DQNDGSCDVKYWPKEPGEYAVHIMCDDEDIKDSPYMAFIHPATGGYNPDLVRAYGPGLEK 657

Query: 432  G--VVNKPAVFTVNTKDAGEGGLSL-AIEGPS-KAEISCTDNQDGTCSVSYLPVLPGDYS 599
               +VN  A FTV+ KDAG+  L + A +G   + +I   +  DGT + SY PV    ++
Sbjct: 658  SGCIVNNLAEFTVDPKDAGKAPLKIFAQDGEGQRIDIQMKNRMDGTYACSYTPVKAIKHT 717

Query: 600  ILVKYNEQHIPGSPFTARVTGDDS-----------MRMSHLKVGSAADIPINISET---D 737
            I V +   +IP SP+   + G  S           +  S LK        ++ +E    D
Sbjct: 718  IAVVWGGVNIPHSPYRVNI-GQGSHPQKVKVFGPGVERSGLKANEPTHFTVDCTEAGEGD 776

Query: 738  LSL---LTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNGQHVASSPIP 908
            +S+     A V+     +    +    N    + +VP   G + + V    Q + +SP  
Sbjct: 777  VSVGIKCDARVLSEDEEDVDFDIIHNANDTFTVKYVPPAAGRYTIKVLFASQEIPASPFR 836

Query: 909  VVISQSEIGDASRVRVSGRGLHEG--HTFEPAEFIIDTRDAGYGGLSLSIEGP----SKV 1070
            V +  S   DAS+V+  G GL +      +P  F + T+ AG   L++    P    +  
Sbjct: 837  VKVDPSH--DASKVKAEGPGLSKAGVENGKPTHFTVYTKGAGKAPLNVQFNSPLPGDAVK 894

Query: 1071 DINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTG------------EG 1214
            D++  D  D +  V Y PT+ GN  + + +    +P SPF+V V              E 
Sbjct: 895  DLDIIDNYDYSHTVKYTPTQQGNMQVLVTYGGDPIPKSPFTVGVAAPLDLSKIKLNGLEN 954

Query: 1215 RVKESITRRQRAPSVANVGSHCDLSLKIPEISIQDMTAQVTSPSGKSHEAEIVEGENHTY 1394
            RV+     ++        G    L + I   S + +   VT  +G+         EN T 
Sbjct: 955  RVEVG-KDQEFTVDTRGAGGQGKLDVTILSPSRKVVPCLVTPVTGR---------ENST- 1003

Query: 1395 CIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLERAEAGVPAE 1574
              +F+P E G++ V V Y G  VPGSP+  TV         KV+A GPGLE    G PAE
Sbjct: 1004 -AKFIPREEGLYAVDVTYDGHPVPGSPY--TVEASLPPDPSKVKAHGPGLEGGLVGKPAE 1060

Query: 1575 FSIWTREAGAGGLAIAVEGPSKAEISFEDRKDGSCGVAYVVQEPGDYEVSVKFNEEHIPD 1754
            F+I T+ AG GGL + VEGP +A+I   D  DG+C V+Y+  +PG+Y V++ F E HIP 
Sbjct: 1061 FTIDTKGAGTGGLGLTVEGPCEAKIECSDNGDGTCSVSYLPTKPGEYFVNILFEEVHIPG 1120

Query: 1755 SPFVVPVASPSGDARRLTVSSLQESGLKVNQPASFAVSLNGA-KGAIDAKVHSPSGALEE 1931
            SPF   +  P   ++ +      E G KV +    +V  + A  GA+  +  S SG   E
Sbjct: 1121 SPFKADIEMPFDPSKVVASGPGLEHG-KVGEAGLLSVDCSEAGPGALGLEAVSDSGTKAE 1179

Query: 1932 CYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPGLVSAYGA 2111
              +       YAV ++P   G+Y + +K+ G  +P  P +++V EP    D   +  +G 
Sbjct: 1180 VSIQNNKDGTYAVTYVPLTAGMYTLTMKYGGELVPHFPARVKV-EP--AVDTSRIKVFGP 1236

Query: 2112 GLEGG--VTGSPAEFIVNT---SNAGAGALSVTIDGPSKVKMDC---QECPEGYRVTYTP 2267
            G+EG      +  +F V++   +  G   +   I  PS    +C         Y+V YTP
Sbjct: 1237 GIEGKDVFREATTDFTVDSRPLTQVGGDHIKAHIANPSGASTECFVTDNADGTYQVEYTP 1296

Query: 2268 MAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSVFVDSLTKTXXXXXXXX 2447
               G +++ + Y     I  SPFK  VT                                
Sbjct: 1297 FEKGLHVVEVTY-DDVPIPNSPFKVAVT-------------------------------- 1323

Query: 2448 XXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKAGNNMLLVGVHGPRTPCEEILVKHV 2627
                    S+V A+G GL +A+  +   FTV    AG   L + V GP     +I  +  
Sbjct: 1324 ---EGCQPSRVQAQGPGLKEAFTNKPNVFTVVTRGAGIGGLGITVEGPSE--SKINCRDN 1378

Query: 2628 GSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLVP*ALCPGQ 2762
                 S  Y+    G+Y + + +G  HIPGSP+RV V   + P +
Sbjct: 1379 KDGSCSAEYIPFAPGDYDVNITYGGAHIPGSPFRVPVKDVVDPSK 1423



 Score =  290 bits (741), Expect = 7e-78
 Identities = 239/892 (26%), Positives = 380/892 (42%), Gaps = 49/892 (5%)
 Frame = +3

Query: 201  KGEITGEVRMPSGKVAQPAIT--DNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQF 374
            +G++   V  P G   +  +T   +K+ T +V Y P   GLH++ + +   HI  SP + 
Sbjct: 286  QGDVMVFVEDPEGNKEEAQVTPDSDKNKTYSVEYLPKVTGLHKVTVLFAGQHISKSPFEV 345

Query: 375  YVDYV--NCGHVTAYGPGLS--HGVVNKPAVFTVNTKDAGEGGLSLAIEGP---SKAEIS 533
             VD    +   VTA GPGL     + NKP  F + T  AG G + + +E P   +  E+ 
Sbjct: 346  SVDKAQGDASKVTAKGPGLEAVGNIANKPTYFDIYTAGAGVGDIGVEVEDPQGKNTVELL 405

Query: 534  CTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARV----------TGDDSMRMS 683
              D  +      Y P+ PG + + + +    IP SPF  +V               ++  
Sbjct: 406  VEDKGNQVYRCVYKPMQPGPHVVKIFFAGDTIPKSPFVVQVGEACNPNACRASGRGLQPK 465

Query: 684  HLKVGSAADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLV 863
             +++    D  ++        L  T+  P G EE    K   +G     + P   G + +
Sbjct: 466  GVRIRETTDFKVDTKAAGSGELGVTMKGPKGLEELVKQKDFLDGVYAFEYYPSTPGRYSI 525

Query: 864  HVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEGHTFEPAEFIIDTRDAGYGGLS 1043
             +   G H+  SP  V +         +VR  G GLH G     A+F++++  +  G L 
Sbjct: 526  AITWGGHHIPKSPFEVQVGPE--AGMQKVRAWGPGLHGGIVGRSADFVVESIGSEVGSLG 583

Query: 1044 LSIEGPSKVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKV-TGEGRV 1220
             +IEGPS+  I   D  DG+C V Y P EPG Y ++I   D+ +  SP+   +    G  
Sbjct: 584  FAIEGPSQAKIEYNDQNDGSCDVKYWPKEPGEYAVHIMCDDEDIKDSPYMAFIHPATGGY 643

Query: 1221 KESITRRQ---RAPSVANVGSHCDLSLKIPEISIQDMTAQVTSPSGKSHEAEIVEGENHT 1391
               + R        S   V +  + ++   +     +        G+  + ++    + T
Sbjct: 644  NPDLVRAYGPGLEKSGCIVNNLAEFTVDPKDAGKAPLKIFAQDGEGQRIDIQMKNRMDGT 703

Query: 1392 YCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAH--KVRAGGPGLERA--EA 1559
            Y   + P +   HT++V + G ++P SP++  +G     G+H  KV+  GPG+ER+  +A
Sbjct: 704  YACSYTPVKAIKHTIAVVWGGVNIPHSPYRVNIGQ----GSHPQKVKVFGPGVERSGLKA 759

Query: 1560 GVPAEFSIWTREAGAGGLAIAVEGPSKAEISFEDRKD----------GSCGVAYVVQEPG 1709
              P  F++   EAG G +++ ++    A +  ED +D           +  V YV    G
Sbjct: 760  NEPTHFTVDCTEAGEGDVSVGIK--CDARVLSEDEEDVDFDIIHNANDTFTVKYVPPAAG 817

Query: 1710 DYEVSVKFNEEHIPDSPFVVPVASPSGDARRLTVS--SLQESGLKVNQPASFAVSLNGA- 1880
             Y + V F  + IP SPF V V  PS DA ++      L ++G++  +P  F V   GA 
Sbjct: 818  RYTIKVLFASQEIPASPFRVKV-DPSHDASKVKAEGPGLSKAGVENGKPTHFTVYTKGAG 876

Query: 1881 KGAIDAKVHS--PSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKI 2054
            K  ++ + +S  P  A+++  + +     + V++ P + G   + V + G  IP SPF +
Sbjct: 877  KAPLNVQFNSPLPGDAVKDLDIIDNYDYSHTVKYTPTQQGNMQVLVTYGGDPIPKSPFTV 936

Query: 2055 RVGEPGHGGDPGLVSAYGAGLEGGV-TGSPAEFIVNTSNAGA-GALSVTIDGPSKVKMDC 2228
             V  P       L      GLE  V  G   EF V+T  AG  G L VTI  PS+  + C
Sbjct: 937  GVAAP-----LDLSKIKLNGLENRVEVGKDQEFTVDTRGAGGQGKLDVTILSPSRKVVPC 991

Query: 2229 QECP----EGYRVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSS 2396
               P    E     + P   G Y + + Y G + + GSP+    +               
Sbjct: 992  LVTPVTGRENSTAKFIPREEGLYAVDVTYDG-HPVPGSPYTVEAS--------------- 1035

Query: 2397 VFVDSLTKTXXXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKAGNNMLLV 2576
                                     SKV A G GL    VG+   FT+D   AG   L +
Sbjct: 1036 --------------------LPPDPSKVKAHGPGLEGGLVGKPAEFTIDTKGAGTGGLGL 1075

Query: 2577 GVHGPRTPCE-EILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYR 2729
             V G   PCE +I     G    SVSYL    GEY + + + + HIPGSP++
Sbjct: 1076 TVEG---PCEAKIECSDNGDGTCSVSYLPTKPGEYFVNILFEEVHIPGSPFK 1124



 Score =  283 bits (723), Expect = 9e-76
 Identities = 247/888 (27%), Positives = 379/888 (42%), Gaps = 43/888 (4%)
 Frame = +3

Query: 204  GEITGEVRMPSGKVAQPAITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFYVD 383
            GE+   ++ P G        D  DG     Y PS  G + + I +   HIP SP +  V 
Sbjct: 485  GELGVTMKGPKGLEELVKQKDFLDGVYAFEYYPSTPGRYSIAITWGGHHIPKSPFEVQVG 544

Query: 384  -YVNCGHVTAYGPGLSHGVVNKPAVFTVNTKDAGEGGLSLAIEGPSKAEISCTDNQDGTC 560
                   V A+GPGL  G+V + A F V +  +  G L  AIEGPS+A+I   D  DG+C
Sbjct: 545  PEAGMQKVRAWGPGLHGGIVGRSADFVVESIGSEVGSLGFAIEGPSQAKIEYNDQNDGSC 604

Query: 561  SVSYLPVLPGDYSILVKYNEQHIPGSPFTARV---TG----------DDSMRMSHLKVGS 701
             V Y P  PG+Y++ +  +++ I  SP+ A +   TG             +  S   V +
Sbjct: 605  DVKYWPKEPGEYAVHIMCDDEDIKDSPYMAFIHPATGGYNPDLVRAYGPGLEKSGCIVNN 664

Query: 702  AADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNG 881
             A+  ++  +   + L        G+     +K   +G    S+ P +  +H + V   G
Sbjct: 665  LAEFTVDPKDAGKAPLKIFAQDGEGQRIDIQMKNRMDGTYACSYTPVKAIKHTIAVVWGG 724

Query: 882  QHVASSPIPVVISQSEIGDASRVRVSGRGLHEG--HTFEPAEFIIDTRDAGYGGLSLSIE 1055
             ++  SP  V I Q       +V+V G G+        EP  F +D  +AG G +S+ I+
Sbjct: 725  VNIPHSPYRVNIGQG--SHPQKVKVFGPGVERSGLKANEPTHFTVDCTEAGEGDVSVGIK 782

Query: 1056 GPSKVDINTEDLED----------GTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVT 1205
              ++V   +ED ED           T  V Y P   G Y I + FA Q +P SPF VKV 
Sbjct: 783  CDARV--LSEDEEDVDFDIIHNANDTFTVKYVPPAAGRYTIKVLFASQEIPASPFRVKVD 840

Query: 1206 ---GEGRVKESITRRQRAPSVANVGSHCDLSLKIPEISIQDMTAQVTSPSGKSHEAEIVE 1376
                  +VK       +A       +H  +  K    +  ++      P     + +I++
Sbjct: 841  PSHDASKVKAEGPGLSKAGVENGKPTHFTVYTKGAGKAPLNVQFNSPLPGDAVKDLDIID 900

Query: 1377 GENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLE-RA 1553
              ++++ +++ P + G   V V Y G  +P SP  FTVG        K++    GLE R 
Sbjct: 901  NYDYSHTVKYTPTQQGNMQVLVTYGGDPIPKSP--FTVGVAAPLDLSKIKLN--GLENRV 956

Query: 1554 EAGVPAEFSIWTREAGA-GGLAIAVEGPSKAEI-----SFEDRKDGSCGVAYVVQEPGDY 1715
            E G   EF++ TR AG  G L + +  PS+  +         R++ +    ++ +E G Y
Sbjct: 957  EVGKDQEFTVDTRGAGGQGKLDVTILSPSRKVVPCLVTPVTGRENST--AKFIPREEGLY 1014

Query: 1716 EVSVKFNEEHIPDSPFVVPVASPSGDARRLTVSSLQESGLKVNQPASFAVSLNGA-KGAI 1892
             V V ++   +P SP+ V  + P   ++        E GL V +PA F +   GA  G +
Sbjct: 1015 AVDVTYDGHPVPGSPYTVEASLPPDPSKVKAHGPGLEGGL-VGKPAEFTIDTKGAGTGGL 1073

Query: 1893 DAKVHSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPG 2072
               V  P  A  EC  ++      +V ++P + G Y +++ F   HIPGSPFK  +  P 
Sbjct: 1074 GLTVEGPCEAKIEC--SDNGDGTCSVSYLPTKPGEYFVNILFEEVHIPGSPFKADIEMP- 1130

Query: 2073 HGGDPGLVSAYGAGLEGGVTGSPAEFIVNTSNAGAGALSV--TIDGPSKVKMDCQECPEG 2246
               DP  V A G GLE G  G      V+ S AG GAL +    D  +K ++  Q   +G
Sbjct: 1131 --FDPSKVVASGPGLEHGKVGEAGLLSVDCSEAGPGALGLEAVSDSGTKAEVSIQNNKDG 1188

Query: 2247 -YRVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSVFVDSLTKT 2423
             Y VTY P+  G Y +++KYGG        F ARV     V      +TS +        
Sbjct: 1189 TYAVTYVPLTAGMYTLTMKYGGEL---VPHFPARVKVEPAV------DTSRI-------- 1231

Query: 2424 XXXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVD---CSKAGNNMLLVGVHGPR 2594
                             KV   G+     +      FTVD    ++ G + +   +  P 
Sbjct: 1232 -----------------KVFGPGIEGKDVFREATTDFTVDSRPLTQVGGDHIKAHIANPS 1274

Query: 2595 TPCEEILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLV 2738
                E  V       Y V Y   +KG + + V + D  IP SP++V V
Sbjct: 1275 GASTECFVTDNADGTYQVEYTPFEKGLHVVEVTYDDVPIPNSPFKVAV 1322



 Score =  229 bits (583), Expect = 2e-59
 Identities = 234/840 (27%), Positives = 368/840 (43%), Gaps = 47/840 (5%)
 Frame = +3

Query: 354  PGSPLQFYVDYVNCGHVTAYGPGL--SHGVVNKPAVFTVNTKDAGEGGLSLAIEGP---- 515
            PG+PL+     +N     AYG G+  +  +V +PA FTV+T  AG+G + + +E P    
Sbjct: 244  PGAPLK---PKLNPKKARAYGRGIEPTGNMVKQPAKFTVDTISAGQGDVMVFVEDPEGNK 300

Query: 516  SKAEISCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARV---TGDDSMRMSH 686
             +A+++   +++ T SV YLP + G + + V +  QHI  SPF   V    GD S   + 
Sbjct: 301  EEAQVTPDSDKNKTYSVEYLPKVTGLHKVTVLFAGQHISKSPFEVSVDKAQGDASKVTAK 360

Query: 687  ----LKVGSAADIP----INISETDLSLLTATVVPPSGREEPCLLKRLRNGHV-GISFVP 839
                  VG+ A+ P    I  +   +  +   V  P G+    LL   +   V    + P
Sbjct: 361  GPGLEAVGNIANKPTYFDIYTAGAGVGDIGVEVEDPQGKNTVELLVEDKGNQVYRCVYKP 420

Query: 840  KETGEHLVHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEG--HTFEPAEFIID 1013
             + G H+V +   G  +  SP   V+   E  + +  R SGRGL        E  +F +D
Sbjct: 421  MQPGPHVVKIFFAGDTIPKSPF--VVQVGEACNPNACRASGRGLQPKGVRIRETTDFKVD 478

Query: 1014 TRDAGYGGLSLSIEGPSKVD--INTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSP 1187
            T+ AG G L ++++GP  ++  +  +D  DG     Y P+ PG Y I I +   H+P SP
Sbjct: 479  TKAAGSGELGVTMKGPKGLEELVKQKDFLDGVYAFEYYPSTPGRYSIAITWGGHHIPKSP 538

Query: 1188 FSVKVTGEGRVKESITRRQRAPSVAN--VGSHCDLSLKIPEISIQDMTAQVTSPSGKSHE 1361
            F V+V  E  +++    R   P +    VG   D  ++     +  +   +  PS    E
Sbjct: 539  FEVQVGPEAGMQKV---RAWGPGLHGGIVGRSADFVVESIGSEVGSLGFAIEGPSQAKIE 595

Query: 1362 AEIVEGENHTYC-IRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEG-GAHKVRAGG 1535
                  +N   C +++ P E G + V +    + +  SP+   + P   G     VRA G
Sbjct: 596  ---YNDQNDGSCDVKYWPKEPGEYAVHIMCDDEDIKDSPYMAFIHPATGGYNPDLVRAYG 652

Query: 1536 PGLERAEAGVP--AEFSIWTREAGAGGLAI-AVEGP-SKAEISFEDRKDGSCGVAYVVQE 1703
            PGLE++   V   AEF++  ++AG   L I A +G   + +I  ++R DG+   +Y   +
Sbjct: 653  PGLEKSGCIVNNLAEFTVDPKDAGKAPLKIFAQDGEGQRIDIQMKNRMDGTYACSYTPVK 712

Query: 1704 PGDYEVSVKFNEEHIPDSPFVVPVASPSGDAR-RLTVSSLQESGLKVNQPASFAVSLNGA 1880
               + ++V +   +IP SP+ V +   S   + ++    ++ SGLK N+P  F V    A
Sbjct: 713  AIKHTIAVVWGGVNIPHSPYRVNIGQGSHPQKVKVFGPGVERSGLKANEPTHFTVDCTEA 772

Query: 1881 -KGAI------DAKVHSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPG 2039
             +G +      DA+V S      +  +     D + V+++P   G Y I V F    IP 
Sbjct: 773  GEGDVSVGIKCDARVLSEDEEDVDFDIIHNANDTFTVKYVPPAAGRYTIKVLFASQEIPA 832

Query: 2040 SPFKIRVGEPGHGGDPGLVSAYGAGLE--GGVTGSPAEFIVNTSNAGAGALSVTIDGP-- 2207
            SPF+++V +P H  D   V A G GL   G   G P  F V T  AG   L+V  + P  
Sbjct: 833  SPFRVKV-DPSH--DASKVKAEGPGLSKAGVENGKPTHFTVYTKGAGKAPLNVQFNSPLP 889

Query: 2208 -SKVK-MD-CQECPEGYRVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHS 2378
               VK +D        + V YTP   G+  + + YGG   I  SPF   V          
Sbjct: 890  GDAVKDLDIIDNYDYSHTVKYTPTQQGNMQVLVTYGGD-PIPKSPFTVGVAA-------- 940

Query: 2379 LHETSSVFVDSLTKTXXXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKA- 2555
                                           SK+   GL  ++  VG+   FTVD   A 
Sbjct: 941  ---------------------------PLDLSKIKLNGLE-NRVEVGKDQEFTVDTRGAG 972

Query: 2556 GNNMLLVGVHGPRTPCEEILVKHVGSRLYSVS-YLLKDKGEYTLVVKWGDEHIPGSPYRV 2732
            G   L V +  P       LV  V  R  S + ++ +++G Y + V +    +PGSPY V
Sbjct: 973  GQGKLDVTILSPSRKVVPCLVTPVTGRENSTAKFIPREEGLYAVDVTYDGHPVPGSPYTV 1032



 Score =  139 bits (349), Expect = 2e-32
 Identities = 130/445 (29%), Positives = 195/445 (43%), Gaps = 15/445 (3%)
 Frame = +3

Query: 1449 KGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLERAEAGV--PAEFSIWTREAGAGGLAIA 1622
            K +  PG+P +  + P       K RA G G+E     V  PA+F++ T  AG G + + 
Sbjct: 239  KAKLKPGAPLKPKLNP------KKARAYGRGIEPTGNMVKQPAKFTVDTISAGQGDVMVF 292

Query: 1623 VEGPS----KAEISFEDRKDGSCGVAYVVQEPGDYEVSVKFNEEHIPDSPFVVPVASPSG 1790
            VE P     +A+++ +  K+ +  V Y+ +  G ++V+V F  +HI  SPF V V    G
Sbjct: 293  VEDPEGNKEEAQVTPDSDKNKTYSVEYLPKVTGLHKVTVLFAGQHISKSPFEVSVDKAQG 352

Query: 1791 DARRLTVS--SLQESGLKVNQPASFAVSLNGA-KGAIDAKVHSPSGA-LEECYVTEIDQD 1958
            DA ++T     L+  G   N+P  F +   GA  G I  +V  P G    E  V +    
Sbjct: 353  DASKVTAKGPGLEAVGNIANKPTYFDIYTAGAGVGDIGVEVEDPQGKNTVELLVEDKGNQ 412

Query: 1959 KYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPGLVSAYGAGLE--GGVT 2132
             Y   + P + G +++ + F G  IP SPF ++VGE     +P    A G GL+  G   
Sbjct: 413  VYRCVYKPMQPGPHVVKIFFAGDTIPKSPFVVQVGE---ACNPNACRASGRGLQPKGVRI 469

Query: 2133 GSPAEFIVNTSNAGAGALSVTIDGPSKVK--MDCQECPEG-YRVTYTPMAPGSYLISIKY 2303
                +F V+T  AG+G L VT+ GP  ++  +  ++  +G Y   Y P  PG Y I+I +
Sbjct: 470  RETTDFKVDTKAAGSGELGVTMKGPKGLEELVKQKDFLDGVYAFEYYPSTPGRYSIAITW 529

Query: 2304 GGPYHIGGSPFKARVTGHRLVSNHSLHETSSVFVDSLTKTXXXXXXXXXXXXXXXXSKVL 2483
            GG +HI  SPF+ +V                                          KV 
Sbjct: 530  GG-HHIPKSPFEVQV-----------------------------------GPEAGMQKVR 553

Query: 2484 AKGLGLSKAYVGQKGSFTVDCSKAGNNMLLVGVHGPRTPCEEILVKHVGSRLYSVSYLLK 2663
            A G GL    VG+   F V+   +    L   + GP     E   ++ GS    V Y  K
Sbjct: 554  AWGPGLHGGIVGRSADFVVESIGSEVGSLGFAIEGPSQAKIEYNDQNDGS--CDVKYWPK 611

Query: 2664 DKGEYTLVVKWGDEHIPGSPYRVLV 2738
            + GEY + +   DE I  SPY   +
Sbjct: 612  EPGEYAVHIMCDDEDIKDSPYMAFI 636


>ref|NP_001448.2| filamin-B isoform 2 [Homo sapiens].
          Length = 2602

 Score = 1313 bits (3399), Expect = 0.0
 Identities = 627/881 (71%), Positives = 744/881 (84%)
 Frame = +3

Query: 99   GQQTWAPERPLVGVNGLDVTSLRPFDLVIPFTIKKGEITGEVRMPSGKVAQPAITDNKDG 278
            G + W  E   V V+ ++    +PFDLVIPF ++KGEITGEV MPSGK A P I DNKDG
Sbjct: 1723 GFRPWVTEEAYVPVSDMNGLGFKPFDLVIPFAVRKGEITGEVHMPSGKTATPEIVDNKDG 1782

Query: 279  TVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFYVDYVNCGHVTAYGPGLSHGVVNKPAVF 458
            TVTVRYAP+E GLHEM I+Y   HIP SPLQFYV+Y N G V+AYGPGL +GV NK A F
Sbjct: 1783 TVTVRYAPTEVGLHEMHIKYMGSHIPESPLQFYVNYPNSGSVSAYGPGLVYGVANKTATF 1842

Query: 459  TVNTKDAGEGGLSLAIEGPSKAEISCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGS 638
            T+ T+DAGEGGL LAIEGPSKAEISC DN+DGTC+V+YLP LPGDYSILVKYN++HIPGS
Sbjct: 1843 TIVTEDAGEGGLDLAIEGPSKAEISCIDNKDGTCTVTYLPTLPGDYSILVKYNDKHIPGS 1902

Query: 639  PFTARVTGDDSMRMSHLKVGSAADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGH 818
            PFTA++T DDS R S +K+GSAAD  ++ISETDLS LTA++  PSGR+EPCLLKRL N H
Sbjct: 1903 PFTAKIT-DDSRRCSQVKLGSAADFLLDISETDLSSLTASIKAPSGRDEPCLLKRLPNNH 1961

Query: 819  VGISFVPKETGEHLVHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEGHTFEPA 998
            +GISF+P+E GEHLV +KKNG HVA+SP+ +++ QSEIGDA R +V GRGL EG TFE +
Sbjct: 1962 IGISFIPREVGEHLVSIKKNGNHVANSPVSIMVVQSEIGDARRAKVYGRGLSEGRTFEMS 2021

Query: 999  EFIIDTRDAGYGGLSLSIEGPSKVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVP 1178
            +FI+DTRDAGYGG+SL++EGPSKVDI TEDLEDGTC+V+Y PT PG YI++ KFAD+HVP
Sbjct: 2022 DFIVDTRDAGYGGISLAVEGPSKVDIQTEDLEDGTCKVSYFPTVPGVYIVSTKFADEHVP 2081

Query: 1179 GSPFSVKVTGEGRVKESITRRQRAPSVANVGSHCDLSLKIPEISIQDMTAQVTSPSGKSH 1358
            GSPF+VK++GEGRVKESITR  RAPSVA VGS CDL+LKIPEI+  DM+A VTSPSG+  
Sbjct: 2082 GSPFTVKISGEGRVKESITRTSRAPSVATVGSICDLNLKIPEINSSDMSAHVTSPSGRVT 2141

Query: 1359 EAEIVEGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGP 1538
            EAEIV    +++C+RFVP EMG+HTVSVKY+GQHV GSPFQFTVGPLGEGGAHKVRAGGP
Sbjct: 2142 EAEIVPMGKNSHCVRFVPQEMGVHTVSVKYRGQHVTGSPFQFTVGPLGEGGAHKVRAGGP 2201

Query: 1539 GLERAEAGVPAEFSIWTREAGAGGLAIAVEGPSKAEISFEDRKDGSCGVAYVVQEPGDYE 1718
            GLER EAGVPAEFSIWTREAGAGGL+IAVEGPSKAEI+F+D K+GSCGV+Y+ QEPG+YE
Sbjct: 2202 GLERGEAGVPAEFSIWTREAGAGGLSIAVEGPSKAEITFDDHKNGSCGVSYIAQEPGNYE 2261

Query: 1719 VSVKFNEEHIPDSPFVVPVASPSGDARRLTVSSLQESGLKVNQPASFAVSLNGAKGAIDA 1898
            VS+KFN+EHIP+SP++VPV +PS DARRLTV SLQESGLKVNQPASFA+ LNGAKG IDA
Sbjct: 2262 VSIKFNDEHIPESPYLVPVIAPSDDARRLTVMSLQESGLKVNQPASFAIRLNGAKGKIDA 2321

Query: 1899 KVHSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGHG 2078
            KVHSPSGA+EEC+V+E++ DKYAVRFIP ENGV+ IDVKFNG+H+ GSPFK+RVGEPG  
Sbjct: 2322 KVHSPSGAVEECHVSELEPDKYAVRFIPHENGVHTIDVKFNGSHVVGSPFKVRVGEPGQA 2381

Query: 2079 GDPGLVSAYGAGLEGGVTGSPAEFIVNTSNAGAGALSVTIDGPSKVKMDCQECPEGYRVT 2258
            G+P LVSAYG GLEGG TG  +EF +NT+ AG G LSVTI+GPSKVKMDCQE PEGY+V 
Sbjct: 2382 GNPALVSAYGTGLEGGTTGIQSEFFINTTRAGPGTLSVTIEGPSKVKMDCQETPEGYKVM 2441

Query: 2259 YTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSVFVDSLTKTXXXXX 2438
            YTPMAPG+YLIS+KYGGP HI GSPFKA+VTG RLVS  S +ETSS+ V+S+T++     
Sbjct: 2442 YTPMAPGNYLISVKYGGPNHIVGSPFKAKVTGQRLVSPGSANETSSILVESVTRSSTETC 2501

Query: 2439 XXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKAGNNMLLVGVHGPRTPCEEILV 2618
                       SKV +KG GLSKA+VGQK SF VDCSKAG+NMLL+GVHGP TPCEE+ +
Sbjct: 2502 YSAIPKASSDASKVTSKGAGLSKAFVGQKSSFLVDCSKAGSNMLLIGVHGPTTPCEEVSM 2561

Query: 2619 KHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLVP 2741
            KHVG++ Y+V+Y++K++G+Y L VKWG+EHIPGSP+ V VP
Sbjct: 2562 KHVGNQQYNVTYVVKERGDYVLAVKWGEEHIPGSPFHVTVP 2602



 Score =  334 bits (856), Expect = 3e-91
 Identities = 240/756 (31%), Positives = 368/756 (48%), Gaps = 39/756 (5%)
 Frame = +3

Query: 201  KGEITGEVRMPSGKVAQPAITD--NKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQF 374
            +G++   +  PS KV    +T    ++ + T ++ P E GL+ +D+ YD   +PGSP   
Sbjct: 974  QGKLDVTILSPSRKVVPCLVTPVTGRENS-TAKFIPREEGLYAVDVTYDGHPVPGSPYTV 1032

Query: 375  YVDYV-NCGHVTAYGPGLSHGVVNKPAVFTVNTKDAGEGGLSLAIEGPSKAEISCTDNQD 551
                  +   V A+GPGL  G+V KPA FT++TK AG GGL L +EGP +A+I C+DN D
Sbjct: 1033 EASLPPDPSKVKAHGPGLEGGLVGKPAEFTIDTKGAGTGGLGLTVEGPCEAKIECSDNGD 1092

Query: 552  GTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARV--------TGDDSMRMSHLKVGSAA 707
            GTCSVSYLP  PG+Y + + + E HIPGSPF A +               + H KVG A 
Sbjct: 1093 GTCSVSYLPTKPGEYFVNILFEEVHIPGSPFKADIEMPFDPSKVVASGPGLEHGKVGEAG 1152

Query: 708  DIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNGQH 887
             + ++ SE     L    V  SG +    ++  ++G   +++VP   G + + +K  G+ 
Sbjct: 1153 LLSVDCSEAGPGALGLEAVSDSGTKAEVSIQNNKDGTYAVTYVPLTAGMYTLTMKYGGEL 1212

Query: 888  VASSPIPVVISQSEIGDASRVRVSGRGLHEGHTFEPA--EFIIDTR---DAGYGGLSLSI 1052
            V   P  V +  +   D SR++V G G+     F  A  +F +D+R     G   +   I
Sbjct: 1213 VPHFPARVKVEPAV--DTSRIKVFGPGIEGKDVFREATTDFTVDSRPLTQVGGDHIKAHI 1270

Query: 1053 EGPS--KVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVT------- 1205
              PS    +    D  DGT +V Y P E G +++ + + D  +P SPF V VT       
Sbjct: 1271 ANPSGASTECFVTDNADGTYQVEYTPFEKGLHVVEVTYDDVPIPNSPFKVAVTEGCQPSR 1330

Query: 1206 ----GEGRVKESITRRQRAPSVANVGSHCDLSLKIPEISIQDMTAQVTSPSGKSHEAEIV 1373
                G G +KE+ T +    +V   G+            I  +   V  PS    +    
Sbjct: 1331 VQAQGPG-LKEAFTNKPNVFTVVTRGA-----------GIGGLGITVEGPS--ESKINCR 1376

Query: 1374 EGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGL-ER 1550
            + ++ +    ++P   G + V++ Y G H+PGSPF+  V  + +    KV+  GPGL   
Sbjct: 1377 DNKDGSCSAEYIPFAPGDYDVNITYGGAHIPGSPFRVPVKDVVD--PSKVKIAGPGLGSG 1434

Query: 1551 AEAGVPAEFSIWTREAGAGGLAIAVEGPS--KAEISFEDRKDGSCGVAYVVQEPGDYEVS 1724
              A V   F++ + +AG   L + V GP      ++  D  DG+  V Y   + G Y VS
Sbjct: 1435 VRARVLQSFTVDSSKAGLAPLEVRVLGPRGLVEPVNVVDNGDGTHTVTYTPSQEGPYMVS 1494

Query: 1725 VKFNEEHIPDSPFVVPVASPSGDARRLTVS--SLQESGLKVNQPASFAVSLNGA-KGAID 1895
            VK+ +E IP SPF V V  P+ DA ++T S   L   G+  + P  FA+    A +G + 
Sbjct: 1495 VKYADEEIPRSPFKVKVL-PTYDASKVTASGPGLSSYGVPASLPVDFAIDARDAGEGLLA 1553

Query: 1896 AKVHSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGH 2075
             ++    G  +   V +     YAV +IP + G Y+I V + G  IP SP++IR  +   
Sbjct: 1554 VQITDQEGKPKRAIVHDNKDGTYAVTYIPDKTGRYMIGVTYGGDDIPLSPYRIRATQT-- 1611

Query: 2076 GGDPGLVSAYGAGLEGGV-TGSPAEFIVNTSNAGAGALSVTIDGP--SKVKMDCQECPEG 2246
             GD     A G G+   V TG    F+V+   AG G ++ T+  P  ++ + D  E  +G
Sbjct: 1612 -GDASKCLATGPGIASTVKTGEEVGFVVDAKTAGKGKVTCTVLTPDGTEAEADVIENEDG 1670

Query: 2247 -YRVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVT 2351
             Y + YT   PG+Y+I +++GG   I  SPF    T
Sbjct: 1671 TYDIFYTAAKPGTYVIYVRFGG-VDIPNSPFTVMAT 1705



 Score =  295 bits (756), Expect = 1e-79
 Identities = 254/878 (28%), Positives = 399/878 (45%), Gaps = 56/878 (6%)
 Frame = +3

Query: 273  DGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFYVDYVNCGH------VTAYGPGLSHG 434
            DGT    Y P +A  H + + +  ++IP SP +     VN G       V  +GPG+   
Sbjct: 701  DGTYACSYTPVKAIKHTIAVVWGGVNIPHSPYR-----VNIGQGSHPQKVKVFGPGVERS 755

Query: 435  VV--NKPAVFTVNTKDAGEGGLSLAI--------EGPSKAEISCTDNQDGTCSVSYLPVL 584
             +  N+P  FTV+  +AGEG +S+ I        E     +     N + T +V Y+P  
Sbjct: 756  GLKANEPTHFTVDCTEAGEGDVSVGIKCDARVLSEDEEDVDFDIIHNANDTFTVKYVPPA 815

Query: 585  PGDYSILVKYNEQHIPGSPFTARV------------------TGDDSMRMSHLKVGS--A 704
             G Y+I V +  Q IP SPF  +V                   G ++ + +H  V +  A
Sbjct: 816  AGRYTIKVLFASQEIPASPFRVKVDPSHDASKVKAEGPGLSKAGVENGKPTHFTVYTKGA 875

Query: 705  ADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNGQ 884
               P+N+          + +P    ++  ++      H  + + P + G   V V   G 
Sbjct: 876  GKAPLNVQFN-------SPLPGDAVKDLDIIDNYDYSHT-VKYTPTQQGNMQVLVTYGGD 927

Query: 885  HVASSPIPVVISQSEIGDASRVRVSGRGLHEGHTFEPAEFIIDTRDAG-YGGLSLSIEGP 1061
             +  SP  V ++     D S+++++G   +     +  EF +DTR AG  G L ++I  P
Sbjct: 928  PIPKSPFTVGVAAPL--DLSKIKLNGLE-NRVEVGKDQEFTVDTRGAGGQGKLDVTILSP 984

Query: 1062 SKVDIN-----TEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTGEGRVKE 1226
            S+  +          E+ T +  + P E G Y +++ +    VPGSP++V+ +      +
Sbjct: 985  SRKVVPCLVTPVTGRENSTAK--FIPREEGLYAVDVTYDGHPVPGSPYTVEAS---LPPD 1039

Query: 1227 SITRRQRAPSVAN--VGSHCDLSLKIPEISIQDMTAQVTSPSGKSHEAEIVEGENH--TY 1394
                +   P +    VG   + ++         +   V  P     EA+I   +N   T 
Sbjct: 1040 PSKVKAHGPGLEGGLVGKPAEFTIDTKGAGTGGLGLTVEGPC----EAKIECSDNGDGTC 1095

Query: 1395 CIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLERAEAGVPAE 1574
             + ++P + G + V++ ++  H+PGSPF+  +    +    KV A GPGLE  + G    
Sbjct: 1096 SVSYLPTKPGEYFVNILFEEVHIPGSPFKADIEMPFDPS--KVVASGPGLEHGKVGEAGL 1153

Query: 1575 FSIWTREAGAG--GLAIAVEGPSKAEISFEDRKDGSCGVAYVVQEPGDYEVSVKFNEEHI 1748
             S+   EAG G  GL    +  +KAE+S ++ KDG+  V YV    G Y +++K+  E +
Sbjct: 1154 LSVDCSEAGPGALGLEAVSDSGTKAEVSIQNNKDGTYAVTYVPLTAGMYTLTMKYGGELV 1213

Query: 1749 PDSPFVVPVASPSGDARRLTVSSLQESGLKVNQPASFAVSLNGAK------GAIDAKVHS 1910
            P  P  V V  P+ D  R+ V      G  V + A+   +++           I A + +
Sbjct: 1214 PHFPARVKV-EPAVDTSRIKVFGPGIEGKDVFREATTDFTVDSRPLTQVGGDHIKAHIAN 1272

Query: 1911 PSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPG 2090
            PSGA  EC+VT+     Y V + P E G+++++V ++   IP SPFK+ V E   G  P 
Sbjct: 1273 PSGASTECFVTDNADGTYQVEYTPFEKGLHVVEVTYDDVPIPNSPFKVAVTE---GCQPS 1329

Query: 2091 LVSAYGAGLEGGVTGSPAEFIVNTSNAGAGALSVTIDGPSKVKMDCQECPEGY-RVTYTP 2267
             V A G GL+   T  P  F V T  AG G L +T++GPS+ K++C++  +G     Y P
Sbjct: 1330 RVQAQGPGLKEAFTNKPNVFTVVTRGAGIGGLGITVEGPSESKINCRDNKDGSCSAEYIP 1389

Query: 2268 MAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSVFVDSLTKTXXXXXXXX 2447
             APG Y ++I YGG  HI GSPF+  V          + + S V                
Sbjct: 1390 FAPGDYDVNITYGGA-HIPGSPFRVPVK--------DVVDPSKV---------------- 1424

Query: 2448 XXXXXXXXSKVLAKGLGLS-KAYVGQKGSFTVDCSKAGNNMLLVGVHGPRTPCEEILVKH 2624
                     K+   GLG   +A V Q  SFTVD SKAG   L V V GPR   E + V  
Sbjct: 1425 ---------KIAGPGLGSGVRARVLQ--SFTVDSSKAGLAPLEVRVLGPRGLVEPVNVVD 1473

Query: 2625 VGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLV 2738
             G   ++V+Y    +G Y + VK+ DE IP SP++V V
Sbjct: 1474 NGDGTHTVTYTPSQEGPYMVSVKYADEEIPRSPFKVKV 1511



 Score =  290 bits (741), Expect = 7e-78
 Identities = 239/892 (26%), Positives = 380/892 (42%), Gaps = 49/892 (5%)
 Frame = +3

Query: 201  KGEITGEVRMPSGKVAQPAIT--DNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQF 374
            +G++   V  P G   +  +T   +K+ T +V Y P   GLH++ + +   HI  SP + 
Sbjct: 286  QGDVMVFVEDPEGNKEEAQVTPDSDKNKTYSVEYLPKVTGLHKVTVLFAGQHISKSPFEV 345

Query: 375  YVDYV--NCGHVTAYGPGLS--HGVVNKPAVFTVNTKDAGEGGLSLAIEGP---SKAEIS 533
             VD    +   VTA GPGL     + NKP  F + T  AG G + + +E P   +  E+ 
Sbjct: 346  SVDKAQGDASKVTAKGPGLEAVGNIANKPTYFDIYTAGAGVGDIGVEVEDPQGKNTVELL 405

Query: 534  CTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARV----------TGDDSMRMS 683
              D  +      Y P+ PG + + + +    IP SPF  +V               ++  
Sbjct: 406  VEDKGNQVYRCVYKPMQPGPHVVKIFFAGDTIPKSPFVVQVGEACNPNACRASGRGLQPK 465

Query: 684  HLKVGSAADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLV 863
             +++    D  ++        L  T+  P G EE    K   +G     + P   G + +
Sbjct: 466  GVRIRETTDFKVDTKAAGSGELGVTMKGPKGLEELVKQKDFLDGVYAFEYYPSTPGRYSI 525

Query: 864  HVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEGHTFEPAEFIIDTRDAGYGGLS 1043
             +   G H+  SP  V +         +VR  G GLH G     A+F++++  +  G L 
Sbjct: 526  AITWGGHHIPKSPFEVQVGPE--AGMQKVRAWGPGLHGGIVGRSADFVVESIGSEVGSLG 583

Query: 1044 LSIEGPSKVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKV-TGEGRV 1220
             +IEGPS+  I   D  DG+C V Y P EPG Y ++I   D+ +  SP+   +    G  
Sbjct: 584  FAIEGPSQAKIEYNDQNDGSCDVKYWPKEPGEYAVHIMCDDEDIKDSPYMAFIHPATGGY 643

Query: 1221 KESITRRQ---RAPSVANVGSHCDLSLKIPEISIQDMTAQVTSPSGKSHEAEIVEGENHT 1391
               + R        S   V +  + ++   +     +        G+  + ++    + T
Sbjct: 644  NPDLVRAYGPGLEKSGCIVNNLAEFTVDPKDAGKAPLKIFAQDGEGQRIDIQMKNRMDGT 703

Query: 1392 YCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAH--KVRAGGPGLERA--EA 1559
            Y   + P +   HT++V + G ++P SP++  +G     G+H  KV+  GPG+ER+  +A
Sbjct: 704  YACSYTPVKAIKHTIAVVWGGVNIPHSPYRVNIGQ----GSHPQKVKVFGPGVERSGLKA 759

Query: 1560 GVPAEFSIWTREAGAGGLAIAVEGPSKAEISFEDRKD----------GSCGVAYVVQEPG 1709
              P  F++   EAG G +++ ++    A +  ED +D           +  V YV    G
Sbjct: 760  NEPTHFTVDCTEAGEGDVSVGIK--CDARVLSEDEEDVDFDIIHNANDTFTVKYVPPAAG 817

Query: 1710 DYEVSVKFNEEHIPDSPFVVPVASPSGDARRLTVS--SLQESGLKVNQPASFAVSLNGA- 1880
             Y + V F  + IP SPF V V  PS DA ++      L ++G++  +P  F V   GA 
Sbjct: 818  RYTIKVLFASQEIPASPFRVKV-DPSHDASKVKAEGPGLSKAGVENGKPTHFTVYTKGAG 876

Query: 1881 KGAIDAKVHS--PSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKI 2054
            K  ++ + +S  P  A+++  + +     + V++ P + G   + V + G  IP SPF +
Sbjct: 877  KAPLNVQFNSPLPGDAVKDLDIIDNYDYSHTVKYTPTQQGNMQVLVTYGGDPIPKSPFTV 936

Query: 2055 RVGEPGHGGDPGLVSAYGAGLEGGV-TGSPAEFIVNTSNAGA-GALSVTIDGPSKVKMDC 2228
             V  P       L      GLE  V  G   EF V+T  AG  G L VTI  PS+  + C
Sbjct: 937  GVAAP-----LDLSKIKLNGLENRVEVGKDQEFTVDTRGAGGQGKLDVTILSPSRKVVPC 991

Query: 2229 QECP----EGYRVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSS 2396
               P    E     + P   G Y + + Y G + + GSP+    +               
Sbjct: 992  LVTPVTGRENSTAKFIPREEGLYAVDVTYDG-HPVPGSPYTVEAS--------------- 1035

Query: 2397 VFVDSLTKTXXXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKAGNNMLLV 2576
                                     SKV A G GL    VG+   FT+D   AG   L +
Sbjct: 1036 --------------------LPPDPSKVKAHGPGLEGGLVGKPAEFTIDTKGAGTGGLGL 1075

Query: 2577 GVHGPRTPCE-EILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYR 2729
             V G   PCE +I     G    SVSYL    GEY + + + + HIPGSP++
Sbjct: 1076 TVEG---PCEAKIECSDNGDGTCSVSYLPTKPGEYFVNILFEEVHIPGSPFK 1124



 Score =  283 bits (723), Expect = 9e-76
 Identities = 247/888 (27%), Positives = 379/888 (42%), Gaps = 43/888 (4%)
 Frame = +3

Query: 204  GEITGEVRMPSGKVAQPAITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFYVD 383
            GE+   ++ P G        D  DG     Y PS  G + + I +   HIP SP +  V 
Sbjct: 485  GELGVTMKGPKGLEELVKQKDFLDGVYAFEYYPSTPGRYSIAITWGGHHIPKSPFEVQVG 544

Query: 384  -YVNCGHVTAYGPGLSHGVVNKPAVFTVNTKDAGEGGLSLAIEGPSKAEISCTDNQDGTC 560
                   V A+GPGL  G+V + A F V +  +  G L  AIEGPS+A+I   D  DG+C
Sbjct: 545  PEAGMQKVRAWGPGLHGGIVGRSADFVVESIGSEVGSLGFAIEGPSQAKIEYNDQNDGSC 604

Query: 561  SVSYLPVLPGDYSILVKYNEQHIPGSPFTARV---TG----------DDSMRMSHLKVGS 701
             V Y P  PG+Y++ +  +++ I  SP+ A +   TG             +  S   V +
Sbjct: 605  DVKYWPKEPGEYAVHIMCDDEDIKDSPYMAFIHPATGGYNPDLVRAYGPGLEKSGCIVNN 664

Query: 702  AADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNG 881
             A+  ++  +   + L        G+     +K   +G    S+ P +  +H + V   G
Sbjct: 665  LAEFTVDPKDAGKAPLKIFAQDGEGQRIDIQMKNRMDGTYACSYTPVKAIKHTIAVVWGG 724

Query: 882  QHVASSPIPVVISQSEIGDASRVRVSGRGLHEG--HTFEPAEFIIDTRDAGYGGLSLSIE 1055
             ++  SP  V I Q       +V+V G G+        EP  F +D  +AG G +S+ I+
Sbjct: 725  VNIPHSPYRVNIGQG--SHPQKVKVFGPGVERSGLKANEPTHFTVDCTEAGEGDVSVGIK 782

Query: 1056 GPSKVDINTEDLED----------GTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVT 1205
              ++V   +ED ED           T  V Y P   G Y I + FA Q +P SPF VKV 
Sbjct: 783  CDARV--LSEDEEDVDFDIIHNANDTFTVKYVPPAAGRYTIKVLFASQEIPASPFRVKVD 840

Query: 1206 ---GEGRVKESITRRQRAPSVANVGSHCDLSLKIPEISIQDMTAQVTSPSGKSHEAEIVE 1376
                  +VK       +A       +H  +  K    +  ++      P     + +I++
Sbjct: 841  PSHDASKVKAEGPGLSKAGVENGKPTHFTVYTKGAGKAPLNVQFNSPLPGDAVKDLDIID 900

Query: 1377 GENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLE-RA 1553
              ++++ +++ P + G   V V Y G  +P SP  FTVG        K++    GLE R 
Sbjct: 901  NYDYSHTVKYTPTQQGNMQVLVTYGGDPIPKSP--FTVGVAAPLDLSKIKLN--GLENRV 956

Query: 1554 EAGVPAEFSIWTREAGA-GGLAIAVEGPSKAEI-----SFEDRKDGSCGVAYVVQEPGDY 1715
            E G   EF++ TR AG  G L + +  PS+  +         R++ +    ++ +E G Y
Sbjct: 957  EVGKDQEFTVDTRGAGGQGKLDVTILSPSRKVVPCLVTPVTGRENST--AKFIPREEGLY 1014

Query: 1716 EVSVKFNEEHIPDSPFVVPVASPSGDARRLTVSSLQESGLKVNQPASFAVSLNGA-KGAI 1892
             V V ++   +P SP+ V  + P   ++        E GL V +PA F +   GA  G +
Sbjct: 1015 AVDVTYDGHPVPGSPYTVEASLPPDPSKVKAHGPGLEGGL-VGKPAEFTIDTKGAGTGGL 1073

Query: 1893 DAKVHSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPG 2072
               V  P  A  EC  ++      +V ++P + G Y +++ F   HIPGSPFK  +  P 
Sbjct: 1074 GLTVEGPCEAKIEC--SDNGDGTCSVSYLPTKPGEYFVNILFEEVHIPGSPFKADIEMP- 1130

Query: 2073 HGGDPGLVSAYGAGLEGGVTGSPAEFIVNTSNAGAGALSV--TIDGPSKVKMDCQECPEG 2246
               DP  V A G GLE G  G      V+ S AG GAL +    D  +K ++  Q   +G
Sbjct: 1131 --FDPSKVVASGPGLEHGKVGEAGLLSVDCSEAGPGALGLEAVSDSGTKAEVSIQNNKDG 1188

Query: 2247 -YRVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSVFVDSLTKT 2423
             Y VTY P+  G Y +++KYGG        F ARV     V      +TS +        
Sbjct: 1189 TYAVTYVPLTAGMYTLTMKYGGEL---VPHFPARVKVEPAV------DTSRI-------- 1231

Query: 2424 XXXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVD---CSKAGNNMLLVGVHGPR 2594
                             KV   G+     +      FTVD    ++ G + +   +  P 
Sbjct: 1232 -----------------KVFGPGIEGKDVFREATTDFTVDSRPLTQVGGDHIKAHIANPS 1274

Query: 2595 TPCEEILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLV 2738
                E  V       Y V Y   +KG + + V + D  IP SP++V V
Sbjct: 1275 GASTECFVTDNADGTYQVEYTPFEKGLHVVEVTYDDVPIPNSPFKVAV 1322



 Score =  229 bits (583), Expect = 2e-59
 Identities = 234/840 (27%), Positives = 368/840 (43%), Gaps = 47/840 (5%)
 Frame = +3

Query: 354  PGSPLQFYVDYVNCGHVTAYGPGL--SHGVVNKPAVFTVNTKDAGEGGLSLAIEGP---- 515
            PG+PL+     +N     AYG G+  +  +V +PA FTV+T  AG+G + + +E P    
Sbjct: 244  PGAPLK---PKLNPKKARAYGRGIEPTGNMVKQPAKFTVDTISAGQGDVMVFVEDPEGNK 300

Query: 516  SKAEISCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARV---TGDDSMRMSH 686
             +A+++   +++ T SV YLP + G + + V +  QHI  SPF   V    GD S   + 
Sbjct: 301  EEAQVTPDSDKNKTYSVEYLPKVTGLHKVTVLFAGQHISKSPFEVSVDKAQGDASKVTAK 360

Query: 687  ----LKVGSAADIP----INISETDLSLLTATVVPPSGREEPCLLKRLRNGHV-GISFVP 839
                  VG+ A+ P    I  +   +  +   V  P G+    LL   +   V    + P
Sbjct: 361  GPGLEAVGNIANKPTYFDIYTAGAGVGDIGVEVEDPQGKNTVELLVEDKGNQVYRCVYKP 420

Query: 840  KETGEHLVHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEG--HTFEPAEFIID 1013
             + G H+V +   G  +  SP   V+   E  + +  R SGRGL        E  +F +D
Sbjct: 421  MQPGPHVVKIFFAGDTIPKSPF--VVQVGEACNPNACRASGRGLQPKGVRIRETTDFKVD 478

Query: 1014 TRDAGYGGLSLSIEGPSKVD--INTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSP 1187
            T+ AG G L ++++GP  ++  +  +D  DG     Y P+ PG Y I I +   H+P SP
Sbjct: 479  TKAAGSGELGVTMKGPKGLEELVKQKDFLDGVYAFEYYPSTPGRYSIAITWGGHHIPKSP 538

Query: 1188 FSVKVTGEGRVKESITRRQRAPSVAN--VGSHCDLSLKIPEISIQDMTAQVTSPSGKSHE 1361
            F V+V  E  +++    R   P +    VG   D  ++     +  +   +  PS    E
Sbjct: 539  FEVQVGPEAGMQKV---RAWGPGLHGGIVGRSADFVVESIGSEVGSLGFAIEGPSQAKIE 595

Query: 1362 AEIVEGENHTYC-IRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEG-GAHKVRAGG 1535
                  +N   C +++ P E G + V +    + +  SP+   + P   G     VRA G
Sbjct: 596  ---YNDQNDGSCDVKYWPKEPGEYAVHIMCDDEDIKDSPYMAFIHPATGGYNPDLVRAYG 652

Query: 1536 PGLERAEAGVP--AEFSIWTREAGAGGLAI-AVEGP-SKAEISFEDRKDGSCGVAYVVQE 1703
            PGLE++   V   AEF++  ++AG   L I A +G   + +I  ++R DG+   +Y   +
Sbjct: 653  PGLEKSGCIVNNLAEFTVDPKDAGKAPLKIFAQDGEGQRIDIQMKNRMDGTYACSYTPVK 712

Query: 1704 PGDYEVSVKFNEEHIPDSPFVVPVASPSGDAR-RLTVSSLQESGLKVNQPASFAVSLNGA 1880
               + ++V +   +IP SP+ V +   S   + ++    ++ SGLK N+P  F V    A
Sbjct: 713  AIKHTIAVVWGGVNIPHSPYRVNIGQGSHPQKVKVFGPGVERSGLKANEPTHFTVDCTEA 772

Query: 1881 -KGAI------DAKVHSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPG 2039
             +G +      DA+V S      +  +     D + V+++P   G Y I V F    IP 
Sbjct: 773  GEGDVSVGIKCDARVLSEDEEDVDFDIIHNANDTFTVKYVPPAAGRYTIKVLFASQEIPA 832

Query: 2040 SPFKIRVGEPGHGGDPGLVSAYGAGLE--GGVTGSPAEFIVNTSNAGAGALSVTIDGP-- 2207
            SPF+++V +P H  D   V A G GL   G   G P  F V T  AG   L+V  + P  
Sbjct: 833  SPFRVKV-DPSH--DASKVKAEGPGLSKAGVENGKPTHFTVYTKGAGKAPLNVQFNSPLP 889

Query: 2208 -SKVK-MD-CQECPEGYRVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHS 2378
               VK +D        + V YTP   G+  + + YGG   I  SPF   V          
Sbjct: 890  GDAVKDLDIIDNYDYSHTVKYTPTQQGNMQVLVTYGGD-PIPKSPFTVGVAA-------- 940

Query: 2379 LHETSSVFVDSLTKTXXXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKA- 2555
                                           SK+   GL  ++  VG+   FTVD   A 
Sbjct: 941  ---------------------------PLDLSKIKLNGLE-NRVEVGKDQEFTVDTRGAG 972

Query: 2556 GNNMLLVGVHGPRTPCEEILVKHVGSRLYSVS-YLLKDKGEYTLVVKWGDEHIPGSPYRV 2732
            G   L V +  P       LV  V  R  S + ++ +++G Y + V +    +PGSPY V
Sbjct: 973  GQGKLDVTILSPSRKVVPCLVTPVTGRENSTAKFIPREEGLYAVDVTYDGHPVPGSPYTV 1032



 Score =  218 bits (555), Expect = 3e-56
 Identities = 229/898 (25%), Positives = 359/898 (39%), Gaps = 49/898 (5%)
 Frame = +3

Query: 192  TIKKGEITGEVRMPSGKVAQPAITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQ 371
            T  KG++T  V  P G  A+  + +N+DGT  + Y  ++ G + + +R+  + IP SP  
Sbjct: 1642 TAGKGKVTCTVLTPDGTEAEADVIENEDGTYDIFYTAAKPGTYVIYVRFGGVDIPNSPFT 1701

Query: 372  FY-----VDYVNCGHVTAYGPGLSHGVVNKPAVFTVNTKDAG-------------EGGLS 497
                   V  V    V A  PG    V  +  V   +    G             +G ++
Sbjct: 1702 VMATDGEVTAVEEAPVNACPPGFRPWVTEEAYVPVSDMNGLGFKPFDLVIPFAVRKGEIT 1761

Query: 498  LAIEGPS--KAEISCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARVTGDDS 671
              +  PS   A     DN+DGT +V Y P   G + + +KY   HIP SP    V   +S
Sbjct: 1762 GEVHMPSGKTATPEIVDNKDGTVTVRYAPTEVGLHEMHIKYMGSHIPESPLQFYVNYPNS 1821

Query: 672  MRMSHLKVG-------SAADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGIS 830
              +S    G         A   I   +     L   +  PS  E  C+    ++G   ++
Sbjct: 1822 GSVSAYGPGLVYGVANKTATFTIVTEDAGEGGLDLAIEGPSKAEISCIDN--KDGTCTVT 1879

Query: 831  FVPKETGEHLVHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEGHTFEPAEFII 1010
            ++P   G++ + VK N +H+  SP    I+  +    S+V++             A+F++
Sbjct: 1880 YLPTLPGDYSILVKYNDKHIPGSPFTAKIT-DDSRRCSQVKLG----------SAADFLL 1928

Query: 1011 DTRDAGYGGLSLSIEGPSKVD--INTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGS 1184
            D  +     L+ SI+ PS  D     + L +    +++ P E G ++++IK    HV  S
Sbjct: 1929 DISETDLSSLTASIKAPSGRDEPCLLKRLPNNHIGISFIPREVGEHLVSIKKNGNHVANS 1988

Query: 1185 PFSVKVTGEGRVKESITRRQRAP------SVANVGSHCDLSLKIPEISIQDMTAQVTSPS 1346
            P S+ V     V+  I   +RA       S        D  +   +     ++  V  PS
Sbjct: 1989 PVSIMV-----VQSEIGDARRAKVYGRGLSEGRTFEMSDFIVDTRDAGYGGISLAVEGPS 2043

Query: 1347 GKSHEAEIVEGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGA-HKV 1523
                + E  + E+ T  + + P   G++ VS K+  +HVPGSP  FTV   GEG     +
Sbjct: 2044 KVDIQTE--DLEDGTCKVSYFPTVPGVYIVSTKFADEHVPGSP--FTVKISGEGRVKESI 2099

Query: 1524 RAGGPGLERAEAGVPAEFSIWTREAGAGGLAIAVEGPS----KAEISFEDRKDGSCGVAY 1691
                     A  G   + ++   E  +  ++  V  PS    +AEI     K+  C V +
Sbjct: 2100 TRTSRAPSVATVGSICDLNLKIPEINSSDMSAHVTSPSGRVTEAEI-VPMGKNSHC-VRF 2157

Query: 1692 VVQEPGDYEVSVKFNEEHIPDSPFVVPVAS-PSGDARRLTVSSLQESGLKVNQPASFAV- 1865
            V QE G + VSVK+  +H+  SPF   V     G A ++          +   PA F++ 
Sbjct: 2158 VPQEMGVHTVSVKYRGQHVTGSPFQFTVGPLGEGGAHKVRAGGPGLERGEAGVPAEFSIW 2217

Query: 1866 SLNGAKGAIDAKVHSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSP 2045
            +     G +   V  PS A  E    +       V +I +E G Y + +KFN  HIP SP
Sbjct: 2218 TREAGAGGLSIAVEGPSKA--EITFDDHKNGSCGVSYIAQEPGNYEVSIKFNDEHIPESP 2275

Query: 2046 FKIRVGEPGHGGDPGLVSAYGAGLEGGVTGSPAEFIVNTSNAGAGALSVTIDGPSKVKMD 2225
            + + V  P    D   ++       G     PA F +   N   G +   +  PS    +
Sbjct: 2276 YLVPVIAP--SDDARRLTVMSLQESGLKVNQPASFAIRL-NGAKGKIDAKVHSPSGAVEE 2332

Query: 2226 CQEC---PEGYRVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSS 2396
            C      P+ Y V + P   G + I +K+ G  H+ GSPFK RV       N +L     
Sbjct: 2333 CHVSELEPDKYAVRFIPHENGVHTIDVKFNGS-HVVGSPFKVRVGEPGQAGNPAL----- 2386

Query: 2397 VFVDSLTKTXXXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKAGNNMLLV 2576
                                       V A G GL     G +  F ++ ++AG   L V
Sbjct: 2387 ---------------------------VSAYGTGLEGGTTGIQSEFFINTTRAGPGTLSV 2419

Query: 2577 GVHGP---RTPCEEILVKHVGSRLYSVSYLLKDKGEYTLVVKW-GDEHIPGSPYRVLV 2738
             + GP   +  C+E          Y V Y     G Y + VK+ G  HI GSP++  V
Sbjct: 2420 TIEGPSKVKMDCQET------PEGYKVMYTPMAPGNYLISVKYGGPNHIVGSPFKAKV 2471



 Score =  139 bits (349), Expect = 2e-32
 Identities = 130/445 (29%), Positives = 195/445 (43%), Gaps = 15/445 (3%)
 Frame = +3

Query: 1449 KGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLERAEAGV--PAEFSIWTREAGAGGLAIA 1622
            K +  PG+P +  + P       K RA G G+E     V  PA+F++ T  AG G + + 
Sbjct: 239  KAKLKPGAPLKPKLNP------KKARAYGRGIEPTGNMVKQPAKFTVDTISAGQGDVMVF 292

Query: 1623 VEGPS----KAEISFEDRKDGSCGVAYVVQEPGDYEVSVKFNEEHIPDSPFVVPVASPSG 1790
            VE P     +A+++ +  K+ +  V Y+ +  G ++V+V F  +HI  SPF V V    G
Sbjct: 293  VEDPEGNKEEAQVTPDSDKNKTYSVEYLPKVTGLHKVTVLFAGQHISKSPFEVSVDKAQG 352

Query: 1791 DARRLTVS--SLQESGLKVNQPASFAVSLNGA-KGAIDAKVHSPSGA-LEECYVTEIDQD 1958
            DA ++T     L+  G   N+P  F +   GA  G I  +V  P G    E  V +    
Sbjct: 353  DASKVTAKGPGLEAVGNIANKPTYFDIYTAGAGVGDIGVEVEDPQGKNTVELLVEDKGNQ 412

Query: 1959 KYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPGLVSAYGAGLE--GGVT 2132
             Y   + P + G +++ + F G  IP SPF ++VGE     +P    A G GL+  G   
Sbjct: 413  VYRCVYKPMQPGPHVVKIFFAGDTIPKSPFVVQVGE---ACNPNACRASGRGLQPKGVRI 469

Query: 2133 GSPAEFIVNTSNAGAGALSVTIDGPSKVK--MDCQECPEG-YRVTYTPMAPGSYLISIKY 2303
                +F V+T  AG+G L VT+ GP  ++  +  ++  +G Y   Y P  PG Y I+I +
Sbjct: 470  RETTDFKVDTKAAGSGELGVTMKGPKGLEELVKQKDFLDGVYAFEYYPSTPGRYSIAITW 529

Query: 2304 GGPYHIGGSPFKARVTGHRLVSNHSLHETSSVFVDSLTKTXXXXXXXXXXXXXXXXSKVL 2483
            GG +HI  SPF+ +V                                          KV 
Sbjct: 530  GG-HHIPKSPFEVQV-----------------------------------GPEAGMQKVR 553

Query: 2484 AKGLGLSKAYVGQKGSFTVDCSKAGNNMLLVGVHGPRTPCEEILVKHVGSRLYSVSYLLK 2663
            A G GL    VG+   F V+   +    L   + GP     E   ++ GS    V Y  K
Sbjct: 554  AWGPGLHGGIVGRSADFVVESIGSEVGSLGFAIEGPSQAKIEYNDQNDGS--CDVKYWPK 611

Query: 2664 DKGEYTLVVKWGDEHIPGSPYRVLV 2738
            + GEY + +   DE I  SPY   +
Sbjct: 612  EPGEYAVHIMCDDEDIKDSPYMAFI 636


>ref|NP_001157790.1| filamin-B isoform 3 [Homo sapiens].
          Length = 2591

 Score = 1309 bits (3388), Expect = 0.0
 Identities = 629/889 (70%), Positives = 747/889 (84%), Gaps = 5/889 (0%)
 Frame = +3

Query: 90   AQGGQQTWAPERPL-----VGVNGLDVTSLRPFDLVIPFTIKKGEITGEVRMPSGKVAQP 254
            A  G+ T   E P+     V V+ ++    +PFDLVIPF ++KGEITGEV MPSGK A P
Sbjct: 1704 ATDGEVTAVEEAPVTEEAYVPVSDMNGLGFKPFDLVIPFAVRKGEITGEVHMPSGKTATP 1763

Query: 255  AITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFYVDYVNCGHVTAYGPGLSHG 434
             I DNKDGTVTVRYAP+E GLHEM I+Y   HIP SPLQFYV+Y N G V+AYGPGL +G
Sbjct: 1764 EIVDNKDGTVTVRYAPTEVGLHEMHIKYMGSHIPESPLQFYVNYPNSGSVSAYGPGLVYG 1823

Query: 435  VVNKPAVFTVNTKDAGEGGLSLAIEGPSKAEISCTDNQDGTCSVSYLPVLPGDYSILVKY 614
            V NK A FT+ T+DAGEGGL LAIEGPSKAEISC DN+DGTC+V+YLP LPGDYSILVKY
Sbjct: 1824 VANKTATFTIVTEDAGEGGLDLAIEGPSKAEISCIDNKDGTCTVTYLPTLPGDYSILVKY 1883

Query: 615  NEQHIPGSPFTARVTGDDSMRMSHLKVGSAADIPINISETDLSLLTATVVPPSGREEPCL 794
            N++HIPGSPFTA++T DDS R S +K+GSAAD  ++ISETDLS LTA++  PSGR+EPCL
Sbjct: 1884 NDKHIPGSPFTAKIT-DDSRRCSQVKLGSAADFLLDISETDLSSLTASIKAPSGRDEPCL 1942

Query: 795  LKRLRNGHVGISFVPKETGEHLVHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLH 974
            LKRL N H+GISF+P+E GEHLV +KKNG HVA+SP+ +++ QSEIGDA R +V GRGL 
Sbjct: 1943 LKRLPNNHIGISFIPREVGEHLVSIKKNGNHVANSPVSIMVVQSEIGDARRAKVYGRGLS 2002

Query: 975  EGHTFEPAEFIIDTRDAGYGGLSLSIEGPSKVDINTEDLEDGTCRVTYCPTEPGNYIINI 1154
            EG TFE ++FI+DTRDAGYGG+SL++EGPSKVDI TEDLEDGTC+V+Y PT PG YI++ 
Sbjct: 2003 EGRTFEMSDFIVDTRDAGYGGISLAVEGPSKVDIQTEDLEDGTCKVSYFPTVPGVYIVST 2062

Query: 1155 KFADQHVPGSPFSVKVTGEGRVKESITRRQRAPSVANVGSHCDLSLKIPEISIQDMTAQV 1334
            KFAD+HVPGSPF+VK++GEGRVKESITR  RAPSVA VGS CDL+LKIPEI+  DM+A V
Sbjct: 2063 KFADEHVPGSPFTVKISGEGRVKESITRTSRAPSVATVGSICDLNLKIPEINSSDMSAHV 2122

Query: 1335 TSPSGKSHEAEIVEGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGA 1514
            TSPSG+  EAEIV    +++C+RFVP EMG+HTVSVKY+GQHV GSPFQFTVGPLGEGGA
Sbjct: 2123 TSPSGRVTEAEIVPMGKNSHCVRFVPQEMGVHTVSVKYRGQHVTGSPFQFTVGPLGEGGA 2182

Query: 1515 HKVRAGGPGLERAEAGVPAEFSIWTREAGAGGLAIAVEGPSKAEISFEDRKDGSCGVAYV 1694
            HKVRAGGPGLER EAGVPAEFSIWTREAGAGGL+IAVEGPSKAEI+F+D K+GSCGV+Y+
Sbjct: 2183 HKVRAGGPGLERGEAGVPAEFSIWTREAGAGGLSIAVEGPSKAEITFDDHKNGSCGVSYI 2242

Query: 1695 VQEPGDYEVSVKFNEEHIPDSPFVVPVASPSGDARRLTVSSLQESGLKVNQPASFAVSLN 1874
             QEPG+YEVS+KFN+EHIP+SP++VPV +PS DARRLTV SLQESGLKVNQPASFA+ LN
Sbjct: 2243 AQEPGNYEVSIKFNDEHIPESPYLVPVIAPSDDARRLTVMSLQESGLKVNQPASFAIRLN 2302

Query: 1875 GAKGAIDAKVHSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKI 2054
            GAKG IDAKVHSPSGA+EEC+V+E++ DKYAVRFIP ENGV+ IDVKFNG+H+ GSPFK+
Sbjct: 2303 GAKGKIDAKVHSPSGAVEECHVSELEPDKYAVRFIPHENGVHTIDVKFNGSHVVGSPFKV 2362

Query: 2055 RVGEPGHGGDPGLVSAYGAGLEGGVTGSPAEFIVNTSNAGAGALSVTIDGPSKVKMDCQE 2234
            RVGEPG  G+P LVSAYG GLEGG TG  +EF +NT+ AG G LSVTI+GPSKVKMDCQE
Sbjct: 2363 RVGEPGQAGNPALVSAYGTGLEGGTTGIQSEFFINTTRAGPGTLSVTIEGPSKVKMDCQE 2422

Query: 2235 CPEGYRVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSVFVDSL 2414
             PEGY+V YTPMAPG+YLIS+KYGGP HI GSPFKA+VTG RLVS  S +ETSS+ V+S+
Sbjct: 2423 TPEGYKVMYTPMAPGNYLISVKYGGPNHIVGSPFKAKVTGQRLVSPGSANETSSILVESV 2482

Query: 2415 TKTXXXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKAGNNMLLVGVHGPR 2594
            T++                SKV +KG GLSKA+VGQK SF VDCSKAG+NMLL+GVHGP 
Sbjct: 2483 TRSSTETCYSAIPKASSDASKVTSKGAGLSKAFVGQKSSFLVDCSKAGSNMLLIGVHGPT 2542

Query: 2595 TPCEEILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLVP 2741
            TPCEE+ +KHVG++ Y+V+Y++K++G+Y L VKWG+EHIPGSP+ V VP
Sbjct: 2543 TPCEEVSMKHVGNQQYNVTYVVKERGDYVLAVKWGEEHIPGSPFHVTVP 2591



 Score =  436 bits (1121), Expect = e-122
 Identities = 288/889 (32%), Positives = 424/889 (47%), Gaps = 21/889 (2%)
 Frame = +3

Query: 135  GVNGLDVTSLRPFDLVIPFT-IKKGEITGEVRMPSGKVAQPAITDNKDGTVTVRYAPSEA 311
            G++   V +  P D  I      +G +  ++    GK  +  + DNKDGT  V Y P + 
Sbjct: 1526 GLSSYGVPASLPVDFAIDARDAGEGLLAVQITDQEGKPKRAIVHDNKDGTYAVTYIPDKT 1585

Query: 312  GLHEMDIRYDNMHIPGSPLQFYVDYV-NCGHVTAYGPGLSHGVVNKPAV-FTVNTKDAGE 485
            G + + + Y    IP SP +       +     A GPG++  V     V F V+ K AG+
Sbjct: 1586 GRYMIGVTYGGDDIPLSPYRIRATQTGDASKCLATGPGIASTVKTGEEVGFVVDAKTAGK 1645

Query: 486  GGLSLAIEGP--SKAEISCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARVT 659
            G ++  +  P  ++AE    +N+DGT  + Y    PG Y I V++    IP SPFT   T
Sbjct: 1646 GKVTCTVLTPDGTEAEADVIENEDGTYDIFYTAAKPGTYVIYVRFGGVDIPNSPFTVMAT 1705

Query: 660  GDDSMRMSHLKVGSAADIPIN------ISETDLSL--------LTATVVPPSGREEPCLL 797
              +   +    V   A +P++          DL +        +T  V  PSG+     +
Sbjct: 1706 DGEVTAVEEAPVTEEAYVPVSDMNGLGFKPFDLVIPFAVRKGEITGEVHMPSGKTATPEI 1765

Query: 798  KRLRNGHVGISFVPKETGEHLVHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHE 977
               ++G V + + P E G H +H+K  G H+  SP+   ++    G  S     G GL  
Sbjct: 1766 VDNKDGTVTVRYAPTEVGLHEMHIKYMGSHIPESPLQFYVNYPNSGSVS---AYGPGLVY 1822

Query: 978  GHTFEPAEFIIDTRDAGYGGLSLSIEGPSKVDINTEDLEDGTCRVTYCPTEPGNYIINIK 1157
            G   + A F I T DAG GGL L+IEGPSK +I+  D +DGTC VTY PT PG+Y I +K
Sbjct: 1823 GVANKTATFTIVTEDAGEGGLDLAIEGPSKAEISCIDNKDGTCTVTYLPTLPGDYSILVK 1882

Query: 1158 FADQHVPGSPFSVKVTGEGRVKESITRRQRAPSVANVGSHCDLSLKIPEISIQDMTAQVT 1337
            + D+H+PGSPF+ K+T +           R  S   +GS  D  L I E  +  +TA + 
Sbjct: 1883 YNDKHIPGSPFTAKITDD----------SRRCSQVKLGSAADFLLDISETDLSSLTASIK 1932

Query: 1338 SPSGKSHEAEIVEGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAH 1517
            +PSG+     +    N+   I F+P E+G H VS+K  G HV  SP    V     G A 
Sbjct: 1933 APSGRDEPCLLKRLPNNHIGISFIPREVGEHLVSIKKNGNHVANSPVSIMVVQSEIGDAR 1992

Query: 1518 KVRAGGPGLERAEAGVPAEFSIWTREAGAGGLAIAVEGPSKAEISFEDRKDGSCGVAYVV 1697
            + +  G GL        ++F + TR+AG GG+++AVEGPSK +I  ED +DG+C V+Y  
Sbjct: 1993 RAKVYGRGLSEGRTFEMSDFIVDTRDAGYGGISLAVEGPSKVDIQTEDLEDGTCKVSYFP 2052

Query: 1698 QEPGDYEVSVKFNEEHIPDSPFVVPVASPSGDARRLTVSSLQESGLKVNQPASFAVSLNG 1877
              PG Y VS KF +EH+P SPF V ++        +T +S   S   V       + +  
Sbjct: 2053 TVPGVYIVSTKFADEHVPGSPFTVKISGEGRVKESITRTSRAPSVATVGSICDLNLKIPE 2112

Query: 1878 AKGA-IDAKVHSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKI 2054
               + + A V SPSG + E  +  + ++ + VRF+P+E GV+ + VK+ G H+ GSPF+ 
Sbjct: 2113 INSSDMSAHVTSPSGRVTEAEIVPMGKNSHCVRFVPQEMGVHTVSVKYRGQHVTGSPFQF 2172

Query: 2055 RVGEPGHGGDPGLVSAYGAGLEGGVTGSPAEFIVNTSNAGAGALSVTIDGPSKVKMDCQE 2234
             VG  G GG    V A G GLE G  G PAEF + T  AGAG LS+ ++GPSK ++   +
Sbjct: 2173 TVGPLGEGG-AHKVRAGGPGLERGEAGVPAEFSIWTREAGAGGLSIAVEGPSKAEITFDD 2231

Query: 2235 CPEG-YRVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSVFVDS 2411
               G   V+Y    PG+Y +SIK+    HI  SP+   V                     
Sbjct: 2232 HKNGSCGVSYIAQEPGNYEVSIKFNDE-HIPESPYLVPVIA------------------- 2271

Query: 2412 LTKTXXXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKAGNNMLLVGVHGP 2591
                                 ++    L  S   V Q  SF +  + A    +   VH P
Sbjct: 2272 ---------------PSDDARRLTVMSLQESGLKVNQPASFAIRLNGA-KGKIDAKVHSP 2315

Query: 2592 RTPCEEILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLV 2738
                EE  V  +    Y+V ++  + G +T+ VK+   H+ GSP++V V
Sbjct: 2316 SGAVEECHVSELEPDKYAVRFIPHENGVHTIDVKFNGSHVVGSPFKVRV 2364



 Score =  336 bits (861), Expect = 9e-92
 Identities = 264/887 (29%), Positives = 410/887 (46%), Gaps = 41/887 (4%)
 Frame = +3

Query: 201  KGEITGEVRMPSGKVAQPAITD--NKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQF 374
            +G++   +  PS KV    +T    ++ + T ++ P E GL+ +D+ YD   +PGSP   
Sbjct: 974  QGKLDVTILSPSRKVVPCLVTPVTGRENS-TAKFIPREEGLYAVDVTYDGHPVPGSPYTV 1032

Query: 375  YVDYV-NCGHVTAYGPGLSHGVVNKPAVFTVNTKDAGEGGLSLAIEGPSKAEISCTDNQD 551
                  +   V A+GPGL  G+V KPA FT++TK AG GGL L +EGP +A+I C+DN D
Sbjct: 1033 EASLPPDPSKVKAHGPGLEGGLVGKPAEFTIDTKGAGTGGLGLTVEGPCEAKIECSDNGD 1092

Query: 552  GTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARV--------TGDDSMRMSHLKVGSAA 707
            GTCSVSYLP  PG+Y + + + E HIPGSPF A +               + H KVG A 
Sbjct: 1093 GTCSVSYLPTKPGEYFVNILFEEVHIPGSPFKADIEMPFDPSKVVASGPGLEHGKVGEAG 1152

Query: 708  DIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNGQH 887
             + ++ SE     L    V  SG +    ++  ++G   +++VP   G + + +K  G+ 
Sbjct: 1153 LLSVDCSEAGPGALGLEAVSDSGTKAEVSIQNNKDGTYAVTYVPLTAGMYTLTMKYGGEL 1212

Query: 888  VASSPIPVVISQSEIGDASRVRVSGRGLHEGHTFEPA--EFIIDTR---DAGYGGLSLSI 1052
            V   P  V +  +   D SR++V G G+     F  A  +F +D+R     G   +   I
Sbjct: 1213 VPHFPARVKVEPAV--DTSRIKVFGPGIEGKDVFREATTDFTVDSRPLTQVGGDHIKAHI 1270

Query: 1053 EGPS--KVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVT------- 1205
              PS    +    D  DGT +V Y P E G +++ + + D  +P SPF V VT       
Sbjct: 1271 ANPSGASTECFVTDNADGTYQVEYTPFEKGLHVVEVTYDDVPIPNSPFKVAVTEGCQPSR 1330

Query: 1206 ----GEGRVKESITRRQRAPSVANVGSHCDLSLKIPEISIQDMTAQVTSPSGKSHEAEIV 1373
                G G +KE+ T +    +V   G+            I  +   V  PS    +    
Sbjct: 1331 VQAQGPG-LKEAFTNKPNVFTVVTRGA-----------GIGGLGITVEGPS--ESKINCR 1376

Query: 1374 EGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGL-ER 1550
            + ++ +    ++P   G + V++ Y G H+PGSPF+  V  + +    KV+  GPGL   
Sbjct: 1377 DNKDGSCSAEYIPFAPGDYDVNITYGGAHIPGSPFRVPVKDVVD--PSKVKIAGPGLGSG 1434

Query: 1551 AEAGVPAEFSIWTREAGAGGLAIAVEGPS--KAEISFEDRKDGSCGVAYVVQEPGDYEVS 1724
              A V   F++ + +AG   L + V GP      ++  D  DG+  V Y   + G Y VS
Sbjct: 1435 VRARVLQSFTVDSSKAGLAPLEVRVLGPRGLVEPVNVVDNGDGTHTVTYTPSQEGPYMVS 1494

Query: 1725 VKFNEEHIPDSPFVVPVASPSGDARRLTVS--SLQESGLKVNQPASFAVSLNGA-KGAID 1895
            VK+ +E IP SPF V V  P+ DA ++T S   L   G+  + P  FA+    A +G + 
Sbjct: 1495 VKYADEEIPRSPFKVKVL-PTYDASKVTASGPGLSSYGVPASLPVDFAIDARDAGEGLLA 1553

Query: 1896 AKVHSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGH 2075
             ++    G  +   V +     YAV +IP + G Y+I V + G  IP SP++IR  +   
Sbjct: 1554 VQITDQEGKPKRAIVHDNKDGTYAVTYIPDKTGRYMIGVTYGGDDIPLSPYRIRATQT-- 1611

Query: 2076 GGDPGLVSAYGAGLEGGV-TGSPAEFIVNTSNAGAGALSVTIDGP--SKVKMDCQECPEG 2246
             GD     A G G+   V TG    F+V+   AG G ++ T+  P  ++ + D  E  +G
Sbjct: 1612 -GDASKCLATGPGIASTVKTGEEVGFVVDAKTAGKGKVTCTVLTPDGTEAEADVIENEDG 1670

Query: 2247 -YRVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSVFVDSLTKT 2423
             Y + YT   PG+Y+I +++GG   I  SPF    T   + +      T   +V      
Sbjct: 1671 TYDIFYTAAKPGTYVIYVRFGG-VDIPNSPFTVMATDGEVTAVEEAPVTEEAYV------ 1723

Query: 2424 XXXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKAGNNMLLVGVHGP--RT 2597
                            + +  K   L   +  +KG  T +            VH P  +T
Sbjct: 1724 -----------PVSDMNGLGFKPFDLVIPFAVRKGEITGE------------VHMPSGKT 1760

Query: 2598 PCEEILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLV 2738
               EI+    G+   +V Y   + G + + +K+   HIP SP +  V
Sbjct: 1761 ATPEIVDNKDGT--VTVRYAPTEVGLHEMHIKYMGSHIPESPLQFYV 1805



 Score =  290 bits (741), Expect = 7e-78
 Identities = 239/892 (26%), Positives = 380/892 (42%), Gaps = 49/892 (5%)
 Frame = +3

Query: 201  KGEITGEVRMPSGKVAQPAIT--DNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQF 374
            +G++   V  P G   +  +T   +K+ T +V Y P   GLH++ + +   HI  SP + 
Sbjct: 286  QGDVMVFVEDPEGNKEEAQVTPDSDKNKTYSVEYLPKVTGLHKVTVLFAGQHISKSPFEV 345

Query: 375  YVDYV--NCGHVTAYGPGLS--HGVVNKPAVFTVNTKDAGEGGLSLAIEGP---SKAEIS 533
             VD    +   VTA GPGL     + NKP  F + T  AG G + + +E P   +  E+ 
Sbjct: 346  SVDKAQGDASKVTAKGPGLEAVGNIANKPTYFDIYTAGAGVGDIGVEVEDPQGKNTVELL 405

Query: 534  CTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARV----------TGDDSMRMS 683
              D  +      Y P+ PG + + + +    IP SPF  +V               ++  
Sbjct: 406  VEDKGNQVYRCVYKPMQPGPHVVKIFFAGDTIPKSPFVVQVGEACNPNACRASGRGLQPK 465

Query: 684  HLKVGSAADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLV 863
             +++    D  ++        L  T+  P G EE    K   +G     + P   G + +
Sbjct: 466  GVRIRETTDFKVDTKAAGSGELGVTMKGPKGLEELVKQKDFLDGVYAFEYYPSTPGRYSI 525

Query: 864  HVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEGHTFEPAEFIIDTRDAGYGGLS 1043
             +   G H+  SP  V +         +VR  G GLH G     A+F++++  +  G L 
Sbjct: 526  AITWGGHHIPKSPFEVQVGPE--AGMQKVRAWGPGLHGGIVGRSADFVVESIGSEVGSLG 583

Query: 1044 LSIEGPSKVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKV-TGEGRV 1220
             +IEGPS+  I   D  DG+C V Y P EPG Y ++I   D+ +  SP+   +    G  
Sbjct: 584  FAIEGPSQAKIEYNDQNDGSCDVKYWPKEPGEYAVHIMCDDEDIKDSPYMAFIHPATGGY 643

Query: 1221 KESITRRQ---RAPSVANVGSHCDLSLKIPEISIQDMTAQVTSPSGKSHEAEIVEGENHT 1391
               + R        S   V +  + ++   +     +        G+  + ++    + T
Sbjct: 644  NPDLVRAYGPGLEKSGCIVNNLAEFTVDPKDAGKAPLKIFAQDGEGQRIDIQMKNRMDGT 703

Query: 1392 YCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAH--KVRAGGPGLERA--EA 1559
            Y   + P +   HT++V + G ++P SP++  +G     G+H  KV+  GPG+ER+  +A
Sbjct: 704  YACSYTPVKAIKHTIAVVWGGVNIPHSPYRVNIGQ----GSHPQKVKVFGPGVERSGLKA 759

Query: 1560 GVPAEFSIWTREAGAGGLAIAVEGPSKAEISFEDRKD----------GSCGVAYVVQEPG 1709
              P  F++   EAG G +++ ++    A +  ED +D           +  V YV    G
Sbjct: 760  NEPTHFTVDCTEAGEGDVSVGIK--CDARVLSEDEEDVDFDIIHNANDTFTVKYVPPAAG 817

Query: 1710 DYEVSVKFNEEHIPDSPFVVPVASPSGDARRLTVS--SLQESGLKVNQPASFAVSLNGA- 1880
             Y + V F  + IP SPF V V  PS DA ++      L ++G++  +P  F V   GA 
Sbjct: 818  RYTIKVLFASQEIPASPFRVKV-DPSHDASKVKAEGPGLSKAGVENGKPTHFTVYTKGAG 876

Query: 1881 KGAIDAKVHS--PSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKI 2054
            K  ++ + +S  P  A+++  + +     + V++ P + G   + V + G  IP SPF +
Sbjct: 877  KAPLNVQFNSPLPGDAVKDLDIIDNYDYSHTVKYTPTQQGNMQVLVTYGGDPIPKSPFTV 936

Query: 2055 RVGEPGHGGDPGLVSAYGAGLEGGV-TGSPAEFIVNTSNAGA-GALSVTIDGPSKVKMDC 2228
             V  P       L      GLE  V  G   EF V+T  AG  G L VTI  PS+  + C
Sbjct: 937  GVAAP-----LDLSKIKLNGLENRVEVGKDQEFTVDTRGAGGQGKLDVTILSPSRKVVPC 991

Query: 2229 QECP----EGYRVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSS 2396
               P    E     + P   G Y + + Y G + + GSP+    +               
Sbjct: 992  LVTPVTGRENSTAKFIPREEGLYAVDVTYDG-HPVPGSPYTVEAS--------------- 1035

Query: 2397 VFVDSLTKTXXXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKAGNNMLLV 2576
                                     SKV A G GL    VG+   FT+D   AG   L +
Sbjct: 1036 --------------------LPPDPSKVKAHGPGLEGGLVGKPAEFTIDTKGAGTGGLGL 1075

Query: 2577 GVHGPRTPCE-EILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYR 2729
             V G   PCE +I     G    SVSYL    GEY + + + + HIPGSP++
Sbjct: 1076 TVEG---PCEAKIECSDNGDGTCSVSYLPTKPGEYFVNILFEEVHIPGSPFK 1124



 Score =  283 bits (723), Expect = 9e-76
 Identities = 247/888 (27%), Positives = 379/888 (42%), Gaps = 43/888 (4%)
 Frame = +3

Query: 204  GEITGEVRMPSGKVAQPAITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFYVD 383
            GE+   ++ P G        D  DG     Y PS  G + + I +   HIP SP +  V 
Sbjct: 485  GELGVTMKGPKGLEELVKQKDFLDGVYAFEYYPSTPGRYSIAITWGGHHIPKSPFEVQVG 544

Query: 384  -YVNCGHVTAYGPGLSHGVVNKPAVFTVNTKDAGEGGLSLAIEGPSKAEISCTDNQDGTC 560
                   V A+GPGL  G+V + A F V +  +  G L  AIEGPS+A+I   D  DG+C
Sbjct: 545  PEAGMQKVRAWGPGLHGGIVGRSADFVVESIGSEVGSLGFAIEGPSQAKIEYNDQNDGSC 604

Query: 561  SVSYLPVLPGDYSILVKYNEQHIPGSPFTARV---TG----------DDSMRMSHLKVGS 701
             V Y P  PG+Y++ +  +++ I  SP+ A +   TG             +  S   V +
Sbjct: 605  DVKYWPKEPGEYAVHIMCDDEDIKDSPYMAFIHPATGGYNPDLVRAYGPGLEKSGCIVNN 664

Query: 702  AADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNG 881
             A+  ++  +   + L        G+     +K   +G    S+ P +  +H + V   G
Sbjct: 665  LAEFTVDPKDAGKAPLKIFAQDGEGQRIDIQMKNRMDGTYACSYTPVKAIKHTIAVVWGG 724

Query: 882  QHVASSPIPVVISQSEIGDASRVRVSGRGLHEG--HTFEPAEFIIDTRDAGYGGLSLSIE 1055
             ++  SP  V I Q       +V+V G G+        EP  F +D  +AG G +S+ I+
Sbjct: 725  VNIPHSPYRVNIGQG--SHPQKVKVFGPGVERSGLKANEPTHFTVDCTEAGEGDVSVGIK 782

Query: 1056 GPSKVDINTEDLED----------GTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVT 1205
              ++V   +ED ED           T  V Y P   G Y I + FA Q +P SPF VKV 
Sbjct: 783  CDARV--LSEDEEDVDFDIIHNANDTFTVKYVPPAAGRYTIKVLFASQEIPASPFRVKVD 840

Query: 1206 ---GEGRVKESITRRQRAPSVANVGSHCDLSLKIPEISIQDMTAQVTSPSGKSHEAEIVE 1376
                  +VK       +A       +H  +  K    +  ++      P     + +I++
Sbjct: 841  PSHDASKVKAEGPGLSKAGVENGKPTHFTVYTKGAGKAPLNVQFNSPLPGDAVKDLDIID 900

Query: 1377 GENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLE-RA 1553
              ++++ +++ P + G   V V Y G  +P SP  FTVG        K++    GLE R 
Sbjct: 901  NYDYSHTVKYTPTQQGNMQVLVTYGGDPIPKSP--FTVGVAAPLDLSKIKLN--GLENRV 956

Query: 1554 EAGVPAEFSIWTREAGA-GGLAIAVEGPSKAEI-----SFEDRKDGSCGVAYVVQEPGDY 1715
            E G   EF++ TR AG  G L + +  PS+  +         R++ +    ++ +E G Y
Sbjct: 957  EVGKDQEFTVDTRGAGGQGKLDVTILSPSRKVVPCLVTPVTGRENST--AKFIPREEGLY 1014

Query: 1716 EVSVKFNEEHIPDSPFVVPVASPSGDARRLTVSSLQESGLKVNQPASFAVSLNGA-KGAI 1892
             V V ++   +P SP+ V  + P   ++        E GL V +PA F +   GA  G +
Sbjct: 1015 AVDVTYDGHPVPGSPYTVEASLPPDPSKVKAHGPGLEGGL-VGKPAEFTIDTKGAGTGGL 1073

Query: 1893 DAKVHSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPG 2072
               V  P  A  EC  ++      +V ++P + G Y +++ F   HIPGSPFK  +  P 
Sbjct: 1074 GLTVEGPCEAKIEC--SDNGDGTCSVSYLPTKPGEYFVNILFEEVHIPGSPFKADIEMP- 1130

Query: 2073 HGGDPGLVSAYGAGLEGGVTGSPAEFIVNTSNAGAGALSV--TIDGPSKVKMDCQECPEG 2246
               DP  V A G GLE G  G      V+ S AG GAL +    D  +K ++  Q   +G
Sbjct: 1131 --FDPSKVVASGPGLEHGKVGEAGLLSVDCSEAGPGALGLEAVSDSGTKAEVSIQNNKDG 1188

Query: 2247 -YRVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSVFVDSLTKT 2423
             Y VTY P+  G Y +++KYGG        F ARV     V      +TS +        
Sbjct: 1189 TYAVTYVPLTAGMYTLTMKYGGEL---VPHFPARVKVEPAV------DTSRI-------- 1231

Query: 2424 XXXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVD---CSKAGNNMLLVGVHGPR 2594
                             KV   G+     +      FTVD    ++ G + +   +  P 
Sbjct: 1232 -----------------KVFGPGIEGKDVFREATTDFTVDSRPLTQVGGDHIKAHIANPS 1274

Query: 2595 TPCEEILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLV 2738
                E  V       Y V Y   +KG + + V + D  IP SP++V V
Sbjct: 1275 GASTECFVTDNADGTYQVEYTPFEKGLHVVEVTYDDVPIPNSPFKVAV 1322



 Score =  229 bits (583), Expect = 2e-59
 Identities = 234/840 (27%), Positives = 368/840 (43%), Gaps = 47/840 (5%)
 Frame = +3

Query: 354  PGSPLQFYVDYVNCGHVTAYGPGL--SHGVVNKPAVFTVNTKDAGEGGLSLAIEGP---- 515
            PG+PL+     +N     AYG G+  +  +V +PA FTV+T  AG+G + + +E P    
Sbjct: 244  PGAPLK---PKLNPKKARAYGRGIEPTGNMVKQPAKFTVDTISAGQGDVMVFVEDPEGNK 300

Query: 516  SKAEISCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARV---TGDDSMRMSH 686
             +A+++   +++ T SV YLP + G + + V +  QHI  SPF   V    GD S   + 
Sbjct: 301  EEAQVTPDSDKNKTYSVEYLPKVTGLHKVTVLFAGQHISKSPFEVSVDKAQGDASKVTAK 360

Query: 687  ----LKVGSAADIP----INISETDLSLLTATVVPPSGREEPCLLKRLRNGHV-GISFVP 839
                  VG+ A+ P    I  +   +  +   V  P G+    LL   +   V    + P
Sbjct: 361  GPGLEAVGNIANKPTYFDIYTAGAGVGDIGVEVEDPQGKNTVELLVEDKGNQVYRCVYKP 420

Query: 840  KETGEHLVHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEG--HTFEPAEFIID 1013
             + G H+V +   G  +  SP   V+   E  + +  R SGRGL        E  +F +D
Sbjct: 421  MQPGPHVVKIFFAGDTIPKSPF--VVQVGEACNPNACRASGRGLQPKGVRIRETTDFKVD 478

Query: 1014 TRDAGYGGLSLSIEGPSKVD--INTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSP 1187
            T+ AG G L ++++GP  ++  +  +D  DG     Y P+ PG Y I I +   H+P SP
Sbjct: 479  TKAAGSGELGVTMKGPKGLEELVKQKDFLDGVYAFEYYPSTPGRYSIAITWGGHHIPKSP 538

Query: 1188 FSVKVTGEGRVKESITRRQRAPSVAN--VGSHCDLSLKIPEISIQDMTAQVTSPSGKSHE 1361
            F V+V  E  +++    R   P +    VG   D  ++     +  +   +  PS    E
Sbjct: 539  FEVQVGPEAGMQKV---RAWGPGLHGGIVGRSADFVVESIGSEVGSLGFAIEGPSQAKIE 595

Query: 1362 AEIVEGENHTYC-IRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEG-GAHKVRAGG 1535
                  +N   C +++ P E G + V +    + +  SP+   + P   G     VRA G
Sbjct: 596  ---YNDQNDGSCDVKYWPKEPGEYAVHIMCDDEDIKDSPYMAFIHPATGGYNPDLVRAYG 652

Query: 1536 PGLERAEAGVP--AEFSIWTREAGAGGLAI-AVEGP-SKAEISFEDRKDGSCGVAYVVQE 1703
            PGLE++   V   AEF++  ++AG   L I A +G   + +I  ++R DG+   +Y   +
Sbjct: 653  PGLEKSGCIVNNLAEFTVDPKDAGKAPLKIFAQDGEGQRIDIQMKNRMDGTYACSYTPVK 712

Query: 1704 PGDYEVSVKFNEEHIPDSPFVVPVASPSGDAR-RLTVSSLQESGLKVNQPASFAVSLNGA 1880
               + ++V +   +IP SP+ V +   S   + ++    ++ SGLK N+P  F V    A
Sbjct: 713  AIKHTIAVVWGGVNIPHSPYRVNIGQGSHPQKVKVFGPGVERSGLKANEPTHFTVDCTEA 772

Query: 1881 -KGAI------DAKVHSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPG 2039
             +G +      DA+V S      +  +     D + V+++P   G Y I V F    IP 
Sbjct: 773  GEGDVSVGIKCDARVLSEDEEDVDFDIIHNANDTFTVKYVPPAAGRYTIKVLFASQEIPA 832

Query: 2040 SPFKIRVGEPGHGGDPGLVSAYGAGLE--GGVTGSPAEFIVNTSNAGAGALSVTIDGP-- 2207
            SPF+++V +P H  D   V A G GL   G   G P  F V T  AG   L+V  + P  
Sbjct: 833  SPFRVKV-DPSH--DASKVKAEGPGLSKAGVENGKPTHFTVYTKGAGKAPLNVQFNSPLP 889

Query: 2208 -SKVK-MD-CQECPEGYRVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHS 2378
               VK +D        + V YTP   G+  + + YGG   I  SPF   V          
Sbjct: 890  GDAVKDLDIIDNYDYSHTVKYTPTQQGNMQVLVTYGGD-PIPKSPFTVGVAA-------- 940

Query: 2379 LHETSSVFVDSLTKTXXXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKA- 2555
                                           SK+   GL  ++  VG+   FTVD   A 
Sbjct: 941  ---------------------------PLDLSKIKLNGLE-NRVEVGKDQEFTVDTRGAG 972

Query: 2556 GNNMLLVGVHGPRTPCEEILVKHVGSRLYSVS-YLLKDKGEYTLVVKWGDEHIPGSPYRV 2732
            G   L V +  P       LV  V  R  S + ++ +++G Y + V +    +PGSPY V
Sbjct: 973  GQGKLDVTILSPSRKVVPCLVTPVTGRENSTAKFIPREEGLYAVDVTYDGHPVPGSPYTV 1032



 Score =  139 bits (349), Expect = 2e-32
 Identities = 130/445 (29%), Positives = 195/445 (43%), Gaps = 15/445 (3%)
 Frame = +3

Query: 1449 KGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLERAEAGV--PAEFSIWTREAGAGGLAIA 1622
            K +  PG+P +  + P       K RA G G+E     V  PA+F++ T  AG G + + 
Sbjct: 239  KAKLKPGAPLKPKLNP------KKARAYGRGIEPTGNMVKQPAKFTVDTISAGQGDVMVF 292

Query: 1623 VEGPS----KAEISFEDRKDGSCGVAYVVQEPGDYEVSVKFNEEHIPDSPFVVPVASPSG 1790
            VE P     +A+++ +  K+ +  V Y+ +  G ++V+V F  +HI  SPF V V    G
Sbjct: 293  VEDPEGNKEEAQVTPDSDKNKTYSVEYLPKVTGLHKVTVLFAGQHISKSPFEVSVDKAQG 352

Query: 1791 DARRLTVS--SLQESGLKVNQPASFAVSLNGA-KGAIDAKVHSPSGA-LEECYVTEIDQD 1958
            DA ++T     L+  G   N+P  F +   GA  G I  +V  P G    E  V +    
Sbjct: 353  DASKVTAKGPGLEAVGNIANKPTYFDIYTAGAGVGDIGVEVEDPQGKNTVELLVEDKGNQ 412

Query: 1959 KYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPGLVSAYGAGLE--GGVT 2132
             Y   + P + G +++ + F G  IP SPF ++VGE     +P    A G GL+  G   
Sbjct: 413  VYRCVYKPMQPGPHVVKIFFAGDTIPKSPFVVQVGE---ACNPNACRASGRGLQPKGVRI 469

Query: 2133 GSPAEFIVNTSNAGAGALSVTIDGPSKVK--MDCQECPEG-YRVTYTPMAPGSYLISIKY 2303
                +F V+T  AG+G L VT+ GP  ++  +  ++  +G Y   Y P  PG Y I+I +
Sbjct: 470  RETTDFKVDTKAAGSGELGVTMKGPKGLEELVKQKDFLDGVYAFEYYPSTPGRYSIAITW 529

Query: 2304 GGPYHIGGSPFKARVTGHRLVSNHSLHETSSVFVDSLTKTXXXXXXXXXXXXXXXXSKVL 2483
            GG +HI  SPF+ +V                                          KV 
Sbjct: 530  GG-HHIPKSPFEVQV-----------------------------------GPEAGMQKVR 553

Query: 2484 AKGLGLSKAYVGQKGSFTVDCSKAGNNMLLVGVHGPRTPCEEILVKHVGSRLYSVSYLLK 2663
            A G GL    VG+   F V+   +    L   + GP     E   ++ GS    V Y  K
Sbjct: 554  AWGPGLHGGIVGRSADFVVESIGSEVGSLGFAIEGPSQAKIEYNDQNDGS--CDVKYWPK 611

Query: 2664 DKGEYTLVVKWGDEHIPGSPYRVLV 2738
            + GEY + +   DE I  SPY   +
Sbjct: 612  EPGEYAVHIMCDDEDIKDSPYMAFI 636


>ref|NP_001157791.1| filamin-B isoform 4 [Homo sapiens].
          Length = 2578

 Score = 1308 bits (3386), Expect = 0.0
 Identities = 626/872 (71%), Positives = 741/872 (84%)
 Frame = +3

Query: 126  PLVGVNGLDVTSLRPFDLVIPFTIKKGEITGEVRMPSGKVAQPAITDNKDGTVTVRYAPS 305
            P+  +NGL     +PFDLVIPF ++KGEITGEV MPSGK A P I DNKDGTVTVRYAP+
Sbjct: 1711 PVSDMNGL---GFKPFDLVIPFAVRKGEITGEVHMPSGKTATPEIVDNKDGTVTVRYAPT 1767

Query: 306  EAGLHEMDIRYDNMHIPGSPLQFYVDYVNCGHVTAYGPGLSHGVVNKPAVFTVNTKDAGE 485
            E GLHEM I+Y   HIP SPLQFYV+Y N G V+AYGPGL +GV NK A FT+ T+DAGE
Sbjct: 1768 EVGLHEMHIKYMGSHIPESPLQFYVNYPNSGSVSAYGPGLVYGVANKTATFTIVTEDAGE 1827

Query: 486  GGLSLAIEGPSKAEISCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARVTGD 665
            GGL LAIEGPSKAEISC DN+DGTC+V+YLP LPGDYSILVKYN++HIPGSPFTA++T D
Sbjct: 1828 GGLDLAIEGPSKAEISCIDNKDGTCTVTYLPTLPGDYSILVKYNDKHIPGSPFTAKIT-D 1886

Query: 666  DSMRMSHLKVGSAADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKE 845
            DS R S +K+GSAAD  ++ISETDLS LTA++  PSGR+EPCLLKRL N H+GISF+P+E
Sbjct: 1887 DSRRCSQVKLGSAADFLLDISETDLSSLTASIKAPSGRDEPCLLKRLPNNHIGISFIPRE 1946

Query: 846  TGEHLVHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEGHTFEPAEFIIDTRDA 1025
             GEHLV +KKNG HVA+SP+ +++ QSEIGDA R +V GRGL EG TFE ++FI+DTRDA
Sbjct: 1947 VGEHLVSIKKNGNHVANSPVSIMVVQSEIGDARRAKVYGRGLSEGRTFEMSDFIVDTRDA 2006

Query: 1026 GYGGLSLSIEGPSKVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVT 1205
            GYGG+SL++EGPSKVDI TEDLEDGTC+V+Y PT PG YI++ KFAD+HVPGSPF+VK++
Sbjct: 2007 GYGGISLAVEGPSKVDIQTEDLEDGTCKVSYFPTVPGVYIVSTKFADEHVPGSPFTVKIS 2066

Query: 1206 GEGRVKESITRRQRAPSVANVGSHCDLSLKIPEISIQDMTAQVTSPSGKSHEAEIVEGEN 1385
            GEGRVKESITR  RAPSVA VGS CDL+LKIPEI+  DM+A VTSPSG+  EAEIV    
Sbjct: 2067 GEGRVKESITRTSRAPSVATVGSICDLNLKIPEINSSDMSAHVTSPSGRVTEAEIVPMGK 2126

Query: 1386 HTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLERAEAGV 1565
            +++C+RFVP EMG+HTVSVKY+GQHV GSPFQFTVGPLGEGGAHKVRAGGPGLER EAGV
Sbjct: 2127 NSHCVRFVPQEMGVHTVSVKYRGQHVTGSPFQFTVGPLGEGGAHKVRAGGPGLERGEAGV 2186

Query: 1566 PAEFSIWTREAGAGGLAIAVEGPSKAEISFEDRKDGSCGVAYVVQEPGDYEVSVKFNEEH 1745
            PAEFSIWTREAGAGGL+IAVEGPSKAEI+F+D K+GSCGV+Y+ QEPG+YEVS+KFN+EH
Sbjct: 2187 PAEFSIWTREAGAGGLSIAVEGPSKAEITFDDHKNGSCGVSYIAQEPGNYEVSIKFNDEH 2246

Query: 1746 IPDSPFVVPVASPSGDARRLTVSSLQESGLKVNQPASFAVSLNGAKGAIDAKVHSPSGAL 1925
            IP+SP++VPV +PS DARRLTV SLQESGLKVNQPASFA+ LNGAKG IDAKVHSPSGA+
Sbjct: 2247 IPESPYLVPVIAPSDDARRLTVMSLQESGLKVNQPASFAIRLNGAKGKIDAKVHSPSGAV 2306

Query: 1926 EECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPGLVSAY 2105
            EEC+V+E++ DKYAVRFIP ENGV+ IDVKFNG+H+ GSPFK+RVGEPG  G+P LVSAY
Sbjct: 2307 EECHVSELEPDKYAVRFIPHENGVHTIDVKFNGSHVVGSPFKVRVGEPGQAGNPALVSAY 2366

Query: 2106 GAGLEGGVTGSPAEFIVNTSNAGAGALSVTIDGPSKVKMDCQECPEGYRVTYTPMAPGSY 2285
            G GLEGG TG  +EF +NT+ AG G LSVTI+GPSKVKMDCQE PEGY+V YTPMAPG+Y
Sbjct: 2367 GTGLEGGTTGIQSEFFINTTRAGPGTLSVTIEGPSKVKMDCQETPEGYKVMYTPMAPGNY 2426

Query: 2286 LISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSVFVDSLTKTXXXXXXXXXXXXXX 2465
            LIS+KYGGP HI GSPFKA+VTG RLVS  S +ETSS+ V+S+T++              
Sbjct: 2427 LISVKYGGPNHIVGSPFKAKVTGQRLVSPGSANETSSILVESVTRSSTETCYSAIPKASS 2486

Query: 2466 XXSKVLAKGLGLSKAYVGQKGSFTVDCSKAGNNMLLVGVHGPRTPCEEILVKHVGSRLYS 2645
              SKV +KG GLSKA+VGQK SF VDCSKAG+NMLL+GVHGP TPCEE+ +KHVG++ Y+
Sbjct: 2487 DASKVTSKGAGLSKAFVGQKSSFLVDCSKAGSNMLLIGVHGPTTPCEEVSMKHVGNQQYN 2546

Query: 2646 VSYLLKDKGEYTLVVKWGDEHIPGSPYRVLVP 2741
            V+Y++K++G+Y L VKWG+EHIPGSP+ V VP
Sbjct: 2547 VTYVVKERGDYVLAVKWGEEHIPGSPFHVTVP 2578



 Score =  434 bits (1116), Expect = e-121
 Identities = 288/879 (32%), Positives = 426/879 (48%), Gaps = 11/879 (1%)
 Frame = +3

Query: 135  GVNGLDVTSLRPFDLVIPFT-IKKGEITGEVRMPSGKVAQPAITDNKDGTVTVRYAPSEA 311
            G++   V +  P D  I      +G +  ++    GK  +  + DNKDGT  V Y P + 
Sbjct: 1526 GLSSYGVPASLPVDFAIDARDAGEGLLAVQITDQEGKPKRAIVHDNKDGTYAVTYIPDKT 1585

Query: 312  GLHEMDIRYDNMHIPGSPLQFYVDYV-NCGHVTAYGPGLSHGVVNKPAV-FTVNTKDAGE 485
            G + + + Y    IP SP +       +     A GPG++  V     V F V+ K AG+
Sbjct: 1586 GRYMIGVTYGGDDIPLSPYRIRATQTGDASKCLATGPGIASTVKTGEEVGFVVDAKTAGK 1645

Query: 486  GGLSLAIEGP--SKAEISCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARVT 659
            G ++  +  P  ++AE    +N+DGT  + Y    PG Y I V++    IP SPFT  VT
Sbjct: 1646 GKVTCTVLTPDGTEAEADVIENEDGTYDIFYTAAKPGTYVIYVRFGGVDIPNSPFTVMVT 1705

Query: 660  GDDSMRMSHLK-VGSA---ADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGI 827
             +  + +S +  +G       IP  + + +   +T  V  PSG+     +   ++G V +
Sbjct: 1706 EEAYVPVSDMNGLGFKPFDLVIPFAVRKGE---ITGEVHMPSGKTATPEIVDNKDGTVTV 1762

Query: 828  SFVPKETGEHLVHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEGHTFEPAEFI 1007
             + P E G H +H+K  G H+  SP+   ++    G  S     G GL  G   + A F 
Sbjct: 1763 RYAPTEVGLHEMHIKYMGSHIPESPLQFYVNYPNSGSVS---AYGPGLVYGVANKTATFT 1819

Query: 1008 IDTRDAGYGGLSLSIEGPSKVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSP 1187
            I T DAG GGL L+IEGPSK +I+  D +DGTC VTY PT PG+Y I +K+ D+H+PGSP
Sbjct: 1820 IVTEDAGEGGLDLAIEGPSKAEISCIDNKDGTCTVTYLPTLPGDYSILVKYNDKHIPGSP 1879

Query: 1188 FSVKVTGEGRVKESITRRQRAPSVANVGSHCDLSLKIPEISIQDMTAQVTSPSGKSHEAE 1367
            F+ K+T +           R  S   +GS  D  L I E  +  +TA + +PSG+     
Sbjct: 1880 FTAKITDD----------SRRCSQVKLGSAADFLLDISETDLSSLTASIKAPSGRDEPCL 1929

Query: 1368 IVEGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLE 1547
            +    N+   I F+P E+G H VS+K  G HV  SP    V     G A + +  G GL 
Sbjct: 1930 LKRLPNNHIGISFIPREVGEHLVSIKKNGNHVANSPVSIMVVQSEIGDARRAKVYGRGLS 1989

Query: 1548 RAEAGVPAEFSIWTREAGAGGLAIAVEGPSKAEISFEDRKDGSCGVAYVVQEPGDYEVSV 1727
                   ++F + TR+AG GG+++AVEGPSK +I  ED +DG+C V+Y    PG Y VS 
Sbjct: 1990 EGRTFEMSDFIVDTRDAGYGGISLAVEGPSKVDIQTEDLEDGTCKVSYFPTVPGVYIVST 2049

Query: 1728 KFNEEHIPDSPFVVPVASPSGDARRLTVSSLQESGLKVNQPASFAVSLNGAKGA-IDAKV 1904
            KF +EH+P SPF V ++        +T +S   S   V       + +     + + A V
Sbjct: 2050 KFADEHVPGSPFTVKISGEGRVKESITRTSRAPSVATVGSICDLNLKIPEINSSDMSAHV 2109

Query: 1905 HSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGD 2084
             SPSG + E  +  + ++ + VRF+P+E GV+ + VK+ G H+ GSPF+  VG  G GG 
Sbjct: 2110 TSPSGRVTEAEIVPMGKNSHCVRFVPQEMGVHTVSVKYRGQHVTGSPFQFTVGPLGEGG- 2168

Query: 2085 PGLVSAYGAGLEGGVTGSPAEFIVNTSNAGAGALSVTIDGPSKVKMDCQECPEG-YRVTY 2261
               V A G GLE G  G PAEF + T  AGAG LS+ ++GPSK ++   +   G   V+Y
Sbjct: 2169 AHKVRAGGPGLERGEAGVPAEFSIWTREAGAGGLSIAVEGPSKAEITFDDHKNGSCGVSY 2228

Query: 2262 TPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSVFVDSLTKTXXXXXX 2441
                PG+Y +SIK+    HI  SP+   V                               
Sbjct: 2229 IAQEPGNYEVSIKFNDE-HIPESPYLVPVIA----------------------------- 2258

Query: 2442 XXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKAGNNMLLVGVHGPRTPCEEILVK 2621
                       ++    L  S   V Q  SF +  + A    +   VH P    EE  V 
Sbjct: 2259 -----PSDDARRLTVMSLQESGLKVNQPASFAIRLNGA-KGKIDAKVHSPSGAVEECHVS 2312

Query: 2622 HVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLV 2738
             +    Y+V ++  + G +T+ VK+   H+ GSP++V V
Sbjct: 2313 ELEPDKYAVRFIPHENGVHTIDVKFNGSHVVGSPFKVRV 2351



 Score =  335 bits (860), Expect = 1e-91
 Identities = 241/756 (31%), Positives = 369/756 (48%), Gaps = 39/756 (5%)
 Frame = +3

Query: 201  KGEITGEVRMPSGKVAQPAITD--NKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQF 374
            +G++   +  PS KV    +T    ++ + T ++ P E GL+ +D+ YD   +PGSP   
Sbjct: 974  QGKLDVTILSPSRKVVPCLVTPVTGRENS-TAKFIPREEGLYAVDVTYDGHPVPGSPYTV 1032

Query: 375  YVDYV-NCGHVTAYGPGLSHGVVNKPAVFTVNTKDAGEGGLSLAIEGPSKAEISCTDNQD 551
                  +   V A+GPGL  G+V KPA FT++TK AG GGL L +EGP +A+I C+DN D
Sbjct: 1033 EASLPPDPSKVKAHGPGLEGGLVGKPAEFTIDTKGAGTGGLGLTVEGPCEAKIECSDNGD 1092

Query: 552  GTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARV--------TGDDSMRMSHLKVGSAA 707
            GTCSVSYLP  PG+Y + + + E HIPGSPF A +               + H KVG A 
Sbjct: 1093 GTCSVSYLPTKPGEYFVNILFEEVHIPGSPFKADIEMPFDPSKVVASGPGLEHGKVGEAG 1152

Query: 708  DIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNGQH 887
             + ++ SE     L    V  SG +    ++  ++G   +++VP   G + + +K  G+ 
Sbjct: 1153 LLSVDCSEAGPGALGLEAVSDSGTKAEVSIQNNKDGTYAVTYVPLTAGMYTLTMKYGGEL 1212

Query: 888  VASSPIPVVISQSEIGDASRVRVSGRGLHEGHTFEPA--EFIIDTR---DAGYGGLSLSI 1052
            V   P  V +  +   D SR++V G G+     F  A  +F +D+R     G   +   I
Sbjct: 1213 VPHFPARVKVEPAV--DTSRIKVFGPGIEGKDVFREATTDFTVDSRPLTQVGGDHIKAHI 1270

Query: 1053 EGPS--KVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVT------- 1205
              PS    +    D  DGT +V Y P E G +++ + + D  +P SPF V VT       
Sbjct: 1271 ANPSGASTECFVTDNADGTYQVEYTPFEKGLHVVEVTYDDVPIPNSPFKVAVTEGCQPSR 1330

Query: 1206 ----GEGRVKESITRRQRAPSVANVGSHCDLSLKIPEISIQDMTAQVTSPSGKSHEAEIV 1373
                G G +KE+ T +    +V   G+            I  +   V  PS    +    
Sbjct: 1331 VQAQGPG-LKEAFTNKPNVFTVVTRGA-----------GIGGLGITVEGPS--ESKINCR 1376

Query: 1374 EGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGL-ER 1550
            + ++ +    ++P   G + V++ Y G H+PGSPF+  V  + +    KV+  GPGL   
Sbjct: 1377 DNKDGSCSAEYIPFAPGDYDVNITYGGAHIPGSPFRVPVKDVVD--PSKVKIAGPGLGSG 1434

Query: 1551 AEAGVPAEFSIWTREAGAGGLAIAVEGPS--KAEISFEDRKDGSCGVAYVVQEPGDYEVS 1724
              A V   F++ + +AG   L + V GP      ++  D  DG+  V Y   + G Y VS
Sbjct: 1435 VRARVLQSFTVDSSKAGLAPLEVRVLGPRGLVEPVNVVDNGDGTHTVTYTPSQEGPYMVS 1494

Query: 1725 VKFNEEHIPDSPFVVPVASPSGDARRLTVS--SLQESGLKVNQPASFAVSLNGA-KGAID 1895
            VK+ +E IP SPF V V  P+ DA ++T S   L   G+  + P  FA+    A +G + 
Sbjct: 1495 VKYADEEIPRSPFKVKVL-PTYDASKVTASGPGLSSYGVPASLPVDFAIDARDAGEGLLA 1553

Query: 1896 AKVHSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGH 2075
             ++    G  +   V +     YAV +IP + G Y+I V + G  IP SP++IR  +   
Sbjct: 1554 VQITDQEGKPKRAIVHDNKDGTYAVTYIPDKTGRYMIGVTYGGDDIPLSPYRIRATQT-- 1611

Query: 2076 GGDPGLVSAYGAGLEGGV-TGSPAEFIVNTSNAGAGALSVTIDGP--SKVKMDCQECPEG 2246
             GD     A G G+   V TG    F+V+   AG G ++ T+  P  ++ + D  E  +G
Sbjct: 1612 -GDASKCLATGPGIASTVKTGEEVGFVVDAKTAGKGKVTCTVLTPDGTEAEADVIENEDG 1670

Query: 2247 -YRVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVT 2351
             Y + YT   PG+Y+I +++GG   I  SPF   VT
Sbjct: 1671 TYDIFYTAAKPGTYVIYVRFGG-VDIPNSPFTVMVT 1705



 Score =  295 bits (756), Expect = 1e-79
 Identities = 254/878 (28%), Positives = 399/878 (45%), Gaps = 56/878 (6%)
 Frame = +3

Query: 273  DGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFYVDYVNCGH------VTAYGPGLSHG 434
            DGT    Y P +A  H + + +  ++IP SP +     VN G       V  +GPG+   
Sbjct: 701  DGTYACSYTPVKAIKHTIAVVWGGVNIPHSPYR-----VNIGQGSHPQKVKVFGPGVERS 755

Query: 435  VV--NKPAVFTVNTKDAGEGGLSLAI--------EGPSKAEISCTDNQDGTCSVSYLPVL 584
             +  N+P  FTV+  +AGEG +S+ I        E     +     N + T +V Y+P  
Sbjct: 756  GLKANEPTHFTVDCTEAGEGDVSVGIKCDARVLSEDEEDVDFDIIHNANDTFTVKYVPPA 815

Query: 585  PGDYSILVKYNEQHIPGSPFTARV------------------TGDDSMRMSHLKVGS--A 704
             G Y+I V +  Q IP SPF  +V                   G ++ + +H  V +  A
Sbjct: 816  AGRYTIKVLFASQEIPASPFRVKVDPSHDASKVKAEGPGLSKAGVENGKPTHFTVYTKGA 875

Query: 705  ADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNGQ 884
               P+N+          + +P    ++  ++      H  + + P + G   V V   G 
Sbjct: 876  GKAPLNVQFN-------SPLPGDAVKDLDIIDNYDYSHT-VKYTPTQQGNMQVLVTYGGD 927

Query: 885  HVASSPIPVVISQSEIGDASRVRVSGRGLHEGHTFEPAEFIIDTRDAG-YGGLSLSIEGP 1061
             +  SP  V ++     D S+++++G   +     +  EF +DTR AG  G L ++I  P
Sbjct: 928  PIPKSPFTVGVAAPL--DLSKIKLNGLE-NRVEVGKDQEFTVDTRGAGGQGKLDVTILSP 984

Query: 1062 SKVDIN-----TEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTGEGRVKE 1226
            S+  +          E+ T +  + P E G Y +++ +    VPGSP++V+ +      +
Sbjct: 985  SRKVVPCLVTPVTGRENSTAK--FIPREEGLYAVDVTYDGHPVPGSPYTVEAS---LPPD 1039

Query: 1227 SITRRQRAPSVAN--VGSHCDLSLKIPEISIQDMTAQVTSPSGKSHEAEIVEGENH--TY 1394
                +   P +    VG   + ++         +   V  P     EA+I   +N   T 
Sbjct: 1040 PSKVKAHGPGLEGGLVGKPAEFTIDTKGAGTGGLGLTVEGPC----EAKIECSDNGDGTC 1095

Query: 1395 CIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLERAEAGVPAE 1574
             + ++P + G + V++ ++  H+PGSPF+  +    +    KV A GPGLE  + G    
Sbjct: 1096 SVSYLPTKPGEYFVNILFEEVHIPGSPFKADIEMPFDPS--KVVASGPGLEHGKVGEAGL 1153

Query: 1575 FSIWTREAGAG--GLAIAVEGPSKAEISFEDRKDGSCGVAYVVQEPGDYEVSVKFNEEHI 1748
             S+   EAG G  GL    +  +KAE+S ++ KDG+  V YV    G Y +++K+  E +
Sbjct: 1154 LSVDCSEAGPGALGLEAVSDSGTKAEVSIQNNKDGTYAVTYVPLTAGMYTLTMKYGGELV 1213

Query: 1749 PDSPFVVPVASPSGDARRLTVSSLQESGLKVNQPASFAVSLNGAK------GAIDAKVHS 1910
            P  P  V V  P+ D  R+ V      G  V + A+   +++           I A + +
Sbjct: 1214 PHFPARVKV-EPAVDTSRIKVFGPGIEGKDVFREATTDFTVDSRPLTQVGGDHIKAHIAN 1272

Query: 1911 PSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPG 2090
            PSGA  EC+VT+     Y V + P E G+++++V ++   IP SPFK+ V E   G  P 
Sbjct: 1273 PSGASTECFVTDNADGTYQVEYTPFEKGLHVVEVTYDDVPIPNSPFKVAVTE---GCQPS 1329

Query: 2091 LVSAYGAGLEGGVTGSPAEFIVNTSNAGAGALSVTIDGPSKVKMDCQECPEGY-RVTYTP 2267
             V A G GL+   T  P  F V T  AG G L +T++GPS+ K++C++  +G     Y P
Sbjct: 1330 RVQAQGPGLKEAFTNKPNVFTVVTRGAGIGGLGITVEGPSESKINCRDNKDGSCSAEYIP 1389

Query: 2268 MAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSVFVDSLTKTXXXXXXXX 2447
             APG Y ++I YGG  HI GSPF+  V          + + S V                
Sbjct: 1390 FAPGDYDVNITYGGA-HIPGSPFRVPVK--------DVVDPSKV---------------- 1424

Query: 2448 XXXXXXXXSKVLAKGLGLS-KAYVGQKGSFTVDCSKAGNNMLLVGVHGPRTPCEEILVKH 2624
                     K+   GLG   +A V Q  SFTVD SKAG   L V V GPR   E + V  
Sbjct: 1425 ---------KIAGPGLGSGVRARVLQ--SFTVDSSKAGLAPLEVRVLGPRGLVEPVNVVD 1473

Query: 2625 VGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLV 2738
             G   ++V+Y    +G Y + VK+ DE IP SP++V V
Sbjct: 1474 NGDGTHTVTYTPSQEGPYMVSVKYADEEIPRSPFKVKV 1511



 Score =  290 bits (741), Expect = 7e-78
 Identities = 239/892 (26%), Positives = 380/892 (42%), Gaps = 49/892 (5%)
 Frame = +3

Query: 201  KGEITGEVRMPSGKVAQPAIT--DNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQF 374
            +G++   V  P G   +  +T   +K+ T +V Y P   GLH++ + +   HI  SP + 
Sbjct: 286  QGDVMVFVEDPEGNKEEAQVTPDSDKNKTYSVEYLPKVTGLHKVTVLFAGQHISKSPFEV 345

Query: 375  YVDYV--NCGHVTAYGPGLS--HGVVNKPAVFTVNTKDAGEGGLSLAIEGP---SKAEIS 533
             VD    +   VTA GPGL     + NKP  F + T  AG G + + +E P   +  E+ 
Sbjct: 346  SVDKAQGDASKVTAKGPGLEAVGNIANKPTYFDIYTAGAGVGDIGVEVEDPQGKNTVELL 405

Query: 534  CTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARV----------TGDDSMRMS 683
              D  +      Y P+ PG + + + +    IP SPF  +V               ++  
Sbjct: 406  VEDKGNQVYRCVYKPMQPGPHVVKIFFAGDTIPKSPFVVQVGEACNPNACRASGRGLQPK 465

Query: 684  HLKVGSAADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLV 863
             +++    D  ++        L  T+  P G EE    K   +G     + P   G + +
Sbjct: 466  GVRIRETTDFKVDTKAAGSGELGVTMKGPKGLEELVKQKDFLDGVYAFEYYPSTPGRYSI 525

Query: 864  HVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEGHTFEPAEFIIDTRDAGYGGLS 1043
             +   G H+  SP  V +         +VR  G GLH G     A+F++++  +  G L 
Sbjct: 526  AITWGGHHIPKSPFEVQVGPE--AGMQKVRAWGPGLHGGIVGRSADFVVESIGSEVGSLG 583

Query: 1044 LSIEGPSKVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKV-TGEGRV 1220
             +IEGPS+  I   D  DG+C V Y P EPG Y ++I   D+ +  SP+   +    G  
Sbjct: 584  FAIEGPSQAKIEYNDQNDGSCDVKYWPKEPGEYAVHIMCDDEDIKDSPYMAFIHPATGGY 643

Query: 1221 KESITRRQ---RAPSVANVGSHCDLSLKIPEISIQDMTAQVTSPSGKSHEAEIVEGENHT 1391
               + R        S   V +  + ++   +     +        G+  + ++    + T
Sbjct: 644  NPDLVRAYGPGLEKSGCIVNNLAEFTVDPKDAGKAPLKIFAQDGEGQRIDIQMKNRMDGT 703

Query: 1392 YCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAH--KVRAGGPGLERA--EA 1559
            Y   + P +   HT++V + G ++P SP++  +G     G+H  KV+  GPG+ER+  +A
Sbjct: 704  YACSYTPVKAIKHTIAVVWGGVNIPHSPYRVNIGQ----GSHPQKVKVFGPGVERSGLKA 759

Query: 1560 GVPAEFSIWTREAGAGGLAIAVEGPSKAEISFEDRKD----------GSCGVAYVVQEPG 1709
              P  F++   EAG G +++ ++    A +  ED +D           +  V YV    G
Sbjct: 760  NEPTHFTVDCTEAGEGDVSVGIK--CDARVLSEDEEDVDFDIIHNANDTFTVKYVPPAAG 817

Query: 1710 DYEVSVKFNEEHIPDSPFVVPVASPSGDARRLTVS--SLQESGLKVNQPASFAVSLNGA- 1880
             Y + V F  + IP SPF V V  PS DA ++      L ++G++  +P  F V   GA 
Sbjct: 818  RYTIKVLFASQEIPASPFRVKV-DPSHDASKVKAEGPGLSKAGVENGKPTHFTVYTKGAG 876

Query: 1881 KGAIDAKVHS--PSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKI 2054
            K  ++ + +S  P  A+++  + +     + V++ P + G   + V + G  IP SPF +
Sbjct: 877  KAPLNVQFNSPLPGDAVKDLDIIDNYDYSHTVKYTPTQQGNMQVLVTYGGDPIPKSPFTV 936

Query: 2055 RVGEPGHGGDPGLVSAYGAGLEGGV-TGSPAEFIVNTSNAGA-GALSVTIDGPSKVKMDC 2228
             V  P       L      GLE  V  G   EF V+T  AG  G L VTI  PS+  + C
Sbjct: 937  GVAAP-----LDLSKIKLNGLENRVEVGKDQEFTVDTRGAGGQGKLDVTILSPSRKVVPC 991

Query: 2229 QECP----EGYRVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSS 2396
               P    E     + P   G Y + + Y G + + GSP+    +               
Sbjct: 992  LVTPVTGRENSTAKFIPREEGLYAVDVTYDG-HPVPGSPYTVEAS--------------- 1035

Query: 2397 VFVDSLTKTXXXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKAGNNMLLV 2576
                                     SKV A G GL    VG+   FT+D   AG   L +
Sbjct: 1036 --------------------LPPDPSKVKAHGPGLEGGLVGKPAEFTIDTKGAGTGGLGL 1075

Query: 2577 GVHGPRTPCE-EILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYR 2729
             V G   PCE +I     G    SVSYL    GEY + + + + HIPGSP++
Sbjct: 1076 TVEG---PCEAKIECSDNGDGTCSVSYLPTKPGEYFVNILFEEVHIPGSPFK 1124



 Score =  283 bits (723), Expect = 9e-76
 Identities = 247/888 (27%), Positives = 379/888 (42%), Gaps = 43/888 (4%)
 Frame = +3

Query: 204  GEITGEVRMPSGKVAQPAITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFYVD 383
            GE+   ++ P G        D  DG     Y PS  G + + I +   HIP SP +  V 
Sbjct: 485  GELGVTMKGPKGLEELVKQKDFLDGVYAFEYYPSTPGRYSIAITWGGHHIPKSPFEVQVG 544

Query: 384  -YVNCGHVTAYGPGLSHGVVNKPAVFTVNTKDAGEGGLSLAIEGPSKAEISCTDNQDGTC 560
                   V A+GPGL  G+V + A F V +  +  G L  AIEGPS+A+I   D  DG+C
Sbjct: 545  PEAGMQKVRAWGPGLHGGIVGRSADFVVESIGSEVGSLGFAIEGPSQAKIEYNDQNDGSC 604

Query: 561  SVSYLPVLPGDYSILVKYNEQHIPGSPFTARV---TG----------DDSMRMSHLKVGS 701
             V Y P  PG+Y++ +  +++ I  SP+ A +   TG             +  S   V +
Sbjct: 605  DVKYWPKEPGEYAVHIMCDDEDIKDSPYMAFIHPATGGYNPDLVRAYGPGLEKSGCIVNN 664

Query: 702  AADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNG 881
             A+  ++  +   + L        G+     +K   +G    S+ P +  +H + V   G
Sbjct: 665  LAEFTVDPKDAGKAPLKIFAQDGEGQRIDIQMKNRMDGTYACSYTPVKAIKHTIAVVWGG 724

Query: 882  QHVASSPIPVVISQSEIGDASRVRVSGRGLHEG--HTFEPAEFIIDTRDAGYGGLSLSIE 1055
             ++  SP  V I Q       +V+V G G+        EP  F +D  +AG G +S+ I+
Sbjct: 725  VNIPHSPYRVNIGQG--SHPQKVKVFGPGVERSGLKANEPTHFTVDCTEAGEGDVSVGIK 782

Query: 1056 GPSKVDINTEDLED----------GTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVT 1205
              ++V   +ED ED           T  V Y P   G Y I + FA Q +P SPF VKV 
Sbjct: 783  CDARV--LSEDEEDVDFDIIHNANDTFTVKYVPPAAGRYTIKVLFASQEIPASPFRVKVD 840

Query: 1206 ---GEGRVKESITRRQRAPSVANVGSHCDLSLKIPEISIQDMTAQVTSPSGKSHEAEIVE 1376
                  +VK       +A       +H  +  K    +  ++      P     + +I++
Sbjct: 841  PSHDASKVKAEGPGLSKAGVENGKPTHFTVYTKGAGKAPLNVQFNSPLPGDAVKDLDIID 900

Query: 1377 GENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLE-RA 1553
              ++++ +++ P + G   V V Y G  +P SP  FTVG        K++    GLE R 
Sbjct: 901  NYDYSHTVKYTPTQQGNMQVLVTYGGDPIPKSP--FTVGVAAPLDLSKIKLN--GLENRV 956

Query: 1554 EAGVPAEFSIWTREAGA-GGLAIAVEGPSKAEI-----SFEDRKDGSCGVAYVVQEPGDY 1715
            E G   EF++ TR AG  G L + +  PS+  +         R++ +    ++ +E G Y
Sbjct: 957  EVGKDQEFTVDTRGAGGQGKLDVTILSPSRKVVPCLVTPVTGRENST--AKFIPREEGLY 1014

Query: 1716 EVSVKFNEEHIPDSPFVVPVASPSGDARRLTVSSLQESGLKVNQPASFAVSLNGA-KGAI 1892
             V V ++   +P SP+ V  + P   ++        E GL V +PA F +   GA  G +
Sbjct: 1015 AVDVTYDGHPVPGSPYTVEASLPPDPSKVKAHGPGLEGGL-VGKPAEFTIDTKGAGTGGL 1073

Query: 1893 DAKVHSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPG 2072
               V  P  A  EC  ++      +V ++P + G Y +++ F   HIPGSPFK  +  P 
Sbjct: 1074 GLTVEGPCEAKIEC--SDNGDGTCSVSYLPTKPGEYFVNILFEEVHIPGSPFKADIEMP- 1130

Query: 2073 HGGDPGLVSAYGAGLEGGVTGSPAEFIVNTSNAGAGALSV--TIDGPSKVKMDCQECPEG 2246
               DP  V A G GLE G  G      V+ S AG GAL +    D  +K ++  Q   +G
Sbjct: 1131 --FDPSKVVASGPGLEHGKVGEAGLLSVDCSEAGPGALGLEAVSDSGTKAEVSIQNNKDG 1188

Query: 2247 -YRVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSVFVDSLTKT 2423
             Y VTY P+  G Y +++KYGG        F ARV     V      +TS +        
Sbjct: 1189 TYAVTYVPLTAGMYTLTMKYGGEL---VPHFPARVKVEPAV------DTSRI-------- 1231

Query: 2424 XXXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVD---CSKAGNNMLLVGVHGPR 2594
                             KV   G+     +      FTVD    ++ G + +   +  P 
Sbjct: 1232 -----------------KVFGPGIEGKDVFREATTDFTVDSRPLTQVGGDHIKAHIANPS 1274

Query: 2595 TPCEEILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLV 2738
                E  V       Y V Y   +KG + + V + D  IP SP++V V
Sbjct: 1275 GASTECFVTDNADGTYQVEYTPFEKGLHVVEVTYDDVPIPNSPFKVAV 1322



 Score =  229 bits (583), Expect = 2e-59
 Identities = 234/840 (27%), Positives = 368/840 (43%), Gaps = 47/840 (5%)
 Frame = +3

Query: 354  PGSPLQFYVDYVNCGHVTAYGPGL--SHGVVNKPAVFTVNTKDAGEGGLSLAIEGP---- 515
            PG+PL+     +N     AYG G+  +  +V +PA FTV+T  AG+G + + +E P    
Sbjct: 244  PGAPLK---PKLNPKKARAYGRGIEPTGNMVKQPAKFTVDTISAGQGDVMVFVEDPEGNK 300

Query: 516  SKAEISCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARV---TGDDSMRMSH 686
             +A+++   +++ T SV YLP + G + + V +  QHI  SPF   V    GD S   + 
Sbjct: 301  EEAQVTPDSDKNKTYSVEYLPKVTGLHKVTVLFAGQHISKSPFEVSVDKAQGDASKVTAK 360

Query: 687  ----LKVGSAADIP----INISETDLSLLTATVVPPSGREEPCLLKRLRNGHV-GISFVP 839
                  VG+ A+ P    I  +   +  +   V  P G+    LL   +   V    + P
Sbjct: 361  GPGLEAVGNIANKPTYFDIYTAGAGVGDIGVEVEDPQGKNTVELLVEDKGNQVYRCVYKP 420

Query: 840  KETGEHLVHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEG--HTFEPAEFIID 1013
             + G H+V +   G  +  SP   V+   E  + +  R SGRGL        E  +F +D
Sbjct: 421  MQPGPHVVKIFFAGDTIPKSPF--VVQVGEACNPNACRASGRGLQPKGVRIRETTDFKVD 478

Query: 1014 TRDAGYGGLSLSIEGPSKVD--INTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSP 1187
            T+ AG G L ++++GP  ++  +  +D  DG     Y P+ PG Y I I +   H+P SP
Sbjct: 479  TKAAGSGELGVTMKGPKGLEELVKQKDFLDGVYAFEYYPSTPGRYSIAITWGGHHIPKSP 538

Query: 1188 FSVKVTGEGRVKESITRRQRAPSVAN--VGSHCDLSLKIPEISIQDMTAQVTSPSGKSHE 1361
            F V+V  E  +++    R   P +    VG   D  ++     +  +   +  PS    E
Sbjct: 539  FEVQVGPEAGMQKV---RAWGPGLHGGIVGRSADFVVESIGSEVGSLGFAIEGPSQAKIE 595

Query: 1362 AEIVEGENHTYC-IRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEG-GAHKVRAGG 1535
                  +N   C +++ P E G + V +    + +  SP+   + P   G     VRA G
Sbjct: 596  ---YNDQNDGSCDVKYWPKEPGEYAVHIMCDDEDIKDSPYMAFIHPATGGYNPDLVRAYG 652

Query: 1536 PGLERAEAGVP--AEFSIWTREAGAGGLAI-AVEGP-SKAEISFEDRKDGSCGVAYVVQE 1703
            PGLE++   V   AEF++  ++AG   L I A +G   + +I  ++R DG+   +Y   +
Sbjct: 653  PGLEKSGCIVNNLAEFTVDPKDAGKAPLKIFAQDGEGQRIDIQMKNRMDGTYACSYTPVK 712

Query: 1704 PGDYEVSVKFNEEHIPDSPFVVPVASPSGDAR-RLTVSSLQESGLKVNQPASFAVSLNGA 1880
               + ++V +   +IP SP+ V +   S   + ++    ++ SGLK N+P  F V    A
Sbjct: 713  AIKHTIAVVWGGVNIPHSPYRVNIGQGSHPQKVKVFGPGVERSGLKANEPTHFTVDCTEA 772

Query: 1881 -KGAI------DAKVHSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPG 2039
             +G +      DA+V S      +  +     D + V+++P   G Y I V F    IP 
Sbjct: 773  GEGDVSVGIKCDARVLSEDEEDVDFDIIHNANDTFTVKYVPPAAGRYTIKVLFASQEIPA 832

Query: 2040 SPFKIRVGEPGHGGDPGLVSAYGAGLE--GGVTGSPAEFIVNTSNAGAGALSVTIDGP-- 2207
            SPF+++V +P H  D   V A G GL   G   G P  F V T  AG   L+V  + P  
Sbjct: 833  SPFRVKV-DPSH--DASKVKAEGPGLSKAGVENGKPTHFTVYTKGAGKAPLNVQFNSPLP 889

Query: 2208 -SKVK-MD-CQECPEGYRVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHS 2378
               VK +D        + V YTP   G+  + + YGG   I  SPF   V          
Sbjct: 890  GDAVKDLDIIDNYDYSHTVKYTPTQQGNMQVLVTYGGD-PIPKSPFTVGVAA-------- 940

Query: 2379 LHETSSVFVDSLTKTXXXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKA- 2555
                                           SK+   GL  ++  VG+   FTVD   A 
Sbjct: 941  ---------------------------PLDLSKIKLNGLE-NRVEVGKDQEFTVDTRGAG 972

Query: 2556 GNNMLLVGVHGPRTPCEEILVKHVGSRLYSVS-YLLKDKGEYTLVVKWGDEHIPGSPYRV 2732
            G   L V +  P       LV  V  R  S + ++ +++G Y + V +    +PGSPY V
Sbjct: 973  GQGKLDVTILSPSRKVVPCLVTPVTGRENSTAKFIPREEGLYAVDVTYDGHPVPGSPYTV 1032



 Score =  139 bits (349), Expect = 2e-32
 Identities = 130/445 (29%), Positives = 195/445 (43%), Gaps = 15/445 (3%)
 Frame = +3

Query: 1449 KGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLERAEAGV--PAEFSIWTREAGAGGLAIA 1622
            K +  PG+P +  + P       K RA G G+E     V  PA+F++ T  AG G + + 
Sbjct: 239  KAKLKPGAPLKPKLNP------KKARAYGRGIEPTGNMVKQPAKFTVDTISAGQGDVMVF 292

Query: 1623 VEGPS----KAEISFEDRKDGSCGVAYVVQEPGDYEVSVKFNEEHIPDSPFVVPVASPSG 1790
            VE P     +A+++ +  K+ +  V Y+ +  G ++V+V F  +HI  SPF V V    G
Sbjct: 293  VEDPEGNKEEAQVTPDSDKNKTYSVEYLPKVTGLHKVTVLFAGQHISKSPFEVSVDKAQG 352

Query: 1791 DARRLTVS--SLQESGLKVNQPASFAVSLNGA-KGAIDAKVHSPSGA-LEECYVTEIDQD 1958
            DA ++T     L+  G   N+P  F +   GA  G I  +V  P G    E  V +    
Sbjct: 353  DASKVTAKGPGLEAVGNIANKPTYFDIYTAGAGVGDIGVEVEDPQGKNTVELLVEDKGNQ 412

Query: 1959 KYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPGLVSAYGAGLE--GGVT 2132
             Y   + P + G +++ + F G  IP SPF ++VGE     +P    A G GL+  G   
Sbjct: 413  VYRCVYKPMQPGPHVVKIFFAGDTIPKSPFVVQVGE---ACNPNACRASGRGLQPKGVRI 469

Query: 2133 GSPAEFIVNTSNAGAGALSVTIDGPSKVK--MDCQECPEG-YRVTYTPMAPGSYLISIKY 2303
                +F V+T  AG+G L VT+ GP  ++  +  ++  +G Y   Y P  PG Y I+I +
Sbjct: 470  RETTDFKVDTKAAGSGELGVTMKGPKGLEELVKQKDFLDGVYAFEYYPSTPGRYSIAITW 529

Query: 2304 GGPYHIGGSPFKARVTGHRLVSNHSLHETSSVFVDSLTKTXXXXXXXXXXXXXXXXSKVL 2483
            GG +HI  SPF+ +V                                          KV 
Sbjct: 530  GG-HHIPKSPFEVQV-----------------------------------GPEAGMQKVR 553

Query: 2484 AKGLGLSKAYVGQKGSFTVDCSKAGNNMLLVGVHGPRTPCEEILVKHVGSRLYSVSYLLK 2663
            A G GL    VG+   F V+   +    L   + GP     E   ++ GS    V Y  K
Sbjct: 554  AWGPGLHGGIVGRSADFVVESIGSEVGSLGFAIEGPSQAKIEYNDQNDGS--CDVKYWPK 611

Query: 2664 DKGEYTLVVKWGDEHIPGSPYRVLV 2738
            + GEY + +   DE I  SPY   +
Sbjct: 612  EPGEYAVHIMCDDEDIKDSPYMAFI 636


>ref|NP_001120959.1| filamin-C isoform b [Homo sapiens].
          Length = 2692

 Score =  797 bits (2058), Expect = 0.0
 Identities = 439/856 (51%), Positives = 557/856 (65%), Gaps = 24/856 (2%)
 Frame = +3

Query: 246  AQPAITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFYVDYVNCGHVTAYGPGL 425
            A+    DNKDGT TV Y P+  G + + +R+D+ HIPGSP    +   +    +    G 
Sbjct: 1869 AEITCKDNKDGTCTVSYLPTAPGDYSIIVRFDDKHIPGSPFTAKITGDDSMRTSQLNVGT 1928

Query: 426  SHGVVNKPAVFTVNTKDAGEGGLSLAIEGPSKAEISCTDNQ--DGTCSVSYLPVLPGDYS 599
            S  V  K     +   D  +  L+ +I  PS  E  C   +  +    +S+ P   G++ 
Sbjct: 1929 STDVSLK-----ITESDLSQ--LTASIRAPSGNEEPCLLKRLPNRHIGISFTPKEVGEHV 1981

Query: 600  ILVKYNEQHIPGSPFTARVTGDDSMRMSHLKVGS----------AADIPINISETDLSLL 749
            + V+ + +H+  SPF   V   +    S ++V             A+  ++        L
Sbjct: 1982 VSVRKSGKHVTNSPFKILVGPSEIGDASKVRVWGKGLSEGHTFQVAEFIVDTRNAGYGGL 2041

Query: 750  TATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNGQHVASSPIPVVISQSE 929
              ++  PS  +  C  + + +G   +++ P E G +++++K   +HV  SP  V ++   
Sbjct: 2042 GLSIEGPSKVDINC--EDMEDGTCKVTYCPTEPGTYIINIKFADKHVPGSPFTVKVTGE- 2098

Query: 930  IGDASRVRVSGRGLHEGHTFEPAEFIIDTR---DAGYGGLSLSIEGPSKVDINTEDLEDG 1100
                 R++ S     +  +        D        +  +  + E  ++    +      
Sbjct: 2099 ----GRMKESITRRRQAPSIATIGSTCDLNLKIPGNWFQMVSAQERLTRTFTRSSHTYTR 2154

Query: 1101 TCRVTYCPTEPGNYIINIKFADQ-HVPGSPFSVKVTGEGRVKE------SITRRQRAPSV 1259
            T R     T  G     ++  +   V G PF   V G+   +E      SITR+Q     
Sbjct: 2155 TERTEISKTRGGETKREVRVEESTQVGGDPFPA-VFGDFLGRERLGSFGSITRQQEG--- 2210

Query: 1260 ANVGSHCDLSLKIPEISIQDMTAQVTSPSGKSHEAEIVEGENHTYCIRFVPAEMGMHTVS 1439
                          E S QDMTAQVTSPSGK   AEIVEGE+  Y +RFVP EMG HTV+
Sbjct: 2211 --------------EASSQDMTAQVTSPSGKVEAAEIVEGEDSAYSVRFVPQEMGPHTVA 2256

Query: 1440 VKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLERAEAGVPAEFSIWTREAGAGGLAI 1619
            VKY+GQHVPGSPFQFTVGPLGEGGAHKVRAGG GLER  AGVPAEFSIWTREAGAGGL+I
Sbjct: 2257 VKYRGQHVPGSPFQFTVGPLGEGGAHKVRAGGTGLERGVAGVPAEFSIWTREAGAGGLSI 2316

Query: 1620 AVEGPSKAEISFEDRKDGSCGVAYVVQEPGDYEVSVKFNEEHIPDSPFVVPVASPSGDAR 1799
            AVEGPSKAEI+FEDRKDGSCGV+YVVQEPGDYEVS+KFN+EHIPDSPFVVPVAS S DAR
Sbjct: 2317 AVEGPSKAEIAFEDRKDGSCGVSYVVQEPGDYEVSIKFNDEHIPDSPFVVPVASLSDDAR 2376

Query: 1800 RLTVSSLQESGLKVNQPASFAVSLNGAKGAIDAKVHSPSGALEECYVTEIDQDKYAVRFI 1979
            RLTV+SLQE+GLKVNQPASFAV LNGA+G IDA+VH+PSGA+EECYV+E+D DK+ +RFI
Sbjct: 2377 RLTVTSLQETGLKVNQPASFAVQLNGARGVIDARVHTPSGAVEECYVSELDSDKHTIRFI 2436

Query: 1980 PRENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPGLVSAYGAGLEGGVTGSPAEFIVN 2159
            P ENGV+ IDVKFNG HIPGSPFKIRVGE    GDPGLVSAYG GLEGG TG  +EFIVN
Sbjct: 2437 PHENGVHSIDVKFNGAHIPGSPFKIRVGEQSQAGDPGLVSAYGPGLEGGTTGVSSEFIVN 2496

Query: 2160 TSNAGAGALSVTIDGPSKVKMDCQECPEGYRVTYTPMAPGSYLISIKYGGPYHIGGSPFK 2339
            T NAG+GALSVTIDGPSKV++DC+ECPEG+ VTYTPMAPG+YLI+IKYGGP HI GSPFK
Sbjct: 2497 TLNAGSGALSVTIDGPSKVQLDCRECPEGHVVTYTPMAPGNYLIAIKYGGPQHIVGSPFK 2556

Query: 2340 ARVTGHRLVSNHSLHETSSVFVDSLTK--TXXXXXXXXXXXXXXXXSKVLAKGLGLSKAY 2513
            A+VTG RL   HSLHETS+V V+++TK  +                SKV+ +G GLS+A+
Sbjct: 2557 AKVTGPRLSGGHSLHETSTVLVETVTKSSSSRGSSYSSIPKFSSDASKVVTRGPGLSQAF 2616

Query: 2514 VGQKGSFTVDCSKAGNNMLLVGVHGPRTPCEEILVKHVGSRLYSVSYLLKDKGEYTLVVK 2693
            VGQK SFTVDCSKAG NM++VGVHGP+TPCEE+ VKH+G+R+Y+V+Y +K+KG+Y L+VK
Sbjct: 2617 VGQKNSFTVDCSKAGTNMMMVGVHGPKTPCEEVYVKHMGNRVYNVTYTVKEKGDYILIVK 2676

Query: 2694 WGDEHIPGSPYRVLVP 2741
            WGDE +PGSP++V VP
Sbjct: 2677 WGDESVPGSPFKVKVP 2692



 Score =  697 bits (1800), Expect = 0.0
 Identities = 406/887 (45%), Positives = 526/887 (59%), Gaps = 12/887 (1%)
 Frame = +3

Query: 114  APERPLVGVNGLDVTSLRPFDLVIPFTIKKGEITGEVRMPSGKVAQPAITDNKDGTVTVR 293
            A E P+V V  ++ + LRPF+LVIPF ++KGE+TGEVRMPSGK A+P ITDNKDGT+TVR
Sbjct: 1734 ATEEPVVPVEPME-SMLRPFNLVIPFAVQKGELTGEVRMPSGKTARPNITDNKDGTITVR 1792

Query: 294  YAPSEAGLHEMDIRYDNMHIPGSPLQFYVDYVNCGHVTAYGPGLSHGVVNKPAVFTVNTK 473
            YAP+E GLH+M I+YD  HIPGSPLQFYVD +N  HV+AYGPGLSHG+VNKPA FT+ TK
Sbjct: 1793 YAPTEKGLHQMGIKYDGNHIPGSPLQFYVDAINSRHVSAYGPGLSHGMVNKPATFTIVTK 1852

Query: 474  DAGEGGLSLAIEGPSKAEISCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTAR 653
            DAGEGGLSLA+EGPSKAEI+C DN+DGTC+VSYLP  PGDYSI+V+++++HIPGSPFTA+
Sbjct: 1853 DAGEGGLSLAVEGPSKAEITCKDNKDGTCTVSYLPTAPGDYSIIVRFDDKHIPGSPFTAK 1912

Query: 654  VTGDDSMRMSHLKVGSAADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISF 833
            +TGDDSMR S L VG++ D+ + I+E+DLS LTA++  PSG EEPCLLKRL N H+GISF
Sbjct: 1913 ITGDDSMRTSQLNVGTSTDVSLKITESDLSQLTASIRAPSGNEEPCLLKRLPNRHIGISF 1972

Query: 834  VPKETGEHLVHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEGHTFEPAEFIID 1013
             PKE GEH+V V+K+G+HV +SP  +++  SEIGDAS+VRV G+GL EGHTF+ AEFI+D
Sbjct: 1973 TPKEVGEHVVSVRKSGKHVTNSPFKILVGPSEIGDASKVRVWGKGLSEGHTFQVAEFIVD 2032

Query: 1014 TRDAGYGGLSLSIEGPSKVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFS 1193
            TR+AGYGGL LSIEGPSKVDIN ED+EDGTC+VTYCPTEPG YIINIKFAD+HVPGSPF+
Sbjct: 2033 TRNAGYGGLGLSIEGPSKVDINCEDMEDGTCKVTYCPTEPGTYIINIKFADKHVPGSPFT 2092

Query: 1194 VKVTGEGRVKESITRRQRAPSVANVGSHCDLSLKIPEISIQDMTAQVTSPSGKSHEAEIV 1373
            VKVTGEGR+KESITRR++APS+A +GS CDL+LKIP    Q ++AQ       +  +   
Sbjct: 2093 VKVTGEGRMKESITRRRQAPSIATIGSTCDLNLKIPGNWFQMVSAQERLTRTFTRSSHTY 2152

Query: 1374 EGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPG-LER 1550
                 T   +    E     V V+   Q V G PF    G        + R G  G + R
Sbjct: 2153 TRTERTEISKTRGGET-KREVRVEESTQ-VGGDPFPAVFGDF----LGRERLGSFGSITR 2206

Query: 1551 AEAGVPAEFSIWTREAGAGGLAIAVEGPS-KAEIS-FEDRKDGSCGVAYVVQEPGDYEVS 1724
             + G          EA +  +   V  PS K E +   + +D +  V +V QE G + V+
Sbjct: 2207 QQEG----------EASSQDMTAQVTSPSGKVEAAEIVEGEDSAYSVRFVPQEMGPHTVA 2256

Query: 1725 VKFNEEHIPDSPFVVPVAS-PSGDARRLTVSSLQESGLKVNQPASFAV-SLNGAKGAIDA 1898
            VK+  +H+P SPF   V     G A ++              PA F++ +     G +  
Sbjct: 2257 VKYRGQHVPGSPFQFTVGPLGEGGAHKVRAGGTGLERGVAGVPAEFSIWTREAGAGGLSI 2316

Query: 1899 KVHSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGHG 2078
             V  PS A  E    +       V ++ +E G Y + +KFN  HIP SPF + V      
Sbjct: 2317 AVEGPSKA--EIAFEDRKDGSCGVSYVVQEPGDYEVSIKFNDEHIPDSPFVVPVA--SLS 2372

Query: 2079 GDPGLVSAYGAGLEGGVTGSPAEFIVNTSNAGAGALSVTIDGPSKVKMDC---QECPEGY 2249
             D   ++       G     PA F V   N   G +   +  PS    +C   +   + +
Sbjct: 2373 DDARRLTVTSLQETGLKVNQPASFAVQL-NGARGVIDARVHTPSGAVEECYVSELDSDKH 2431

Query: 2250 RVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSVFVDSLTKTXX 2429
             + + P   G + I +K+ G  HI GSPFK RV       +  L                
Sbjct: 2432 TIRFIPHENGVHSIDVKFNGA-HIPGSPFKIRVGEQSQAGDPGL---------------- 2474

Query: 2430 XXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKAGNNMLLVGVHGP---RTP 2600
                            V A G GL     G    F V+   AG+  L V + GP   +  
Sbjct: 2475 ----------------VSAYGPGLEGGTTGVSSEFIVNTLNAGSGALSVTIDGPSKVQLD 2518

Query: 2601 CEEILVKHVGSRLYSVSYLLKDKGEYTLVVKW-GDEHIPGSPYRVLV 2738
            C E    HV      V+Y     G Y + +K+ G +HI GSP++  V
Sbjct: 2519 CRECPEGHV------VTYTPMAPGNYLIAIKYGGPQHIVGSPFKAKV 2559



 Score =  419 bits (1077), Expect = e-117
 Identities = 255/733 (34%), Positives = 385/733 (52%), Gaps = 30/733 (4%)
 Frame = +3

Query: 246  AQPAITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFYV-DYVNCGHVTAYGPG 422
            A+ +  DNKDG+ TV Y P   G ++++I +    IPGSP +  V D V+ G V   GPG
Sbjct: 1393 AKMSCKDNKDGSCTVEYIPFTPGDYDVNITFGGRPIPGSPFRVPVKDVVDPGKVKCSGPG 1452

Query: 423  LSHGV-VNKPAVFTVNTKDAGEGGLSLAIEGPSKAE--ISCTDNQDGTCSVSYLPVLPGD 593
            L  GV    P  FTV+   AG   L +A+ GP+     +   DN DGT +V Y P   G 
Sbjct: 1453 LGAGVRARVPQTFTVDCSQAGRAPLQVAVLGPTGVAEPVEVRDNGDGTHTVHYTPATDGP 1512

Query: 594  YSILVKYNEQHIPGSPFTARV----------TGDDSMRMSHLKVGSAADIPINISETDLS 743
            Y++ VKY +Q +P SPF  +V               +  S +      +  I+  +    
Sbjct: 1513 YTVAVKYADQEVPRSPFKIKVLPAHDASKVRASGPGLNASGIPASLPVEFTIDARDAGEG 1572

Query: 744  LLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNGQHVASSPIPVVISQ 923
            LLT  ++ P G+ +   ++   +G   +S++P  +G + + +K  G  +  SP    I  
Sbjct: 1573 LLTVQILDPEGKPKKANIRDNGDGTYTVSYLPDMSGRYTITIKYGGDEIPYSPFR--IHA 1630

Query: 924  SEIGDASR----VRVSGRGLHEGHTFEPAEFI-------IDTRDAGYGGLSLSIEGP--S 1064
               GDAS+    V + G GL  G    P   I       +D + AG G ++ ++  P  +
Sbjct: 1631 LPTGDASKCLVTVSIGGHGL--GACLGPRIQIGQETVITVDAKAAGEGKVTCTVSTPDGA 1688

Query: 1065 KVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTGEGRVKESITRRQ 1244
            ++D++  +  DGT  + Y   EPG Y+I I+F  +H+P SPF V  T E  V        
Sbjct: 1689 ELDVDVVENHDGTFDIYYTAPEPGKYVITIRFGGEHIPNSPFHVLATEEPVVPVEPMESM 1748

Query: 1245 RAPSVANVGSHCDLSLKIP-EISIQDMTAQVTSPSGKSHEAEIVEGENHTYCIRFVPAEM 1421
              P           +L IP  +   ++T +V  PSGK+    I + ++ T  +R+ P E 
Sbjct: 1749 LRP----------FNLVIPFAVQKGELTGEVRMPSGKTARPNITDNKDGTITVRYAPTEK 1798

Query: 1422 GMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLERAEAGVPAEFSIWTREAG 1601
            G+H + +KY G H+PGSP QF V  +    +  V A GPGL       PA F+I T++AG
Sbjct: 1799 GLHQMGIKYDGNHIPGSPLQFYVDAIN---SRHVSAYGPGLSHGMVNKPATFTIVTKDAG 1855

Query: 1602 AGGLAIAVEGPSKAEISFEDRKDGSCGVAYVVQEPGDYEVSVKFNEEHIPDSPFVVPVAS 1781
             GGL++AVEGPSKAEI+ +D KDG+C V+Y+   PGDY + V+F+++HIP SPF   +  
Sbjct: 1856 EGGLSLAVEGPSKAEITCKDNKDGTCTVSYLPTAPGDYSIIVRFDDKHIPGSPFTAKI-- 1913

Query: 1782 PSGDARRLTVSSLQESGLKVNQPASFAVSLNGAK-GAIDAKVHSPSGALEECYVTEIDQD 1958
             +GD       S++ S L V      ++ +  +    + A + +PSG  E C +  +   
Sbjct: 1914 -TGD------DSMRTSQLNVGTSTDVSLKITESDLSQLTASIRAPSGNEEPCLLKRLPNR 1966

Query: 1959 KYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPGLVSAYGAGLEGGVTGS 2138
               + F P+E G +++ V+ +G H+  SPFKI VG P   GD   V  +G GL  G T  
Sbjct: 1967 HIGISFTPKEVGEHVVSVRKSGKHVTNSPFKILVG-PSEIGDASKVRVWGKGLSEGHTFQ 2025

Query: 2139 PAEFIVNTSNAGAGALSVTIDGPSKVKMDCQECPEGY-RVTYTPMAPGSYLISIKYGGPY 2315
             AEFIV+T NAG G L ++I+GPSKV ++C++  +G  +VTY P  PG+Y+I+IK+    
Sbjct: 2026 VAEFIVDTRNAGYGGLGLSIEGPSKVDINCEDMEDGTCKVTYCPTEPGTYIINIKFADK- 2084

Query: 2316 HIGGSPFKARVTG 2354
            H+ GSPF  +VTG
Sbjct: 2085 HVPGSPFTVKVTG 2097



 Score =  359 bits (922), Expect = 7e-99
 Identities = 276/885 (31%), Positives = 417/885 (47%), Gaps = 40/885 (4%)
 Frame = +3

Query: 204  GEITGEVRMPSGK--VAQPAITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFY 377
            G++   +  P G+    + A+ D  D T    Y P+  G H + + +    I  SP   +
Sbjct: 408  GDVAVVIVDPQGRRDTVEVALEDKGDSTFRCTYRPAMEGPHTVHVAFAGAPITRSPFPVH 467

Query: 378  V-DYVNCGHVTAYGPGLS-HGV-VNKPAVFTVNTKDAGEGGLSLAIEGPSKAE--ISCTD 542
            V +  N     A G GL   GV V + A F V TK AG G L + ++GP   E  +   +
Sbjct: 468  VSEACNPNACRASGRGLQPKGVRVKEVADFKVFTKGAGSGELKVTVKGPKGTEEPVKVRE 527

Query: 543  NQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARVTGDDSMRMSHL--------KVG 698
              DG     Y PV+PG Y + + +    IP SPF  +V+ +  ++            +VG
Sbjct: 528  AGDGVFECEYYPVVPGKYVVTITWGGYAIPRSPFEVQVSPEAGVQKVRAWGPGLETGQVG 587

Query: 699  SAADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKN 878
             +AD  +    T++  L  ++  PS  +  C  K   +G   + + P E GE+ VHV  +
Sbjct: 588  KSADFVVEAIGTEVGTLGFSIEGPSQAKIECDDKG--DGSCDVRYWPTEPGEYAVHVICD 645

Query: 879  GQHVASSP-IPVVISQSEIGDASRVRVSGRGLHEGHTF--EPAEFIIDTRDAGYGGLSLS 1049
             + +  SP I  ++         +V+  G GL        +PAEF ID R AG G L L 
Sbjct: 646  DEDIRDSPFIAHILPAPPDCFPDKVKAFGPGLEPTGCIVDKPAEFTIDARAAGKGDLKLY 705

Query: 1050 IEGPS--KVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTGEGRVK 1223
             +      +DI      DGT R +Y PT+P  + I I +   +VP SPF V V GEG   
Sbjct: 706  AQDADGCPIDIKVIPNGDGTFRCSYVPTKPIKHTIIISWGGVNVPKSPFRVNV-GEGSHP 764

Query: 1224 ESITRRQRAPSVANVGSHCD----LSLKIPEISIQDMTAQ------VTSPSGKSHEAEIV 1373
            E +  +   P V   G   +     ++   E    D++        V  P+    + +I+
Sbjct: 765  ERV--KVYGPGVEKTGLKANEPTYFTVDCSEAGQGDVSIGIKCAPGVVGPAEADIDFDII 822

Query: 1374 EGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLERA 1553
            + +N T+ +++ P   G +T+ V +  Q +P SPF   V P  +  A KV+A GPGL R 
Sbjct: 823  KNDNDTFTVKYTPPGAGRYTIMVLFANQEIPASPFHIKVDPSHD--ASKVKAEGPGLNRT 880

Query: 1554 --EAGVPAEFSIWTREAGAGGLAIAVEGPSKAEI--SFE--DRKDGSCGVAYVVQEPGDY 1715
              E G P  F++ T+ AG   L +   G +K E+   FE  D  D S  V Y   + G+ 
Sbjct: 881  GVEVGKPTHFTVLTKGAGKAKLDVQFAGTAKGEVVRDFEIIDNHDYSYTVKYTAVQQGNM 940

Query: 1716 EVSVKFNEEHIPDSPFVVPVASPSGDARRLTVSSLQESGLKVNQPASFAVSLNGA--KGA 1889
             V+V +  + +P SPFVV VA P  D  ++ V  L  S + V Q  +F+V+  GA  +G 
Sbjct: 941  AVTVTYGGDPVPKSPFVVNVAPPL-DLSKIKVQGLN-SKVAVGQEQAFSVNTRGAGGQGQ 998

Query: 1890 IDAKVHSPSGALEECYVTEID-QDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGE 2066
            +D ++ SPS     C +      +  AVR++P E G Y +D+ ++G  +PGSPF +    
Sbjct: 999  LDVRMTSPSRRPIPCKLEPGGGAEAQAVRYMPPEEGPYKVDITYDGHPVPGSPFAVEGVL 1058

Query: 2067 PGHGGDPGLVSAYGAGLEGGVTGSPAEFIVNTSNAGAGALSVTIDGPSKVKMDCQECPEG 2246
            P    DP  V AYG GL+GG+ G+PA F ++T  AG G L +T++GP + K++CQ+  +G
Sbjct: 1059 PP---DPSKVCAYGPGLKGGLVGTPAPFSIDTKGAGTGGLGLTVEGPCEAKIECQDNGDG 1115

Query: 2247 Y-RVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSVFVDSLTKT 2423
               V+Y P  PG Y I+I +    HI GSPFKA +                VF       
Sbjct: 1116 SCAVSYLPTEPGEYTINILFAEA-HIPGSPFKATI--------------RPVF------- 1153

Query: 2424 XXXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKAGNNMLLVGVHGPRTPC 2603
                            SKV A G GL +  VG+  +FTVDCS+AG   L + +       
Sbjct: 1154 --------------DPSKVRASGPGLERGKVGEAATFTVDCSEAGEAELTIEILSDAGVK 1199

Query: 2604 EEILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLV 2738
             E+L+ +     Y ++Y     G YT+ +K+G   +P  P RV V
Sbjct: 1200 AEVLIHNNADGTYHITYSPAFPGTYTITIKYGGHPVPKFPTRVHV 1244



 Score =  327 bits (839), Expect = 3e-89
 Identities = 250/881 (28%), Positives = 402/881 (45%), Gaps = 35/881 (3%)
 Frame = +3

Query: 201  KGEITGEVRMPSGKVAQPAITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFYV 380
            + E+T E+   +G  A+  I +N DGT  + Y+P+  G + + I+Y    +P  P + +V
Sbjct: 1185 EAELTIEILSDAGVKAEVLIHNNADGTYHITYSPAFPGTYTITIKYGGHPVPKFPTRVHV 1244

Query: 381  D-YVNCGHVTAYGPGLS-HGVVNKPAV-FTVNTKD---AGEGGLSLAIEGPS--KAEISC 536
               V+   V   GPG+  HGV+ +    FTV+ +     G   ++  +  PS  K +   
Sbjct: 1245 QPAVDTSGVKVSGPGVEPHGVLREVTTEFTVDARSLTATGGNHVTARVLNPSGAKTDTYV 1304

Query: 537  TDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARVT-GDDSMRMSHLKVG----- 698
            TDN DGT  V Y     G + + V Y+E  +P SPF   VT G D  R+     G     
Sbjct: 1305 TDNGDGTYRVQYTAYEEGVHLVEVLYDEVAVPKSPFRVGVTEGCDPTRVRAFGPGLEGGL 1364

Query: 699  --SAADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVK 872
               A    +         L   +  PS  +  C  K  ++G   + ++P   G++ V++ 
Sbjct: 1365 VNKANRFTVETRGAGTGGLGLAIEGPSEAKMSC--KDNKDGSCTVEYIPFTPGDYDVNIT 1422

Query: 873  KNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEG-HTFEPAEFIIDTRDAGYGGLSLS 1049
              G+ +  SP  V +   ++ D  +V+ SG GL  G     P  F +D   AG   L ++
Sbjct: 1423 FGGRPIPGSPFRVPVK--DVVDPGKVKCSGPGLGAGVRARVPQTFTVDCSQAGRAPLQVA 1480

Query: 1050 IEGPSKV--DINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTGEGRVK 1223
            + GP+ V   +   D  DGT  V Y P   G Y + +K+ADQ VP SPF +KV       
Sbjct: 1481 VLGPTGVAEPVEVRDNGDGTHTVHYTPATDGPYTVAVKYADQEVPRSPFKIKVLP---AH 1537

Query: 1224 ESITRRQRAPSVANVGSHCDLSLKIPEISIQD-----MTAQVTSPSGKSHEAEIVEGENH 1388
            ++   R   P +   G    L ++   I  +D     +T Q+  P GK  +A I +  + 
Sbjct: 1538 DASKVRASGPGLNASGIPASLPVEFT-IDARDAGEGLLTVQILDPEGKPKKANIRDNGDG 1596

Query: 1389 TYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGG--AHKVRAGGPGL-----E 1547
            TY + ++P   G +T+++KY G  +P SPF+    P G+       V  GG GL      
Sbjct: 1597 TYTVSYLPDMSGRYTITIKYGGDEIPYSPFRIHALPTGDASKCLVTVSIGGHGLGACLGP 1656

Query: 1548 RAEAGVPAEFSIWTREAGAGGLAIAVEGPSKAEISFE--DRKDGSCGVAYVVQEPGDYEV 1721
            R + G     ++  + AG G +   V  P  AE+  +  +  DG+  + Y   EPG Y +
Sbjct: 1657 RIQIGQETVITVDAKAAGEGKVTCTVSTPDGAELDVDVVENHDGTFDIYYTAPEPGKYVI 1716

Query: 1722 SVKFNEEHIPDSPF-VVPVASPSGDARRLTVSSLQESGLKVNQPASFAVSLNGAKGAIDA 1898
            +++F  EHIP+SPF V+    P      + V  ++      N    FAV     KG +  
Sbjct: 1717 TIRFGGEHIPNSPFHVLATEEPV-----VPVEPMESMLRPFNLVIPFAVQ----KGELTG 1767

Query: 1899 KVHSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGHG 2078
            +V  PSG      +T+       VR+ P E G++ + +K++G HIPGSP +  V      
Sbjct: 1768 EVRMPSGKTARPNITDNKDGTITVRYAPTEKGLHQMGIKYDGNHIPGSPLQFYV----DA 1823

Query: 2079 GDPGLVSAYGAGLEGGVTGSPAEFIVNTSNAGAGALSVTIDGPSKVKMDCQECPEG-YRV 2255
             +   VSAYG GL  G+   PA F + T +AG G LS+ ++GPSK ++ C++  +G   V
Sbjct: 1824 INSRHVSAYGPGLSHGMVNKPATFTIVTKDAGEGGLSLAVEGPSKAEITCKDNKDGTCTV 1883

Query: 2256 TYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSVFVDSLTKTXXXX 2435
            +Y P APG Y I +++    HI GSPF A++TG                 D   +T    
Sbjct: 1884 SYLPTAPGDYSIIVRFDDK-HIPGSPFTAKITG-----------------DDSMRT---- 1921

Query: 2436 XXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKAGNNMLLVGVHGPRTPCEEIL 2615
                                  S+  VG     ++  +++  + L   +  P    E  L
Sbjct: 1922 ----------------------SQLNVGTSTDVSLKITESDLSQLTASIRAPSGNEEPCL 1959

Query: 2616 VKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLV 2738
            +K + +R   +S+  K+ GE+ + V+   +H+  SP+++LV
Sbjct: 1960 LKRLPNRHIGISFTPKEVGEHVVSVRKSGKHVTNSPFKILV 2000



 Score =  318 bits (816), Expect = 1e-86
 Identities = 258/861 (29%), Positives = 385/861 (44%), Gaps = 35/861 (4%)
 Frame = +3

Query: 258  ITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFYV-DYVNCGHVTAYGPGLSHG 434
            I DN D + TV+Y   + G   + + Y    +P SP    V   ++   +   G   S  
Sbjct: 920  IIDNHDYSYTVKYTAVQQGNMAVTVTYGGDPVPKSPFVVNVAPPLDLSKIKVQGLN-SKV 978

Query: 435  VVNKPAVFTVNTKDAG-EGGLSLAIEGPSKAEISCTDNQDGTC---SVSYLPVLPGDYSI 602
             V +   F+VNT+ AG +G L + +  PS+  I C     G     +V Y+P   G Y +
Sbjct: 979  AVGQEQAFSVNTRGAGGQGQLDVRMTSPSRRPIPCKLEPGGGAEAQAVRYMPPEEGPYKV 1038

Query: 603  LVKYNEQHIPGSPFTAR--VTGDDSMRMSH---LK---VGSAADIPINISETDLSLLTAT 758
             + Y+   +PGSPF     +  D S   ++   LK   VG+ A   I+        L  T
Sbjct: 1039 DITYDGHPVPGSPFAVEGVLPPDPSKVCAYGPGLKGGLVGTPAPFSIDTKGAGTGGLGLT 1098

Query: 759  VVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNGQHVASSPIPVVISQSEIGD 938
            V  P   +  C  +   +G   +S++P E GE+ +++     H+  SP    I    + D
Sbjct: 1099 VEGPCEAKIEC--QDNGDGSCAVSYLPTEPGEYTINILFAEAHIPGSPFKATIRP--VFD 1154

Query: 939  ASRVRVSGRGLHEGHTFEPAEFIIDTRDAGYGGLSLSI--EGPSKVDINTEDLEDGTCRV 1112
             S+VR SG GL  G   E A F +D  +AG   L++ I  +   K ++   +  DGT  +
Sbjct: 1155 PSKVRASGPGLERGKVGEAATFTVDCSEAGEAELTIEILSDAGVKAEVLIHNNADGTYHI 1214

Query: 1113 TYCPTEPGNYIINIKFADQHVPGSPF-----------SVKVTGEGRVKESITRRQRAPSV 1259
            TY P  PG Y I IK+    VP  P             VKV+G G     + R       
Sbjct: 1215 TYSPAFPGTYTITIKYGGHPVPKFPTRVHVQPAVDTSGVKVSGPGVEPHGVLREVTTEFT 1274

Query: 1260 ANVGSHCDLSLKIPEISIQDMTAQVTSPSGKSHEAEIVEGENHTYCIRFVPAEMGMHTVS 1439
             +  S       +       +TA+V +PSG   +  + +  + TY +++   E G+H V 
Sbjct: 1275 VDARS-------LTATGGNHVTARVLNPSGAKTDTYVTDNGDGTYRVQYTAYEEGVHLVE 1327

Query: 1440 VKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLERAEAGVPAEFSIWTREAGAGGLAI 1619
            V Y    VP SPF+  VG        +VRA GPGLE         F++ TR AG GGL +
Sbjct: 1328 VLYDEVAVPKSPFR--VGVTEGCDPTRVRAFGPGLEGGLVNKANRFTVETRGAGTGGLGL 1385

Query: 1620 AVEGPSKAEISFEDRKDGSCGVAYVVQEPGDYEVSVKFNEEHIPDSPFVVPVASPSGDAR 1799
            A+EGPS+A++S +D KDGSC V Y+   PGDY+V++ F    IP SPF VPV       +
Sbjct: 1386 AIEGPSEAKMSCKDNKDGSCTVEYIPFTPGDYDVNITFGGRPIPGSPFRVPVKDVVDPGK 1445

Query: 1800 RLTVSSLQESGLKVNQPASFAVSLNGA-KGAIDAKVHSPSGALEECYVTEIDQDKYAVRF 1976
                     +G++   P +F V  + A +  +   V  P+G  E   V +     + V +
Sbjct: 1446 VKCSGPGLGAGVRARVPQTFTVDCSQAGRAPLQVAVLGPTGVAEPVEVRDNGDGTHTVHY 1505

Query: 1977 IPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPGLVSAYGAGLE-GGVTGS-PAEF 2150
             P  +G Y + VK+    +P SPFKI+V  P H  D   V A G GL   G+  S P EF
Sbjct: 1506 TPATDGPYTVAVKYADQEVPRSPFKIKV-LPAH--DASKVRASGPGLNASGIPASLPVEF 1562

Query: 2151 IVNTSNAGAGALSVTIDGP--SKVKMDCQECPEG-YRVTYTPMAPGSYLISIKYGGPYHI 2321
             ++  +AG G L+V I  P     K + ++  +G Y V+Y P   G Y I+IKYGG   I
Sbjct: 1563 TIDARDAGEGLLTVQILDPEGKPKKANIRDNGDGTYTVSYLPDMSGRYTITIKYGGD-EI 1621

Query: 2322 GGSPFKARVTGHRLVSNHSLHETSSVFVDSLTKTXXXXXXXXXXXXXXXXSKVLAKGLGL 2501
              SPF+     H L +  +     +V +                            GLG 
Sbjct: 1622 PYSPFRI----HALPTGDASKCLVTVSIG-------------------------GHGLGA 1652

Query: 2502 ---SKAYVGQKGSFTVDCSKAGNNMLLVGVHGPRTPCEEILVKHVGSRLYSVSYLLKDKG 2672
                +  +GQ+   TVD   AG   +   V  P     ++ V       + + Y   + G
Sbjct: 1653 CLGPRIQIGQETVITVDAKAAGEGKVTCTVSTPDGAELDVDVVENHDGTFDIYYTAPEPG 1712

Query: 2673 EYTLVVKWGDEHIPGSPYRVL 2735
            +Y + +++G EHIP SP+ VL
Sbjct: 1713 KYVITIRFGGEHIPNSPFHVL 1733



 Score =  305 bits (782), Expect = 1e-82
 Identities = 266/894 (29%), Positives = 407/894 (45%), Gaps = 48/894 (5%)
 Frame = +3

Query: 201  KGEITGEVRMPSGKVAQPAITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFYV 380
            KG++    +   G      +  N DGT    Y P++   H + I +  +++P SP +  V
Sbjct: 699  KGDLKLYAQDADGCPIDIKVIPNGDGTFRCSYVPTKPIKHTIIISWGGVNVPKSPFRVNV 758

Query: 381  -DYVNCGHVTAYGPGLSHG--VVNKPAVFTVNTKDAGEGGLSLAIE------GPSKAEI- 530
             +  +   V  YGPG+       N+P  FTV+  +AG+G +S+ I+      GP++A+I 
Sbjct: 759  GEGSHPERVKVYGPGVEKTGLKANEPTYFTVDCSEAGQGDVSIGIKCAPGVVGPAEADID 818

Query: 531  -SCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARVTGDDSMRMSHLKVGSAA 707
                 N + T +V Y P   G Y+I+V +  Q IP SPF  +V  D S   S +K   A 
Sbjct: 819  FDIIKNDNDTFTVKYTPPGAGRYTIMVLFANQEIPASPFHIKV--DPSHDASKVK---AE 873

Query: 708  DIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVG-----------------ISFV 836
               +N +  ++   T   V   G  +  L  +      G                 + + 
Sbjct: 874  GPGLNRTGVEVGKPTHFTVLTKGAGKAKLDVQFAGTAKGEVVRDFEIIDNHDYSYTVKYT 933

Query: 837  PKETGEHLVHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEGHTFEPAEFIIDT 1016
              + G   V V   G  V  SP   V++ +   D S+++V G         E A F ++T
Sbjct: 934  AVQQGNMAVTVTYGGDPVPKSPF--VVNVAPPLDLSKIKVQGLNSKVAVGQEQA-FSVNT 990

Query: 1017 RDA-GYGGLSLSIEGPSKVDINTEDLEDG----TCRVTYCPTEPGNYIINIKFADQHVPG 1181
            R A G G L + +  PS+  I  + LE G       V Y P E G Y ++I +    VPG
Sbjct: 991  RGAGGQGQLDVRMTSPSRRPIPCK-LEPGGGAEAQAVRYMPPEEGPYKVDITYDGHPVPG 1049

Query: 1182 SPFSVKVTGEGRVKESITR-RQRAPSVAN--VGSHCDLSLKIPEISIQDMTAQVTSPSGK 1352
            SPF+V    EG +    ++     P +    VG+    S+         +   V  P   
Sbjct: 1050 SPFAV----EGVLPPDPSKVCAYGPGLKGGLVGTPAPFSIDTKGAGTGGLGLTVEGPCEA 1105

Query: 1353 SHEAEIVEGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAG 1532
              E +  +  + +  + ++P E G +T+++ +   H+PGSPF+ T+ P+ +    KVRA 
Sbjct: 1106 KIECQ--DNGDGSCAVSYLPTEPGEYTINILFAEAHIPGSPFKATIRPVFD--PSKVRAS 1161

Query: 1533 GPGLERAEAGVPAEFSIWTREAGAGGLAIAV--EGPSKAEISFEDRKDGSCGVAYVVQEP 1706
            GPGLER + G  A F++   EAG   L I +  +   KAE+   +  DG+  + Y    P
Sbjct: 1162 GPGLERGKVGEAATFTVDCSEAGEAELTIEILSDAGVKAEVLIHNNADGTYHITYSPAFP 1221

Query: 1707 GDYEVSVKFNEEHIPDSPFVVPVASPSGDARRLTVS--SLQESGLKVNQPASFAV---SL 1871
            G Y +++K+    +P  P  V V  P+ D   + VS   ++  G+       F V   SL
Sbjct: 1222 GTYTITIKYGGHPVPKFPTRVHV-QPAVDTSGVKVSGPGVEPHGVLREVTTEFTVDARSL 1280

Query: 1872 NGAKG-AIDAKVHSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPF 2048
                G  + A+V +PSGA  + YVT+     Y V++   E GV+L++V ++   +P SPF
Sbjct: 1281 TATGGNHVTARVLNPSGAKTDTYVTDNGDGTYRVQYTAYEEGVHLVEVLYDEVAVPKSPF 1340

Query: 2049 KIRVGEPGHGGDPGLVSAYGAGLEGGVTGSPAEFIVNTSNAGAGALSVTIDGPSKVKMDC 2228
            ++ V E   G DP  V A+G GLEGG+      F V T  AG G L + I+GPS+ KM C
Sbjct: 1341 RVGVTE---GCDPTRVRAFGPGLEGGLVNKANRFTVETRGAGTGGLGLAIEGPSEAKMSC 1397

Query: 2229 QECPEG-YRVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSVFV 2405
            ++  +G   V Y P  PG Y ++I +GG   I GSPF+  V                  V
Sbjct: 1398 KDNKDGSCTVEYIPFTPGDYDVNITFGG-RPIPGSPFRVPVKD---------------VV 1441

Query: 2406 DSLTKTXXXXXXXXXXXXXXXXSKVLAKGLGLS---KAYVGQKGSFTVDCSKAGNNMLLV 2576
            D                      KV   G GL    +A V Q  +FTVDCS+AG   L V
Sbjct: 1442 D--------------------PGKVKCSGPGLGAGVRARVPQ--TFTVDCSQAGRAPLQV 1479

Query: 2577 GVHGPRTPCEEILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLV 2738
             V GP    E + V+  G   ++V Y     G YT+ VK+ D+ +P SP+++ V
Sbjct: 1480 AVLGPTGVAEPVEVRDNGDGTHTVHYTPATDGPYTVAVKYADQEVPRSPFKIKV 1533



 Score =  296 bits (757), Expect = 1e-79
 Identities = 246/902 (27%), Positives = 382/902 (42%), Gaps = 57/902 (6%)
 Frame = +3

Query: 204  GEITGEVRMPSGKVAQPAITDN--KDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFY 377
            GE+   +  P G   +  +  N  KD T  V Y P  AGLH++ + +   +I  SP +  
Sbjct: 308  GEVLVYIEDPEGHTEEAKVVPNNDKDRTYAVSYVPKVAGLHKVTVLFAGQNIERSPFEVN 367

Query: 378  VDYV--NCGHVTAYGPGLSH--GVVNKPAVFTVNTKDAGEGGLSLAIEGPS----KAEIS 533
            V     +   V+A GPGL     V NKP  F + T  AG G +++ I  P       E++
Sbjct: 368  VGMALGDANKVSARGPGLEPVGNVANKPTYFDIYTAGAGTGDVAVVIVDPQGRRDTVEVA 427

Query: 534  CTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARVT----------GDDSMRMS 683
              D  D T   +Y P + G +++ V +    I  SPF   V+              ++  
Sbjct: 428  LEDKGDSTFRCTYRPAMEGPHTVHVAFAGAPITRSPFPVHVSEACNPNACRASGRGLQPK 487

Query: 684  HLKVGSAADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLV 863
             ++V   AD  +         L  TV  P G EEP  ++   +G     + P   G+++V
Sbjct: 488  GVRVKEVADFKVFTKGAGSGELKVTVKGPKGTEEPVKVREAGDGVFECEYYPVVPGKYVV 547

Query: 864  HVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEGHTFEPAEFIIDTRDAGYGGLS 1043
             +   G  +  SP  V +S        +VR  G GL  G   + A+F+++      G L 
Sbjct: 548  TITWGGYAIPRSPFEVQVSPE--AGVQKVRAWGPGLETGQVGKSADFVVEAIGTEVGTLG 605

Query: 1044 LSIEGPSKVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPF----------- 1190
             SIEGPS+  I  +D  DG+C V Y PTEPG Y +++   D+ +  SPF           
Sbjct: 606  FSIEGPSQAKIECDDKGDGSCDVRYWPTEPGEYAVHVICDDEDIRDSPFIAHILPAPPDC 665

Query: 1191 ---SVKVTGEGRVKESITRRQRAPSVANVGSHCDLSLKIPEISIQDMTAQVTSPSGKSHE 1361
                VK  G G            P+   V    + ++        D+        G   +
Sbjct: 666  FPDKVKAFGPG----------LEPTGCIVDKPAEFTIDARAAGKGDLKLYAQDADGCPID 715

Query: 1362 AEIVEGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAH--KVRAGG 1535
             +++   + T+   +VP +   HT+ + + G +VP SPF+  VG     G+H  +V+  G
Sbjct: 716  IKVIPNGDGTFRCSYVPTKPIKHTIIISWGGVNVPKSPFRVNVGE----GSHPERVKVYG 771

Query: 1536 PGLERA--EAGVPAEFSIWTREAGAGGLAIAVE------GPSKAEISFEDRK--DGSCGV 1685
            PG+E+   +A  P  F++   EAG G ++I ++      GP++A+I F+  K  + +  V
Sbjct: 772  PGVEKTGLKANEPTYFTVDCSEAGQGDVSIGIKCAPGVVGPAEADIDFDIIKNDNDTFTV 831

Query: 1686 AYVVQEPGDYEVSVKFNEEHIPDSPFVVPVASPSGDARRLTVS--SLQESGLKVNQPASF 1859
             Y     G Y + V F  + IP SPF + V  PS DA ++      L  +G++V +P  F
Sbjct: 832  KYTPPGAGRYTIMVLFANQEIPASPFHIKV-DPSHDASKVKAEGPGLNRTGVEVGKPTHF 890

Query: 1860 AVSLNGA-KGAIDAKV--HSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTH 2030
             V   GA K  +D +    +    + +  + +     Y V++   + G   + V + G  
Sbjct: 891  TVLTKGAGKAKLDVQFAGTAKGEVVRDFEIIDNHDYSYTVKYTAVQQGNMAVTVTYGGDP 950

Query: 2031 IPGSPFKIRVGEPGHGGDPGLVSAYGAGLEGGVTGSPAEFIVNTSNAGA-GALSVTIDGP 2207
            +P SPF + V  P    D   +   G   +  V G    F VNT  AG  G L V +  P
Sbjct: 951  VPKSPFVVNVAPP---LDLSKIKVQGLNSKVAV-GQEQAFSVNTRGAGGQGQLDVRMTSP 1006

Query: 2208 SKVKMDCQECP----EGYRVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNH 2375
            S+  + C+  P    E   V Y P   G Y + I Y G + + GSPF             
Sbjct: 1007 SRRPIPCKLEPGGGAEAQAVRYMPPEEGPYKVDITYDG-HPVPGSPFAVE---------- 1055

Query: 2376 SLHETSSVFVDSLTKTXXXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKA 2555
                                            SKV A G GL    VG    F++D   A
Sbjct: 1056 -------------------------GVLPPDPSKVCAYGPGLKGGLVGTPAPFSIDTKGA 1090

Query: 2556 GNNMLLVGVHGPRTPCE-EILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRV 2732
            G   L + V G   PCE +I  +  G    +VSYL  + GEYT+ + + + HIPGSP++ 
Sbjct: 1091 GTGGLGLTVEG---PCEAKIECQDNGDGSCAVSYLPTEPGEYTINILFAEAHIPGSPFKA 1147

Query: 2733 LV 2738
             +
Sbjct: 1148 TI 1149



 Score =  273 bits (699), Expect = 5e-73
 Identities = 173/478 (36%), Positives = 242/478 (50%), Gaps = 50/478 (10%)
 Frame = +3

Query: 207  EITGEVRMPSGKVAQPAITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFYVDY 386
            ++T +V  PSGKV    I + +D   +VR+ P E G H + ++Y   H+PGSP QF V  
Sbjct: 2216 DMTAQVTSPSGKVEAAEIVEGEDSAYSVRFVPQEMGPHTVAVKYRGQHVPGSPFQFTVGP 2275

Query: 387  VNCG---HVTAYGPGLSHGVVNKPAVFTVNTKDAGEGGLSLAIEGPSKAEISCTDNQDGT 557
            +  G    V A G GL  GV   PA F++ T++AG GGLS+A+EGPSKAEI+  D +DG+
Sbjct: 2276 LGEGGAHKVRAGGTGLERGVAGVPAEFSIWTREAGAGGLSIAVEGPSKAEIAFEDRKDGS 2335

Query: 558  CSVSYLPVLPGDYSILVKYNEQHIPGSPFTARVTG--DDSMRMS-------HLKVGSAAD 710
            C VSY+   PGDY + +K+N++HIP SPF   V    DD+ R++        LKV   A 
Sbjct: 2336 CGVSYVVQEPGDYEVSIKFNDEHIPDSPFVVPVASLSDDARRLTVTSLQETGLKVNQPAS 2395

Query: 711  IPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNGQHV 890
              + ++     ++ A V  PSG  E C +  L +    I F+P E G H + VK NG H+
Sbjct: 2396 FAVQLNGAR-GVIDARVHTPSGAVEECYVSELDSDKHTIRFIPHENGVHSIDVKFNGAHI 2454

Query: 891  ASSPIPVVIS-QSEIGDASRVRVSGRGLHEGHTFEPAEFIIDTRDAGYGGLSLSIEGPSK 1067
              SP  + +  QS+ GD   V   G GL  G T   +EFI++T +AG G LS++I+GPSK
Sbjct: 2455 PGSPFKIRVGEQSQAGDPGLVSAYGPGLEGGTTGVSSEFIVNTLNAGSGALSVTIDGPSK 2514

Query: 1068 VDINTEDLEDGTCRVTYCPTEPGNYIINIKF-ADQHVPGSPFSVKVTG------------ 1208
            V ++  +  +G   VTY P  PGNY+I IK+   QH+ GSPF  KVTG            
Sbjct: 2515 VQLDCRECPEGHV-VTYTPMAPGNYLIAIKYGGPQHIVGSPFKAKVTGPRLSGGHSLHET 2573

Query: 1209 -----EGRVKESITRRQ-----------------RAP--SVANVGSHCDLSLKIPEISIQ 1316
                 E   K S +R                   R P  S A VG     ++   +    
Sbjct: 2574 STVLVETVTKSSSSRGSSYSSIPKFSSDASKVVTRGPGLSQAFVGQKNSFTVDCSKAGTN 2633

Query: 1317 DMTAQVTSPSGKSHEAEIVEGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTV 1490
             M   V  P     E  +    N  Y + +   E G + + VK+  + VPGSPF+  V
Sbjct: 2634 MMMVGVHGPKTPCEEVYVKHMGNRVYNVTYTVKEKGDYILIVKWGDESVPGSPFKVKV 2691



 Score =  239 bits (609), Expect = 1e-62
 Identities = 239/840 (28%), Positives = 369/840 (43%), Gaps = 47/840 (5%)
 Frame = +3

Query: 354  PGSPLQFYVDYVNCGHVTAYGPGLSH--GVVNKPAVFTVNTKDAGEGGLSLAIEGP---- 515
            PG+P++     +N     AYGPG+      V +PA FTV T DAG G + + IE P    
Sbjct: 264  PGAPVRS--KQLNPKKAIAYGPGIEPQGNTVLQPAHFTVQTVDAGVGEVLVYIEDPEGHT 321

Query: 516  SKAEISCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARV---TGDD---SMR 677
             +A++   +++D T +VSY+P + G + + V +  Q+I  SPF   V    GD    S R
Sbjct: 322  EEAKVVPNNDKDRTYAVSYVPKVAGLHKVTVLFAGQNIERSPFEVNVGMALGDANKVSAR 381

Query: 678  MSHLK-VGSAADIP----INISETDLSLLTATVVPPSGREE--PCLLKRLRNGHVGISFV 836
               L+ VG+ A+ P    I  +      +   +V P GR +     L+   +     ++ 
Sbjct: 382  GPGLEPVGNVANKPTYFDIYTAGAGTGDVAVVIVDPQGRRDTVEVALEDKGDSTFRCTYR 441

Query: 837  PKETGEHLVHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEG--HTFEPAEFII 1010
            P   G H VHV   G  +  SP PV +  SE  + +  R SGRGL        E A+F +
Sbjct: 442  PAMEGPHTVHVAFAGAPITRSPFPVHV--SEACNPNACRASGRGLQPKGVRVKEVADFKV 499

Query: 1011 DTRDAGYGGLSLSIEGPSKVD--INTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGS 1184
             T+ AG G L ++++GP   +  +   +  DG     Y P  PG Y++ I +    +P S
Sbjct: 500  FTKGAGSGELKVTVKGPKGTEEPVKVREAGDGVFECEYYPVVPGKYVVTITWGGYAIPRS 559

Query: 1185 PFSVKVTGEGRVKESITRRQRAPSV--ANVGSHCDLSLKIPEISIQDMTAQVTSPSGKSH 1358
            PF V+V+ E  V++    R   P +    VG   D  ++     +  +   +  PS    
Sbjct: 560  PFEVQVSPEAGVQKV---RAWGPGLETGQVGKSADFVVEAIGTEVGTLGFSIEGPSQAKI 616

Query: 1359 EAEIVEGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPL-GEGGAHKVRAGG 1535
            E +  +  + +  +R+ P E G + V V    + +  SPF   + P   +    KV+A G
Sbjct: 617  ECD--DKGDGSCDVRYWPTEPGEYAVHVICDDEDIRDSPFIAHILPAPPDCFPDKVKAFG 674

Query: 1536 PGLERAEAGV--PAEFSIWTREAGAGGLAIAVEGPSKAEISFE--DRKDGSCGVAYVVQE 1703
            PGLE     V  PAEF+I  R AG G L +  +      I  +     DG+   +YV  +
Sbjct: 675  PGLEPTGCIVDKPAEFTIDARAAGKGDLKLYAQDADGCPIDIKVIPNGDGTFRCSYVPTK 734

Query: 1704 PGDYEVSVKFNEEHIPDSPFVVPVASPSGDAR-RLTVSSLQESGLKVNQPASFAVSLNGA 1880
            P  + + + +   ++P SPF V V   S   R ++    ++++GLK N+P  F V  + A
Sbjct: 735  PIKHTIIISWGGVNVPKSPFRVNVGEGSHPERVKVYGPGVEKTGLKANEPTYFTVDCSEA 794

Query: 1881 -KGAIDAKVH------SPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPG 2039
             +G +   +        P+ A  +  + + D D + V++ P   G Y I V F    IP 
Sbjct: 795  GQGDVSIGIKCAPGVVGPAEADIDFDIIKNDNDTFTVKYTPPGAGRYTIMVLFANQEIPA 854

Query: 2040 SPFKIRVGEPGHGGDPGLVSAYGAGLE--GGVTGSPAEFIVNTSNAGAGALSVTIDGPSK 2213
            SPF I+V +P H  D   V A G GL   G   G P  F V T  AG   L V   G +K
Sbjct: 855  SPFHIKV-DPSH--DASKVKAEGPGLNRTGVEVGKPTHFTVLTKGAGKAKLDVQFAGTAK 911

Query: 2214 --VKMDCQECPE---GYRVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHS 2378
              V  D +        Y V YT +  G+  +++ YGG   +  SPF   V          
Sbjct: 912  GEVVRDFEIIDNHDYSYTVKYTAVQQGNMAVTVTYGGD-PVPKSPFVVNVA--------- 961

Query: 2379 LHETSSVFVDSLTKTXXXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKA- 2555
                                           SK+  +GL  SK  VGQ+ +F+V+   A 
Sbjct: 962  --------------------------PPLDLSKIKVQGLN-SKVAVGQEQAFSVNTRGAG 994

Query: 2556 GNNMLLVGVHGP-RTPCEEILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRV 2732
            G   L V +  P R P    L    G+   +V Y+  ++G Y + + +    +PGSP+ V
Sbjct: 995  GQGQLDVRMTSPSRRPIPCKLEPGGGAEAQAVRYMPPEEGPYKVDITYDGHPVPGSPFAV 1054



 Score =  131 bits (329), Expect = 4e-30
 Identities = 91/313 (29%), Positives = 140/313 (44%), Gaps = 53/313 (16%)
 Frame = +3

Query: 138  VNGLDVTSLR---PFDLVIPFTIKKGEITGEVRMPSGKVAQPAITDNKDGTVTVRYAPSE 308
            V  L  T L+   P    +     +G I   V  PSG V +  +++      T+R+ P E
Sbjct: 2380 VTSLQETGLKVNQPASFAVQLNGARGVIDARVHTPSGAVEECYVSELDSDKHTIRFIPHE 2439

Query: 309  AGLHEMDIRYDNMHIPGSPLQFYVDYVNC----GHVTAYGPGLSHGVVNKPAVFTVNTKD 476
             G+H +D++++  HIPGSP +  V   +     G V+AYGPGL  G     + F VNT +
Sbjct: 2440 NGVHSIDVKFNGAHIPGSPFKIRVGEQSQAGDPGLVSAYGPGLEGGTTGVSSEFIVNTLN 2499

Query: 477  AGEGGLSLAIEGPSKAEISCTDNQDGTCSVSYLPVLPGDYSILVKY-NEQHIPGSPFTAR 653
            AG G LS+ I+GPSK ++ C +  +G   V+Y P+ PG+Y I +KY   QHI GSPF A+
Sbjct: 2500 AGSGALSVTIDGPSKVQLDCRECPEGHV-VTYTPMAPGNYLIAIKYGGPQHIVGSPFKAK 2558

Query: 654  VTG----------------------DDSMR-----------------------MSHLKVG 698
            VTG                        S R                       +S   VG
Sbjct: 2559 VTGPRLSGGHSLHETSTVLVETVTKSSSSRGSSYSSIPKFSSDASKVVTRGPGLSQAFVG 2618

Query: 699  SAADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKN 878
                  ++ S+   +++   V  P    E   +K + N    +++  KE G++++ VK  
Sbjct: 2619 QKNSFTVDCSKAGTNMMMVGVHGPKTPCEEVYVKHMGNRVYNVTYTVKEKGDYILIVKWG 2678

Query: 879  GQHVASSPIPVVI 917
             + V  SP  V +
Sbjct: 2679 DESVPGSPFKVKV 2691


>ref|NP_001449.3| filamin-C isoform a [Homo sapiens].
          Length = 2725

 Score =  797 bits (2058), Expect = 0.0
 Identities = 439/856 (51%), Positives = 557/856 (65%), Gaps = 24/856 (2%)
 Frame = +3

Query: 246  AQPAITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFYVDYVNCGHVTAYGPGL 425
            A+    DNKDGT TV Y P+  G + + +R+D+ HIPGSP    +   +    +    G 
Sbjct: 1902 AEITCKDNKDGTCTVSYLPTAPGDYSIIVRFDDKHIPGSPFTAKITGDDSMRTSQLNVGT 1961

Query: 426  SHGVVNKPAVFTVNTKDAGEGGLSLAIEGPSKAEISCTDNQ--DGTCSVSYLPVLPGDYS 599
            S  V  K     +   D  +  L+ +I  PS  E  C   +  +    +S+ P   G++ 
Sbjct: 1962 STDVSLK-----ITESDLSQ--LTASIRAPSGNEEPCLLKRLPNRHIGISFTPKEVGEHV 2014

Query: 600  ILVKYNEQHIPGSPFTARVTGDDSMRMSHLKVGS----------AADIPINISETDLSLL 749
            + V+ + +H+  SPF   V   +    S ++V             A+  ++        L
Sbjct: 2015 VSVRKSGKHVTNSPFKILVGPSEIGDASKVRVWGKGLSEGHTFQVAEFIVDTRNAGYGGL 2074

Query: 750  TATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNGQHVASSPIPVVISQSE 929
              ++  PS  +  C  + + +G   +++ P E G +++++K   +HV  SP  V ++   
Sbjct: 2075 GLSIEGPSKVDINC--EDMEDGTCKVTYCPTEPGTYIINIKFADKHVPGSPFTVKVTGE- 2131

Query: 930  IGDASRVRVSGRGLHEGHTFEPAEFIIDTR---DAGYGGLSLSIEGPSKVDINTEDLEDG 1100
                 R++ S     +  +        D        +  +  + E  ++    +      
Sbjct: 2132 ----GRMKESITRRRQAPSIATIGSTCDLNLKIPGNWFQMVSAQERLTRTFTRSSHTYTR 2187

Query: 1101 TCRVTYCPTEPGNYIINIKFADQ-HVPGSPFSVKVTGEGRVKE------SITRRQRAPSV 1259
            T R     T  G     ++  +   V G PF   V G+   +E      SITR+Q     
Sbjct: 2188 TERTEISKTRGGETKREVRVEESTQVGGDPFPA-VFGDFLGRERLGSFGSITRQQEG--- 2243

Query: 1260 ANVGSHCDLSLKIPEISIQDMTAQVTSPSGKSHEAEIVEGENHTYCIRFVPAEMGMHTVS 1439
                          E S QDMTAQVTSPSGK   AEIVEGE+  Y +RFVP EMG HTV+
Sbjct: 2244 --------------EASSQDMTAQVTSPSGKVEAAEIVEGEDSAYSVRFVPQEMGPHTVA 2289

Query: 1440 VKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLERAEAGVPAEFSIWTREAGAGGLAI 1619
            VKY+GQHVPGSPFQFTVGPLGEGGAHKVRAGG GLER  AGVPAEFSIWTREAGAGGL+I
Sbjct: 2290 VKYRGQHVPGSPFQFTVGPLGEGGAHKVRAGGTGLERGVAGVPAEFSIWTREAGAGGLSI 2349

Query: 1620 AVEGPSKAEISFEDRKDGSCGVAYVVQEPGDYEVSVKFNEEHIPDSPFVVPVASPSGDAR 1799
            AVEGPSKAEI+FEDRKDGSCGV+YVVQEPGDYEVS+KFN+EHIPDSPFVVPVAS S DAR
Sbjct: 2350 AVEGPSKAEIAFEDRKDGSCGVSYVVQEPGDYEVSIKFNDEHIPDSPFVVPVASLSDDAR 2409

Query: 1800 RLTVSSLQESGLKVNQPASFAVSLNGAKGAIDAKVHSPSGALEECYVTEIDQDKYAVRFI 1979
            RLTV+SLQE+GLKVNQPASFAV LNGA+G IDA+VH+PSGA+EECYV+E+D DK+ +RFI
Sbjct: 2410 RLTVTSLQETGLKVNQPASFAVQLNGARGVIDARVHTPSGAVEECYVSELDSDKHTIRFI 2469

Query: 1980 PRENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPGLVSAYGAGLEGGVTGSPAEFIVN 2159
            P ENGV+ IDVKFNG HIPGSPFKIRVGE    GDPGLVSAYG GLEGG TG  +EFIVN
Sbjct: 2470 PHENGVHSIDVKFNGAHIPGSPFKIRVGEQSQAGDPGLVSAYGPGLEGGTTGVSSEFIVN 2529

Query: 2160 TSNAGAGALSVTIDGPSKVKMDCQECPEGYRVTYTPMAPGSYLISIKYGGPYHIGGSPFK 2339
            T NAG+GALSVTIDGPSKV++DC+ECPEG+ VTYTPMAPG+YLI+IKYGGP HI GSPFK
Sbjct: 2530 TLNAGSGALSVTIDGPSKVQLDCRECPEGHVVTYTPMAPGNYLIAIKYGGPQHIVGSPFK 2589

Query: 2340 ARVTGHRLVSNHSLHETSSVFVDSLTK--TXXXXXXXXXXXXXXXXSKVLAKGLGLSKAY 2513
            A+VTG RL   HSLHETS+V V+++TK  +                SKV+ +G GLS+A+
Sbjct: 2590 AKVTGPRLSGGHSLHETSTVLVETVTKSSSSRGSSYSSIPKFSSDASKVVTRGPGLSQAF 2649

Query: 2514 VGQKGSFTVDCSKAGNNMLLVGVHGPRTPCEEILVKHVGSRLYSVSYLLKDKGEYTLVVK 2693
            VGQK SFTVDCSKAG NM++VGVHGP+TPCEE+ VKH+G+R+Y+V+Y +K+KG+Y L+VK
Sbjct: 2650 VGQKNSFTVDCSKAGTNMMMVGVHGPKTPCEEVYVKHMGNRVYNVTYTVKEKGDYILIVK 2709

Query: 2694 WGDEHIPGSPYRVLVP 2741
            WGDE +PGSP++V VP
Sbjct: 2710 WGDESVPGSPFKVKVP 2725



 Score =  702 bits (1811), Expect = 0.0
 Identities = 407/888 (45%), Positives = 527/888 (59%), Gaps = 12/888 (1%)
 Frame = +3

Query: 111  WAPERPLVGVNGLDVTSLRPFDLVIPFTIKKGEITGEVRMPSGKVAQPAITDNKDGTVTV 290
            WA E P+V V  ++ + LRPF+LVIPF ++KGE+TGEVRMPSGK A+P ITDNKDGT+TV
Sbjct: 1766 WATEEPVVPVEPME-SMLRPFNLVIPFAVQKGELTGEVRMPSGKTARPNITDNKDGTITV 1824

Query: 291  RYAPSEAGLHEMDIRYDNMHIPGSPLQFYVDYVNCGHVTAYGPGLSHGVVNKPAVFTVNT 470
            RYAP+E GLH+M I+YD  HIPGSPLQFYVD +N  HV+AYGPGLSHG+VNKPA FT+ T
Sbjct: 1825 RYAPTEKGLHQMGIKYDGNHIPGSPLQFYVDAINSRHVSAYGPGLSHGMVNKPATFTIVT 1884

Query: 471  KDAGEGGLSLAIEGPSKAEISCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTA 650
            KDAGEGGLSLA+EGPSKAEI+C DN+DGTC+VSYLP  PGDYSI+V+++++HIPGSPFTA
Sbjct: 1885 KDAGEGGLSLAVEGPSKAEITCKDNKDGTCTVSYLPTAPGDYSIIVRFDDKHIPGSPFTA 1944

Query: 651  RVTGDDSMRMSHLKVGSAADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGIS 830
            ++TGDDSMR S L VG++ D+ + I+E+DLS LTA++  PSG EEPCLLKRL N H+GIS
Sbjct: 1945 KITGDDSMRTSQLNVGTSTDVSLKITESDLSQLTASIRAPSGNEEPCLLKRLPNRHIGIS 2004

Query: 831  FVPKETGEHLVHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEGHTFEPAEFII 1010
            F PKE GEH+V V+K+G+HV +SP  +++  SEIGDAS+VRV G+GL EGHTF+ AEFI+
Sbjct: 2005 FTPKEVGEHVVSVRKSGKHVTNSPFKILVGPSEIGDASKVRVWGKGLSEGHTFQVAEFIV 2064

Query: 1011 DTRDAGYGGLSLSIEGPSKVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPF 1190
            DTR+AGYGGL LSIEGPSKVDIN ED+EDGTC+VTYCPTEPG YIINIKFAD+HVPGSPF
Sbjct: 2065 DTRNAGYGGLGLSIEGPSKVDINCEDMEDGTCKVTYCPTEPGTYIINIKFADKHVPGSPF 2124

Query: 1191 SVKVTGEGRVKESITRRQRAPSVANVGSHCDLSLKIPEISIQDMTAQVTSPSGKSHEAEI 1370
            +VKVTGEGR+KESITRR++APS+A +GS CDL+LKIP    Q ++AQ       +  +  
Sbjct: 2125 TVKVTGEGRMKESITRRRQAPSIATIGSTCDLNLKIPGNWFQMVSAQERLTRTFTRSSHT 2184

Query: 1371 VEGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPG-LE 1547
                  T   +    E     V V+   Q V G PF    G        + R G  G + 
Sbjct: 2185 YTRTERTEISKTRGGET-KREVRVEESTQ-VGGDPFPAVFGDF----LGRERLGSFGSIT 2238

Query: 1548 RAEAGVPAEFSIWTREAGAGGLAIAVEGPS-KAEIS-FEDRKDGSCGVAYVVQEPGDYEV 1721
            R + G          EA +  +   V  PS K E +   + +D +  V +V QE G + V
Sbjct: 2239 RQQEG----------EASSQDMTAQVTSPSGKVEAAEIVEGEDSAYSVRFVPQEMGPHTV 2288

Query: 1722 SVKFNEEHIPDSPFVVPVAS-PSGDARRLTVSSLQESGLKVNQPASFAV-SLNGAKGAID 1895
            +VK+  +H+P SPF   V     G A ++              PA F++ +     G + 
Sbjct: 2289 AVKYRGQHVPGSPFQFTVGPLGEGGAHKVRAGGTGLERGVAGVPAEFSIWTREAGAGGLS 2348

Query: 1896 AKVHSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGH 2075
              V  PS A  E    +       V ++ +E G Y + +KFN  HIP SPF + V     
Sbjct: 2349 IAVEGPSKA--EIAFEDRKDGSCGVSYVVQEPGDYEVSIKFNDEHIPDSPFVVPVA--SL 2404

Query: 2076 GGDPGLVSAYGAGLEGGVTGSPAEFIVNTSNAGAGALSVTIDGPSKVKMDC---QECPEG 2246
              D   ++       G     PA F V   N   G +   +  PS    +C   +   + 
Sbjct: 2405 SDDARRLTVTSLQETGLKVNQPASFAVQL-NGARGVIDARVHTPSGAVEECYVSELDSDK 2463

Query: 2247 YRVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSVFVDSLTKTX 2426
            + + + P   G + I +K+ G  HI GSPFK RV       +  L               
Sbjct: 2464 HTIRFIPHENGVHSIDVKFNGA-HIPGSPFKIRVGEQSQAGDPGL--------------- 2507

Query: 2427 XXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKAGNNMLLVGVHGP---RT 2597
                             V A G GL     G    F V+   AG+  L V + GP   + 
Sbjct: 2508 -----------------VSAYGPGLEGGTTGVSSEFIVNTLNAGSGALSVTIDGPSKVQL 2550

Query: 2598 PCEEILVKHVGSRLYSVSYLLKDKGEYTLVVKW-GDEHIPGSPYRVLV 2738
             C E    HV      V+Y     G Y + +K+ G +HI GSP++  V
Sbjct: 2551 DCRECPEGHV------VTYTPMAPGNYLIAIKYGGPQHIVGSPFKAKV 2592



 Score =  359 bits (922), Expect = 7e-99
 Identities = 276/885 (31%), Positives = 417/885 (47%), Gaps = 40/885 (4%)
 Frame = +3

Query: 204  GEITGEVRMPSGK--VAQPAITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFY 377
            G++   +  P G+    + A+ D  D T    Y P+  G H + + +    I  SP   +
Sbjct: 408  GDVAVVIVDPQGRRDTVEVALEDKGDSTFRCTYRPAMEGPHTVHVAFAGAPITRSPFPVH 467

Query: 378  V-DYVNCGHVTAYGPGLS-HGV-VNKPAVFTVNTKDAGEGGLSLAIEGPSKAE--ISCTD 542
            V +  N     A G GL   GV V + A F V TK AG G L + ++GP   E  +   +
Sbjct: 468  VSEACNPNACRASGRGLQPKGVRVKEVADFKVFTKGAGSGELKVTVKGPKGTEEPVKVRE 527

Query: 543  NQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARVTGDDSMRMSHL--------KVG 698
              DG     Y PV+PG Y + + +    IP SPF  +V+ +  ++            +VG
Sbjct: 528  AGDGVFECEYYPVVPGKYVVTITWGGYAIPRSPFEVQVSPEAGVQKVRAWGPGLETGQVG 587

Query: 699  SAADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKN 878
             +AD  +    T++  L  ++  PS  +  C  K   +G   + + P E GE+ VHV  +
Sbjct: 588  KSADFVVEAIGTEVGTLGFSIEGPSQAKIECDDKG--DGSCDVRYWPTEPGEYAVHVICD 645

Query: 879  GQHVASSP-IPVVISQSEIGDASRVRVSGRGLHEGHTF--EPAEFIIDTRDAGYGGLSLS 1049
             + +  SP I  ++         +V+  G GL        +PAEF ID R AG G L L 
Sbjct: 646  DEDIRDSPFIAHILPAPPDCFPDKVKAFGPGLEPTGCIVDKPAEFTIDARAAGKGDLKLY 705

Query: 1050 IEGPS--KVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTGEGRVK 1223
             +      +DI      DGT R +Y PT+P  + I I +   +VP SPF V V GEG   
Sbjct: 706  AQDADGCPIDIKVIPNGDGTFRCSYVPTKPIKHTIIISWGGVNVPKSPFRVNV-GEGSHP 764

Query: 1224 ESITRRQRAPSVANVGSHCD----LSLKIPEISIQDMTAQ------VTSPSGKSHEAEIV 1373
            E +  +   P V   G   +     ++   E    D++        V  P+    + +I+
Sbjct: 765  ERV--KVYGPGVEKTGLKANEPTYFTVDCSEAGQGDVSIGIKCAPGVVGPAEADIDFDII 822

Query: 1374 EGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLERA 1553
            + +N T+ +++ P   G +T+ V +  Q +P SPF   V P  +  A KV+A GPGL R 
Sbjct: 823  KNDNDTFTVKYTPPGAGRYTIMVLFANQEIPASPFHIKVDPSHD--ASKVKAEGPGLNRT 880

Query: 1554 --EAGVPAEFSIWTREAGAGGLAIAVEGPSKAEI--SFE--DRKDGSCGVAYVVQEPGDY 1715
              E G P  F++ T+ AG   L +   G +K E+   FE  D  D S  V Y   + G+ 
Sbjct: 881  GVEVGKPTHFTVLTKGAGKAKLDVQFAGTAKGEVVRDFEIIDNHDYSYTVKYTAVQQGNM 940

Query: 1716 EVSVKFNEEHIPDSPFVVPVASPSGDARRLTVSSLQESGLKVNQPASFAVSLNGA--KGA 1889
             V+V +  + +P SPFVV VA P  D  ++ V  L  S + V Q  +F+V+  GA  +G 
Sbjct: 941  AVTVTYGGDPVPKSPFVVNVAPPL-DLSKIKVQGLN-SKVAVGQEQAFSVNTRGAGGQGQ 998

Query: 1890 IDAKVHSPSGALEECYVTEID-QDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGE 2066
            +D ++ SPS     C +      +  AVR++P E G Y +D+ ++G  +PGSPF +    
Sbjct: 999  LDVRMTSPSRRPIPCKLEPGGGAEAQAVRYMPPEEGPYKVDITYDGHPVPGSPFAVEGVL 1058

Query: 2067 PGHGGDPGLVSAYGAGLEGGVTGSPAEFIVNTSNAGAGALSVTIDGPSKVKMDCQECPEG 2246
            P    DP  V AYG GL+GG+ G+PA F ++T  AG G L +T++GP + K++CQ+  +G
Sbjct: 1059 PP---DPSKVCAYGPGLKGGLVGTPAPFSIDTKGAGTGGLGLTVEGPCEAKIECQDNGDG 1115

Query: 2247 Y-RVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSVFVDSLTKT 2423
               V+Y P  PG Y I+I +    HI GSPFKA +                VF       
Sbjct: 1116 SCAVSYLPTEPGEYTINILFAEA-HIPGSPFKATI--------------RPVF------- 1153

Query: 2424 XXXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKAGNNMLLVGVHGPRTPC 2603
                            SKV A G GL +  VG+  +FTVDCS+AG   L + +       
Sbjct: 1154 --------------DPSKVRASGPGLERGKVGEAATFTVDCSEAGEAELTIEILSDAGVK 1199

Query: 2604 EEILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLV 2738
             E+L+ +     Y ++Y     G YT+ +K+G   +P  P RV V
Sbjct: 1200 AEVLIHNNADGTYHITYSPAFPGTYTITIKYGGHPVPKFPTRVHV 1244



 Score =  324 bits (831), Expect = 3e-88
 Identities = 253/906 (27%), Positives = 407/906 (44%), Gaps = 60/906 (6%)
 Frame = +3

Query: 201  KGEITGEVRMPSGKVAQPAITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFYV 380
            + E+T E+   +G  A+  I +N DGT  + Y+P+  G + + I+Y    +P  P + +V
Sbjct: 1185 EAELTIEILSDAGVKAEVLIHNNADGTYHITYSPAFPGTYTITIKYGGHPVPKFPTRVHV 1244

Query: 381  D-YVNCGHVTAYGPGLS-HGVVNKPAV-FTVNTKD---AGEGGLSLAIEGPS--KAEISC 536
               V+   V   GPG+  HGV+ +    FTV+ +     G   ++  +  PS  K +   
Sbjct: 1245 QPAVDTSGVKVSGPGVEPHGVLREVTTEFTVDARSLTATGGNHVTARVLNPSGAKTDTYV 1304

Query: 537  TDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARVT-GDDSMRMSHLKVG----- 698
            TDN DGT  V Y     G + + V Y+E  +P SPF   VT G D  R+     G     
Sbjct: 1305 TDNGDGTYRVQYTAYEEGVHLVEVLYDEVAVPKSPFRVGVTEGCDPTRVRAFGPGLEGGL 1364

Query: 699  --SAADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVK 872
               A    +         L   +  PS  +  C  K  ++G   + ++P   G++ V++ 
Sbjct: 1365 VNKANRFTVETRGAGTGGLGLAIEGPSEAKMSC--KDNKDGSCTVEYIPFTPGDYDVNIT 1422

Query: 873  KNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEG-HTFEPAEFIIDTRDAGYGGLSLS 1049
              G+ +  SP  V +   ++ D  +V+ SG GL  G     P  F +D   AG   L ++
Sbjct: 1423 FGGRPIPGSPFRVPVK--DVVDPGKVKCSGPGLGAGVRARVPQTFTVDCSQAGRAPLQVA 1480

Query: 1050 IEGPSKV--DINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTGEGRVK 1223
            + GP+ V   +   D  DGT  V Y P   G Y + +K+ADQ VP SPF +KV       
Sbjct: 1481 VLGPTGVAEPVEVRDNGDGTHTVHYTPATDGPYTVAVKYADQEVPRSPFKIKVLP---AH 1537

Query: 1224 ESITRRQRAPSVANVGSHCDLSLKIPEISIQD-----MTAQVTSPSGKSHEAEIVEGENH 1388
            ++   R   P +   G    L ++   I  +D     +T Q+  P GK  +A I +  + 
Sbjct: 1538 DASKVRASGPGLNASGIPASLPVEFT-IDARDAGEGLLTVQILDPEGKPKKANIRDNGDG 1596

Query: 1389 TYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGG--AHKVRAGGPGL-----E 1547
            TY + ++P   G +T+++KY G  +P SPF+    P G+       V  GG GL      
Sbjct: 1597 TYTVSYLPDMSGRYTITIKYGGDEIPYSPFRIHALPTGDASKCLVTVSIGGHGLGACLGP 1656

Query: 1548 RAEAGVPAEFSIWTREAGAGGLAIAVEGPSKAEISFE--DRKDGSCGVAYVVQEPGDYEV 1721
            R + G     ++  + AG G +   V  P  AE+  +  +  DG+  + Y   EPG Y +
Sbjct: 1657 RIQIGQETVITVDAKAAGEGKVTCTVSTPDGAELDVDVVENHDGTFDIYYTAPEPGKYVI 1716

Query: 1722 SVKFNEEHIPDSPFVV--------------------PVASPSGDARRLTVSSLQESGLKV 1841
            +++F  EHIP+SPF V                    P A P   AR  T  + +E  + V
Sbjct: 1717 TIRFGGEHIPNSPFHVLACDPLPHEEEPSEVPQLRQPYAPPRPGARP-THWATEEPVVPV 1775

Query: 1842 N------QPASFAVSLNGAKGAIDAKVHSPSGALEECYVTEIDQDKYAVRFIPRENGVYL 2003
                   +P +  +     KG +  +V  PSG      +T+       VR+ P E G++ 
Sbjct: 1776 EPMESMLRPFNLVIPFAVQKGELTGEVRMPSGKTARPNITDNKDGTITVRYAPTEKGLHQ 1835

Query: 2004 IDVKFNGTHIPGSPFKIRVGEPGHGGDPGLVSAYGAGLEGGVTGSPAEFIVNTSNAGAGA 2183
            + +K++G HIPGSP +  V       +   VSAYG GL  G+   PA F + T +AG G 
Sbjct: 1836 MGIKYDGNHIPGSPLQFYV----DAINSRHVSAYGPGLSHGMVNKPATFTIVTKDAGEGG 1891

Query: 2184 LSVTIDGPSKVKMDCQECPEG-YRVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHR 2360
            LS+ ++GPSK ++ C++  +G   V+Y P APG Y I +++    HI GSPF A++TG  
Sbjct: 1892 LSLAVEGPSKAEITCKDNKDGTCTVSYLPTAPGDYSIIVRFDDK-HIPGSPFTAKITG-- 1948

Query: 2361 LVSNHSLHETSSVFVDSLTKTXXXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTV 2540
                           D   +T                          S+  VG     ++
Sbjct: 1949 ---------------DDSMRT--------------------------SQLNVGTSTDVSL 1967

Query: 2541 DCSKAGNNMLLVGVHGPRTPCEEILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGS 2720
              +++  + L   +  P    E  L+K + +R   +S+  K+ GE+ + V+   +H+  S
Sbjct: 1968 KITESDLSQLTASIRAPSGNEEPCLLKRLPNRHIGISFTPKEVGEHVVSVRKSGKHVTNS 2027

Query: 2721 PYRVLV 2738
            P+++LV
Sbjct: 2028 PFKILV 2033



 Score =  318 bits (816), Expect = 1e-86
 Identities = 258/861 (29%), Positives = 385/861 (44%), Gaps = 35/861 (4%)
 Frame = +3

Query: 258  ITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFYV-DYVNCGHVTAYGPGLSHG 434
            I DN D + TV+Y   + G   + + Y    +P SP    V   ++   +   G   S  
Sbjct: 920  IIDNHDYSYTVKYTAVQQGNMAVTVTYGGDPVPKSPFVVNVAPPLDLSKIKVQGLN-SKV 978

Query: 435  VVNKPAVFTVNTKDAG-EGGLSLAIEGPSKAEISCTDNQDGTC---SVSYLPVLPGDYSI 602
             V +   F+VNT+ AG +G L + +  PS+  I C     G     +V Y+P   G Y +
Sbjct: 979  AVGQEQAFSVNTRGAGGQGQLDVRMTSPSRRPIPCKLEPGGGAEAQAVRYMPPEEGPYKV 1038

Query: 603  LVKYNEQHIPGSPFTAR--VTGDDSMRMSH---LK---VGSAADIPINISETDLSLLTAT 758
             + Y+   +PGSPF     +  D S   ++   LK   VG+ A   I+        L  T
Sbjct: 1039 DITYDGHPVPGSPFAVEGVLPPDPSKVCAYGPGLKGGLVGTPAPFSIDTKGAGTGGLGLT 1098

Query: 759  VVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNGQHVASSPIPVVISQSEIGD 938
            V  P   +  C  +   +G   +S++P E GE+ +++     H+  SP    I    + D
Sbjct: 1099 VEGPCEAKIEC--QDNGDGSCAVSYLPTEPGEYTINILFAEAHIPGSPFKATIRP--VFD 1154

Query: 939  ASRVRVSGRGLHEGHTFEPAEFIIDTRDAGYGGLSLSI--EGPSKVDINTEDLEDGTCRV 1112
             S+VR SG GL  G   E A F +D  +AG   L++ I  +   K ++   +  DGT  +
Sbjct: 1155 PSKVRASGPGLERGKVGEAATFTVDCSEAGEAELTIEILSDAGVKAEVLIHNNADGTYHI 1214

Query: 1113 TYCPTEPGNYIINIKFADQHVPGSPF-----------SVKVTGEGRVKESITRRQRAPSV 1259
            TY P  PG Y I IK+    VP  P             VKV+G G     + R       
Sbjct: 1215 TYSPAFPGTYTITIKYGGHPVPKFPTRVHVQPAVDTSGVKVSGPGVEPHGVLREVTTEFT 1274

Query: 1260 ANVGSHCDLSLKIPEISIQDMTAQVTSPSGKSHEAEIVEGENHTYCIRFVPAEMGMHTVS 1439
             +  S       +       +TA+V +PSG   +  + +  + TY +++   E G+H V 
Sbjct: 1275 VDARS-------LTATGGNHVTARVLNPSGAKTDTYVTDNGDGTYRVQYTAYEEGVHLVE 1327

Query: 1440 VKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLERAEAGVPAEFSIWTREAGAGGLAI 1619
            V Y    VP SPF+  VG        +VRA GPGLE         F++ TR AG GGL +
Sbjct: 1328 VLYDEVAVPKSPFR--VGVTEGCDPTRVRAFGPGLEGGLVNKANRFTVETRGAGTGGLGL 1385

Query: 1620 AVEGPSKAEISFEDRKDGSCGVAYVVQEPGDYEVSVKFNEEHIPDSPFVVPVASPSGDAR 1799
            A+EGPS+A++S +D KDGSC V Y+   PGDY+V++ F    IP SPF VPV       +
Sbjct: 1386 AIEGPSEAKMSCKDNKDGSCTVEYIPFTPGDYDVNITFGGRPIPGSPFRVPVKDVVDPGK 1445

Query: 1800 RLTVSSLQESGLKVNQPASFAVSLNGA-KGAIDAKVHSPSGALEECYVTEIDQDKYAVRF 1976
                     +G++   P +F V  + A +  +   V  P+G  E   V +     + V +
Sbjct: 1446 VKCSGPGLGAGVRARVPQTFTVDCSQAGRAPLQVAVLGPTGVAEPVEVRDNGDGTHTVHY 1505

Query: 1977 IPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPGLVSAYGAGLE-GGVTGS-PAEF 2150
             P  +G Y + VK+    +P SPFKI+V  P H  D   V A G GL   G+  S P EF
Sbjct: 1506 TPATDGPYTVAVKYADQEVPRSPFKIKV-LPAH--DASKVRASGPGLNASGIPASLPVEF 1562

Query: 2151 IVNTSNAGAGALSVTIDGP--SKVKMDCQECPEG-YRVTYTPMAPGSYLISIKYGGPYHI 2321
             ++  +AG G L+V I  P     K + ++  +G Y V+Y P   G Y I+IKYGG   I
Sbjct: 1563 TIDARDAGEGLLTVQILDPEGKPKKANIRDNGDGTYTVSYLPDMSGRYTITIKYGGD-EI 1621

Query: 2322 GGSPFKARVTGHRLVSNHSLHETSSVFVDSLTKTXXXXXXXXXXXXXXXXSKVLAKGLGL 2501
              SPF+     H L +  +     +V +                            GLG 
Sbjct: 1622 PYSPFRI----HALPTGDASKCLVTVSIG-------------------------GHGLGA 1652

Query: 2502 ---SKAYVGQKGSFTVDCSKAGNNMLLVGVHGPRTPCEEILVKHVGSRLYSVSYLLKDKG 2672
                +  +GQ+   TVD   AG   +   V  P     ++ V       + + Y   + G
Sbjct: 1653 CLGPRIQIGQETVITVDAKAAGEGKVTCTVSTPDGAELDVDVVENHDGTFDIYYTAPEPG 1712

Query: 2673 EYTLVVKWGDEHIPGSPYRVL 2735
            +Y + +++G EHIP SP+ VL
Sbjct: 1713 KYVITIRFGGEHIPNSPFHVL 1733



 Score =  305 bits (782), Expect = 1e-82
 Identities = 266/894 (29%), Positives = 407/894 (45%), Gaps = 48/894 (5%)
 Frame = +3

Query: 201  KGEITGEVRMPSGKVAQPAITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFYV 380
            KG++    +   G      +  N DGT    Y P++   H + I +  +++P SP +  V
Sbjct: 699  KGDLKLYAQDADGCPIDIKVIPNGDGTFRCSYVPTKPIKHTIIISWGGVNVPKSPFRVNV 758

Query: 381  -DYVNCGHVTAYGPGLSHG--VVNKPAVFTVNTKDAGEGGLSLAIE------GPSKAEI- 530
             +  +   V  YGPG+       N+P  FTV+  +AG+G +S+ I+      GP++A+I 
Sbjct: 759  GEGSHPERVKVYGPGVEKTGLKANEPTYFTVDCSEAGQGDVSIGIKCAPGVVGPAEADID 818

Query: 531  -SCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARVTGDDSMRMSHLKVGSAA 707
                 N + T +V Y P   G Y+I+V +  Q IP SPF  +V  D S   S +K   A 
Sbjct: 819  FDIIKNDNDTFTVKYTPPGAGRYTIMVLFANQEIPASPFHIKV--DPSHDASKVK---AE 873

Query: 708  DIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVG-----------------ISFV 836
               +N +  ++   T   V   G  +  L  +      G                 + + 
Sbjct: 874  GPGLNRTGVEVGKPTHFTVLTKGAGKAKLDVQFAGTAKGEVVRDFEIIDNHDYSYTVKYT 933

Query: 837  PKETGEHLVHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEGHTFEPAEFIIDT 1016
              + G   V V   G  V  SP   V++ +   D S+++V G         E A F ++T
Sbjct: 934  AVQQGNMAVTVTYGGDPVPKSPF--VVNVAPPLDLSKIKVQGLNSKVAVGQEQA-FSVNT 990

Query: 1017 RDA-GYGGLSLSIEGPSKVDINTEDLEDG----TCRVTYCPTEPGNYIINIKFADQHVPG 1181
            R A G G L + +  PS+  I  + LE G       V Y P E G Y ++I +    VPG
Sbjct: 991  RGAGGQGQLDVRMTSPSRRPIPCK-LEPGGGAEAQAVRYMPPEEGPYKVDITYDGHPVPG 1049

Query: 1182 SPFSVKVTGEGRVKESITR-RQRAPSVAN--VGSHCDLSLKIPEISIQDMTAQVTSPSGK 1352
            SPF+V    EG +    ++     P +    VG+    S+         +   V  P   
Sbjct: 1050 SPFAV----EGVLPPDPSKVCAYGPGLKGGLVGTPAPFSIDTKGAGTGGLGLTVEGPCEA 1105

Query: 1353 SHEAEIVEGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAG 1532
              E +  +  + +  + ++P E G +T+++ +   H+PGSPF+ T+ P+ +    KVRA 
Sbjct: 1106 KIECQ--DNGDGSCAVSYLPTEPGEYTINILFAEAHIPGSPFKATIRPVFD--PSKVRAS 1161

Query: 1533 GPGLERAEAGVPAEFSIWTREAGAGGLAIAV--EGPSKAEISFEDRKDGSCGVAYVVQEP 1706
            GPGLER + G  A F++   EAG   L I +  +   KAE+   +  DG+  + Y    P
Sbjct: 1162 GPGLERGKVGEAATFTVDCSEAGEAELTIEILSDAGVKAEVLIHNNADGTYHITYSPAFP 1221

Query: 1707 GDYEVSVKFNEEHIPDSPFVVPVASPSGDARRLTVS--SLQESGLKVNQPASFAV---SL 1871
            G Y +++K+    +P  P  V V  P+ D   + VS   ++  G+       F V   SL
Sbjct: 1222 GTYTITIKYGGHPVPKFPTRVHV-QPAVDTSGVKVSGPGVEPHGVLREVTTEFTVDARSL 1280

Query: 1872 NGAKG-AIDAKVHSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPF 2048
                G  + A+V +PSGA  + YVT+     Y V++   E GV+L++V ++   +P SPF
Sbjct: 1281 TATGGNHVTARVLNPSGAKTDTYVTDNGDGTYRVQYTAYEEGVHLVEVLYDEVAVPKSPF 1340

Query: 2049 KIRVGEPGHGGDPGLVSAYGAGLEGGVTGSPAEFIVNTSNAGAGALSVTIDGPSKVKMDC 2228
            ++ V E   G DP  V A+G GLEGG+      F V T  AG G L + I+GPS+ KM C
Sbjct: 1341 RVGVTE---GCDPTRVRAFGPGLEGGLVNKANRFTVETRGAGTGGLGLAIEGPSEAKMSC 1397

Query: 2229 QECPEG-YRVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSVFV 2405
            ++  +G   V Y P  PG Y ++I +GG   I GSPF+  V                  V
Sbjct: 1398 KDNKDGSCTVEYIPFTPGDYDVNITFGG-RPIPGSPFRVPVKD---------------VV 1441

Query: 2406 DSLTKTXXXXXXXXXXXXXXXXSKVLAKGLGLS---KAYVGQKGSFTVDCSKAGNNMLLV 2576
            D                      KV   G GL    +A V Q  +FTVDCS+AG   L V
Sbjct: 1442 D--------------------PGKVKCSGPGLGAGVRARVPQ--TFTVDCSQAGRAPLQV 1479

Query: 2577 GVHGPRTPCEEILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLV 2738
             V GP    E + V+  G   ++V Y     G YT+ VK+ D+ +P SP+++ V
Sbjct: 1480 AVLGPTGVAEPVEVRDNGDGTHTVHYTPATDGPYTVAVKYADQEVPRSPFKIKV 1533



 Score =  296 bits (757), Expect = 1e-79
 Identities = 246/902 (27%), Positives = 382/902 (42%), Gaps = 57/902 (6%)
 Frame = +3

Query: 204  GEITGEVRMPSGKVAQPAITDN--KDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFY 377
            GE+   +  P G   +  +  N  KD T  V Y P  AGLH++ + +   +I  SP +  
Sbjct: 308  GEVLVYIEDPEGHTEEAKVVPNNDKDRTYAVSYVPKVAGLHKVTVLFAGQNIERSPFEVN 367

Query: 378  VDYV--NCGHVTAYGPGLSH--GVVNKPAVFTVNTKDAGEGGLSLAIEGPS----KAEIS 533
            V     +   V+A GPGL     V NKP  F + T  AG G +++ I  P       E++
Sbjct: 368  VGMALGDANKVSARGPGLEPVGNVANKPTYFDIYTAGAGTGDVAVVIVDPQGRRDTVEVA 427

Query: 534  CTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARVT----------GDDSMRMS 683
              D  D T   +Y P + G +++ V +    I  SPF   V+              ++  
Sbjct: 428  LEDKGDSTFRCTYRPAMEGPHTVHVAFAGAPITRSPFPVHVSEACNPNACRASGRGLQPK 487

Query: 684  HLKVGSAADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLV 863
             ++V   AD  +         L  TV  P G EEP  ++   +G     + P   G+++V
Sbjct: 488  GVRVKEVADFKVFTKGAGSGELKVTVKGPKGTEEPVKVREAGDGVFECEYYPVVPGKYVV 547

Query: 864  HVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEGHTFEPAEFIIDTRDAGYGGLS 1043
             +   G  +  SP  V +S        +VR  G GL  G   + A+F+++      G L 
Sbjct: 548  TITWGGYAIPRSPFEVQVSPE--AGVQKVRAWGPGLETGQVGKSADFVVEAIGTEVGTLG 605

Query: 1044 LSIEGPSKVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPF----------- 1190
             SIEGPS+  I  +D  DG+C V Y PTEPG Y +++   D+ +  SPF           
Sbjct: 606  FSIEGPSQAKIECDDKGDGSCDVRYWPTEPGEYAVHVICDDEDIRDSPFIAHILPAPPDC 665

Query: 1191 ---SVKVTGEGRVKESITRRQRAPSVANVGSHCDLSLKIPEISIQDMTAQVTSPSGKSHE 1361
                VK  G G            P+   V    + ++        D+        G   +
Sbjct: 666  FPDKVKAFGPG----------LEPTGCIVDKPAEFTIDARAAGKGDLKLYAQDADGCPID 715

Query: 1362 AEIVEGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAH--KVRAGG 1535
             +++   + T+   +VP +   HT+ + + G +VP SPF+  VG     G+H  +V+  G
Sbjct: 716  IKVIPNGDGTFRCSYVPTKPIKHTIIISWGGVNVPKSPFRVNVGE----GSHPERVKVYG 771

Query: 1536 PGLERA--EAGVPAEFSIWTREAGAGGLAIAVE------GPSKAEISFEDRK--DGSCGV 1685
            PG+E+   +A  P  F++   EAG G ++I ++      GP++A+I F+  K  + +  V
Sbjct: 772  PGVEKTGLKANEPTYFTVDCSEAGQGDVSIGIKCAPGVVGPAEADIDFDIIKNDNDTFTV 831

Query: 1686 AYVVQEPGDYEVSVKFNEEHIPDSPFVVPVASPSGDARRLTVS--SLQESGLKVNQPASF 1859
             Y     G Y + V F  + IP SPF + V  PS DA ++      L  +G++V +P  F
Sbjct: 832  KYTPPGAGRYTIMVLFANQEIPASPFHIKV-DPSHDASKVKAEGPGLNRTGVEVGKPTHF 890

Query: 1860 AVSLNGA-KGAIDAKV--HSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTH 2030
             V   GA K  +D +    +    + +  + +     Y V++   + G   + V + G  
Sbjct: 891  TVLTKGAGKAKLDVQFAGTAKGEVVRDFEIIDNHDYSYTVKYTAVQQGNMAVTVTYGGDP 950

Query: 2031 IPGSPFKIRVGEPGHGGDPGLVSAYGAGLEGGVTGSPAEFIVNTSNAGA-GALSVTIDGP 2207
            +P SPF + V  P    D   +   G   +  V G    F VNT  AG  G L V +  P
Sbjct: 951  VPKSPFVVNVAPP---LDLSKIKVQGLNSKVAV-GQEQAFSVNTRGAGGQGQLDVRMTSP 1006

Query: 2208 SKVKMDCQECP----EGYRVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNH 2375
            S+  + C+  P    E   V Y P   G Y + I Y G + + GSPF             
Sbjct: 1007 SRRPIPCKLEPGGGAEAQAVRYMPPEEGPYKVDITYDG-HPVPGSPFAVE---------- 1055

Query: 2376 SLHETSSVFVDSLTKTXXXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKA 2555
                                            SKV A G GL    VG    F++D   A
Sbjct: 1056 -------------------------GVLPPDPSKVCAYGPGLKGGLVGTPAPFSIDTKGA 1090

Query: 2556 GNNMLLVGVHGPRTPCE-EILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRV 2732
            G   L + V G   PCE +I  +  G    +VSYL  + GEYT+ + + + HIPGSP++ 
Sbjct: 1091 GTGGLGLTVEG---PCEAKIECQDNGDGSCAVSYLPTEPGEYTINILFAEAHIPGSPFKA 1147

Query: 2733 LV 2738
             +
Sbjct: 1148 TI 1149



 Score =  273 bits (699), Expect = 5e-73
 Identities = 173/478 (36%), Positives = 242/478 (50%), Gaps = 50/478 (10%)
 Frame = +3

Query: 207  EITGEVRMPSGKVAQPAITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFYVDY 386
            ++T +V  PSGKV    I + +D   +VR+ P E G H + ++Y   H+PGSP QF V  
Sbjct: 2249 DMTAQVTSPSGKVEAAEIVEGEDSAYSVRFVPQEMGPHTVAVKYRGQHVPGSPFQFTVGP 2308

Query: 387  VNCG---HVTAYGPGLSHGVVNKPAVFTVNTKDAGEGGLSLAIEGPSKAEISCTDNQDGT 557
            +  G    V A G GL  GV   PA F++ T++AG GGLS+A+EGPSKAEI+  D +DG+
Sbjct: 2309 LGEGGAHKVRAGGTGLERGVAGVPAEFSIWTREAGAGGLSIAVEGPSKAEIAFEDRKDGS 2368

Query: 558  CSVSYLPVLPGDYSILVKYNEQHIPGSPFTARVTG--DDSMRMS-------HLKVGSAAD 710
            C VSY+   PGDY + +K+N++HIP SPF   V    DD+ R++        LKV   A 
Sbjct: 2369 CGVSYVVQEPGDYEVSIKFNDEHIPDSPFVVPVASLSDDARRLTVTSLQETGLKVNQPAS 2428

Query: 711  IPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNGQHV 890
              + ++     ++ A V  PSG  E C +  L +    I F+P E G H + VK NG H+
Sbjct: 2429 FAVQLNGAR-GVIDARVHTPSGAVEECYVSELDSDKHTIRFIPHENGVHSIDVKFNGAHI 2487

Query: 891  ASSPIPVVIS-QSEIGDASRVRVSGRGLHEGHTFEPAEFIIDTRDAGYGGLSLSIEGPSK 1067
              SP  + +  QS+ GD   V   G GL  G T   +EFI++T +AG G LS++I+GPSK
Sbjct: 2488 PGSPFKIRVGEQSQAGDPGLVSAYGPGLEGGTTGVSSEFIVNTLNAGSGALSVTIDGPSK 2547

Query: 1068 VDINTEDLEDGTCRVTYCPTEPGNYIINIKF-ADQHVPGSPFSVKVTG------------ 1208
            V ++  +  +G   VTY P  PGNY+I IK+   QH+ GSPF  KVTG            
Sbjct: 2548 VQLDCRECPEGHV-VTYTPMAPGNYLIAIKYGGPQHIVGSPFKAKVTGPRLSGGHSLHET 2606

Query: 1209 -----EGRVKESITRRQ-----------------RAP--SVANVGSHCDLSLKIPEISIQ 1316
                 E   K S +R                   R P  S A VG     ++   +    
Sbjct: 2607 STVLVETVTKSSSSRGSSYSSIPKFSSDASKVVTRGPGLSQAFVGQKNSFTVDCSKAGTN 2666

Query: 1317 DMTAQVTSPSGKSHEAEIVEGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTV 1490
             M   V  P     E  +    N  Y + +   E G + + VK+  + VPGSPF+  V
Sbjct: 2667 MMMVGVHGPKTPCEEVYVKHMGNRVYNVTYTVKEKGDYILIVKWGDESVPGSPFKVKV 2724



 Score =  239 bits (609), Expect = 1e-62
 Identities = 239/840 (28%), Positives = 369/840 (43%), Gaps = 47/840 (5%)
 Frame = +3

Query: 354  PGSPLQFYVDYVNCGHVTAYGPGLSH--GVVNKPAVFTVNTKDAGEGGLSLAIEGP---- 515
            PG+P++     +N     AYGPG+      V +PA FTV T DAG G + + IE P    
Sbjct: 264  PGAPVRS--KQLNPKKAIAYGPGIEPQGNTVLQPAHFTVQTVDAGVGEVLVYIEDPEGHT 321

Query: 516  SKAEISCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARV---TGDD---SMR 677
             +A++   +++D T +VSY+P + G + + V +  Q+I  SPF   V    GD    S R
Sbjct: 322  EEAKVVPNNDKDRTYAVSYVPKVAGLHKVTVLFAGQNIERSPFEVNVGMALGDANKVSAR 381

Query: 678  MSHLK-VGSAADIP----INISETDLSLLTATVVPPSGREE--PCLLKRLRNGHVGISFV 836
               L+ VG+ A+ P    I  +      +   +V P GR +     L+   +     ++ 
Sbjct: 382  GPGLEPVGNVANKPTYFDIYTAGAGTGDVAVVIVDPQGRRDTVEVALEDKGDSTFRCTYR 441

Query: 837  PKETGEHLVHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEG--HTFEPAEFII 1010
            P   G H VHV   G  +  SP PV +  SE  + +  R SGRGL        E A+F +
Sbjct: 442  PAMEGPHTVHVAFAGAPITRSPFPVHV--SEACNPNACRASGRGLQPKGVRVKEVADFKV 499

Query: 1011 DTRDAGYGGLSLSIEGPSKVD--INTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGS 1184
             T+ AG G L ++++GP   +  +   +  DG     Y P  PG Y++ I +    +P S
Sbjct: 500  FTKGAGSGELKVTVKGPKGTEEPVKVREAGDGVFECEYYPVVPGKYVVTITWGGYAIPRS 559

Query: 1185 PFSVKVTGEGRVKESITRRQRAPSV--ANVGSHCDLSLKIPEISIQDMTAQVTSPSGKSH 1358
            PF V+V+ E  V++    R   P +    VG   D  ++     +  +   +  PS    
Sbjct: 560  PFEVQVSPEAGVQKV---RAWGPGLETGQVGKSADFVVEAIGTEVGTLGFSIEGPSQAKI 616

Query: 1359 EAEIVEGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPL-GEGGAHKVRAGG 1535
            E +  +  + +  +R+ P E G + V V    + +  SPF   + P   +    KV+A G
Sbjct: 617  ECD--DKGDGSCDVRYWPTEPGEYAVHVICDDEDIRDSPFIAHILPAPPDCFPDKVKAFG 674

Query: 1536 PGLERAEAGV--PAEFSIWTREAGAGGLAIAVEGPSKAEISFE--DRKDGSCGVAYVVQE 1703
            PGLE     V  PAEF+I  R AG G L +  +      I  +     DG+   +YV  +
Sbjct: 675  PGLEPTGCIVDKPAEFTIDARAAGKGDLKLYAQDADGCPIDIKVIPNGDGTFRCSYVPTK 734

Query: 1704 PGDYEVSVKFNEEHIPDSPFVVPVASPSGDAR-RLTVSSLQESGLKVNQPASFAVSLNGA 1880
            P  + + + +   ++P SPF V V   S   R ++    ++++GLK N+P  F V  + A
Sbjct: 735  PIKHTIIISWGGVNVPKSPFRVNVGEGSHPERVKVYGPGVEKTGLKANEPTYFTVDCSEA 794

Query: 1881 -KGAIDAKVH------SPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPG 2039
             +G +   +        P+ A  +  + + D D + V++ P   G Y I V F    IP 
Sbjct: 795  GQGDVSIGIKCAPGVVGPAEADIDFDIIKNDNDTFTVKYTPPGAGRYTIMVLFANQEIPA 854

Query: 2040 SPFKIRVGEPGHGGDPGLVSAYGAGLE--GGVTGSPAEFIVNTSNAGAGALSVTIDGPSK 2213
            SPF I+V +P H  D   V A G GL   G   G P  F V T  AG   L V   G +K
Sbjct: 855  SPFHIKV-DPSH--DASKVKAEGPGLNRTGVEVGKPTHFTVLTKGAGKAKLDVQFAGTAK 911

Query: 2214 --VKMDCQECPE---GYRVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHS 2378
              V  D +        Y V YT +  G+  +++ YGG   +  SPF   V          
Sbjct: 912  GEVVRDFEIIDNHDYSYTVKYTAVQQGNMAVTVTYGGD-PVPKSPFVVNVA--------- 961

Query: 2379 LHETSSVFVDSLTKTXXXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKA- 2555
                                           SK+  +GL  SK  VGQ+ +F+V+   A 
Sbjct: 962  --------------------------PPLDLSKIKVQGLN-SKVAVGQEQAFSVNTRGAG 994

Query: 2556 GNNMLLVGVHGP-RTPCEEILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRV 2732
            G   L V +  P R P    L    G+   +V Y+  ++G Y + + +    +PGSP+ V
Sbjct: 995  GQGQLDVRMTSPSRRPIPCKLEPGGGAEAQAVRYMPPEEGPYKVDITYDGHPVPGSPFAV 1054



 Score =  131 bits (329), Expect = 4e-30
 Identities = 91/313 (29%), Positives = 140/313 (44%), Gaps = 53/313 (16%)
 Frame = +3

Query: 138  VNGLDVTSLR---PFDLVIPFTIKKGEITGEVRMPSGKVAQPAITDNKDGTVTVRYAPSE 308
            V  L  T L+   P    +     +G I   V  PSG V +  +++      T+R+ P E
Sbjct: 2413 VTSLQETGLKVNQPASFAVQLNGARGVIDARVHTPSGAVEECYVSELDSDKHTIRFIPHE 2472

Query: 309  AGLHEMDIRYDNMHIPGSPLQFYVDYVNC----GHVTAYGPGLSHGVVNKPAVFTVNTKD 476
             G+H +D++++  HIPGSP +  V   +     G V+AYGPGL  G     + F VNT +
Sbjct: 2473 NGVHSIDVKFNGAHIPGSPFKIRVGEQSQAGDPGLVSAYGPGLEGGTTGVSSEFIVNTLN 2532

Query: 477  AGEGGLSLAIEGPSKAEISCTDNQDGTCSVSYLPVLPGDYSILVKY-NEQHIPGSPFTAR 653
            AG G LS+ I+GPSK ++ C +  +G   V+Y P+ PG+Y I +KY   QHI GSPF A+
Sbjct: 2533 AGSGALSVTIDGPSKVQLDCRECPEGHV-VTYTPMAPGNYLIAIKYGGPQHIVGSPFKAK 2591

Query: 654  VTG----------------------DDSMR-----------------------MSHLKVG 698
            VTG                        S R                       +S   VG
Sbjct: 2592 VTGPRLSGGHSLHETSTVLVETVTKSSSSRGSSYSSIPKFSSDASKVVTRGPGLSQAFVG 2651

Query: 699  SAADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKN 878
                  ++ S+   +++   V  P    E   +K + N    +++  KE G++++ VK  
Sbjct: 2652 QKNSFTVDCSKAGTNMMMVGVHGPKTPCEEVYVKHMGNRVYNVTYTVKEKGDYILIVKWG 2711

Query: 879  GQHVASSPIPVVI 917
             + V  SP  V +
Sbjct: 2712 DESVPGSPFKVKV 2724


>ref|NP_079464.2| tripartite motif-containing protein 45 isoform 1 [Homo sapiens].
          Length = 580

 Score = 52.8 bits (125), Expect = 2e-06
 Identities = 33/105 (31%), Positives = 52/105 (49%), Gaps = 11/105 (10%)
 Frame = +3

Query: 936  DASRVRVSGRGLHEGHTFEPAEFIIDTRDA-----GYGGLSLSI------EGPSKVDINT 1082
            D ++  + G  LH     + A F +  +DA     G GG ++ +      +  S V    
Sbjct: 398  DPAKCVLQGEDLHRAREKQTASFTLLCKDAAGEIMGRGGDNVQVAVVPKDKKDSPVRTMV 457

Query: 1083 EDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTGEGR 1217
            +D +DGT  ++Y P EPG Y + +   +QHV GSPF+V V  + R
Sbjct: 458  QDNKDGTYYISYTPKEPGVYTVWVCIKEQHVQGSPFTVMVRRKHR 502



 Score = 50.8 bits (120), Expect = 7e-06
 Identities = 33/92 (35%), Positives = 44/92 (47%), Gaps = 11/92 (11%)
 Frame = +3

Query: 414 GPGLSHGVVNKPAVFTVNTKDA-----GEGGLSLAI------EGPSKAEISCTDNQDGTC 560
           G  L      + A FT+  KDA     G GG ++ +      +  S       DN+DGT 
Sbjct: 406 GEDLHRAREKQTASFTLLCKDAAGEIMGRGGDNVQVAVVPKDKKDSPVRTMVQDNKDGTY 465

Query: 561 SVSYLPVLPGDYSILVKYNEQHIPGSPFTARV 656
            +SY P  PG Y++ V   EQH+ GSPFT  V
Sbjct: 466 YISYTPKEPGVYTVWVCIKEQHVQGSPFTVMV 497


  Database: RefSeq49_HP.fasta
    Posted date:  Oct 17, 2011  1:42 PM
  Number of letters in database: 18,297,164
  Number of sequences in database:  32,964
  
Lambda     K      H
   0.318    0.134    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 32964
Number of Hits to DB: 126,796,454
Number of extensions: 3913684
Number of successful extensions: 23299
Number of sequences better than 1.0e-05: 9
Number of HSP's gapped: 21367
Number of HSP's successfully gapped: 124
Length of query: 1029
Length of database: 18,297,164
Length adjustment: 113
Effective length of query: 916
Effective length of database: 14,572,232
Effective search space: 13348164512
Effective search space used: 13348164512
Neighboring words threshold: 12
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 36 (18.5 bits)

BLASTX 2.2.24 [Aug-08-2010]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= 20110601C-007518
         (3088 letters)

Database: RefSeq49_MP.fasta 
           30,036 sequences; 15,617,559 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

Alignment   gi|NP_034357.2| filamin-A [Mus musculus].                           1744   0.0  
Alignment   gi|NP_598841.1| filamin-B [Mus musculus].                           1292   0.0  
Alignment   gi|NP_001074654.1| filamin-C [Mus musculus].                         798   0.0  
Alignment   gi|NP_001159425.1| tripartite motif-containing protein 45 isofo...    55   4e-07
Alignment   gi|NP_001159424.1| tripartite motif-containing protein 45 isofo...    55   4e-07
Alignment   gi|NP_919324.2| tripartite motif-containing protein 45 isoform ...    55   4e-07

>ref|NP_034357.2| filamin-A [Mus musculus].
          Length = 2639

 Score = 1744 bits (4517), Expect = 0.0
 Identities = 856/913 (93%), Positives = 875/913 (95%)
 Frame = +3

Query: 3    PFQVTALAGEQPSVXXXXXXXXXXXXYTYAQGGQQTWAPERPLVGVNGLDVTSLRPFDLV 182
            PFQVTALAG+QP+V            Y Y QG QQTW PERP+VGVNGLDVTSLRPFDLV
Sbjct: 1727 PFQVTALAGDQPTVQTPLRSQQLAPQYNYPQGSQQTWIPERPMVGVNGLDVTSLRPFDLV 1786

Query: 183  IPFTIKKGEITGEVRMPSGKVAQPAITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGS 362
            IPFTIKKGEITGEVRMPSGKVAQP+ITDNKDGTVTVRY+PSEAGLHEMDIRYDNMHIPGS
Sbjct: 1787 IPFTIKKGEITGEVRMPSGKVAQPSITDNKDGTVTVRYSPSEAGLHEMDIRYDNMHIPGS 1846

Query: 363  PLQFYVDYVNCGHVTAYGPGLSHGVVNKPAVFTVNTKDAGEGGLSLAIEGPSKAEISCTD 542
            PLQFYVDYVNCGH+TAYGPGL+HGVVNKPA FTVNTKDAGEGGLSLAIEGPSKAEISCTD
Sbjct: 1847 PLQFYVDYVNCGHITAYGPGLTHGVVNKPATFTVNTKDAGEGGLSLAIEGPSKAEISCTD 1906

Query: 543  NQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARVTGDDSMRMSHLKVGSAADIPIN 722
            NQDGTCSVSYLPVLPGDYSILVKYN+QHIPGSPFTARVTGDDSMRMSHLKVGSAADIPIN
Sbjct: 1907 NQDGTCSVSYLPVLPGDYSILVKYNDQHIPGSPFTARVTGDDSMRMSHLKVGSAADIPIN 1966

Query: 723  ISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNGQHVASSP 902
            ISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNGQHVASSP
Sbjct: 1967 ISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNGQHVASSP 2026

Query: 903  IPVVISQSEIGDASRVRVSGRGLHEGHTFEPAEFIIDTRDAGYGGLSLSIEGPSKVDINT 1082
            IPVVISQSEIGDASRVRVSG+GLHEGHTFEPAEFIIDTRDAGYGGLSLSIEGPSKVDINT
Sbjct: 2027 IPVVISQSEIGDASRVRVSGQGLHEGHTFEPAEFIIDTRDAGYGGLSLSIEGPSKVDINT 2086

Query: 1083 EDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTGEGRVKESITRRQRAPSVA 1262
            EDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTGEGRVKESITRR+RAPSVA
Sbjct: 2087 EDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTGEGRVKESITRRRRAPSVA 2146

Query: 1263 NVGSHCDLSLKIPEISIQDMTAQVTSPSGKSHEAEIVEGENHTYCIRFVPAEMGMHTVSV 1442
            N+GSHCDLSLKIPEISIQDMTAQVTSPSGK+HEAEIVEGENHTYCIRFVPAEMGMHTVSV
Sbjct: 2147 NIGSHCDLSLKIPEISIQDMTAQVTSPSGKTHEAEIVEGENHTYCIRFVPAEMGMHTVSV 2206

Query: 1443 KYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLERAEAGVPAEFSIWTREAGAGGLAIA 1622
            KYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLERAE GVPAEF IWTREAGAGGLAIA
Sbjct: 2207 KYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLERAEVGVPAEFGIWTREAGAGGLAIA 2266

Query: 1623 VEGPSKAEISFEDRKDGSCGVAYVVQEPGDYEVSVKFNEEHIPDSPFVVPVASPSGDARR 1802
            VEGPSKAEISFEDRKDGSCGVAYVVQEPGDYEVSVKFNEEHIPDSPFVVPVASPSGDARR
Sbjct: 2267 VEGPSKAEISFEDRKDGSCGVAYVVQEPGDYEVSVKFNEEHIPDSPFVVPVASPSGDARR 2326

Query: 1803 LTVSSLQESGLKVNQPASFAVSLNGAKGAIDAKVHSPSGALEECYVTEIDQDKYAVRFIP 1982
            LTVSSLQESGLKVNQPASFAVSLNGAKGAIDAKVHSPSGALEECYVTEIDQDKYAVRFIP
Sbjct: 2327 LTVSSLQESGLKVNQPASFAVSLNGAKGAIDAKVHSPSGALEECYVTEIDQDKYAVRFIP 2386

Query: 1983 RENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPGLVSAYGAGLEGGVTGSPAEFIVNT 2162
            RENG+YLIDVKFNGTHIPGSPFKIRVGEPGHGGDPGLVSAYGAGLEGGVTGSPAEFIVNT
Sbjct: 2387 RENGIYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPGLVSAYGAGLEGGVTGSPAEFIVNT 2446

Query: 2163 SNAGAGALSVTIDGPSKVKMDCQECPEGYRVTYTPMAPGSYLISIKYGGPYHIGGSPFKA 2342
            SNAGAGALSVTIDGPSKVKMDCQECPEGYRVTYTPMAPGSYLISIKYGGPYHIGGSPFKA
Sbjct: 2447 SNAGAGALSVTIDGPSKVKMDCQECPEGYRVTYTPMAPGSYLISIKYGGPYHIGGSPFKA 2506

Query: 2343 RVTGHRLVSNHSLHETSSVFVDSLTKTXXXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQ 2522
            +VTG RLVSNHSLHETSSVFVDSLTK                 SKV+AKGLGLSKAYVGQ
Sbjct: 2507 KVTGPRLVSNHSLHETSSVFVDSLTKVATVPQHATSGPGPADVSKVVAKGLGLSKAYVGQ 2566

Query: 2523 KGSFTVDCSKAGNNMLLVGVHGPRTPCEEILVKHVGSRLYSVSYLLKDKGEYTLVVKWGD 2702
            K +FTVDCSKAGNNMLLVGVHGPRTPCEEILVKH+GSRLYSVSYLLKDKGEYTLVVKWGD
Sbjct: 2567 KSNFTVDCSKAGNNMLLVGVHGPRTPCEEILVKHMGSRLYSVSYLLKDKGEYTLVVKWGD 2626

Query: 2703 EHIPGSPYRVLVP 2741
            EHIPGSPYR++VP
Sbjct: 2627 EHIPGSPYRIMVP 2639



 Score =  426 bits (1096), Expect = e-119
 Identities = 279/877 (31%), Positives = 437/877 (49%), Gaps = 46/877 (5%)
 Frame = +3

Query: 246  AQPAITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFYV-DYVNCGHVTAYGPG 422
            A+ +  DNKDG+ +V Y P EAG + +++ Y    +PGSP +  V D  +   V   GPG
Sbjct: 1398 AKMSCMDNKDGSCSVEYIPYEAGTYSLNVTYGGHQVPGSPFKVPVHDVTDASKVKCSGPG 1457

Query: 423  LSHGVV--NKPAVFTVNTKDAGEGGLSLAIEGPSKA--EISCTDNQDGTCSVSYLPVLPG 590
            LS G+V  N P  F V+T  AG   L + ++GP      +   DN DGT +V+Y+P   G
Sbjct: 1458 LSPGMVRANLPQSFQVDTSKAGVAPLQVKVQGPKGLVEPVDVVDNADGTQTVNYVPSREG 1517

Query: 591  DYSILVKYNEQHIPGSPFTARV--TGDDS--------MRMSHLKVGSAADIPINISETDL 740
             YSI V Y E+ +P SPF  +V  T D S        +  + +      +  I+  +   
Sbjct: 1518 SYSISVLYGEEEVPRSPFKVKVLPTHDASKVKASGPGLNTTGVPASLPVEFTIDAKDAGE 1577

Query: 741  SLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNGQHVASSPIPVVIS 920
             LL   +  P G+ +   ++   +G   +++VP   G + + +K  G  +  SP  V   
Sbjct: 1578 GLLAVQITDPEGKPKKTHIQDNHDGTYTVAYVPDVPGRYTILIKYGGDEIPFSPYRVRAV 1637

Query: 921  QSEIGDASRVRVSGRGLHEGHTFEPAE---FIIDTRDAGYGGLSLSIEGP--SKVDINTE 1085
             +  GDAS+  V+G G+  G T +  E     +DT+ AG G ++ ++  P  S+VD++  
Sbjct: 1638 PT--GDASKCTVTGAGI--GPTIQIGEETVITVDTKAAGKGKVTCTVCTPDGSEVDVDVV 1693

Query: 1086 DLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTG--EGRVKESITRRQRAPSV 1259
            + EDGT  + Y   +PG Y+I ++F  +HVP SPF V      +  V+  +  +Q AP  
Sbjct: 1694 ENEDGTFDIFYTAPQPGKYVICVRFGGEHVPNSPFQVTALAGDQPTVQTPLRSQQLAPQY 1753

Query: 1260 ---------------------ANVGSHCDLSLKIP-EISIQDMTAQVTSPSGKSHEAEIV 1373
                                  +V S     L IP  I   ++T +V  PSGK  +  I 
Sbjct: 1754 NYPQGSQQTWIPERPMVGVNGLDVTSLRPFDLVIPFTIKKGEITGEVRMPSGKVAQPSIT 1813

Query: 1374 EGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLERA 1553
            + ++ T  +R+ P+E G+H + ++Y   H+PGSP QF V  +  G    + A GPGL   
Sbjct: 1814 DNKDGTVTVRYSPSEAGLHEMDIRYDNMHIPGSPLQFYVDYVNCG---HITAYGPGLTHG 1870

Query: 1554 EAGVPAEFSIWTREAGAGGLAIAVEGPSKAEISFEDRKDGSCGVAYVVQEPGDYEVSVKF 1733
                PA F++ T++AG GGL++A+EGPSKAEIS  D +DG+C V+Y+   PGDY + VK+
Sbjct: 1871 VVNKPATFTVNTKDAGEGGLSLAIEGPSKAEISCTDNQDGTCSVSYLPVLPGDYSILVKY 1930

Query: 1734 NEEHIPDSPFVVPVASPSGDARRLTVSSLQESGLKVNQPASFAVSLNGAK-GAIDAKVHS 1910
            N++HIP SPF   V   +GD       S++ S LKV   A   ++++      + A V  
Sbjct: 1931 NDQHIPGSPFTARV---TGD------DSMRMSHLKVGSAADIPINISETDLSLLTATVVP 1981

Query: 1911 PSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPG 2090
            PSG  E C +  +      + F+P+E G +L+ VK NG H+  SP  + + +    GD  
Sbjct: 1982 PSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNGQHVASSPIPVVISQ-SEIGDAS 2040

Query: 2091 LVSAYGAGLEGGVTGSPAEFIVNTSNAGAGALSVTIDGPSKVKMDCQECPEG-YRVTYTP 2267
             V   G GL  G T  PAEFI++T +AG G LS++I+GPSKV ++ ++  +G  RVTY P
Sbjct: 2041 RVRVSGQGLHEGHTFEPAEFIIDTRDAGYGGLSLSIEGPSKVDINTEDLEDGTCRVTYCP 2100

Query: 2268 MAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSVFVDSLTKTXXXXXXXX 2447
              PG+Y+I+IK+    H+ GSPF  +VTG   V             +S+T+         
Sbjct: 2101 TEPGNYIINIKF-ADQHVPGSPFSVKVTGEGRVK------------ESITR--------- 2138

Query: 2448 XXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKAGNNMLLVGVHGPRTPCEEILVKHV 2627
                         +    S A +G     ++   +     +   V  P     E  +   
Sbjct: 2139 -------------RRRAPSVANIGSHCDLSLKIPEISIQDMTAQVTSPSGKTHEAEIVEG 2185

Query: 2628 GSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLV 2738
             +  Y + ++  + G +T+ VK+  +H+PGSP++  V
Sbjct: 2186 ENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTV 2222



 Score =  353 bits (906), Expect = 5e-97
 Identities = 266/884 (30%), Positives = 413/884 (46%), Gaps = 39/884 (4%)
 Frame = +3

Query: 204  GEITGEVRMPSGK--VAQPAITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFY 377
            GE+   ++ P+G+    +P +    D T    Y P+  G+H + + +  + IP SP    
Sbjct: 414  GEVEVVIQDPTGQKGTVEPQLEARGDSTYRCSYQPTMEGVHTVHVTFAGVPIPRSPYTVT 473

Query: 378  VDYV-NCGHVTAYGPGLS-HGV-VNKPAVFTVNTKDAGEGGLSLAIEGPSKAE-ISCTDN 545
            V    N     A G GL   GV V + A F V TK AG G L + ++GP   E +   D 
Sbjct: 474  VGQACNPAACRAIGRGLQPKGVRVKETADFKVYTKGAGSGELKVTVKGPKGEERVKQKDL 533

Query: 546  QDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARV---TGDDSMR-----MSHLKVGS 701
             DG     Y P +PG Y++ + +  Q+I  SPF  +V    G+  +R     +    VG 
Sbjct: 534  GDGVYGFEYYPTIPGTYTVTITWGGQNIGRSPFEVKVGTECGNQKVRAWGPGLEGGIVGK 593

Query: 702  AADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNG 881
            +AD  +     D+  L  +V  PS  +  C  K   +G   + + P+E GE+ VHV  N 
Sbjct: 594  SADFVVEAIGDDVGTLGFSVEGPSQAKIECDDKG--DGSCDVRYWPQEAGEYAVHVLCNS 651

Query: 882  QHVASSPIPVVISQS-EIGDASRVRVSGRGLHEGHTF--EPAEFIIDTRDAGYGGLSLSI 1052
            + +  SP    I ++ +     RV+  G GL +      +PAEF +D + AG   L + +
Sbjct: 652  EDIRLSPFMADIREAPQDFHPDRVKARGPGLEKTGVAVNKPAEFTVDAKHAGKAPLRVQV 711

Query: 1053 EGPS--KVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTGEGRVKE 1226
            +      V+   +D  +GT   +Y P +P  +   + +    +P SPF V V G G    
Sbjct: 712  QDNEGCSVEATVKDNGNGTYSCSYVPRKPVKHTAMVSWGGVSIPNSPFRVNV-GAGSHPN 770

Query: 1227 SITRRQRAPSVANVG--SHCDLSLKIP-------EISIQDMTAQ-VTSPSGKSHEAEIVE 1376
             +  +   P VA  G  +H      +        ++SI    A  V  P+    + +I+ 
Sbjct: 771  KV--KVYGPGVAKTGLKAHEPTYFTVDCTEAGQGDVSIGIKCAPGVVGPTEADIDFDIIR 828

Query: 1377 GENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLERA- 1553
             +N T+ +++ P   G +T+ V +  Q  P SP +  V P  +  A KV+A GPGL R  
Sbjct: 829  NDNDTFTVKYTPCGAGSYTIMVLFADQATPTSPIRVKVEPSHD--ASKVKAEGPGLNRTG 886

Query: 1554 -EAGVPAEFSIWTREAGAGGLAIAVEGPSKAE----ISFEDRKDGSCGVAYVVQEPGDYE 1718
             E G P  F++  + AG G L +   G +K +    +   D  D +  V Y+  + G   
Sbjct: 887  VELGKPTHFTVNAKTAGKGKLDVQFSGLAKGDAVRDVDIIDHHDNTYTVKYIPVQQGPVG 946

Query: 1719 VSVKFNEEHIPDSPFVVPVASPSGDARRLTVSSLQESGLKVNQPASFAVSLNGA--KGAI 1892
            V+V +  +HIP SPF V V SPS D  ++ VS L +  + V +   F V   GA  +G +
Sbjct: 947  VNVTYGGDHIPKSPFSVGV-SPSLDLSKIKVSGLGDK-VDVGKDQEFTVKSKGAGGQGKV 1004

Query: 1893 DAKVHSPSGALEECYVTE-IDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEP 2069
             +K+ SPSGA   C V   +  D   VRF+PRE G Y ++V ++G  +PGSPF +    P
Sbjct: 1005 ASKIVSPSGAAVPCKVEPGLGADNSVVRFVPREEGPYEVEVTYDGVPVPGSPFPLEAVAP 1064

Query: 2070 GHGGDPGLVSAYGAGLEGGVTGSPAEFIVNTSNAGAGALSVTIDGPSKVKMDCQECPEGY 2249
                 P  V A+G GL+GG  GSPA F ++T  AG G L +T++GP + +++C +  +G 
Sbjct: 1065 TK---PSKVKAFGPGLQGGNAGSPARFTIDTKGAGTGGLGLTVEGPCEAQLECLDNGDGT 1121

Query: 2250 -RVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSVFVDSLTKTX 2426
              V+Y P  PG Y I+I +    HI GSPFKA V                          
Sbjct: 1122 CSVSYVPTEPGDYNINILFADT-HIPGSPFKAHVA------------------------- 1155

Query: 2427 XXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKAGNNMLLVGVHGPRTPCE 2606
                           SKV   G GL +A  G+ G F VDCS AG+  L + +        
Sbjct: 1156 ----------PCFDASKVKCSGPGLERATAGEVGQFQVDCSSAGSAELTIEICSEAGLPA 1205

Query: 2607 EILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLV 2738
            E+ ++  G   ++++Y+    G YT+ +K+G + +P  P ++ V
Sbjct: 1206 EVYIQDHGDGTHTITYIPLCPGAYTVTIKYGGQPVPNFPSKLQV 1249



 Score =  321 bits (823), Expect = 2e-87
 Identities = 230/755 (30%), Positives = 358/755 (47%), Gaps = 38/755 (5%)
 Frame = +3

Query: 189  FTIK------KGEITGEVRMPSG-----KVAQPAITDNKDGTVTVRYAPSEAGLHEMDIR 335
            FT+K      +G++  ++  PSG     KV      DN      VR+ P E G +E+++ 
Sbjct: 991  FTVKSKGAGGQGKVASKIVSPSGAAVPCKVEPGLGADNS----VVRFVPREEGPYEVEVT 1046

Query: 336  YDNMHIPGSPLQFY-VDYVNCGHVTAYGPGLSHGVVNKPAVFTVNTKDAGEGGLSLAIEG 512
            YD + +PGSP     V       V A+GPGL  G    PA FT++TK AG GGL L +EG
Sbjct: 1047 YDGVPVPGSPFPLEAVAPTKPSKVKAFGPGLQGGNAGSPARFTIDTKGAGTGGLGLTVEG 1106

Query: 513  PSKAEISCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARVTG--DDSM---- 674
            P +A++ C DN DGTCSVSY+P  PGDY+I + + + HIPGSPF A V    D S     
Sbjct: 1107 PCEAQLECLDNGDGTCSVSYVPTEPGDYNINILFADTHIPGSPFKAHVAPCFDASKVKCS 1166

Query: 675  --RMSHLKVGSAADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKET 848
               +     G      ++ S    + LT  +   +G      ++   +G   I+++P   
Sbjct: 1167 GPGLERATAGEVGQFQVDCSSAGSAELTIEICSEAGLPAEVYIQDHGDGTHTITYIPLCP 1226

Query: 849  GEHLVHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEGHTFEPA--EFIIDTR- 1019
            G + V +K  GQ V + P  + +  +   D S V+  G G+     F  A  EF +D R 
Sbjct: 1227 GAYTVTIKYGGQPVPNFPSKLQVEPAV--DTSGVQCYGPGIEGQGVFREATTEFSVDARA 1284

Query: 1020 --DAGYGGLSLSIEGPS--KVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSP 1187
                G   +   +  PS    D   +D  DGT +V Y P E G + +++ +    VP SP
Sbjct: 1285 LTQTGGPHVKARVANPSGNLTDTYVQDCGDGTYKVEYTPYEEGVHSVDVTYDGSPVPSSP 1344

Query: 1188 FSVKVTGEGRVKESITRRQRAPSVANVGSHCDLSLKIPEISIQDMTAQVTSPSGKSHEAE 1367
            F V VT EG     +                  +++        +   V  PS    +  
Sbjct: 1345 FQVPVT-EGCDPSRVRVHGPGIQSGTTNKPNKFTVETRGAGTGGLGLAVEGPS--EAKMS 1401

Query: 1368 IVEGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLE 1547
             ++ ++ +  + ++P E G ++++V Y G  VPGSPF+  V  + +  A KV+  GPGL 
Sbjct: 1402 CMDNKDGSCSVEYIPYEAGTYSLNVTYGGHQVPGSPFKVPVHDVTD--ASKVKCSGPGLS 1459

Query: 1548 --RAEAGVPAEFSIWTREAGAGGLAIAVEGPS--KAEISFEDRKDGSCGVAYVVQEPGDY 1715
                 A +P  F + T +AG   L + V+GP      +   D  DG+  V YV    G Y
Sbjct: 1460 PGMVRANLPQSFQVDTSKAGVAPLQVKVQGPKGLVEPVDVVDNADGTQTVNYVPSREGSY 1519

Query: 1716 EVSVKFNEEHIPDSPFVVPVASPSGDARRLTVS--SLQESGLKVNQPASFAVSLNGA-KG 1886
             +SV + EE +P SPF V V  P+ DA ++  S   L  +G+  + P  F +    A +G
Sbjct: 1520 SISVLYGEEEVPRSPFKVKVL-PTHDASKVKASGPGLNTTGVPASLPVEFTIDAKDAGEG 1578

Query: 1887 AIDAKVHSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGE 2066
             +  ++  P G  ++ ++ +     Y V ++P   G Y I +K+ G  IP SP+++R   
Sbjct: 1579 LLAVQITDPEGKPKKTHIQDNHDGTYTVAYVPDVPGRYTILIKYGGDEIPFSPYRVRAVP 1638

Query: 2067 PGHGGDPGLVSAYGAGLEGGV-TGSPAEFIVNTSNAGAGALSVTIDGP--SKVKMDCQEC 2237
                GD    +  GAG+   +  G      V+T  AG G ++ T+  P  S+V +D  E 
Sbjct: 1639 T---GDASKCTVTGAGIGPTIQIGEETVITVDTKAAGKGKVTCTVCTPDGSEVDVDVVEN 1695

Query: 2238 PEG-YRVTYTPMAPGSYLISIKYGGPYHIGGSPFK 2339
             +G + + YT   PG Y+I +++GG  H+  SPF+
Sbjct: 1696 EDGTFDIFYTAPQPGKYVICVRFGGE-HVPNSPFQ 1729



 Score =  291 bits (745), Expect = 2e-78
 Identities = 249/893 (27%), Positives = 388/893 (43%), Gaps = 47/893 (5%)
 Frame = +3

Query: 201  KGEITGEVRMPSGKVAQPAITDNKDG--TVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQF 374
            +GE+   V  P+G   +  +T N D   T +V Y P   G H++ + +   HI  SP + 
Sbjct: 313  QGEVLVYVEDPAGHQEEAKVTANNDKNRTFSVWYVPEVTGTHKVTVLFAGQHIAKSPFEV 372

Query: 375  YVD--YVNCGHVTAYGPGL--SHGVVNKPAVFTVNTKDAGEGGLSLAIEGPS----KAEI 530
            YVD    +   VTA GPGL  S  + NK   F + T  AG G + + I+ P+      E 
Sbjct: 373  YVDKSQGDASKVTAQGPGLEPSGNIANKTTYFEIFTAGAGMGEVEVVIQDPTGQKGTVEP 432

Query: 531  SCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARV----------TGDDSMRM 680
                  D T   SY P + G +++ V +    IP SP+T  V               ++ 
Sbjct: 433  QLEARGDSTYRCSYQPTMEGVHTVHVTFAGVPIPRSPYTVTVGQACNPAACRAIGRGLQP 492

Query: 681  SHLKVGSAADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHL 860
              ++V   AD  +         L  TV  P G EE    K L +G  G  + P   G + 
Sbjct: 493  KGVRVKETADFKVYTKGAGSGELKVTVKGPKG-EERVKQKDLGDGVYGFEYYPTIPGTYT 551

Query: 861  VHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEGHTFEPAEFIIDTRDAGYGGL 1040
            V +   GQ++  SP  V +  +E G+  +VR  G GL  G   + A+F+++      G L
Sbjct: 552  VTITWGGQNIGRSPFEVKVG-TECGN-QKVRAWGPGLEGGIVGKSADFVVEAIGDDVGTL 609

Query: 1041 SLSIEGPSKVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTGEGRV 1220
              S+EGPS+  I  +D  DG+C V Y P E G Y +++    + +  SPF   +    + 
Sbjct: 610  GFSVEGPSQAKIECDDKGDGSCDVRYWPQEAGEYAVHVLCNSEDIRLSPFMADIREAPQD 669

Query: 1221 KESITRRQRAPSVANVG----SHCDLSLKIPEISIQDMTAQVTSPSGKSHEAEIVEGENH 1388
                  + R P +   G       + ++         +  QV    G S EA + +  N 
Sbjct: 670  FHPDRVKARGPGLEKTGVAVNKPAEFTVDAKHAGKAPLRVQVQDNEGCSVEATVKDNGNG 729

Query: 1389 TYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAH--KVRAGGPGLERA--E 1556
            TY   +VP +   HT  V + G  +P SPF+  VG     G+H  KV+  GPG+ +   +
Sbjct: 730  TYSCSYVPRKPVKHTAMVSWGGVSIPNSPFRVNVG----AGSHPNKVKVYGPGVAKTGLK 785

Query: 1557 AGVPAEFSIWTREAGAGGLAIAVE------GPSKAEISFE--DRKDGSCGVAYVVQEPGD 1712
            A  P  F++   EAG G ++I ++      GP++A+I F+     + +  V Y     G 
Sbjct: 786  AHEPTYFTVDCTEAGQGDVSIGIKCAPGVVGPTEADIDFDIIRNDNDTFTVKYTPCGAGS 845

Query: 1713 YEVSVKFNEEHIPDSPFVVPVASPSGDARRLTVS--SLQESGLKVNQPASFAVSLNGA-K 1883
            Y + V F ++  P SP  V V  PS DA ++      L  +G+++ +P  F V+   A K
Sbjct: 846  YTIMVLFADQATPTSPIRVKV-EPSHDASKVKAEGPGLNRTGVELGKPTHFTVNAKTAGK 904

Query: 1884 GAIDAKVH--SPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIR 2057
            G +D +    +   A+ +  + +   + Y V++IP + G   ++V + G HIP SPF + 
Sbjct: 905  GKLDVQFSGLAKGDAVRDVDIIDHHDNTYTVKYIPVQQGPVGVNVTYGGDHIPKSPFSVG 964

Query: 2058 VGEPGHGGDPGLVSAYGAGLEGGVTGSPAEFIVNTSNAGA-GALSVTIDGPSKVKMDCQE 2234
            V       D   +   G G +  V G   EF V +  AG  G ++  I  PS   + C+ 
Sbjct: 965  VSP---SLDLSKIKVSGLGDKVDV-GKDQEFTVKSKGAGGQGKVASKIVSPSGAAVPCKV 1020

Query: 2235 CP----EGYRVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSVF 2402
             P    +   V + P   G Y + + Y G   + GSPF                      
Sbjct: 1021 EPGLGADNSVVRFVPREEGPYEVEVTYDG-VPVPGSPFP--------------------- 1058

Query: 2403 VDSLTKTXXXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKAGNNMLLVGV 2582
            ++++  T                SKV A G GL     G    FT+D   AG   L + V
Sbjct: 1059 LEAVAPT--------------KPSKVKAFGPGLQGGNAGSPARFTIDTKGAGTGGLGLTV 1104

Query: 2583 HGPRTPCE-EILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLV 2738
             G   PCE ++     G    SVSY+  + G+Y + + + D HIPGSP++  V
Sbjct: 1105 EG---PCEAQLECLDNGDGTCSVSYVPTEPGDYNINILFADTHIPGSPFKAHV 1154



 Score =  231 bits (589), Expect = 3e-60
 Identities = 232/841 (27%), Positives = 368/841 (43%), Gaps = 50/841 (5%)
 Frame = +3

Query: 354  PGSPLQFYVDYVNCGHVTAYGPGL--SHGVVNKPAVFTVNTKDAGEGGLSLAIEGPS--- 518
            PG+PL+     +N     AYGPG+  +  +V K A FTV T+ AG+G + + +E P+   
Sbjct: 271  PGAPLR---PKLNPKKARAYGPGIEPTGNMVKKRAEFTVETRSAGQGEVLVYVEDPAGHQ 327

Query: 519  -KAEISCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARV--TGDDSMRMSHL 689
             +A+++  ++++ T SV Y+P + G + + V +  QHI  SPF   V  +  D+ +++  
Sbjct: 328  EEAKVTANNDKNRTFSVWYVPEVTGTHKVTVLFAGQHIAKSPFEVYVDKSQGDASKVTAQ 387

Query: 690  KVGSAADIPINISETDLSLLTA---------TVVPPSGRE---EPCLLKRLRNGHVGISF 833
              G      I    T   + TA          +  P+G++   EP L  R  +     S+
Sbjct: 388  GPGLEPSGNIANKTTYFEIFTAGAGMGEVEVVIQDPTGQKGTVEPQLEAR-GDSTYRCSY 446

Query: 834  VPKETGEHLVHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEG--HTFEPAEFI 1007
             P   G H VHV   G  +  SP  V + Q+   + +  R  GRGL        E A+F 
Sbjct: 447  QPTMEGVHTVHVTFAGVPIPRSPYTVTVGQA--CNPAACRAIGRGLQPKGVRVKETADFK 504

Query: 1008 IDTRDAGYGGLSLSIEGPSKVD-INTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGS 1184
            + T+ AG G L ++++GP   + +  +DL DG     Y PT PG Y + I +  Q++  S
Sbjct: 505  VYTKGAGSGELKVTVKGPKGEERVKQKDLGDGVYGFEYYPTIPGTYTVTITWGGQNIGRS 564

Query: 1185 PFSVKVTGE-GRVKESITRRQRAPSVAN--VGSHCDLSLKIPEISIQDMTAQVTSPSGKS 1355
            PF VKV  E G  K     R   P +    VG   D  ++     +  +   V  PS   
Sbjct: 565  PFEVKVGTECGNQKV----RAWGPGLEGGIVGKSADFVVEAIGDDVGTLGFSVEGPSQAK 620

Query: 1356 HEAEIVEGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEG-GAHKVRAG 1532
             E +  +  + +  +R+ P E G + V V    + +  SPF   +    +     +V+A 
Sbjct: 621  IECD--DKGDGSCDVRYWPQEAGEYAVHVLCNSEDIRLSPFMADIREAPQDFHPDRVKAR 678

Query: 1533 GPGLERAEAGV--PAEFSIWTREAGAGGLAIAVEGPS--KAEISFEDRKDGSCGVAYVVQ 1700
            GPGLE+    V  PAEF++  + AG   L + V+       E + +D  +G+   +YV +
Sbjct: 679  GPGLEKTGVAVNKPAEFTVDAKHAGKAPLRVQVQDNEGCSVEATVKDNGNGTYSCSYVPR 738

Query: 1701 EPGDYEVSVKFNEEHIPDSPFVVPVASPSGDAR-RLTVSSLQESGLKVNQPASFAVSLNG 1877
            +P  +   V +    IP+SPF V V + S   + ++    + ++GLK ++P  F V    
Sbjct: 739  KPVKHTAMVSWGGVSIPNSPFRVNVGAGSHPNKVKVYGPGVAKTGLKAHEPTYFTVDCTE 798

Query: 1878 A-KGAIDAKVH------SPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIP 2036
            A +G +   +        P+ A  +  +   D D + V++ P   G Y I V F     P
Sbjct: 799  AGQGDVSIGIKCAPGVVGPTEADIDFDIIRNDNDTFTVKYTPCGAGSYTIMVLFADQATP 858

Query: 2037 GSPFKIRVGEPGHGGDPGLVSAYGAGLE--GGVTGSPAEFIVNTSNAGAGALSVTIDGPS 2210
             SP +++V EP H  D   V A G GL   G   G P  F VN   AG G L V   G +
Sbjct: 859  TSPIRVKV-EPSH--DASKVKAEGPGLNRTGVELGKPTHFTVNAKTAGKGKLDVQFSGLA 915

Query: 2211 K----VKMDCQECPEG-YRVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNH 2375
            K      +D  +  +  Y V Y P+  G   +++ YGG  HI  SPF   V+        
Sbjct: 916  KGDAVRDVDIIDHHDNTYTVKYIPVQQGPVGVNVTYGGD-HIPKSPFSVGVS-------- 966

Query: 2376 SLHETSSVFVDSLTKTXXXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKA 2555
                                            SK+   GLG  K  VG+   FTV    A
Sbjct: 967  ---------------------------PSLDLSKIKVSGLG-DKVDVGKDQEFTVKSKGA 998

Query: 2556 GNN----MLLVGVHGPRTPCEEILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSP 2723
            G        +V   G   PC+  +   +G+    V ++ +++G Y + V +    +PGSP
Sbjct: 999  GGQGKVASKIVSPSGAAVPCK--VEPGLGADNSVVRFVPREEGPYEVEVTYDGVPVPGSP 1056

Query: 2724 Y 2726
            +
Sbjct: 1057 F 1057


>ref|NP_598841.1| filamin-B [Mus musculus].
          Length = 2591

 Score = 1292 bits (3344), Expect = 0.0
 Identities = 620/889 (69%), Positives = 741/889 (83%), Gaps = 5/889 (0%)
 Frame = +3

Query: 90   AQGGQQTWAPERPL-----VGVNGLDVTSLRPFDLVIPFTIKKGEITGEVRMPSGKVAQP 254
            A  G+ T   E P+     V V+ ++    +PFDLVIPF ++KGEITG V MPSGK A P
Sbjct: 1704 ATDGEVTAMEEAPVTEEAYVPVSDMNGLGFKPFDLVIPFAVRKGEITGTVHMPSGKKATP 1763

Query: 255  AITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFYVDYVNCGHVTAYGPGLSHG 434
             I DNKDGTVTVRYAP+E GLHEM I+Y   HIP SPLQFYV+Y N G V+AYGPGL +G
Sbjct: 1764 EIVDNKDGTVTVRYAPTEVGLHEMHIKYRGSHIPESPLQFYVNYPNSGSVSAYGPGLVYG 1823

Query: 435  VVNKPAVFTVNTKDAGEGGLSLAIEGPSKAEISCTDNQDGTCSVSYLPVLPGDYSILVKY 614
            V NK A FT+ T+DAGEGGL LAIEGPSKAEISC DN+DGTC+V+YLP LPGDYSILVKY
Sbjct: 1824 VANKTATFTIVTEDAGEGGLDLAIEGPSKAEISCIDNKDGTCTVTYLPTLPGDYSILVKY 1883

Query: 615  NEQHIPGSPFTARVTGDDSMRMSHLKVGSAADIPINISETDLSLLTATVVPPSGREEPCL 794
            N++HIPGSPFTA++T DD+ R S +K+GSAAD  ++ISETDLS LTA++  PSGR+EPCL
Sbjct: 1884 NDKHIPGSPFTAKIT-DDNRRCSQVKLGSAADFLLDISETDLSTLTASIKAPSGRDEPCL 1942

Query: 795  LKRLRNGHVGISFVPKETGEHLVHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLH 974
            LKRL N H+GISF+P+E GEHLV +KKNG HVA+SP+ +++ QSEIGDA R +V G+GL 
Sbjct: 1943 LKRLPNNHIGISFIPREVGEHLVSIKKNGNHVANSPVSIMVVQSEIGDARRAKVYGQGLS 2002

Query: 975  EGHTFEPAEFIIDTRDAGYGGLSLSIEGPSKVDINTEDLEDGTCRVTYCPTEPGNYIINI 1154
            EG TFE ++FI+DTRDAGYGG+SL++EGPSKVDI TEDLEDGTC+V+Y PT PG YI++ 
Sbjct: 2003 EGRTFEMSDFIVDTRDAGYGGISLAVEGPSKVDIQTEDLEDGTCKVSYFPTVPGVYIVST 2062

Query: 1155 KFADQHVPGSPFSVKVTGEGRVKESITRRQRAPSVANVGSHCDLSLKIPEISIQDMTAQV 1334
            KFAD+HVPGSPF+VK++GEGRV+ESITR  RAP+VA VGS CDL+LKIPEI+  DM+A V
Sbjct: 2063 KFADEHVPGSPFTVKISGEGRVRESITRTSRAPAVATVGSICDLNLKIPEINSSDMSAHV 2122

Query: 1335 TSPSGKSHEAEIVEGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGA 1514
            TSPSG   EAEIV    +++C+RFVP EMG+HTVSVKY+GQHV GSPFQFTVGPLGEGGA
Sbjct: 2123 TSPSGHVTEAEIVPMGKNSHCVRFVPQEMGVHTVSVKYRGQHVTGSPFQFTVGPLGEGGA 2182

Query: 1515 HKVRAGGPGLERAEAGVPAEFSIWTREAGAGGLAIAVEGPSKAEISFEDRKDGSCGVAYV 1694
            HKVRAGGPGLER EAG+PAEFSIWTREAGAGGL+IAVEGPSKAEI+F+D K+GSCGV+Y+
Sbjct: 2183 HKVRAGGPGLERGEAGIPAEFSIWTREAGAGGLSIAVEGPSKAEITFDDHKNGSCGVSYI 2242

Query: 1695 VQEPGDYEVSVKFNEEHIPDSPFVVPVASPSGDARRLTVSSLQESGLKVNQPASFAVSLN 1874
             QEPG+YEVS+KFN+EHIPDSP++VPV +PS DAR LTV SLQESGLKVNQPASFA+ LN
Sbjct: 2243 AQEPGNYEVSIKFNDEHIPDSPYLVPVIAPSDDARCLTVLSLQESGLKVNQPASFAIRLN 2302

Query: 1875 GAKGAIDAKVHSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKI 2054
            GAKG IDAKVHSPSGA+EEC+V+E++ DKYAVRFIP ENG++ IDVKFNG+H+ GSPFK+
Sbjct: 2303 GAKGKIDAKVHSPSGAVEECHVSELEPDKYAVRFIPHENGIHTIDVKFNGSHVVGSPFKV 2362

Query: 2055 RVGEPGHGGDPGLVSAYGAGLEGGVTGSPAEFIVNTSNAGAGALSVTIDGPSKVKMDCQE 2234
            RVGEPG  G+P LVSAYGAGLE G TG  +EF +NT+ AG G LSVTI+GPSKVKMDCQE
Sbjct: 2363 RVGEPGQAGNPALVSAYGAGLETGTTGIQSEFFINTTQAGPGTLSVTIEGPSKVKMDCQE 2422

Query: 2235 CPEGYRVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSVFVDSL 2414
             PEGY+V YTPMAPG+YLI +KYGGP HI  SPFKA+VTG RLVS  S +ETSS+ V+S+
Sbjct: 2423 IPEGYKVMYTPMAPGNYLIGVKYGGPNHISRSPFKAKVTGQRLVSPGSANETSSILVESV 2482

Query: 2415 TKTXXXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKAGNNMLLVGVHGPR 2594
            T++                SKV +KG GLSKA+VGQK SF VDCSKAG+NMLL+GVHGP 
Sbjct: 2483 TRSSTETCYSAIPKSSSDASKVTSKGAGLSKAFVGQKSSFLVDCSKAGSNMLLIGVHGPT 2542

Query: 2595 TPCEEILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLVP 2741
            TPCEE+ +KHVG + Y+V+Y++K++G+Y L VKWG+EHIPGSP+ V VP
Sbjct: 2543 TPCEEVSMKHVGKQQYNVTYVVKERGDYVLAVKWGEEHIPGSPFHVTVP 2591



 Score =  440 bits (1132), Expect = e-123
 Identities = 293/886 (33%), Positives = 429/886 (48%), Gaps = 29/886 (3%)
 Frame = +3

Query: 168  PFDLVIPFTIK-----KGEITGEVRMPSGKVAQPAITDNKDGTVTVRYAPSEAGLHEMDI 332
            P  L + F I      +G +  ++    GK  +  + DNKDGT  V Y P + G + + +
Sbjct: 1533 PASLPVEFAIDARDAGEGLLAVQITDQEGKPQRATVHDNKDGTYAVTYIPDKTGRYMIGV 1592

Query: 333  RYDNMHIPGSPLQFYVDYV-NCGHVTAYGPGLSHGVVNKPAV-FTVNTKDAGEGGLSLAI 506
             Y   +IP SP +       +     A GPG++  V     V F V+ K AG+G ++  I
Sbjct: 1593 TYGGDNIPLSPYRIRATQTGDASKCLATGPGIAPTVKTGEEVGFVVDAKTAGKGKVTCVI 1652

Query: 507  EGP--SKAEISCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARVTGDDSMRM 680
              P  ++AE    +N+DGT  + Y    PG Y I V++    IP SPFT   T  +   M
Sbjct: 1653 LTPDGTEAEADVIENEDGTYDIFYTAAKPGTYVIYVRFGGVDIPNSPFTVMATDGEVTAM 1712

Query: 681  SHLKVGSAADIPIN------ISETDLSL--------LTATVVPPSGREEPCLLKRLRNGH 818
                V   A +P++          DL +        +T TV  PSG++    +   ++G 
Sbjct: 1713 EEAPVTEEAYVPVSDMNGLGFKPFDLVIPFAVRKGEITGTVHMPSGKKATPEIVDNKDGT 1772

Query: 819  VGISFVPKETGEHLVHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEGHTFEPA 998
            V + + P E G H +H+K  G H+  SP+   ++    G  S     G GL  G   + A
Sbjct: 1773 VTVRYAPTEVGLHEMHIKYRGSHIPESPLQFYVNYPNSGSVS---AYGPGLVYGVANKTA 1829

Query: 999  EFIIDTRDAGYGGLSLSIEGPSKVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVP 1178
             F I T DAG GGL L+IEGPSK +I+  D +DGTC VTY PT PG+Y I +K+ D+H+P
Sbjct: 1830 TFTIVTEDAGEGGLDLAIEGPSKAEISCIDNKDGTCTVTYLPTLPGDYSILVKYNDKHIP 1889

Query: 1179 GSPFSVKVTGEGRVKESITRRQRAPSVANVGSHCDLSLKIPEISIQDMTAQVTSPSGKSH 1358
            GSPF+ K+T +           R  S   +GS  D  L I E  +  +TA + +PSG+  
Sbjct: 1890 GSPFTAKITDD----------NRRCSQVKLGSAADFLLDISETDLSTLTASIKAPSGRDE 1939

Query: 1359 EAEIVEGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGP 1538
               +    N+   I F+P E+G H VS+K  G HV  SP    V     G A + +  G 
Sbjct: 1940 PCLLKRLPNNHIGISFIPREVGEHLVSIKKNGNHVANSPVSIMVVQSEIGDARRAKVYGQ 1999

Query: 1539 GLERAEAGVPAEFSIWTREAGAGGLAIAVEGPSKAEISFEDRKDGSCGVAYVVQEPGDYE 1718
            GL        ++F + TR+AG GG+++AVEGPSK +I  ED +DG+C V+Y    PG Y 
Sbjct: 2000 GLSEGRTFEMSDFIVDTRDAGYGGISLAVEGPSKVDIQTEDLEDGTCKVSYFPTVPGVYI 2059

Query: 1719 VSVKFNEEHIPDSPFVVPVASPSGDARRLTVSSLQESGLKVNQPASFAVSLNGAKGA-ID 1895
            VS KF +EH+P SPF V ++        +T +S   +   V       + +     + + 
Sbjct: 2060 VSTKFADEHVPGSPFTVKISGEGRVRESITRTSRAPAVATVGSICDLNLKIPEINSSDMS 2119

Query: 1896 AKVHSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGH 2075
            A V SPSG + E  +  + ++ + VRF+P+E GV+ + VK+ G H+ GSPF+  VG  G 
Sbjct: 2120 AHVTSPSGHVTEAEIVPMGKNSHCVRFVPQEMGVHTVSVKYRGQHVTGSPFQFTVGPLGE 2179

Query: 2076 GGDPGLVSAYGAGLEGGVTGSPAEFIVNTSNAGAGALSVTIDGPSKVKMDCQECPEG-YR 2252
            GG    V A G GLE G  G PAEF + T  AGAG LS+ ++GPSK ++   +   G   
Sbjct: 2180 GG-AHKVRAGGPGLERGEAGIPAEFSIWTREAGAGGLSIAVEGPSKAEITFDDHKNGSCG 2238

Query: 2253 VTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTG----HRLVSNHSLHETSSVFVDSLTK 2420
            V+Y    PG+Y +SIK+    HI  SP+   V       R ++  SL E+          
Sbjct: 2239 VSYIAQEPGNYEVSIKFNDE-HIPDSPYLVPVIAPSDDARCLTVLSLQES---------- 2287

Query: 2421 TXXXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKAGNNMLLVGVHGPRTP 2600
                                     GL    V Q  SF +  + A    +   VH P   
Sbjct: 2288 -------------------------GLK---VNQPASFAIRLNGA-KGKIDAKVHSPSGA 2318

Query: 2601 CEEILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLV 2738
             EE  V  +    Y+V ++  + G +T+ VK+   H+ GSP++V V
Sbjct: 2319 VEECHVSELEPDKYAVRFIPHENGIHTIDVKFNGSHVVGSPFKVRV 2364



 Score =  347 bits (891), Expect = 2e-95
 Identities = 271/889 (30%), Positives = 424/889 (47%), Gaps = 40/889 (4%)
 Frame = +3

Query: 204  GEITGEVRMPSGKVAQPAITDNKDGTV-TVRYAPSEAGLHEMDIRYDNMHIPGSPLQFYV 380
            G+I  EV  P GK +   + +++   V    Y P + G H + + +    IP SP    +
Sbjct: 387  GDIGIEVEDPQGKNSVELLVEDRGNQVYRCVYKPVQPGPHVVKVSFAGDAIPKSPFGVQI 446

Query: 381  -DYVNCGHVTAYGPGLS-HGV-VNKPAVFTVNTKDAGEGGLSLAIEGPSKAE--ISCTDN 545
             +  N     A G GL   GV + + A F V+TK AG G L + ++GP   E  +     
Sbjct: 447  GEACNPNACRASGRGLQPKGVRIRETADFKVDTKAAGSGELGVTVKGPKGLEELVKQKGF 506

Query: 546  QDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARVTGDDSMRMSHLK--------VGS 701
             DG  S  Y P  PG YS+ V +   HIP SPF  +V  +  M+             VG 
Sbjct: 507  LDGVYSFEYYPSTPGKYSVAVTWGGHHIPKSPFEVQVGPEAGMQKVRAWGPGLHGGIVGR 566

Query: 702  AADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNG 881
            +AD  +    +++  L   +  PS  +         +G   + + PKE GE+ VH+  + 
Sbjct: 567  SADFVVESIGSEVGTLGFAIEGPS--QAKIEYDDQNDGSCDVKYWPKEPGEYAVHIMCDD 624

Query: 882  QHVASSPIPVVISQSEIGDASR--VRVSGRGLHE-GHTFE-PAEFIIDTRDAGYGGLS-L 1046
            + +  SP    I  +  GD +   V+  G GL + G T   PAEFI+D +DAG   L  L
Sbjct: 625  EDIKDSPYMAFIHPAT-GDYNPDLVQAYGPGLEKSGCTINNPAEFIVDPKDAGSAPLKIL 683

Query: 1047 SIEGPSK-VDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTGEG--- 1214
            + +G  + +DI  +   DGT   +Y P +   + I + +   ++P SP+ V + G+G   
Sbjct: 684  AQDGEGQPIDIQMKSRMDGTYACSYTPLKAIKHTIAVVWGGVNIPHSPYRVNI-GQGSHP 742

Query: 1215 -RVKESITRRQRAPSVANVGSHCDLSLKIPEISIQDMT------AQVTSPSGKSHEAEIV 1373
             +VK      +R+   AN  +H   ++   E    D++      A+V S   +  + +I+
Sbjct: 743  QKVKVFGPGVERSGLKANEPTH--FTVDCTEAGEGDVSVGIKCDARVLSDDEEDVDFDII 800

Query: 1374 EGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLERA 1553
               N T+ +++VP   G +T+ V +  Q +P SPF+  V P  +  A KV+A GPGL +A
Sbjct: 801  HNANDTFTVKYVPPAPGRYTIKVLFASQEIPASPFRVKVDPSHD--ASKVKAEGPGLSKA 858

Query: 1554 --EAGVPAEFSIWTREAGAGGLAIAVEGPSKAE----ISFEDRKDGSCGVAYVVQEPGDY 1715
              E G P  F++ T+ AG   L +    P   E    +   D  D S  V Y   + G+ 
Sbjct: 859  GVENGKPTHFTVHTKGAGKAPLNVQFSSPLPGEAVKDLDIIDNYDYSHTVKYTPTQQGNM 918

Query: 1716 EVSVKFNEEHIPDSPFVVPVASPSGDARRLTVSSLQESGLKVNQPASFAVSLNGA--KGA 1889
            +V V +  + IP SPF V VA+P  D  ++ ++ L E+ ++V +   FA+  NGA  +G 
Sbjct: 919  QVLVTYGGDPIPKSPFTVGVAAPL-DLSKIKINGL-ENRVEVGKDQEFAIDTNGAGGQGK 976

Query: 1890 IDAKVHSPSGALEECYVTEI-DQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGE 2066
            +D  + SPS  +  C V  +  ++    +FIPRE G++ +DV ++G  +PGSP+ +    
Sbjct: 977  LDVTILSPSRKVVPCLVAPVAGRECSTAKFIPREEGLFAVDVTYDGHPVPGSPYTVEASL 1036

Query: 2067 PGHGGDPGLVSAYGAGLEGGVTGSPAEFIVNTSNAGAGALSVTIDGPSKVKMDCQECPEG 2246
            P    DP  V A+G GLEGG+ G PAEF ++T  AG G L +T++GP + K++C +  +G
Sbjct: 1037 PP---DPTKVKAHGPGLEGGLVGKPAEFTIDTKGAGTGGLGLTVEGPCEAKIECSDNGDG 1093

Query: 2247 Y-RVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSVFVDSLTKT 2423
               V+Y P  PG Y ++I +    HI GSPFKA +                         
Sbjct: 1094 TCSVSYLPTKPGEYFVNILFE-EVHIPGSPFKADIE------------------------ 1128

Query: 2424 XXXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKAGNNMLLVGVHGPRTPC 2603
                            SKV+A G GL    VG+ G   VDCS+AG   L +         
Sbjct: 1129 -----------MPFDPSKVVASGPGLEHGKVGEPGILCVDCSEAGPGTLGLEAVSDSGAK 1177

Query: 2604 EEILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLVP*AL 2750
             E+ +++     Y+V+Y+    G YTL +K+G E +P  P  V V  A+
Sbjct: 1178 AEVSIQNNKDGTYAVTYVPLTAGMYTLTMKYGGELVPHFPAWVKVEPAI 1226



 Score =  325 bits (832), Expect = 2e-88
 Identities = 239/774 (30%), Positives = 368/774 (47%), Gaps = 39/774 (5%)
 Frame = +3

Query: 201  KGEITGEVRMPSGKVAQPAITDNKDGTV--TVRYAPSEAGLHEMDIRYDNMHIPGSPLQF 374
            +G++   +  PS KV  P +     G    T ++ P E GL  +D+ YD   +PGSP   
Sbjct: 974  QGKLDVTILSPSRKVV-PCLVAPVAGRECSTAKFIPREEGLFAVDVTYDGHPVPGSPYTV 1032

Query: 375  YVDYV-NCGHVTAYGPGLSHGVVNKPAVFTVNTKDAGEGGLSLAIEGPSKAEISCTDNQD 551
                  +   V A+GPGL  G+V KPA FT++TK AG GGL L +EGP +A+I C+DN D
Sbjct: 1033 EASLPPDPTKVKAHGPGLEGGLVGKPAEFTIDTKGAGTGGLGLTVEGPCEAKIECSDNGD 1092

Query: 552  GTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARV--------TGDDSMRMSHLKVGSAA 707
            GTCSVSYLP  PG+Y + + + E HIPGSPF A +               + H KVG   
Sbjct: 1093 GTCSVSYLPTKPGEYFVNILFEEVHIPGSPFKADIEMPFDPSKVVASGPGLEHGKVGEPG 1152

Query: 708  DIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNGQH 887
             + ++ SE     L    V  SG +    ++  ++G   +++VP   G + + +K  G+ 
Sbjct: 1153 ILCVDCSEAGPGTLGLEAVSDSGAKAEVSIQNNKDGTYAVTYVPLTAGMYTLTMKYGGEL 1212

Query: 888  VASSPIPVVISQSEIGDASRVRVSGRGLHEGHTFEPA--EFIIDTR---DAGYGGLSLSI 1052
            V   P  V +  +   D S ++  G G+     F  A  +F +D+R     G   +   I
Sbjct: 1213 VPHFPAWVKVEPAI--DTSGIKAFGPGIEGKDVFREATTDFTVDSRPLTQVGGDHIKAQI 1270

Query: 1053 EGPS--KVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVT------- 1205
              PS    +   +D  DGT +V Y P E G +++ + + D  +P SPF V VT       
Sbjct: 1271 TNPSGASTECFVKDNADGTYQVEYTPFEKGFHVVEVTYDDVPIPNSPFKVAVTEGCQPSR 1330

Query: 1206 ----GEGRVKESITRRQRAPSVANVGSHCDLSLKIPEISIQDMTAQVTSPSGKSHEAEIV 1373
                G G +KE+ T +    +V   G+            I  +   V  PS    +    
Sbjct: 1331 VHAQGPG-LKEAFTNKSNVFTVVTRGA-----------GIGGLGITVEGPS--ESKINCR 1376

Query: 1374 EGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLER- 1550
            + ++ +    ++P   G + V++ Y G H+PGSPF+     + +    KV+  GPGL   
Sbjct: 1377 DNKDGSCSAEYIPFAPGDYDVNITYGGVHIPGSPFRVPSKDVVD--PSKVKIAGPGLSSC 1434

Query: 1551 AEAGVPAEFSIWTREAGAGGLAIAVEGPS--KAEISFEDRKDGSCGVAYVVQEPGDYEVS 1724
              A +P  F++ + +AG   L + V GP      ++  D  DG+  V Y   + G Y VS
Sbjct: 1435 VRACIPQSFTVDSSKAGLAPLEVRVLGPRGLVEPVNVVDNGDGTHTVTYTPSQEGPYIVS 1494

Query: 1725 VKFNEEHIPDSPFVVPVASPSGDARRLTVS--SLQESGLKVNQPASFAVSLNGA-KGAID 1895
            VK+ +E IP SPF V V  P+ DA ++T S   L   G+  + P  FA+    A +G + 
Sbjct: 1495 VKYADEEIPRSPFKVKVL-PTYDASKVTASGPGLSAYGVPASLPVEFAIDARDAGEGLLA 1553

Query: 1896 AKVHSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGH 2075
             ++    G  +   V +     YAV +IP + G Y+I V + G +IP SP++IR  +   
Sbjct: 1554 VQITDQEGKPQRATVHDNKDGTYAVTYIPDKTGRYMIGVTYGGDNIPLSPYRIRATQT-- 1611

Query: 2076 GGDPGLVSAYGAGLEGGV-TGSPAEFIVNTSNAGAGALSVTIDGP--SKVKMDCQECPEG 2246
             GD     A G G+   V TG    F+V+   AG G ++  I  P  ++ + D  E  +G
Sbjct: 1612 -GDASKCLATGPGIAPTVKTGEEVGFVVDAKTAGKGKVTCVILTPDGTEAEADVIENEDG 1670

Query: 2247 -YRVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSVFV 2405
             Y + YT   PG+Y+I +++GG   I  SPF    T   + +      T   +V
Sbjct: 1671 TYDIFYTAAKPGTYVIYVRFGG-VDIPNSPFTVMATDGEVTAMEEAPVTEEAYV 1723



 Score =  296 bits (758), Expect = 7e-80
 Identities = 251/902 (27%), Positives = 387/902 (42%), Gaps = 59/902 (6%)
 Frame = +3

Query: 201  KGEITGEVRMPSGKVAQPAIT--DNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQF 374
            +G++   V  P G   +  +T   +K+ T +V Y P   GLH++ + +   HI  SP + 
Sbjct: 286  QGDVMVFVEDPEGNKEEARVTPDSDKNKTYSVEYLPKVTGLHKVIVLFAGQHISKSPFEV 345

Query: 375  YVDYV--NCGHVTAYGPGL--SHGVVNKPAVFTVNTKDAGEGGLSLAIEGP---SKAEIS 533
             VD    +   VTA GPGL  +  + NKP  F + T  AG G + + +E P   +  E+ 
Sbjct: 346  NVDKAQGDASKVTAKGPGLETTGNIANKPTYFDIYTAGAGVGDIGIEVEDPQGKNSVELL 405

Query: 534  CTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARV----------TGDDSMRMS 683
              D  +      Y PV PG + + V +    IP SPF  ++               ++  
Sbjct: 406  VEDRGNQVYRCVYKPVQPGPHVVKVSFAGDAIPKSPFGVQIGEACNPNACRASGRGLQPK 465

Query: 684  HLKVGSAADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLV 863
             +++   AD  ++        L  TV  P G EE    K   +G     + P   G++ V
Sbjct: 466  GVRIRETADFKVDTKAAGSGELGVTVKGPKGLEELVKQKGFLDGVYSFEYYPSTPGKYSV 525

Query: 864  HVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEGHTFEPAEFIIDTRDAGYGGLS 1043
             V   G H+  SP  V +         +VR  G GLH G     A+F++++  +  G L 
Sbjct: 526  AVTWGGHHIPKSPFEVQVGPE--AGMQKVRAWGPGLHGGIVGRSADFVVESIGSEVGTLG 583

Query: 1044 LSIEGPSKVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFS---------- 1193
             +IEGPS+  I  +D  DG+C V Y P EPG Y ++I   D+ +  SP+           
Sbjct: 584  FAIEGPSQAKIEYDDQNDGSCDVKYWPKEPGEYAVHIMCDDEDIKDSPYMAFIHPATGDY 643

Query: 1194 ----VKVTGEGRVKESITRRQRAPSVANVGSHCDLSLKIPEISIQDMTAQVTSPSGKSHE 1361
                V+  G G  K   T    A  + +        LK   I  QD   Q      KS  
Sbjct: 644  NPDLVQAYGPGLEKSGCTINNPAEFIVDPKDAGSAPLK---ILAQDGEGQPIDIQMKSR- 699

Query: 1362 AEIVEGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAH--KVRAGG 1535
               ++G   TY   + P +   HT++V + G ++P SP++  +G     G+H  KV+  G
Sbjct: 700  ---MDG---TYACSYTPLKAIKHTIAVVWGGVNIPHSPYRVNIGQ----GSHPQKVKVFG 749

Query: 1536 PGLERA--EAGVPAEFSIWTREAGAGGLAIAVEGPSKAEISFEDRKD----------GSC 1679
            PG+ER+  +A  P  F++   EAG G +++ ++    A +  +D +D           + 
Sbjct: 750  PGVERSGLKANEPTHFTVDCTEAGEGDVSVGIK--CDARVLSDDEEDVDFDIIHNANDTF 807

Query: 1680 GVAYVVQEPGDYEVSVKFNEEHIPDSPFVVPVASPSGDARRLTVS--SLQESGLKVNQPA 1853
             V YV   PG Y + V F  + IP SPF V V  PS DA ++      L ++G++  +P 
Sbjct: 808  TVKYVPPAPGRYTIKVLFASQEIPASPFRVKV-DPSHDASKVKAEGPGLSKAGVENGKPT 866

Query: 1854 SFAVSLNGA-KGAIDAKVHS--PSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNG 2024
             F V   GA K  ++ +  S  P  A+++  + +     + V++ P + G   + V + G
Sbjct: 867  HFTVHTKGAGKAPLNVQFSSPLPGEAVKDLDIIDNYDYSHTVKYTPTQQGNMQVLVTYGG 926

Query: 2025 THIPGSPFKIRVGEPGHGGDPGLVSAYGAGLEGGV-TGSPAEFIVNTSNAGA-GALSVTI 2198
              IP SPF + V  P       L      GLE  V  G   EF ++T+ AG  G L VTI
Sbjct: 927  DPIPKSPFTVGVAAP-----LDLSKIKINGLENRVEVGKDQEFAIDTNGAGGQGKLDVTI 981

Query: 2199 DGPSKVKMDCQECPEGYR----VTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLV 2366
              PS+  + C   P   R      + P   G + + + Y G + + GSP+    +     
Sbjct: 982  LSPSRKVVPCLVAPVAGRECSTAKFIPREEGLFAVDVTYDG-HPVPGSPYTVEAS----- 1035

Query: 2367 SNHSLHETSSVFVDSLTKTXXXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDC 2546
                                               +KV A G GL    VG+   FT+D 
Sbjct: 1036 ------------------------------LPPDPTKVKAHGPGLEGGLVGKPAEFTIDT 1065

Query: 2547 SKAGNNMLLVGVHGPRTPCE-EILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSP 2723
              AG   L + V G   PCE +I     G    SVSYL    GEY + + + + HIPGSP
Sbjct: 1066 KGAGTGGLGLTVEG---PCEAKIECSDNGDGTCSVSYLPTKPGEYFVNILFEEVHIPGSP 1122

Query: 2724 YR 2729
            ++
Sbjct: 1123 FK 1124



 Score =  289 bits (740), Expect = 8e-78
 Identities = 253/879 (28%), Positives = 397/879 (45%), Gaps = 57/879 (6%)
 Frame = +3

Query: 273  DGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFYVDYVNCGH------VTAYGPGLSHG 434
            DGT    Y P +A  H + + +  ++IP SP +     VN G       V  +GPG+   
Sbjct: 701  DGTYACSYTPLKAIKHTIAVVWGGVNIPHSPYR-----VNIGQGSHPQKVKVFGPGVERS 755

Query: 435  VV--NKPAVFTVNTKDAGEGGLSLAIEGPSKA--------EISCTDNQDGTCSVSYLPVL 584
             +  N+P  FTV+  +AGEG +S+ I+  ++         +     N + T +V Y+P  
Sbjct: 756  GLKANEPTHFTVDCTEAGEGDVSVGIKCDARVLSDDEEDVDFDIIHNANDTFTVKYVPPA 815

Query: 585  PGDYSILVKYNEQHIPGSPFTARV------------------TGDDSMRMSHLKVGS--A 704
            PG Y+I V +  Q IP SPF  +V                   G ++ + +H  V +  A
Sbjct: 816  PGRYTIKVLFASQEIPASPFRVKVDPSHDASKVKAEGPGLSKAGVENGKPTHFTVHTKGA 875

Query: 705  ADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNGQ 884
               P+N+         ++ +P    ++  ++      H  + + P + G   V V   G 
Sbjct: 876  GKAPLNVQ-------FSSPLPGEAVKDLDIIDNYDYSHT-VKYTPTQQGNMQVLVTYGGD 927

Query: 885  HVASSPIPVVISQSEIGDASRVRVSGRGLHEGHTFEPAEFIIDTRDAG-YGGLSLSIEGP 1061
             +  SP  V ++     D S+++++G   +     +  EF IDT  AG  G L ++I  P
Sbjct: 928  PIPKSPFTVGVAAPL--DLSKIKINGLE-NRVEVGKDQEFAIDTNGAGGQGKLDVTILSP 984

Query: 1062 SK--VDINTEDLEDGTCRVT-YCPTEPGNYIINIKFADQHVPGSPFSVKVTGEGRVKESI 1232
            S+  V      +    C    + P E G + +++ +    VPGSP++V    E  +    
Sbjct: 985  SRKVVPCLVAPVAGRECSTAKFIPREEGLFAVDVTYDGHPVPGSPYTV----EASLPPDP 1040

Query: 1233 TR-RQRAPSVAN--VGSHCDLSLKIPEISIQDMTAQVTSPSGKSHEAEIVEGENH--TYC 1397
            T+ +   P +    VG   + ++         +   V  P     EA+I   +N   T  
Sbjct: 1041 TKVKAHGPGLEGGLVGKPAEFTIDTKGAGTGGLGLTVEGPC----EAKIECSDNGDGTCS 1096

Query: 1398 IRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLERAEAGVPAEF 1577
            + ++P + G + V++ ++  H+PGSPF+  +    +    KV A GPGLE  + G P   
Sbjct: 1097 VSYLPTKPGEYFVNILFEEVHIPGSPFKADIEMPFDPS--KVVASGPGLEHGKVGEPGIL 1154

Query: 1578 SIWTREAGAG--GLAIAVEGPSKAEISFEDRKDGSCGVAYVVQEPGDYEVSVKFNEEHIP 1751
             +   EAG G  GL    +  +KAE+S ++ KDG+  V YV    G Y +++K+  E +P
Sbjct: 1155 CVDCSEAGPGTLGLEAVSDSGAKAEVSIQNNKDGTYAVTYVPLTAGMYTLTMKYGGELVP 1214

Query: 1752 DSPFVVPVASPSGDARRLTVSSLQESGLKVNQPASFAVSLNGAK------GAIDAKVHSP 1913
              P  V V  P+ D   +        G  V + A+   +++           I A++ +P
Sbjct: 1215 HFPAWVKV-EPAIDTSGIKAFGPGIEGKDVFREATTDFTVDSRPLTQVGGDHIKAQITNP 1273

Query: 1914 SGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPGL 2093
            SGA  EC+V +     Y V + P E G ++++V ++   IP SPFK+ V E   G  P  
Sbjct: 1274 SGASTECFVKDNADGTYQVEYTPFEKGFHVVEVTYDDVPIPNSPFKVAVTE---GCQPSR 1330

Query: 2094 VSAYGAGLEGGVTGSPAEFIVNTSNAGAGALSVTIDGPSKVKMDCQECPEGY-RVTYTPM 2270
            V A G GL+   T     F V T  AG G L +T++GPS+ K++C++  +G     Y P 
Sbjct: 1331 VHAQGPGLKEAFTNKSNVFTVVTRGAGIGGLGITVEGPSESKINCRDNKDGSCSAEYIPF 1390

Query: 2271 APGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSVFVDSLTKTXXXXXXXXX 2450
            APG Y ++I YGG  HI GSPF+                 S   VD              
Sbjct: 1391 APGDYDVNITYGG-VHIPGSPFRV---------------PSKDVVDP------------- 1421

Query: 2451 XXXXXXXSKVLAKGLGLS---KAYVGQKGSFTVDCSKAGNNMLLVGVHGPRTPCEEILVK 2621
                   SKV   G GLS   +A + Q  SFTVD SKAG   L V V GPR   E + V 
Sbjct: 1422 -------SKVKIAGPGLSSCVRACIPQ--SFTVDSSKAGLAPLEVRVLGPRGLVEPVNVV 1472

Query: 2622 HVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLV 2738
              G   ++V+Y    +G Y + VK+ DE IP SP++V V
Sbjct: 1473 DNGDGTHTVTYTPSQEGPYIVSVKYADEEIPRSPFKVKV 1511



 Score =  283 bits (725), Expect = 4e-76
 Identities = 247/886 (27%), Positives = 383/886 (43%), Gaps = 41/886 (4%)
 Frame = +3

Query: 204  GEITGEVRMPSGKVAQPAITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFYVD 383
            GE+   V+ P G           DG  +  Y PS  G + + + +   HIP SP +  V 
Sbjct: 485  GELGVTVKGPKGLEELVKQKGFLDGVYSFEYYPSTPGKYSVAVTWGGHHIPKSPFEVQVG 544

Query: 384  -YVNCGHVTAYGPGLSHGVVNKPAVFTVNTKDAGEGGLSLAIEGPSKAEISCTDNQDGTC 560
                   V A+GPGL  G+V + A F V +  +  G L  AIEGPS+A+I   D  DG+C
Sbjct: 545  PEAGMQKVRAWGPGLHGGIVGRSADFVVESIGSEVGTLGFAIEGPSQAKIEYDDQNDGSC 604

Query: 561  SVSYLPVLPGDYSILVKYNEQHIPGSPFTARV---TGD----------DSMRMSHLKVGS 701
             V Y P  PG+Y++ +  +++ I  SP+ A +   TGD            +  S   + +
Sbjct: 605  DVKYWPKEPGEYAVHIMCDDEDIKDSPYMAFIHPATGDYNPDLVQAYGPGLEKSGCTINN 664

Query: 702  AADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNG 881
             A+  ++  +   + L        G+     +K   +G    S+ P +  +H + V   G
Sbjct: 665  PAEFIVDPKDAGSAPLKILAQDGEGQPIDIQMKSRMDGTYACSYTPLKAIKHTIAVVWGG 724

Query: 882  QHVASSPIPVVISQSEIGDASRVRVSGRGLHEG--HTFEPAEFIIDTRDAGYGGLSLSIE 1055
             ++  SP  V I Q       +V+V G G+        EP  F +D  +AG G +S+ I+
Sbjct: 725  VNIPHSPYRVNIGQG--SHPQKVKVFGPGVERSGLKANEPTHFTVDCTEAGEGDVSVGIK 782

Query: 1056 GPSKV-DINTEDLE-------DGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVT-- 1205
              ++V   + ED++       + T  V Y P  PG Y I + FA Q +P SPF VKV   
Sbjct: 783  CDARVLSDDEEDVDFDIIHNANDTFTVKYVPPAPGRYTIKVLFASQEIPASPFRVKVDPS 842

Query: 1206 -GEGRVKESITRRQRAPSVANVGSHCDLSLKIPEISIQDMTAQVTSPSGKSHEAEIVEGE 1382
                +VK       +A       +H  +  K    +  ++      P     + +I++  
Sbjct: 843  HDASKVKAEGPGLSKAGVENGKPTHFTVHTKGAGKAPLNVQFSSPLPGEAVKDLDIIDNY 902

Query: 1383 NHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLE-RAEA 1559
            ++++ +++ P + G   V V Y G  +P SP  FTVG        K++    GLE R E 
Sbjct: 903  DYSHTVKYTPTQQGNMQVLVTYGGDPIPKSP--FTVGVAAPLDLSKIKIN--GLENRVEV 958

Query: 1560 GVPAEFSIWTREAGA-GGLAIAVEGPSKAEIS--FEDRKDGSCGVA-YVVQEPGDYEVSV 1727
            G   EF+I T  AG  G L + +  PS+  +           C  A ++ +E G + V V
Sbjct: 959  GKDQEFAIDTNGAGGQGKLDVTILSPSRKVVPCLVAPVAGRECSTAKFIPREEGLFAVDV 1018

Query: 1728 KFNEEHIPDSPFVVPVASPSGDARRLTVSSLQESGLKVNQPASFAVSLNGA-KGAIDAKV 1904
             ++   +P SP+ V  + P    +        E GL V +PA F +   GA  G +   V
Sbjct: 1019 TYDGHPVPGSPYTVEASLPPDPTKVKAHGPGLEGGL-VGKPAEFTIDTKGAGTGGLGLTV 1077

Query: 1905 HSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGD 2084
              P  A  EC  ++      +V ++P + G Y +++ F   HIPGSPFK  +  P    D
Sbjct: 1078 EGPCEAKIEC--SDNGDGTCSVSYLPTKPGEYFVNILFEEVHIPGSPFKADIEMP---FD 1132

Query: 2085 PGLVSAYGAGLEGGVTGSPAEFIVNTSNAGAGALSV--TIDGPSKVKMDCQECPEG-YRV 2255
            P  V A G GLE G  G P    V+ S AG G L +    D  +K ++  Q   +G Y V
Sbjct: 1133 PSKVVASGPGLEHGKVGEPGILCVDCSEAGPGTLGLEAVSDSGAKAEVSIQNNKDGTYAV 1192

Query: 2256 TYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSVFVDSLTKTXXXX 2435
            TY P+  G Y +++KYGG                 LV     H  + V V+    T    
Sbjct: 1193 TYVPLTAGMYTLTMKYGG----------------ELVP----HFPAWVKVEPAIDT---- 1228

Query: 2436 XXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGS--FTVD---CSKAGNNMLLVGVHGPRTP 2600
                        S + A G G+    V ++ +  FTVD    ++ G + +   +  P   
Sbjct: 1229 ------------SGIKAFGPGIEGKDVFREATTDFTVDSRPLTQVGGDHIKAQITNPSGA 1276

Query: 2601 CEEILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLV 2738
              E  VK      Y V Y   +KG + + V + D  IP SP++V V
Sbjct: 1277 STECFVKDNADGTYQVEYTPFEKGFHVVEVTYDDVPIPNSPFKVAV 1322



 Score =  231 bits (589), Expect = 3e-60
 Identities = 229/840 (27%), Positives = 365/840 (43%), Gaps = 47/840 (5%)
 Frame = +3

Query: 354  PGSPLQFYVDYVNCGHVTAYGPGL--SHGVVNKPAVFTVNTKDAGEGGLSLAIEGP---- 515
            PG+PL+     +N     AYG G+  +  +V +PA FTV+T  AG+G + + +E P    
Sbjct: 244  PGAPLK---PKLNPKKARAYGRGIEPTGNMVKQPAKFTVDTISAGQGDVMVFVEDPEGNK 300

Query: 516  SKAEISCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARVTGDDSMRMSHLKV 695
             +A ++   +++ T SV YLP + G + ++V +  QHI  SPF   V             
Sbjct: 301  EEARVTPDSDKNKTYSVEYLPKVTGLHKVIVLFAGQHISKSPFEVNVDKAQGDASKVTAK 360

Query: 696  GSAADIPINISE--TDLSLLTA---------TVVPPSGREEPCLLKRLRNGHV-GISFVP 839
            G   +   NI+   T   + TA          V  P G+    LL   R   V    + P
Sbjct: 361  GPGLETTGNIANKPTYFDIYTAGAGVGDIGIEVEDPQGKNSVELLVEDRGNQVYRCVYKP 420

Query: 840  KETGEHLVHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEG--HTFEPAEFIID 1013
             + G H+V V   G  +  SP  V I   E  + +  R SGRGL        E A+F +D
Sbjct: 421  VQPGPHVVKVSFAGDAIPKSPFGVQI--GEACNPNACRASGRGLQPKGVRIRETADFKVD 478

Query: 1014 TRDAGYGGLSLSIEGPSKVD--INTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSP 1187
            T+ AG G L ++++GP  ++  +  +   DG     Y P+ PG Y + + +   H+P SP
Sbjct: 479  TKAAGSGELGVTVKGPKGLEELVKQKGFLDGVYSFEYYPSTPGKYSVAVTWGGHHIPKSP 538

Query: 1188 FSVKVTGEGRVKESITRRQRAPSVAN--VGSHCDLSLKIPEISIQDMTAQVTSPSGKSHE 1361
            F V+V  E  +++    R   P +    VG   D  ++     +  +   +  PS    E
Sbjct: 539  FEVQVGPEAGMQKV---RAWGPGLHGGIVGRSADFVVESIGSEVGTLGFAIEGPSQAKIE 595

Query: 1362 AEIVEGENHTYC-IRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGP-LGEGGAHKVRAGG 1535
                + +N   C +++ P E G + V +    + +  SP+   + P  G+     V+A G
Sbjct: 596  ---YDDQNDGSCDVKYWPKEPGEYAVHIMCDDEDIKDSPYMAFIHPATGDYNPDLVQAYG 652

Query: 1536 PGLERAEAGV--PAEFSIWTREAGAGGLAI-AVEGPSK-AEISFEDRKDGSCGVAYVVQE 1703
            PGLE++   +  PAEF +  ++AG+  L I A +G  +  +I  + R DG+   +Y   +
Sbjct: 653  PGLEKSGCTINNPAEFIVDPKDAGSAPLKILAQDGEGQPIDIQMKSRMDGTYACSYTPLK 712

Query: 1704 PGDYEVSVKFNEEHIPDSPFVVPVASPSGDAR-RLTVSSLQESGLKVNQPASFAVSLNGA 1880
               + ++V +   +IP SP+ V +   S   + ++    ++ SGLK N+P  F V    A
Sbjct: 713  AIKHTIAVVWGGVNIPHSPYRVNIGQGSHPQKVKVFGPGVERSGLKANEPTHFTVDCTEA 772

Query: 1881 -KGAI------DAKVHSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPG 2039
             +G +      DA+V S      +  +     D + V+++P   G Y I V F    IP 
Sbjct: 773  GEGDVSVGIKCDARVLSDDEEDVDFDIIHNANDTFTVKYVPPAPGRYTIKVLFASQEIPA 832

Query: 2040 SPFKIRVGEPGHGGDPGLVSAYGAGLE--GGVTGSPAEFIVNTSNAGAGALSVTIDGP-- 2207
            SPF+++V +P H  D   V A G GL   G   G P  F V+T  AG   L+V    P  
Sbjct: 833  SPFRVKV-DPSH--DASKVKAEGPGLSKAGVENGKPTHFTVHTKGAGKAPLNVQFSSPLP 889

Query: 2208 -SKVK-MD-CQECPEGYRVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHS 2378
               VK +D        + V YTP   G+  + + YGG   I  SPF   V          
Sbjct: 890  GEAVKDLDIIDNYDYSHTVKYTPTQQGNMQVLVTYGGD-PIPKSPFTVGVAA-------- 940

Query: 2379 LHETSSVFVDSLTKTXXXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKA- 2555
                                           SK+   GL  ++  VG+   F +D + A 
Sbjct: 941  ---------------------------PLDLSKIKINGLE-NRVEVGKDQEFAIDTNGAG 972

Query: 2556 GNNMLLVGVHGPRTPCEEILVKHVGSRLYSVS-YLLKDKGEYTLVVKWGDEHIPGSPYRV 2732
            G   L V +  P       LV  V  R  S + ++ +++G + + V +    +PGSPY V
Sbjct: 973  GQGKLDVTILSPSRKVVPCLVAPVAGRECSTAKFIPREEGLFAVDVTYDGHPVPGSPYTV 1032


>ref|NP_001074654.1| filamin-C [Mus musculus].
          Length = 2726

 Score =  798 bits (2061), Expect = 0.0
 Identities = 441/856 (51%), Positives = 559/856 (65%), Gaps = 24/856 (2%)
 Frame = +3

Query: 246  AQPAITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFYVDYVNCGHVTAYGPGL 425
            A+    DNKDGT TV Y P+  G + + +R+D+ HIPGSP    +   +    +    G 
Sbjct: 1903 AEITCKDNKDGTCTVSYLPTAPGDYSIIVRFDDKHIPGSPFTAKITGDDSMRTSQLNVGT 1962

Query: 426  SHGVVNKPAVFTVNTKDAGEGGLSLAIEGPSKAEISCTDNQ--DGTCSVSYLPVLPGDYS 599
            S  V  K     +   D  +  L+ +I  PS  E  C   +  +    +S+ P   G++ 
Sbjct: 1963 STDVSLK-----ITEGDLSQ--LTASIRAPSGNEEPCLLKRLPNRHIGISFTPKEVGEHV 2015

Query: 600  ILVKYNEQHIPGSPFTARV----TGDDSM------RMSHLKVGSAADIPINISETDLSLL 749
            + V+ + +H+  SPF   V     GD S        +S  +    A+  ++        L
Sbjct: 2016 VSVRKSGKHVTNSPFKILVGPSEIGDASKVRVWGKGLSEGQTFQVAEFIVDTRNAGYGGL 2075

Query: 750  TATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNGQHVASSPIPVVISQSE 929
              ++  PS  +  C  + + +G   +++ P E G +++++K   +HV  SP  V ++   
Sbjct: 2076 GLSIEGPSKVDINC--EDMEDGTCKVTYCPTEPGTYIINIKFADKHVPGSPFTVKVTGE- 2132

Query: 930  IGDASRVRVSGRGLHEGHTFEPAEFIIDTR---DAGYGGLSLSIEGPSKVDINTEDLEDG 1100
                 R++ S     +  +        D        +  +  + E  ++    +      
Sbjct: 2133 ----GRMKESITRRRQAPSIATIGSTCDLNLKIPGNWFQMVSAQERLTRTFTRSSHTYTR 2188

Query: 1101 TCRVTYCPTEPGNYIINIKFADQ-HVPGSPFSVKVTGEGRVKE------SITRRQRAPSV 1259
            T R     T  G     ++  +   V G PF   V G+   +E      SITR+Q     
Sbjct: 2189 TERTEISKTRGGETKREVRVEESTQVGGDPFPA-VFGDFLGRERLGSFGSITRQQEG--- 2244

Query: 1260 ANVGSHCDLSLKIPEISIQDMTAQVTSPSGKSHEAEIVEGENHTYCIRFVPAEMGMHTVS 1439
                          E S QDMTAQVTSPSGK+  AEIVEGE+  Y +RFVP EMG HTV+
Sbjct: 2245 --------------EASSQDMTAQVTSPSGKTEAAEIVEGEDSAYSVRFVPQEMGPHTVT 2290

Query: 1440 VKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLERAEAGVPAEFSIWTREAGAGGLAI 1619
            VKY+GQHVPGSPFQFTVGPLGEGGAHKVRAGG GLER  AGVPAEFSIWTREAGAGGL+I
Sbjct: 2291 VKYRGQHVPGSPFQFTVGPLGEGGAHKVRAGGTGLERGVAGVPAEFSIWTREAGAGGLSI 2350

Query: 1620 AVEGPSKAEISFEDRKDGSCGVAYVVQEPGDYEVSVKFNEEHIPDSPFVVPVASPSGDAR 1799
            AVEGPSKAEI+FEDRKDGSCGV+YVVQEPGDYEVS+KFN+EHIPDSPFVVPVAS S DAR
Sbjct: 2351 AVEGPSKAEIAFEDRKDGSCGVSYVVQEPGDYEVSIKFNDEHIPDSPFVVPVASLSDDAR 2410

Query: 1800 RLTVSSLQESGLKVNQPASFAVSLNGAKGAIDAKVHSPSGALEECYVTEIDQDKYAVRFI 1979
            RLTV+SLQE+GLKVNQPASFAV LNGA+G IDA+VH+PSGA+EECYV+E+D DK+ +RFI
Sbjct: 2411 RLTVTSLQETGLKVNQPASFAVQLNGARGVIDARVHTPSGAVEECYVSELDSDKHTIRFI 2470

Query: 1980 PRENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPGLVSAYGAGLEGGVTGSPAEFIVN 2159
            P ENGV+ IDVKFNG HIPGSPFKIRVGE    GDPGLVSAYG GLEGG TG  +EFIVN
Sbjct: 2471 PHENGVHSIDVKFNGAHIPGSPFKIRVGEQSQAGDPGLVSAYGPGLEGGTTGVSSEFIVN 2530

Query: 2160 TSNAGAGALSVTIDGPSKVKMDCQECPEGYRVTYTPMAPGSYLISIKYGGPYHIGGSPFK 2339
            T NAG+GALSVTIDGPSKV++DC+ECPEG+ VTYTPMAPG+YLI+IKYGGP HI GSPFK
Sbjct: 2531 TQNAGSGALSVTIDGPSKVQLDCRECPEGHVVTYTPMAPGNYLIAIKYGGPQHIVGSPFK 2590

Query: 2340 ARVTGHRLVSNHSLHETSSVFVDSLTK--TXXXXXXXXXXXXXXXXSKVLAKGLGLSKAY 2513
            A+VTG RL   HSLHETS+V V+++TK  +                SKV+ +G GLS+A+
Sbjct: 2591 AKVTGPRLSGGHSLHETSTVLVETVTKSSSSRGASYSSIPKFSSDASKVVTRGPGLSQAF 2650

Query: 2514 VGQKGSFTVDCSKAGNNMLLVGVHGPRTPCEEILVKHVGSRLYSVSYLLKDKGEYTLVVK 2693
            VGQK SFTVDCSKAG NM++VGVHGP+TPCEE+ VKH+G+R+Y+V+Y +K+KG+Y L+VK
Sbjct: 2651 VGQKNSFTVDCSKAGTNMMMVGVHGPKTPCEEVYVKHMGNRVYNVTYTVKEKGDYILIVK 2710

Query: 2694 WGDEHIPGSPYRVLVP 2741
            WGDE +PGSP++V VP
Sbjct: 2711 WGDESVPGSPFKVNVP 2726



 Score =  701 bits (1809), Expect = 0.0
 Identities = 408/888 (45%), Positives = 526/888 (59%), Gaps = 12/888 (1%)
 Frame = +3

Query: 111  WAPERPLVGVNGLDVTSLRPFDLVIPFTIKKGEITGEVRMPSGKVAQPAITDNKDGTVTV 290
            WA E P+V V  L+ + LRPF+LVIPFT++KGE+TGEVRMPSGK A+P ITDNKDGT+TV
Sbjct: 1767 WATEEPVVPVEPLE-SMLRPFNLVIPFTVQKGELTGEVRMPSGKTARPNITDNKDGTITV 1825

Query: 291  RYAPSEAGLHEMDIRYDNMHIPGSPLQFYVDYVNCGHVTAYGPGLSHGVVNKPAVFTVNT 470
            RYAP+E GLH+M I+YD  HIPGSPLQFYVD +N  HV+AYGPGLSHG+VNKPA FT+ T
Sbjct: 1826 RYAPTEKGLHQMGIKYDGNHIPGSPLQFYVDAINSRHVSAYGPGLSHGMVNKPATFTIVT 1885

Query: 471  KDAGEGGLSLAIEGPSKAEISCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTA 650
            KDAGEGGLSLA+EGPSKAEI+C DN+DGTC+VSYLP  PGDYSI+V+++++HIPGSPFTA
Sbjct: 1886 KDAGEGGLSLAVEGPSKAEITCKDNKDGTCTVSYLPTAPGDYSIIVRFDDKHIPGSPFTA 1945

Query: 651  RVTGDDSMRMSHLKVGSAADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGIS 830
            ++TGDDSMR S L VG++ D+ + I+E DLS LTA++  PSG EEPCLLKRL N H+GIS
Sbjct: 1946 KITGDDSMRTSQLNVGTSTDVSLKITEGDLSQLTASIRAPSGNEEPCLLKRLPNRHIGIS 2005

Query: 831  FVPKETGEHLVHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEGHTFEPAEFII 1010
            F PKE GEH+V V+K+G+HV +SP  +++  SEIGDAS+VRV G+GL EG TF+ AEFI+
Sbjct: 2006 FTPKEVGEHVVSVRKSGKHVTNSPFKILVGPSEIGDASKVRVWGKGLSEGQTFQVAEFIV 2065

Query: 1011 DTRDAGYGGLSLSIEGPSKVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPF 1190
            DTR+AGYGGL LSIEGPSKVDIN ED+EDGTC+VTYCPTEPG YIINIKFAD+HVPGSPF
Sbjct: 2066 DTRNAGYGGLGLSIEGPSKVDINCEDMEDGTCKVTYCPTEPGTYIINIKFADKHVPGSPF 2125

Query: 1191 SVKVTGEGRVKESITRRQRAPSVANVGSHCDLSLKIPEISIQDMTAQVTSPSGKSHEAEI 1370
            +VKVTGEGR+KESITRR++APS+A +GS CDL+LKIP    Q ++AQ       +  +  
Sbjct: 2126 TVKVTGEGRMKESITRRRQAPSIATIGSTCDLNLKIPGNWFQMVSAQERLTRTFTRSSHT 2185

Query: 1371 VEGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPG-LE 1547
                  T   +    E     V V+   Q V G PF    G        + R G  G + 
Sbjct: 2186 YTRTERTEISKTRGGET-KREVRVEESTQ-VGGDPFPAVFGDF----LGRERLGSFGSIT 2239

Query: 1548 RAEAGVPAEFSIWTREAGAGGLAIAVEGPS-KAEIS-FEDRKDGSCGVAYVVQEPGDYEV 1721
            R + G          EA +  +   V  PS K E +   + +D +  V +V QE G + V
Sbjct: 2240 RQQEG----------EASSQDMTAQVTSPSGKTEAAEIVEGEDSAYSVRFVPQEMGPHTV 2289

Query: 1722 SVKFNEEHIPDSPFVVPVAS-PSGDARRLTVSSLQESGLKVNQPASFAV-SLNGAKGAID 1895
            +VK+  +H+P SPF   V     G A ++              PA F++ +     G + 
Sbjct: 2290 TVKYRGQHVPGSPFQFTVGPLGEGGAHKVRAGGTGLERGVAGVPAEFSIWTREAGAGGLS 2349

Query: 1896 AKVHSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGH 2075
              V  PS A  E    +       V ++ +E G Y + +KFN  HIP SPF + V     
Sbjct: 2350 IAVEGPSKA--EIAFEDRKDGSCGVSYVVQEPGDYEVSIKFNDEHIPDSPFVVPVA--SL 2405

Query: 2076 GGDPGLVSAYGAGLEGGVTGSPAEFIVNTSNAGAGALSVTIDGPSKVKMDC---QECPEG 2246
              D   ++       G     PA F V   N   G +   +  PS    +C   +   + 
Sbjct: 2406 SDDARRLTVTSLQETGLKVNQPASFAVQL-NGARGVIDARVHTPSGAVEECYVSELDSDK 2464

Query: 2247 YRVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSVFVDSLTKTX 2426
            + + + P   G + I +K+ G  HI GSPFK RV       +  L               
Sbjct: 2465 HTIRFIPHENGVHSIDVKFNGA-HIPGSPFKIRVGEQSQAGDPGL--------------- 2508

Query: 2427 XXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKAGNNMLLVGVHGP---RT 2597
                             V A G GL     G    F V+   AG+  L V + GP   + 
Sbjct: 2509 -----------------VSAYGPGLEGGTTGVSSEFIVNTQNAGSGALSVTIDGPSKVQL 2551

Query: 2598 PCEEILVKHVGSRLYSVSYLLKDKGEYTLVVKW-GDEHIPGSPYRVLV 2738
             C E    HV      V+Y     G Y + +K+ G +HI GSP++  V
Sbjct: 2552 DCRECPEGHV------VTYTPMAPGNYLIAIKYGGPQHIVGSPFKAKV 2593



 Score =  344 bits (883), Expect = 2e-94
 Identities = 289/917 (31%), Positives = 421/917 (45%), Gaps = 70/917 (7%)
 Frame = +3

Query: 186  PFTIK-KGEITGEVRMPSGKVAQPAIT--DNKDGTVTVRYAPSEAGLHEMDIRYDNMHIP 356
            PF+I  KG  TG + +      +  I   DN DG+  V Y P+E G + ++I +   HIP
Sbjct: 1083 PFSIDTKGAGTGGLGLTVEGPCEAKIECQDNGDGSCAVSYLPTEPGEYTINILFAEAHIP 1142

Query: 357  GSPLQFYVDYV-NCGHVTAYGPGLSHGVVNKPAVFTVNTKDAGEGGLSLAI--EGPSKAE 527
            GSP +  +  V +   V A GPGL  G   + A FTV+  +AGE  L++ I  +   KAE
Sbjct: 1143 GSPFKATIQPVFDPSKVRASGPGLERGKAGEAATFTVDCSEAGEAELTIEILSDAGVKAE 1202

Query: 528  ISCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARVTGDDSMRMSHLKVGSAA 707
            +   +N DGT  ++Y P  PG Y+I +KY    IP   F  RV    ++  S +KV    
Sbjct: 1203 VLIQNNADGTYHITYSPAFPGTYTITIKYGGHPIP--KFPTRVHVQPAVDTSGIKVSGPG 1260

Query: 708  DIPINISE-------TDLSLLTAT--------VVPPSGREEPCLLKRLRNGHVGISFVPK 842
              P  +          D   LTAT        V+ PSG +    +    +G   + +   
Sbjct: 1261 VEPHGVLREVTTEFTVDARSLTATGGNHVTARVLNPSGAKTDTYVTDNGDGTYRVQYTAY 1320

Query: 843  ETGEHLVHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEGHTFEPAEFIIDTRD 1022
            E G HLV V  +   V  SP  V +++    D +RVR  G GL  G   +   F ++TR 
Sbjct: 1321 EEGVHLVEVLYDEVAVPKSPFRVGVTEG--CDPTRVRAFGPGLEGGLVNKANRFTVETRG 1378

Query: 1023 AGYGGLSLSIEGPSKVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKV 1202
            AG GGL L+IEGPS+  ++ +D +DG+C V Y P  PG+Y +NI F  Q +PGSPF V V
Sbjct: 1379 AGTGGLGLAIEGPSEAKMSCKDNKDGSCTVEYIPFTPGDYDVNITFGGQPIPGSPFRVPV 1438

Query: 1203 ---TGEGRVKES-----ITRRQRAPSVANVGSHCDLSLKIPEISIQDMTAQVTSPSGKSH 1358
                  G+VK S        R R P    V   C  + + P      +   V  P+G + 
Sbjct: 1439 KDVVDPGKVKCSGPGLGTGVRARVPQTFTVD--CSQAGRAP------LQVAVLGPTGVAE 1490

Query: 1359 EAEIVEGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGP 1538
              E+ +  + T+ + + PA  G +TV+VKY  Q VP SPF+  V P  +  A KVRA GP
Sbjct: 1491 PVEVRDNGDGTHTVHYTPATDGPYTVAVKYADQEVPRSPFKIKVLPSHD--ASKVRASGP 1548

Query: 1539 GLERA--EAGVPAEFSIWTREAGAGGLAIAV---EG-PSKAEISFEDRKDGSCGVAYVVQ 1700
            GL  +   A +P EF+I  R+AG G L + +   EG P KA I   D  DG+  V+Y+  
Sbjct: 1549 GLNASGIPASLPVEFTIDARDAGQGLLTVQILDPEGKPKKANI--RDNGDGTYTVSYLPD 1606

Query: 1701 EPGDYEVSVKFNEEHIPDSPFVVPVASPSGDARRLTVS-SLQESGL--------KVNQPA 1853
              G Y +++K+  + IP SPF +  A P+GDA +  V+ S+   GL        ++ +  
Sbjct: 1607 MSGRYTITIKYGGDEIPYSPFRIH-ALPTGDASKCLVTVSIGGHGLGACLGPRIQIGEET 1665

Query: 1854 SFAVSLNGA-KGAIDAKVHSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTH 2030
               V    A KG +   V +P GA  +  V E     + + +   E G Y+I ++F G H
Sbjct: 1666 VITVDAKAAGKGKVTCTVSTPDGAELDVDVVENHDGTFDIYYTAPEPGKYVITIRFGGEH 1725

Query: 2031 IPGSPFKI----------------RVGEPGHGGDPGLVSAYGAGLEGGVTGSPAEFIVNT 2162
            IP SPF +                ++ +P     PG    + A  E  V   P E ++  
Sbjct: 1726 IPNSPFHVLACDPLPHVEEPAEMLQMRQPYAPLRPGTCPTHWATEEPVVPVEPLESMLRP 1785

Query: 2163 SN------AGAGALSVTIDGPS--KVKMDCQECPEG-YRVTYTPMAPGSYLISIKYGGPY 2315
             N         G L+  +  PS    + +  +  +G   V Y P   G + + IKY G  
Sbjct: 1786 FNLVIPFTVQKGELTGEVRMPSGKTARPNITDNKDGTITVRYAPTEKGLHQMGIKYDG-N 1844

Query: 2316 HIGGSPFKARVTGHRLVSNHSLHETSSVFVDSLTKTXXXXXXXXXXXXXXXXSKVLAKGL 2495
            HI GSP +                    +VD++                     V A G 
Sbjct: 1845 HIPGSPLQ-------------------FYVDAINS-----------------RHVSAYGP 1868

Query: 2496 GLSKAYVGQKGSFTVDCSKAGNNMLLVGVHGPRTPCEEILVKHVGSRLYSVSYLLKDKGE 2675
            GLS   V +  +FT+    AG   L + V GP     EI  K       +VSYL    G+
Sbjct: 1869 GLSHGMVNKPATFTIVTKDAGEGGLSLAVEGPSK--AEITCKDNKDGTCTVSYLPTAPGD 1926

Query: 2676 YTLVVKWGDEHIPGSPY 2726
            Y+++V++ D+HIPGSP+
Sbjct: 1927 YSIIVRFDDKHIPGSPF 1943



 Score =  323 bits (828), Expect = 5e-88
 Identities = 251/905 (27%), Positives = 403/905 (44%), Gaps = 59/905 (6%)
 Frame = +3

Query: 201  KGEITGEVRMPSGKVAQPAITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFYV 380
            + E+T E+   +G  A+  I +N DGT  + Y+P+  G + + I+Y    IP  P + +V
Sbjct: 1186 EAELTIEILSDAGVKAEVLIQNNADGTYHITYSPAFPGTYTITIKYGGHPIPKFPTRVHV 1245

Query: 381  D-YVNCGHVTAYGPGLS-HGVVNKPAV-FTVNTKD---AGEGGLSLAIEGPS--KAEISC 536
               V+   +   GPG+  HGV+ +    FTV+ +     G   ++  +  PS  K +   
Sbjct: 1246 QPAVDTSGIKVSGPGVEPHGVLREVTTEFTVDARSLTATGGNHVTARVLNPSGAKTDTYV 1305

Query: 537  TDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARVT-GDDSMRMSHLKVG----- 698
            TDN DGT  V Y     G + + V Y+E  +P SPF   VT G D  R+     G     
Sbjct: 1306 TDNGDGTYRVQYTAYEEGVHLVEVLYDEVAVPKSPFRVGVTEGCDPTRVRAFGPGLEGGL 1365

Query: 699  --SAADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVK 872
               A    +         L   +  PS  +  C  K  ++G   + ++P   G++ V++ 
Sbjct: 1366 VNKANRFTVETRGAGTGGLGLAIEGPSEAKMSC--KDNKDGSCTVEYIPFTPGDYDVNIT 1423

Query: 873  KNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEG-HTFEPAEFIIDTRDAGYGGLSLS 1049
              GQ +  SP  V +   ++ D  +V+ SG GL  G     P  F +D   AG   L ++
Sbjct: 1424 FGGQPIPGSPFRVPVK--DVVDPGKVKCSGPGLGTGVRARVPQTFTVDCSQAGRAPLQVA 1481

Query: 1050 IEGPSKV--DINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTGEGRVK 1223
            + GP+ V   +   D  DGT  V Y P   G Y + +K+ADQ VP SPF +KV       
Sbjct: 1482 VLGPTGVAEPVEVRDNGDGTHTVHYTPATDGPYTVAVKYADQEVPRSPFKIKVLPS---H 1538

Query: 1224 ESITRRQRAPSVANVGSHCDLSLKIPEISIQD-----MTAQVTSPSGKSHEAEIVEGENH 1388
            ++   R   P +   G    L ++   I  +D     +T Q+  P GK  +A I +  + 
Sbjct: 1539 DASKVRASGPGLNASGIPASLPVEFT-IDARDAGQGLLTVQILDPEGKPKKANIRDNGDG 1597

Query: 1389 TYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRA--GGPGL-----E 1547
            TY + ++P   G +T+++KY G  +P SPF+    P G+     V    GG GL      
Sbjct: 1598 TYTVSYLPDMSGRYTITIKYGGDEIPYSPFRIHALPTGDASKCLVTVSIGGHGLGACLGP 1657

Query: 1548 RAEAGVPAEFSIWTREAGAGGLAIAVEGPSKAEISFE--DRKDGSCGVAYVVQEPGDYEV 1721
            R + G     ++  + AG G +   V  P  AE+  +  +  DG+  + Y   EPG Y +
Sbjct: 1658 RIQIGEETVITVDAKAAGKGKVTCTVSTPDGAELDVDVVENHDGTFDIYYTAPEPGKYVI 1717

Query: 1722 SVKFNEEHIPDSPFVVPVASP----SGDARRLTVS---------------SLQESGLKVN 1844
            +++F  EHIP+SPF V    P       A  L +                + +E  + V 
Sbjct: 1718 TIRFGGEHIPNSPFHVLACDPLPHVEEPAEMLQMRQPYAPLRPGTCPTHWATEEPVVPVE 1777

Query: 1845 ------QPASFAVSLNGAKGAIDAKVHSPSGALEECYVTEIDQDKYAVRFIPRENGVYLI 2006
                  +P +  +     KG +  +V  PSG      +T+       VR+ P E G++ +
Sbjct: 1778 PLESMLRPFNLVIPFTVQKGELTGEVRMPSGKTARPNITDNKDGTITVRYAPTEKGLHQM 1837

Query: 2007 DVKFNGTHIPGSPFKIRVGEPGHGGDPGLVSAYGAGLEGGVTGSPAEFIVNTSNAGAGAL 2186
             +K++G HIPGSP +  V           VSAYG GL  G+   PA F + T +AG G L
Sbjct: 1838 GIKYDGNHIPGSPLQFYVDAINSRH----VSAYGPGLSHGMVNKPATFTIVTKDAGEGGL 1893

Query: 2187 SVTIDGPSKVKMDCQECPEGY-RVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRL 2363
            S+ ++GPSK ++ C++  +G   V+Y P APG Y I +++    HI GSPF A++TG   
Sbjct: 1894 SLAVEGPSKAEITCKDNKDGTCTVSYLPTAPGDYSIIVRFDDK-HIPGSPFTAKITG--- 1949

Query: 2364 VSNHSLHETSSVFVDSLTKTXXXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVD 2543
                          D   +T                          S+  VG     ++ 
Sbjct: 1950 --------------DDSMRT--------------------------SQLNVGTSTDVSLK 1969

Query: 2544 CSKAGNNMLLVGVHGPRTPCEEILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSP 2723
             ++   + L   +  P    E  L+K + +R   +S+  K+ GE+ + V+   +H+  SP
Sbjct: 1970 ITEGDLSQLTASIRAPSGNEEPCLLKRLPNRHIGISFTPKEVGEHVVSVRKSGKHVTNSP 2029

Query: 2724 YRVLV 2738
            +++LV
Sbjct: 2030 FKILV 2034



 Score =  319 bits (817), Expect = 9e-87
 Identities = 257/861 (29%), Positives = 387/861 (44%), Gaps = 35/861 (4%)
 Frame = +3

Query: 258  ITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFYV-DYVNCGHVTAYGPGLSHG 434
            I DN D + TV+Y   + G   + + Y    +P SP    V   ++   V   G   S  
Sbjct: 921  IIDNHDYSYTVKYTAVQQGNMAVTVTYGGDPVPKSPFVVNVAPPLDLSKVKVQGLN-SKV 979

Query: 435  VVNKPAVFTVNTKDAG-EGGLSLAIEGPSKAEISCTDNQDGTC---SVSYLPVLPGDYSI 602
             V +   F+VNT+ AG +G L + +  PS+  I C     G     +V Y+P   G Y +
Sbjct: 980  AVGQEQAFSVNTRGAGGQGQLDVRMTSPSRRPIPCKLEPGGGAEAQAVRYMPPEEGPYKV 1039

Query: 603  LVKYNEQHIPGSPFTAR--VTGDDSMRMSH---LK---VGSAADIPINISETDLSLLTAT 758
             + Y+   +PGSPF     +  D S   ++   LK   VG+ A   I+        L  T
Sbjct: 1040 DITYDGHPVPGSPFAVEGVLPPDPSKVCAYGPGLKGGLVGTPAPFSIDTKGAGTGGLGLT 1099

Query: 759  VVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNGQHVASSPIPVVISQSEIGD 938
            V  P   +  C  +   +G   +S++P E GE+ +++     H+  SP    I    + D
Sbjct: 1100 VEGPCEAKIEC--QDNGDGSCAVSYLPTEPGEYTINILFAEAHIPGSPFKATIQP--VFD 1155

Query: 939  ASRVRVSGRGLHEGHTFEPAEFIIDTRDAGYGGLSLSI--EGPSKVDINTEDLEDGTCRV 1112
             S+VR SG GL  G   E A F +D  +AG   L++ I  +   K ++  ++  DGT  +
Sbjct: 1156 PSKVRASGPGLERGKAGEAATFTVDCSEAGEAELTIEILSDAGVKAEVLIQNNADGTYHI 1215

Query: 1113 TYCPTEPGNYIINIKFADQHVPGSPFSV-----------KVTGEGRVKESITRRQRAPSV 1259
            TY P  PG Y I IK+    +P  P  V           KV+G G     + R       
Sbjct: 1216 TYSPAFPGTYTITIKYGGHPIPKFPTRVHVQPAVDTSGIKVSGPGVEPHGVLREVTTEFT 1275

Query: 1260 ANVGSHCDLSLKIPEISIQDMTAQVTSPSGKSHEAEIVEGENHTYCIRFVPAEMGMHTVS 1439
             +  S       +       +TA+V +PSG   +  + +  + TY +++   E G+H V 
Sbjct: 1276 VDARS-------LTATGGNHVTARVLNPSGAKTDTYVTDNGDGTYRVQYTAYEEGVHLVE 1328

Query: 1440 VKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLERAEAGVPAEFSIWTREAGAGGLAI 1619
            V Y    VP SPF+  VG        +VRA GPGLE         F++ TR AG GGL +
Sbjct: 1329 VLYDEVAVPKSPFR--VGVTEGCDPTRVRAFGPGLEGGLVNKANRFTVETRGAGTGGLGL 1386

Query: 1620 AVEGPSKAEISFEDRKDGSCGVAYVVQEPGDYEVSVKFNEEHIPDSPFVVPVASPSGDAR 1799
            A+EGPS+A++S +D KDGSC V Y+   PGDY+V++ F  + IP SPF VPV       +
Sbjct: 1387 AIEGPSEAKMSCKDNKDGSCTVEYIPFTPGDYDVNITFGGQPIPGSPFRVPVKDVVDPGK 1446

Query: 1800 RLTVSSLQESGLKVNQPASFAVSLNGA-KGAIDAKVHSPSGALEECYVTEIDQDKYAVRF 1976
                     +G++   P +F V  + A +  +   V  P+G  E   V +     + V +
Sbjct: 1447 VKCSGPGLGTGVRARVPQTFTVDCSQAGRAPLQVAVLGPTGVAEPVEVRDNGDGTHTVHY 1506

Query: 1977 IPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPGLVSAYGAGLE-GGVTGS-PAEF 2150
             P  +G Y + VK+    +P SPFKI+V  P H  D   V A G GL   G+  S P EF
Sbjct: 1507 TPATDGPYTVAVKYADQEVPRSPFKIKV-LPSH--DASKVRASGPGLNASGIPASLPVEF 1563

Query: 2151 IVNTSNAGAGALSVTIDGP--SKVKMDCQECPEG-YRVTYTPMAPGSYLISIKYGGPYHI 2321
             ++  +AG G L+V I  P     K + ++  +G Y V+Y P   G Y I+IKYGG   I
Sbjct: 1564 TIDARDAGQGLLTVQILDPEGKPKKANIRDNGDGTYTVSYLPDMSGRYTITIKYGGD-EI 1622

Query: 2322 GGSPFKARVTGHRLVSNHSLHETSSVFVDSLTKTXXXXXXXXXXXXXXXXSKVLAKGLGL 2501
              SPF+     H L +  +     +V +                            GLG 
Sbjct: 1623 PYSPFRI----HALPTGDASKCLVTVSIG-------------------------GHGLGA 1653

Query: 2502 ---SKAYVGQKGSFTVDCSKAGNNMLLVGVHGPRTPCEEILVKHVGSRLYSVSYLLKDKG 2672
                +  +G++   TVD   AG   +   V  P     ++ V       + + Y   + G
Sbjct: 1654 CLGPRIQIGEETVITVDAKAAGKGKVTCTVSTPDGAELDVDVVENHDGTFDIYYTAPEPG 1713

Query: 2673 EYTLVVKWGDEHIPGSPYRVL 2735
            +Y + +++G EHIP SP+ VL
Sbjct: 1714 KYVITIRFGGEHIPNSPFHVL 1734



 Score =  311 bits (798), Expect = 2e-84
 Identities = 246/855 (28%), Positives = 388/855 (45%), Gaps = 38/855 (4%)
 Frame = +3

Query: 288  VRYAPSEAGLHEMDIRYDNMHIPGSPLQFYVDYV---NCGHVTAYGPGLSHGVVNKPAVF 458
            VRY P E G +++DI YD   +PGSP  F V+ V   +   V AYGPGL  G+V  PA F
Sbjct: 1027 VRYMPPEEGPYKVDITYDGHPVPGSP--FAVEGVLPPDPSKVCAYGPGLKGGLVGTPAPF 1084

Query: 459  TVNTKDAGEGGLSLAIEGPSKAEISCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGS 638
            +++TK AG GGL L +EGP +A+I C DN DG+C+VSYLP  PG+Y+I + + E HIPGS
Sbjct: 1085 SIDTKGAGTGGLGLTVEGPCEAKIECQDNGDGSCAVSYLPTEPGEYTINILFAEAHIPGS 1144

Query: 639  PFTARVT---GDDSMRMS-----HLKVGSAADIPINISETDLSLLTATVVPPSGREEPCL 794
            PF A +        +R S       K G AA   ++ SE   + LT  ++  +G +   L
Sbjct: 1145 PFKATIQPVFDPSKVRASGPGLERGKAGEAATFTVDCSEAGEAELTIEILSDAGVKAEVL 1204

Query: 795  LKRLRNGHVGISFVPKETGEHLVHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLH 974
            ++   +G   I++ P   G + + +K  G  +   P  V +  +   D S ++VSG G+ 
Sbjct: 1205 IQNNADGTYHITYSPAFPGTYTITIKYGGHPIPKFPTRVHVQPAV--DTSGIKVSGPGVE 1262

Query: 975  EGHTFEPA--EFIIDTRD---AGYGGLSLSIEGPS--KVDINTEDLEDGTCRVTYCPTEP 1133
                      EF +D R     G   ++  +  PS  K D    D  DGT RV Y   E 
Sbjct: 1263 PHGVLREVTTEFTVDARSLTATGGNHVTARVLNPSGAKTDTYVTDNGDGTYRVQYTAYEE 1322

Query: 1134 GNYIINIKFADQHVPGSPFSVKVTGEGRVKESITRRQRAPSVANVGSHCDLSLKIPEISI 1313
            G +++ + + +  VP SPF V VT EG     +           V      +++      
Sbjct: 1323 GVHLVEVLYDEVAVPKSPFRVGVT-EGCDPTRVRAFGPGLEGGLVNKANRFTVETRGAGT 1381

Query: 1314 QDMTAQVTSPSGKSHEAEIVEGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVG 1493
              +   +  PS      +  + ++ +  + ++P   G + V++ + GQ +PGSPF+  V 
Sbjct: 1382 GGLGLAIEGPSEAKMSCK--DNKDGSCTVEYIPFTPGDYDVNITFGGQPIPGSPFRVPVK 1439

Query: 1494 PLGEGGAHKVRAGGPGLERA-EAGVPAEFSIWTREAGAGGLAIAVEGPSKAE--ISFEDR 1664
             + + G  KV+  GPGL     A VP  F++   +AG   L +AV GP+     +   D 
Sbjct: 1440 DVVDPG--KVKCSGPGLGTGVRARVPQTFTVDCSQAGRAPLQVAVLGPTGVAEPVEVRDN 1497

Query: 1665 KDGSCGVAYVVQEPGDYEVSVKFNEEHIPDSPFVVPVASPSGDARRLTVSS--LQESGLK 1838
             DG+  V Y     G Y V+VK+ ++ +P SPF + V  PS DA ++  S   L  SG+ 
Sbjct: 1498 GDGTHTVHYTPATDGPYTVAVKYADQEVPRSPFKIKVL-PSHDASKVRASGPGLNASGIP 1556

Query: 1839 VNQPASFAVSLNGA-KGAIDAKVHSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVK 2015
             + P  F +    A +G +  ++  P G  ++  + +     Y V ++P  +G Y I +K
Sbjct: 1557 ASLPVEFTIDARDAGQGLLTVQILDPEGKPKKANIRDNGDGTYTVSYLPDMSGRYTITIK 1616

Query: 2016 FNGTHIPGSPFKIRVGEPGHG---------GDPGLVSAYGAGLEGGVTGSPAEFIVNTSN 2168
            + G  IP SPF+I     G           G  GL +  G  ++    G      V+   
Sbjct: 1617 YGGDEIPYSPFRIHALPTGDASKCLVTVSIGGHGLGACLGPRIQ---IGEETVITVDAKA 1673

Query: 2169 AGAGALSVTIDGPSKVKMDCQ--ECPEG-YRVTYTPMAPGSYLISIKYGGPYHIGGSPFK 2339
            AG G ++ T+  P   ++D    E  +G + + YT   PG Y+I+I++GG  HI  SPF 
Sbjct: 1674 AGKGKVTCTVSTPDGAELDVDVVENHDGTFDIYYTAPEPGKYVITIRFGGE-HIPNSPFH 1732

Query: 2340 ARVTG--HRLVSNHSLHETSSVFVDSLTKTXXXXXXXXXXXXXXXXSKVLAKGLGLSKAY 2513
                     +     + +    +      T                 + + +   L   +
Sbjct: 1733 VLACDPLPHVEEPAEMLQMRQPYAPLRPGTCPTHWATEEPVVPVEPLESMLRPFNLVIPF 1792

Query: 2514 VGQKGSFTVDCSKAGNNMLLVGVHGPRTPCEEILVKHVGSRLYSVSYLLKDKGEYTLVVK 2693
              QKG  T +          V +   +T    I     G+   +V Y   +KG + + +K
Sbjct: 1793 TVQKGELTGE----------VRMPSGKTARPNITDNKDGT--ITVRYAPTEKGLHQMGIK 1840

Query: 2694 WGDEHIPGSPYRVLV 2738
            +   HIPGSP +  V
Sbjct: 1841 YDGNHIPGSPLQFYV 1855



 Score =  307 bits (786), Expect = 4e-83
 Identities = 266/891 (29%), Positives = 405/891 (45%), Gaps = 45/891 (5%)
 Frame = +3

Query: 201  KGEITGEVRMPSGKVAQPAITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFYV 380
            KG++    +   G      +  N DGT    Y P++   H + + +  +++P SP +  V
Sbjct: 700  KGDLKLYAQDADGCPIDIKVIPNGDGTFRCSYVPTKPIKHTIIVSWGGVNVPKSPFRVNV 759

Query: 381  -DYVNCGHVTAYGPGLSHG--VVNKPAVFTVNTKDAGEGGLSLAIE------GPSKAEI- 530
             +  +   V  YGPG+       N+P  FTV+  +AG+G +S+ I+      GP +A+I 
Sbjct: 760  GEGSHPERVKVYGPGVEKTGLKANEPTYFTVDCSEAGQGDVSIGIKCAPGVVGPVEADID 819

Query: 531  -SCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARVTGDDSMRMSHLK----- 692
                 N + T +V Y P   G Y+I+V +  Q IP SPF  +V  D S   S +K     
Sbjct: 820  FDIIKNDNDTFTVKYTPPGAGHYTIMVLFANQEIPASPFHIKV--DPSHDASKVKAEGPG 877

Query: 693  -------VGSAADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVG--ISFVPKE 845
                   VG      +       + L       +  E     + + N      + +   +
Sbjct: 878  LSRTGVEVGKPTHFTVLTKGAGKAKLDVHFAGAAKGEAVRDFEIIDNHDYSYTVKYTAVQ 937

Query: 846  TGEHLVHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEGHTFEPAEFIIDTRDA 1025
             G   V V   G  V  SP   V++ +   D S+V+V G         E A F ++TR A
Sbjct: 938  QGNMAVTVTYGGDPVPKSPF--VVNVAPPLDLSKVKVQGLNSKVAVGQEQA-FSVNTRGA 994

Query: 1026 -GYGGLSLSIEGPSKVDINTEDLEDG----TCRVTYCPTEPGNYIINIKFADQHVPGSPF 1190
             G G L + +  PS+  I  + LE G       V Y P E G Y ++I +    VPGSPF
Sbjct: 995  GGQGQLDVRMTSPSRRPIPCK-LEPGGGAEAQAVRYMPPEEGPYKVDITYDGHPVPGSPF 1053

Query: 1191 SVKVTGEGRVKESITR-RQRAPSVAN--VGSHCDLSLKIPEISIQDMTAQVTSPSGKSHE 1361
            +V    EG +    ++     P +    VG+    S+         +   V  P     E
Sbjct: 1054 AV----EGVLPPDPSKVCAYGPGLKGGLVGTPAPFSIDTKGAGTGGLGLTVEGPCEAKIE 1109

Query: 1362 AEIVEGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPG 1541
             +  +  + +  + ++P E G +T+++ +   H+PGSPF+ T+ P+ +    KVRA GPG
Sbjct: 1110 CQ--DNGDGSCAVSYLPTEPGEYTINILFAEAHIPGSPFKATIQPVFD--PSKVRASGPG 1165

Query: 1542 LERAEAGVPAEFSIWTREAGAGGLAIAV--EGPSKAEISFEDRKDGSCGVAYVVQEPGDY 1715
            LER +AG  A F++   EAG   L I +  +   KAE+  ++  DG+  + Y    PG Y
Sbjct: 1166 LERGKAGEAATFTVDCSEAGEAELTIEILSDAGVKAEVLIQNNADGTYHITYSPAFPGTY 1225

Query: 1716 EVSVKFNEEHIPDSPFVVPVASPSGDARRLTVS--SLQESGLKVNQPASFAV---SLNGA 1880
             +++K+    IP  P  V V  P+ D   + VS   ++  G+       F V   SL   
Sbjct: 1226 TITIKYGGHPIPKFPTRVHV-QPAVDTSGIKVSGPGVEPHGVLREVTTEFTVDARSLTAT 1284

Query: 1881 KG-AIDAKVHSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIR 2057
             G  + A+V +PSGA  + YVT+     Y V++   E GV+L++V ++   +P SPF++ 
Sbjct: 1285 GGNHVTARVLNPSGAKTDTYVTDNGDGTYRVQYTAYEEGVHLVEVLYDEVAVPKSPFRVG 1344

Query: 2058 VGEPGHGGDPGLVSAYGAGLEGGVTGSPAEFIVNTSNAGAGALSVTIDGPSKVKMDCQEC 2237
            V E   G DP  V A+G GLEGG+      F V T  AG G L + I+GPS+ KM C++ 
Sbjct: 1345 VTE---GCDPTRVRAFGPGLEGGLVNKANRFTVETRGAGTGGLGLAIEGPSEAKMSCKDN 1401

Query: 2238 PEG-YRVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSVFVDSL 2414
             +G   V Y P  PG Y ++I +GG   I GSPF+  V                  VD  
Sbjct: 1402 KDGSCTVEYIPFTPGDYDVNITFGG-QPIPGSPFRVPVKD---------------VVD-- 1443

Query: 2415 TKTXXXXXXXXXXXXXXXXSKVLAKGLGLS---KAYVGQKGSFTVDCSKAGNNMLLVGVH 2585
                                KV   G GL    +A V Q  +FTVDCS+AG   L V V 
Sbjct: 1444 ------------------PGKVKCSGPGLGTGVRARVPQ--TFTVDCSQAGRAPLQVAVL 1483

Query: 2586 GPRTPCEEILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLV 2738
            GP    E + V+  G   ++V Y     G YT+ VK+ D+ +P SP+++ V
Sbjct: 1484 GPTGVAEPVEVRDNGDGTHTVHYTPATDGPYTVAVKYADQEVPRSPFKIKV 1534



 Score =  300 bits (769), Expect = 3e-81
 Identities = 249/895 (27%), Positives = 384/895 (42%), Gaps = 50/895 (5%)
 Frame = +3

Query: 204  GEITGEVRMPSGKVAQPAITDN--KDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFY 377
            GE+   +  P G   +  +  N  KD T  V Y P  AGLH++ + +   +I  SP +  
Sbjct: 309  GEVLVYIEDPEGHTEEAKVVPNNDKDRTYAVSYVPKVAGLHKVTVLFAGQNIERSPFEVN 368

Query: 378  VDYV--NCGHVTAYGPGLSH--GVVNKPAVFTVNTKDAGEGGLSLAIEGPS----KAEIS 533
            V     +   V+A GPGL     V NKP  F + T  AG G +++ I  P       E++
Sbjct: 369  VGMALGDANKVSARGPGLEPVGNVANKPTYFDIYTAGAGTGDVAVVIVDPQGRRDTVEVA 428

Query: 534  CTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARVT----------GDDSMRMS 683
              D  D T   +Y PV+ G +++ V +    I  SPF   V               ++  
Sbjct: 429  LEDKGDNTFRCTYRPVMEGPHTVHVAFAGAPITRSPFPVHVAEACNPNACRASGRGLQPK 488

Query: 684  HLKVGSAADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLV 863
             ++V   AD  +         L  TV  P G EEP  ++   +G     + P   G+++V
Sbjct: 489  GVRVKEVADFKVFTKGAGSGELKVTVKGPKGTEEPVKVREAGDGVFECEYYPVVPGKYVV 548

Query: 864  HVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEGHTFEPAEFIIDTRDAGYGGLS 1043
             +   G  +  SP  V +S      A +VR  G GL  G   + A+F+++      G L 
Sbjct: 549  TITWGGYAIPRSPFEVQVSPE--AGAQKVRAWGPGLETGQVGKSADFVVEAIGTEVGTLG 606

Query: 1044 LSIEGPSKVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTGEGRVK 1223
             SIEGPS+  I  +D  DG+C V Y PTEPG Y +++   D+ +  SPF   +  +    
Sbjct: 607  FSIEGPSQAKIECDDKGDGSCDVRYWPTEPGEYAVHVICDDEDIRDSPFIAHI--QPAPP 664

Query: 1224 ESITRRQRA------PSVANVGSHCDLSLKIPEISIQDMTAQVTSPSGKSHEAEIVEGEN 1385
            +    + +A      P+   V    + ++        D+        G   + +++   +
Sbjct: 665  DCFPDKVKAFGPGLEPTGCIVDRPAEFTIDARAAGKGDLKLYAQDADGCPIDIKVIPNGD 724

Query: 1386 HTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAH--KVRAGGPGLERA-- 1553
             T+   +VP +   HT+ V + G +VP SPF+  VG     G+H  +V+  GPG+E+   
Sbjct: 725  GTFRCSYVPTKPIKHTIIVSWGGVNVPKSPFRVNVGE----GSHPERVKVYGPGVEKTGL 780

Query: 1554 EAGVPAEFSIWTREAGAGGLAIAVE------GPSKAEISFEDRK--DGSCGVAYVVQEPG 1709
            +A  P  F++   EAG G ++I ++      GP +A+I F+  K  + +  V Y     G
Sbjct: 781  KANEPTYFTVDCSEAGQGDVSIGIKCAPGVVGPVEADIDFDIIKNDNDTFTVKYTPPGAG 840

Query: 1710 DYEVSVKFNEEHIPDSPFVVPVASPSGDARRLTVS--SLQESGLKVNQPASFAVSLNGAK 1883
             Y + V F  + IP SPF + V  PS DA ++      L  +G++V +P  F V   GA 
Sbjct: 841  HYTIMVLFANQEIPASPFHIKV-DPSHDASKVKAEGPGLSRTGVEVGKPTHFTVLTKGA- 898

Query: 1884 GAIDAKVH----SPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFK 2051
            G     VH    +   A+ +  + +     Y V++   + G   + V + G  +P SPF 
Sbjct: 899  GKAKLDVHFAGAAKGEAVRDFEIIDNHDYSYTVKYTAVQQGNMAVTVTYGGDPVPKSPFV 958

Query: 2052 IRVGEPGHGGDPGLVSAYGAGLEGGVTGSPAEFIVNTSNAGA-GALSVTIDGPSKVKMDC 2228
            + V  P    D   V   G   +  V G    F VNT  AG  G L V +  PS+  + C
Sbjct: 959  VNVAPP---LDLSKVKVQGLNSKVAV-GQEQAFSVNTRGAGGQGQLDVRMTSPSRRPIPC 1014

Query: 2229 QECP----EGYRVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSS 2396
            +  P    E   V Y P   G Y + I Y G + + GSPF                    
Sbjct: 1015 KLEPGGGAEAQAVRYMPPEEGPYKVDITYDG-HPVPGSPFAVE----------------- 1056

Query: 2397 VFVDSLTKTXXXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKAGNNMLLV 2576
                                     SKV A G GL    VG    F++D   AG   L +
Sbjct: 1057 ------------------GVLPPDPSKVCAYGPGLKGGLVGTPAPFSIDTKGAGTGGLGL 1098

Query: 2577 GVHGPRTPCE-EILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLV 2738
             V G   PCE +I  +  G    +VSYL  + GEYT+ + + + HIPGSP++  +
Sbjct: 1099 TVEG---PCEAKIECQDNGDGSCAVSYLPTEPGEYTINILFAEAHIPGSPFKATI 1150



 Score =  273 bits (699), Expect = 5e-73
 Identities = 171/478 (35%), Positives = 241/478 (50%), Gaps = 50/478 (10%)
 Frame = +3

Query: 207  EITGEVRMPSGKVAQPAITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFYVDY 386
            ++T +V  PSGK     I + +D   +VR+ P E G H + ++Y   H+PGSP QF V  
Sbjct: 2250 DMTAQVTSPSGKTEAAEIVEGEDSAYSVRFVPQEMGPHTVTVKYRGQHVPGSPFQFTVGP 2309

Query: 387  VNCG---HVTAYGPGLSHGVVNKPAVFTVNTKDAGEGGLSLAIEGPSKAEISCTDNQDGT 557
            +  G    V A G GL  GV   PA F++ T++AG GGLS+A+EGPSKAEI+  D +DG+
Sbjct: 2310 LGEGGAHKVRAGGTGLERGVAGVPAEFSIWTREAGAGGLSIAVEGPSKAEIAFEDRKDGS 2369

Query: 558  CSVSYLPVLPGDYSILVKYNEQHIPGSPFTARVTG--DDSMRMS-------HLKVGSAAD 710
            C VSY+   PGDY + +K+N++HIP SPF   V    DD+ R++        LKV   A 
Sbjct: 2370 CGVSYVVQEPGDYEVSIKFNDEHIPDSPFVVPVASLSDDARRLTVTSLQETGLKVNQPAS 2429

Query: 711  IPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNGQHV 890
              + ++     ++ A V  PSG  E C +  L +    I F+P E G H + VK NG H+
Sbjct: 2430 FAVQLNGAR-GVIDARVHTPSGAVEECYVSELDSDKHTIRFIPHENGVHSIDVKFNGAHI 2488

Query: 891  ASSPIPVVIS-QSEIGDASRVRVSGRGLHEGHTFEPAEFIIDTRDAGYGGLSLSIEGPSK 1067
              SP  + +  QS+ GD   V   G GL  G T   +EFI++T++AG G LS++I+GPSK
Sbjct: 2489 PGSPFKIRVGEQSQAGDPGLVSAYGPGLEGGTTGVSSEFIVNTQNAGSGALSVTIDGPSK 2548

Query: 1068 VDINTEDLEDGTCRVTYCPTEPGNYIINIKF-ADQHVPGSPFSVKVTG------------ 1208
            V ++  +  +G   VTY P  PGNY+I IK+   QH+ GSPF  KVTG            
Sbjct: 2549 VQLDCRECPEGHV-VTYTPMAPGNYLIAIKYGGPQHIVGSPFKAKVTGPRLSGGHSLHET 2607

Query: 1209 -----EGRVKESITR-------------------RQRAPSVANVGSHCDLSLKIPEISIQ 1316
                 E   K S +R                   R    S A VG     ++   +    
Sbjct: 2608 STVLVETVTKSSSSRGASYSSIPKFSSDASKVVTRGPGLSQAFVGQKNSFTVDCSKAGTN 2667

Query: 1317 DMTAQVTSPSGKSHEAEIVEGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTV 1490
             M   V  P     E  +    N  Y + +   E G + + VK+  + VPGSPF+  V
Sbjct: 2668 MMMVGVHGPKTPCEEVYVKHMGNRVYNVTYTVKEKGDYILIVKWGDESVPGSPFKVNV 2725



 Score =  273 bits (698), Expect = 6e-73
 Identities = 244/873 (27%), Positives = 373/873 (42%), Gaps = 40/873 (4%)
 Frame = +3

Query: 264  DNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFYVDYV--NC--GHVTAYGPGLSH 431
            D  DG+  VRY P+E G + + +  D+  I  SP   ++     +C    V A+GPGL  
Sbjct: 621  DKGDGSCDVRYWPTEPGEYAVHVICDDEDIRDSPFIAHIQPAPPDCFPDKVKAFGPGLEP 680

Query: 432  G--VVNKPAVFTVNTKDAGEGGLSLAIEGPSKA--EISCTDNQDGTCSVSYLPVLPGDYS 599
               +V++PA FT++ + AG+G L L  +       +I    N DGT   SY+P  P  ++
Sbjct: 681  TGCIVDRPAEFTIDARAAGKGDLKLYAQDADGCPIDIKVIPNGDGTFRCSYVPTKPIKHT 740

Query: 600  ILVKYNEQHIPGSPFTARVTGDDS-----------MRMSHLKVGSAADIPINISET---D 737
            I+V +   ++P SPF   V G+ S           +  + LK        ++ SE    D
Sbjct: 741  IIVSWGGVNVPKSPFRVNV-GEGSHPERVKVYGPGVEKTGLKANEPTYFTVDCSEAGQGD 799

Query: 738  LSL---LTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNGQHVASSPIP 908
            +S+       VV P   +    + +  N    + + P   G + + V    Q + +SP  
Sbjct: 800  VSIGIKCAPGVVGPVEADIDFDIIKNDNDTFTVKYTPPGAGHYTIMVLFANQEIPASPFH 859

Query: 909  VVISQSEIGDASRVRVSGRGLHEG--HTFEPAEFIIDTRDAGYGGLSLSIEGPSK----V 1070
            + +  S   DAS+V+  G GL        +P  F + T+ AG   L +   G +K     
Sbjct: 860  IKVDPSH--DASKVKAEGPGLSRTGVEVGKPTHFTVLTKGAGKAKLDVHFAGAAKGEAVR 917

Query: 1071 DINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTGEGRVKESITRRQRA 1250
            D    D  D +  V Y   + GN  + + +    VP SPF V V     +  S  + Q  
Sbjct: 918  DFEIIDNHDYSYTVKYTAVQQGNMAVTVTYGGDPVPKSPFVVNVAPP--LDLSKVKVQGL 975

Query: 1251 PSVANVGSHCDLSLKIPEISIQ-DMTAQVTSPSGKSHEAEIVEGEN-HTYCIRFVPAEMG 1424
             S   VG     S+       Q  +  ++TSPS +    ++  G       +R++P E G
Sbjct: 976  NSKVAVGQEQAFSVNTRGAGGQGQLDVRMTSPSRRPIPCKLEPGGGAEAQAVRYMPPEEG 1035

Query: 1425 MHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLERAEAGVPAEFSIWTREAGA 1604
             + V + Y G  VPGSP  F V  +      KV A GPGL+    G PA FSI T+ AG 
Sbjct: 1036 PYKVDITYDGHPVPGSP--FAVEGVLPPDPSKVCAYGPGLKGGLVGTPAPFSIDTKGAGT 1093

Query: 1605 GGLAIAVEGPSKAEISFEDRKDGSCGVAYVVQEPGDYEVSVKFNEEHIPDSPFVVPVASP 1784
            GGL + VEGP +A+I  +D  DGSC V+Y+  EPG+Y +++ F E HIP SPF   +  P
Sbjct: 1094 GGLGLTVEGPCEAKIECQDNGDGSCAVSYLPTEPGEYTINILFAEAHIPGSPFKATI-QP 1152

Query: 1785 SGDARRLTVSSLQESGLKVNQPASFAVSLNGA-KGAIDAKVHSPSGALEECYVTEIDQDK 1961
              D  ++  S       K  + A+F V  + A +  +  ++ S +G   E  +       
Sbjct: 1153 VFDPSKVRASGPGLERGKAGEAATFTVDCSEAGEAELTIEILSDAGVKAEVLIQNNADGT 1212

Query: 1962 YAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPGLVSAYGAGLEGGVTGSP 2141
            Y + + P   G Y I +K+ G  IP  P ++ V +P        VS  G    G +    
Sbjct: 1213 YHITYSPAFPGTYTITIKYGGHPIPKFPTRVHV-QPAVDTSGIKVSGPGVEPHGVLREVT 1271

Query: 2142 AEFIVNTSN---AGAGALSVTIDGPSKVKMDCQECPEG---YRVTYTPMAPGSYLISIKY 2303
             EF V+  +    G   ++  +  PS  K D      G   YRV YT    G +L+ + Y
Sbjct: 1272 TEFTVDARSLTATGGNHVTARVLNPSGAKTDTYVTDNGDGTYRVQYTAYEEGVHLVEVLY 1331

Query: 2304 GGPYHIGGSPFKARVTGHRLVSNHSLHETSSVFVDSLTKTXXXXXXXXXXXXXXXXSKVL 2483
                 +  SPF+  VT                                        ++V 
Sbjct: 1332 -DEVAVPKSPFRVGVT-----------------------------------EGCDPTRVR 1355

Query: 2484 AKGLGLSKAYVGQKGSFTVDCSKAGNNMLLVGVHGPRTPCEEILVKHVGSRLYSVSYLLK 2663
            A G GL    V +   FTV+   AG   L + + GP            GS   +V Y+  
Sbjct: 1356 AFGPGLEGGLVNKANRFTVETRGAGTGGLGLAIEGPSEAKMSCKDNKDGS--CTVEYIPF 1413

Query: 2664 DKGEYTLVVKWGDEHIPGSPYRVLVP*ALCPGQ 2762
              G+Y + + +G + IPGSP+RV V   + PG+
Sbjct: 1414 TPGDYDVNITFGGQPIPGSPFRVPVKDVVDPGK 1446



 Score =  235 bits (599), Expect = 2e-61
 Identities = 236/840 (28%), Positives = 365/840 (43%), Gaps = 47/840 (5%)
 Frame = +3

Query: 354  PGSPLQFYVDYVNCGHVTAYGPGLSH--GVVNKPAVFTVNTKDAGEGGLSLAIEGP---- 515
            PG+P++     +N     AYGPG+      V +PA FTV T DAG G + + IE P    
Sbjct: 265  PGAPVRS--KQLNPKKAIAYGPGIEPQGNTVLQPAHFTVQTVDAGVGEVLVYIEDPEGHT 322

Query: 516  SKAEISCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARV---TGDD---SMR 677
             +A++   +++D T +VSY+P + G + + V +  Q+I  SPF   V    GD    S R
Sbjct: 323  EEAKVVPNNDKDRTYAVSYVPKVAGLHKVTVLFAGQNIERSPFEVNVGMALGDANKVSAR 382

Query: 678  MSHLK-VGSAADIP----INISETDLSLLTATVVPPSGREE--PCLLKRLRNGHVGISFV 836
               L+ VG+ A+ P    I  +      +   +V P GR +     L+   +     ++ 
Sbjct: 383  GPGLEPVGNVANKPTYFDIYTAGAGTGDVAVVIVDPQGRRDTVEVALEDKGDNTFRCTYR 442

Query: 837  PKETGEHLVHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEG--HTFEPAEFII 1010
            P   G H VHV   G  +  SP PV +  +E  + +  R SGRGL        E A+F +
Sbjct: 443  PVMEGPHTVHVAFAGAPITRSPFPVHV--AEACNPNACRASGRGLQPKGVRVKEVADFKV 500

Query: 1011 DTRDAGYGGLSLSIEGPSKVD--INTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGS 1184
             T+ AG G L ++++GP   +  +   +  DG     Y P  PG Y++ I +    +P S
Sbjct: 501  FTKGAGSGELKVTVKGPKGTEEPVKVREAGDGVFECEYYPVVPGKYVVTITWGGYAIPRS 560

Query: 1185 PFSVKVTGEGRVKESITRRQRAPSV--ANVGSHCDLSLKIPEISIQDMTAQVTSPSGKSH 1358
            PF V+V+ E   ++    R   P +    VG   D  ++     +  +   +  PS    
Sbjct: 561  PFEVQVSPEAGAQKV---RAWGPGLETGQVGKSADFVVEAIGTEVGTLGFSIEGPSQAKI 617

Query: 1359 EAEIVEGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPL-GEGGAHKVRAGG 1535
            E +  +  + +  +R+ P E G + V V    + +  SPF   + P   +    KV+A G
Sbjct: 618  ECD--DKGDGSCDVRYWPTEPGEYAVHVICDDEDIRDSPFIAHIQPAPPDCFPDKVKAFG 675

Query: 1536 PGLERAEAGV--PAEFSIWTREAGAGGLAIAVEGPSKAEISFE--DRKDGSCGVAYVVQE 1703
            PGLE     V  PAEF+I  R AG G L +  +      I  +     DG+   +YV  +
Sbjct: 676  PGLEPTGCIVDRPAEFTIDARAAGKGDLKLYAQDADGCPIDIKVIPNGDGTFRCSYVPTK 735

Query: 1704 PGDYEVSVKFNEEHIPDSPFVVPVASPSGDAR-RLTVSSLQESGLKVNQPASFAVSLNGA 1880
            P  + + V +   ++P SPF V V   S   R ++    ++++GLK N+P  F V  + A
Sbjct: 736  PIKHTIIVSWGGVNVPKSPFRVNVGEGSHPERVKVYGPGVEKTGLKANEPTYFTVDCSEA 795

Query: 1881 -KGAIDAKVHSPSGALE------ECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPG 2039
             +G +   +    G +       +  + + D D + V++ P   G Y I V F    IP 
Sbjct: 796  GQGDVSIGIKCAPGVVGPVEADIDFDIIKNDNDTFTVKYTPPGAGHYTIMVLFANQEIPA 855

Query: 2040 SPFKIRVGEPGHGGDPGLVSAYGAGLE--GGVTGSPAEFIVNTSNAGAGALSVTIDGPSK 2213
            SPF I+V +P H  D   V A G GL   G   G P  F V T  AG   L V   G +K
Sbjct: 856  SPFHIKV-DPSH--DASKVKAEGPGLSRTGVEVGKPTHFTVLTKGAGKAKLDVHFAGAAK 912

Query: 2214 VKM-----DCQECPEGYRVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHS 2378
             +              Y V YT +  G+  +++ YGG   +  SPF   V          
Sbjct: 913  GEAVRDFEIIDNHDYSYTVKYTAVQQGNMAVTVTYGGD-PVPKSPFVVNVA--------- 962

Query: 2379 LHETSSVFVDSLTKTXXXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKA- 2555
                                           SKV  +GL  SK  VGQ+ +F+V+   A 
Sbjct: 963  --------------------------PPLDLSKVKVQGLN-SKVAVGQEQAFSVNTRGAG 995

Query: 2556 GNNMLLVGVHGP-RTPCEEILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRV 2732
            G   L V +  P R P    L    G+   +V Y+  ++G Y + + +    +PGSP+ V
Sbjct: 996  GQGQLDVRMTSPSRRPIPCKLEPGGGAEAQAVRYMPPEEGPYKVDITYDGHPVPGSPFAV 1055



 Score =  132 bits (331), Expect = 2e-30
 Identities = 91/311 (29%), Positives = 140/311 (45%), Gaps = 53/311 (17%)
 Frame = +3

Query: 138  VNGLDVTSLR---PFDLVIPFTIKKGEITGEVRMPSGKVAQPAITDNKDGTVTVRYAPSE 308
            V  L  T L+   P    +     +G I   V  PSG V +  +++      T+R+ P E
Sbjct: 2414 VTSLQETGLKVNQPASFAVQLNGARGVIDARVHTPSGAVEECYVSELDSDKHTIRFIPHE 2473

Query: 309  AGLHEMDIRYDNMHIPGSPLQFYVDYVNC----GHVTAYGPGLSHGVVNKPAVFTVNTKD 476
             G+H +D++++  HIPGSP +  V   +     G V+AYGPGL  G     + F VNT++
Sbjct: 2474 NGVHSIDVKFNGAHIPGSPFKIRVGEQSQAGDPGLVSAYGPGLEGGTTGVSSEFIVNTQN 2533

Query: 477  AGEGGLSLAIEGPSKAEISCTDNQDGTCSVSYLPVLPGDYSILVKY-NEQHIPGSPFTAR 653
            AG G LS+ I+GPSK ++ C +  +G   V+Y P+ PG+Y I +KY   QHI GSPF A+
Sbjct: 2534 AGSGALSVTIDGPSKVQLDCRECPEGHV-VTYTPMAPGNYLIAIKYGGPQHIVGSPFKAK 2592

Query: 654  VTG----------------------DDSMR-----------------------MSHLKVG 698
            VTG                        S R                       +S   VG
Sbjct: 2593 VTGPRLSGGHSLHETSTVLVETVTKSSSSRGASYSSIPKFSSDASKVVTRGPGLSQAFVG 2652

Query: 699  SAADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKN 878
                  ++ S+   +++   V  P    E   +K + N    +++  KE G++++ VK  
Sbjct: 2653 QKNSFTVDCSKAGTNMMMVGVHGPKTPCEEVYVKHMGNRVYNVTYTVKEKGDYILIVKWG 2712

Query: 879  GQHVASSPIPV 911
             + V  SP  V
Sbjct: 2713 DESVPGSPFKV 2723


>ref|NP_001159425.1| tripartite motif-containing protein 45 isoform a [Mus musculus].
          Length = 757

 Score = 54.7 bits (130), Expect = 4e-07
 Identities = 34/105 (32%), Positives = 53/105 (50%), Gaps = 11/105 (10%)
 Frame = +3

Query: 936  DASRVRVSGRGLHEGHTFEPAEFIIDTRDA-----GYGGLSLSIE------GPSKVDINT 1082
            D ++  + G  LH     + A F +  +DA     G GG ++ +E        S +    
Sbjct: 398  DPAQCVLQGEDLHRAREKQTASFTLFCKDASGQSMGRGGDNVHVEVVPKDKKDSPIRTVV 457

Query: 1083 EDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTGEGR 1217
            +D +DG+ RV+Y P EPG Y + +   +QHV GSPF+V V  + R
Sbjct: 458  QDNKDGSYRVSYTPKEPGIYTVWVCIREQHVQGSPFNVTVRRKHR 502


>ref|NP_001159424.1| tripartite motif-containing protein 45 isoform b [Mus musculus].
          Length = 580

 Score = 54.7 bits (130), Expect = 4e-07
 Identities = 34/105 (32%), Positives = 53/105 (50%), Gaps = 11/105 (10%)
 Frame = +3

Query: 936  DASRVRVSGRGLHEGHTFEPAEFIIDTRDA-----GYGGLSLSIE------GPSKVDINT 1082
            D ++  + G  LH     + A F +  +DA     G GG ++ +E        S +    
Sbjct: 398  DPAQCVLQGEDLHRAREKQTASFTLFCKDASGQSMGRGGDNVHVEVVPKDKKDSPIRTVV 457

Query: 1083 EDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTGEGR 1217
            +D +DG+ RV+Y P EPG Y + +   +QHV GSPF+V V  + R
Sbjct: 458  QDNKDGSYRVSYTPKEPGIYTVWVCIREQHVQGSPFNVTVRRKHR 502


>ref|NP_919324.2| tripartite motif-containing protein 45 isoform b [Mus musculus].
          Length = 580

 Score = 54.7 bits (130), Expect = 4e-07
 Identities = 34/105 (32%), Positives = 53/105 (50%), Gaps = 11/105 (10%)
 Frame = +3

Query: 936  DASRVRVSGRGLHEGHTFEPAEFIIDTRDA-----GYGGLSLSIE------GPSKVDINT 1082
            D ++  + G  LH     + A F +  +DA     G GG ++ +E        S +    
Sbjct: 398  DPAQCVLQGEDLHRAREKQTASFTLFCKDASGQSMGRGGDNVHVEVVPKDKKDSPIRTVV 457

Query: 1083 EDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTGEGR 1217
            +D +DG+ RV+Y P EPG Y + +   +QHV GSPF+V V  + R
Sbjct: 458  QDNKDGSYRVSYTPKEPGIYTVWVCIREQHVQGSPFNVTVRRKHR 502


  Database: RefSeq49_MP.fasta
    Posted date:  Oct 17, 2011  1:42 PM
  Number of letters in database: 15,617,559
  Number of sequences in database:  30,036
  
Lambda     K      H
   0.318    0.134    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 30036
Number of Hits to DB: 106,302,656
Number of extensions: 3200098
Number of successful extensions: 17624
Number of sequences better than 1.0e-05: 6
Number of HSP's gapped: 16726
Number of HSP's successfully gapped: 54
Length of query: 1029
Length of database: 15,617,559
Length adjustment: 111
Effective length of query: 918
Effective length of database: 12,283,563
Effective search space: 11276310834
Effective search space used: 11276310834
Neighboring words threshold: 12
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 36 (18.5 bits)

BLASTX 2.2.24 [Aug-08-2010]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= 20110601C-007518
         (3088 letters)

Database: RefSeq49_SP.fasta 
           24,897 sequences; 11,343,932 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

Alignment   gi|XP_003134750.1| PREDICTED: filamin-C isoform 4 [Sus scrofa].     1354   0.0  
Alignment   gi|XP_003360191.1| PREDICTED: filamin-C [Sus scrofa].               1354   0.0  
Alignment   gi|XP_003134749.1| PREDICTED: filamin-C isoform 3 [Sus scrofa].     1354   0.0  
Alignment   gi|XP_003134747.1| PREDICTED: filamin-C isoform 1 [Sus scrofa].      799   0.0  
Alignment   gi|XP_003134748.1| PREDICTED: filamin-C isoform 2 [Sus scrofa].      799   0.0  
Alignment   gi|XP_003362247.1| PREDICTED: filamin-A-like, partial [Sus scro...   480   e-135
Alignment   gi|XP_003132317.2| PREDICTED: filamin-B-like [Sus scrofa].           325   1e-88
Alignment   gi|XP_003362207.1| PREDICTED: filamin-A, partial [Sus scrofa].       310   2e-84
Alignment   gi|XP_003361471.1| PREDICTED: tripartite motif-containing prote...    54   7e-07
Alignment   gi|XP_001929378.1| PREDICTED: tripartite motif-containing prote...    54   7e-07

>ref|XP_003134750.1| PREDICTED: filamin-C isoform 4 [Sus scrofa].
          Length = 2607

 Score = 1354 bits (3505), Expect = 0.0
 Identities = 648/879 (73%), Positives = 763/879 (86%), Gaps = 3/879 (0%)
 Frame = +3

Query: 114  APERPLVGVNGLDVTSLRPFDLVIPFTIKKGEITGEVRMPSGKVAQPAITDNKDGTVTVR 293
            A E P+V V  ++ + LRPF+LVIPFT++KGE+TGEVRMPSGK A+P ITDNKDGT+TVR
Sbjct: 1730 ATEEPVVPVESME-SMLRPFNLVIPFTVQKGELTGEVRMPSGKTARPNITDNKDGTITVR 1788

Query: 294  YAPSEAGLHEMDIRYDNMHIPGSPLQFYVDYVNCGHVTAYGPGLSHGVVNKPAVFTVNTK 473
            YAP+E GLH+M I+YD  HIPGSPLQFYVD +N  HV+AYGPGLSHG+VNKPA FT+ TK
Sbjct: 1789 YAPTEKGLHQMGIKYDGNHIPGSPLQFYVDAINSRHVSAYGPGLSHGMVNKPATFTIVTK 1848

Query: 474  DAGEGGLSLAIEGPSKAEISCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTAR 653
            DAGEGGLSLA+EGPSKAEI+C DN+DGTC+VSYLP  PGDYSI+V+++++HIPGSPFTA+
Sbjct: 1849 DAGEGGLSLAVEGPSKAEITCKDNKDGTCTVSYLPTAPGDYSIIVRFDDKHIPGSPFTAK 1908

Query: 654  VTGDDSMRMSHLKVGSAADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISF 833
            +TGDDSMR S L VG++ D+ + I+E+DLS LTA++  PSG EEPCLLKRL N H+GISF
Sbjct: 1909 ITGDDSMRTSQLNVGTSTDVSLKITESDLSQLTASIRAPSGNEEPCLLKRLPNRHIGISF 1968

Query: 834  VPKETGEHLVHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEGHTFEPAEFIID 1013
             PKE GEH+V V+K+G+HV +SP  +++  SEIGDAS+VRV G+GL EG TF+ AEFI+D
Sbjct: 1969 TPKEVGEHVVSVRKSGKHVTNSPFKILVGPSEIGDASKVRVWGKGLSEGQTFQVAEFIVD 2028

Query: 1014 TRDAGYGGLSLSIEGPSKVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFS 1193
            TR+AGYGGL LSIEGPSKVDIN ED+EDGTC+VTYCPTEPG YIINIKFAD+HVPGSPF+
Sbjct: 2029 TRNAGYGGLGLSIEGPSKVDINCEDMEDGTCKVTYCPTEPGTYIINIKFADKHVPGSPFT 2088

Query: 1194 VKVTGEGRVKESITRRQRAPSVANVGSHCDLSLKIP-EISIQDMTAQVTSPSGKSHEAEI 1370
            VKVTGEGR+KESITRR++APS+A +GS CDL+LKIP E S QDMTAQVTSPSGK+  AEI
Sbjct: 2089 VKVTGEGRMKESITRRRQAPSIATIGSTCDLNLKIPGEASSQDMTAQVTSPSGKTEAAEI 2148

Query: 1371 VEGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLER 1550
            VEGE+  Y +RFVP EMG HTV+VKY+GQHVPGSPFQFTVGPLGEGGAHKVRAGG GLER
Sbjct: 2149 VEGEDSAYSVRFVPQEMGPHTVTVKYRGQHVPGSPFQFTVGPLGEGGAHKVRAGGTGLER 2208

Query: 1551 AEAGVPAEFSIWTREAGAGGLAIAVEGPSKAEISFEDRKDGSCGVAYVVQEPGDYEVSVK 1730
              AGVPAEFSIWTREAGAGGL+IAVEGPSKAEI+FEDRKDGSCGV+YVVQEPGDYEVS+K
Sbjct: 2209 GVAGVPAEFSIWTREAGAGGLSIAVEGPSKAEIAFEDRKDGSCGVSYVVQEPGDYEVSIK 2268

Query: 1731 FNEEHIPDSPFVVPVASPSGDARRLTVSSLQESGLKVNQPASFAVSLNGAKGAIDAKVHS 1910
            FN+EHIPDSPFVVPVAS S DARRLTV+SLQE+GLKVNQPASFAV LNGA+G IDA+VH+
Sbjct: 2269 FNDEHIPDSPFVVPVASLSDDARRLTVTSLQETGLKVNQPASFAVQLNGARGVIDARVHT 2328

Query: 1911 PSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPG 2090
            PSGA+EECYV+E+D DK+ +RFIP ENGV+ IDVKFNG HIPGSPFKIRVGE    GDPG
Sbjct: 2329 PSGAVEECYVSELDSDKHTIRFIPHENGVHSIDVKFNGAHIPGSPFKIRVGEQSQAGDPG 2388

Query: 2091 LVSAYGAGLEGGVTGSPAEFIVNTSNAGAGALSVTIDGPSKVKMDCQECPEGYRVTYTPM 2270
            LVSAYG GLEGG TG  +EFIVNT NAG+GALSVTIDGPSKV++DC+ECPEG+ VTYTPM
Sbjct: 2389 LVSAYGPGLEGGTTGVSSEFIVNTLNAGSGALSVTIDGPSKVQLDCRECPEGHVVTYTPM 2448

Query: 2271 APGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSVFVDSLTK--TXXXXXXX 2444
            APG+YLI+IKYGGP HI GSPFKA+VTG RL   HSLHETS+V V+++TK  +       
Sbjct: 2449 APGNYLIAIKYGGPQHIVGSPFKAKVTGPRLSGGHSLHETSTVLVETVTKSSSSRGSSYS 2508

Query: 2445 XXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKAGNNMLLVGVHGPRTPCEEILVKH 2624
                     SKV+ +G GLS+A+VGQK SFTVDCSKAG NM++VGVHGP+TPCEE+ VKH
Sbjct: 2509 SIPKFSSDASKVVTRGPGLSQAFVGQKNSFTVDCSKAGTNMMMVGVHGPKTPCEEVYVKH 2568

Query: 2625 VGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLVP 2741
            VG+R+Y+V+Y +K+KG+Y L+VKWGDE +PGSP++V VP
Sbjct: 2569 VGNRVYNVTYTVKEKGDYILIVKWGDESVPGSPFKVNVP 2607



 Score =  474 bits (1221), Expect = e-134
 Identities = 309/904 (34%), Positives = 455/904 (50%), Gaps = 39/904 (4%)
 Frame = +3

Query: 144  GLDVTSLRPFDLVIPFTIK-----KGEITGEVRMPSGKVAQPAITDNKDGTVTVRYAPSE 308
            GL+ + + P  L + FTI      +G +T ++  P GK  +  I DN DGT TV Y P  
Sbjct: 1528 GLNASGI-PASLPVEFTIDARDAGEGLLTVQILDPEGKPKKANIRDNGDGTYTVSYLPDM 1586

Query: 309  AGLHEMDIRYDNMHIPGSPLQFYV----DYVNCGHVTA-YGPGLSHGVVNKPAVFTVNTK 473
            +G + + I+Y    IP SP + +     D   C    A  GP +    + +  V TV+ K
Sbjct: 1587 SGRYTITIKYGGDEIPYSPFRIHALPTGDASKCLVTGACLGPRIQ---IGEETVITVDAK 1643

Query: 474  DAGEGGLSLAIEGPSKAE--ISCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFT 647
             AG+G ++  +  P  AE  +   +N DGT  + Y    PG Y I +++  +HIP SPF 
Sbjct: 1644 AAGKGKVTCTVSTPDGAELDVDVVENHDGTFDIYYTAPEPGKYVITIRFGGEHIPNSPFH 1703

Query: 648  ARVTG-----------DDSMRMSHLKVGSAADIPINISETDL-------------SLLTA 755
              V+              ++    L+      +P+   E+ L               LT 
Sbjct: 1704 VLVSSAAGRGWREAPQPRTVLSPLLQATEEPVVPVESMESMLRPFNLVIPFTVQKGELTG 1763

Query: 756  TVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNGQHVASSPIPVVISQSEIG 935
             V  PSG+     +   ++G + + + P E G H + +K +G H+  SP+   +   +  
Sbjct: 1764 EVRMPSGKTARPNITDNKDGTITVRYAPTEKGLHQMGIKYDGNHIPGSPLQFYV---DAI 1820

Query: 936  DASRVRVSGRGLHEGHTFEPAEFIIDTRDAGYGGLSLSIEGPSKVDINTEDLEDGTCRVT 1115
            ++  V   G GL  G   +PA F I T+DAG GGLSL++EGPSK +I  +D +DGTC V+
Sbjct: 1821 NSRHVSAYGPGLSHGMVNKPATFTIVTKDAGEGGLSLAVEGPSKAEITCKDNKDGTCTVS 1880

Query: 1116 YCPTEPGNYIINIKFADQHVPGSPFSVKVTGEGRVKESITRRQRAPSVANVGSHCDLSLK 1295
            Y PT PG+Y I ++F D+H+PGSPF+ K+TG+  ++          S  NVG+  D+SLK
Sbjct: 1881 YLPTAPGDYSIIVRFDDKHIPGSPFTAKITGDDSMR---------TSQLNVGTSTDVSLK 1931

Query: 1296 IPEISIQDMTAQVTSPSGKSHEAEIVEGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSP 1475
            I E  +  +TA + +PSG      +    N    I F P E+G H VSV+  G+HV  SP
Sbjct: 1932 ITESDLSQLTASIRAPSGNEEPCLLKRLPNRHIGISFTPKEVGEHVVSVRKSGKHVTNSP 1991

Query: 1476 FQFTVGPLGEGGAHKVRAGGPGLERAEAGVPAEFSIWTREAGAGGLAIAVEGPSKAEISF 1655
            F+  VGP   G A KVR  G GL   +    AEF + TR AG GGL +++EGPSK +I+ 
Sbjct: 1992 FKILVGPSEIGDASKVRVWGKGLSEGQTFQVAEFIVDTRNAGYGGLGLSIEGPSKVDINC 2051

Query: 1656 EDRKDGSCGVAYVVQEPGDYEVSVKFNEEHIPDSPFVVPVASPSGDARRLTVSSLQESGL 1835
            ED +DG+C V Y   EPG Y +++KF ++H+P SPF V V         +T      S  
Sbjct: 2052 EDMEDGTCKVTYCPTEPGTYIINIKFADKHVPGSPFTVKVTGEGRMKESITRRRQAPSIA 2111

Query: 1836 KVNQPASFAVSLNGAKGAID--AKVHSPSGALEECYVTEIDQDKYAVRFIPRENGVYLID 2009
             +       + + G   + D  A+V SPSG  E   + E +   Y+VRF+P+E G + + 
Sbjct: 2112 TIGSTCDLNLKIPGEASSQDMTAQVTSPSGKTEAAEIVEGEDSAYSVRFVPQEMGPHTVT 2171

Query: 2010 VKFNGTHIPGSPFKIRVGEPGHGGDPGLVSAYGAGLEGGVTGSPAEFIVNTSNAGAGALS 2189
            VK+ G H+PGSPF+  VG  G GG    V A G GLE GV G PAEF + T  AGAG LS
Sbjct: 2172 VKYRGQHVPGSPFQFTVGPLGEGG-AHKVRAGGTGLERGVAGVPAEFSIWTREAGAGGLS 2230

Query: 2190 VTIDGPSKVKMDCQECPEG-YRVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLV 2366
            + ++GPSK ++  ++  +G   V+Y    PG Y +SIK+    HI  SPF   V     +
Sbjct: 2231 IAVEGPSKAEIAFEDRKDGSCGVSYVVQEPGDYEVSIKFNDE-HIPDSPFVVPVAS---L 2286

Query: 2367 SNHSLHETSSVFVDSLTKTXXXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDC 2546
            S+ +   T    V SL +T                        GL    V Q  SF V  
Sbjct: 2287 SDDARRLT----VTSLQET------------------------GLK---VNQPASFAVQL 2315

Query: 2547 SKAGNNMLLVGVHGPRTPCEEILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPY 2726
            + A   ++   VH P    EE  V  + S  +++ ++  + G +++ VK+   HIPGSP+
Sbjct: 2316 NGA-RGVIDARVHTPSGAVEECYVSELDSDKHTIRFIPHENGVHSIDVKFNGAHIPGSPF 2374

Query: 2727 RVLV 2738
            ++ V
Sbjct: 2375 KIRV 2378



 Score =  358 bits (919), Expect = 1e-98
 Identities = 278/885 (31%), Positives = 414/885 (46%), Gaps = 40/885 (4%)
 Frame = +3

Query: 204  GEITGEVRMPSGK--VAQPAITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFY 377
            G++   +  P G+    + A+ D  D T    Y P   G H + + +    I  SP   +
Sbjct: 388  GDVAVVIVDPQGRRDTVEVALEDKGDSTFRCTYRPVMEGPHTVHVAFAGAPITRSPFPVH 447

Query: 378  V-DYVNCGHVTAYGPGLS-HGV-VNKPAVFTVNTKDAGEGGLSLAIEGPSKAE--ISCTD 542
            V +  N     A G GL   GV V + A F V TK AG G L + ++GP   E  +   D
Sbjct: 448  VAEACNPNACRASGRGLQPKGVRVKEVADFKVFTKGAGSGELKVTVKGPKGTEEPVKVRD 507

Query: 543  NQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARVTGDDSMR--------MSHLKVG 698
              DG     Y PV+PG Y + + +    IP SPF  +V+ +  M+        +   +VG
Sbjct: 508  AGDGVFECEYYPVVPGKYVVTITWGGYAIPRSPFEVQVSPEAGMQKVRAWGPGLETGQVG 567

Query: 699  SAADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKN 878
             +AD  +    T++  L  ++  PS  +  C  K   +G   + + P E GE+ VHV  +
Sbjct: 568  KSADFVVEAIGTEVGTLGFSIEGPSQAKIECDDK--GDGSCDVRYWPTEPGEYAVHVICD 625

Query: 879  GQHVASSPIPVVISQSEIG-DASRVRVSGRGLHEGHTF--EPAEFIIDTRDAGYGGLSLS 1049
             + +  SP    I  +       +V+  G GL        +PAEF ID R AG G L L 
Sbjct: 626  DEDIRDSPFIAHIQPAPPDCFPDKVKAFGPGLEPTGCIVDKPAEFTIDARAAGKGDLKLY 685

Query: 1050 IEGPS--KVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTGEGRVK 1223
             +      +DI      DGT R +Y PT+P  + I I +   +VP SPF V V GEG   
Sbjct: 686  AQDADGCPIDIKVIPNGDGTFRCSYVPTKPIKHTIIISWGGVNVPKSPFRVNV-GEGSHP 744

Query: 1224 ESITRRQRAPSVANVGSHCD----LSLKIPEISIQDMT------AQVTSPSGKSHEAEIV 1373
            E +  +   P V   G   +     ++   E    D++        V  P+    + +I+
Sbjct: 745  ERV--KVYGPGVEKTGLKANEPTYFTVDCSEAGQGDVSIGIKCAPGVVGPAEADIDFDII 802

Query: 1374 EGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLER- 1550
            + +N T+ +++ P   G +T+ V +  Q +P SPF   V P  +  A KV+A GPGL R 
Sbjct: 803  KNDNDTFTVKYTPPGAGRYTIMVLFANQEIPASPFHIKVDPSHD--ASKVKAEGPGLNRT 860

Query: 1551 -AEAGVPAEFSIWTREAGAGGLAIAVEGPSKAEI--SFE--DRKDGSCGVAYVVQEPGDY 1715
              E G P  F++ T+ AG   L +   G +K E    FE  D  D S  V Y   + G+ 
Sbjct: 861  GVEVGKPTHFTVLTKGAGKAKLDVHFAGAAKGEAVRDFEIIDNHDYSYTVKYTAVQQGNM 920

Query: 1716 EVSVKFNEEHIPDSPFVVPVASPSGDARRLTVSSLQESGLKVNQPASFAVSLNGA--KGA 1889
             V+V +  + +P SPFVV VA P  D  ++ V  L  S + V Q  +F+V+  GA  +G 
Sbjct: 921  AVTVTYGGDPVPKSPFVVNVAPPL-DLSKVKVQGL-NSKVAVGQEQAFSVNTRGAGGQGQ 978

Query: 1890 IDAKVHSPSGALEECYVTE-IDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGE 2066
            +D ++ SPS     C +      D  AVR++P E G Y +D+ ++G  +PGSPF +    
Sbjct: 979  LDVRMTSPSRRPIPCKLEPGGGADAQAVRYMPPEEGPYKVDITYDGHPVPGSPFAVEGVL 1038

Query: 2067 PGHGGDPGLVSAYGAGLEGGVTGSPAEFIVNTSNAGAGALSVTIDGPSKVKMDCQECPEG 2246
            P    DP  V AYG GL+GG+ G+PA F ++T  AG G L +T++GP + K++CQ+  +G
Sbjct: 1039 P---PDPSKVCAYGPGLKGGLVGTPAPFSIDTKGAGTGGLGLTVEGPCEAKIECQDNGDG 1095

Query: 2247 -YRVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSVFVDSLTKT 2423
               V+Y P  PG Y I+I +    HI GSPFKA +                VF       
Sbjct: 1096 SCAVSYLPTEPGEYTINILF-AEAHIPGSPFKATI--------------RPVF------- 1133

Query: 2424 XXXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKAGNNMLLVGVHGPRTPC 2603
                            SKV A G GL +   G+  +FTVDCS+AG   L + +       
Sbjct: 1134 --------------DPSKVRASGPGLERGKAGEAATFTVDCSEAGEAELTIEILSDAGVK 1179

Query: 2604 EEILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLV 2738
             E+L+ +     Y ++Y     G YT+ +K+G   +P  P RV V
Sbjct: 1180 AEVLIHNNADGTYHITYSPAFPGTYTITIKYGGHPVPKFPTRVHV 1224



 Score =  327 bits (838), Expect = 2e-89
 Identities = 248/889 (27%), Positives = 404/889 (45%), Gaps = 43/889 (4%)
 Frame = +3

Query: 201  KGEITGEVRMPSGKVAQPAITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFYV 380
            + E+T E+   +G  A+  I +N DGT  + Y+P+  G + + I+Y    +P  P + +V
Sbjct: 1165 EAELTIEILSDAGVKAEVLIHNNADGTYHITYSPAFPGTYTITIKYGGHPVPKFPTRVHV 1224

Query: 381  D-YVNCGHVTAYGPGLS-HGVVNKPAV-FTVNTKD---AGEGGLSLAIEGPS--KAEISC 536
               V+   V   GPG+  HGV+ +    FTV+ +     G   ++  +  PS  K +   
Sbjct: 1225 QPAVDTSGVKVSGPGVEPHGVLREVTTEFTVDARSLTATGGNHVTARVLNPSGAKTDTYV 1284

Query: 537  TDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARVT-GDDSMRMSHL-------K 692
            TDN DGT  V Y     G + + V Y++  +P SPF   VT G D  R+           
Sbjct: 1285 TDNGDGTYRVQYTAYEEGVHLVEVLYDDVAVPKSPFRVGVTEGCDPTRVRAFGPGLEGGL 1344

Query: 693  VGSAADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVK 872
            V  A    +         L   +  PS  +  C  K  ++G   + ++P   G++ V++ 
Sbjct: 1345 VNKANRFTVETRGAGTGGLGLAIEGPSEAKMSC--KDNKDGSCTVEYIPFTPGDYDVNIT 1402

Query: 873  KNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEG-HTFEPAEFIIDTRDAGYGGLSLS 1049
              G+ +  SP  V +   ++ D  +V+ SG GL  G     P  F +D   AG   L ++
Sbjct: 1403 FGGRPIPGSPFRVPV--KDVVDPGKVKCSGPGLGAGVRARVPQTFTVDCSQAGRAPLQVA 1460

Query: 1050 IEGPSKV--DINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTGEGRVK 1223
            +  P+ V   +   D  DGT  V Y P   G Y + +K+ADQ VP SPF +KV       
Sbjct: 1461 VLSPTGVAEPVEVRDNGDGTHTVHYTPATDGPYTVAVKYADQEVPRSPFKIKVL---PAH 1517

Query: 1224 ESITRRQRAPSVANVGSHCDLSLKIPEISIQD-----MTAQVTSPSGKSHEAEIVEGENH 1388
            ++   R   P +   G    L ++   I  +D     +T Q+  P GK  +A I +  + 
Sbjct: 1518 DASKVRASGPGLNASGIPASLPVEF-TIDARDAGEGLLTVQILDPEGKPKKANIRDNGDG 1576

Query: 1389 TYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLERAEAGVP 1568
            TY + ++P   G +T+++KY G  +P SPF+    P G+     V     G  R + G  
Sbjct: 1577 TYTVSYLPDMSGRYTITIKYGGDEIPYSPFRIHALPTGDASKCLVTGACLG-PRIQIGEE 1635

Query: 1569 AEFSIWTREAGAGGLAIAVEGPSKAEISFE--DRKDGSCGVAYVVQEPGDYEVSVKFNEE 1742
               ++  + AG G +   V  P  AE+  +  +  DG+  + Y   EPG Y ++++F  E
Sbjct: 1636 TVITVDAKAAGKGKVTCTVSTPDGAELDVDVVENHDGTFDIYYTAPEPGKYVITIRFGGE 1695

Query: 1743 HIPDSPFVVPVASPSG-------DARRLTVSSLQ---------ESGLKVNQPASFAVSLN 1874
            HIP+SPF V V+S +G         R +    LQ         ES   + +P +  +   
Sbjct: 1696 HIPNSPFHVLVSSAAGRGWREAPQPRTVLSPLLQATEEPVVPVESMESMLRPFNLVIPFT 1755

Query: 1875 GAKGAIDAKVHSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKI 2054
              KG +  +V  PSG      +T+       VR+ P E G++ + +K++G HIPGSP + 
Sbjct: 1756 VQKGELTGEVRMPSGKTARPNITDNKDGTITVRYAPTEKGLHQMGIKYDGNHIPGSPLQF 1815

Query: 2055 RVGEPGHGGDPGLVSAYGAGLEGGVTGSPAEFIVNTSNAGAGALSVTIDGPSKVKMDCQE 2234
             V       +   VSAYG GL  G+   PA F + T +AG G LS+ ++GPSK ++ C++
Sbjct: 1816 YV----DAINSRHVSAYGPGLSHGMVNKPATFTIVTKDAGEGGLSLAVEGPSKAEITCKD 1871

Query: 2235 CPEG-YRVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSVFVDS 2411
              +G   V+Y P APG Y I +++    HI GSPF A++TG                 D 
Sbjct: 1872 NKDGTCTVSYLPTAPGDYSIIVRFDDK-HIPGSPFTAKITG-----------------DD 1913

Query: 2412 LTKTXXXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKAGNNMLLVGVHGP 2591
              +T                          S+  VG     ++  +++  + L   +  P
Sbjct: 1914 SMRT--------------------------SQLNVGTSTDVSLKITESDLSQLTASIRAP 1947

Query: 2592 RTPCEEILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLV 2738
                E  L+K + +R   +S+  K+ GE+ + V+   +H+  SP+++LV
Sbjct: 1948 SGNEEPCLLKRLPNRHIGISFTPKEVGEHVVSVRKSGKHVTNSPFKILV 1996



 Score =  306 bits (783), Expect = 6e-83
 Identities = 267/894 (29%), Positives = 406/894 (45%), Gaps = 48/894 (5%)
 Frame = +3

Query: 201  KGEITGEVRMPSGKVAQPAITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFYV 380
            KG++    +   G      +  N DGT    Y P++   H + I +  +++P SP +  V
Sbjct: 679  KGDLKLYAQDADGCPIDIKVIPNGDGTFRCSYVPTKPIKHTIIISWGGVNVPKSPFRVNV 738

Query: 381  -DYVNCGHVTAYGPGLSHG--VVNKPAVFTVNTKDAGEGGLSLAIE------GPSKAEI- 530
             +  +   V  YGPG+       N+P  FTV+  +AG+G +S+ I+      GP++A+I 
Sbjct: 739  GEGSHPERVKVYGPGVEKTGLKANEPTYFTVDCSEAGQGDVSIGIKCAPGVVGPAEADID 798

Query: 531  -SCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARVTGDDSMRMSHLKVGSAA 707
                 N + T +V Y P   G Y+I+V +  Q IP SPF  +V  D S   S +K   A 
Sbjct: 799  FDIIKNDNDTFTVKYTPPGAGRYTIMVLFANQEIPASPFHIKV--DPSHDASKVK---AE 853

Query: 708  DIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVG-----------------ISFV 836
               +N +  ++   T   V   G  +  L         G                 + + 
Sbjct: 854  GPGLNRTGVEVGKPTHFTVLTKGAGKAKLDVHFAGAAKGEAVRDFEIIDNHDYSYTVKYT 913

Query: 837  PKETGEHLVHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEGHTFEPAEFIIDT 1016
              + G   V V   G  V  SP   V++ +   D S+V+V G         E A F ++T
Sbjct: 914  AVQQGNMAVTVTYGGDPVPKSPF--VVNVAPPLDLSKVKVQGLNSKVAVGQEQA-FSVNT 970

Query: 1017 RDA-GYGGLSLSIEGPSKVDINTEDLEDG----TCRVTYCPTEPGNYIINIKFADQHVPG 1181
            R A G G L + +  PS+  I  + LE G       V Y P E G Y ++I +    VPG
Sbjct: 971  RGAGGQGQLDVRMTSPSRRPIPCK-LEPGGGADAQAVRYMPPEEGPYKVDITYDGHPVPG 1029

Query: 1182 SPFSVKVTGEGRVKESITR-RQRAPSVAN--VGSHCDLSLKIPEISIQDMTAQVTSPSGK 1352
            SPF+V    EG +    ++     P +    VG+    S+         +   V  P   
Sbjct: 1030 SPFAV----EGVLPPDPSKVCAYGPGLKGGLVGTPAPFSIDTKGAGTGGLGLTVEGPCEA 1085

Query: 1353 SHEAEIVEGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAG 1532
              E +  +  + +  + ++P E G +T+++ +   H+PGSPF+ T+ P+ +    KVRA 
Sbjct: 1086 KIECQ--DNGDGSCAVSYLPTEPGEYTINILFAEAHIPGSPFKATIRPVFD--PSKVRAS 1141

Query: 1533 GPGLERAEAGVPAEFSIWTREAGAGGLAIAV--EGPSKAEISFEDRKDGSCGVAYVVQEP 1706
            GPGLER +AG  A F++   EAG   L I +  +   KAE+   +  DG+  + Y    P
Sbjct: 1142 GPGLERGKAGEAATFTVDCSEAGEAELTIEILSDAGVKAEVLIHNNADGTYHITYSPAFP 1201

Query: 1707 GDYEVSVKFNEEHIPDSPFVVPVASPSGDARRLTVS--SLQESGLKVNQPASFAV---SL 1871
            G Y +++K+    +P  P  V V  P+ D   + VS   ++  G+       F V   SL
Sbjct: 1202 GTYTITIKYGGHPVPKFPTRVHV-QPAVDTSGVKVSGPGVEPHGVLREVTTEFTVDARSL 1260

Query: 1872 NGAKG-AIDAKVHSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPF 2048
                G  + A+V +PSGA  + YVT+     Y V++   E GV+L++V ++   +P SPF
Sbjct: 1261 TATGGNHVTARVLNPSGAKTDTYVTDNGDGTYRVQYTAYEEGVHLVEVLYDDVAVPKSPF 1320

Query: 2049 KIRVGEPGHGGDPGLVSAYGAGLEGGVTGSPAEFIVNTSNAGAGALSVTIDGPSKVKMDC 2228
            ++ V E   G DP  V A+G GLEGG+      F V T  AG G L + I+GPS+ KM C
Sbjct: 1321 RVGVTE---GCDPTRVRAFGPGLEGGLVNKANRFTVETRGAGTGGLGLAIEGPSEAKMSC 1377

Query: 2229 QECPEG-YRVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSVFV 2405
            ++  +G   V Y P  PG Y ++I +GG   I GSPF+  V                  V
Sbjct: 1378 KDNKDGSCTVEYIPFTPGDYDVNITFGG-RPIPGSPFRVPVKD---------------VV 1421

Query: 2406 DSLTKTXXXXXXXXXXXXXXXXSKVLAKGLGLS---KAYVGQKGSFTVDCSKAGNNMLLV 2576
            D                      KV   G GL    +A V Q  +FTVDCS+AG   L V
Sbjct: 1422 D--------------------PGKVKCSGPGLGAGVRARVPQ--TFTVDCSQAGRAPLQV 1459

Query: 2577 GVHGPRTPCEEILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLV 2738
             V  P    E + V+  G   ++V Y     G YT+ VK+ D+ +P SP+++ V
Sbjct: 1460 AVLSPTGVAEPVEVRDNGDGTHTVHYTPATDGPYTVAVKYADQEVPRSPFKIKV 1513



 Score =  298 bits (763), Expect = 1e-80
 Identities = 247/895 (27%), Positives = 384/895 (42%), Gaps = 50/895 (5%)
 Frame = +3

Query: 204  GEITGEVRMPSGKVAQPAITDN--KDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFY 377
            GE+   +  P G   +  +  N  KD T  V Y P  AGLH++ + +   +I  SP +  
Sbjct: 288  GEVLVYIEDPEGHTEEAKVVPNNDKDRTYAVSYVPKVAGLHKVTVLFAGQNIERSPFEVN 347

Query: 378  VDYV--NCGHVTAYGPGLS--HGVVNKPAVFTVNTKDAGEGGLSLAIEGP----SKAEIS 533
            V     +   V+A GPGL     V NKP  F + T  AG G +++ I  P       E++
Sbjct: 348  VGMALGDANKVSARGPGLEPVGNVANKPTYFDIYTAGAGTGDVAVVIVDPQGRRDTVEVA 407

Query: 534  CTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARV----------TGDDSMRMS 683
              D  D T   +Y PV+ G +++ V +    I  SPF   V               ++  
Sbjct: 408  LEDKGDSTFRCTYRPVMEGPHTVHVAFAGAPITRSPFPVHVAEACNPNACRASGRGLQPK 467

Query: 684  HLKVGSAADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLV 863
             ++V   AD  +         L  TV  P G EEP  ++   +G     + P   G+++V
Sbjct: 468  GVRVKEVADFKVFTKGAGSGELKVTVKGPKGTEEPVKVRDAGDGVFECEYYPVVPGKYVV 527

Query: 864  HVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEGHTFEPAEFIIDTRDAGYGGLS 1043
             +   G  +  SP  V +S        +VR  G GL  G   + A+F+++      G L 
Sbjct: 528  TITWGGYAIPRSPFEVQVSPE--AGMQKVRAWGPGLETGQVGKSADFVVEAIGTEVGTLG 585

Query: 1044 LSIEGPSKVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTGEGRVK 1223
             SIEGPS+  I  +D  DG+C V Y PTEPG Y +++   D+ +  SPF   +  +    
Sbjct: 586  FSIEGPSQAKIECDDKGDGSCDVRYWPTEPGEYAVHVICDDEDIRDSPFIAHI--QPAPP 643

Query: 1224 ESITRRQRA------PSVANVGSHCDLSLKIPEISIQDMTAQVTSPSGKSHEAEIVEGEN 1385
            +    + +A      P+   V    + ++        D+        G   + +++   +
Sbjct: 644  DCFPDKVKAFGPGLEPTGCIVDKPAEFTIDARAAGKGDLKLYAQDADGCPIDIKVIPNGD 703

Query: 1386 HTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAH--KVRAGGPGLERA-- 1553
             T+   +VP +   HT+ + + G +VP SPF+  VG     G+H  +V+  GPG+E+   
Sbjct: 704  GTFRCSYVPTKPIKHTIIISWGGVNVPKSPFRVNVGE----GSHPERVKVYGPGVEKTGL 759

Query: 1554 EAGVPAEFSIWTREAGAGGLAIAVE------GPSKAEISFEDRK--DGSCGVAYVVQEPG 1709
            +A  P  F++   EAG G ++I ++      GP++A+I F+  K  + +  V Y     G
Sbjct: 760  KANEPTYFTVDCSEAGQGDVSIGIKCAPGVVGPAEADIDFDIIKNDNDTFTVKYTPPGAG 819

Query: 1710 DYEVSVKFNEEHIPDSPFVVPVASPSGDARRLTVS--SLQESGLKVNQPASFAVSLNGAK 1883
             Y + V F  + IP SPF + V  PS DA ++      L  +G++V +P  F V   GA 
Sbjct: 820  RYTIMVLFANQEIPASPFHIKV-DPSHDASKVKAEGPGLNRTGVEVGKPTHFTVLTKGA- 877

Query: 1884 GAIDAKVH----SPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFK 2051
            G     VH    +   A+ +  + +     Y V++   + G   + V + G  +P SPF 
Sbjct: 878  GKAKLDVHFAGAAKGEAVRDFEIIDNHDYSYTVKYTAVQQGNMAVTVTYGGDPVPKSPFV 937

Query: 2052 IRVGEPGHGGDPGLVSAYGAGLEGGVTGSPAEFIVNTSNAGA-GALSVTIDGPSKVKMDC 2228
            + V  P    D   V   G   +  V G    F VNT  AG  G L V +  PS+  + C
Sbjct: 938  VNVAPP---LDLSKVKVQGLNSKVAV-GQEQAFSVNTRGAGGQGQLDVRMTSPSRRPIPC 993

Query: 2229 QECPEG----YRVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSS 2396
            +  P G      V Y P   G Y + I Y G + + GSPF                    
Sbjct: 994  KLEPGGGADAQAVRYMPPEEGPYKVDITYDG-HPVPGSPFAVE----------------- 1035

Query: 2397 VFVDSLTKTXXXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKAGNNMLLV 2576
                                     SKV A G GL    VG    F++D   AG   L +
Sbjct: 1036 ------------------GVLPPDPSKVCAYGPGLKGGLVGTPAPFSIDTKGAGTGGLGL 1077

Query: 2577 GVHGPRTPCE-EILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLV 2738
             V G   PCE +I  +  G    +VSYL  + GEYT+ + + + HIPGSP++  +
Sbjct: 1078 TVEG---PCEAKIECQDNGDGSCAVSYLPTEPGEYTINILFAEAHIPGSPFKATI 1129



 Score =  274 bits (700), Expect = 2e-73
 Identities = 243/873 (27%), Positives = 374/873 (42%), Gaps = 40/873 (4%)
 Frame = +3

Query: 264  DNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFYVDYV--NC--GHVTAYGPGLSH 431
            D  DG+  VRY P+E G + + +  D+  I  SP   ++     +C    V A+GPGL  
Sbjct: 600  DKGDGSCDVRYWPTEPGEYAVHVICDDEDIRDSPFIAHIQPAPPDCFPDKVKAFGPGLEP 659

Query: 432  G--VVNKPAVFTVNTKDAGEGGLSLAIEGPSKA--EISCTDNQDGTCSVSYLPVLPGDYS 599
               +V+KPA FT++ + AG+G L L  +       +I    N DGT   SY+P  P  ++
Sbjct: 660  TGCIVDKPAEFTIDARAAGKGDLKLYAQDADGCPIDIKVIPNGDGTFRCSYVPTKPIKHT 719

Query: 600  ILVKYNEQHIPGSPFTARVTGDDS-----------MRMSHLKVGSAADIPINISET---D 737
            I++ +   ++P SPF   V G+ S           +  + LK        ++ SE    D
Sbjct: 720  IIISWGGVNVPKSPFRVNV-GEGSHPERVKVYGPGVEKTGLKANEPTYFTVDCSEAGQGD 778

Query: 738  LSL---LTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNGQHVASSPIP 908
            +S+       VV P+  +    + +  N    + + P   G + + V    Q + +SP  
Sbjct: 779  VSIGIKCAPGVVGPAEADIDFDIIKNDNDTFTVKYTPPGAGRYTIMVLFANQEIPASPFH 838

Query: 909  VVISQSEIGDASRVRVSGRGLHEG--HTFEPAEFIIDTRDAGYGGLSLSIEGPSKV---- 1070
            + +  S   DAS+V+  G GL+       +P  F + T+ AG   L +   G +K     
Sbjct: 839  IKVDPSH--DASKVKAEGPGLNRTGVEVGKPTHFTVLTKGAGKAKLDVHFAGAAKGEAVR 896

Query: 1071 DINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTGEGRVKESITRRQRA 1250
            D    D  D +  V Y   + GN  + + +    VP SPF V V     +  S  + Q  
Sbjct: 897  DFEIIDNHDYSYTVKYTAVQQGNMAVTVTYGGDPVPKSPFVVNVAPP--LDLSKVKVQGL 954

Query: 1251 PSVANVGSHCDLSLKIPEISIQ-DMTAQVTSPSGKSHEAEIVEGEN-HTYCIRFVPAEMG 1424
             S   VG     S+       Q  +  ++TSPS +    ++  G       +R++P E G
Sbjct: 955  NSKVAVGQEQAFSVNTRGAGGQGQLDVRMTSPSRRPIPCKLEPGGGADAQAVRYMPPEEG 1014

Query: 1425 MHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLERAEAGVPAEFSIWTREAGA 1604
             + V + Y G  VPGSPF   V  +      KV A GPGL+    G PA FSI T+ AG 
Sbjct: 1015 PYKVDITYDGHPVPGSPF--AVEGVLPPDPSKVCAYGPGLKGGLVGTPAPFSIDTKGAGT 1072

Query: 1605 GGLAIAVEGPSKAEISFEDRKDGSCGVAYVVQEPGDYEVSVKFNEEHIPDSPFVVPVASP 1784
            GGL + VEGP +A+I  +D  DGSC V+Y+  EPG+Y +++ F E HIP SPF   +  P
Sbjct: 1073 GGLGLTVEGPCEAKIECQDNGDGSCAVSYLPTEPGEYTINILFAEAHIPGSPFKATI-RP 1131

Query: 1785 SGDARRLTVSSLQESGLKVNQPASFAVSLNGA-KGAIDAKVHSPSGALEECYVTEIDQDK 1961
              D  ++  S       K  + A+F V  + A +  +  ++ S +G   E  +       
Sbjct: 1132 VFDPSKVRASGPGLERGKAGEAATFTVDCSEAGEAELTIEILSDAGVKAEVLIHNNADGT 1191

Query: 1962 YAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPGLVSAYGAGLEGGVTGSP 2141
            Y + + P   G Y I +K+ G  +P  P ++ V +P        VS  G    G +    
Sbjct: 1192 YHITYSPAFPGTYTITIKYGGHPVPKFPTRVHV-QPAVDTSGVKVSGPGVEPHGVLREVT 1250

Query: 2142 AEFIVNTSN---AGAGALSVTIDGPSKVKMDCQECPEG---YRVTYTPMAPGSYLISIKY 2303
             EF V+  +    G   ++  +  PS  K D      G   YRV YT    G +L+ + Y
Sbjct: 1251 TEFTVDARSLTATGGNHVTARVLNPSGAKTDTYVTDNGDGTYRVQYTAYEEGVHLVEVLY 1310

Query: 2304 GGPYHIGGSPFKARVTGHRLVSNHSLHETSSVFVDSLTKTXXXXXXXXXXXXXXXXSKVL 2483
                 +  SPF+  VT                                        ++V 
Sbjct: 1311 -DDVAVPKSPFRVGVT-----------------------------------EGCDPTRVR 1334

Query: 2484 AKGLGLSKAYVGQKGSFTVDCSKAGNNMLLVGVHGPRTPCEEILVKHVGSRLYSVSYLLK 2663
            A G GL    V +   FTV+   AG   L + + GP            GS   +V Y+  
Sbjct: 1335 AFGPGLEGGLVNKANRFTVETRGAGTGGLGLAIEGPSEAKMSCKDNKDGS--CTVEYIPF 1392

Query: 2664 DKGEYTLVVKWGDEHIPGSPYRVLVP*ALCPGQ 2762
              G+Y + + +G   IPGSP+RV V   + PG+
Sbjct: 1393 TPGDYDVNITFGGRPIPGSPFRVPVKDVVDPGK 1425



 Score =  236 bits (602), Expect = 6e-62
 Identities = 237/840 (28%), Positives = 367/840 (43%), Gaps = 47/840 (5%)
 Frame = +3

Query: 354  PGSPLQFYVDYVNCGHVTAYGPGLSH--GVVNKPAVFTVNTKDAGEGGLSLAIEGP---- 515
            PG+P++     +N     AYGPG+      V +PA FTV T DAG G + + IE P    
Sbjct: 244  PGAPVRS--KQLNPKKAIAYGPGIEPQGNTVLQPAHFTVQTVDAGVGEVLVYIEDPEGHT 301

Query: 516  SKAEISCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARV---TGDD---SMR 677
             +A++   +++D T +VSY+P + G + + V +  Q+I  SPF   V    GD    S R
Sbjct: 302  EEAKVVPNNDKDRTYAVSYVPKVAGLHKVTVLFAGQNIERSPFEVNVGMALGDANKVSAR 361

Query: 678  MSHLK-VGSAADIP----INISETDLSLLTATVVPPSGREE--PCLLKRLRNGHVGISFV 836
               L+ VG+ A+ P    I  +      +   +V P GR +     L+   +     ++ 
Sbjct: 362  GPGLEPVGNVANKPTYFDIYTAGAGTGDVAVVIVDPQGRRDTVEVALEDKGDSTFRCTYR 421

Query: 837  PKETGEHLVHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEG--HTFEPAEFII 1010
            P   G H VHV   G  +  SP PV +  +E  + +  R SGRGL        E A+F +
Sbjct: 422  PVMEGPHTVHVAFAGAPITRSPFPVHV--AEACNPNACRASGRGLQPKGVRVKEVADFKV 479

Query: 1011 DTRDAGYGGLSLSIEGPSKVD--INTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGS 1184
             T+ AG G L ++++GP   +  +   D  DG     Y P  PG Y++ I +    +P S
Sbjct: 480  FTKGAGSGELKVTVKGPKGTEEPVKVRDAGDGVFECEYYPVVPGKYVVTITWGGYAIPRS 539

Query: 1185 PFSVKVTGEGRVKESITRRQRAPSV--ANVGSHCDLSLKIPEISIQDMTAQVTSPSGKSH 1358
            PF V+V+ E  +++    R   P +    VG   D  ++     +  +   +  PS    
Sbjct: 540  PFEVQVSPEAGMQKV---RAWGPGLETGQVGKSADFVVEAIGTEVGTLGFSIEGPSQAKI 596

Query: 1359 EAEIVEGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPL-GEGGAHKVRAGG 1535
            E +  +  + +  +R+ P E G + V V    + +  SPF   + P   +    KV+A G
Sbjct: 597  ECD--DKGDGSCDVRYWPTEPGEYAVHVICDDEDIRDSPFIAHIQPAPPDCFPDKVKAFG 654

Query: 1536 PGLERAEAGV--PAEFSIWTREAGAGGLAIAVEGPSKAEISFE--DRKDGSCGVAYVVQE 1703
            PGLE     V  PAEF+I  R AG G L +  +      I  +     DG+   +YV  +
Sbjct: 655  PGLEPTGCIVDKPAEFTIDARAAGKGDLKLYAQDADGCPIDIKVIPNGDGTFRCSYVPTK 714

Query: 1704 PGDYEVSVKFNEEHIPDSPFVVPVASPSGDAR-RLTVSSLQESGLKVNQPASFAVSLNGA 1880
            P  + + + +   ++P SPF V V   S   R ++    ++++GLK N+P  F V  + A
Sbjct: 715  PIKHTIIISWGGVNVPKSPFRVNVGEGSHPERVKVYGPGVEKTGLKANEPTYFTVDCSEA 774

Query: 1881 -KGAIDAKVH------SPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPG 2039
             +G +   +        P+ A  +  + + D D + V++ P   G Y I V F    IP 
Sbjct: 775  GQGDVSIGIKCAPGVVGPAEADIDFDIIKNDNDTFTVKYTPPGAGRYTIMVLFANQEIPA 834

Query: 2040 SPFKIRVGEPGHGGDPGLVSAYGAGLE--GGVTGSPAEFIVNTSNAGAGALSVTIDGPSK 2213
            SPF I+V +P H  D   V A G GL   G   G P  F V T  AG   L V   G +K
Sbjct: 835  SPFHIKV-DPSH--DASKVKAEGPGLNRTGVEVGKPTHFTVLTKGAGKAKLDVHFAGAAK 891

Query: 2214 VKM-----DCQECPEGYRVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHS 2378
             +              Y V YT +  G+  +++ YGG   +  SPF   V          
Sbjct: 892  GEAVRDFEIIDNHDYSYTVKYTAVQQGNMAVTVTYGGD-PVPKSPFVVNVA--------- 941

Query: 2379 LHETSSVFVDSLTKTXXXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKA- 2555
                                           SKV  +GL  SK  VGQ+ +F+V+   A 
Sbjct: 942  --------------------------PPLDLSKVKVQGLN-SKVAVGQEQAFSVNTRGAG 974

Query: 2556 GNNMLLVGVHGP-RTPCEEILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRV 2732
            G   L V +  P R P    L    G+   +V Y+  ++G Y + + +    +PGSP+ V
Sbjct: 975  GQGQLDVRMTSPSRRPIPCKLEPGGGADAQAVRYMPPEEGPYKVDITYDGHPVPGSPFAV 1034


>ref|XP_003360191.1| PREDICTED: filamin-C [Sus scrofa].
          Length = 2599

 Score = 1354 bits (3505), Expect = 0.0
 Identities = 648/879 (73%), Positives = 763/879 (86%), Gaps = 3/879 (0%)
 Frame = +3

Query: 114  APERPLVGVNGLDVTSLRPFDLVIPFTIKKGEITGEVRMPSGKVAQPAITDNKDGTVTVR 293
            A E P+V V  ++ + LRPF+LVIPFT++KGE+TGEVRMPSGK A+P ITDNKDGT+TVR
Sbjct: 1722 ATEEPVVPVESME-SMLRPFNLVIPFTVQKGELTGEVRMPSGKTARPNITDNKDGTITVR 1780

Query: 294  YAPSEAGLHEMDIRYDNMHIPGSPLQFYVDYVNCGHVTAYGPGLSHGVVNKPAVFTVNTK 473
            YAP+E GLH+M I+YD  HIPGSPLQFYVD +N  HV+AYGPGLSHG+VNKPA FT+ TK
Sbjct: 1781 YAPTEKGLHQMGIKYDGNHIPGSPLQFYVDAINSRHVSAYGPGLSHGMVNKPATFTIVTK 1840

Query: 474  DAGEGGLSLAIEGPSKAEISCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTAR 653
            DAGEGGLSLA+EGPSKAEI+C DN+DGTC+VSYLP  PGDYSI+V+++++HIPGSPFTA+
Sbjct: 1841 DAGEGGLSLAVEGPSKAEITCKDNKDGTCTVSYLPTAPGDYSIIVRFDDKHIPGSPFTAK 1900

Query: 654  VTGDDSMRMSHLKVGSAADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISF 833
            +TGDDSMR S L VG++ D+ + I+E+DLS LTA++  PSG EEPCLLKRL N H+GISF
Sbjct: 1901 ITGDDSMRTSQLNVGTSTDVSLKITESDLSQLTASIRAPSGNEEPCLLKRLPNRHIGISF 1960

Query: 834  VPKETGEHLVHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEGHTFEPAEFIID 1013
             PKE GEH+V V+K+G+HV +SP  +++  SEIGDAS+VRV G+GL EG TF+ AEFI+D
Sbjct: 1961 TPKEVGEHVVSVRKSGKHVTNSPFKILVGPSEIGDASKVRVWGKGLSEGQTFQVAEFIVD 2020

Query: 1014 TRDAGYGGLSLSIEGPSKVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFS 1193
            TR+AGYGGL LSIEGPSKVDIN ED+EDGTC+VTYCPTEPG YIINIKFAD+HVPGSPF+
Sbjct: 2021 TRNAGYGGLGLSIEGPSKVDINCEDMEDGTCKVTYCPTEPGTYIINIKFADKHVPGSPFT 2080

Query: 1194 VKVTGEGRVKESITRRQRAPSVANVGSHCDLSLKIP-EISIQDMTAQVTSPSGKSHEAEI 1370
            VKVTGEGR+KESITRR++APS+A +GS CDL+LKIP E S QDMTAQVTSPSGK+  AEI
Sbjct: 2081 VKVTGEGRMKESITRRRQAPSIATIGSTCDLNLKIPGEASSQDMTAQVTSPSGKTEAAEI 2140

Query: 1371 VEGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLER 1550
            VEGE+  Y +RFVP EMG HTV+VKY+GQHVPGSPFQFTVGPLGEGGAHKVRAGG GLER
Sbjct: 2141 VEGEDSAYSVRFVPQEMGPHTVTVKYRGQHVPGSPFQFTVGPLGEGGAHKVRAGGTGLER 2200

Query: 1551 AEAGVPAEFSIWTREAGAGGLAIAVEGPSKAEISFEDRKDGSCGVAYVVQEPGDYEVSVK 1730
              AGVPAEFSIWTREAGAGGL+IAVEGPSKAEI+FEDRKDGSCGV+YVVQEPGDYEVS+K
Sbjct: 2201 GVAGVPAEFSIWTREAGAGGLSIAVEGPSKAEIAFEDRKDGSCGVSYVVQEPGDYEVSIK 2260

Query: 1731 FNEEHIPDSPFVVPVASPSGDARRLTVSSLQESGLKVNQPASFAVSLNGAKGAIDAKVHS 1910
            FN+EHIPDSPFVVPVAS S DARRLTV+SLQE+GLKVNQPASFAV LNGA+G IDA+VH+
Sbjct: 2261 FNDEHIPDSPFVVPVASLSDDARRLTVTSLQETGLKVNQPASFAVQLNGARGVIDARVHT 2320

Query: 1911 PSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPG 2090
            PSGA+EECYV+E+D DK+ +RFIP ENGV+ IDVKFNG HIPGSPFKIRVGE    GDPG
Sbjct: 2321 PSGAVEECYVSELDSDKHTIRFIPHENGVHSIDVKFNGAHIPGSPFKIRVGEQSQAGDPG 2380

Query: 2091 LVSAYGAGLEGGVTGSPAEFIVNTSNAGAGALSVTIDGPSKVKMDCQECPEGYRVTYTPM 2270
            LVSAYG GLEGG TG  +EFIVNT NAG+GALSVTIDGPSKV++DC+ECPEG+ VTYTPM
Sbjct: 2381 LVSAYGPGLEGGTTGVSSEFIVNTLNAGSGALSVTIDGPSKVQLDCRECPEGHVVTYTPM 2440

Query: 2271 APGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSVFVDSLTK--TXXXXXXX 2444
            APG+YLI+IKYGGP HI GSPFKA+VTG RL   HSLHETS+V V+++TK  +       
Sbjct: 2441 APGNYLIAIKYGGPQHIVGSPFKAKVTGPRLSGGHSLHETSTVLVETVTKSSSSRGSSYS 2500

Query: 2445 XXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKAGNNMLLVGVHGPRTPCEEILVKH 2624
                     SKV+ +G GLS+A+VGQK SFTVDCSKAG NM++VGVHGP+TPCEE+ VKH
Sbjct: 2501 SIPKFSSDASKVVTRGPGLSQAFVGQKNSFTVDCSKAGTNMMMVGVHGPKTPCEEVYVKH 2560

Query: 2625 VGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLVP 2741
            VG+R+Y+V+Y +K+KG+Y L+VKWGDE +PGSP++V VP
Sbjct: 2561 VGNRVYNVTYTVKEKGDYILIVKWGDESVPGSPFKVNVP 2599



 Score =  481 bits (1238), Expect = e-135
 Identities = 308/883 (34%), Positives = 453/883 (51%), Gaps = 18/883 (2%)
 Frame = +3

Query: 144  GLDVTSLRPFDLVIPFTIK-----KGEITGEVRMPSGKVAQPAITDNKDGTVTVRYAPSE 308
            GL+ + + P  L + FTI      +G +T ++  P GK  +  I DN DGT TV Y P  
Sbjct: 1544 GLNASGI-PASLPVEFTIDARDAGEGLLTVQILDPEGKPKKANIRDNGDGTYTVSYLPDM 1602

Query: 309  AGLHEMDIRYDNMHIPGSPLQFYV----DYVNCGHVTA-YGPGLSHGVVNKPAVFTVNTK 473
            +G + + I+Y    IP SP + +     D   C    A  GP +    + +  V TV+ K
Sbjct: 1603 SGRYTITIKYGGDEIPYSPFRIHALPTGDASKCLVTGACLGPRIQ---IGEETVITVDAK 1659

Query: 474  DAGEGGLSLAIEGPSKAE--ISCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFT 647
             AG+G ++  +  P  AE  +   +N DGT  + Y    PG Y I +++  +HIP SPF 
Sbjct: 1660 AAGKGKVTCTVSTPDGAELDVDVVENHDGTFDIYYTAPEPGKYVITIRFGGEHIPNSPFH 1719

Query: 648  ARVTGDDSM---RMSHLKVGSAADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGH 818
               T +  +    M  +       IP  + + +   LT  V  PSG+     +   ++G 
Sbjct: 1720 VLATEEPVVPVESMESMLRPFNLVIPFTVQKGE---LTGEVRMPSGKTARPNITDNKDGT 1776

Query: 819  VGISFVPKETGEHLVHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEGHTFEPA 998
            + + + P E G H + +K +G H+  SP+   +   +  ++  V   G GL  G   +PA
Sbjct: 1777 ITVRYAPTEKGLHQMGIKYDGNHIPGSPLQFYV---DAINSRHVSAYGPGLSHGMVNKPA 1833

Query: 999  EFIIDTRDAGYGGLSLSIEGPSKVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVP 1178
             F I T+DAG GGLSL++EGPSK +I  +D +DGTC V+Y PT PG+Y I ++F D+H+P
Sbjct: 1834 TFTIVTKDAGEGGLSLAVEGPSKAEITCKDNKDGTCTVSYLPTAPGDYSIIVRFDDKHIP 1893

Query: 1179 GSPFSVKVTGEGRVKESITRRQRAPSVANVGSHCDLSLKIPEISIQDMTAQVTSPSGKSH 1358
            GSPF+ K+TG+  ++          S  NVG+  D+SLKI E  +  +TA + +PSG   
Sbjct: 1894 GSPFTAKITGDDSMR---------TSQLNVGTSTDVSLKITESDLSQLTASIRAPSGNEE 1944

Query: 1359 EAEIVEGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGP 1538
               +    N    I F P E+G H VSV+  G+HV  SPF+  VGP   G A KVR  G 
Sbjct: 1945 PCLLKRLPNRHIGISFTPKEVGEHVVSVRKSGKHVTNSPFKILVGPSEIGDASKVRVWGK 2004

Query: 1539 GLERAEAGVPAEFSIWTREAGAGGLAIAVEGPSKAEISFEDRKDGSCGVAYVVQEPGDYE 1718
            GL   +    AEF + TR AG GGL +++EGPSK +I+ ED +DG+C V Y   EPG Y 
Sbjct: 2005 GLSEGQTFQVAEFIVDTRNAGYGGLGLSIEGPSKVDINCEDMEDGTCKVTYCPTEPGTYI 2064

Query: 1719 VSVKFNEEHIPDSPFVVPVASPSGDARRLTVSSLQESGLKVNQPASFAVSLNGAKGAID- 1895
            +++KF ++H+P SPF V V         +T      S   +       + + G   + D 
Sbjct: 2065 INIKFADKHVPGSPFTVKVTGEGRMKESITRRRQAPSIATIGSTCDLNLKIPGEASSQDM 2124

Query: 1896 -AKVHSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPG 2072
             A+V SPSG  E   + E +   Y+VRF+P+E G + + VK+ G H+PGSPF+  VG  G
Sbjct: 2125 TAQVTSPSGKTEAAEIVEGEDSAYSVRFVPQEMGPHTVTVKYRGQHVPGSPFQFTVGPLG 2184

Query: 2073 HGGDPGLVSAYGAGLEGGVTGSPAEFIVNTSNAGAGALSVTIDGPSKVKMDCQECPEG-Y 2249
             GG    V A G GLE GV G PAEF + T  AGAG LS+ ++GPSK ++  ++  +G  
Sbjct: 2185 EGG-AHKVRAGGTGLERGVAGVPAEFSIWTREAGAGGLSIAVEGPSKAEIAFEDRKDGSC 2243

Query: 2250 RVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSVFVDSLTKTXX 2429
             V+Y    PG Y +SIK+    HI  SPF   V     +S+ +   T    V SL +T  
Sbjct: 2244 GVSYVVQEPGDYEVSIKFNDE-HIPDSPFVVPVAS---LSDDARRLT----VTSLQET-- 2293

Query: 2430 XXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKAGNNMLLVGVHGPRTPCEE 2609
                                  GL    V Q  SF V  + A   ++   VH P    EE
Sbjct: 2294 ----------------------GLK---VNQPASFAVQLNGA-RGVIDARVHTPSGAVEE 2327

Query: 2610 ILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLV 2738
              V  + S  +++ ++  + G +++ VK+   HIPGSP+++ V
Sbjct: 2328 CYVSELDSDKHTIRFIPHENGVHSIDVKFNGAHIPGSPFKIRV 2370



 Score =  358 bits (919), Expect = 1e-98
 Identities = 278/885 (31%), Positives = 414/885 (46%), Gaps = 40/885 (4%)
 Frame = +3

Query: 204  GEITGEVRMPSGK--VAQPAITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFY 377
            G++   +  P G+    + A+ D  D T    Y P   G H + + +    I  SP   +
Sbjct: 388  GDVAVVIVDPQGRRDTVEVALEDKGDSTFRCTYRPVMEGPHTVHVAFAGAPITRSPFPVH 447

Query: 378  V-DYVNCGHVTAYGPGLS-HGV-VNKPAVFTVNTKDAGEGGLSLAIEGPSKAE--ISCTD 542
            V +  N     A G GL   GV V + A F V TK AG G L + ++GP   E  +   D
Sbjct: 448  VAEACNPNACRASGRGLQPKGVRVKEVADFKVFTKGAGSGELKVTVKGPKGTEEPVKVRD 507

Query: 543  NQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARVTGDDSMR--------MSHLKVG 698
              DG     Y PV+PG Y + + +    IP SPF  +V+ +  M+        +   +VG
Sbjct: 508  AGDGVFECEYYPVVPGKYVVTITWGGYAIPRSPFEVQVSPEAGMQKVRAWGPGLETGQVG 567

Query: 699  SAADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKN 878
             +AD  +    T++  L  ++  PS  +  C  K   +G   + + P E GE+ VHV  +
Sbjct: 568  KSADFVVEAIGTEVGTLGFSIEGPSQAKIECDDK--GDGSCDVRYWPTEPGEYAVHVICD 625

Query: 879  GQHVASSPIPVVISQSEIG-DASRVRVSGRGLHEGHTF--EPAEFIIDTRDAGYGGLSLS 1049
             + +  SP    I  +       +V+  G GL        +PAEF ID R AG G L L 
Sbjct: 626  DEDIRDSPFIAHIQPAPPDCFPDKVKAFGPGLEPTGCIVDKPAEFTIDARAAGKGDLKLY 685

Query: 1050 IEGPS--KVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTGEGRVK 1223
             +      +DI      DGT R +Y PT+P  + I I +   +VP SPF V V GEG   
Sbjct: 686  AQDADGCPIDIKVIPNGDGTFRCSYVPTKPIKHTIIISWGGVNVPKSPFRVNV-GEGSHP 744

Query: 1224 ESITRRQRAPSVANVGSHCD----LSLKIPEISIQDMT------AQVTSPSGKSHEAEIV 1373
            E +  +   P V   G   +     ++   E    D++        V  P+    + +I+
Sbjct: 745  ERV--KVYGPGVEKTGLKANEPTYFTVDCSEAGQGDVSIGIKCAPGVVGPAEADIDFDII 802

Query: 1374 EGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLER- 1550
            + +N T+ +++ P   G +T+ V +  Q +P SPF   V P  +  A KV+A GPGL R 
Sbjct: 803  KNDNDTFTVKYTPPGAGRYTIMVLFANQEIPASPFHIKVDPSHD--ASKVKAEGPGLNRT 860

Query: 1551 -AEAGVPAEFSIWTREAGAGGLAIAVEGPSKAEI--SFE--DRKDGSCGVAYVVQEPGDY 1715
              E G P  F++ T+ AG   L +   G +K E    FE  D  D S  V Y   + G+ 
Sbjct: 861  GVEVGKPTHFTVLTKGAGKAKLDVHFAGAAKGEAVRDFEIIDNHDYSYTVKYTAVQQGNM 920

Query: 1716 EVSVKFNEEHIPDSPFVVPVASPSGDARRLTVSSLQESGLKVNQPASFAVSLNGA--KGA 1889
             V+V +  + +P SPFVV VA P  D  ++ V  L  S + V Q  +F+V+  GA  +G 
Sbjct: 921  AVTVTYGGDPVPKSPFVVNVAPPL-DLSKVKVQGL-NSKVAVGQEQAFSVNTRGAGGQGQ 978

Query: 1890 IDAKVHSPSGALEECYVTE-IDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGE 2066
            +D ++ SPS     C +      D  AVR++P E G Y +D+ ++G  +PGSPF +    
Sbjct: 979  LDVRMTSPSRRPIPCKLEPGGGADAQAVRYMPPEEGPYKVDITYDGHPVPGSPFAVEGVL 1038

Query: 2067 PGHGGDPGLVSAYGAGLEGGVTGSPAEFIVNTSNAGAGALSVTIDGPSKVKMDCQECPEG 2246
            P    DP  V AYG GL+GG+ G+PA F ++T  AG G L +T++GP + K++CQ+  +G
Sbjct: 1039 P---PDPSKVCAYGPGLKGGLVGTPAPFSIDTKGAGTGGLGLTVEGPCEAKIECQDNGDG 1095

Query: 2247 -YRVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSVFVDSLTKT 2423
               V+Y P  PG Y I+I +    HI GSPFKA +                VF       
Sbjct: 1096 SCAVSYLPTEPGEYTINILF-AEAHIPGSPFKATI--------------RPVF------- 1133

Query: 2424 XXXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKAGNNMLLVGVHGPRTPC 2603
                            SKV A G GL +   G+  +FTVDCS+AG   L + +       
Sbjct: 1134 --------------DPSKVRASGPGLERGKAGEAATFTVDCSEAGEAELTIEILSDAGVK 1179

Query: 2604 EEILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLV 2738
             E+L+ +     Y ++Y     G YT+ +K+G   +P  P RV V
Sbjct: 1180 AEVLIHNNADGTYHITYSPAFPGTYTITIKYGGHPVPKFPTRVHV 1224



 Score =  320 bits (819), Expect = 4e-87
 Identities = 247/897 (27%), Positives = 400/897 (44%), Gaps = 51/897 (5%)
 Frame = +3

Query: 201  KGEITGEVRMPSGKVAQPAITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFYV 380
            + E+T E+   +G  A+  I +N DGT  + Y+P+  G + + I+Y    +P  P + +V
Sbjct: 1165 EAELTIEILSDAGVKAEVLIHNNADGTYHITYSPAFPGTYTITIKYGGHPVPKFPTRVHV 1224

Query: 381  D-YVNCGHVTAYGPGLS-HGVVNKPAV-FTVNTKD---AGEGGLSLAIEGPS--KAEISC 536
               V+   V   GPG+  HGV+ +    FTV+ +     G   ++  +  PS  K +   
Sbjct: 1225 QPAVDTSGVKVSGPGVEPHGVLREVTTEFTVDARSLTATGGNHVTARVLNPSGAKTDTYV 1284

Query: 537  TDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARVT-GDDSMRMSHL-------K 692
            TDN DGT  V Y     G + + V Y++  +P SPF   VT G D  R+           
Sbjct: 1285 TDNGDGTYRVQYTAYEEGVHLVEVLYDDVAVPKSPFRVGVTEGCDPTRVRAFGPGLEGGL 1344

Query: 693  VGSAADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVK 872
            V  A    +         L   +  PS  +  C  K  ++G   + ++P   G++ V++ 
Sbjct: 1345 VNKANRFTVETRGAGTGGLGLAIEGPSEAKMSC--KDNKDGSCTVEYIPFTPGDYDVNIT 1402

Query: 873  KNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEG-HTFEPAEFIIDTRDAGYGGLSLS 1049
              G+ +  SP  V +   ++ D  +V+ SG GL  G     P  F +D   AG   L ++
Sbjct: 1403 FGGRPIPGSPFRVPV--KDVVDPGKVKCSGPGLGAGVRARVPQTFTVDCSQAGRAPLQVA 1460

Query: 1050 IEGPSKVD------------------INTEDLEDGTCRVTYCPTEPGNYIINIKFADQHV 1175
            +  P+ +D                  +   D  DGT  V Y P   G Y + +K+ADQ V
Sbjct: 1461 VLSPTGMDCLGQGGGRRDRVPGVAEPVEVRDNGDGTHTVHYTPATDGPYTVAVKYADQEV 1520

Query: 1176 PGSPFSVKVTGEGRVKESITRRQRAPSVANVGSHCDLSLKIPEISIQD-----MTAQVTS 1340
            P SPF +KV       ++   R   P +   G    L ++   I  +D     +T Q+  
Sbjct: 1521 PRSPFKIKVL---PAHDASKVRASGPGLNASGIPASLPVEF-TIDARDAGEGLLTVQILD 1576

Query: 1341 PSGKSHEAEIVEGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHK 1520
            P GK  +A I +  + TY + ++P   G +T+++KY G  +P SPF+    P G+     
Sbjct: 1577 PEGKPKKANIRDNGDGTYTVSYLPDMSGRYTITIKYGGDEIPYSPFRIHALPTGDASKCL 1636

Query: 1521 VRAGGPGLERAEAGVPAEFSIWTREAGAGGLAIAVEGPSKAEISFE--DRKDGSCGVAYV 1694
            V     G  R + G     ++  + AG G +   V  P  AE+  +  +  DG+  + Y 
Sbjct: 1637 VTGACLG-PRIQIGEETVITVDAKAAGKGKVTCTVSTPDGAELDVDVVENHDGTFDIYYT 1695

Query: 1695 VQEPGDYEVSVKFNEEHIPDSPF--------VVPVASPSGDARRLTVSSLQESGLKVNQP 1850
              EPG Y ++++F  EHIP+SPF        VVPV S              ES L+   P
Sbjct: 1696 APEPGKYVITIRFGGEHIPNSPFHVLATEEPVVPVES-------------MESMLR---P 1739

Query: 1851 ASFAVSLNGAKGAIDAKVHSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTH 2030
             +  +     KG +  +V  PSG      +T+       VR+ P E G++ + +K++G H
Sbjct: 1740 FNLVIPFTVQKGELTGEVRMPSGKTARPNITDNKDGTITVRYAPTEKGLHQMGIKYDGNH 1799

Query: 2031 IPGSPFKIRVGEPGHGGDPGLVSAYGAGLEGGVTGSPAEFIVNTSNAGAGALSVTIDGPS 2210
            IPGSP +  V       +   VSAYG GL  G+   PA F + T +AG G LS+ ++GPS
Sbjct: 1800 IPGSPLQFYV----DAINSRHVSAYGPGLSHGMVNKPATFTIVTKDAGEGGLSLAVEGPS 1855

Query: 2211 KVKMDCQECPEG-YRVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHE 2387
            K ++ C++  +G   V+Y P APG Y I +++    HI GSPF A++TG           
Sbjct: 1856 KAEITCKDNKDGTCTVSYLPTAPGDYSIIVRFDDK-HIPGSPFTAKITG----------- 1903

Query: 2388 TSSVFVDSLTKTXXXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKAGNNM 2567
                  D   +T                          S+  VG     ++  +++  + 
Sbjct: 1904 ------DDSMRT--------------------------SQLNVGTSTDVSLKITESDLSQ 1931

Query: 2568 LLVGVHGPRTPCEEILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLV 2738
            L   +  P    E  L+K + +R   +S+  K+ GE+ + V+   +H+  SP+++LV
Sbjct: 1932 LTASIRAPSGNEEPCLLKRLPNRHIGISFTPKEVGEHVVSVRKSGKHVTNSPFKILV 1988



 Score =  298 bits (763), Expect = 1e-80
 Identities = 247/895 (27%), Positives = 384/895 (42%), Gaps = 50/895 (5%)
 Frame = +3

Query: 204  GEITGEVRMPSGKVAQPAITDN--KDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFY 377
            GE+   +  P G   +  +  N  KD T  V Y P  AGLH++ + +   +I  SP +  
Sbjct: 288  GEVLVYIEDPEGHTEEAKVVPNNDKDRTYAVSYVPKVAGLHKVTVLFAGQNIERSPFEVN 347

Query: 378  VDYV--NCGHVTAYGPGLS--HGVVNKPAVFTVNTKDAGEGGLSLAIEGP----SKAEIS 533
            V     +   V+A GPGL     V NKP  F + T  AG G +++ I  P       E++
Sbjct: 348  VGMALGDANKVSARGPGLEPVGNVANKPTYFDIYTAGAGTGDVAVVIVDPQGRRDTVEVA 407

Query: 534  CTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARV----------TGDDSMRMS 683
              D  D T   +Y PV+ G +++ V +    I  SPF   V               ++  
Sbjct: 408  LEDKGDSTFRCTYRPVMEGPHTVHVAFAGAPITRSPFPVHVAEACNPNACRASGRGLQPK 467

Query: 684  HLKVGSAADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLV 863
             ++V   AD  +         L  TV  P G EEP  ++   +G     + P   G+++V
Sbjct: 468  GVRVKEVADFKVFTKGAGSGELKVTVKGPKGTEEPVKVRDAGDGVFECEYYPVVPGKYVV 527

Query: 864  HVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEGHTFEPAEFIIDTRDAGYGGLS 1043
             +   G  +  SP  V +S        +VR  G GL  G   + A+F+++      G L 
Sbjct: 528  TITWGGYAIPRSPFEVQVSPE--AGMQKVRAWGPGLETGQVGKSADFVVEAIGTEVGTLG 585

Query: 1044 LSIEGPSKVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTGEGRVK 1223
             SIEGPS+  I  +D  DG+C V Y PTEPG Y +++   D+ +  SPF   +  +    
Sbjct: 586  FSIEGPSQAKIECDDKGDGSCDVRYWPTEPGEYAVHVICDDEDIRDSPFIAHI--QPAPP 643

Query: 1224 ESITRRQRA------PSVANVGSHCDLSLKIPEISIQDMTAQVTSPSGKSHEAEIVEGEN 1385
            +    + +A      P+   V    + ++        D+        G   + +++   +
Sbjct: 644  DCFPDKVKAFGPGLEPTGCIVDKPAEFTIDARAAGKGDLKLYAQDADGCPIDIKVIPNGD 703

Query: 1386 HTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAH--KVRAGGPGLERA-- 1553
             T+   +VP +   HT+ + + G +VP SPF+  VG     G+H  +V+  GPG+E+   
Sbjct: 704  GTFRCSYVPTKPIKHTIIISWGGVNVPKSPFRVNVGE----GSHPERVKVYGPGVEKTGL 759

Query: 1554 EAGVPAEFSIWTREAGAGGLAIAVE------GPSKAEISFEDRK--DGSCGVAYVVQEPG 1709
            +A  P  F++   EAG G ++I ++      GP++A+I F+  K  + +  V Y     G
Sbjct: 760  KANEPTYFTVDCSEAGQGDVSIGIKCAPGVVGPAEADIDFDIIKNDNDTFTVKYTPPGAG 819

Query: 1710 DYEVSVKFNEEHIPDSPFVVPVASPSGDARRLTVS--SLQESGLKVNQPASFAVSLNGAK 1883
             Y + V F  + IP SPF + V  PS DA ++      L  +G++V +P  F V   GA 
Sbjct: 820  RYTIMVLFANQEIPASPFHIKV-DPSHDASKVKAEGPGLNRTGVEVGKPTHFTVLTKGA- 877

Query: 1884 GAIDAKVH----SPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFK 2051
            G     VH    +   A+ +  + +     Y V++   + G   + V + G  +P SPF 
Sbjct: 878  GKAKLDVHFAGAAKGEAVRDFEIIDNHDYSYTVKYTAVQQGNMAVTVTYGGDPVPKSPFV 937

Query: 2052 IRVGEPGHGGDPGLVSAYGAGLEGGVTGSPAEFIVNTSNAGA-GALSVTIDGPSKVKMDC 2228
            + V  P    D   V   G   +  V G    F VNT  AG  G L V +  PS+  + C
Sbjct: 938  VNVAPP---LDLSKVKVQGLNSKVAV-GQEQAFSVNTRGAGGQGQLDVRMTSPSRRPIPC 993

Query: 2229 QECPEG----YRVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSS 2396
            +  P G      V Y P   G Y + I Y G + + GSPF                    
Sbjct: 994  KLEPGGGADAQAVRYMPPEEGPYKVDITYDG-HPVPGSPFAVE----------------- 1035

Query: 2397 VFVDSLTKTXXXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKAGNNMLLV 2576
                                     SKV A G GL    VG    F++D   AG   L +
Sbjct: 1036 ------------------GVLPPDPSKVCAYGPGLKGGLVGTPAPFSIDTKGAGTGGLGL 1077

Query: 2577 GVHGPRTPCE-EILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLV 2738
             V G   PCE +I  +  G    +VSYL  + GEYT+ + + + HIPGSP++  +
Sbjct: 1078 TVEG---PCEAKIECQDNGDGSCAVSYLPTEPGEYTINILFAEAHIPGSPFKATI 1129



 Score =  298 bits (762), Expect = 2e-80
 Identities = 269/910 (29%), Positives = 408/910 (44%), Gaps = 64/910 (7%)
 Frame = +3

Query: 201  KGEITGEVRMPSGKVAQPAITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFYV 380
            KG++    +   G      +  N DGT    Y P++   H + I +  +++P SP +  V
Sbjct: 679  KGDLKLYAQDADGCPIDIKVIPNGDGTFRCSYVPTKPIKHTIIISWGGVNVPKSPFRVNV 738

Query: 381  -DYVNCGHVTAYGPGLSHG--VVNKPAVFTVNTKDAGEGGLSLAIE------GPSKAEI- 530
             +  +   V  YGPG+       N+P  FTV+  +AG+G +S+ I+      GP++A+I 
Sbjct: 739  GEGSHPERVKVYGPGVEKTGLKANEPTYFTVDCSEAGQGDVSIGIKCAPGVVGPAEADID 798

Query: 531  -SCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARVTGDDSMRMSHLKVGSAA 707
                 N + T +V Y P   G Y+I+V +  Q IP SPF  +V  D S   S +K   A 
Sbjct: 799  FDIIKNDNDTFTVKYTPPGAGRYTIMVLFANQEIPASPFHIKV--DPSHDASKVK---AE 853

Query: 708  DIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVG-----------------ISFV 836
               +N +  ++   T   V   G  +  L         G                 + + 
Sbjct: 854  GPGLNRTGVEVGKPTHFTVLTKGAGKAKLDVHFAGAAKGEAVRDFEIIDNHDYSYTVKYT 913

Query: 837  PKETGEHLVHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEGHTFEPAEFIIDT 1016
              + G   V V   G  V  SP   V++ +   D S+V+V G         E A F ++T
Sbjct: 914  AVQQGNMAVTVTYGGDPVPKSPF--VVNVAPPLDLSKVKVQGLNSKVAVGQEQA-FSVNT 970

Query: 1017 RDA-GYGGLSLSIEGPSKVDINTEDLEDG----TCRVTYCPTEPGNYIINIKFADQHVPG 1181
            R A G G L + +  PS+  I  + LE G       V Y P E G Y ++I +    VPG
Sbjct: 971  RGAGGQGQLDVRMTSPSRRPIPCK-LEPGGGADAQAVRYMPPEEGPYKVDITYDGHPVPG 1029

Query: 1182 SPFSVKVTGEGRVKESITR-RQRAPSVAN--VGSHCDLSLKIPEISIQDMTAQVTSPSGK 1352
            SPF+V    EG +    ++     P +    VG+    S+         +   V  P   
Sbjct: 1030 SPFAV----EGVLPPDPSKVCAYGPGLKGGLVGTPAPFSIDTKGAGTGGLGLTVEGPCEA 1085

Query: 1353 SHEAEIVEGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAG 1532
              E +  +  + +  + ++P E G +T+++ +   H+PGSPF+ T+ P+ +    KVRA 
Sbjct: 1086 KIECQ--DNGDGSCAVSYLPTEPGEYTINILFAEAHIPGSPFKATIRPVFD--PSKVRAS 1141

Query: 1533 GPGLERAEAGVPAEFSIWTREAGAGGLAIAV--EGPSKAEISFEDRKDGSCGVAYVVQEP 1706
            GPGLER +AG  A F++   EAG   L I +  +   KAE+   +  DG+  + Y    P
Sbjct: 1142 GPGLERGKAGEAATFTVDCSEAGEAELTIEILSDAGVKAEVLIHNNADGTYHITYSPAFP 1201

Query: 1707 GDYEVSVKFNEEHIPDSPFVVPVASPSGDARRLTVS--SLQESGLKVNQPASFAV---SL 1871
            G Y +++K+    +P  P  V V  P+ D   + VS   ++  G+       F V   SL
Sbjct: 1202 GTYTITIKYGGHPVPKFPTRVHV-QPAVDTSGVKVSGPGVEPHGVLREVTTEFTVDARSL 1260

Query: 1872 NGAKG-AIDAKVHSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPF 2048
                G  + A+V +PSGA  + YVT+     Y V++   E GV+L++V ++   +P SPF
Sbjct: 1261 TATGGNHVTARVLNPSGAKTDTYVTDNGDGTYRVQYTAYEEGVHLVEVLYDDVAVPKSPF 1320

Query: 2049 KIRVGEPGHGGDPGLVSAYGAGLEGGVTGSPAEFIVNTSNAGAGALSVTIDGPSKVKMDC 2228
            ++ V E   G DP  V A+G GLEGG+      F V T  AG G L + I+GPS+ KM C
Sbjct: 1321 RVGVTE---GCDPTRVRAFGPGLEGGLVNKANRFTVETRGAGTGGLGLAIEGPSEAKMSC 1377

Query: 2229 QECPEG-YRVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSVFV 2405
            ++  +G   V Y P  PG Y ++I +GG   I GSPF+  V                  V
Sbjct: 1378 KDNKDGSCTVEYIPFTPGDYDVNITFGG-RPIPGSPFRVPVKD---------------VV 1421

Query: 2406 DSLTKTXXXXXXXXXXXXXXXXSKVLAKGLGLS---KAYVGQKGSFTVDCSKAGNNMLLV 2576
            D                      KV   G GL    +A V Q  +FTVDCS+AG   L V
Sbjct: 1422 D--------------------PGKVKCSGPGLGAGVRARVPQ--TFTVDCSQAGRAPLQV 1459

Query: 2577 GVHGP--------------RTP--CEEILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEH 2708
             V  P              R P   E + V+  G   ++V Y     G YT+ VK+ D+ 
Sbjct: 1460 AVLSPTGMDCLGQGGGRRDRVPGVAEPVEVRDNGDGTHTVHYTPATDGPYTVAVKYADQE 1519

Query: 2709 IPGSPYRVLV 2738
            +P SP+++ V
Sbjct: 1520 VPRSPFKIKV 1529



 Score =  274 bits (700), Expect = 2e-73
 Identities = 243/873 (27%), Positives = 374/873 (42%), Gaps = 40/873 (4%)
 Frame = +3

Query: 264  DNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFYVDYV--NC--GHVTAYGPGLSH 431
            D  DG+  VRY P+E G + + +  D+  I  SP   ++     +C    V A+GPGL  
Sbjct: 600  DKGDGSCDVRYWPTEPGEYAVHVICDDEDIRDSPFIAHIQPAPPDCFPDKVKAFGPGLEP 659

Query: 432  G--VVNKPAVFTVNTKDAGEGGLSLAIEGPSKA--EISCTDNQDGTCSVSYLPVLPGDYS 599
               +V+KPA FT++ + AG+G L L  +       +I    N DGT   SY+P  P  ++
Sbjct: 660  TGCIVDKPAEFTIDARAAGKGDLKLYAQDADGCPIDIKVIPNGDGTFRCSYVPTKPIKHT 719

Query: 600  ILVKYNEQHIPGSPFTARVTGDDS-----------MRMSHLKVGSAADIPINISET---D 737
            I++ +   ++P SPF   V G+ S           +  + LK        ++ SE    D
Sbjct: 720  IIISWGGVNVPKSPFRVNV-GEGSHPERVKVYGPGVEKTGLKANEPTYFTVDCSEAGQGD 778

Query: 738  LSL---LTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNGQHVASSPIP 908
            +S+       VV P+  +    + +  N    + + P   G + + V    Q + +SP  
Sbjct: 779  VSIGIKCAPGVVGPAEADIDFDIIKNDNDTFTVKYTPPGAGRYTIMVLFANQEIPASPFH 838

Query: 909  VVISQSEIGDASRVRVSGRGLHEG--HTFEPAEFIIDTRDAGYGGLSLSIEGPSKV---- 1070
            + +  S   DAS+V+  G GL+       +P  F + T+ AG   L +   G +K     
Sbjct: 839  IKVDPSH--DASKVKAEGPGLNRTGVEVGKPTHFTVLTKGAGKAKLDVHFAGAAKGEAVR 896

Query: 1071 DINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTGEGRVKESITRRQRA 1250
            D    D  D +  V Y   + GN  + + +    VP SPF V V     +  S  + Q  
Sbjct: 897  DFEIIDNHDYSYTVKYTAVQQGNMAVTVTYGGDPVPKSPFVVNVAPP--LDLSKVKVQGL 954

Query: 1251 PSVANVGSHCDLSLKIPEISIQ-DMTAQVTSPSGKSHEAEIVEGEN-HTYCIRFVPAEMG 1424
             S   VG     S+       Q  +  ++TSPS +    ++  G       +R++P E G
Sbjct: 955  NSKVAVGQEQAFSVNTRGAGGQGQLDVRMTSPSRRPIPCKLEPGGGADAQAVRYMPPEEG 1014

Query: 1425 MHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLERAEAGVPAEFSIWTREAGA 1604
             + V + Y G  VPGSPF   V  +      KV A GPGL+    G PA FSI T+ AG 
Sbjct: 1015 PYKVDITYDGHPVPGSPF--AVEGVLPPDPSKVCAYGPGLKGGLVGTPAPFSIDTKGAGT 1072

Query: 1605 GGLAIAVEGPSKAEISFEDRKDGSCGVAYVVQEPGDYEVSVKFNEEHIPDSPFVVPVASP 1784
            GGL + VEGP +A+I  +D  DGSC V+Y+  EPG+Y +++ F E HIP SPF   +  P
Sbjct: 1073 GGLGLTVEGPCEAKIECQDNGDGSCAVSYLPTEPGEYTINILFAEAHIPGSPFKATI-RP 1131

Query: 1785 SGDARRLTVSSLQESGLKVNQPASFAVSLNGA-KGAIDAKVHSPSGALEECYVTEIDQDK 1961
              D  ++  S       K  + A+F V  + A +  +  ++ S +G   E  +       
Sbjct: 1132 VFDPSKVRASGPGLERGKAGEAATFTVDCSEAGEAELTIEILSDAGVKAEVLIHNNADGT 1191

Query: 1962 YAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPGLVSAYGAGLEGGVTGSP 2141
            Y + + P   G Y I +K+ G  +P  P ++ V +P        VS  G    G +    
Sbjct: 1192 YHITYSPAFPGTYTITIKYGGHPVPKFPTRVHV-QPAVDTSGVKVSGPGVEPHGVLREVT 1250

Query: 2142 AEFIVNTSN---AGAGALSVTIDGPSKVKMDCQECPEG---YRVTYTPMAPGSYLISIKY 2303
             EF V+  +    G   ++  +  PS  K D      G   YRV YT    G +L+ + Y
Sbjct: 1251 TEFTVDARSLTATGGNHVTARVLNPSGAKTDTYVTDNGDGTYRVQYTAYEEGVHLVEVLY 1310

Query: 2304 GGPYHIGGSPFKARVTGHRLVSNHSLHETSSVFVDSLTKTXXXXXXXXXXXXXXXXSKVL 2483
                 +  SPF+  VT                                        ++V 
Sbjct: 1311 -DDVAVPKSPFRVGVT-----------------------------------EGCDPTRVR 1334

Query: 2484 AKGLGLSKAYVGQKGSFTVDCSKAGNNMLLVGVHGPRTPCEEILVKHVGSRLYSVSYLLK 2663
            A G GL    V +   FTV+   AG   L + + GP            GS   +V Y+  
Sbjct: 1335 AFGPGLEGGLVNKANRFTVETRGAGTGGLGLAIEGPSEAKMSCKDNKDGS--CTVEYIPF 1392

Query: 2664 DKGEYTLVVKWGDEHIPGSPYRVLVP*ALCPGQ 2762
              G+Y + + +G   IPGSP+RV V   + PG+
Sbjct: 1393 TPGDYDVNITFGGRPIPGSPFRVPVKDVVDPGK 1425



 Score =  236 bits (602), Expect = 6e-62
 Identities = 237/840 (28%), Positives = 367/840 (43%), Gaps = 47/840 (5%)
 Frame = +3

Query: 354  PGSPLQFYVDYVNCGHVTAYGPGLSH--GVVNKPAVFTVNTKDAGEGGLSLAIEGP---- 515
            PG+P++     +N     AYGPG+      V +PA FTV T DAG G + + IE P    
Sbjct: 244  PGAPVRS--KQLNPKKAIAYGPGIEPQGNTVLQPAHFTVQTVDAGVGEVLVYIEDPEGHT 301

Query: 516  SKAEISCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARV---TGDD---SMR 677
             +A++   +++D T +VSY+P + G + + V +  Q+I  SPF   V    GD    S R
Sbjct: 302  EEAKVVPNNDKDRTYAVSYVPKVAGLHKVTVLFAGQNIERSPFEVNVGMALGDANKVSAR 361

Query: 678  MSHLK-VGSAADIP----INISETDLSLLTATVVPPSGREE--PCLLKRLRNGHVGISFV 836
               L+ VG+ A+ P    I  +      +   +V P GR +     L+   +     ++ 
Sbjct: 362  GPGLEPVGNVANKPTYFDIYTAGAGTGDVAVVIVDPQGRRDTVEVALEDKGDSTFRCTYR 421

Query: 837  PKETGEHLVHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEG--HTFEPAEFII 1010
            P   G H VHV   G  +  SP PV +  +E  + +  R SGRGL        E A+F +
Sbjct: 422  PVMEGPHTVHVAFAGAPITRSPFPVHV--AEACNPNACRASGRGLQPKGVRVKEVADFKV 479

Query: 1011 DTRDAGYGGLSLSIEGPSKVD--INTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGS 1184
             T+ AG G L ++++GP   +  +   D  DG     Y P  PG Y++ I +    +P S
Sbjct: 480  FTKGAGSGELKVTVKGPKGTEEPVKVRDAGDGVFECEYYPVVPGKYVVTITWGGYAIPRS 539

Query: 1185 PFSVKVTGEGRVKESITRRQRAPSV--ANVGSHCDLSLKIPEISIQDMTAQVTSPSGKSH 1358
            PF V+V+ E  +++    R   P +    VG   D  ++     +  +   +  PS    
Sbjct: 540  PFEVQVSPEAGMQKV---RAWGPGLETGQVGKSADFVVEAIGTEVGTLGFSIEGPSQAKI 596

Query: 1359 EAEIVEGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPL-GEGGAHKVRAGG 1535
            E +  +  + +  +R+ P E G + V V    + +  SPF   + P   +    KV+A G
Sbjct: 597  ECD--DKGDGSCDVRYWPTEPGEYAVHVICDDEDIRDSPFIAHIQPAPPDCFPDKVKAFG 654

Query: 1536 PGLERAEAGV--PAEFSIWTREAGAGGLAIAVEGPSKAEISFE--DRKDGSCGVAYVVQE 1703
            PGLE     V  PAEF+I  R AG G L +  +      I  +     DG+   +YV  +
Sbjct: 655  PGLEPTGCIVDKPAEFTIDARAAGKGDLKLYAQDADGCPIDIKVIPNGDGTFRCSYVPTK 714

Query: 1704 PGDYEVSVKFNEEHIPDSPFVVPVASPSGDAR-RLTVSSLQESGLKVNQPASFAVSLNGA 1880
            P  + + + +   ++P SPF V V   S   R ++    ++++GLK N+P  F V  + A
Sbjct: 715  PIKHTIIISWGGVNVPKSPFRVNVGEGSHPERVKVYGPGVEKTGLKANEPTYFTVDCSEA 774

Query: 1881 -KGAIDAKVH------SPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPG 2039
             +G +   +        P+ A  +  + + D D + V++ P   G Y I V F    IP 
Sbjct: 775  GQGDVSIGIKCAPGVVGPAEADIDFDIIKNDNDTFTVKYTPPGAGRYTIMVLFANQEIPA 834

Query: 2040 SPFKIRVGEPGHGGDPGLVSAYGAGLE--GGVTGSPAEFIVNTSNAGAGALSVTIDGPSK 2213
            SPF I+V +P H  D   V A G GL   G   G P  F V T  AG   L V   G +K
Sbjct: 835  SPFHIKV-DPSH--DASKVKAEGPGLNRTGVEVGKPTHFTVLTKGAGKAKLDVHFAGAAK 891

Query: 2214 VKM-----DCQECPEGYRVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHS 2378
             +              Y V YT +  G+  +++ YGG   +  SPF   V          
Sbjct: 892  GEAVRDFEIIDNHDYSYTVKYTAVQQGNMAVTVTYGGD-PVPKSPFVVNVA--------- 941

Query: 2379 LHETSSVFVDSLTKTXXXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKA- 2555
                                           SKV  +GL  SK  VGQ+ +F+V+   A 
Sbjct: 942  --------------------------PPLDLSKVKVQGLN-SKVAVGQEQAFSVNTRGAG 974

Query: 2556 GNNMLLVGVHGP-RTPCEEILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRV 2732
            G   L V +  P R P    L    G+   +V Y+  ++G Y + + +    +PGSP+ V
Sbjct: 975  GQGQLDVRMTSPSRRPIPCKLEPGGGADAQAVRYMPPEEGPYKVDITYDGHPVPGSPFAV 1034


>ref|XP_003134749.1| PREDICTED: filamin-C isoform 3 [Sus scrofa].
          Length = 2583

 Score = 1354 bits (3505), Expect = 0.0
 Identities = 648/879 (73%), Positives = 763/879 (86%), Gaps = 3/879 (0%)
 Frame = +3

Query: 114  APERPLVGVNGLDVTSLRPFDLVIPFTIKKGEITGEVRMPSGKVAQPAITDNKDGTVTVR 293
            A E P+V V  ++ + LRPF+LVIPFT++KGE+TGEVRMPSGK A+P ITDNKDGT+TVR
Sbjct: 1706 ATEEPVVPVESME-SMLRPFNLVIPFTVQKGELTGEVRMPSGKTARPNITDNKDGTITVR 1764

Query: 294  YAPSEAGLHEMDIRYDNMHIPGSPLQFYVDYVNCGHVTAYGPGLSHGVVNKPAVFTVNTK 473
            YAP+E GLH+M I+YD  HIPGSPLQFYVD +N  HV+AYGPGLSHG+VNKPA FT+ TK
Sbjct: 1765 YAPTEKGLHQMGIKYDGNHIPGSPLQFYVDAINSRHVSAYGPGLSHGMVNKPATFTIVTK 1824

Query: 474  DAGEGGLSLAIEGPSKAEISCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTAR 653
            DAGEGGLSLA+EGPSKAEI+C DN+DGTC+VSYLP  PGDYSI+V+++++HIPGSPFTA+
Sbjct: 1825 DAGEGGLSLAVEGPSKAEITCKDNKDGTCTVSYLPTAPGDYSIIVRFDDKHIPGSPFTAK 1884

Query: 654  VTGDDSMRMSHLKVGSAADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISF 833
            +TGDDSMR S L VG++ D+ + I+E+DLS LTA++  PSG EEPCLLKRL N H+GISF
Sbjct: 1885 ITGDDSMRTSQLNVGTSTDVSLKITESDLSQLTASIRAPSGNEEPCLLKRLPNRHIGISF 1944

Query: 834  VPKETGEHLVHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEGHTFEPAEFIID 1013
             PKE GEH+V V+K+G+HV +SP  +++  SEIGDAS+VRV G+GL EG TF+ AEFI+D
Sbjct: 1945 TPKEVGEHVVSVRKSGKHVTNSPFKILVGPSEIGDASKVRVWGKGLSEGQTFQVAEFIVD 2004

Query: 1014 TRDAGYGGLSLSIEGPSKVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFS 1193
            TR+AGYGGL LSIEGPSKVDIN ED+EDGTC+VTYCPTEPG YIINIKFAD+HVPGSPF+
Sbjct: 2005 TRNAGYGGLGLSIEGPSKVDINCEDMEDGTCKVTYCPTEPGTYIINIKFADKHVPGSPFT 2064

Query: 1194 VKVTGEGRVKESITRRQRAPSVANVGSHCDLSLKIP-EISIQDMTAQVTSPSGKSHEAEI 1370
            VKVTGEGR+KESITRR++APS+A +GS CDL+LKIP E S QDMTAQVTSPSGK+  AEI
Sbjct: 2065 VKVTGEGRMKESITRRRQAPSIATIGSTCDLNLKIPGEASSQDMTAQVTSPSGKTEAAEI 2124

Query: 1371 VEGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLER 1550
            VEGE+  Y +RFVP EMG HTV+VKY+GQHVPGSPFQFTVGPLGEGGAHKVRAGG GLER
Sbjct: 2125 VEGEDSAYSVRFVPQEMGPHTVTVKYRGQHVPGSPFQFTVGPLGEGGAHKVRAGGTGLER 2184

Query: 1551 AEAGVPAEFSIWTREAGAGGLAIAVEGPSKAEISFEDRKDGSCGVAYVVQEPGDYEVSVK 1730
              AGVPAEFSIWTREAGAGGL+IAVEGPSKAEI+FEDRKDGSCGV+YVVQEPGDYEVS+K
Sbjct: 2185 GVAGVPAEFSIWTREAGAGGLSIAVEGPSKAEIAFEDRKDGSCGVSYVVQEPGDYEVSIK 2244

Query: 1731 FNEEHIPDSPFVVPVASPSGDARRLTVSSLQESGLKVNQPASFAVSLNGAKGAIDAKVHS 1910
            FN+EHIPDSPFVVPVAS S DARRLTV+SLQE+GLKVNQPASFAV LNGA+G IDA+VH+
Sbjct: 2245 FNDEHIPDSPFVVPVASLSDDARRLTVTSLQETGLKVNQPASFAVQLNGARGVIDARVHT 2304

Query: 1911 PSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPG 2090
            PSGA+EECYV+E+D DK+ +RFIP ENGV+ IDVKFNG HIPGSPFKIRVGE    GDPG
Sbjct: 2305 PSGAVEECYVSELDSDKHTIRFIPHENGVHSIDVKFNGAHIPGSPFKIRVGEQSQAGDPG 2364

Query: 2091 LVSAYGAGLEGGVTGSPAEFIVNTSNAGAGALSVTIDGPSKVKMDCQECPEGYRVTYTPM 2270
            LVSAYG GLEGG TG  +EFIVNT NAG+GALSVTIDGPSKV++DC+ECPEG+ VTYTPM
Sbjct: 2365 LVSAYGPGLEGGTTGVSSEFIVNTLNAGSGALSVTIDGPSKVQLDCRECPEGHVVTYTPM 2424

Query: 2271 APGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSVFVDSLTK--TXXXXXXX 2444
            APG+YLI+IKYGGP HI GSPFKA+VTG RL   HSLHETS+V V+++TK  +       
Sbjct: 2425 APGNYLIAIKYGGPQHIVGSPFKAKVTGPRLSGGHSLHETSTVLVETVTKSSSSRGSSYS 2484

Query: 2445 XXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKAGNNMLLVGVHGPRTPCEEILVKH 2624
                     SKV+ +G GLS+A+VGQK SFTVDCSKAG NM++VGVHGP+TPCEE+ VKH
Sbjct: 2485 SIPKFSSDASKVVTRGPGLSQAFVGQKNSFTVDCSKAGTNMMMVGVHGPKTPCEEVYVKH 2544

Query: 2625 VGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLVP 2741
            VG+R+Y+V+Y +K+KG+Y L+VKWGDE +PGSP++V VP
Sbjct: 2545 VGNRVYNVTYTVKEKGDYILIVKWGDESVPGSPFKVNVP 2583



 Score =  481 bits (1238), Expect = e-135
 Identities = 308/883 (34%), Positives = 453/883 (51%), Gaps = 18/883 (2%)
 Frame = +3

Query: 144  GLDVTSLRPFDLVIPFTIK-----KGEITGEVRMPSGKVAQPAITDNKDGTVTVRYAPSE 308
            GL+ + + P  L + FTI      +G +T ++  P GK  +  I DN DGT TV Y P  
Sbjct: 1528 GLNASGI-PASLPVEFTIDARDAGEGLLTVQILDPEGKPKKANIRDNGDGTYTVSYLPDM 1586

Query: 309  AGLHEMDIRYDNMHIPGSPLQFYV----DYVNCGHVTA-YGPGLSHGVVNKPAVFTVNTK 473
            +G + + I+Y    IP SP + +     D   C    A  GP +    + +  V TV+ K
Sbjct: 1587 SGRYTITIKYGGDEIPYSPFRIHALPTGDASKCLVTGACLGPRIQ---IGEETVITVDAK 1643

Query: 474  DAGEGGLSLAIEGPSKAE--ISCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFT 647
             AG+G ++  +  P  AE  +   +N DGT  + Y    PG Y I +++  +HIP SPF 
Sbjct: 1644 AAGKGKVTCTVSTPDGAELDVDVVENHDGTFDIYYTAPEPGKYVITIRFGGEHIPNSPFH 1703

Query: 648  ARVTGDDSM---RMSHLKVGSAADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGH 818
               T +  +    M  +       IP  + + +   LT  V  PSG+     +   ++G 
Sbjct: 1704 VLATEEPVVPVESMESMLRPFNLVIPFTVQKGE---LTGEVRMPSGKTARPNITDNKDGT 1760

Query: 819  VGISFVPKETGEHLVHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEGHTFEPA 998
            + + + P E G H + +K +G H+  SP+   +   +  ++  V   G GL  G   +PA
Sbjct: 1761 ITVRYAPTEKGLHQMGIKYDGNHIPGSPLQFYV---DAINSRHVSAYGPGLSHGMVNKPA 1817

Query: 999  EFIIDTRDAGYGGLSLSIEGPSKVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVP 1178
             F I T+DAG GGLSL++EGPSK +I  +D +DGTC V+Y PT PG+Y I ++F D+H+P
Sbjct: 1818 TFTIVTKDAGEGGLSLAVEGPSKAEITCKDNKDGTCTVSYLPTAPGDYSIIVRFDDKHIP 1877

Query: 1179 GSPFSVKVTGEGRVKESITRRQRAPSVANVGSHCDLSLKIPEISIQDMTAQVTSPSGKSH 1358
            GSPF+ K+TG+  ++          S  NVG+  D+SLKI E  +  +TA + +PSG   
Sbjct: 1878 GSPFTAKITGDDSMR---------TSQLNVGTSTDVSLKITESDLSQLTASIRAPSGNEE 1928

Query: 1359 EAEIVEGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGP 1538
               +    N    I F P E+G H VSV+  G+HV  SPF+  VGP   G A KVR  G 
Sbjct: 1929 PCLLKRLPNRHIGISFTPKEVGEHVVSVRKSGKHVTNSPFKILVGPSEIGDASKVRVWGK 1988

Query: 1539 GLERAEAGVPAEFSIWTREAGAGGLAIAVEGPSKAEISFEDRKDGSCGVAYVVQEPGDYE 1718
            GL   +    AEF + TR AG GGL +++EGPSK +I+ ED +DG+C V Y   EPG Y 
Sbjct: 1989 GLSEGQTFQVAEFIVDTRNAGYGGLGLSIEGPSKVDINCEDMEDGTCKVTYCPTEPGTYI 2048

Query: 1719 VSVKFNEEHIPDSPFVVPVASPSGDARRLTVSSLQESGLKVNQPASFAVSLNGAKGAID- 1895
            +++KF ++H+P SPF V V         +T      S   +       + + G   + D 
Sbjct: 2049 INIKFADKHVPGSPFTVKVTGEGRMKESITRRRQAPSIATIGSTCDLNLKIPGEASSQDM 2108

Query: 1896 -AKVHSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPG 2072
             A+V SPSG  E   + E +   Y+VRF+P+E G + + VK+ G H+PGSPF+  VG  G
Sbjct: 2109 TAQVTSPSGKTEAAEIVEGEDSAYSVRFVPQEMGPHTVTVKYRGQHVPGSPFQFTVGPLG 2168

Query: 2073 HGGDPGLVSAYGAGLEGGVTGSPAEFIVNTSNAGAGALSVTIDGPSKVKMDCQECPEG-Y 2249
             GG    V A G GLE GV G PAEF + T  AGAG LS+ ++GPSK ++  ++  +G  
Sbjct: 2169 EGG-AHKVRAGGTGLERGVAGVPAEFSIWTREAGAGGLSIAVEGPSKAEIAFEDRKDGSC 2227

Query: 2250 RVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSVFVDSLTKTXX 2429
             V+Y    PG Y +SIK+    HI  SPF   V     +S+ +   T    V SL +T  
Sbjct: 2228 GVSYVVQEPGDYEVSIKFNDE-HIPDSPFVVPVAS---LSDDARRLT----VTSLQET-- 2277

Query: 2430 XXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKAGNNMLLVGVHGPRTPCEE 2609
                                  GL    V Q  SF V  + A   ++   VH P    EE
Sbjct: 2278 ----------------------GLK---VNQPASFAVQLNGA-RGVIDARVHTPSGAVEE 2311

Query: 2610 ILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLV 2738
              V  + S  +++ ++  + G +++ VK+   HIPGSP+++ V
Sbjct: 2312 CYVSELDSDKHTIRFIPHENGVHSIDVKFNGAHIPGSPFKIRV 2354



 Score =  358 bits (919), Expect = 1e-98
 Identities = 278/885 (31%), Positives = 414/885 (46%), Gaps = 40/885 (4%)
 Frame = +3

Query: 204  GEITGEVRMPSGK--VAQPAITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFY 377
            G++   +  P G+    + A+ D  D T    Y P   G H + + +    I  SP   +
Sbjct: 388  GDVAVVIVDPQGRRDTVEVALEDKGDSTFRCTYRPVMEGPHTVHVAFAGAPITRSPFPVH 447

Query: 378  V-DYVNCGHVTAYGPGLS-HGV-VNKPAVFTVNTKDAGEGGLSLAIEGPSKAE--ISCTD 542
            V +  N     A G GL   GV V + A F V TK AG G L + ++GP   E  +   D
Sbjct: 448  VAEACNPNACRASGRGLQPKGVRVKEVADFKVFTKGAGSGELKVTVKGPKGTEEPVKVRD 507

Query: 543  NQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARVTGDDSMR--------MSHLKVG 698
              DG     Y PV+PG Y + + +    IP SPF  +V+ +  M+        +   +VG
Sbjct: 508  AGDGVFECEYYPVVPGKYVVTITWGGYAIPRSPFEVQVSPEAGMQKVRAWGPGLETGQVG 567

Query: 699  SAADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKN 878
             +AD  +    T++  L  ++  PS  +  C  K   +G   + + P E GE+ VHV  +
Sbjct: 568  KSADFVVEAIGTEVGTLGFSIEGPSQAKIECDDK--GDGSCDVRYWPTEPGEYAVHVICD 625

Query: 879  GQHVASSPIPVVISQSEIG-DASRVRVSGRGLHEGHTF--EPAEFIIDTRDAGYGGLSLS 1049
             + +  SP    I  +       +V+  G GL        +PAEF ID R AG G L L 
Sbjct: 626  DEDIRDSPFIAHIQPAPPDCFPDKVKAFGPGLEPTGCIVDKPAEFTIDARAAGKGDLKLY 685

Query: 1050 IEGPS--KVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTGEGRVK 1223
             +      +DI      DGT R +Y PT+P  + I I +   +VP SPF V V GEG   
Sbjct: 686  AQDADGCPIDIKVIPNGDGTFRCSYVPTKPIKHTIIISWGGVNVPKSPFRVNV-GEGSHP 744

Query: 1224 ESITRRQRAPSVANVGSHCD----LSLKIPEISIQDMT------AQVTSPSGKSHEAEIV 1373
            E +  +   P V   G   +     ++   E    D++        V  P+    + +I+
Sbjct: 745  ERV--KVYGPGVEKTGLKANEPTYFTVDCSEAGQGDVSIGIKCAPGVVGPAEADIDFDII 802

Query: 1374 EGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLER- 1550
            + +N T+ +++ P   G +T+ V +  Q +P SPF   V P  +  A KV+A GPGL R 
Sbjct: 803  KNDNDTFTVKYTPPGAGRYTIMVLFANQEIPASPFHIKVDPSHD--ASKVKAEGPGLNRT 860

Query: 1551 -AEAGVPAEFSIWTREAGAGGLAIAVEGPSKAEI--SFE--DRKDGSCGVAYVVQEPGDY 1715
              E G P  F++ T+ AG   L +   G +K E    FE  D  D S  V Y   + G+ 
Sbjct: 861  GVEVGKPTHFTVLTKGAGKAKLDVHFAGAAKGEAVRDFEIIDNHDYSYTVKYTAVQQGNM 920

Query: 1716 EVSVKFNEEHIPDSPFVVPVASPSGDARRLTVSSLQESGLKVNQPASFAVSLNGA--KGA 1889
             V+V +  + +P SPFVV VA P  D  ++ V  L  S + V Q  +F+V+  GA  +G 
Sbjct: 921  AVTVTYGGDPVPKSPFVVNVAPPL-DLSKVKVQGL-NSKVAVGQEQAFSVNTRGAGGQGQ 978

Query: 1890 IDAKVHSPSGALEECYVTE-IDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGE 2066
            +D ++ SPS     C +      D  AVR++P E G Y +D+ ++G  +PGSPF +    
Sbjct: 979  LDVRMTSPSRRPIPCKLEPGGGADAQAVRYMPPEEGPYKVDITYDGHPVPGSPFAVEGVL 1038

Query: 2067 PGHGGDPGLVSAYGAGLEGGVTGSPAEFIVNTSNAGAGALSVTIDGPSKVKMDCQECPEG 2246
            P    DP  V AYG GL+GG+ G+PA F ++T  AG G L +T++GP + K++CQ+  +G
Sbjct: 1039 P---PDPSKVCAYGPGLKGGLVGTPAPFSIDTKGAGTGGLGLTVEGPCEAKIECQDNGDG 1095

Query: 2247 -YRVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSVFVDSLTKT 2423
               V+Y P  PG Y I+I +    HI GSPFKA +                VF       
Sbjct: 1096 SCAVSYLPTEPGEYTINILF-AEAHIPGSPFKATI--------------RPVF------- 1133

Query: 2424 XXXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKAGNNMLLVGVHGPRTPC 2603
                            SKV A G GL +   G+  +FTVDCS+AG   L + +       
Sbjct: 1134 --------------DPSKVRASGPGLERGKAGEAATFTVDCSEAGEAELTIEILSDAGVK 1179

Query: 2604 EEILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLV 2738
             E+L+ +     Y ++Y     G YT+ +K+G   +P  P RV V
Sbjct: 1180 AEVLIHNNADGTYHITYSPAFPGTYTITIKYGGHPVPKFPTRVHV 1224



 Score =  324 bits (831), Expect = 2e-88
 Identities = 247/881 (28%), Positives = 399/881 (45%), Gaps = 35/881 (3%)
 Frame = +3

Query: 201  KGEITGEVRMPSGKVAQPAITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFYV 380
            + E+T E+   +G  A+  I +N DGT  + Y+P+  G + + I+Y    +P  P + +V
Sbjct: 1165 EAELTIEILSDAGVKAEVLIHNNADGTYHITYSPAFPGTYTITIKYGGHPVPKFPTRVHV 1224

Query: 381  D-YVNCGHVTAYGPGLS-HGVVNKPAV-FTVNTKD---AGEGGLSLAIEGPS--KAEISC 536
               V+   V   GPG+  HGV+ +    FTV+ +     G   ++  +  PS  K +   
Sbjct: 1225 QPAVDTSGVKVSGPGVEPHGVLREVTTEFTVDARSLTATGGNHVTARVLNPSGAKTDTYV 1284

Query: 537  TDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARVT-GDDSMRMSHL-------K 692
            TDN DGT  V Y     G + + V Y++  +P SPF   VT G D  R+           
Sbjct: 1285 TDNGDGTYRVQYTAYEEGVHLVEVLYDDVAVPKSPFRVGVTEGCDPTRVRAFGPGLEGGL 1344

Query: 693  VGSAADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVK 872
            V  A    +         L   +  PS  +  C  K  ++G   + ++P   G++ V++ 
Sbjct: 1345 VNKANRFTVETRGAGTGGLGLAIEGPSEAKMSC--KDNKDGSCTVEYIPFTPGDYDVNIT 1402

Query: 873  KNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEG-HTFEPAEFIIDTRDAGYGGLSLS 1049
              G+ +  SP  V +   ++ D  +V+ SG GL  G     P  F +D   AG   L ++
Sbjct: 1403 FGGRPIPGSPFRVPV--KDVVDPGKVKCSGPGLGAGVRARVPQTFTVDCSQAGRAPLQVA 1460

Query: 1050 IEGPSKV--DINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTGEGRVK 1223
            +  P+ V   +   D  DGT  V Y P   G Y + +K+ADQ VP SPF +KV       
Sbjct: 1461 VLSPTGVAEPVEVRDNGDGTHTVHYTPATDGPYTVAVKYADQEVPRSPFKIKVL---PAH 1517

Query: 1224 ESITRRQRAPSVANVGSHCDLSLKIPEISIQD-----MTAQVTSPSGKSHEAEIVEGENH 1388
            ++   R   P +   G    L ++   I  +D     +T Q+  P GK  +A I +  + 
Sbjct: 1518 DASKVRASGPGLNASGIPASLPVEF-TIDARDAGEGLLTVQILDPEGKPKKANIRDNGDG 1576

Query: 1389 TYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLERAEAGVP 1568
            TY + ++P   G +T+++KY G  +P SPF+    P G+     V     G  R + G  
Sbjct: 1577 TYTVSYLPDMSGRYTITIKYGGDEIPYSPFRIHALPTGDASKCLVTGACLG-PRIQIGEE 1635

Query: 1569 AEFSIWTREAGAGGLAIAVEGPSKAEISFE--DRKDGSCGVAYVVQEPGDYEVSVKFNEE 1742
               ++  + AG G +   V  P  AE+  +  +  DG+  + Y   EPG Y ++++F  E
Sbjct: 1636 TVITVDAKAAGKGKVTCTVSTPDGAELDVDVVENHDGTFDIYYTAPEPGKYVITIRFGGE 1695

Query: 1743 HIPDSPF--------VVPVASPSGDARRLTVSSLQESGLKVNQPASFAVSLNGAKGAIDA 1898
            HIP+SPF        VVPV S              ES L+   P +  +     KG +  
Sbjct: 1696 HIPNSPFHVLATEEPVVPVES-------------MESMLR---PFNLVIPFTVQKGELTG 1739

Query: 1899 KVHSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGHG 2078
            +V  PSG      +T+       VR+ P E G++ + +K++G HIPGSP +  V      
Sbjct: 1740 EVRMPSGKTARPNITDNKDGTITVRYAPTEKGLHQMGIKYDGNHIPGSPLQFYV----DA 1795

Query: 2079 GDPGLVSAYGAGLEGGVTGSPAEFIVNTSNAGAGALSVTIDGPSKVKMDCQECPEG-YRV 2255
             +   VSAYG GL  G+   PA F + T +AG G LS+ ++GPSK ++ C++  +G   V
Sbjct: 1796 INSRHVSAYGPGLSHGMVNKPATFTIVTKDAGEGGLSLAVEGPSKAEITCKDNKDGTCTV 1855

Query: 2256 TYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSVFVDSLTKTXXXX 2435
            +Y P APG Y I +++    HI GSPF A++TG                 D   +T    
Sbjct: 1856 SYLPTAPGDYSIIVRFDDK-HIPGSPFTAKITG-----------------DDSMRT---- 1893

Query: 2436 XXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKAGNNMLLVGVHGPRTPCEEIL 2615
                                  S+  VG     ++  +++  + L   +  P    E  L
Sbjct: 1894 ----------------------SQLNVGTSTDVSLKITESDLSQLTASIRAPSGNEEPCL 1931

Query: 2616 VKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLV 2738
            +K + +R   +S+  K+ GE+ + V+   +H+  SP+++LV
Sbjct: 1932 LKRLPNRHIGISFTPKEVGEHVVSVRKSGKHVTNSPFKILV 1972



 Score =  306 bits (783), Expect = 6e-83
 Identities = 267/894 (29%), Positives = 406/894 (45%), Gaps = 48/894 (5%)
 Frame = +3

Query: 201  KGEITGEVRMPSGKVAQPAITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFYV 380
            KG++    +   G      +  N DGT    Y P++   H + I +  +++P SP +  V
Sbjct: 679  KGDLKLYAQDADGCPIDIKVIPNGDGTFRCSYVPTKPIKHTIIISWGGVNVPKSPFRVNV 738

Query: 381  -DYVNCGHVTAYGPGLSHG--VVNKPAVFTVNTKDAGEGGLSLAIE------GPSKAEI- 530
             +  +   V  YGPG+       N+P  FTV+  +AG+G +S+ I+      GP++A+I 
Sbjct: 739  GEGSHPERVKVYGPGVEKTGLKANEPTYFTVDCSEAGQGDVSIGIKCAPGVVGPAEADID 798

Query: 531  -SCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARVTGDDSMRMSHLKVGSAA 707
                 N + T +V Y P   G Y+I+V +  Q IP SPF  +V  D S   S +K   A 
Sbjct: 799  FDIIKNDNDTFTVKYTPPGAGRYTIMVLFANQEIPASPFHIKV--DPSHDASKVK---AE 853

Query: 708  DIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVG-----------------ISFV 836
               +N +  ++   T   V   G  +  L         G                 + + 
Sbjct: 854  GPGLNRTGVEVGKPTHFTVLTKGAGKAKLDVHFAGAAKGEAVRDFEIIDNHDYSYTVKYT 913

Query: 837  PKETGEHLVHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEGHTFEPAEFIIDT 1016
              + G   V V   G  V  SP   V++ +   D S+V+V G         E A F ++T
Sbjct: 914  AVQQGNMAVTVTYGGDPVPKSPF--VVNVAPPLDLSKVKVQGLNSKVAVGQEQA-FSVNT 970

Query: 1017 RDA-GYGGLSLSIEGPSKVDINTEDLEDG----TCRVTYCPTEPGNYIINIKFADQHVPG 1181
            R A G G L + +  PS+  I  + LE G       V Y P E G Y ++I +    VPG
Sbjct: 971  RGAGGQGQLDVRMTSPSRRPIPCK-LEPGGGADAQAVRYMPPEEGPYKVDITYDGHPVPG 1029

Query: 1182 SPFSVKVTGEGRVKESITR-RQRAPSVAN--VGSHCDLSLKIPEISIQDMTAQVTSPSGK 1352
            SPF+V    EG +    ++     P +    VG+    S+         +   V  P   
Sbjct: 1030 SPFAV----EGVLPPDPSKVCAYGPGLKGGLVGTPAPFSIDTKGAGTGGLGLTVEGPCEA 1085

Query: 1353 SHEAEIVEGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAG 1532
              E +  +  + +  + ++P E G +T+++ +   H+PGSPF+ T+ P+ +    KVRA 
Sbjct: 1086 KIECQ--DNGDGSCAVSYLPTEPGEYTINILFAEAHIPGSPFKATIRPVFD--PSKVRAS 1141

Query: 1533 GPGLERAEAGVPAEFSIWTREAGAGGLAIAV--EGPSKAEISFEDRKDGSCGVAYVVQEP 1706
            GPGLER +AG  A F++   EAG   L I +  +   KAE+   +  DG+  + Y    P
Sbjct: 1142 GPGLERGKAGEAATFTVDCSEAGEAELTIEILSDAGVKAEVLIHNNADGTYHITYSPAFP 1201

Query: 1707 GDYEVSVKFNEEHIPDSPFVVPVASPSGDARRLTVS--SLQESGLKVNQPASFAV---SL 1871
            G Y +++K+    +P  P  V V  P+ D   + VS   ++  G+       F V   SL
Sbjct: 1202 GTYTITIKYGGHPVPKFPTRVHV-QPAVDTSGVKVSGPGVEPHGVLREVTTEFTVDARSL 1260

Query: 1872 NGAKG-AIDAKVHSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPF 2048
                G  + A+V +PSGA  + YVT+     Y V++   E GV+L++V ++   +P SPF
Sbjct: 1261 TATGGNHVTARVLNPSGAKTDTYVTDNGDGTYRVQYTAYEEGVHLVEVLYDDVAVPKSPF 1320

Query: 2049 KIRVGEPGHGGDPGLVSAYGAGLEGGVTGSPAEFIVNTSNAGAGALSVTIDGPSKVKMDC 2228
            ++ V E   G DP  V A+G GLEGG+      F V T  AG G L + I+GPS+ KM C
Sbjct: 1321 RVGVTE---GCDPTRVRAFGPGLEGGLVNKANRFTVETRGAGTGGLGLAIEGPSEAKMSC 1377

Query: 2229 QECPEG-YRVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSVFV 2405
            ++  +G   V Y P  PG Y ++I +GG   I GSPF+  V                  V
Sbjct: 1378 KDNKDGSCTVEYIPFTPGDYDVNITFGG-RPIPGSPFRVPVKD---------------VV 1421

Query: 2406 DSLTKTXXXXXXXXXXXXXXXXSKVLAKGLGLS---KAYVGQKGSFTVDCSKAGNNMLLV 2576
            D                      KV   G GL    +A V Q  +FTVDCS+AG   L V
Sbjct: 1422 D--------------------PGKVKCSGPGLGAGVRARVPQ--TFTVDCSQAGRAPLQV 1459

Query: 2577 GVHGPRTPCEEILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLV 2738
             V  P    E + V+  G   ++V Y     G YT+ VK+ D+ +P SP+++ V
Sbjct: 1460 AVLSPTGVAEPVEVRDNGDGTHTVHYTPATDGPYTVAVKYADQEVPRSPFKIKV 1513



 Score =  298 bits (763), Expect = 1e-80
 Identities = 247/895 (27%), Positives = 384/895 (42%), Gaps = 50/895 (5%)
 Frame = +3

Query: 204  GEITGEVRMPSGKVAQPAITDN--KDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFY 377
            GE+   +  P G   +  +  N  KD T  V Y P  AGLH++ + +   +I  SP +  
Sbjct: 288  GEVLVYIEDPEGHTEEAKVVPNNDKDRTYAVSYVPKVAGLHKVTVLFAGQNIERSPFEVN 347

Query: 378  VDYV--NCGHVTAYGPGLS--HGVVNKPAVFTVNTKDAGEGGLSLAIEGP----SKAEIS 533
            V     +   V+A GPGL     V NKP  F + T  AG G +++ I  P       E++
Sbjct: 348  VGMALGDANKVSARGPGLEPVGNVANKPTYFDIYTAGAGTGDVAVVIVDPQGRRDTVEVA 407

Query: 534  CTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARV----------TGDDSMRMS 683
              D  D T   +Y PV+ G +++ V +    I  SPF   V               ++  
Sbjct: 408  LEDKGDSTFRCTYRPVMEGPHTVHVAFAGAPITRSPFPVHVAEACNPNACRASGRGLQPK 467

Query: 684  HLKVGSAADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLV 863
             ++V   AD  +         L  TV  P G EEP  ++   +G     + P   G+++V
Sbjct: 468  GVRVKEVADFKVFTKGAGSGELKVTVKGPKGTEEPVKVRDAGDGVFECEYYPVVPGKYVV 527

Query: 864  HVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEGHTFEPAEFIIDTRDAGYGGLS 1043
             +   G  +  SP  V +S        +VR  G GL  G   + A+F+++      G L 
Sbjct: 528  TITWGGYAIPRSPFEVQVSPE--AGMQKVRAWGPGLETGQVGKSADFVVEAIGTEVGTLG 585

Query: 1044 LSIEGPSKVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTGEGRVK 1223
             SIEGPS+  I  +D  DG+C V Y PTEPG Y +++   D+ +  SPF   +  +    
Sbjct: 586  FSIEGPSQAKIECDDKGDGSCDVRYWPTEPGEYAVHVICDDEDIRDSPFIAHI--QPAPP 643

Query: 1224 ESITRRQRA------PSVANVGSHCDLSLKIPEISIQDMTAQVTSPSGKSHEAEIVEGEN 1385
            +    + +A      P+   V    + ++        D+        G   + +++   +
Sbjct: 644  DCFPDKVKAFGPGLEPTGCIVDKPAEFTIDARAAGKGDLKLYAQDADGCPIDIKVIPNGD 703

Query: 1386 HTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAH--KVRAGGPGLERA-- 1553
             T+   +VP +   HT+ + + G +VP SPF+  VG     G+H  +V+  GPG+E+   
Sbjct: 704  GTFRCSYVPTKPIKHTIIISWGGVNVPKSPFRVNVGE----GSHPERVKVYGPGVEKTGL 759

Query: 1554 EAGVPAEFSIWTREAGAGGLAIAVE------GPSKAEISFEDRK--DGSCGVAYVVQEPG 1709
            +A  P  F++   EAG G ++I ++      GP++A+I F+  K  + +  V Y     G
Sbjct: 760  KANEPTYFTVDCSEAGQGDVSIGIKCAPGVVGPAEADIDFDIIKNDNDTFTVKYTPPGAG 819

Query: 1710 DYEVSVKFNEEHIPDSPFVVPVASPSGDARRLTVS--SLQESGLKVNQPASFAVSLNGAK 1883
             Y + V F  + IP SPF + V  PS DA ++      L  +G++V +P  F V   GA 
Sbjct: 820  RYTIMVLFANQEIPASPFHIKV-DPSHDASKVKAEGPGLNRTGVEVGKPTHFTVLTKGA- 877

Query: 1884 GAIDAKVH----SPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFK 2051
            G     VH    +   A+ +  + +     Y V++   + G   + V + G  +P SPF 
Sbjct: 878  GKAKLDVHFAGAAKGEAVRDFEIIDNHDYSYTVKYTAVQQGNMAVTVTYGGDPVPKSPFV 937

Query: 2052 IRVGEPGHGGDPGLVSAYGAGLEGGVTGSPAEFIVNTSNAGA-GALSVTIDGPSKVKMDC 2228
            + V  P    D   V   G   +  V G    F VNT  AG  G L V +  PS+  + C
Sbjct: 938  VNVAPP---LDLSKVKVQGLNSKVAV-GQEQAFSVNTRGAGGQGQLDVRMTSPSRRPIPC 993

Query: 2229 QECPEG----YRVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSS 2396
            +  P G      V Y P   G Y + I Y G + + GSPF                    
Sbjct: 994  KLEPGGGADAQAVRYMPPEEGPYKVDITYDG-HPVPGSPFAVE----------------- 1035

Query: 2397 VFVDSLTKTXXXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKAGNNMLLV 2576
                                     SKV A G GL    VG    F++D   AG   L +
Sbjct: 1036 ------------------GVLPPDPSKVCAYGPGLKGGLVGTPAPFSIDTKGAGTGGLGL 1077

Query: 2577 GVHGPRTPCE-EILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLV 2738
             V G   PCE +I  +  G    +VSYL  + GEYT+ + + + HIPGSP++  +
Sbjct: 1078 TVEG---PCEAKIECQDNGDGSCAVSYLPTEPGEYTINILFAEAHIPGSPFKATI 1129



 Score =  274 bits (700), Expect = 2e-73
 Identities = 243/873 (27%), Positives = 374/873 (42%), Gaps = 40/873 (4%)
 Frame = +3

Query: 264  DNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFYVDYV--NC--GHVTAYGPGLSH 431
            D  DG+  VRY P+E G + + +  D+  I  SP   ++     +C    V A+GPGL  
Sbjct: 600  DKGDGSCDVRYWPTEPGEYAVHVICDDEDIRDSPFIAHIQPAPPDCFPDKVKAFGPGLEP 659

Query: 432  G--VVNKPAVFTVNTKDAGEGGLSLAIEGPSKA--EISCTDNQDGTCSVSYLPVLPGDYS 599
               +V+KPA FT++ + AG+G L L  +       +I    N DGT   SY+P  P  ++
Sbjct: 660  TGCIVDKPAEFTIDARAAGKGDLKLYAQDADGCPIDIKVIPNGDGTFRCSYVPTKPIKHT 719

Query: 600  ILVKYNEQHIPGSPFTARVTGDDS-----------MRMSHLKVGSAADIPINISET---D 737
            I++ +   ++P SPF   V G+ S           +  + LK        ++ SE    D
Sbjct: 720  IIISWGGVNVPKSPFRVNV-GEGSHPERVKVYGPGVEKTGLKANEPTYFTVDCSEAGQGD 778

Query: 738  LSL---LTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNGQHVASSPIP 908
            +S+       VV P+  +    + +  N    + + P   G + + V    Q + +SP  
Sbjct: 779  VSIGIKCAPGVVGPAEADIDFDIIKNDNDTFTVKYTPPGAGRYTIMVLFANQEIPASPFH 838

Query: 909  VVISQSEIGDASRVRVSGRGLHEG--HTFEPAEFIIDTRDAGYGGLSLSIEGPSKV---- 1070
            + +  S   DAS+V+  G GL+       +P  F + T+ AG   L +   G +K     
Sbjct: 839  IKVDPSH--DASKVKAEGPGLNRTGVEVGKPTHFTVLTKGAGKAKLDVHFAGAAKGEAVR 896

Query: 1071 DINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTGEGRVKESITRRQRA 1250
            D    D  D +  V Y   + GN  + + +    VP SPF V V     +  S  + Q  
Sbjct: 897  DFEIIDNHDYSYTVKYTAVQQGNMAVTVTYGGDPVPKSPFVVNVAPP--LDLSKVKVQGL 954

Query: 1251 PSVANVGSHCDLSLKIPEISIQ-DMTAQVTSPSGKSHEAEIVEGEN-HTYCIRFVPAEMG 1424
             S   VG     S+       Q  +  ++TSPS +    ++  G       +R++P E G
Sbjct: 955  NSKVAVGQEQAFSVNTRGAGGQGQLDVRMTSPSRRPIPCKLEPGGGADAQAVRYMPPEEG 1014

Query: 1425 MHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLERAEAGVPAEFSIWTREAGA 1604
             + V + Y G  VPGSPF   V  +      KV A GPGL+    G PA FSI T+ AG 
Sbjct: 1015 PYKVDITYDGHPVPGSPF--AVEGVLPPDPSKVCAYGPGLKGGLVGTPAPFSIDTKGAGT 1072

Query: 1605 GGLAIAVEGPSKAEISFEDRKDGSCGVAYVVQEPGDYEVSVKFNEEHIPDSPFVVPVASP 1784
            GGL + VEGP +A+I  +D  DGSC V+Y+  EPG+Y +++ F E HIP SPF   +  P
Sbjct: 1073 GGLGLTVEGPCEAKIECQDNGDGSCAVSYLPTEPGEYTINILFAEAHIPGSPFKATI-RP 1131

Query: 1785 SGDARRLTVSSLQESGLKVNQPASFAVSLNGA-KGAIDAKVHSPSGALEECYVTEIDQDK 1961
              D  ++  S       K  + A+F V  + A +  +  ++ S +G   E  +       
Sbjct: 1132 VFDPSKVRASGPGLERGKAGEAATFTVDCSEAGEAELTIEILSDAGVKAEVLIHNNADGT 1191

Query: 1962 YAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPGLVSAYGAGLEGGVTGSP 2141
            Y + + P   G Y I +K+ G  +P  P ++ V +P        VS  G    G +    
Sbjct: 1192 YHITYSPAFPGTYTITIKYGGHPVPKFPTRVHV-QPAVDTSGVKVSGPGVEPHGVLREVT 1250

Query: 2142 AEFIVNTSN---AGAGALSVTIDGPSKVKMDCQECPEG---YRVTYTPMAPGSYLISIKY 2303
             EF V+  +    G   ++  +  PS  K D      G   YRV YT    G +L+ + Y
Sbjct: 1251 TEFTVDARSLTATGGNHVTARVLNPSGAKTDTYVTDNGDGTYRVQYTAYEEGVHLVEVLY 1310

Query: 2304 GGPYHIGGSPFKARVTGHRLVSNHSLHETSSVFVDSLTKTXXXXXXXXXXXXXXXXSKVL 2483
                 +  SPF+  VT                                        ++V 
Sbjct: 1311 -DDVAVPKSPFRVGVT-----------------------------------EGCDPTRVR 1334

Query: 2484 AKGLGLSKAYVGQKGSFTVDCSKAGNNMLLVGVHGPRTPCEEILVKHVGSRLYSVSYLLK 2663
            A G GL    V +   FTV+   AG   L + + GP            GS   +V Y+  
Sbjct: 1335 AFGPGLEGGLVNKANRFTVETRGAGTGGLGLAIEGPSEAKMSCKDNKDGS--CTVEYIPF 1392

Query: 2664 DKGEYTLVVKWGDEHIPGSPYRVLVP*ALCPGQ 2762
              G+Y + + +G   IPGSP+RV V   + PG+
Sbjct: 1393 TPGDYDVNITFGGRPIPGSPFRVPVKDVVDPGK 1425



 Score =  236 bits (602), Expect = 6e-62
 Identities = 237/840 (28%), Positives = 367/840 (43%), Gaps = 47/840 (5%)
 Frame = +3

Query: 354  PGSPLQFYVDYVNCGHVTAYGPGLSH--GVVNKPAVFTVNTKDAGEGGLSLAIEGP---- 515
            PG+P++     +N     AYGPG+      V +PA FTV T DAG G + + IE P    
Sbjct: 244  PGAPVRS--KQLNPKKAIAYGPGIEPQGNTVLQPAHFTVQTVDAGVGEVLVYIEDPEGHT 301

Query: 516  SKAEISCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARV---TGDD---SMR 677
             +A++   +++D T +VSY+P + G + + V +  Q+I  SPF   V    GD    S R
Sbjct: 302  EEAKVVPNNDKDRTYAVSYVPKVAGLHKVTVLFAGQNIERSPFEVNVGMALGDANKVSAR 361

Query: 678  MSHLK-VGSAADIP----INISETDLSLLTATVVPPSGREE--PCLLKRLRNGHVGISFV 836
               L+ VG+ A+ P    I  +      +   +V P GR +     L+   +     ++ 
Sbjct: 362  GPGLEPVGNVANKPTYFDIYTAGAGTGDVAVVIVDPQGRRDTVEVALEDKGDSTFRCTYR 421

Query: 837  PKETGEHLVHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEG--HTFEPAEFII 1010
            P   G H VHV   G  +  SP PV +  +E  + +  R SGRGL        E A+F +
Sbjct: 422  PVMEGPHTVHVAFAGAPITRSPFPVHV--AEACNPNACRASGRGLQPKGVRVKEVADFKV 479

Query: 1011 DTRDAGYGGLSLSIEGPSKVD--INTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGS 1184
             T+ AG G L ++++GP   +  +   D  DG     Y P  PG Y++ I +    +P S
Sbjct: 480  FTKGAGSGELKVTVKGPKGTEEPVKVRDAGDGVFECEYYPVVPGKYVVTITWGGYAIPRS 539

Query: 1185 PFSVKVTGEGRVKESITRRQRAPSV--ANVGSHCDLSLKIPEISIQDMTAQVTSPSGKSH 1358
            PF V+V+ E  +++    R   P +    VG   D  ++     +  +   +  PS    
Sbjct: 540  PFEVQVSPEAGMQKV---RAWGPGLETGQVGKSADFVVEAIGTEVGTLGFSIEGPSQAKI 596

Query: 1359 EAEIVEGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPL-GEGGAHKVRAGG 1535
            E +  +  + +  +R+ P E G + V V    + +  SPF   + P   +    KV+A G
Sbjct: 597  ECD--DKGDGSCDVRYWPTEPGEYAVHVICDDEDIRDSPFIAHIQPAPPDCFPDKVKAFG 654

Query: 1536 PGLERAEAGV--PAEFSIWTREAGAGGLAIAVEGPSKAEISFE--DRKDGSCGVAYVVQE 1703
            PGLE     V  PAEF+I  R AG G L +  +      I  +     DG+   +YV  +
Sbjct: 655  PGLEPTGCIVDKPAEFTIDARAAGKGDLKLYAQDADGCPIDIKVIPNGDGTFRCSYVPTK 714

Query: 1704 PGDYEVSVKFNEEHIPDSPFVVPVASPSGDAR-RLTVSSLQESGLKVNQPASFAVSLNGA 1880
            P  + + + +   ++P SPF V V   S   R ++    ++++GLK N+P  F V  + A
Sbjct: 715  PIKHTIIISWGGVNVPKSPFRVNVGEGSHPERVKVYGPGVEKTGLKANEPTYFTVDCSEA 774

Query: 1881 -KGAIDAKVH------SPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPG 2039
             +G +   +        P+ A  +  + + D D + V++ P   G Y I V F    IP 
Sbjct: 775  GQGDVSIGIKCAPGVVGPAEADIDFDIIKNDNDTFTVKYTPPGAGRYTIMVLFANQEIPA 834

Query: 2040 SPFKIRVGEPGHGGDPGLVSAYGAGLE--GGVTGSPAEFIVNTSNAGAGALSVTIDGPSK 2213
            SPF I+V +P H  D   V A G GL   G   G P  F V T  AG   L V   G +K
Sbjct: 835  SPFHIKV-DPSH--DASKVKAEGPGLNRTGVEVGKPTHFTVLTKGAGKAKLDVHFAGAAK 891

Query: 2214 VKM-----DCQECPEGYRVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHS 2378
             +              Y V YT +  G+  +++ YGG   +  SPF   V          
Sbjct: 892  GEAVRDFEIIDNHDYSYTVKYTAVQQGNMAVTVTYGGD-PVPKSPFVVNVA--------- 941

Query: 2379 LHETSSVFVDSLTKTXXXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKA- 2555
                                           SKV  +GL  SK  VGQ+ +F+V+   A 
Sbjct: 942  --------------------------PPLDLSKVKVQGLN-SKVAVGQEQAFSVNTRGAG 974

Query: 2556 GNNMLLVGVHGP-RTPCEEILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRV 2732
            G   L V +  P R P    L    G+   +V Y+  ++G Y + + +    +PGSP+ V
Sbjct: 975  GQGQLDVRMTSPSRRPIPCKLEPGGGADAQAVRYMPPEEGPYKVDITYDGHPVPGSPFAV 1034


>ref|XP_003134747.1| PREDICTED: filamin-C isoform 1 [Sus scrofa].
          Length = 2720

 Score =  799 bits (2064), Expect = 0.0
 Identities = 442/856 (51%), Positives = 559/856 (65%), Gaps = 24/856 (2%)
 Frame = +3

Query: 246  AQPAITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFYVDYVNCGHVTAYGPGL 425
            A+    DNKDGT TV Y P+  G + + +R+D+ HIPGSP    +   +    +    G 
Sbjct: 1897 AEITCKDNKDGTCTVSYLPTAPGDYSIIVRFDDKHIPGSPFTAKITGDDSMRTSQLNVGT 1956

Query: 426  SHGVVNKPAVFTVNTKDAGEGGLSLAIEGPSKAEISCTDNQ--DGTCSVSYLPVLPGDYS 599
            S  V  K     +   D  +  L+ +I  PS  E  C   +  +    +S+ P   G++ 
Sbjct: 1957 STDVSLK-----ITESDLSQ--LTASIRAPSGNEEPCLLKRLPNRHIGISFTPKEVGEHV 2009

Query: 600  ILVKYNEQHIPGSPFTARV----TGDDSM------RMSHLKVGSAADIPINISETDLSLL 749
            + V+ + +H+  SPF   V     GD S        +S  +    A+  ++        L
Sbjct: 2010 VSVRKSGKHVTNSPFKILVGPSEIGDASKVRVWGKGLSEGQTFQVAEFIVDTRNAGYGGL 2069

Query: 750  TATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNGQHVASSPIPVVISQSE 929
              ++  PS  +  C  + + +G   +++ P E G +++++K   +HV  SP  V ++   
Sbjct: 2070 GLSIEGPSKVDINC--EDMEDGTCKVTYCPTEPGTYIINIKFADKHVPGSPFTVKVTGE- 2126

Query: 930  IGDASRVRVSGRGLHEGHTFEPAEFIIDTR---DAGYGGLSLSIEGPSKVDINTEDLEDG 1100
                 R++ S     +  +        D        +  +  + E  ++    +      
Sbjct: 2127 ----GRMKESITRRRQAPSIATIGSTCDLNLKIPGNWFQMVSAQERLTRTFTRSSHTYTR 2182

Query: 1101 TCRVTYCPTEPGNYIINIKFADQ-HVPGSPFSVKVTGEGRVKE------SITRRQRAPSV 1259
            T R     T  G     ++  +   V G PF   V G+   +E      SITR+Q     
Sbjct: 2183 TERTEISKTRGGETKREVRVEESTQVGGDPFPA-VFGDFLGRERLGSFGSITRQQEG--- 2238

Query: 1260 ANVGSHCDLSLKIPEISIQDMTAQVTSPSGKSHEAEIVEGENHTYCIRFVPAEMGMHTVS 1439
                          E S QDMTAQVTSPSGK+  AEIVEGE+  Y +RFVP EMG HTV+
Sbjct: 2239 --------------EASSQDMTAQVTSPSGKTEAAEIVEGEDSAYSVRFVPQEMGPHTVT 2284

Query: 1440 VKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLERAEAGVPAEFSIWTREAGAGGLAI 1619
            VKY+GQHVPGSPFQFTVGPLGEGGAHKVRAGG GLER  AGVPAEFSIWTREAGAGGL+I
Sbjct: 2285 VKYRGQHVPGSPFQFTVGPLGEGGAHKVRAGGTGLERGVAGVPAEFSIWTREAGAGGLSI 2344

Query: 1620 AVEGPSKAEISFEDRKDGSCGVAYVVQEPGDYEVSVKFNEEHIPDSPFVVPVASPSGDAR 1799
            AVEGPSKAEI+FEDRKDGSCGV+YVVQEPGDYEVS+KFN+EHIPDSPFVVPVAS S DAR
Sbjct: 2345 AVEGPSKAEIAFEDRKDGSCGVSYVVQEPGDYEVSIKFNDEHIPDSPFVVPVASLSDDAR 2404

Query: 1800 RLTVSSLQESGLKVNQPASFAVSLNGAKGAIDAKVHSPSGALEECYVTEIDQDKYAVRFI 1979
            RLTV+SLQE+GLKVNQPASFAV LNGA+G IDA+VH+PSGA+EECYV+E+D DK+ +RFI
Sbjct: 2405 RLTVTSLQETGLKVNQPASFAVQLNGARGVIDARVHTPSGAVEECYVSELDSDKHTIRFI 2464

Query: 1980 PRENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPGLVSAYGAGLEGGVTGSPAEFIVN 2159
            P ENGV+ IDVKFNG HIPGSPFKIRVGE    GDPGLVSAYG GLEGG TG  +EFIVN
Sbjct: 2465 PHENGVHSIDVKFNGAHIPGSPFKIRVGEQSQAGDPGLVSAYGPGLEGGTTGVSSEFIVN 2524

Query: 2160 TSNAGAGALSVTIDGPSKVKMDCQECPEGYRVTYTPMAPGSYLISIKYGGPYHIGGSPFK 2339
            T NAG+GALSVTIDGPSKV++DC+ECPEG+ VTYTPMAPG+YLI+IKYGGP HI GSPFK
Sbjct: 2525 TLNAGSGALSVTIDGPSKVQLDCRECPEGHVVTYTPMAPGNYLIAIKYGGPQHIVGSPFK 2584

Query: 2340 ARVTGHRLVSNHSLHETSSVFVDSLTK--TXXXXXXXXXXXXXXXXSKVLAKGLGLSKAY 2513
            A+VTG RL   HSLHETS+V V+++TK  +                SKV+ +G GLS+A+
Sbjct: 2585 AKVTGPRLSGGHSLHETSTVLVETVTKSSSSRGSSYSSIPKFSSDASKVVTRGPGLSQAF 2644

Query: 2514 VGQKGSFTVDCSKAGNNMLLVGVHGPRTPCEEILVKHVGSRLYSVSYLLKDKGEYTLVVK 2693
            VGQK SFTVDCSKAG NM++VGVHGP+TPCEE+ VKHVG+R+Y+V+Y +K+KG+Y L+VK
Sbjct: 2645 VGQKNSFTVDCSKAGTNMMMVGVHGPKTPCEEVYVKHVGNRVYNVTYTVKEKGDYILIVK 2704

Query: 2694 WGDEHIPGSPYRVLVP 2741
            WGDE +PGSP++V VP
Sbjct: 2705 WGDESVPGSPFKVNVP 2720



 Score =  701 bits (1810), Expect = 0.0
 Identities = 407/888 (45%), Positives = 527/888 (59%), Gaps = 12/888 (1%)
 Frame = +3

Query: 111  WAPERPLVGVNGLDVTSLRPFDLVIPFTIKKGEITGEVRMPSGKVAQPAITDNKDGTVTV 290
            WA E P+V V  ++ + LRPF+LVIPFT++KGE+TGEVRMPSGK A+P ITDNKDGT+TV
Sbjct: 1761 WATEEPVVPVESME-SMLRPFNLVIPFTVQKGELTGEVRMPSGKTARPNITDNKDGTITV 1819

Query: 291  RYAPSEAGLHEMDIRYDNMHIPGSPLQFYVDYVNCGHVTAYGPGLSHGVVNKPAVFTVNT 470
            RYAP+E GLH+M I+YD  HIPGSPLQFYVD +N  HV+AYGPGLSHG+VNKPA FT+ T
Sbjct: 1820 RYAPTEKGLHQMGIKYDGNHIPGSPLQFYVDAINSRHVSAYGPGLSHGMVNKPATFTIVT 1879

Query: 471  KDAGEGGLSLAIEGPSKAEISCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTA 650
            KDAGEGGLSLA+EGPSKAEI+C DN+DGTC+VSYLP  PGDYSI+V+++++HIPGSPFTA
Sbjct: 1880 KDAGEGGLSLAVEGPSKAEITCKDNKDGTCTVSYLPTAPGDYSIIVRFDDKHIPGSPFTA 1939

Query: 651  RVTGDDSMRMSHLKVGSAADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGIS 830
            ++TGDDSMR S L VG++ D+ + I+E+DLS LTA++  PSG EEPCLLKRL N H+GIS
Sbjct: 1940 KITGDDSMRTSQLNVGTSTDVSLKITESDLSQLTASIRAPSGNEEPCLLKRLPNRHIGIS 1999

Query: 831  FVPKETGEHLVHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEGHTFEPAEFII 1010
            F PKE GEH+V V+K+G+HV +SP  +++  SEIGDAS+VRV G+GL EG TF+ AEFI+
Sbjct: 2000 FTPKEVGEHVVSVRKSGKHVTNSPFKILVGPSEIGDASKVRVWGKGLSEGQTFQVAEFIV 2059

Query: 1011 DTRDAGYGGLSLSIEGPSKVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPF 1190
            DTR+AGYGGL LSIEGPSKVDIN ED+EDGTC+VTYCPTEPG YIINIKFAD+HVPGSPF
Sbjct: 2060 DTRNAGYGGLGLSIEGPSKVDINCEDMEDGTCKVTYCPTEPGTYIINIKFADKHVPGSPF 2119

Query: 1191 SVKVTGEGRVKESITRRQRAPSVANVGSHCDLSLKIPEISIQDMTAQVTSPSGKSHEAEI 1370
            +VKVTGEGR+KESITRR++APS+A +GS CDL+LKIP    Q ++AQ       +  +  
Sbjct: 2120 TVKVTGEGRMKESITRRRQAPSIATIGSTCDLNLKIPGNWFQMVSAQERLTRTFTRSSHT 2179

Query: 1371 VEGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPG-LE 1547
                  T   +    E     V V+   Q V G PF    G        + R G  G + 
Sbjct: 2180 YTRTERTEISKTRGGET-KREVRVEESTQ-VGGDPFPAVFGDF----LGRERLGSFGSIT 2233

Query: 1548 RAEAGVPAEFSIWTREAGAGGLAIAVEGPS-KAEIS-FEDRKDGSCGVAYVVQEPGDYEV 1721
            R + G          EA +  +   V  PS K E +   + +D +  V +V QE G + V
Sbjct: 2234 RQQEG----------EASSQDMTAQVTSPSGKTEAAEIVEGEDSAYSVRFVPQEMGPHTV 2283

Query: 1722 SVKFNEEHIPDSPFVVPVAS-PSGDARRLTVSSLQESGLKVNQPASFAV-SLNGAKGAID 1895
            +VK+  +H+P SPF   V     G A ++              PA F++ +     G + 
Sbjct: 2284 TVKYRGQHVPGSPFQFTVGPLGEGGAHKVRAGGTGLERGVAGVPAEFSIWTREAGAGGLS 2343

Query: 1896 AKVHSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGH 2075
              V  PS A  E    +       V ++ +E G Y + +KFN  HIP SPF + V     
Sbjct: 2344 IAVEGPSKA--EIAFEDRKDGSCGVSYVVQEPGDYEVSIKFNDEHIPDSPFVVPVA--SL 2399

Query: 2076 GGDPGLVSAYGAGLEGGVTGSPAEFIVNTSNAGAGALSVTIDGPSKVKMDC---QECPEG 2246
              D   ++       G     PA F V   N   G +   +  PS    +C   +   + 
Sbjct: 2400 SDDARRLTVTSLQETGLKVNQPASFAVQL-NGARGVIDARVHTPSGAVEECYVSELDSDK 2458

Query: 2247 YRVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSVFVDSLTKTX 2426
            + + + P   G + I +K+ G  HI GSPFK RV       +  L               
Sbjct: 2459 HTIRFIPHENGVHSIDVKFNGA-HIPGSPFKIRVGEQSQAGDPGL--------------- 2502

Query: 2427 XXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKAGNNMLLVGVHGP---RT 2597
                             V A G GL     G    F V+   AG+  L V + GP   + 
Sbjct: 2503 -----------------VSAYGPGLEGGTTGVSSEFIVNTLNAGSGALSVTIDGPSKVQL 2545

Query: 2598 PCEEILVKHVGSRLYSVSYLLKDKGEYTLVVKW-GDEHIPGSPYRVLV 2738
             C E    HV      V+Y     G Y + +K+ G +HI GSP++  V
Sbjct: 2546 DCRECPEGHV------VTYTPMAPGNYLIAIKYGGPQHIVGSPFKAKV 2587



 Score =  358 bits (919), Expect = 1e-98
 Identities = 278/885 (31%), Positives = 414/885 (46%), Gaps = 40/885 (4%)
 Frame = +3

Query: 204  GEITGEVRMPSGK--VAQPAITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFY 377
            G++   +  P G+    + A+ D  D T    Y P   G H + + +    I  SP   +
Sbjct: 409  GDVAVVIVDPQGRRDTVEVALEDKGDSTFRCTYRPVMEGPHTVHVAFAGAPITRSPFPVH 468

Query: 378  V-DYVNCGHVTAYGPGLS-HGV-VNKPAVFTVNTKDAGEGGLSLAIEGPSKAE--ISCTD 542
            V +  N     A G GL   GV V + A F V TK AG G L + ++GP   E  +   D
Sbjct: 469  VAEACNPNACRASGRGLQPKGVRVKEVADFKVFTKGAGSGELKVTVKGPKGTEEPVKVRD 528

Query: 543  NQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARVTGDDSMR--------MSHLKVG 698
              DG     Y PV+PG Y + + +    IP SPF  +V+ +  M+        +   +VG
Sbjct: 529  AGDGVFECEYYPVVPGKYVVTITWGGYAIPRSPFEVQVSPEAGMQKVRAWGPGLETGQVG 588

Query: 699  SAADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKN 878
             +AD  +    T++  L  ++  PS  +  C  K   +G   + + P E GE+ VHV  +
Sbjct: 589  KSADFVVEAIGTEVGTLGFSIEGPSQAKIECDDK--GDGSCDVRYWPTEPGEYAVHVICD 646

Query: 879  GQHVASSPIPVVISQSEIG-DASRVRVSGRGLHEGHTF--EPAEFIIDTRDAGYGGLSLS 1049
             + +  SP    I  +       +V+  G GL        +PAEF ID R AG G L L 
Sbjct: 647  DEDIRDSPFIAHIQPAPPDCFPDKVKAFGPGLEPTGCIVDKPAEFTIDARAAGKGDLKLY 706

Query: 1050 IEGPS--KVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTGEGRVK 1223
             +      +DI      DGT R +Y PT+P  + I I +   +VP SPF V V GEG   
Sbjct: 707  AQDADGCPIDIKVIPNGDGTFRCSYVPTKPIKHTIIISWGGVNVPKSPFRVNV-GEGSHP 765

Query: 1224 ESITRRQRAPSVANVGSHCD----LSLKIPEISIQDMT------AQVTSPSGKSHEAEIV 1373
            E +  +   P V   G   +     ++   E    D++        V  P+    + +I+
Sbjct: 766  ERV--KVYGPGVEKTGLKANEPTYFTVDCSEAGQGDVSIGIKCAPGVVGPAEADIDFDII 823

Query: 1374 EGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLER- 1550
            + +N T+ +++ P   G +T+ V +  Q +P SPF   V P  +  A KV+A GPGL R 
Sbjct: 824  KNDNDTFTVKYTPPGAGRYTIMVLFANQEIPASPFHIKVDPSHD--ASKVKAEGPGLNRT 881

Query: 1551 -AEAGVPAEFSIWTREAGAGGLAIAVEGPSKAEI--SFE--DRKDGSCGVAYVVQEPGDY 1715
              E G P  F++ T+ AG   L +   G +K E    FE  D  D S  V Y   + G+ 
Sbjct: 882  GVEVGKPTHFTVLTKGAGKAKLDVHFAGAAKGEAVRDFEIIDNHDYSYTVKYTAVQQGNM 941

Query: 1716 EVSVKFNEEHIPDSPFVVPVASPSGDARRLTVSSLQESGLKVNQPASFAVSLNGA--KGA 1889
             V+V +  + +P SPFVV VA P  D  ++ V  L  S + V Q  +F+V+  GA  +G 
Sbjct: 942  AVTVTYGGDPVPKSPFVVNVAPPL-DLSKVKVQGL-NSKVAVGQEQAFSVNTRGAGGQGQ 999

Query: 1890 IDAKVHSPSGALEECYVTE-IDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGE 2066
            +D ++ SPS     C +      D  AVR++P E G Y +D+ ++G  +PGSPF +    
Sbjct: 1000 LDVRMTSPSRRPIPCKLEPGGGADAQAVRYMPPEEGPYKVDITYDGHPVPGSPFAVEGVL 1059

Query: 2067 PGHGGDPGLVSAYGAGLEGGVTGSPAEFIVNTSNAGAGALSVTIDGPSKVKMDCQECPEG 2246
            P    DP  V AYG GL+GG+ G+PA F ++T  AG G L +T++GP + K++CQ+  +G
Sbjct: 1060 P---PDPSKVCAYGPGLKGGLVGTPAPFSIDTKGAGTGGLGLTVEGPCEAKIECQDNGDG 1116

Query: 2247 -YRVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSVFVDSLTKT 2423
               V+Y P  PG Y I+I +    HI GSPFKA +                VF       
Sbjct: 1117 SCAVSYLPTEPGEYTINILF-AEAHIPGSPFKATI--------------RPVF------- 1154

Query: 2424 XXXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKAGNNMLLVGVHGPRTPC 2603
                            SKV A G GL +   G+  +FTVDCS+AG   L + +       
Sbjct: 1155 --------------DPSKVRASGPGLERGKAGEAATFTVDCSEAGEAELTIEILSDAGVK 1200

Query: 2604 EEILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLV 2738
             E+L+ +     Y ++Y     G YT+ +K+G   +P  P RV V
Sbjct: 1201 AEVLIHNNADGTYHITYSPAFPGTYTITIKYGGHPVPKFPTRVHV 1245



 Score =  323 bits (827), Expect = 5e-88
 Identities = 250/900 (27%), Positives = 405/900 (45%), Gaps = 54/900 (6%)
 Frame = +3

Query: 201  KGEITGEVRMPSGKVAQPAITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFYV 380
            + E+T E+   +G  A+  I +N DGT  + Y+P+  G + + I+Y    +P  P + +V
Sbjct: 1186 EAELTIEILSDAGVKAEVLIHNNADGTYHITYSPAFPGTYTITIKYGGHPVPKFPTRVHV 1245

Query: 381  D-YVNCGHVTAYGPGLS-HGVVNKPAV-FTVNTKD---AGEGGLSLAIEGPS--KAEISC 536
               V+   V   GPG+  HGV+ +    FTV+ +     G   ++  +  PS  K +   
Sbjct: 1246 QPAVDTSGVKVSGPGVEPHGVLREVTTEFTVDARSLTATGGNHVTARVLNPSGAKTDTYV 1305

Query: 537  TDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARVT-GDDSMRMSHLKVG----- 698
            TDN DGT  V Y     G + + V Y++  +P SPF   VT G D  R+     G     
Sbjct: 1306 TDNGDGTYRVQYTAYEEGVHLVEVLYDDVAVPKSPFRVGVTEGCDPTRVRAFGPGLEGGL 1365

Query: 699  --SAADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVK 872
               A    +         L   +  PS  +  C  K  ++G   + ++P   G++ V++ 
Sbjct: 1366 VNKANRFTVETRGAGTGGLGLAIEGPSEAKMSC--KDNKDGSCTVEYIPFTPGDYDVNIT 1423

Query: 873  KNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEG-HTFEPAEFIIDTRDAGYGGLSLS 1049
              G+ +  SP  V +   ++ D  +V+ SG GL  G     P  F +D   AG   L ++
Sbjct: 1424 FGGRPIPGSPFRVPVK--DVVDPGKVKCSGPGLGAGVRARVPQTFTVDCSQAGRAPLQVA 1481

Query: 1050 IEGPSKV--DINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTGEGRVK 1223
            +  P+ V   +   D  DGT  V Y P   G Y + +K+ADQ VP SPF +KV       
Sbjct: 1482 VLSPTGVAEPVEVRDNGDGTHTVHYTPATDGPYTVAVKYADQEVPRSPFKIKVLP---AH 1538

Query: 1224 ESITRRQRAPSVANVGSHCDLSLKIPEISIQD-----MTAQVTSPSGKSHEAEIVEGENH 1388
            ++   R   P +   G    L ++   I  +D     +T Q+  P GK  +A I +  + 
Sbjct: 1539 DASKVRASGPGLNASGIPASLPVEFT-IDARDAGEGLLTVQILDPEGKPKKANIRDNGDG 1597

Query: 1389 TYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGG--AHKVRAGGPGL-----E 1547
            TY + ++P   G +T+++KY G  +P SPF+    P G+       V  GG GL      
Sbjct: 1598 TYTVSYLPDMSGRYTITIKYGGDEIPYSPFRIHALPTGDASKCLVTVSIGGHGLGACLGP 1657

Query: 1548 RAEAGVPAEFSIWTREAGAGGLAIAVEGPSKAEISFE--DRKDGSCGVAYVVQEPGDYEV 1721
            R + G     ++  + AG G +   V  P  AE+  +  +  DG+  + Y   EPG Y +
Sbjct: 1658 RIQIGEETVITVDAKAAGKGKVTCTVSTPDGAELDVDVVENHDGTFDIYYTAPEPGKYVI 1717

Query: 1722 SVKFNEEHIPDSPFVV--------------------PVASPSGDARRLTVSSLQESGLKV 1841
            +++F  EHIP+SPF V                    P A P+  A    V  + ES   +
Sbjct: 1718 TIRFGGEHIPNSPFHVLACDPMPHVEEPSEVLQLHRPSAYPTHWATEEPVVPV-ESMESM 1776

Query: 1842 NQPASFAVSLNGAKGAIDAKVHSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFN 2021
             +P +  +     KG +  +V  PSG      +T+       VR+ P E G++ + +K++
Sbjct: 1777 LRPFNLVIPFTVQKGELTGEVRMPSGKTARPNITDNKDGTITVRYAPTEKGLHQMGIKYD 1836

Query: 2022 GTHIPGSPFKIRVGEPGHGGDPGLVSAYGAGLEGGVTGSPAEFIVNTSNAGAGALSVTID 2201
            G HIPGSP +  V       +   VSAYG GL  G+   PA F + T +AG G LS+ ++
Sbjct: 1837 GNHIPGSPLQFYV----DAINSRHVSAYGPGLSHGMVNKPATFTIVTKDAGEGGLSLAVE 1892

Query: 2202 GPSKVKMDCQECPEG-YRVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHS 2378
            GPSK ++ C++  +G   V+Y P APG Y I +++    HI GSPF A++TG        
Sbjct: 1893 GPSKAEITCKDNKDGTCTVSYLPTAPGDYSIIVRFDDK-HIPGSPFTAKITG-------- 1943

Query: 2379 LHETSSVFVDSLTKTXXXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKAG 2558
                     D   +T                          S+  VG     ++  +++ 
Sbjct: 1944 ---------DDSMRT--------------------------SQLNVGTSTDVSLKITESD 1968

Query: 2559 NNMLLVGVHGPRTPCEEILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLV 2738
             + L   +  P    E  L+K + +R   +S+  K+ GE+ + V+   +H+  SP+++LV
Sbjct: 1969 LSQLTASIRAPSGNEEPCLLKRLPNRHIGISFTPKEVGEHVVSVRKSGKHVTNSPFKILV 2028



 Score =  320 bits (819), Expect = 4e-87
 Identities = 259/861 (30%), Positives = 386/861 (44%), Gaps = 35/861 (4%)
 Frame = +3

Query: 258  ITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFYV-DYVNCGHVTAYGPGLSHG 434
            I DN D + TV+Y   + G   + + Y    +P SP    V   ++   V   G   S  
Sbjct: 921  IIDNHDYSYTVKYTAVQQGNMAVTVTYGGDPVPKSPFVVNVAPPLDLSKVKVQGLN-SKV 979

Query: 435  VVNKPAVFTVNTKDAG-EGGLSLAIEGPSKAEISCTDNQDGTC---SVSYLPVLPGDYSI 602
             V +   F+VNT+ AG +G L + +  PS+  I C     G     +V Y+P   G Y +
Sbjct: 980  AVGQEQAFSVNTRGAGGQGQLDVRMTSPSRRPIPCKLEPGGGADAQAVRYMPPEEGPYKV 1039

Query: 603  LVKYNEQHIPGSPFTAR--VTGDDSMRMSH---LK---VGSAADIPINISETDLSLLTAT 758
             + Y+   +PGSPF     +  D S   ++   LK   VG+ A   I+        L  T
Sbjct: 1040 DITYDGHPVPGSPFAVEGVLPPDPSKVCAYGPGLKGGLVGTPAPFSIDTKGAGTGGLGLT 1099

Query: 759  VVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNGQHVASSPIPVVISQSEIGD 938
            V  P   +  C  +   +G   +S++P E GE+ +++     H+  SP    I    + D
Sbjct: 1100 VEGPCEAKIEC--QDNGDGSCAVSYLPTEPGEYTINILFAEAHIPGSPFKATIRP--VFD 1155

Query: 939  ASRVRVSGRGLHEGHTFEPAEFIIDTRDAGYGGLSLSI--EGPSKVDINTEDLEDGTCRV 1112
             S+VR SG GL  G   E A F +D  +AG   L++ I  +   K ++   +  DGT  +
Sbjct: 1156 PSKVRASGPGLERGKAGEAATFTVDCSEAGEAELTIEILSDAGVKAEVLIHNNADGTYHI 1215

Query: 1113 TYCPTEPGNYIINIKFADQHVPGSPF-----------SVKVTGEGRVKESITRRQRAPSV 1259
            TY P  PG Y I IK+    VP  P             VKV+G G     + R       
Sbjct: 1216 TYSPAFPGTYTITIKYGGHPVPKFPTRVHVQPAVDTSGVKVSGPGVEPHGVLREVTTEFT 1275

Query: 1260 ANVGSHCDLSLKIPEISIQDMTAQVTSPSGKSHEAEIVEGENHTYCIRFVPAEMGMHTVS 1439
             +  S       +       +TA+V +PSG   +  + +  + TY +++   E G+H V 
Sbjct: 1276 VDARS-------LTATGGNHVTARVLNPSGAKTDTYVTDNGDGTYRVQYTAYEEGVHLVE 1328

Query: 1440 VKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLERAEAGVPAEFSIWTREAGAGGLAI 1619
            V Y    VP SPF+  VG        +VRA GPGLE         F++ TR AG GGL +
Sbjct: 1329 VLYDDVAVPKSPFR--VGVTEGCDPTRVRAFGPGLEGGLVNKANRFTVETRGAGTGGLGL 1386

Query: 1620 AVEGPSKAEISFEDRKDGSCGVAYVVQEPGDYEVSVKFNEEHIPDSPFVVPVASPSGDAR 1799
            A+EGPS+A++S +D KDGSC V Y+   PGDY+V++ F    IP SPF VPV       +
Sbjct: 1387 AIEGPSEAKMSCKDNKDGSCTVEYIPFTPGDYDVNITFGGRPIPGSPFRVPVKDVVDPGK 1446

Query: 1800 RLTVSSLQESGLKVNQPASFAVSLNGA-KGAIDAKVHSPSGALEECYVTEIDQDKYAVRF 1976
                     +G++   P +F V  + A +  +   V SP+G  E   V +     + V +
Sbjct: 1447 VKCSGPGLGAGVRARVPQTFTVDCSQAGRAPLQVAVLSPTGVAEPVEVRDNGDGTHTVHY 1506

Query: 1977 IPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPGLVSAYGAGLE-GGVTGS-PAEF 2150
             P  +G Y + VK+    +P SPFKI+V  P H  D   V A G GL   G+  S P EF
Sbjct: 1507 TPATDGPYTVAVKYADQEVPRSPFKIKV-LPAH--DASKVRASGPGLNASGIPASLPVEF 1563

Query: 2151 IVNTSNAGAGALSVTIDGP--SKVKMDCQECPEG-YRVTYTPMAPGSYLISIKYGGPYHI 2321
             ++  +AG G L+V I  P     K + ++  +G Y V+Y P   G Y I+IKYGG   I
Sbjct: 1564 TIDARDAGEGLLTVQILDPEGKPKKANIRDNGDGTYTVSYLPDMSGRYTITIKYGGD-EI 1622

Query: 2322 GGSPFKARVTGHRLVSNHSLHETSSVFVDSLTKTXXXXXXXXXXXXXXXXSKVLAKGLGL 2501
              SPF+     H L +  +     +V +                            GLG 
Sbjct: 1623 PYSPFRI----HALPTGDASKCLVTVSIG-------------------------GHGLGA 1653

Query: 2502 ---SKAYVGQKGSFTVDCSKAGNNMLLVGVHGPRTPCEEILVKHVGSRLYSVSYLLKDKG 2672
                +  +G++   TVD   AG   +   V  P     ++ V       + + Y   + G
Sbjct: 1654 CLGPRIQIGEETVITVDAKAAGKGKVTCTVSTPDGAELDVDVVENHDGTFDIYYTAPEPG 1713

Query: 2673 EYTLVVKWGDEHIPGSPYRVL 2735
            +Y + +++G EHIP SP+ VL
Sbjct: 1714 KYVITIRFGGEHIPNSPFHVL 1734



 Score =  306 bits (783), Expect = 6e-83
 Identities = 267/894 (29%), Positives = 406/894 (45%), Gaps = 48/894 (5%)
 Frame = +3

Query: 201  KGEITGEVRMPSGKVAQPAITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFYV 380
            KG++    +   G      +  N DGT    Y P++   H + I +  +++P SP +  V
Sbjct: 700  KGDLKLYAQDADGCPIDIKVIPNGDGTFRCSYVPTKPIKHTIIISWGGVNVPKSPFRVNV 759

Query: 381  -DYVNCGHVTAYGPGLSHG--VVNKPAVFTVNTKDAGEGGLSLAIE------GPSKAEI- 530
             +  +   V  YGPG+       N+P  FTV+  +AG+G +S+ I+      GP++A+I 
Sbjct: 760  GEGSHPERVKVYGPGVEKTGLKANEPTYFTVDCSEAGQGDVSIGIKCAPGVVGPAEADID 819

Query: 531  -SCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARVTGDDSMRMSHLKVGSAA 707
                 N + T +V Y P   G Y+I+V +  Q IP SPF  +V  D S   S +K   A 
Sbjct: 820  FDIIKNDNDTFTVKYTPPGAGRYTIMVLFANQEIPASPFHIKV--DPSHDASKVK---AE 874

Query: 708  DIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVG-----------------ISFV 836
               +N +  ++   T   V   G  +  L         G                 + + 
Sbjct: 875  GPGLNRTGVEVGKPTHFTVLTKGAGKAKLDVHFAGAAKGEAVRDFEIIDNHDYSYTVKYT 934

Query: 837  PKETGEHLVHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEGHTFEPAEFIIDT 1016
              + G   V V   G  V  SP   V++ +   D S+V+V G         E A F ++T
Sbjct: 935  AVQQGNMAVTVTYGGDPVPKSPF--VVNVAPPLDLSKVKVQGLNSKVAVGQEQA-FSVNT 991

Query: 1017 RDA-GYGGLSLSIEGPSKVDINTEDLEDG----TCRVTYCPTEPGNYIINIKFADQHVPG 1181
            R A G G L + +  PS+  I  + LE G       V Y P E G Y ++I +    VPG
Sbjct: 992  RGAGGQGQLDVRMTSPSRRPIPCK-LEPGGGADAQAVRYMPPEEGPYKVDITYDGHPVPG 1050

Query: 1182 SPFSVKVTGEGRVKESITR-RQRAPSVAN--VGSHCDLSLKIPEISIQDMTAQVTSPSGK 1352
            SPF+V    EG +    ++     P +    VG+    S+         +   V  P   
Sbjct: 1051 SPFAV----EGVLPPDPSKVCAYGPGLKGGLVGTPAPFSIDTKGAGTGGLGLTVEGPCEA 1106

Query: 1353 SHEAEIVEGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAG 1532
              E +  +  + +  + ++P E G +T+++ +   H+PGSPF+ T+ P+ +    KVRA 
Sbjct: 1107 KIECQ--DNGDGSCAVSYLPTEPGEYTINILFAEAHIPGSPFKATIRPVFD--PSKVRAS 1162

Query: 1533 GPGLERAEAGVPAEFSIWTREAGAGGLAIAV--EGPSKAEISFEDRKDGSCGVAYVVQEP 1706
            GPGLER +AG  A F++   EAG   L I +  +   KAE+   +  DG+  + Y    P
Sbjct: 1163 GPGLERGKAGEAATFTVDCSEAGEAELTIEILSDAGVKAEVLIHNNADGTYHITYSPAFP 1222

Query: 1707 GDYEVSVKFNEEHIPDSPFVVPVASPSGDARRLTVS--SLQESGLKVNQPASFAV---SL 1871
            G Y +++K+    +P  P  V V  P+ D   + VS   ++  G+       F V   SL
Sbjct: 1223 GTYTITIKYGGHPVPKFPTRVHV-QPAVDTSGVKVSGPGVEPHGVLREVTTEFTVDARSL 1281

Query: 1872 NGAKG-AIDAKVHSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPF 2048
                G  + A+V +PSGA  + YVT+     Y V++   E GV+L++V ++   +P SPF
Sbjct: 1282 TATGGNHVTARVLNPSGAKTDTYVTDNGDGTYRVQYTAYEEGVHLVEVLYDDVAVPKSPF 1341

Query: 2049 KIRVGEPGHGGDPGLVSAYGAGLEGGVTGSPAEFIVNTSNAGAGALSVTIDGPSKVKMDC 2228
            ++ V E   G DP  V A+G GLEGG+      F V T  AG G L + I+GPS+ KM C
Sbjct: 1342 RVGVTE---GCDPTRVRAFGPGLEGGLVNKANRFTVETRGAGTGGLGLAIEGPSEAKMSC 1398

Query: 2229 QECPEG-YRVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSVFV 2405
            ++  +G   V Y P  PG Y ++I +GG   I GSPF+  V                  V
Sbjct: 1399 KDNKDGSCTVEYIPFTPGDYDVNITFGG-RPIPGSPFRVPVKD---------------VV 1442

Query: 2406 DSLTKTXXXXXXXXXXXXXXXXSKVLAKGLGLS---KAYVGQKGSFTVDCSKAGNNMLLV 2576
            D                      KV   G GL    +A V Q  +FTVDCS+AG   L V
Sbjct: 1443 D--------------------PGKVKCSGPGLGAGVRARVPQ--TFTVDCSQAGRAPLQV 1480

Query: 2577 GVHGPRTPCEEILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLV 2738
             V  P    E + V+  G   ++V Y     G YT+ VK+ D+ +P SP+++ V
Sbjct: 1481 AVLSPTGVAEPVEVRDNGDGTHTVHYTPATDGPYTVAVKYADQEVPRSPFKIKV 1534



 Score =  298 bits (763), Expect = 1e-80
 Identities = 247/895 (27%), Positives = 384/895 (42%), Gaps = 50/895 (5%)
 Frame = +3

Query: 204  GEITGEVRMPSGKVAQPAITDN--KDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFY 377
            GE+   +  P G   +  +  N  KD T  V Y P  AGLH++ + +   +I  SP +  
Sbjct: 309  GEVLVYIEDPEGHTEEAKVVPNNDKDRTYAVSYVPKVAGLHKVTVLFAGQNIERSPFEVN 368

Query: 378  VDYV--NCGHVTAYGPGLS--HGVVNKPAVFTVNTKDAGEGGLSLAIEGP----SKAEIS 533
            V     +   V+A GPGL     V NKP  F + T  AG G +++ I  P       E++
Sbjct: 369  VGMALGDANKVSARGPGLEPVGNVANKPTYFDIYTAGAGTGDVAVVIVDPQGRRDTVEVA 428

Query: 534  CTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARV----------TGDDSMRMS 683
              D  D T   +Y PV+ G +++ V +    I  SPF   V               ++  
Sbjct: 429  LEDKGDSTFRCTYRPVMEGPHTVHVAFAGAPITRSPFPVHVAEACNPNACRASGRGLQPK 488

Query: 684  HLKVGSAADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLV 863
             ++V   AD  +         L  TV  P G EEP  ++   +G     + P   G+++V
Sbjct: 489  GVRVKEVADFKVFTKGAGSGELKVTVKGPKGTEEPVKVRDAGDGVFECEYYPVVPGKYVV 548

Query: 864  HVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEGHTFEPAEFIIDTRDAGYGGLS 1043
             +   G  +  SP  V +S        +VR  G GL  G   + A+F+++      G L 
Sbjct: 549  TITWGGYAIPRSPFEVQVSPE--AGMQKVRAWGPGLETGQVGKSADFVVEAIGTEVGTLG 606

Query: 1044 LSIEGPSKVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTGEGRVK 1223
             SIEGPS+  I  +D  DG+C V Y PTEPG Y +++   D+ +  SPF   +  +    
Sbjct: 607  FSIEGPSQAKIECDDKGDGSCDVRYWPTEPGEYAVHVICDDEDIRDSPFIAHI--QPAPP 664

Query: 1224 ESITRRQRA------PSVANVGSHCDLSLKIPEISIQDMTAQVTSPSGKSHEAEIVEGEN 1385
            +    + +A      P+   V    + ++        D+        G   + +++   +
Sbjct: 665  DCFPDKVKAFGPGLEPTGCIVDKPAEFTIDARAAGKGDLKLYAQDADGCPIDIKVIPNGD 724

Query: 1386 HTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAH--KVRAGGPGLERA-- 1553
             T+   +VP +   HT+ + + G +VP SPF+  VG     G+H  +V+  GPG+E+   
Sbjct: 725  GTFRCSYVPTKPIKHTIIISWGGVNVPKSPFRVNVGE----GSHPERVKVYGPGVEKTGL 780

Query: 1554 EAGVPAEFSIWTREAGAGGLAIAVE------GPSKAEISFEDRK--DGSCGVAYVVQEPG 1709
            +A  P  F++   EAG G ++I ++      GP++A+I F+  K  + +  V Y     G
Sbjct: 781  KANEPTYFTVDCSEAGQGDVSIGIKCAPGVVGPAEADIDFDIIKNDNDTFTVKYTPPGAG 840

Query: 1710 DYEVSVKFNEEHIPDSPFVVPVASPSGDARRLTVS--SLQESGLKVNQPASFAVSLNGAK 1883
             Y + V F  + IP SPF + V  PS DA ++      L  +G++V +P  F V   GA 
Sbjct: 841  RYTIMVLFANQEIPASPFHIKV-DPSHDASKVKAEGPGLNRTGVEVGKPTHFTVLTKGA- 898

Query: 1884 GAIDAKVH----SPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFK 2051
            G     VH    +   A+ +  + +     Y V++   + G   + V + G  +P SPF 
Sbjct: 899  GKAKLDVHFAGAAKGEAVRDFEIIDNHDYSYTVKYTAVQQGNMAVTVTYGGDPVPKSPFV 958

Query: 2052 IRVGEPGHGGDPGLVSAYGAGLEGGVTGSPAEFIVNTSNAGA-GALSVTIDGPSKVKMDC 2228
            + V  P    D   V   G   +  V G    F VNT  AG  G L V +  PS+  + C
Sbjct: 959  VNVAPP---LDLSKVKVQGLNSKVAV-GQEQAFSVNTRGAGGQGQLDVRMTSPSRRPIPC 1014

Query: 2229 QECPEG----YRVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSS 2396
            +  P G      V Y P   G Y + I Y G + + GSPF                    
Sbjct: 1015 KLEPGGGADAQAVRYMPPEEGPYKVDITYDG-HPVPGSPFAVE----------------- 1056

Query: 2397 VFVDSLTKTXXXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKAGNNMLLV 2576
                                     SKV A G GL    VG    F++D   AG   L +
Sbjct: 1057 ------------------GVLPPDPSKVCAYGPGLKGGLVGTPAPFSIDTKGAGTGGLGL 1098

Query: 2577 GVHGPRTPCE-EILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLV 2738
             V G   PCE +I  +  G    +VSYL  + GEYT+ + + + HIPGSP++  +
Sbjct: 1099 TVEG---PCEAKIECQDNGDGSCAVSYLPTEPGEYTINILFAEAHIPGSPFKATI 1150



 Score =  273 bits (697), Expect = 5e-73
 Identities = 172/478 (35%), Positives = 241/478 (50%), Gaps = 50/478 (10%)
 Frame = +3

Query: 207  EITGEVRMPSGKVAQPAITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFYVDY 386
            ++T +V  PSGK     I + +D   +VR+ P E G H + ++Y   H+PGSP QF V  
Sbjct: 2244 DMTAQVTSPSGKTEAAEIVEGEDSAYSVRFVPQEMGPHTVTVKYRGQHVPGSPFQFTVGP 2303

Query: 387  VNCG---HVTAYGPGLSHGVVNKPAVFTVNTKDAGEGGLSLAIEGPSKAEISCTDNQDGT 557
            +  G    V A G GL  GV   PA F++ T++AG GGLS+A+EGPSKAEI+  D +DG+
Sbjct: 2304 LGEGGAHKVRAGGTGLERGVAGVPAEFSIWTREAGAGGLSIAVEGPSKAEIAFEDRKDGS 2363

Query: 558  CSVSYLPVLPGDYSILVKYNEQHIPGSPFTARVTG--DDSMRMS-------HLKVGSAAD 710
            C VSY+   PGDY + +K+N++HIP SPF   V    DD+ R++        LKV   A 
Sbjct: 2364 CGVSYVVQEPGDYEVSIKFNDEHIPDSPFVVPVASLSDDARRLTVTSLQETGLKVNQPAS 2423

Query: 711  IPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNGQHV 890
              + ++     ++ A V  PSG  E C +  L +    I F+P E G H + VK NG H+
Sbjct: 2424 FAVQLNGAR-GVIDARVHTPSGAVEECYVSELDSDKHTIRFIPHENGVHSIDVKFNGAHI 2482

Query: 891  ASSPIPVVIS-QSEIGDASRVRVSGRGLHEGHTFEPAEFIIDTRDAGYGGLSLSIEGPSK 1067
              SP  + +  QS+ GD   V   G GL  G T   +EFI++T +AG G LS++I+GPSK
Sbjct: 2483 PGSPFKIRVGEQSQAGDPGLVSAYGPGLEGGTTGVSSEFIVNTLNAGSGALSVTIDGPSK 2542

Query: 1068 VDINTEDLEDGTCRVTYCPTEPGNYIINIKF-ADQHVPGSPFSVKVTG------------ 1208
            V ++  +  +G   VTY P  PGNY+I IK+   QH+ GSPF  KVTG            
Sbjct: 2543 VQLDCRECPEGHV-VTYTPMAPGNYLIAIKYGGPQHIVGSPFKAKVTGPRLSGGHSLHET 2601

Query: 1209 -----EGRVKESITRRQ-----------------RAP--SVANVGSHCDLSLKIPEISIQ 1316
                 E   K S +R                   R P  S A VG     ++   +    
Sbjct: 2602 STVLVETVTKSSSSRGSSYSSIPKFSSDASKVVTRGPGLSQAFVGQKNSFTVDCSKAGTN 2661

Query: 1317 DMTAQVTSPSGKSHEAEIVEGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTV 1490
             M   V  P     E  +    N  Y + +   E G + + VK+  + VPGSPF+  V
Sbjct: 2662 MMMVGVHGPKTPCEEVYVKHVGNRVYNVTYTVKEKGDYILIVKWGDESVPGSPFKVNV 2719



 Score =  236 bits (602), Expect = 6e-62
 Identities = 237/840 (28%), Positives = 367/840 (43%), Gaps = 47/840 (5%)
 Frame = +3

Query: 354  PGSPLQFYVDYVNCGHVTAYGPGLSH--GVVNKPAVFTVNTKDAGEGGLSLAIEGP---- 515
            PG+P++     +N     AYGPG+      V +PA FTV T DAG G + + IE P    
Sbjct: 265  PGAPVRS--KQLNPKKAIAYGPGIEPQGNTVLQPAHFTVQTVDAGVGEVLVYIEDPEGHT 322

Query: 516  SKAEISCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARV---TGDD---SMR 677
             +A++   +++D T +VSY+P + G + + V +  Q+I  SPF   V    GD    S R
Sbjct: 323  EEAKVVPNNDKDRTYAVSYVPKVAGLHKVTVLFAGQNIERSPFEVNVGMALGDANKVSAR 382

Query: 678  MSHLK-VGSAADIP----INISETDLSLLTATVVPPSGREE--PCLLKRLRNGHVGISFV 836
               L+ VG+ A+ P    I  +      +   +V P GR +     L+   +     ++ 
Sbjct: 383  GPGLEPVGNVANKPTYFDIYTAGAGTGDVAVVIVDPQGRRDTVEVALEDKGDSTFRCTYR 442

Query: 837  PKETGEHLVHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEG--HTFEPAEFII 1010
            P   G H VHV   G  +  SP PV +  +E  + +  R SGRGL        E A+F +
Sbjct: 443  PVMEGPHTVHVAFAGAPITRSPFPVHV--AEACNPNACRASGRGLQPKGVRVKEVADFKV 500

Query: 1011 DTRDAGYGGLSLSIEGPSKVD--INTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGS 1184
             T+ AG G L ++++GP   +  +   D  DG     Y P  PG Y++ I +    +P S
Sbjct: 501  FTKGAGSGELKVTVKGPKGTEEPVKVRDAGDGVFECEYYPVVPGKYVVTITWGGYAIPRS 560

Query: 1185 PFSVKVTGEGRVKESITRRQRAPSV--ANVGSHCDLSLKIPEISIQDMTAQVTSPSGKSH 1358
            PF V+V+ E  +++    R   P +    VG   D  ++     +  +   +  PS    
Sbjct: 561  PFEVQVSPEAGMQKV---RAWGPGLETGQVGKSADFVVEAIGTEVGTLGFSIEGPSQAKI 617

Query: 1359 EAEIVEGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPL-GEGGAHKVRAGG 1535
            E +  +  + +  +R+ P E G + V V    + +  SPF   + P   +    KV+A G
Sbjct: 618  ECD--DKGDGSCDVRYWPTEPGEYAVHVICDDEDIRDSPFIAHIQPAPPDCFPDKVKAFG 675

Query: 1536 PGLERAEAGV--PAEFSIWTREAGAGGLAIAVEGPSKAEISFE--DRKDGSCGVAYVVQE 1703
            PGLE     V  PAEF+I  R AG G L +  +      I  +     DG+   +YV  +
Sbjct: 676  PGLEPTGCIVDKPAEFTIDARAAGKGDLKLYAQDADGCPIDIKVIPNGDGTFRCSYVPTK 735

Query: 1704 PGDYEVSVKFNEEHIPDSPFVVPVASPSGDAR-RLTVSSLQESGLKVNQPASFAVSLNGA 1880
            P  + + + +   ++P SPF V V   S   R ++    ++++GLK N+P  F V  + A
Sbjct: 736  PIKHTIIISWGGVNVPKSPFRVNVGEGSHPERVKVYGPGVEKTGLKANEPTYFTVDCSEA 795

Query: 1881 -KGAIDAKVH------SPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPG 2039
             +G +   +        P+ A  +  + + D D + V++ P   G Y I V F    IP 
Sbjct: 796  GQGDVSIGIKCAPGVVGPAEADIDFDIIKNDNDTFTVKYTPPGAGRYTIMVLFANQEIPA 855

Query: 2040 SPFKIRVGEPGHGGDPGLVSAYGAGLE--GGVTGSPAEFIVNTSNAGAGALSVTIDGPSK 2213
            SPF I+V +P H  D   V A G GL   G   G P  F V T  AG   L V   G +K
Sbjct: 856  SPFHIKV-DPSH--DASKVKAEGPGLNRTGVEVGKPTHFTVLTKGAGKAKLDVHFAGAAK 912

Query: 2214 VKM-----DCQECPEGYRVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHS 2378
             +              Y V YT +  G+  +++ YGG   +  SPF   V          
Sbjct: 913  GEAVRDFEIIDNHDYSYTVKYTAVQQGNMAVTVTYGGD-PVPKSPFVVNVA--------- 962

Query: 2379 LHETSSVFVDSLTKTXXXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKA- 2555
                                           SKV  +GL  SK  VGQ+ +F+V+   A 
Sbjct: 963  --------------------------PPLDLSKVKVQGLN-SKVAVGQEQAFSVNTRGAG 995

Query: 2556 GNNMLLVGVHGP-RTPCEEILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRV 2732
            G   L V +  P R P    L    G+   +V Y+  ++G Y + + +    +PGSP+ V
Sbjct: 996  GQGQLDVRMTSPSRRPIPCKLEPGGGADAQAVRYMPPEEGPYKVDITYDGHPVPGSPFAV 1055



 Score =  130 bits (327), Expect = 4e-30
 Identities = 91/311 (29%), Positives = 139/311 (44%), Gaps = 53/311 (17%)
 Frame = +3

Query: 138  VNGLDVTSLR---PFDLVIPFTIKKGEITGEVRMPSGKVAQPAITDNKDGTVTVRYAPSE 308
            V  L  T L+   P    +     +G I   V  PSG V +  +++      T+R+ P E
Sbjct: 2408 VTSLQETGLKVNQPASFAVQLNGARGVIDARVHTPSGAVEECYVSELDSDKHTIRFIPHE 2467

Query: 309  AGLHEMDIRYDNMHIPGSPLQFYVDYVNC----GHVTAYGPGLSHGVVNKPAVFTVNTKD 476
             G+H +D++++  HIPGSP +  V   +     G V+AYGPGL  G     + F VNT +
Sbjct: 2468 NGVHSIDVKFNGAHIPGSPFKIRVGEQSQAGDPGLVSAYGPGLEGGTTGVSSEFIVNTLN 2527

Query: 477  AGEGGLSLAIEGPSKAEISCTDNQDGTCSVSYLPVLPGDYSILVKY-NEQHIPGSPFTAR 653
            AG G LS+ I+GPSK ++ C +  +G   V+Y P+ PG+Y I +KY   QHI GSPF A+
Sbjct: 2528 AGSGALSVTIDGPSKVQLDCRECPEGHV-VTYTPMAPGNYLIAIKYGGPQHIVGSPFKAK 2586

Query: 654  VTG----------------------DDSMR-----------------------MSHLKVG 698
            VTG                        S R                       +S   VG
Sbjct: 2587 VTGPRLSGGHSLHETSTVLVETVTKSSSSRGSSYSSIPKFSSDASKVVTRGPGLSQAFVG 2646

Query: 699  SAADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKN 878
                  ++ S+   +++   V  P    E   +K + N    +++  KE G++++ VK  
Sbjct: 2647 QKNSFTVDCSKAGTNMMMVGVHGPKTPCEEVYVKHVGNRVYNVTYTVKEKGDYILIVKWG 2706

Query: 879  GQHVASSPIPV 911
             + V  SP  V
Sbjct: 2707 DESVPGSPFKV 2717


>ref|XP_003134748.1| PREDICTED: filamin-C isoform 2 [Sus scrofa].
          Length = 2693

 Score =  799 bits (2064), Expect = 0.0
 Identities = 442/856 (51%), Positives = 559/856 (65%), Gaps = 24/856 (2%)
 Frame = +3

Query: 246  AQPAITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFYVDYVNCGHVTAYGPGL 425
            A+    DNKDGT TV Y P+  G + + +R+D+ HIPGSP    +   +    +    G 
Sbjct: 1870 AEITCKDNKDGTCTVSYLPTAPGDYSIIVRFDDKHIPGSPFTAKITGDDSMRTSQLNVGT 1929

Query: 426  SHGVVNKPAVFTVNTKDAGEGGLSLAIEGPSKAEISCTDNQ--DGTCSVSYLPVLPGDYS 599
            S  V  K     +   D  +  L+ +I  PS  E  C   +  +    +S+ P   G++ 
Sbjct: 1930 STDVSLK-----ITESDLSQ--LTASIRAPSGNEEPCLLKRLPNRHIGISFTPKEVGEHV 1982

Query: 600  ILVKYNEQHIPGSPFTARV----TGDDSM------RMSHLKVGSAADIPINISETDLSLL 749
            + V+ + +H+  SPF   V     GD S        +S  +    A+  ++        L
Sbjct: 1983 VSVRKSGKHVTNSPFKILVGPSEIGDASKVRVWGKGLSEGQTFQVAEFIVDTRNAGYGGL 2042

Query: 750  TATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNGQHVASSPIPVVISQSE 929
              ++  PS  +  C  + + +G   +++ P E G +++++K   +HV  SP  V ++   
Sbjct: 2043 GLSIEGPSKVDINC--EDMEDGTCKVTYCPTEPGTYIINIKFADKHVPGSPFTVKVTGE- 2099

Query: 930  IGDASRVRVSGRGLHEGHTFEPAEFIIDTR---DAGYGGLSLSIEGPSKVDINTEDLEDG 1100
                 R++ S     +  +        D        +  +  + E  ++    +      
Sbjct: 2100 ----GRMKESITRRRQAPSIATIGSTCDLNLKIPGNWFQMVSAQERLTRTFTRSSHTYTR 2155

Query: 1101 TCRVTYCPTEPGNYIINIKFADQ-HVPGSPFSVKVTGEGRVKE------SITRRQRAPSV 1259
            T R     T  G     ++  +   V G PF   V G+   +E      SITR+Q     
Sbjct: 2156 TERTEISKTRGGETKREVRVEESTQVGGDPFPA-VFGDFLGRERLGSFGSITRQQEG--- 2211

Query: 1260 ANVGSHCDLSLKIPEISIQDMTAQVTSPSGKSHEAEIVEGENHTYCIRFVPAEMGMHTVS 1439
                          E S QDMTAQVTSPSGK+  AEIVEGE+  Y +RFVP EMG HTV+
Sbjct: 2212 --------------EASSQDMTAQVTSPSGKTEAAEIVEGEDSAYSVRFVPQEMGPHTVT 2257

Query: 1440 VKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLERAEAGVPAEFSIWTREAGAGGLAI 1619
            VKY+GQHVPGSPFQFTVGPLGEGGAHKVRAGG GLER  AGVPAEFSIWTREAGAGGL+I
Sbjct: 2258 VKYRGQHVPGSPFQFTVGPLGEGGAHKVRAGGTGLERGVAGVPAEFSIWTREAGAGGLSI 2317

Query: 1620 AVEGPSKAEISFEDRKDGSCGVAYVVQEPGDYEVSVKFNEEHIPDSPFVVPVASPSGDAR 1799
            AVEGPSKAEI+FEDRKDGSCGV+YVVQEPGDYEVS+KFN+EHIPDSPFVVPVAS S DAR
Sbjct: 2318 AVEGPSKAEIAFEDRKDGSCGVSYVVQEPGDYEVSIKFNDEHIPDSPFVVPVASLSDDAR 2377

Query: 1800 RLTVSSLQESGLKVNQPASFAVSLNGAKGAIDAKVHSPSGALEECYVTEIDQDKYAVRFI 1979
            RLTV+SLQE+GLKVNQPASFAV LNGA+G IDA+VH+PSGA+EECYV+E+D DK+ +RFI
Sbjct: 2378 RLTVTSLQETGLKVNQPASFAVQLNGARGVIDARVHTPSGAVEECYVSELDSDKHTIRFI 2437

Query: 1980 PRENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPGLVSAYGAGLEGGVTGSPAEFIVN 2159
            P ENGV+ IDVKFNG HIPGSPFKIRVGE    GDPGLVSAYG GLEGG TG  +EFIVN
Sbjct: 2438 PHENGVHSIDVKFNGAHIPGSPFKIRVGEQSQAGDPGLVSAYGPGLEGGTTGVSSEFIVN 2497

Query: 2160 TSNAGAGALSVTIDGPSKVKMDCQECPEGYRVTYTPMAPGSYLISIKYGGPYHIGGSPFK 2339
            T NAG+GALSVTIDGPSKV++DC+ECPEG+ VTYTPMAPG+YLI+IKYGGP HI GSPFK
Sbjct: 2498 TLNAGSGALSVTIDGPSKVQLDCRECPEGHVVTYTPMAPGNYLIAIKYGGPQHIVGSPFK 2557

Query: 2340 ARVTGHRLVSNHSLHETSSVFVDSLTK--TXXXXXXXXXXXXXXXXSKVLAKGLGLSKAY 2513
            A+VTG RL   HSLHETS+V V+++TK  +                SKV+ +G GLS+A+
Sbjct: 2558 AKVTGPRLSGGHSLHETSTVLVETVTKSSSSRGSSYSSIPKFSSDASKVVTRGPGLSQAF 2617

Query: 2514 VGQKGSFTVDCSKAGNNMLLVGVHGPRTPCEEILVKHVGSRLYSVSYLLKDKGEYTLVVK 2693
            VGQK SFTVDCSKAG NM++VGVHGP+TPCEE+ VKHVG+R+Y+V+Y +K+KG+Y L+VK
Sbjct: 2618 VGQKNSFTVDCSKAGTNMMMVGVHGPKTPCEEVYVKHVGNRVYNVTYTVKEKGDYILIVK 2677

Query: 2694 WGDEHIPGSPYRVLVP 2741
            WGDE +PGSP++V VP
Sbjct: 2678 WGDESVPGSPFKVNVP 2693



 Score =  697 bits (1799), Expect = 0.0
 Identities = 406/887 (45%), Positives = 526/887 (59%), Gaps = 12/887 (1%)
 Frame = +3

Query: 114  APERPLVGVNGLDVTSLRPFDLVIPFTIKKGEITGEVRMPSGKVAQPAITDNKDGTVTVR 293
            A E P+V V  ++ + LRPF+LVIPFT++KGE+TGEVRMPSGK A+P ITDNKDGT+TVR
Sbjct: 1735 ATEEPVVPVESME-SMLRPFNLVIPFTVQKGELTGEVRMPSGKTARPNITDNKDGTITVR 1793

Query: 294  YAPSEAGLHEMDIRYDNMHIPGSPLQFYVDYVNCGHVTAYGPGLSHGVVNKPAVFTVNTK 473
            YAP+E GLH+M I+YD  HIPGSPLQFYVD +N  HV+AYGPGLSHG+VNKPA FT+ TK
Sbjct: 1794 YAPTEKGLHQMGIKYDGNHIPGSPLQFYVDAINSRHVSAYGPGLSHGMVNKPATFTIVTK 1853

Query: 474  DAGEGGLSLAIEGPSKAEISCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTAR 653
            DAGEGGLSLA+EGPSKAEI+C DN+DGTC+VSYLP  PGDYSI+V+++++HIPGSPFTA+
Sbjct: 1854 DAGEGGLSLAVEGPSKAEITCKDNKDGTCTVSYLPTAPGDYSIIVRFDDKHIPGSPFTAK 1913

Query: 654  VTGDDSMRMSHLKVGSAADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISF 833
            +TGDDSMR S L VG++ D+ + I+E+DLS LTA++  PSG EEPCLLKRL N H+GISF
Sbjct: 1914 ITGDDSMRTSQLNVGTSTDVSLKITESDLSQLTASIRAPSGNEEPCLLKRLPNRHIGISF 1973

Query: 834  VPKETGEHLVHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEGHTFEPAEFIID 1013
             PKE GEH+V V+K+G+HV +SP  +++  SEIGDAS+VRV G+GL EG TF+ AEFI+D
Sbjct: 1974 TPKEVGEHVVSVRKSGKHVTNSPFKILVGPSEIGDASKVRVWGKGLSEGQTFQVAEFIVD 2033

Query: 1014 TRDAGYGGLSLSIEGPSKVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFS 1193
            TR+AGYGGL LSIEGPSKVDIN ED+EDGTC+VTYCPTEPG YIINIKFAD+HVPGSPF+
Sbjct: 2034 TRNAGYGGLGLSIEGPSKVDINCEDMEDGTCKVTYCPTEPGTYIINIKFADKHVPGSPFT 2093

Query: 1194 VKVTGEGRVKESITRRQRAPSVANVGSHCDLSLKIPEISIQDMTAQVTSPSGKSHEAEIV 1373
            VKVTGEGR+KESITRR++APS+A +GS CDL+LKIP    Q ++AQ       +  +   
Sbjct: 2094 VKVTGEGRMKESITRRRQAPSIATIGSTCDLNLKIPGNWFQMVSAQERLTRTFTRSSHTY 2153

Query: 1374 EGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPG-LER 1550
                 T   +    E     V V+   Q V G PF    G        + R G  G + R
Sbjct: 2154 TRTERTEISKTRGGET-KREVRVEESTQ-VGGDPFPAVFGDF----LGRERLGSFGSITR 2207

Query: 1551 AEAGVPAEFSIWTREAGAGGLAIAVEGPS-KAEIS-FEDRKDGSCGVAYVVQEPGDYEVS 1724
             + G          EA +  +   V  PS K E +   + +D +  V +V QE G + V+
Sbjct: 2208 QQEG----------EASSQDMTAQVTSPSGKTEAAEIVEGEDSAYSVRFVPQEMGPHTVT 2257

Query: 1725 VKFNEEHIPDSPFVVPVAS-PSGDARRLTVSSLQESGLKVNQPASFAV-SLNGAKGAIDA 1898
            VK+  +H+P SPF   V     G A ++              PA F++ +     G +  
Sbjct: 2258 VKYRGQHVPGSPFQFTVGPLGEGGAHKVRAGGTGLERGVAGVPAEFSIWTREAGAGGLSI 2317

Query: 1899 KVHSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGHG 2078
             V  PS A  E    +       V ++ +E G Y + +KFN  HIP SPF + V      
Sbjct: 2318 AVEGPSKA--EIAFEDRKDGSCGVSYVVQEPGDYEVSIKFNDEHIPDSPFVVPVA--SLS 2373

Query: 2079 GDPGLVSAYGAGLEGGVTGSPAEFIVNTSNAGAGALSVTIDGPSKVKMDC---QECPEGY 2249
             D   ++       G     PA F V   N   G +   +  PS    +C   +   + +
Sbjct: 2374 DDARRLTVTSLQETGLKVNQPASFAVQL-NGARGVIDARVHTPSGAVEECYVSELDSDKH 2432

Query: 2250 RVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSVFVDSLTKTXX 2429
             + + P   G + I +K+ G  HI GSPFK RV       +  L                
Sbjct: 2433 TIRFIPHENGVHSIDVKFNGA-HIPGSPFKIRVGEQSQAGDPGL---------------- 2475

Query: 2430 XXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKAGNNMLLVGVHGP---RTP 2600
                            V A G GL     G    F V+   AG+  L V + GP   +  
Sbjct: 2476 ----------------VSAYGPGLEGGTTGVSSEFIVNTLNAGSGALSVTIDGPSKVQLD 2519

Query: 2601 CEEILVKHVGSRLYSVSYLLKDKGEYTLVVKW-GDEHIPGSPYRVLV 2738
            C E    HV      V+Y     G Y + +K+ G +HI GSP++  V
Sbjct: 2520 CRECPEGHV------VTYTPMAPGNYLIAIKYGGPQHIVGSPFKAKV 2560



 Score =  418 bits (1075), Expect = e-117
 Identities = 253/731 (34%), Positives = 384/731 (52%), Gaps = 28/731 (3%)
 Frame = +3

Query: 246  AQPAITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFYV-DYVNCGHVTAYGPG 422
            A+ +  DNKDG+ TV Y P   G ++++I +    IPGSP +  V D V+ G V   GPG
Sbjct: 1394 AKMSCKDNKDGSCTVEYIPFTPGDYDVNITFGGRPIPGSPFRVPVKDVVDPGKVKCSGPG 1453

Query: 423  LSHGV-VNKPAVFTVNTKDAGEGGLSLAIEGPSKAE--ISCTDNQDGTCSVSYLPVLPGD 593
            L  GV    P  FTV+   AG   L +A+  P+     +   DN DGT +V Y P   G 
Sbjct: 1454 LGAGVRARVPQTFTVDCSQAGRAPLQVAVLSPTGVAEPVEVRDNGDGTHTVHYTPATDGP 1513

Query: 594  YSILVKYNEQHIPGSPFTARV----------TGDDSMRMSHLKVGSAADIPINISETDLS 743
            Y++ VKY +Q +P SPF  +V               +  S +      +  I+  +    
Sbjct: 1514 YTVAVKYADQEVPRSPFKIKVLPAHDASKVRASGPGLNASGIPASLPVEFTIDARDAGEG 1573

Query: 744  LLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNGQHVASSPIPVVISQ 923
            LLT  ++ P G+ +   ++   +G   +S++P  +G + + +K  G  +  SP    I  
Sbjct: 1574 LLTVQILDPEGKPKKANIRDNGDGTYTVSYLPDMSGRYTITIKYGGDEIPYSPFR--IHA 1631

Query: 924  SEIGDASR----VRVSGRGLHE--GHTFEPAE---FIIDTRDAGYGGLSLSIEGP--SKV 1070
               GDAS+    V + G GL    G   +  E     +D + AG G ++ ++  P  +++
Sbjct: 1632 LPTGDASKCLVTVSIGGHGLGACLGPRIQIGEETVITVDAKAAGKGKVTCTVSTPDGAEL 1691

Query: 1071 DINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTGEGRVKESITRRQRA 1250
            D++  +  DGT  + Y   EPG Y+I I+F  +H+P SPF V  T E  V          
Sbjct: 1692 DVDVVENHDGTFDIYYTAPEPGKYVITIRFGGEHIPNSPFHVLATEEPVVPVESMESMLR 1751

Query: 1251 PSVANVGSHCDLSLKIP-EISIQDMTAQVTSPSGKSHEAEIVEGENHTYCIRFVPAEMGM 1427
            P           +L IP  +   ++T +V  PSGK+    I + ++ T  +R+ P E G+
Sbjct: 1752 P----------FNLVIPFTVQKGELTGEVRMPSGKTARPNITDNKDGTITVRYAPTEKGL 1801

Query: 1428 HTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLERAEAGVPAEFSIWTREAGAG 1607
            H + +KY G H+PGSP QF V  +    +  V A GPGL       PA F+I T++AG G
Sbjct: 1802 HQMGIKYDGNHIPGSPLQFYVDAIN---SRHVSAYGPGLSHGMVNKPATFTIVTKDAGEG 1858

Query: 1608 GLAIAVEGPSKAEISFEDRKDGSCGVAYVVQEPGDYEVSVKFNEEHIPDSPFVVPVASPS 1787
            GL++AVEGPSKAEI+ +D KDG+C V+Y+   PGDY + V+F+++HIP SPF   +   +
Sbjct: 1859 GLSLAVEGPSKAEITCKDNKDGTCTVSYLPTAPGDYSIIVRFDDKHIPGSPFTAKI---T 1915

Query: 1788 GDARRLTVSSLQESGLKVNQPASFAVSLNGAK-GAIDAKVHSPSGALEECYVTEIDQDKY 1964
            GD       S++ S L V      ++ +  +    + A + +PSG  E C +  +     
Sbjct: 1916 GD------DSMRTSQLNVGTSTDVSLKITESDLSQLTASIRAPSGNEEPCLLKRLPNRHI 1969

Query: 1965 AVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPGLVSAYGAGLEGGVTGSPA 2144
             + F P+E G +++ V+ +G H+  SPFKI VG P   GD   V  +G GL  G T   A
Sbjct: 1970 GISFTPKEVGEHVVSVRKSGKHVTNSPFKILVG-PSEIGDASKVRVWGKGLSEGQTFQVA 2028

Query: 2145 EFIVNTSNAGAGALSVTIDGPSKVKMDCQECPEGY-RVTYTPMAPGSYLISIKYGGPYHI 2321
            EFIV+T NAG G L ++I+GPSKV ++C++  +G  +VTY P  PG+Y+I+IK+    H+
Sbjct: 2029 EFIVDTRNAGYGGLGLSIEGPSKVDINCEDMEDGTCKVTYCPTEPGTYIINIKFADK-HV 2087

Query: 2322 GGSPFKARVTG 2354
             GSPF  +VTG
Sbjct: 2088 PGSPFTVKVTG 2098



 Score =  390 bits (1002), Expect = e-108
 Identities = 281/896 (31%), Positives = 420/896 (46%), Gaps = 31/896 (3%)
 Frame = +3

Query: 144  GLDVTSLRPFDLVIPFTIK-----KGEITGEVRMPSGKVAQPAITDNKDGTVTVRYAPSE 308
            GL+ + + P  L + FTI      +G +T ++  P GK  +  I DN DGT TV Y P  
Sbjct: 1549 GLNASGI-PASLPVEFTIDARDAGEGLLTVQILDPEGKPKKANIRDNGDGTYTVSYLPDM 1607

Query: 309  AGLHEMDIRYDNMHIPGSPLQFYV----DYVNCGHVTAYGPGLSHGV---------VNKP 449
            +G + + I+Y    IP SP + +     D   C    + G    HG+         + + 
Sbjct: 1608 SGRYTITIKYGGDEIPYSPFRIHALPTGDASKCLVTVSIG---GHGLGACLGPRIQIGEE 1664

Query: 450  AVFTVNTKDAGEGGLSLAIEGPSKAE--ISCTDNQDGTCSVSYLPVLPGDYSILVKYNEQ 623
             V TV+ K AG+G ++  +  P  AE  +   +N DGT  + Y    PG Y I +++  +
Sbjct: 1665 TVITVDAKAAGKGKVTCTVSTPDGAELDVDVVENHDGTFDIYYTAPEPGKYVITIRFGGE 1724

Query: 624  HIPGSPFTARVTGDDSM---RMSHLKVGSAADIPINISETDLSLLTATVVPPSGREEPCL 794
            HIP SPF    T +  +    M  +       IP  + + +   LT  V  PSG+     
Sbjct: 1725 HIPNSPFHVLATEEPVVPVESMESMLRPFNLVIPFTVQKGE---LTGEVRMPSGKTARPN 1781

Query: 795  LKRLRNGHVGISFVPKETGEHLVHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLH 974
            +   ++G + + + P E G H + +K +G H+  SP+   +   +  ++  V   G GL 
Sbjct: 1782 ITDNKDGTITVRYAPTEKGLHQMGIKYDGNHIPGSPLQFYV---DAINSRHVSAYGPGLS 1838

Query: 975  EGHTFEPAEFIIDTRDAGYGGLSLSIEGPSKVDINTEDLEDGTCRVTYCPTEPGNYIINI 1154
             G   +PA F I T+DAG GGLSL++EGPSK +I  +D +DGTC V+Y PT PG+Y I +
Sbjct: 1839 HGMVNKPATFTIVTKDAGEGGLSLAVEGPSKAEITCKDNKDGTCTVSYLPTAPGDYSIIV 1898

Query: 1155 KFADQHVPGSPFSVKVTGEGRVKESITRRQRAPSVANVGSHCDLSLKIPEISIQDMTAQV 1334
            +F D+H+PGSPF+ K+TG+  ++          S  NVG+  D+SLKI E  +  +TA +
Sbjct: 1899 RFDDKHIPGSPFTAKITGDDSMR---------TSQLNVGTSTDVSLKITESDLSQLTASI 1949

Query: 1335 TSPSGKSHEAEIVEGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGA 1514
             +PSG      +    N    I F P E+G H VSV+  G+HV  SPF+  VGP   G A
Sbjct: 1950 RAPSGNEEPCLLKRLPNRHIGISFTPKEVGEHVVSVRKSGKHVTNSPFKILVGPSEIGDA 2009

Query: 1515 HKVRAGGPGLERAEAGVPAEFSIWTREAGAGGLAIAVEGPSKAEISFEDRKDGSCGVAYV 1694
             KVR  G GL   +    AEF + TR AG GGL +++EGPSK +I+ ED +DG+C V Y 
Sbjct: 2010 SKVRVWGKGLSEGQTFQVAEFIVDTRNAGYGGLGLSIEGPSKVDINCEDMEDGTCKVTYC 2069

Query: 1695 VQEPGDYEVSVKFNEEHIPDSPFVVPVASPSGDARRLTVSSLQESGLKVNQPASFAVSLN 1874
              EPG Y +++KF ++H+P SPF V V   +G+ R      ++ES  +  Q  S A    
Sbjct: 2070 PTEPGTYIINIKFADKHVPGSPFTVKV---TGEGR------MKESITRRRQAPSIAT--- 2117

Query: 1875 GAKGAIDAKVHSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFK- 2051
                  D  +  P       +   +   +   R   R +  Y    +   +   G   K 
Sbjct: 2118 -IGSTCDLNLKIPGN-----WFQMVSAQERLTRTFTRSSHTYTRTERTEISKTRGGETKR 2171

Query: 2052 -IRVGEPGH-GGDPGLVSAYGAGLEGGVTGSPAEFI-VNTSNAGAGALSVTIDGPSKVKM 2222
             +RV E    GGDP   + +G  L     GS           A +  ++  +  PS  K 
Sbjct: 2172 EVRVEESTQVGGDP-FPAVFGDFLGRERLGSFGSITRQQEGEASSQDMTAQVTSPSG-KT 2229

Query: 2223 DCQECPEG----YRVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHET 2390
            +  E  EG    Y V + P   G + +++KY G  H+ GSPF+  V              
Sbjct: 2230 EAAEIVEGEDSAYSVRFVPQEMGPHTVTVKYRG-QHVPGSPFQFTV-------------- 2274

Query: 2391 SSVFVDSLTKTXXXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKAGNNML 2570
                                        KV A G GL +   G    F++   +AG   L
Sbjct: 2275 -------------------GPLGEGGAHKVRAGGTGLERGVAGVPAEFSIWTREAGAGGL 2315

Query: 2571 LVGVHGPRTPCEEILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLV 2738
             + V GP     EI  +        VSY++++ G+Y + +K+ DEHIP SP+ V V
Sbjct: 2316 SIAVEGPSK--AEIAFEDRKDGSCGVSYVVQEPGDYEVSIKFNDEHIPDSPFVVPV 2369



 Score =  358 bits (919), Expect = 1e-98
 Identities = 278/885 (31%), Positives = 414/885 (46%), Gaps = 40/885 (4%)
 Frame = +3

Query: 204  GEITGEVRMPSGK--VAQPAITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFY 377
            G++   +  P G+    + A+ D  D T    Y P   G H + + +    I  SP   +
Sbjct: 409  GDVAVVIVDPQGRRDTVEVALEDKGDSTFRCTYRPVMEGPHTVHVAFAGAPITRSPFPVH 468

Query: 378  V-DYVNCGHVTAYGPGLS-HGV-VNKPAVFTVNTKDAGEGGLSLAIEGPSKAE--ISCTD 542
            V +  N     A G GL   GV V + A F V TK AG G L + ++GP   E  +   D
Sbjct: 469  VAEACNPNACRASGRGLQPKGVRVKEVADFKVFTKGAGSGELKVTVKGPKGTEEPVKVRD 528

Query: 543  NQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARVTGDDSMR--------MSHLKVG 698
              DG     Y PV+PG Y + + +    IP SPF  +V+ +  M+        +   +VG
Sbjct: 529  AGDGVFECEYYPVVPGKYVVTITWGGYAIPRSPFEVQVSPEAGMQKVRAWGPGLETGQVG 588

Query: 699  SAADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKN 878
             +AD  +    T++  L  ++  PS  +  C  K   +G   + + P E GE+ VHV  +
Sbjct: 589  KSADFVVEAIGTEVGTLGFSIEGPSQAKIECDDK--GDGSCDVRYWPTEPGEYAVHVICD 646

Query: 879  GQHVASSPIPVVISQSEIG-DASRVRVSGRGLHEGHTF--EPAEFIIDTRDAGYGGLSLS 1049
             + +  SP    I  +       +V+  G GL        +PAEF ID R AG G L L 
Sbjct: 647  DEDIRDSPFIAHIQPAPPDCFPDKVKAFGPGLEPTGCIVDKPAEFTIDARAAGKGDLKLY 706

Query: 1050 IEGPS--KVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTGEGRVK 1223
             +      +DI      DGT R +Y PT+P  + I I +   +VP SPF V V GEG   
Sbjct: 707  AQDADGCPIDIKVIPNGDGTFRCSYVPTKPIKHTIIISWGGVNVPKSPFRVNV-GEGSHP 765

Query: 1224 ESITRRQRAPSVANVGSHCD----LSLKIPEISIQDMT------AQVTSPSGKSHEAEIV 1373
            E +  +   P V   G   +     ++   E    D++        V  P+    + +I+
Sbjct: 766  ERV--KVYGPGVEKTGLKANEPTYFTVDCSEAGQGDVSIGIKCAPGVVGPAEADIDFDII 823

Query: 1374 EGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLER- 1550
            + +N T+ +++ P   G +T+ V +  Q +P SPF   V P  +  A KV+A GPGL R 
Sbjct: 824  KNDNDTFTVKYTPPGAGRYTIMVLFANQEIPASPFHIKVDPSHD--ASKVKAEGPGLNRT 881

Query: 1551 -AEAGVPAEFSIWTREAGAGGLAIAVEGPSKAEI--SFE--DRKDGSCGVAYVVQEPGDY 1715
              E G P  F++ T+ AG   L +   G +K E    FE  D  D S  V Y   + G+ 
Sbjct: 882  GVEVGKPTHFTVLTKGAGKAKLDVHFAGAAKGEAVRDFEIIDNHDYSYTVKYTAVQQGNM 941

Query: 1716 EVSVKFNEEHIPDSPFVVPVASPSGDARRLTVSSLQESGLKVNQPASFAVSLNGA--KGA 1889
             V+V +  + +P SPFVV VA P  D  ++ V  L  S + V Q  +F+V+  GA  +G 
Sbjct: 942  AVTVTYGGDPVPKSPFVVNVAPPL-DLSKVKVQGL-NSKVAVGQEQAFSVNTRGAGGQGQ 999

Query: 1890 IDAKVHSPSGALEECYVTE-IDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGE 2066
            +D ++ SPS     C +      D  AVR++P E G Y +D+ ++G  +PGSPF +    
Sbjct: 1000 LDVRMTSPSRRPIPCKLEPGGGADAQAVRYMPPEEGPYKVDITYDGHPVPGSPFAVEGVL 1059

Query: 2067 PGHGGDPGLVSAYGAGLEGGVTGSPAEFIVNTSNAGAGALSVTIDGPSKVKMDCQECPEG 2246
            P    DP  V AYG GL+GG+ G+PA F ++T  AG G L +T++GP + K++CQ+  +G
Sbjct: 1060 P---PDPSKVCAYGPGLKGGLVGTPAPFSIDTKGAGTGGLGLTVEGPCEAKIECQDNGDG 1116

Query: 2247 -YRVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSVFVDSLTKT 2423
               V+Y P  PG Y I+I +    HI GSPFKA +                VF       
Sbjct: 1117 SCAVSYLPTEPGEYTINILF-AEAHIPGSPFKATI--------------RPVF------- 1154

Query: 2424 XXXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKAGNNMLLVGVHGPRTPC 2603
                            SKV A G GL +   G+  +FTVDCS+AG   L + +       
Sbjct: 1155 --------------DPSKVRASGPGLERGKAGEAATFTVDCSEAGEAELTIEILSDAGVK 1200

Query: 2604 EEILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLV 2738
             E+L+ +     Y ++Y     G YT+ +K+G   +P  P RV V
Sbjct: 1201 AEVLIHNNADGTYHITYSPAFPGTYTITIKYGGHPVPKFPTRVHV 1245



 Score =  325 bits (834), Expect = 7e-89
 Identities = 250/888 (28%), Positives = 402/888 (45%), Gaps = 42/888 (4%)
 Frame = +3

Query: 201  KGEITGEVRMPSGKVAQPAITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFYV 380
            + E+T E+   +G  A+  I +N DGT  + Y+P+  G + + I+Y    +P  P + +V
Sbjct: 1186 EAELTIEILSDAGVKAEVLIHNNADGTYHITYSPAFPGTYTITIKYGGHPVPKFPTRVHV 1245

Query: 381  D-YVNCGHVTAYGPGLS-HGVVNKPAV-FTVNTKD---AGEGGLSLAIEGPS--KAEISC 536
               V+   V   GPG+  HGV+ +    FTV+ +     G   ++  +  PS  K +   
Sbjct: 1246 QPAVDTSGVKVSGPGVEPHGVLREVTTEFTVDARSLTATGGNHVTARVLNPSGAKTDTYV 1305

Query: 537  TDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARVT-GDDSMRMSHL-------K 692
            TDN DGT  V Y     G + + V Y++  +P SPF   VT G D  R+           
Sbjct: 1306 TDNGDGTYRVQYTAYEEGVHLVEVLYDDVAVPKSPFRVGVTEGCDPTRVRAFGPGLEGGL 1365

Query: 693  VGSAADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVK 872
            V  A    +         L   +  PS  +  C  K  ++G   + ++P   G++ V++ 
Sbjct: 1366 VNKANRFTVETRGAGTGGLGLAIEGPSEAKMSC--KDNKDGSCTVEYIPFTPGDYDVNIT 1423

Query: 873  KNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEG-HTFEPAEFIIDTRDAGYGGLSLS 1049
              G+ +  SP  V +   ++ D  +V+ SG GL  G     P  F +D   AG   L ++
Sbjct: 1424 FGGRPIPGSPFRVPV--KDVVDPGKVKCSGPGLGAGVRARVPQTFTVDCSQAGRAPLQVA 1481

Query: 1050 IEGPSKV--DINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTGEGRVK 1223
            +  P+ V   +   D  DGT  V Y P   G Y + +K+ADQ VP SPF +KV       
Sbjct: 1482 VLSPTGVAEPVEVRDNGDGTHTVHYTPATDGPYTVAVKYADQEVPRSPFKIKVL---PAH 1538

Query: 1224 ESITRRQRAPSVANVGSHCDLSLKIPEISIQD-----MTAQVTSPSGKSHEAEIVEGENH 1388
            ++   R   P +   G    L ++   I  +D     +T Q+  P GK  +A I +  + 
Sbjct: 1539 DASKVRASGPGLNASGIPASLPVEF-TIDARDAGEGLLTVQILDPEGKPKKANIRDNGDG 1597

Query: 1389 TYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGG--AHKVRAGGPGL-----E 1547
            TY + ++P   G +T+++KY G  +P SPF+    P G+       V  GG GL      
Sbjct: 1598 TYTVSYLPDMSGRYTITIKYGGDEIPYSPFRIHALPTGDASKCLVTVSIGGHGLGACLGP 1657

Query: 1548 RAEAGVPAEFSIWTREAGAGGLAIAVEGPSKAEISFE--DRKDGSCGVAYVVQEPGDYEV 1721
            R + G     ++  + AG G +   V  P  AE+  +  +  DG+  + Y   EPG Y +
Sbjct: 1658 RIQIGEETVITVDAKAAGKGKVTCTVSTPDGAELDVDVVENHDGTFDIYYTAPEPGKYVI 1717

Query: 1722 SVKFNEEHIPDSPF--------VVPVASPSGDARRLTVSSLQESGLKVNQPASFAVSLNG 1877
            +++F  EHIP+SPF        VVPV S              ES L+   P +  +    
Sbjct: 1718 TIRFGGEHIPNSPFHVLATEEPVVPVES-------------MESMLR---PFNLVIPFTV 1761

Query: 1878 AKGAIDAKVHSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIR 2057
             KG +  +V  PSG      +T+       VR+ P E G++ + +K++G HIPGSP +  
Sbjct: 1762 QKGELTGEVRMPSGKTARPNITDNKDGTITVRYAPTEKGLHQMGIKYDGNHIPGSPLQFY 1821

Query: 2058 VGEPGHGGDPGLVSAYGAGLEGGVTGSPAEFIVNTSNAGAGALSVTIDGPSKVKMDCQEC 2237
            V       +   VSAYG GL  G+   PA F + T +AG G LS+ ++GPSK ++ C++ 
Sbjct: 1822 V----DAINSRHVSAYGPGLSHGMVNKPATFTIVTKDAGEGGLSLAVEGPSKAEITCKDN 1877

Query: 2238 PEG-YRVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSVFVDSL 2414
             +G   V+Y P APG Y I +++    HI GSPF A++TG                 D  
Sbjct: 1878 KDGTCTVSYLPTAPGDYSIIVRFDDK-HIPGSPFTAKITG-----------------DDS 1919

Query: 2415 TKTXXXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKAGNNMLLVGVHGPR 2594
             +T                          S+  VG     ++  +++  + L   +  P 
Sbjct: 1920 MRT--------------------------SQLNVGTSTDVSLKITESDLSQLTASIRAPS 1953

Query: 2595 TPCEEILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLV 2738
               E  L+K + +R   +S+  K+ GE+ + V+   +H+  SP+++LV
Sbjct: 1954 GNEEPCLLKRLPNRHIGISFTPKEVGEHVVSVRKSGKHVTNSPFKILV 2001



 Score =  306 bits (783), Expect = 6e-83
 Identities = 267/894 (29%), Positives = 406/894 (45%), Gaps = 48/894 (5%)
 Frame = +3

Query: 201  KGEITGEVRMPSGKVAQPAITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFYV 380
            KG++    +   G      +  N DGT    Y P++   H + I +  +++P SP +  V
Sbjct: 700  KGDLKLYAQDADGCPIDIKVIPNGDGTFRCSYVPTKPIKHTIIISWGGVNVPKSPFRVNV 759

Query: 381  -DYVNCGHVTAYGPGLSHG--VVNKPAVFTVNTKDAGEGGLSLAIE------GPSKAEI- 530
             +  +   V  YGPG+       N+P  FTV+  +AG+G +S+ I+      GP++A+I 
Sbjct: 760  GEGSHPERVKVYGPGVEKTGLKANEPTYFTVDCSEAGQGDVSIGIKCAPGVVGPAEADID 819

Query: 531  -SCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARVTGDDSMRMSHLKVGSAA 707
                 N + T +V Y P   G Y+I+V +  Q IP SPF  +V  D S   S +K   A 
Sbjct: 820  FDIIKNDNDTFTVKYTPPGAGRYTIMVLFANQEIPASPFHIKV--DPSHDASKVK---AE 874

Query: 708  DIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVG-----------------ISFV 836
               +N +  ++   T   V   G  +  L         G                 + + 
Sbjct: 875  GPGLNRTGVEVGKPTHFTVLTKGAGKAKLDVHFAGAAKGEAVRDFEIIDNHDYSYTVKYT 934

Query: 837  PKETGEHLVHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEGHTFEPAEFIIDT 1016
              + G   V V   G  V  SP   V++ +   D S+V+V G         E A F ++T
Sbjct: 935  AVQQGNMAVTVTYGGDPVPKSPF--VVNVAPPLDLSKVKVQGLNSKVAVGQEQA-FSVNT 991

Query: 1017 RDA-GYGGLSLSIEGPSKVDINTEDLEDG----TCRVTYCPTEPGNYIINIKFADQHVPG 1181
            R A G G L + +  PS+  I  + LE G       V Y P E G Y ++I +    VPG
Sbjct: 992  RGAGGQGQLDVRMTSPSRRPIPCK-LEPGGGADAQAVRYMPPEEGPYKVDITYDGHPVPG 1050

Query: 1182 SPFSVKVTGEGRVKESITR-RQRAPSVAN--VGSHCDLSLKIPEISIQDMTAQVTSPSGK 1352
            SPF+V    EG +    ++     P +    VG+    S+         +   V  P   
Sbjct: 1051 SPFAV----EGVLPPDPSKVCAYGPGLKGGLVGTPAPFSIDTKGAGTGGLGLTVEGPCEA 1106

Query: 1353 SHEAEIVEGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAG 1532
              E +  +  + +  + ++P E G +T+++ +   H+PGSPF+ T+ P+ +    KVRA 
Sbjct: 1107 KIECQ--DNGDGSCAVSYLPTEPGEYTINILFAEAHIPGSPFKATIRPVFD--PSKVRAS 1162

Query: 1533 GPGLERAEAGVPAEFSIWTREAGAGGLAIAV--EGPSKAEISFEDRKDGSCGVAYVVQEP 1706
            GPGLER +AG  A F++   EAG   L I +  +   KAE+   +  DG+  + Y    P
Sbjct: 1163 GPGLERGKAGEAATFTVDCSEAGEAELTIEILSDAGVKAEVLIHNNADGTYHITYSPAFP 1222

Query: 1707 GDYEVSVKFNEEHIPDSPFVVPVASPSGDARRLTVS--SLQESGLKVNQPASFAV---SL 1871
            G Y +++K+    +P  P  V V  P+ D   + VS   ++  G+       F V   SL
Sbjct: 1223 GTYTITIKYGGHPVPKFPTRVHV-QPAVDTSGVKVSGPGVEPHGVLREVTTEFTVDARSL 1281

Query: 1872 NGAKG-AIDAKVHSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPF 2048
                G  + A+V +PSGA  + YVT+     Y V++   E GV+L++V ++   +P SPF
Sbjct: 1282 TATGGNHVTARVLNPSGAKTDTYVTDNGDGTYRVQYTAYEEGVHLVEVLYDDVAVPKSPF 1341

Query: 2049 KIRVGEPGHGGDPGLVSAYGAGLEGGVTGSPAEFIVNTSNAGAGALSVTIDGPSKVKMDC 2228
            ++ V E   G DP  V A+G GLEGG+      F V T  AG G L + I+GPS+ KM C
Sbjct: 1342 RVGVTE---GCDPTRVRAFGPGLEGGLVNKANRFTVETRGAGTGGLGLAIEGPSEAKMSC 1398

Query: 2229 QECPEG-YRVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSVFV 2405
            ++  +G   V Y P  PG Y ++I +GG   I GSPF+  V                  V
Sbjct: 1399 KDNKDGSCTVEYIPFTPGDYDVNITFGG-RPIPGSPFRVPVKD---------------VV 1442

Query: 2406 DSLTKTXXXXXXXXXXXXXXXXSKVLAKGLGLS---KAYVGQKGSFTVDCSKAGNNMLLV 2576
            D                      KV   G GL    +A V Q  +FTVDCS+AG   L V
Sbjct: 1443 D--------------------PGKVKCSGPGLGAGVRARVPQ--TFTVDCSQAGRAPLQV 1480

Query: 2577 GVHGPRTPCEEILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLV 2738
             V  P    E + V+  G   ++V Y     G YT+ VK+ D+ +P SP+++ V
Sbjct: 1481 AVLSPTGVAEPVEVRDNGDGTHTVHYTPATDGPYTVAVKYADQEVPRSPFKIKV 1534



 Score =  298 bits (763), Expect = 1e-80
 Identities = 247/895 (27%), Positives = 384/895 (42%), Gaps = 50/895 (5%)
 Frame = +3

Query: 204  GEITGEVRMPSGKVAQPAITDN--KDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFY 377
            GE+   +  P G   +  +  N  KD T  V Y P  AGLH++ + +   +I  SP +  
Sbjct: 309  GEVLVYIEDPEGHTEEAKVVPNNDKDRTYAVSYVPKVAGLHKVTVLFAGQNIERSPFEVN 368

Query: 378  VDYV--NCGHVTAYGPGLS--HGVVNKPAVFTVNTKDAGEGGLSLAIEGP----SKAEIS 533
            V     +   V+A GPGL     V NKP  F + T  AG G +++ I  P       E++
Sbjct: 369  VGMALGDANKVSARGPGLEPVGNVANKPTYFDIYTAGAGTGDVAVVIVDPQGRRDTVEVA 428

Query: 534  CTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARV----------TGDDSMRMS 683
              D  D T   +Y PV+ G +++ V +    I  SPF   V               ++  
Sbjct: 429  LEDKGDSTFRCTYRPVMEGPHTVHVAFAGAPITRSPFPVHVAEACNPNACRASGRGLQPK 488

Query: 684  HLKVGSAADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLV 863
             ++V   AD  +         L  TV  P G EEP  ++   +G     + P   G+++V
Sbjct: 489  GVRVKEVADFKVFTKGAGSGELKVTVKGPKGTEEPVKVRDAGDGVFECEYYPVVPGKYVV 548

Query: 864  HVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEGHTFEPAEFIIDTRDAGYGGLS 1043
             +   G  +  SP  V +S        +VR  G GL  G   + A+F+++      G L 
Sbjct: 549  TITWGGYAIPRSPFEVQVSPE--AGMQKVRAWGPGLETGQVGKSADFVVEAIGTEVGTLG 606

Query: 1044 LSIEGPSKVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTGEGRVK 1223
             SIEGPS+  I  +D  DG+C V Y PTEPG Y +++   D+ +  SPF   +  +    
Sbjct: 607  FSIEGPSQAKIECDDKGDGSCDVRYWPTEPGEYAVHVICDDEDIRDSPFIAHI--QPAPP 664

Query: 1224 ESITRRQRA------PSVANVGSHCDLSLKIPEISIQDMTAQVTSPSGKSHEAEIVEGEN 1385
            +    + +A      P+   V    + ++        D+        G   + +++   +
Sbjct: 665  DCFPDKVKAFGPGLEPTGCIVDKPAEFTIDARAAGKGDLKLYAQDADGCPIDIKVIPNGD 724

Query: 1386 HTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAH--KVRAGGPGLERA-- 1553
             T+   +VP +   HT+ + + G +VP SPF+  VG     G+H  +V+  GPG+E+   
Sbjct: 725  GTFRCSYVPTKPIKHTIIISWGGVNVPKSPFRVNVGE----GSHPERVKVYGPGVEKTGL 780

Query: 1554 EAGVPAEFSIWTREAGAGGLAIAVE------GPSKAEISFEDRK--DGSCGVAYVVQEPG 1709
            +A  P  F++   EAG G ++I ++      GP++A+I F+  K  + +  V Y     G
Sbjct: 781  KANEPTYFTVDCSEAGQGDVSIGIKCAPGVVGPAEADIDFDIIKNDNDTFTVKYTPPGAG 840

Query: 1710 DYEVSVKFNEEHIPDSPFVVPVASPSGDARRLTVS--SLQESGLKVNQPASFAVSLNGAK 1883
             Y + V F  + IP SPF + V  PS DA ++      L  +G++V +P  F V   GA 
Sbjct: 841  RYTIMVLFANQEIPASPFHIKV-DPSHDASKVKAEGPGLNRTGVEVGKPTHFTVLTKGA- 898

Query: 1884 GAIDAKVH----SPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFK 2051
            G     VH    +   A+ +  + +     Y V++   + G   + V + G  +P SPF 
Sbjct: 899  GKAKLDVHFAGAAKGEAVRDFEIIDNHDYSYTVKYTAVQQGNMAVTVTYGGDPVPKSPFV 958

Query: 2052 IRVGEPGHGGDPGLVSAYGAGLEGGVTGSPAEFIVNTSNAGA-GALSVTIDGPSKVKMDC 2228
            + V  P    D   V   G   +  V G    F VNT  AG  G L V +  PS+  + C
Sbjct: 959  VNVAPP---LDLSKVKVQGLNSKVAV-GQEQAFSVNTRGAGGQGQLDVRMTSPSRRPIPC 1014

Query: 2229 QECPEG----YRVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSS 2396
            +  P G      V Y P   G Y + I Y G + + GSPF                    
Sbjct: 1015 KLEPGGGADAQAVRYMPPEEGPYKVDITYDG-HPVPGSPFAVE----------------- 1056

Query: 2397 VFVDSLTKTXXXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKAGNNMLLV 2576
                                     SKV A G GL    VG    F++D   AG   L +
Sbjct: 1057 ------------------GVLPPDPSKVCAYGPGLKGGLVGTPAPFSIDTKGAGTGGLGL 1098

Query: 2577 GVHGPRTPCE-EILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLV 2738
             V G   PCE +I  +  G    +VSYL  + GEYT+ + + + HIPGSP++  +
Sbjct: 1099 TVEG---PCEAKIECQDNGDGSCAVSYLPTEPGEYTINILFAEAHIPGSPFKATI 1150



 Score =  274 bits (700), Expect = 2e-73
 Identities = 243/873 (27%), Positives = 374/873 (42%), Gaps = 40/873 (4%)
 Frame = +3

Query: 264  DNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFYVDYV--NC--GHVTAYGPGLSH 431
            D  DG+  VRY P+E G + + +  D+  I  SP   ++     +C    V A+GPGL  
Sbjct: 621  DKGDGSCDVRYWPTEPGEYAVHVICDDEDIRDSPFIAHIQPAPPDCFPDKVKAFGPGLEP 680

Query: 432  G--VVNKPAVFTVNTKDAGEGGLSLAIEGPSKA--EISCTDNQDGTCSVSYLPVLPGDYS 599
               +V+KPA FT++ + AG+G L L  +       +I    N DGT   SY+P  P  ++
Sbjct: 681  TGCIVDKPAEFTIDARAAGKGDLKLYAQDADGCPIDIKVIPNGDGTFRCSYVPTKPIKHT 740

Query: 600  ILVKYNEQHIPGSPFTARVTGDDS-----------MRMSHLKVGSAADIPINISET---D 737
            I++ +   ++P SPF   V G+ S           +  + LK        ++ SE    D
Sbjct: 741  IIISWGGVNVPKSPFRVNV-GEGSHPERVKVYGPGVEKTGLKANEPTYFTVDCSEAGQGD 799

Query: 738  LSL---LTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNGQHVASSPIP 908
            +S+       VV P+  +    + +  N    + + P   G + + V    Q + +SP  
Sbjct: 800  VSIGIKCAPGVVGPAEADIDFDIIKNDNDTFTVKYTPPGAGRYTIMVLFANQEIPASPFH 859

Query: 909  VVISQSEIGDASRVRVSGRGLHEG--HTFEPAEFIIDTRDAGYGGLSLSIEGPSKV---- 1070
            + +  S   DAS+V+  G GL+       +P  F + T+ AG   L +   G +K     
Sbjct: 860  IKVDPSH--DASKVKAEGPGLNRTGVEVGKPTHFTVLTKGAGKAKLDVHFAGAAKGEAVR 917

Query: 1071 DINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTGEGRVKESITRRQRA 1250
            D    D  D +  V Y   + GN  + + +    VP SPF V V     +  S  + Q  
Sbjct: 918  DFEIIDNHDYSYTVKYTAVQQGNMAVTVTYGGDPVPKSPFVVNVAPP--LDLSKVKVQGL 975

Query: 1251 PSVANVGSHCDLSLKIPEISIQ-DMTAQVTSPSGKSHEAEIVEGEN-HTYCIRFVPAEMG 1424
             S   VG     S+       Q  +  ++TSPS +    ++  G       +R++P E G
Sbjct: 976  NSKVAVGQEQAFSVNTRGAGGQGQLDVRMTSPSRRPIPCKLEPGGGADAQAVRYMPPEEG 1035

Query: 1425 MHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLERAEAGVPAEFSIWTREAGA 1604
             + V + Y G  VPGSPF   V  +      KV A GPGL+    G PA FSI T+ AG 
Sbjct: 1036 PYKVDITYDGHPVPGSPF--AVEGVLPPDPSKVCAYGPGLKGGLVGTPAPFSIDTKGAGT 1093

Query: 1605 GGLAIAVEGPSKAEISFEDRKDGSCGVAYVVQEPGDYEVSVKFNEEHIPDSPFVVPVASP 1784
            GGL + VEGP +A+I  +D  DGSC V+Y+  EPG+Y +++ F E HIP SPF   +  P
Sbjct: 1094 GGLGLTVEGPCEAKIECQDNGDGSCAVSYLPTEPGEYTINILFAEAHIPGSPFKATI-RP 1152

Query: 1785 SGDARRLTVSSLQESGLKVNQPASFAVSLNGA-KGAIDAKVHSPSGALEECYVTEIDQDK 1961
              D  ++  S       K  + A+F V  + A +  +  ++ S +G   E  +       
Sbjct: 1153 VFDPSKVRASGPGLERGKAGEAATFTVDCSEAGEAELTIEILSDAGVKAEVLIHNNADGT 1212

Query: 1962 YAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPGLVSAYGAGLEGGVTGSP 2141
            Y + + P   G Y I +K+ G  +P  P ++ V +P        VS  G    G +    
Sbjct: 1213 YHITYSPAFPGTYTITIKYGGHPVPKFPTRVHV-QPAVDTSGVKVSGPGVEPHGVLREVT 1271

Query: 2142 AEFIVNTSN---AGAGALSVTIDGPSKVKMDCQECPEG---YRVTYTPMAPGSYLISIKY 2303
             EF V+  +    G   ++  +  PS  K D      G   YRV YT    G +L+ + Y
Sbjct: 1272 TEFTVDARSLTATGGNHVTARVLNPSGAKTDTYVTDNGDGTYRVQYTAYEEGVHLVEVLY 1331

Query: 2304 GGPYHIGGSPFKARVTGHRLVSNHSLHETSSVFVDSLTKTXXXXXXXXXXXXXXXXSKVL 2483
                 +  SPF+  VT                                        ++V 
Sbjct: 1332 -DDVAVPKSPFRVGVT-----------------------------------EGCDPTRVR 1355

Query: 2484 AKGLGLSKAYVGQKGSFTVDCSKAGNNMLLVGVHGPRTPCEEILVKHVGSRLYSVSYLLK 2663
            A G GL    V +   FTV+   AG   L + + GP            GS   +V Y+  
Sbjct: 1356 AFGPGLEGGLVNKANRFTVETRGAGTGGLGLAIEGPSEAKMSCKDNKDGS--CTVEYIPF 1413

Query: 2664 DKGEYTLVVKWGDEHIPGSPYRVLVP*ALCPGQ 2762
              G+Y + + +G   IPGSP+RV V   + PG+
Sbjct: 1414 TPGDYDVNITFGGRPIPGSPFRVPVKDVVDPGK 1446



 Score =  273 bits (697), Expect = 5e-73
 Identities = 172/478 (35%), Positives = 241/478 (50%), Gaps = 50/478 (10%)
 Frame = +3

Query: 207  EITGEVRMPSGKVAQPAITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFYVDY 386
            ++T +V  PSGK     I + +D   +VR+ P E G H + ++Y   H+PGSP QF V  
Sbjct: 2217 DMTAQVTSPSGKTEAAEIVEGEDSAYSVRFVPQEMGPHTVTVKYRGQHVPGSPFQFTVGP 2276

Query: 387  VNCG---HVTAYGPGLSHGVVNKPAVFTVNTKDAGEGGLSLAIEGPSKAEISCTDNQDGT 557
            +  G    V A G GL  GV   PA F++ T++AG GGLS+A+EGPSKAEI+  D +DG+
Sbjct: 2277 LGEGGAHKVRAGGTGLERGVAGVPAEFSIWTREAGAGGLSIAVEGPSKAEIAFEDRKDGS 2336

Query: 558  CSVSYLPVLPGDYSILVKYNEQHIPGSPFTARVTG--DDSMRMS-------HLKVGSAAD 710
            C VSY+   PGDY + +K+N++HIP SPF   V    DD+ R++        LKV   A 
Sbjct: 2337 CGVSYVVQEPGDYEVSIKFNDEHIPDSPFVVPVASLSDDARRLTVTSLQETGLKVNQPAS 2396

Query: 711  IPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNGQHV 890
              + ++     ++ A V  PSG  E C +  L +    I F+P E G H + VK NG H+
Sbjct: 2397 FAVQLNGAR-GVIDARVHTPSGAVEECYVSELDSDKHTIRFIPHENGVHSIDVKFNGAHI 2455

Query: 891  ASSPIPVVIS-QSEIGDASRVRVSGRGLHEGHTFEPAEFIIDTRDAGYGGLSLSIEGPSK 1067
              SP  + +  QS+ GD   V   G GL  G T   +EFI++T +AG G LS++I+GPSK
Sbjct: 2456 PGSPFKIRVGEQSQAGDPGLVSAYGPGLEGGTTGVSSEFIVNTLNAGSGALSVTIDGPSK 2515

Query: 1068 VDINTEDLEDGTCRVTYCPTEPGNYIINIKF-ADQHVPGSPFSVKVTG------------ 1208
            V ++  +  +G   VTY P  PGNY+I IK+   QH+ GSPF  KVTG            
Sbjct: 2516 VQLDCRECPEGHV-VTYTPMAPGNYLIAIKYGGPQHIVGSPFKAKVTGPRLSGGHSLHET 2574

Query: 1209 -----EGRVKESITRRQ-----------------RAP--SVANVGSHCDLSLKIPEISIQ 1316
                 E   K S +R                   R P  S A VG     ++   +    
Sbjct: 2575 STVLVETVTKSSSSRGSSYSSIPKFSSDASKVVTRGPGLSQAFVGQKNSFTVDCSKAGTN 2634

Query: 1317 DMTAQVTSPSGKSHEAEIVEGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTV 1490
             M   V  P     E  +    N  Y + +   E G + + VK+  + VPGSPF+  V
Sbjct: 2635 MMMVGVHGPKTPCEEVYVKHVGNRVYNVTYTVKEKGDYILIVKWGDESVPGSPFKVNV 2692



 Score =  236 bits (602), Expect = 6e-62
 Identities = 237/840 (28%), Positives = 367/840 (43%), Gaps = 47/840 (5%)
 Frame = +3

Query: 354  PGSPLQFYVDYVNCGHVTAYGPGLSH--GVVNKPAVFTVNTKDAGEGGLSLAIEGP---- 515
            PG+P++     +N     AYGPG+      V +PA FTV T DAG G + + IE P    
Sbjct: 265  PGAPVRS--KQLNPKKAIAYGPGIEPQGNTVLQPAHFTVQTVDAGVGEVLVYIEDPEGHT 322

Query: 516  SKAEISCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARV---TGDD---SMR 677
             +A++   +++D T +VSY+P + G + + V +  Q+I  SPF   V    GD    S R
Sbjct: 323  EEAKVVPNNDKDRTYAVSYVPKVAGLHKVTVLFAGQNIERSPFEVNVGMALGDANKVSAR 382

Query: 678  MSHLK-VGSAADIP----INISETDLSLLTATVVPPSGREE--PCLLKRLRNGHVGISFV 836
               L+ VG+ A+ P    I  +      +   +V P GR +     L+   +     ++ 
Sbjct: 383  GPGLEPVGNVANKPTYFDIYTAGAGTGDVAVVIVDPQGRRDTVEVALEDKGDSTFRCTYR 442

Query: 837  PKETGEHLVHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEG--HTFEPAEFII 1010
            P   G H VHV   G  +  SP PV +  +E  + +  R SGRGL        E A+F +
Sbjct: 443  PVMEGPHTVHVAFAGAPITRSPFPVHV--AEACNPNACRASGRGLQPKGVRVKEVADFKV 500

Query: 1011 DTRDAGYGGLSLSIEGPSKVD--INTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGS 1184
             T+ AG G L ++++GP   +  +   D  DG     Y P  PG Y++ I +    +P S
Sbjct: 501  FTKGAGSGELKVTVKGPKGTEEPVKVRDAGDGVFECEYYPVVPGKYVVTITWGGYAIPRS 560

Query: 1185 PFSVKVTGEGRVKESITRRQRAPSV--ANVGSHCDLSLKIPEISIQDMTAQVTSPSGKSH 1358
            PF V+V+ E  +++    R   P +    VG   D  ++     +  +   +  PS    
Sbjct: 561  PFEVQVSPEAGMQKV---RAWGPGLETGQVGKSADFVVEAIGTEVGTLGFSIEGPSQAKI 617

Query: 1359 EAEIVEGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPL-GEGGAHKVRAGG 1535
            E +  +  + +  +R+ P E G + V V    + +  SPF   + P   +    KV+A G
Sbjct: 618  ECD--DKGDGSCDVRYWPTEPGEYAVHVICDDEDIRDSPFIAHIQPAPPDCFPDKVKAFG 675

Query: 1536 PGLERAEAGV--PAEFSIWTREAGAGGLAIAVEGPSKAEISFE--DRKDGSCGVAYVVQE 1703
            PGLE     V  PAEF+I  R AG G L +  +      I  +     DG+   +YV  +
Sbjct: 676  PGLEPTGCIVDKPAEFTIDARAAGKGDLKLYAQDADGCPIDIKVIPNGDGTFRCSYVPTK 735

Query: 1704 PGDYEVSVKFNEEHIPDSPFVVPVASPSGDAR-RLTVSSLQESGLKVNQPASFAVSLNGA 1880
            P  + + + +   ++P SPF V V   S   R ++    ++++GLK N+P  F V  + A
Sbjct: 736  PIKHTIIISWGGVNVPKSPFRVNVGEGSHPERVKVYGPGVEKTGLKANEPTYFTVDCSEA 795

Query: 1881 -KGAIDAKVH------SPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPG 2039
             +G +   +        P+ A  +  + + D D + V++ P   G Y I V F    IP 
Sbjct: 796  GQGDVSIGIKCAPGVVGPAEADIDFDIIKNDNDTFTVKYTPPGAGRYTIMVLFANQEIPA 855

Query: 2040 SPFKIRVGEPGHGGDPGLVSAYGAGLE--GGVTGSPAEFIVNTSNAGAGALSVTIDGPSK 2213
            SPF I+V +P H  D   V A G GL   G   G P  F V T  AG   L V   G +K
Sbjct: 856  SPFHIKV-DPSH--DASKVKAEGPGLNRTGVEVGKPTHFTVLTKGAGKAKLDVHFAGAAK 912

Query: 2214 VKM-----DCQECPEGYRVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHS 2378
             +              Y V YT +  G+  +++ YGG   +  SPF   V          
Sbjct: 913  GEAVRDFEIIDNHDYSYTVKYTAVQQGNMAVTVTYGGD-PVPKSPFVVNVA--------- 962

Query: 2379 LHETSSVFVDSLTKTXXXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKA- 2555
                                           SKV  +GL  SK  VGQ+ +F+V+   A 
Sbjct: 963  --------------------------PPLDLSKVKVQGLN-SKVAVGQEQAFSVNTRGAG 995

Query: 2556 GNNMLLVGVHGP-RTPCEEILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRV 2732
            G   L V +  P R P    L    G+   +V Y+  ++G Y + + +    +PGSP+ V
Sbjct: 996  GQGQLDVRMTSPSRRPIPCKLEPGGGADAQAVRYMPPEEGPYKVDITYDGHPVPGSPFAV 1055



 Score =  130 bits (327), Expect = 4e-30
 Identities = 91/311 (29%), Positives = 139/311 (44%), Gaps = 53/311 (17%)
 Frame = +3

Query: 138  VNGLDVTSLR---PFDLVIPFTIKKGEITGEVRMPSGKVAQPAITDNKDGTVTVRYAPSE 308
            V  L  T L+   P    +     +G I   V  PSG V +  +++      T+R+ P E
Sbjct: 2381 VTSLQETGLKVNQPASFAVQLNGARGVIDARVHTPSGAVEECYVSELDSDKHTIRFIPHE 2440

Query: 309  AGLHEMDIRYDNMHIPGSPLQFYVDYVNC----GHVTAYGPGLSHGVVNKPAVFTVNTKD 476
             G+H +D++++  HIPGSP +  V   +     G V+AYGPGL  G     + F VNT +
Sbjct: 2441 NGVHSIDVKFNGAHIPGSPFKIRVGEQSQAGDPGLVSAYGPGLEGGTTGVSSEFIVNTLN 2500

Query: 477  AGEGGLSLAIEGPSKAEISCTDNQDGTCSVSYLPVLPGDYSILVKY-NEQHIPGSPFTAR 653
            AG G LS+ I+GPSK ++ C +  +G   V+Y P+ PG+Y I +KY   QHI GSPF A+
Sbjct: 2501 AGSGALSVTIDGPSKVQLDCRECPEGHV-VTYTPMAPGNYLIAIKYGGPQHIVGSPFKAK 2559

Query: 654  VTG----------------------DDSMR-----------------------MSHLKVG 698
            VTG                        S R                       +S   VG
Sbjct: 2560 VTGPRLSGGHSLHETSTVLVETVTKSSSSRGSSYSSIPKFSSDASKVVTRGPGLSQAFVG 2619

Query: 699  SAADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKN 878
                  ++ S+   +++   V  P    E   +K + N    +++  KE G++++ VK  
Sbjct: 2620 QKNSFTVDCSKAGTNMMMVGVHGPKTPCEEVYVKHVGNRVYNVTYTVKEKGDYILIVKWG 2679

Query: 879  GQHVASSPIPV 911
             + V  SP  V
Sbjct: 2680 DESVPGSPFKV 2690


>ref|XP_003362247.1| PREDICTED: filamin-A-like, partial [Sus scrofa].
          Length = 301

 Score =  480 bits (1236), Expect = e-135
 Identities = 260/345 (75%), Positives = 261/345 (75%)
 Frame = +3

Query: 486  GGLSLAIEGPSKAEISCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARVTGD 665
            GGLSLAIEGPSKAEISCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARVTGD
Sbjct: 32   GGLSLAIEGPSKAEISCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARVTGD 91

Query: 666  DSMRMSHLKVGSAADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKE 845
            DSMRMSHLKVGSAADIPINISETDLSLLTAT+   S                        
Sbjct: 92   DSMRMSHLKVGSAADIPINISETDLSLLTATIGDAS------------------------ 127

Query: 846  TGEHLVHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEGHTFEPAEFIIDTRDA 1025
                 V V   G H                             EGHTFEPAEFIIDTR  
Sbjct: 128  ----RVRVSGRGLH-----------------------------EGHTFEPAEFIIDTR-- 152

Query: 1026 GYGGLSLSIEGPSKVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVT 1205
             YGGLSLSIEGPSKVDINTEDLEDGTCRVTYCPTE               PGSPFSVKVT
Sbjct: 153  -YGGLSLSIEGPSKVDINTEDLEDGTCRVTYCPTE---------------PGSPFSVKVT 196

Query: 1206 GEGRVKESITRRQRAPSVANVGSHCDLSLKIPEISIQDMTAQVTSPSGKSHEAEIVEGEN 1385
            GEGRVKESITRRQRAPSVANVGSHCDLSLKIPEISIQDMTAQVTSPSGKSHEAEIVEGEN
Sbjct: 197  GEGRVKESITRRQRAPSVANVGSHCDLSLKIPEISIQDMTAQVTSPSGKSHEAEIVEGEN 256

Query: 1386 HTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHK 1520
            HTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHK
Sbjct: 257  HTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHK 301



 Score =  182 bits (463), Expect = 7e-46
 Identities = 122/319 (38%), Positives = 157/319 (49%), Gaps = 44/319 (13%)
 Frame = +3

Query: 123 RPLVGVNGLDVTSLRPFDLVIPFTIKKGEITG--EVRMPSGKVAQPAITDNKDGTVTVRY 296
           RPLVGVNGLDVTSLRPFDLVIPFTIKKGEITG   + +     A+ + TDN+DGT +V Y
Sbjct: 1   RPLVGVNGLDVTSLRPFDLVIPFTIKKGEITGGLSLAIEGPSKAEISCTDNQDGTCSVSY 60

Query: 297 APSEAGLHEMDIRYDNMHIPGSPLQFYV---DYVNCGH---------------------- 401
            P   G + + ++Y+  HIPGSP    V   D +   H                      
Sbjct: 61  LPVLPGDYSILVKYNEQHIPGSPFTARVTGDDSMRMSHLKVGSAADIPINISETDLSLLT 120

Query: 402 --------VTAYGPGLSHGVVNKPAVFTVNTKDAGEGGLSLAIEGPSKAEISCTDNQDGT 557
                   V   G GL  G   +PA F ++T+    GGLSL+IEGPSK +I+  D +DGT
Sbjct: 121 ATIGDASRVRVSGRGLHEGHTFEPAEFIIDTR---YGGLSLSIEGPSKVDINTEDLEDGT 177

Query: 558 CSVSYLPVLPGDYSILVKYNEQHIPGSPFTARVTGDDSMRMSHLK---------VGSAAD 710
           C V+Y P  PG               SPF+ +VTG+  ++ S  +         VGS  D
Sbjct: 178 CRVTYCPTEPG---------------SPFSVKVTGEGRVKESITRRQRAPSVANVGSHCD 222

Query: 711 IPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNGQHV 890
           + + I E  +  +TA V  PSG+     +    N    I FVP E G H V VK  GQHV
Sbjct: 223 LSLKIPEISIQDMTAQVTSPSGKSHEAEIVEGENHTYCIRFVPAEMGMHTVSVKYKGQHV 282

Query: 891 ASSPIPVVISQSEIGDASR 947
             SP    +     G A +
Sbjct: 283 PGSPFQFTVGPLGEGGAHK 301



 Score =  129 bits (325), Expect = 7e-30
 Identities = 89/275 (32%), Positives = 131/275 (47%), Gaps = 34/275 (12%)
 Frame = +3

Query: 1359 EAEIVEGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPF-------------QFTVGPL 1499
            E    + ++ T  + ++P   G +++ VKY  QH+PGSPF                VG  
Sbjct: 45   EISCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARVTGDDSMRMSHLKVGSA 104

Query: 1500 GE-----------------GGAHKVRAGGPGLERAEAGVPAEFSIWTREAGAGGLAIAVE 1628
             +                 G A +VR  G GL       PAEF I TR    GGL++++E
Sbjct: 105  ADIPINISETDLSLLTATIGDASRVRVSGRGLHEGHTFEPAEFIIDTRY---GGLSLSIE 161

Query: 1629 GPSKAEISFEDRKDGSCGVAYVVQEPGDYEVSVKFNEEHIPDSPFVVPVASPSGDAR-RL 1805
            GPSK +I+ ED +DG+C V Y   EPG               SPF V V   +G+ R + 
Sbjct: 162  GPSKVDINTEDLEDGTCRVTYCPTEPG---------------SPFSVKV---TGEGRVKE 203

Query: 1806 TVSSLQESGLKVNQPASFAVSLNGAKGAID---AKVHSPSGALEECYVTEIDQDKYAVRF 1976
            +++  Q +    N  +   +SL   + +I    A+V SPSG   E  + E +   Y +RF
Sbjct: 204  SITRRQRAPSVANVGSHCDLSLKIPEISIQDMTAQVTSPSGKSHEAEIVEGENHTYCIRF 263

Query: 1977 IPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGG 2081
            +P E G++ + VK+ G H+PGSPF+  VG  G GG
Sbjct: 264  VPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGG 298



 Score =  112 bits (280), Expect = 1e-24
 Identities = 102/379 (26%), Positives = 155/379 (40%), Gaps = 1/379 (0%)
 Frame = +3

Query: 1605 GGLAIAVEGPSKAEISFEDRKDGSCGVAYVVQEPGDYEVSVKFNEEHIPDSPFVVPVASP 1784
            GGL++A+EGPSKAEIS  D +DG+C V+Y+   PGDY + VK+NE+HIP SPF   V   
Sbjct: 32   GGLSLAIEGPSKAEISCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARV--- 88

Query: 1785 SGDARRLTVSSLQESGLKVNQPASFAVSLNGAKGAIDAKVHSPSGALEECYVTEIDQDKY 1964
            +GD       S++ S LKV   A   ++++                              
Sbjct: 89   TGD------DSMRMSHLKVGSAADIPINIS------------------------------ 112

Query: 1965 AVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPGLVSAYGAGLEGGVTGSPA 2144
                   E  + L+      T   G   ++RV   G              L  G T  PA
Sbjct: 113  -------ETDLSLL------TATIGDASRVRVSGRG--------------LHEGHTFEPA 145

Query: 2145 EFIVNTSNAGAGALSVTIDGPSKVKMDCQECPEG-YRVTYTPMAPGSYLISIKYGGPYHI 2321
            EFI++T     G LS++I+GPSKV ++ ++  +G  RVTY P  P               
Sbjct: 146  EFIIDTR---YGGLSLSIEGPSKVDINTEDLEDGTCRVTYCPTEP--------------- 187

Query: 2322 GGSPFKARVTGHRLVSNHSLHETSSVFVDSLTKTXXXXXXXXXXXXXXXXSKVLAKGLGL 2501
             GSPF  +VTG   V             +S+T+                      +    
Sbjct: 188  -GSPFSVKVTGEGRVK------------ESITR----------------------RQRAP 212

Query: 2502 SKAYVGQKGSFTVDCSKAGNNMLLVGVHGPRTPCEEILVKHVGSRLYSVSYLLKDKGEYT 2681
            S A VG     ++   +     +   V  P     E  +    +  Y + ++  + G +T
Sbjct: 213  SVANVGSHCDLSLKIPEISIQDMTAQVTSPSGKSHEAEIVEGENHTYCIRFVPAEMGMHT 272

Query: 2682 LVVKWGDEHIPGSPYRVLV 2738
            + VK+  +H+PGSP++  V
Sbjct: 273  VSVKYKGQHVPGSPFQFTV 291


>ref|XP_003132317.2| PREDICTED: filamin-B-like [Sus scrofa].
          Length = 1997

 Score =  325 bits (832), Expect = 1e-88
 Identities = 242/787 (30%), Positives = 368/787 (46%), Gaps = 70/787 (8%)
 Frame = +3

Query: 201  KGEITGEVRMPSGKVAQPAITDNKDG--TVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQF 374
            +G++   +  PS KV  P +     G  + T ++ P E GL+ +D+ YD   +PGSP   
Sbjct: 974  QGKLDVTILSPSRKVV-PCLVAPVAGRESSTAKFIPREEGLYAVDVTYDGHPVPGSPYMV 1032

Query: 375  YVDYV-NCGHVTAYGPGLSHGVVNKPAVFTVNTKDAGEGGLSLAIEGPSKAEISCTDNQD 551
                  +   V A+GPGL  G+V KPA FT++TK AG GGL L +EGP +A+I C+DN D
Sbjct: 1033 EASLPPDPTKVKAHGPGLEGGLVGKPAEFTIDTKGAGTGGLGLTVEGPCEAKIECSDNGD 1092

Query: 552  GTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARV--------TGDDSMRMSHLKVGSAA 707
            GTCSVSYLP  PG+Y + + + E HIPGSPF A +               + H KVG A 
Sbjct: 1093 GTCSVSYLPTKPGEYFVNILFEEVHIPGSPFKADIEMPFDPSKVVASGPGLEHGKVGEAG 1152

Query: 708  DIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNGQH 887
             + ++ SE     L    V  SG +    ++  ++G   +++VP   G + + +K  G+ 
Sbjct: 1153 LLSVDCSEAGPGTLGLEAVSDSGAKAEVCIENNKDGTYAVTYVPLTAGMYTLTMKYGGEL 1212

Query: 888  VASSPIPVVISQSEIGDASRVRVSGRGLHEGHTFEPA--EFIIDTR---DAGYGGLSLSI 1052
            V   P  V +  +   D SRV+V G G+     F  A  +F +D+R     G   +   I
Sbjct: 1213 VPHFPARVKVEPAV--DTSRVKVFGPGIEGKDVFREATTDFTVDSRPLTQVGGDHIKAHI 1270

Query: 1053 EGPS--KVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVT------- 1205
              PS    +    D  DGT +V Y P E G +++ + + D  +P SPF V VT       
Sbjct: 1271 ANPSGASTECFVTDNADGTYQVEYTPFEKGLHVVEVTYDDVPIPNSPFKVAVTEGCQPSR 1330

Query: 1206 ----GEGRVKESITRRQRAPSVANVGSHCDLSLKIPEISIQDMTAQVTSPSGKSHEAEIV 1373
                G G +KE+ T +    +V   G+            I  +   V  PS    +    
Sbjct: 1331 VQAQGPG-LKEAFTNKPNVFTVVTRGA-----------GIGGLGITVEGPS--ESKINCR 1376

Query: 1374 EGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGL-ER 1550
            + ++ +    ++P   G + V++ Y G H+PGSPF+  V  + +    KV+  GPGL   
Sbjct: 1377 DNKDGSCSAEYIPFAPGDYDVNITYGGAHIPGSPFRVPVKDVVD--PSKVKIAGPGLGSG 1434

Query: 1551 AEAGVPAEFSIWTREAGAGGLAIAVEGPSKAEISFEDRK--------------------- 1667
              A +   F++ + +AG   L + V GP   E   + R+                     
Sbjct: 1435 VRARILQSFTVDSSKAGLAPLEVRVLGPRAVETDSQSRRSPLKAISEFFKRDLKGDFMET 1494

Query: 1668 ------------DGSCGVAYVVQEPGDYEVSVKFNEEHIPDSPFVVPVASPSGDARRLTV 1811
                        DG+  V Y   + G Y VSVK+ +E IP SPF V V  P+ DA ++T 
Sbjct: 1495 GLVEPVNVVDNGDGTHTVTYTPSQEGPYMVSVKYADEEIPRSPFKVKVL-PTYDASKVTA 1553

Query: 1812 S--SLQESGLKVNQPASFAVSLNGA-KGAIDAKVHSPSGALEECYVTEIDQDKYAVRFIP 1982
            S   L   G+  + P  FA+    A +G +  ++    G  +   V +     YAV +IP
Sbjct: 1554 SGPGLSTYGVPASLPVEFAIDARDAGEGLLAVQITDQEGKPKRAIVHDNKDGTYAVTYIP 1613

Query: 1983 RENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPGLVSAYGAGLEGGV-TGSPAEFIVN 2159
             + G Y+I V + G  IP SP++IR  +    GD     A G G+   V TG    F+V+
Sbjct: 1614 DKTGRYMIGVTYGGDDIPLSPYRIRATQT---GDASKCLATGPGIASTVKTGEEVGFVVD 1670

Query: 2160 TSNAGAGALSVTIDGP--SKVKMDCQECPEG-YRVTYTPMAPGSYLISIKYGGPYHIGGS 2330
               AG G ++ T+  P  ++ + D  E  +G Y + YT   PG+Y+I +++GG   I  S
Sbjct: 1671 AKTAGKGKVTCTVLTPDGTEAEADVIENEDGTYDIFYTAAKPGTYVIYVRFGG-VDIPNS 1729

Query: 2331 PFKARVT 2351
            PF    T
Sbjct: 1730 PFTVMAT 1736



 Score =  298 bits (764), Expect = 9e-81
 Identities = 245/895 (27%), Positives = 385/895 (43%), Gaps = 52/895 (5%)
 Frame = +3

Query: 201  KGEITGEVRMPSGKVAQPAIT--DNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQF 374
            +G++   V  P G   +  +T   +K+ T +V Y P   GLH++ + +   HI  SP + 
Sbjct: 286  QGDVMVFVEDPEGNKEEAHVTPDSDKNKTYSVEYLPKVTGLHKVTVLFAGQHISKSPFEV 345

Query: 375  YVDYV--NCGHVTAYGPGL--SHGVVNKPAVFTVNTKDAGEGGLSLAIEGP---SKAEIS 533
             VD    +   VTA GPGL  S  + NKP  F + T  AG G + + +E P   +  E+ 
Sbjct: 346  NVDKAQGDASKVTAKGPGLEASGNIANKPTYFDIYTAGAGVGDIGVEVEDPQGKNTVELL 405

Query: 534  CTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARV----------TGDDSMRMS 683
              D  +      Y P+ PG + I V +    IP SPF  +V               ++  
Sbjct: 406  VEDKGNQVYRCVYKPMQPGPHVIKVSFAGDTIPKSPFVVQVGEACNPNACRASGRGLQPK 465

Query: 684  HLKVGSAADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLV 863
             +++   AD  ++        L  TV  P G EE    K   +G     + P   G++ +
Sbjct: 466  GIRIRETADFKVDTKAAGSGELGVTVKGPKGLEELVKQKGFLDGVYSFEYYPSTPGKYSI 525

Query: 864  HVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEGHTFEPAEFIIDTRDAGYGGLS 1043
             +   G H+  SP  V +         +VR  G GLH G     A+F++++  +  G L 
Sbjct: 526  AIMWGGHHIPKSPFEVQVGPE--AGMQKVRAWGPGLHGGIVGRSADFVVESIGSEVGSLG 583

Query: 1044 LSIEGPSKVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTGEGRVK 1223
             +IEGPS+  I  +D  DG+C V Y P EPG Y ++I   D+ +  SP+   +       
Sbjct: 584  FAIEGPSQAKIEYDDQNDGSCDVKYWPKEPGEYAVHIMCDDEDIKDSPYMAFIHPASGDY 643

Query: 1224 ESITRRQRAPSVANVGSHCDLSLKIPEISIQDMTA-----QVTSPSGKSH--EAEIVEGE 1382
                 +   P +   G   D    + E ++    A     ++ +  G+    + ++    
Sbjct: 644  NPDLVQAYGPGLEKSGCIVD---NLAEFTVDPKNAGKAPLKILAQDGEGQPIDIQMKSRM 700

Query: 1383 NHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAH--KVRAGGPGLERA- 1553
            + TY   + P +   HT++V + G ++P SP++  +G     G+H  KV+  GPG+ER+ 
Sbjct: 701  DGTYACSYTPVKPIKHTIAVVWGGVNIPNSPYRVNIGQ----GSHPQKVKVFGPGVERSG 756

Query: 1554 -EAGVPAEFSIWTREAGAGGLAIAVEGPSKAEISFEDRKD----------GSCGVAYVVQ 1700
             +A  P  F++   EAG G +++ ++    A +  ED +D           +  V YV  
Sbjct: 757  LKANEPTHFTVDCTEAGEGDVSVGIK--CDARVLSEDEEDVDFDIIHNANDTFTVKYVPP 814

Query: 1701 EPGDYEVSVKFNEEHIPDSPFVVPVASPSGDARRLTVS--SLQESGLKVNQPASFAVSLN 1874
              G Y + V F  + IP SPF V V  PS DA ++      L +SG++  +P  F V   
Sbjct: 815  AAGRYTIKVLFASQEIPASPFRVRV-DPSHDASKVKAEGPGLSKSGVENGKPTHFTVYTK 873

Query: 1875 GA-KGAIDAKVHS--PSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSP 2045
            GA K  ++ +  S  P  A+++  V +     + V++ P + G   + V + G  IP SP
Sbjct: 874  GAGKAPLNVQFSSPLPGDAVKDLDVIDNYDYSHTVKYTPTQQGTMHVLVTYGGDPIPESP 933

Query: 2046 FKIRVGEPGHGGDPGLVSAYGAGLEGGV-TGSPAEFIVNTSNAGA-GALSVTIDGPSKVK 2219
            F + V  P       L      GLE  V  G   EF ++T  AG  G L VTI  PS+  
Sbjct: 934  FTVAVAAP-----LDLSRIKVNGLENRVEVGKDQEFAIDTRGAGGQGKLDVTILSPSRKV 988

Query: 2220 MDCQECP----EGYRVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHE 2387
            + C   P    E     + P   G Y + + Y G + + GSP+    +            
Sbjct: 989  VPCLVAPVAGRESSTAKFIPREEGLYAVDVTYDG-HPVPGSPYMVEAS------------ 1035

Query: 2388 TSSVFVDSLTKTXXXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKAGNNM 2567
                                        +KV A G GL    VG+   FT+D   AG   
Sbjct: 1036 -----------------------LPPDPTKVKAHGPGLEGGLVGKPAEFTIDTKGAGTGG 1072

Query: 2568 LLVGVHGPRTPCE-EILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYR 2729
            L + V G   PCE +I     G    SVSYL    GEY + + + + HIPGSP++
Sbjct: 1073 LGLTVEG---PCEAKIECSDNGDGTCSVSYLPTKPGEYFVNILFEEVHIPGSPFK 1124



 Score =  288 bits (738), Expect = 1e-77
 Identities = 256/902 (28%), Positives = 382/902 (42%), Gaps = 66/902 (7%)
 Frame = +3

Query: 228  MPSGKVAQPAITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFYVDY-VNCGHV 404
            +P   V    + DN D + TV+Y P++ G   + + Y    IP SP    V   ++   +
Sbjct: 888  LPGDAVKDLDVIDNYDYSHTVKYTPTQQGTMHVLVTYGGDPIPESPFTVAVAAPLDLSRI 947

Query: 405  TAYGPGLSHGV-VNKPAVFTVNTKDAG-EGGLSLAIEGPSKAEISCTDNQDG---TCSVS 569
               G  L + V V K   F ++T+ AG +G L + I  PS+  + C         + +  
Sbjct: 948  KVNG--LENRVEVGKDQEFAIDTRGAGGQGKLDVTILSPSRKVVPCLVAPVAGRESSTAK 1005

Query: 570  YLPVLPGDYSILVKYNEQHIPGSPFT--ARVTGDDSMRMSHLK------VGSAADIPINI 725
            ++P   G Y++ V Y+   +PGSP+   A +  D +   +H        VG  A+  I+ 
Sbjct: 1006 FIPREEGLYAVDVTYDGHPVPGSPYMVEASLPPDPTKVKAHGPGLEGGLVGKPAEFTIDT 1065

Query: 726  SETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNGQHVASSPI 905
                   L  TV  P   +  C      +G   +S++P + GE+ V++     H+  SP 
Sbjct: 1066 KGAGTGGLGLTVEGPCEAKIEC--SDNGDGTCSVSYLPTKPGEYFVNILFEEVHIPGSPF 1123

Query: 906  PVVISQSEIGDASRVRVSGRGLHEGHTFEPAEFIIDTRDAGYGGLSLSIEGPS--KVDIN 1079
               I      D S+V  SG GL  G   E     +D  +AG G L L     S  K ++ 
Sbjct: 1124 KADIEMPF--DPSKVVASGPGLEHGKVGEAGLLSVDCSEAGPGTLGLEAVSDSGAKAEVC 1181

Query: 1080 TEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVT-----------GEGRVKE 1226
             E+ +DGT  VTY P   G Y + +K+  + VP  P  VKV            G G   +
Sbjct: 1182 IENNKDGTYAVTYVPLTAGMYTLTMKYGGELVPHFPARVKVEPAVDTSRVKVFGPGIEGK 1241

Query: 1227 SITRRQRAPSVANVGSHCDLSLKIPEISIQDMTAQVTSPSGKSHEAEIVEGENHTYCIRF 1406
             + R        +       S  + ++    + A + +PSG S E  + +  + TY + +
Sbjct: 1242 DVFREATTDFTVD-------SRPLTQVGGDHIKAHIANPSGASTECFVTDNADGTYQVEY 1294

Query: 1407 VPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEG-GAHKVRAGGPGLERAEAGVPAEFSI 1583
             P E G+H V V Y    +P SPF+  V    EG    +V+A GPGL+ A    P  F++
Sbjct: 1295 TPFEKGLHVVEVTYDDVPIPNSPFKVAVT---EGCQPSRVQAQGPGLKEAFTNKPNVFTV 1351

Query: 1584 WTREAGAGGLAIAVEGPSKAEISFEDRKDGSCGVAYVVQEPGDYEVSVKFNEEHIPDSPF 1763
             TR AG GGL I VEGPS+++I+  D KDGSC   Y+   PGDY+V++ +   HIP SPF
Sbjct: 1352 VTRGAGIGGLGITVEGPSESKINCRDNKDGSCSAEYIPFAPGDYDVNITYGGAHIPGSPF 1411

Query: 1764 VVPVASPSGDARRLTVSSLQESGLKVNQPASFAV-SLNGAKGAIDAKVHSP--------- 1913
             VPV      ++         SG++     SF V S       ++ +V  P         
Sbjct: 1412 RVPVKDVVDPSKVKIAGPGLGSGVRARILQSFTVDSSKAGLAPLEVRVLGPRAVETDSQS 1471

Query: 1914 ----------------------SGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGT 2027
                                  +G +E   V +     + V + P + G Y++ VK+   
Sbjct: 1472 RRSPLKAISEFFKRDLKGDFMETGLVEPVNVVDNGDGTHTVTYTPSQEGPYMVSVKYADE 1531

Query: 2028 HIPGSPFKIRVGEPGHGGDPGLVSAYGAGLEG-GVTGS-PAEFIVNTSNAGAGALSVTI- 2198
             IP SPFK++V  P +  D   V+A G GL   GV  S P EF ++  +AG G L+V I 
Sbjct: 1532 EIPRSPFKVKV-LPTY--DASKVTASGPGLSTYGVPASLPVEFAIDARDAGEGLLAVQIT 1588

Query: 2199 --DGPSKVKMDCQECPEGYRVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSN 2372
              +G  K  +        Y VTY P   G Y+I + YGG   I  SP++ R T       
Sbjct: 1589 DQEGKPKRAIVHDNKDGTYAVTYIPDKTGRYMIGVTYGGD-DIPLSPYRIRAT------- 1640

Query: 2373 HSLHETSSVFVDSLTKTXXXXXXXXXXXXXXXXSKVLAKGLGL-SKAYVGQKGSFTVDCS 2549
                +T                           SK LA G G+ S    G++  F VD  
Sbjct: 1641 ----QTGDA------------------------SKCLATGPGIASTVKTGEEVGFVVDAK 1672

Query: 2550 KAGNNMLLVGVHGPRTPCEEILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYR 2729
             AG   +   V  P     E  V       Y + Y     G Y + V++G   IP SP+ 
Sbjct: 1673 TAGKGKVTCTVLTPDGTEAEADVIENEDGTYDIFYTAAKPGTYVIYVRFGGVDIPNSPFT 1732

Query: 2730 VL 2735
            V+
Sbjct: 1733 VM 1734



 Score =  287 bits (734), Expect = 3e-77
 Identities = 252/881 (28%), Positives = 387/881 (43%), Gaps = 48/881 (5%)
 Frame = +3

Query: 264  DNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFYV-----DYVNCGHVTAYGPGLS 428
            D  DG+  V+Y P E G + + I  D+  I  SP   ++     DY N   V AYGPGL 
Sbjct: 598  DQNDGSCDVKYWPKEPGEYAVHIMCDDEDIKDSPYMAFIHPASGDY-NPDLVQAYGPGLE 656

Query: 429  HG--VVNKPAVFTVNTKDAGEGGLS-LAIEGPSKA-EISCTDNQDGTCSVSYLPVLPGDY 596
                +V+  A FTV+ K+AG+  L  LA +G  +  +I      DGT + SY PV P  +
Sbjct: 657  KSGCIVDNLAEFTVDPKNAGKAPLKILAQDGEGQPIDIQMKSRMDGTYACSYTPVKPIKH 716

Query: 597  SILVKYNEQHIPGSPFTARVTGDDS-----------MRMSHLKVGSAADIPINISET--- 734
            +I V +   +IP SP+   + G  S           +  S LK        ++ +E    
Sbjct: 717  TIAVVWGGVNIPNSPYRVNI-GQGSHPQKVKVFGPGVERSGLKANEPTHFTVDCTEAGEG 775

Query: 735  DLSL---LTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNGQHVASSPI 905
            D+S+     A V+     +    +    N    + +VP   G + + V    Q + +SP 
Sbjct: 776  DVSVGIKCDARVLSEDEEDVDFDIIHNANDTFTVKYVPPAAGRYTIKVLFASQEIPASPF 835

Query: 906  PVVISQSEIGDASRVRVSGRGLHEG--HTFEPAEFIIDTRDAGYGGLSLSIEGP----SK 1067
             V +  S   DAS+V+  G GL +      +P  F + T+ AG   L++    P    + 
Sbjct: 836  RVRVDPSH--DASKVKAEGPGLSKSGVENGKPTHFTVYTKGAGKAPLNVQFSSPLPGDAV 893

Query: 1068 VDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTGE---GRVKESITR 1238
             D++  D  D +  V Y PT+ G   + + +    +P SPF+V V       R+K +   
Sbjct: 894  KDLDVIDNYDYSHTVKYTPTQQGTMHVLVTYGGDPIPESPFTVAVAAPLDLSRIKVNGLE 953

Query: 1239 RQRAPSVANVGSHCDLSLKIPEISIQD-MTAQVTSPSGKSHE---AEIVEGENHTYCIRF 1406
             +       VG   + ++       Q  +   + SPS K      A +   E+ T   +F
Sbjct: 954  NR-----VEVGKDQEFAIDTRGAGGQGKLDVTILSPSRKVVPCLVAPVAGRESST--AKF 1006

Query: 1407 VPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLERAEAGVPAEFSIW 1586
            +P E G++ V V Y G  VPGSP+        +    KV+A GPGLE    G PAEF+I 
Sbjct: 1007 IPREEGLYAVDVTYDGHPVPGSPYMVEASLPPD--PTKVKAHGPGLEGGLVGKPAEFTID 1064

Query: 1587 TREAGAGGLAIAVEGPSKAEISFEDRKDGSCGVAYVVQEPGDYEVSVKFNEEHIPDSPFV 1766
            T+ AG GGL + VEGP +A+I   D  DG+C V+Y+  +PG+Y V++ F E HIP SPF 
Sbjct: 1065 TKGAGTGGLGLTVEGPCEAKIECSDNGDGTCSVSYLPTKPGEYFVNILFEEVHIPGSPFK 1124

Query: 1767 VPVASPSGDARRLTVSSLQESGLKVNQPASFAVSLNGA-KGAIDAKVHSPSGALEECYVT 1943
              +  P   ++ +      E G KV +    +V  + A  G +  +  S SGA  E  + 
Sbjct: 1125 ADIEMPFDPSKVVASGPGLEHG-KVGEAGLLSVDCSEAGPGTLGLEAVSDSGAKAEVCIE 1183

Query: 1944 EIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPGLVSAYGAGLEG 2123
                  YAV ++P   G+Y + +K+ G  +P  P +++V EP    D   V  +G G+EG
Sbjct: 1184 NNKDGTYAVTYVPLTAGMYTLTMKYGGELVPHFPARVKV-EP--AVDTSRVKVFGPGIEG 1240

Query: 2124 G--VTGSPAEFIVNT---SNAGAGALSVTIDGPSKVKMDC---QECPEGYRVTYTPMAPG 2279
                  +  +F V++   +  G   +   I  PS    +C         Y+V YTP   G
Sbjct: 1241 KDVFREATTDFTVDSRPLTQVGGDHIKAHIANPSGASTECFVTDNADGTYQVEYTPFEKG 1300

Query: 2280 SYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSVFVDSLTKTXXXXXXXXXXXX 2459
             +++ + Y     I  SPFK  VT                                    
Sbjct: 1301 LHVVEVTY-DDVPIPNSPFKVAVT-----------------------------------E 1324

Query: 2460 XXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKAGNNMLLVGVHGPRTPCEEILVKHVGSRL 2639
                S+V A+G GL +A+  +   FTV    AG   L + V GP     +I  +      
Sbjct: 1325 GCQPSRVQAQGPGLKEAFTNKPNVFTVVTRGAGIGGLGITVEGPSE--SKINCRDNKDGS 1382

Query: 2640 YSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLVP*ALCPGQ 2762
             S  Y+    G+Y + + +G  HIPGSP+RV V   + P +
Sbjct: 1383 CSAEYIPFAPGDYDVNITYGGAHIPGSPFRVPVKDVVDPSK 1423



 Score =  273 bits (699), Expect = 3e-73
 Identities = 244/893 (27%), Positives = 379/893 (42%), Gaps = 48/893 (5%)
 Frame = +3

Query: 204  GEITGEVRMPSGKVAQPAITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFYVD 383
            GE+   V+ P G           DG  +  Y PS  G + + I +   HIP SP +  V 
Sbjct: 485  GELGVTVKGPKGLEELVKQKGFLDGVYSFEYYPSTPGKYSIAIMWGGHHIPKSPFEVQVG 544

Query: 384  -YVNCGHVTAYGPGLSHGVVNKPAVFTVNTKDAGEGGLSLAIEGPSKAEISCTDNQDGTC 560
                   V A+GPGL  G+V + A F V +  +  G L  AIEGPS+A+I   D  DG+C
Sbjct: 545  PEAGMQKVRAWGPGLHGGIVGRSADFVVESIGSEVGSLGFAIEGPSQAKIEYDDQNDGSC 604

Query: 561  SVSYLPVLPGDYSILVKYNEQHIPGSPFTARV---TGD----------DSMRMSHLKVGS 701
             V Y P  PG+Y++ +  +++ I  SP+ A +   +GD            +  S   V +
Sbjct: 605  DVKYWPKEPGEYAVHIMCDDEDIKDSPYMAFIHPASGDYNPDLVQAYGPGLEKSGCIVDN 664

Query: 702  AADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNG 881
             A+  ++      + L        G+     +K   +G    S+ P +  +H + V   G
Sbjct: 665  LAEFTVDPKNAGKAPLKILAQDGEGQPIDIQMKSRMDGTYACSYTPVKPIKHTIAVVWGG 724

Query: 882  QHVASSPIPVVISQSEIGDASRVRVSGRGLHEG--HTFEPAEFIIDTRDAGYGGLSLSIE 1055
             ++ +SP  V I Q       +V+V G G+        EP  F +D  +AG G +S+ I+
Sbjct: 725  VNIPNSPYRVNIGQG--SHPQKVKVFGPGVERSGLKANEPTHFTVDCTEAGEGDVSVGIK 782

Query: 1056 GPSKVDINTEDLED----------GTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVT 1205
              ++V   +ED ED           T  V Y P   G Y I + FA Q +P SPF V+V 
Sbjct: 783  CDARV--LSEDEEDVDFDIIHNANDTFTVKYVPPAAGRYTIKVLFASQEIPASPFRVRVD 840

Query: 1206 GEGRVKESITRRQRAPSVANVG------SHCDLSLKIPEISIQDMTAQVTSPSGKSHEAE 1367
                  ++   +   P ++  G      +H  +  K    +  ++      P     + +
Sbjct: 841  PS---HDASKVKAEGPGLSKSGVENGKPTHFTVYTKGAGKAPLNVQFSSPLPGDAVKDLD 897

Query: 1368 IVEGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLE 1547
            +++  ++++ +++ P + G   V V Y G  +P SPF   V    +    KV     GLE
Sbjct: 898  VIDNYDYSHTVKYTPTQQGTMHVLVTYGGDPIPESPFTVAVAAPLDLSRIKVN----GLE 953

Query: 1548 -RAEAGVPAEFSIWTREAGA-GGLAIAVEGPSK-------AEISFEDRKDGSCGVAYVVQ 1700
             R E G   EF+I TR AG  G L + +  PS+       A ++  +    S    ++ +
Sbjct: 954  NRVEVGKDQEFAIDTRGAGGQGKLDVTILSPSRKVVPCLVAPVAGRE----SSTAKFIPR 1009

Query: 1701 EPGDYEVSVKFNEEHIPDSPFVVPVASPSGDARRLTVSSLQESGLKVNQPASFAVSLNGA 1880
            E G Y V V ++   +P SP++V  + P    +        E GL V +PA F +   GA
Sbjct: 1010 EEGLYAVDVTYDGHPVPGSPYMVEASLPPDPTKVKAHGPGLEGGL-VGKPAEFTIDTKGA 1068

Query: 1881 -KGAIDAKVHSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIR 2057
              G +   V  P  A  EC  ++      +V ++P + G Y +++ F   HIPGSPFK  
Sbjct: 1069 GTGGLGLTVEGPCEAKIEC--SDNGDGTCSVSYLPTKPGEYFVNILFEEVHIPGSPFKAD 1126

Query: 2058 VGEPGHGGDPGLVSAYGAGLEGGVTGSPAEFIVNTSNAGAGALSV--TIDGPSKVKMDCQ 2231
            +  P    DP  V A G GLE G  G      V+ S AG G L +    D  +K ++  +
Sbjct: 1127 IEMP---FDPSKVVASGPGLEHGKVGEAGLLSVDCSEAGPGTLGLEAVSDSGAKAEVCIE 1183

Query: 2232 ECPEG-YRVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHSLHETSSVFVD 2408
               +G Y VTY P+  G Y +++KYGG        F ARV     V      +TS V   
Sbjct: 1184 NNKDGTYAVTYVPLTAGMYTLTMKYGGEL---VPHFPARVKVEPAV------DTSRV--- 1231

Query: 2409 SLTKTXXXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVD---CSKAGNNMLLVG 2579
                                  KV   G+     +      FTVD    ++ G + +   
Sbjct: 1232 ----------------------KVFGPGIEGKDVFREATTDFTVDSRPLTQVGGDHIKAH 1269

Query: 2580 VHGPRTPCEEILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLV 2738
            +  P     E  V       Y V Y   +KG + + V + D  IP SP++V V
Sbjct: 1270 IANPSGASTECFVTDNADGTYQVEYTPFEKGLHVVEVTYDDVPIPNSPFKVAV 1322



 Score =  231 bits (590), Expect = 1e-60
 Identities = 231/840 (27%), Positives = 365/840 (43%), Gaps = 47/840 (5%)
 Frame = +3

Query: 354  PGSPLQFYVDYVNCGHVTAYGPGL--SHGVVNKPAVFTVNTKDAGEGGLSLAIEGP---- 515
            PG+PL+     +N     AYG G+  +  +V +PA FTV+T  AG+G + + +E P    
Sbjct: 244  PGAPLK---PKLNPKKARAYGRGIEPTGNMVKQPAKFTVDTISAGQGDVMVFVEDPEGNK 300

Query: 516  SKAEISCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARV--TGDDSMRMSHL 689
             +A ++   +++ T SV YLP + G + + V +  QHI  SPF   V     D+ +++  
Sbjct: 301  EEAHVTPDSDKNKTYSVEYLPKVTGLHKVTVLFAGQHISKSPFEVNVDKAQGDASKVTAK 360

Query: 690  KVGSAADIPINISETDLSLLTA---------TVVPPSGREEPCLLKRLRNGHV-GISFVP 839
              G  A   I    T   + TA          V  P G+    LL   +   V    + P
Sbjct: 361  GPGLEASGNIANKPTYFDIYTAGAGVGDIGVEVEDPQGKNTVELLVEDKGNQVYRCVYKP 420

Query: 840  KETGEHLVHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEG--HTFEPAEFIID 1013
             + G H++ V   G  +  SP   V+   E  + +  R SGRGL        E A+F +D
Sbjct: 421  MQPGPHVIKVSFAGDTIPKSPF--VVQVGEACNPNACRASGRGLQPKGIRIRETADFKVD 478

Query: 1014 TRDAGYGGLSLSIEGPSKVD--INTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSP 1187
            T+ AG G L ++++GP  ++  +  +   DG     Y P+ PG Y I I +   H+P SP
Sbjct: 479  TKAAGSGELGVTVKGPKGLEELVKQKGFLDGVYSFEYYPSTPGKYSIAIMWGGHHIPKSP 538

Query: 1188 FSVKVTGEGRVKESITRRQRAPSVAN--VGSHCDLSLKIPEISIQDMTAQVTSPSGKSHE 1361
            F V+V  E  +++    R   P +    VG   D  ++     +  +   +  PS    E
Sbjct: 539  FEVQVGPEAGMQKV---RAWGPGLHGGIVGRSADFVVESIGSEVGSLGFAIEGPSQAKIE 595

Query: 1362 AEIVEGENHTYC-IRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPL-GEGGAHKVRAGG 1535
                + +N   C +++ P E G + V +    + +  SP+   + P  G+     V+A G
Sbjct: 596  ---YDDQNDGSCDVKYWPKEPGEYAVHIMCDDEDIKDSPYMAFIHPASGDYNPDLVQAYG 652

Query: 1536 PGLERAEAGVP--AEFSIWTREAGAGGLAI-AVEGPSK-AEISFEDRKDGSCGVAYVVQE 1703
            PGLE++   V   AEF++  + AG   L I A +G  +  +I  + R DG+   +Y   +
Sbjct: 653  PGLEKSGCIVDNLAEFTVDPKNAGKAPLKILAQDGEGQPIDIQMKSRMDGTYACSYTPVK 712

Query: 1704 PGDYEVSVKFNEEHIPDSPFVVPVASPSGDAR-RLTVSSLQESGLKVNQPASFAVSLNGA 1880
            P  + ++V +   +IP+SP+ V +   S   + ++    ++ SGLK N+P  F V    A
Sbjct: 713  PIKHTIAVVWGGVNIPNSPYRVNIGQGSHPQKVKVFGPGVERSGLKANEPTHFTVDCTEA 772

Query: 1881 -KGAI------DAKVHSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPG 2039
             +G +      DA+V S      +  +     D + V+++P   G Y I V F    IP 
Sbjct: 773  GEGDVSVGIKCDARVLSEDEEDVDFDIIHNANDTFTVKYVPPAAGRYTIKVLFASQEIPA 832

Query: 2040 SPFKIRVGEPGHGGDPGLVSAYGAGL--EGGVTGSPAEFIVNTSNAGAGALSVTIDGP-- 2207
            SPF++RV +P H  D   V A G GL   G   G P  F V T  AG   L+V    P  
Sbjct: 833  SPFRVRV-DPSH--DASKVKAEGPGLSKSGVENGKPTHFTVYTKGAGKAPLNVQFSSPLP 889

Query: 2208 -SKVK-MD-CQECPEGYRVTYTPMAPGSYLISIKYGGPYHIGGSPFKARVTGHRLVSNHS 2378
               VK +D        + V YTP   G+  + + YGG   I  SPF   V          
Sbjct: 890  GDAVKDLDVIDNYDYSHTVKYTPTQQGTMHVLVTYGGD-PIPESPFTVAVAA-------- 940

Query: 2379 LHETSSVFVDSLTKTXXXXXXXXXXXXXXXXSKVLAKGLGLSKAYVGQKGSFTVDCSKA- 2555
                                           S++   GL  ++  VG+   F +D   A 
Sbjct: 941  ---------------------------PLDLSRIKVNGLE-NRVEVGKDQEFAIDTRGAG 972

Query: 2556 GNNMLLVGVHGPRTPCEEILVKHVGSRLYSVS-YLLKDKGEYTLVVKWGDEHIPGSPYRV 2732
            G   L V +  P       LV  V  R  S + ++ +++G Y + V +    +PGSPY V
Sbjct: 973  GQGKLDVTILSPSRKVVPCLVAPVAGRESSTAKFIPREEGLYAVDVTYDGHPVPGSPYMV 1032



 Score =  228 bits (581), Expect = 2e-59
 Identities = 191/707 (27%), Positives = 305/707 (43%), Gaps = 78/707 (11%)
 Frame = +3

Query: 204  GEITGEVRMPSGKVAQPAITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFYVD 383
            G +  E    SG  A+  I +NKDGT  V Y P  AG++ + ++Y    +P  P +  V+
Sbjct: 1164 GTLGLEAVSDSGAKAEVCIENNKDGTYAVTYVPLTAGMYTLTMKYGGELVPHFPARVKVE 1223

Query: 384  -YVNCGHVTAYGPGLSHGVVNKPAV--FTVNTKDAGEGG---LSLAIEGPSKAEISC--T 539
              V+   V  +GPG+    V + A   FTV+++   + G   +   I  PS A   C  T
Sbjct: 1224 PAVDTSRVKVFGPGIEGKDVFREATTDFTVDSRPLTQVGGDHIKAHIANPSGASTECFVT 1283

Query: 540  DNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARVT-GDDSMRMSHLKVGSAADIP 716
            DN DGT  V Y P   G + + V Y++  IP SPF   VT G    R+     G      
Sbjct: 1284 DNADGTYQVEYTPFEKGLHVVEVTYDDVPIPNSPFKVAVTEGCQPSRVQAQGPGLKEAFT 1343

Query: 717  -------INISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKK 875
                   +      +  L  TV  PS  +  C  +  ++G     ++P   G++ V++  
Sbjct: 1344 NKPNVFTVVTRGAGIGGLGITVEGPSESKINC--RDNKDGSCSAEYIPFAPGDYDVNITY 1401

Query: 876  NGQHVASSPIPVVISQSEIGDASRVRVSGRGLHEGHTFEPAE-FIIDTRDAGYGGLSLSI 1052
             G H+  SP  V +   ++ D S+V+++G GL  G      + F +D+  AG   L + +
Sbjct: 1402 GGAHIPGSPFRVPVK--DVVDPSKVKIAGPGLGSGVRARILQSFTVDSSKAGLAPLEVRV 1459

Query: 1053 EGPSKVD---------------------------------INTEDLEDGTCRVTYCPTEP 1133
             GP  V+                                 +N  D  DGT  VTY P++ 
Sbjct: 1460 LGPRAVETDSQSRRSPLKAISEFFKRDLKGDFMETGLVEPVNVVDNGDGTHTVTYTPSQE 1519

Query: 1134 GNYIINIKFADQHVPGSPFSVKVTGEGRVKESITRRQRAPSVANVGSHCDLSLKIPEISI 1313
            G Y++++K+AD+ +P SPF VKV       ++       P ++  G    L ++   I  
Sbjct: 1520 GPYMVSVKYADEEIPRSPFKVKVLP---TYDASKVTASGPGLSTYGVPASLPVEFA-IDA 1575

Query: 1314 QD-----MTAQVTSPSGKSHEAEIVEGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPF 1478
            +D     +  Q+T   GK   A + + ++ TY + ++P + G + + V Y G  +P SP+
Sbjct: 1576 RDAGEGLLAVQITDQEGKPKRAIVHDNKDGTYAVTYIPDKTGRYMIGVTYGGDDIPLSPY 1635

Query: 1479 QFTVGPLGEGGAHKVRAGGPGL-ERAEAGVPAEFSIWTREAGAGGLAIAVEGP--SKAEI 1649
            +      G+  A K  A GPG+    + G    F +  + AG G +   V  P  ++AE 
Sbjct: 1636 RIRATQTGD--ASKCLATGPGIASTVKTGEEVGFVVDAKTAGKGKVTCTVLTPDGTEAEA 1693

Query: 1650 SFEDRKDGSCGVAYVVQEPGDYEVSVKFNEEHIPDSPFVV-------------PV-ASPS 1787
               + +DG+  + Y   +PG Y + V+F    IP+SPF V             PV A P 
Sbjct: 1694 DVIENEDGTYDIFYTAAKPGTYVIYVRFGGVDIPNSPFTVMATDGEVAAVEEAPVNACPP 1753

Query: 1788 G------DARRLTVSSLQESGLKVNQPASFAVSLNGAKGAIDAKVHSPSGALEECYVTEI 1949
            G      +   + VS +   G K   P    +     KG I  +VH PSG      + + 
Sbjct: 1754 GFRPWVTEEAYVPVSDMNGLGFK---PFDLVIPFAVRKGEITGEVHMPSGKTATPEIVDN 1810

Query: 1950 DQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPG 2090
                  VR+ P E G++ + +K+ G+HIP      R  +PG     G
Sbjct: 1811 KDGTVTVRYAPTEVGLHEMHIKYMGSHIPD-----RTQQPGSSAGAG 1852



 Score =  142 bits (359), Expect = 9e-34
 Identities = 133/445 (29%), Positives = 193/445 (43%), Gaps = 15/445 (3%)
 Frame = +3

Query: 1449 KGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLERAEAGV--PAEFSIWTREAGAGGLAIA 1622
            K +  PG+P +  + P       K RA G G+E     V  PA+F++ T  AG G + + 
Sbjct: 239  KAKLKPGAPLKPKLNP------KKARAYGRGIEPTGNMVKQPAKFTVDTISAGQGDVMVF 292

Query: 1623 VEGPS----KAEISFEDRKDGSCGVAYVVQEPGDYEVSVKFNEEHIPDSPFVVPVASPSG 1790
            VE P     +A ++ +  K+ +  V Y+ +  G ++V+V F  +HI  SPF V V    G
Sbjct: 293  VEDPEGNKEEAHVTPDSDKNKTYSVEYLPKVTGLHKVTVLFAGQHISKSPFEVNVDKAQG 352

Query: 1791 DARRLTVS--SLQESGLKVNQPASFAVSLNGA-KGAIDAKVHSPSGA-LEECYVTEIDQD 1958
            DA ++T     L+ SG   N+P  F +   GA  G I  +V  P G    E  V +    
Sbjct: 353  DASKVTAKGPGLEASGNIANKPTYFDIYTAGAGVGDIGVEVEDPQGKNTVELLVEDKGNQ 412

Query: 1959 KYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPGLVSAYGAGLE--GGVT 2132
             Y   + P + G ++I V F G  IP SPF ++VGE     +P    A G GL+  G   
Sbjct: 413  VYRCVYKPMQPGPHVIKVSFAGDTIPKSPFVVQVGE---ACNPNACRASGRGLQPKGIRI 469

Query: 2133 GSPAEFIVNTSNAGAGALSVTIDGPSKVKMDCQE---CPEGYRVTYTPMAPGSYLISIKY 2303
               A+F V+T  AG+G L VT+ GP  ++   ++       Y   Y P  PG Y I+I +
Sbjct: 470  RETADFKVDTKAAGSGELGVTVKGPKGLEELVKQKGFLDGVYSFEYYPSTPGKYSIAIMW 529

Query: 2304 GGPYHIGGSPFKARVTGHRLVSNHSLHETSSVFVDSLTKTXXXXXXXXXXXXXXXXSKVL 2483
            GG +HI  SPF+ +V                                          KV 
Sbjct: 530  GG-HHIPKSPFEVQV-----------------------------------GPEAGMQKVR 553

Query: 2484 AKGLGLSKAYVGQKGSFTVDCSKAGNNMLLVGVHGPRTPCEEILVKHVGSRLYSVSYLLK 2663
            A G GL    VG+   F V+   +    L   + GP     E   ++ GS    V Y  K
Sbjct: 554  AWGPGLHGGIVGRSADFVVESIGSEVGSLGFAIEGPSQAKIEYDDQNDGS--CDVKYWPK 611

Query: 2664 DKGEYTLVVKWGDEHIPGSPYRVLV 2738
            + GEY + +   DE I  SPY   +
Sbjct: 612  EPGEYAVHIMCDDEDIKDSPYMAFI 636



 Score =  113 bits (283), Expect = 6e-25
 Identities = 53/86 (61%), Positives = 62/86 (72%)
 Frame = +3

Query: 99   GQQTWAPERPLVGVNGLDVTSLRPFDLVIPFTIKKGEITGEVRMPSGKVAQPAITDNKDG 278
            G + W  E   V V+ ++    +PFDLVIPF ++KGEITGEV MPSGK A P I DNKDG
Sbjct: 1754 GFRPWVTEEAYVPVSDMNGLGFKPFDLVIPFAVRKGEITGEVHMPSGKTATPEIVDNKDG 1813

Query: 279  TVTVRYAPSEAGLHEMDIRYDNMHIP 356
            TVTVRYAP+E GLHEM I+Y   HIP
Sbjct: 1814 TVTVRYAPTEVGLHEMHIKYMGSHIP 1839



 Score = 97.1 bits (240), Expect = 5e-20
 Identities = 74/275 (26%), Positives = 118/275 (42%), Gaps = 34/275 (12%)
 Frame = +3

Query: 168  PFDLVIPFTIK-----KGEITGEVRMPSGKVAQPAITDNKDGTVTVRYAPSEAGLHEMDI 332
            P  L + F I      +G +  ++    GK  +  + DNKDGT  V Y P + G + + +
Sbjct: 1564 PASLPVEFAIDARDAGEGLLAVQITDQEGKPKRAIVHDNKDGTYAVTYIPDKTGRYMIGV 1623

Query: 333  RYDNMHIPGSPLQFYVDYV-NCGHVTAYGPGLSHGVVNKPAV-FTVNTKDAGEGGLSLAI 506
             Y    IP SP +       +     A GPG++  V     V F V+ K AG+G ++  +
Sbjct: 1624 TYGGDDIPLSPYRIRATQTGDASKCLATGPGIASTVKTGEEVGFVVDAKTAGKGKVTCTV 1683

Query: 507  EGP--SKAEISCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARVTGDDSMRM 680
              P  ++AE    +N+DGT  + Y    PG Y I V++    IP SPFT   T  +   +
Sbjct: 1684 LTPDGTEAEADVIENEDGTYDIFYTAAKPGTYVIYVRFGGVDIPNSPFTVMATDGEVAAV 1743

Query: 681  SHLKVGSA-----------ADIPIN------ISETDLSL--------LTATVVPPSGREE 785
                V +            A +P++          DL +        +T  V  PSG+  
Sbjct: 1744 EEAPVNACPPGFRPWVTEEAYVPVSDMNGLGFKPFDLVIPFAVRKGEITGEVHMPSGKTA 1803

Query: 786  PCLLKRLRNGHVGISFVPKETGEHLVHVKKNGQHV 890
               +   ++G V + + P E G H +H+K  G H+
Sbjct: 1804 TPEIVDNKDGTVTVRYAPTEVGLHEMHIKYMGSHI 1838



 Score = 59.7 bits (143), Expect = 9e-09
 Identities = 46/167 (27%), Positives = 71/167 (42%), Gaps = 20/167 (11%)
 Frame = +3

Query: 192  TIKKGEITGEVRMPSGKVAQPAITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQ 371
            T  KG++T  V  P G  A+  + +N+DGT  + Y  ++ G + + +R+  + IP SP  
Sbjct: 1673 TAGKGKVTCTVLTPDGTEAEADVIENEDGTYDIFYTAAKPGTYVIYVRFGGVDIPNSPFT 1732

Query: 372  FY-----VDYVNCGHVTAYGPGLSHGVVNKPAVFTVNTKDAG-------------EGGLS 497
                   V  V    V A  PG    V  +  V   +    G             +G ++
Sbjct: 1733 VMATDGEVAAVEEAPVNACPPGFRPWVTEEAYVPVSDMNGLGFKPFDLVIPFAVRKGEIT 1792

Query: 498  LAIEGPS--KAEISCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIP 632
              +  PS   A     DN+DGT +V Y P   G + + +KY   HIP
Sbjct: 1793 GEVHMPSGKTATPEIVDNKDGTVTVRYAPTEVGLHEMHIKYMGSHIP 1839


>ref|XP_003362207.1| PREDICTED: filamin-A, partial [Sus scrofa].
          Length = 249

 Score =  310 bits (795), Expect = 2e-84
 Identities = 164/210 (78%), Positives = 164/210 (78%), Gaps = 21/210 (10%)
 Frame = +3

Query: 1857 FAVSLNGAKGAIDAKVHSPSGALEECYVTEIDQ---------------------DKYAVR 1973
            F VSLNGAKGAIDAKVHSPSGALEECYVTEIDQ                     DKYAVR
Sbjct: 44   FGVSLNGAKGAIDAKVHSPSGALEECYVTEIDQGAACSVQEEGSQAHGALLCSSDKYAVR 103

Query: 1974 FIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPGLVSAYGAGLEGGVTGSPAEFI 2153
            FIPRENGVYLIDVKFNGTH     FKIRVGEPGHGGDPGLVSAYGAGLEGGVTG    FI
Sbjct: 104  FIPRENGVYLIDVKFNGTHXXXXXFKIRVGEPGHGGDPGLVSAYGAGLEGGVTGGSVAFI 163

Query: 2154 VNTSNAGAGALSVTIDGPSKVKMDCQECPEGYRVTYTPMAPGSYLISIKYGGPYHIGGSP 2333
            VNTSNAGAGALSVTIDGPSKVKMDCQECPEGYRVTYTPMAPGSYLISIK           
Sbjct: 164  VNTSNAGAGALSVTIDGPSKVKMDCQECPEGYRVTYTPMAPGSYLISIK----------- 212

Query: 2334 FKARVTGHRLVSNHSLHETSSVFVDSLTKT 2423
                VTGHRLVSNHSLHETSSVFVDSLTKT
Sbjct: 213  ----VTGHRLVSNHSLHETSSVFVDSLTKT 238



 Score = 97.4 bits (241), Expect = 4e-20
 Identities = 73/255 (28%), Positives = 116/255 (45%), Gaps = 1/255 (0%)
 Frame = +3

Query: 1062 SKVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTGEGRVKESITRR 1241
            S+VD++  + EDGT    Y   +PG Y+I ++F           V + G    K +I  +
Sbjct: 12   SEVDVDVVENEDGTFDSFYTAPQPGKYVICVRFG----------VSLNG---AKGAIDAK 58

Query: 1242 QRAPSVANVGSHCDLSLKIPEISIQDMTAQVTSPSGKSHEAEIVEGENHTYCIRFVPAEM 1421
              +PS A    +      + EI  Q     V     ++H A +   +   Y +RF+P E 
Sbjct: 59   VHSPSGALEECY------VTEID-QGAACSVQEEGSQAHGALLCSSDK--YAVRFIPREN 109

Query: 1422 GMHTVSVKYKGQHVPGSPFQFTVGPLGEGG-AHKVRAGGPGLERAEAGVPAEFSIWTREA 1598
            G++ + VK+ G H     F+  VG  G GG    V A G GLE    G    F + T  A
Sbjct: 110  GVYLIDVKFNGTHXXXXXFKIRVGEPGHGGDPGLVSAYGAGLEGGVTGGSVAFIVNTSNA 169

Query: 1599 GAGGLAIAVEGPSKAEISFEDRKDGSCGVAYVVQEPGDYEVSVKFNEEHIPDSPFVVPVA 1778
            GAG L++ ++GPSK ++  ++  +G   V Y    PG Y +S+K     +  +  +   +
Sbjct: 170  GAGALSVTIDGPSKVKMDCQECPEG-YRVTYTPMAPGSYLISIKVTGHRLVSNHSLHETS 228

Query: 1779 SPSGDARRLTVSSLQ 1823
            S   D+   T S+ Q
Sbjct: 229  SVFVDSLTKTASAPQ 243



 Score = 91.3 bits (225), Expect = 3e-18
 Identities = 73/247 (29%), Positives = 114/247 (46%), Gaps = 1/247 (0%)
 Frame = +3

Query: 516  SKAEISCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARVTGDDSMRMSHLKV 695
            S+ ++   +N+DGT    Y    PG Y I V++             V+ + +      KV
Sbjct: 12   SEVDVDVVENEDGTFDSFYTAPQPGKYVICVRFG------------VSLNGAKGAIDAKV 59

Query: 696  GSAADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKK 875
             S +        T++    A  V   G +    L    +    + F+P+E G +L+ VK 
Sbjct: 60   HSPSGALEECYVTEIDQGAACSVQEEGSQAHGALL-CSSDKYAVRFIPRENGVYLIDVKF 118

Query: 876  NGQHVASSPIPVVISQ-SEIGDASRVRVSGRGLHEGHTFEPAEFIIDTRDAGYGGLSLSI 1052
            NG H       + + +    GD   V   G GL  G T     FI++T +AG G LS++I
Sbjct: 119  NGTHXXXXXFKIRVGEPGHGGDPGLVSAYGAGLEGGVTGGSVAFIVNTSNAGAGALSVTI 178

Query: 1053 EGPSKVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTGEGRVKESI 1232
            +GPSKV ++ ++  +G  RVTY P  PG+Y+I+IK    H   S  S+  T    V +S+
Sbjct: 179  DGPSKVKMDCQECPEG-YRVTYTPMAPGSYLISIKVTG-HRLVSNHSLHETSSVFV-DSL 235

Query: 1233 TRRQRAP 1253
            T+   AP
Sbjct: 236  TKTASAP 242



 Score = 79.3 bits (194), Expect = 1e-14
 Identities = 50/162 (30%), Positives = 75/162 (46%), Gaps = 25/162 (15%)
 Frame = +3

Query: 201 KGEITGEVRMPSGKVAQPAITDNKDGTV---------------------TVRYAPSEAGL 317
           KG I  +V  PSG + +  +T+   G                        VR+ P E G+
Sbjct: 52  KGAIDAKVHSPSGALEECYVTEIDQGAACSVQEEGSQAHGALLCSSDKYAVRFIPRENGV 111

Query: 318 HEMDIRYDNMHIPGSPLQFYVDYVNCGH----VTAYGPGLSHGVVNKPAVFTVNTKDAGE 485
           + +D++++  H      +  V     G     V+AYG GL  GV      F VNT +AG 
Sbjct: 112 YLIDVKFNGTHXXXXXFKIRVGEPGHGGDPGLVSAYGAGLEGGVTGGSVAFIVNTSNAGA 171

Query: 486 GGLSLAIEGPSKAEISCTDNQDGTCSVSYLPVLPGDYSILVK 611
           G LS+ I+GPSK ++ C +  +G   V+Y P+ PG Y I +K
Sbjct: 172 GALSVTIDGPSKVKMDCQECPEG-YRVTYTPMAPGSYLISIK 212



 Score = 53.5 bits (127), Expect = 7e-07
 Identities = 55/238 (23%), Positives = 86/238 (36%), Gaps = 3/238 (1%)
 Frame = +3

Query: 1320 MTAQVTSPSGKSHEAEIVEGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPL 1499
            +T  V +P G   + ++VE E+ T+   +   + G + + V+            F V   
Sbjct: 2    VTCTVCTPDGSEVDVDVVENEDGTFDSFYTAPQPGKYVICVR------------FGVSLN 49

Query: 1500 GEGGAHKVRAGGPGLERAEAGVPAEFSIWTREAGAGGLAIAVEGPSKAEISFEDRKDGSC 1679
            G  GA   +   P     E         +  E   G      E  S+A  +     D   
Sbjct: 50   GAKGAIDAKVHSPSGALEEC--------YVTEIDQGAACSVQEEGSQAHGALLCSSD-KY 100

Query: 1680 GVAYVVQEPGDYEVSVKFNEEHIPDSPFVVPVASPSGDARRLTVSSL---QESGLKVNQP 1850
             V ++ +E G Y + VKFN  H     F + V  P        VS+     E G+     
Sbjct: 101  AVRFIPRENGVYLIDVKFNGTHXXXXXFKIRVGEPGHGGDPGLVSAYGAGLEGGVTGGSV 160

Query: 1851 ASFAVSLNGAKGAIDAKVHSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNG 2024
            A    + N   GA+   +  PS    +C   +   + Y V + P   G YLI +K  G
Sbjct: 161  AFIVNTSNAGAGALSVTIDGPSKVKMDC---QECPEGYRVTYTPMAPGSYLISIKVTG 215


>ref|XP_003361471.1| PREDICTED: tripartite motif-containing protein 45-like isoform 1
           [Sus scrofa].
          Length = 580

 Score = 53.5 bits (127), Expect = 7e-07
 Identities = 34/92 (36%), Positives = 46/92 (50%), Gaps = 11/92 (11%)
 Frame = +3

Query: 414 GPGLSHGVVNKPAVFTVNTKDA-----GEGGLSLAI------EGPSKAEISCTDNQDGTC 560
           G  L      + A FT+  KDA     G GG ++ +      +  S  +    DN+DGT 
Sbjct: 406 GEDLHRAREKQTASFTLLCKDAAGENMGRGGDNIQVAVVPKDKKNSPVKTMVHDNKDGTY 465

Query: 561 SVSYLPVLPGDYSILVKYNEQHIPGSPFTARV 656
            +SY P  PG Y++LV   EQH+ GSPFT  V
Sbjct: 466 CISYTPKEPGVYTVLVCIKEQHVQGSPFTVTV 497



 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 32/100 (32%), Positives = 49/100 (49%), Gaps = 11/100 (11%)
 Frame = +3

Query: 936  DASRVRVSGRGLHEGHTFEPAEFIIDTRDA-----GYGGLSLSI------EGPSKVDINT 1082
            D ++  + G  LH     + A F +  +DA     G GG ++ +      +  S V    
Sbjct: 398  DPAKCVLQGEDLHRAREKQTASFTLLCKDAAGENMGRGGDNIQVAVVPKDKKNSPVKTMV 457

Query: 1083 EDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKV 1202
             D +DGT  ++Y P EPG Y + +   +QHV GSPF+V V
Sbjct: 458  HDNKDGTYCISYTPKEPGVYTVLVCIKEQHVQGSPFTVTV 497


>ref|XP_001929378.1| PREDICTED: tripartite motif-containing protein 45-like isoform 1
           [Sus scrofa].
          Length = 580

 Score = 53.5 bits (127), Expect = 7e-07
 Identities = 34/92 (36%), Positives = 46/92 (50%), Gaps = 11/92 (11%)
 Frame = +3

Query: 414 GPGLSHGVVNKPAVFTVNTKDA-----GEGGLSLAI------EGPSKAEISCTDNQDGTC 560
           G  L      + A FT+  KDA     G GG ++ +      +  S  +    DN+DGT 
Sbjct: 406 GEDLHRAREKQTASFTLLCKDAAGENMGRGGDNIQVAVVPKDKKNSPVKTMVHDNKDGTY 465

Query: 561 SVSYLPVLPGDYSILVKYNEQHIPGSPFTARV 656
            +SY P  PG Y++LV   EQH+ GSPFT  V
Sbjct: 466 CISYTPKEPGVYTVLVCIKEQHVQGSPFTVTV 497



 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 32/100 (32%), Positives = 49/100 (49%), Gaps = 11/100 (11%)
 Frame = +3

Query: 936  DASRVRVSGRGLHEGHTFEPAEFIIDTRDA-----GYGGLSLSI------EGPSKVDINT 1082
            D ++  + G  LH     + A F +  +DA     G GG ++ +      +  S V    
Sbjct: 398  DPAKCVLQGEDLHRAREKQTASFTLLCKDAAGENMGRGGDNIQVAVVPKDKKNSPVKTMV 457

Query: 1083 EDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKV 1202
             D +DGT  ++Y P EPG Y + +   +QHV GSPF+V V
Sbjct: 458  HDNKDGTYCISYTPKEPGVYTVLVCIKEQHVQGSPFTVTV 497


  Database: RefSeq49_SP.fasta
    Posted date:  Oct 17, 2011  1:42 PM
  Number of letters in database: 11,343,932
  Number of sequences in database:  24,897
  
Lambda     K      H
   0.318    0.134    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 24897
Number of Hits to DB: 80,846,961
Number of extensions: 2565249
Number of successful extensions: 16019
Number of sequences better than 1.0e-05: 12
Number of HSP's gapped: 14731
Number of HSP's successfully gapped: 140
Length of query: 1029
Length of database: 11,343,932
Length adjustment: 109
Effective length of query: 920
Effective length of database: 8,630,159
Effective search space: 7939746280
Effective search space used: 7939746280
Neighboring words threshold: 12
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 35 (18.1 bits)

BLASTN 2.2.24 [Aug-08-2010]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= 20110601C-007518
         (3088 letters)

Database: Sscrofa_10.2.fasta 
           4582 sequences; 2,808,509,378 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gb|GL896530.1| Sus scrofa unplaced genomic scaffold chrU_scaffol...   442   e-121
gb|GL896441.1| Sus scrofa unplaced genomic scaffold chrU_scaffol...   323   3e-85
gb|GL896067.1| Sus scrofa unplaced genomic scaffold chrU_scaffol...   281   1e-72
Sscrofa_Chr18                                                         137   4e-29
Sscrofa_Chr13                                                         127   4e-26
gb|GL896249.1| Sus scrofa unplaced genomic scaffold chrU_scaffol...   105   1e-19

>gb|GL896530.1| Sus scrofa unplaced genomic scaffold chrU_scaffold861
          Length = 3058

 Score =  442 bits (223), Expect = e-121
 Identities = 223/223 (100%)
 Strand = Plus / Plus

                                                                        
Query: 1302 gaaattagcatccaggacatgacagcccaggtgaccagcccatcaggcaagagccacgag 1361
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 2594 gaaattagcatccaggacatgacagcccaggtgaccagcccatcaggcaagagccacgag 2653

                                                                        
Query: 1362 gctgagatcgtggaaggggagaaccatacctactgcatccgcttcgtgcccgctgagatg 1421
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 2654 gctgagatcgtggaaggggagaaccatacctactgcatccgcttcgtgcccgctgagatg 2713

                                                                        
Query: 1422 ggcatgcacacggtcagcgtcaagtacaagggccagcacgtgcctgggagccctttccag 1481
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 2714 ggcatgcacacggtcagcgtcaagtacaagggccagcacgtgcctgggagccctttccag 2773

                                                       
Query: 1482 ttcaccgtggggcccctgggggaagggggcgcccacaaggtcc 1524
            |||||||||||||||||||||||||||||||||||||||||||
Sbjct: 2774 ttcaccgtggggcccctgggggaagggggcgcccacaaggtcc 2816



 Score =  351 bits (177), Expect = 1e-93
 Identities = 177/177 (100%)
 Strand = Plus / Plus

                                                                        
Query: 486  ggaggcttgtccctggccatcgaggggccatccaaagccgaaatcagctgcaccgacaac 545
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 975  ggaggcttgtccctggccatcgaggggccatccaaagccgaaatcagctgcaccgacaac 1034

                                                                        
Query: 546  caagatgggacgtgcagcgtctcctacctgcccgtgctgcctggcgactacagcatcctg 605
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 1035 caagatgggacgtgcagcgtctcctacctgcccgtgctgcctggcgactacagcatcctg 1094

                                                                     
Query: 606  gtcaagtacaacgagcagcacatcccaggcagccccttcacggccagggtcacaggt 662
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 1095 gtcaagtacaacgagcagcacatcccaggcagccccttcacggccagggtcacaggt 1151



 Score =  299 bits (151), Expect = 5e-78
 Identities = 151/151 (100%)
 Strand = Plus / Plus

                                                                        
Query: 1023 gcaggctacggtgggctcagcctgtccatcgagggtcccagcaaggtggacatcaacaca 1082
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 2001 gcaggctacggtgggctcagcctgtccatcgagggtcccagcaaggtggacatcaacaca 2060

                                                                        
Query: 1083 gaggacctggaggatggcacgtgcagggtcacctactgccccacggagccgggcaactac 1142
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 2061 gaggacctggaggatggcacgtgcagggtcacctactgccccacggagccgggcaactac 2120

                                           
Query: 1143 atcatcaacatcaagttcgccgaccaacacg 1173
            |||||||||||||||||||||||||||||||
Sbjct: 2121 atcatcaacatcaagttcgccgaccaacacg 2151



 Score =  246 bits (124), Expect = 6e-62
 Identities = 124/124 (100%)
 Strand = Plus / Plus

                                                                        
Query: 1179 ggcagcccgttctccgtgaaagtgaccggtgagggccgggtgaaagagagcatcacacgc 1238
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 2354 ggcagcccgttctccgtgaaagtgaccggtgagggccgggtgaaagagagcatcacacgc 2413

                                                                        
Query: 1239 aggcaacgggctccttcggtggctaatgtcggcagtcattgcgacctcagcctgaagatc 1298
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 2414 aggcaacgggctccttcggtggctaatgtcggcagtcattgcgacctcagcctgaagatc 2473

                
Query: 1299 cctg 1302
            ||||
Sbjct: 2474 cctg 2477



 Score =  234 bits (118), Expect = 2e-58
 Identities = 118/118 (100%)
 Strand = Plus / Plus

                                                                        
Query: 658  caggtgacgactcgatgcgcatgtcccacctgaaagtgggctctgccgccgacatcccca 717
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 1252 caggtgacgactcgatgcgcatgtcccacctgaaagtgggctctgccgccgacatcccca 1311

                                                                      
Query: 718  tcaatatctccgagacggacctcagcctgctgacagccacggtggtgccaccctcagg 775
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 1312 tcaatatctccgagacggacctcagcctgctgacagccacggtggtgccaccctcagg 1369



 Score =  206 bits (104), Expect = 5e-50
 Identities = 104/104 (100%)
 Strand = Plus / Plus

                                                                        
Query: 923  gtcggagatcggggatgccagccgcgtgcgggtctcgggccggggcctccacgaaggcca 982
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 1741 gtcggagatcggggatgccagccgcgtgcgggtctcgggccggggcctccacgaaggcca 1800

                                                        
Query: 983  cacctttgagcctgcagagtttatcattgacacccgtgatgcag 1026
            ||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 1801 cacctttgagcctgcagagtttatcattgacacccgtgatgcag 1844



 Score =  200 bits (101), Expect = 3e-48
 Identities = 101/101 (100%)
 Strand = Plus / Plus

                                                                       
Query: 117 ccagaaagacccttggtgggcgtcaacgggctggatgtgaccagcctgaggcccttcgac 176
           ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 191 ccagaaagacccttggtgggcgtcaacgggctggatgtgaccagcctgaggcccttcgac 250

                                                    
Query: 177 cttgtcatccccttcaccatcaagaagggcgaaatcactgg 217
           |||||||||||||||||||||||||||||||||||||||||
Sbjct: 251 cttgtcatccccttcaccatcaagaagggcgaaatcactgg 291



 Score =  131 bits (66), Expect = 3e-27
 Identities = 66/66 (100%)
 Strand = Plus / Plus

                                                                        
Query: 822  gggatctcgttcgtgcccaaggagacaggcgagcacctggtgcatgtgaagaagaatggc 881
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 1575 gggatctcgttcgtgcccaaggagacaggcgagcacctggtgcatgtgaagaagaatggc 1634

                  
Query: 882  cagcat 887
            ||||||
Sbjct: 1635 cagcat 1640



 Score =  117 bits (59), Expect = 4e-23
 Identities = 59/59 (100%)
 Strand = Plus / Plus

                                                                      
Query: 216 ggggaggtgcggatgccctcgggcaaggtggcgcagccagccatcaccgacaacaagga 274
           |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 380 ggggaggtgcggatgccctcgggcaaggtggcgcagccagccatcaccgacaacaagga 438



 Score = 95.6 bits (48), Expect = 1e-16
 Identities = 48/48 (100%)
 Strand = Plus / Plus

                                                           
Query: 440 gaacaagcctgctgtcttcaccgtcaacaccaaggatgcgggagaggg 487
           ||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 707 gaacaagcctgctgtcttcaccgtcaacaccaaggatgcgggagaggg 754


>gb|GL896441.1| Sus scrofa unplaced genomic scaffold chrU_scaffold781
          Length = 2648

 Score =  323 bits (163), Expect = 3e-85
 Identities = 163/163 (100%)
 Strand = Plus / Plus

                                                                        
Query: 2143 ccgagtttattgtgaacacgagcaatgcgggagccggtgccctgtcggtcaccatcgacg 2202
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 2171 ccgagtttattgtgaacacgagcaatgcgggagccggtgccctgtcggtcaccatcgacg 2230

                                                                        
Query: 2203 ggccctccaaggtgaagatggattgccaggagtgcccggagggctaccgcgtcacctaca 2262
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 2231 ggccctccaaggtgaagatggattgccaggagtgcccggagggctaccgcgtcacctaca 2290

                                                       
Query: 2263 cccccatggcacctggcagctacctcatctccatcaagtatgg 2305
            |||||||||||||||||||||||||||||||||||||||||||
Sbjct: 2291 cccccatggcacctggcagctacctcatctccatcaagtatgg 2333



 Score =  248 bits (125), Expect = 2e-62
 Identities = 125/125 (100%)
 Strand = Plus / Plus

                                                                        
Query: 1832 gctaaaggtcaaccagccagcctcttttgcagtcagcctgaatggggctaagggggcgat 1891
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 649  gctaaaggtcaaccagccagcctcttttgcagtcagcctgaatggggctaagggggcgat 708

                                                                        
Query: 1892 cgatgccaaggtgcacagcccctcgggagccctggaggagtgctatgtcacagagatcga 1951
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 709  cgatgccaaggtgcacagcccctcgggagccctggaggagtgctatgtcacagagatcga 768

                 
Query: 1952 ccaag 1956
            |||||
Sbjct: 769  ccaag 773



 Score =  228 bits (115), Expect = 1e-56
 Identities = 115/115 (100%)
 Strand = Plus / Plus

                                                                        
Query: 2352 ggtcaccgtctcgtcagcaaccacagcctccacgagacgtcgtcagtgtttgtggactcc 2411
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 2534 ggtcaccgtctcgtcagcaaccacagcctccacgagacgtcgtcagtgtttgtggactcc 2593

                                                                   
Query: 2412 ctgaccaagactgccagtgccccccagcatggggccccgggcccaggtgccgccg 2466
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 2594 ctgaccaagactgccagtgccccccagcatggggccccgggcccaggtgccgccg 2648



 Score =  178 bits (90), Expect = 1e-41
 Identities = 90/90 (100%)
 Strand = Plus / Plus

                                                                        
Query: 2045 cttcaagatccgagtcggggagcctgggcatggaggggacccaggcctggtgtccgctta 2104
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 1751 cttcaagatccgagtcggggagcctgggcatggaggggacccaggcctggtgtccgctta 1810

                                          
Query: 2105 cggagctggcctggaaggcggcgtcacagg 2134
            ||||||||||||||||||||||||||||||
Sbjct: 1811 cggagctggcctggaaggcggcgtcacagg 1840



 Score =  153 bits (77), Expect = 7e-34
 Identities = 77/77 (100%)
 Strand = Plus / Plus

                                                                        
Query: 1955 agataagtacgctgtgcgctttatcccacgagagaacggcgtctacctgattgatgtcaa 2014
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 1574 agataagtacgctgtgcgctttatcccacgagagaacggcgtctacctgattgatgtcaa 1633

                             
Query: 2015 gttcaatggcacccaca 2031
            |||||||||||||||||
Sbjct: 1634 gttcaatggcacccaca 1650


>gb|GL896067.1| Sus scrofa unplaced genomic scaffold chrU_scaffold457
          Length = 999

 Score =  281 bits (142), Expect = 1e-72
 Identities = 152/154 (98%), Gaps = 1/154 (0%)
 Strand = Plus / Minus

                                                                        
Query: 2883 ggccctgtgctgcgctcacctgcctccacttgggcaaaggagagaggcgagcagagggag 2942
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 607  ggccctgtgctgcgctcacctgcctccacttgggcaaaggagagaggcgagcagagggag 548

                                                                        
Query: 2943 ccatttggtggccctgcctgtcttctctggttctgggaggggtgagaggcggggggtctt 3002
            ||||||||||||||||||||||||||||||||||||||||||||||||||| ||||||||
Sbjct: 547  ccatttggtggccctgcctgtcttctctggttctgggaggggtgagaggcg-ggggtctt 489

                                              
Query: 3003 gtgcacacccactccctagtgcccttccctcgcc 3036
            |||||||||||||| |||||||||||||||||||
Sbjct: 488  gtgcacacccactcgctagtgcccttccctcgcc 455



 Score =  113 bits (57), Expect = 6e-22
 Identities = 57/57 (100%)
 Strand = Plus / Minus

                                                                     
Query: 2727 cgcgtcctggtgccctgagctctgtgccctggccagccagcagctcccaggatgaga 2783
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 843  cgcgtcctggtgccctgagctctgtgccctggccagccagcagctcccaggatgaga 787



 Score =  111 bits (56), Expect = 2e-21
 Identities = 56/56 (100%)
 Strand = Plus / Minus

                                                                    
Query: 2645 cgtctcctacctgctcaaggacaagggggagtacacgctggtggtcaaatggggcg 2700
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 999  cgtctcctacctgctcaaggacaagggggagtacacgctggtggtcaaatggggcg 944


>Sscrofa_Chr18 
||          Length = 61220071

 Score =  137 bits (69), Expect = 4e-29
 Identities = 126/145 (86%)
 Strand = Plus / Plus

                                                                            
Query: 1566     ccagctgagttcagcatctggaccagggaagctggcgccgggggcctggccattgctgtt 1625
                ||||| |||||||||||||||||| | |||||||| |||||||||||| | |||||||| 
Sbjct: 20878930 ccagccgagttcagcatctggacccgagaagctggtgccgggggcctgtctattgctgtg 20878989

                                                                            
Query: 1626     gagggccccagcaaggccgagatctccttcgaggaccgcaaggacggctcctgcggcgtg 1685
                ||||||||||||||||| |||||  | || ||||||||||| || ||||||||||| || 
Sbjct: 20878990 gagggccccagcaaggcagagattgcatttgaggaccgcaaagatggctcctgcggggtc 20879049

                                         
Query: 1686     gcctatgtggtccaggagccaggtg 1710
                 ||||||| |||||||| |||||||
Sbjct: 20879050 tcctatgtcgtccaggaaccaggtg 20879074



 Score =  121 bits (61), Expect = 2e-24
 Identities = 136/161 (84%)
 Strand = Plus / Plus

                                                                            
Query: 2190     gtcaccatcgacgggccctccaaggtgaagatggattgccaggagtgcccggagggctac 2249
                |||||||||||||| |||||||||||| || | || || | |||||| || |||||  ||
Sbjct: 20880696 gtcaccatcgacggcccctccaaggtgcagctagactgtcgggagtgtcctgaggggcac 20880755

                                                                            
Query: 2250     cgcgtcacctacacccccatggcacctggcagctacctcatctccatcaagtatggtggc 2309
                   || ||||| || |||||||| ||||||| |||||||||  |||||||||||||||||
Sbjct: 20880756 gtggttacctatactcccatggctcctggcaactacctcattgccatcaagtatggtggc 20880815

                                                         
Query: 2310     ccctaccacattgggggcagccccttcaaggccagagtcac 2350
                ||| | ||||||| |||||||||||||||||||| ||||||
Sbjct: 20880816 ccccagcacattgtgggcagccccttcaaggccaaagtcac 20880856



 Score =  109 bits (55), Expect = 9e-21
 Identities = 103/119 (86%)
 Strand = Plus / Plus

                                                                            
Query: 1062     agcaaggtggacatcaacacagaggacctggaggatggcacgtgcagggtcacctactgc 1121
                ||||||||||||||||||   |||||  ||||||||||||| ||||  ||||||||||||
Sbjct: 20877725 agcaaggtggacatcaactgtgaggatatggaggatggcacctgcaaagtcacctactgc 20877784

                                                                           
Query: 1122     cccacggagccgggcaactacatcatcaacatcaagttcgccgaccaacacgtgcctgg 1180
                ||||| || || |||| ||||||||||||||||||||| |||||| | ||||| |||||
Sbjct: 20877785 cccaccgaacccggcacctacatcatcaacatcaagtttgccgacaagcacgtacctgg 20877843



 Score =  105 bits (53), Expect = 1e-19
 Identities = 170/209 (81%)
 Strand = Plus / Plus

                                                                            
Query: 1314     caggacatgacagcccaggtgaccagcccatcaggcaagagccacgaggctgagatcgtg 1373
                ||||||||||| || |||||||||||||| ||||||||||   | |  || |||||||||
Sbjct: 20878586 caggacatgaccgcacaggtgaccagcccctcaggcaagacggaggccgcggagatcgtg 20878645

                                                                            
Query: 1374     gaaggggagaaccatacctactgcatccgcttcgtgcccgctgagatgggcatgcacacg 1433
                || |||||| ||    | ||| || | ||||||||||||   ||||||||    ||||||
Sbjct: 20878646 gagggggaggacagcgcgtacagcgtgcgcttcgtgccccaggagatggggccccacacg 20878705

                                                                            
Query: 1434     gtcagcgtcaagtacaagggccagcacgtgcctgggagccctttccagttcaccgtgggg 1493
                |||| ||||||||||   |||||||||||||| || ||||| || |||||||||||||||
Sbjct: 20878706 gtcaccgtcaagtaccgcggccagcacgtgccaggcagcccctttcagttcaccgtgggg 20878765

                                             
Query: 1494     cccctgggggaagggggcgcccacaaggt 1522
                || ||||| ||||| || |||||||||||
Sbjct: 20878766 ccactgggtgaaggtggtgcccacaaggt 20878794



 Score =  105 bits (53), Expect = 1e-19
 Identities = 71/77 (92%)
 Strand = Plus / Plus

                                                                            
Query: 1704     ccaggtgactacgaggtctccgtcaagttcaacgaggagcacatccctgacagccctttt 1763
                ||||||||||| ||||||||| |||||||||| || ||||||||||| |||||||| |||
Sbjct: 20879326 ccaggtgactatgaggtctccatcaagttcaatgatgagcacatcccggacagccccttt 20879385

                                 
Query: 1764     gtggtgcccgtggcctc 1780
                |||||||||||||||||
Sbjct: 20879386 gtggtgcccgtggcctc 20879402



 Score = 67.9 bits (34), Expect = 3e-08
 Identities = 70/82 (85%)
 Strand = Plus / Plus

                                                                            
Query: 1986     gagaacggcgtctacctgattgatgtcaagttcaatggcacccacatccctggaagcccc 2045
                |||||||||||| ||   || |||||||||||||| ||  |||||||||| || || |||
Sbjct: 20880385 gagaacggcgtccactccatcgatgtcaagttcaacggtgcccacatccccggcagtccc 20880444

                                      
Query: 2046     ttcaagatccgagtcggggagc 2067
                ||||||||||| ||||||||||
Sbjct: 20880445 ttcaagatccgcgtcggggagc 20880466



 Score = 60.0 bits (30), Expect = 8e-06
 Identities = 39/42 (92%)
 Strand = Plus / Plus

                                                          
Query: 622      agcacatcccaggcagccccttcacggccagggtcacaggtg 663
                ||||||||||||| |||||||||||||||| | |||||||||
Sbjct: 20876458 agcacatcccagggagccccttcacggccaagatcacaggtg 20876499


>Sscrofa_Chr13 
||          Length = 218635234

 Score =  127 bits (64), Expect = 4e-26
 Identities = 115/132 (87%)
 Strand = Plus / Minus

                                                                            
Query: 1416     gagatgggcatgcacacggtcagcgtcaagtacaagggccagcacgtgcctgggagccct 1475
                ||||||||| ||||||| ||||||||||| |||   |||||||||||  |||| ||||| 
Sbjct: 43891464 gagatgggcgtgcacactgtcagcgtcaaataccgtggccagcacgtcactggcagcccc 43891405

                                                                            
Query: 1476     ttccagttcaccgtggggcccctgggggaagggggcgcccacaaggtccgcgccgggggc 1535
                ||||||||||| |||||||| ||||| || |||||||||||||||||| | || ||||||
Sbjct: 43891404 ttccagttcactgtggggccgctgggcgaggggggcgcccacaaggtcagggcagggggc 43891345

                            
Query: 1536     cctggcctggag 1547
                ||||||||||||
Sbjct: 43891344 cctggcctggag 43891333



 Score =  115 bits (58), Expect = 1e-22
 Identities = 139/166 (83%)
 Strand = Plus / Minus

                                                                            
Query: 497      cctggccatcgaggggccatccaaagccgaaatcagctgcaccgacaaccaagatgggac 556
                |||||| || ||||| || || || ||||||||||||||||  |||||| ||||||||||
Sbjct: 43897280 cctggcaattgagggaccctcaaaggccgaaatcagctgcattgacaacaaagatgggac 43897221

                                                                            
Query: 557      gtgcagcgtctcctacctgcccgtgctgcctggcgactacagcatcctggtcaagtacaa 616
                |||||  ||  |||| ||||||   ||||| || ||||||||||| ||||||||||||||
Sbjct: 43897220 gtgcacagtgacctatctgcccaccctgccgggtgactacagcattctggtcaagtacaa 43897161

                                                              
Query: 617      cgagcagcacatcccaggcagccccttcacggccagggtcacaggt 662
                 ||  |||||||||| |||||||||||||| |||| | ||||||||
Sbjct: 43897160 tgacaagcacatccctggcagccccttcacagccaagatcacaggt 43897115



 Score = 83.8 bits (42), Expect = 5e-13
 Identities = 72/82 (87%)
 Strand = Plus / Minus

                                                                            
Query: 1567     cagctgagttcagcatctggaccagggaagctggcgccgggggcctggccattgctgttg 1626
                ||||||||||||||||||||||| |||| || |||||||| |||||  |||| ||||| |
Sbjct: 43890667 cagctgagttcagcatctggacccgggaggcaggcgccggaggcctctccatcgctgtcg 43890608

                                      
Query: 1627     agggccccagcaaggccgagat 1648
                |||||||||| ||||| |||||
Sbjct: 43890607 agggccccagtaaggctgagat 43890586



 Score = 71.9 bits (36), Expect = 2e-09
 Identities = 60/68 (88%)
 Strand = Plus / Minus

                                                                            
Query: 1059     cccagcaaggtggacatcaacacagaggacctggaggatggcacgtgcagggtcacctac 1118
                |||||||| ||||||||| | ||||||||||||||||| ||||| |||| |||| |||||
Sbjct: 43895148 cccagcaaagtggacatccagacagaggacctggaggacggcacttgcaaggtctcctac 43895089

                        
Query: 1119     tgccccac 1126
                | ||||||
Sbjct: 43895088 ttccccac 43895081


>gb|GL896249.1| Sus scrofa unplaced genomic scaffold chrU_scaffold608
          Length = 633

 Score =  105 bits (53), Expect = 1e-19
 Identities = 53/53 (100%)
 Strand = Plus / Minus

                                                                 
Query: 1704 ccaggtgactacgaggtctccgtcaagttcaacgaggagcacatccctgacag 1756
            |||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 406  ccaggtgactacgaggtctccgtcaagttcaacgaggagcacatccctgacag 354


  Database: Sscrofa_10.2.fasta
    Posted date:  Nov 16, 2011 10:34 AM
  Number of letters in database: 2,808,509,378
  Number of sequences in database:  4582
  
Lambda     K      H
    1.37    0.711     1.31 

Gapped
Lambda     K      H
    1.37    0.711     1.31 


Matrix: blastn matrix:1 -3
Gap Penalties: Existence: 5, Extension: 2
Number of Sequences: 4582
Number of Hits to DB: 69,612,883
Number of extensions: 422
Number of successful extensions: 422
Number of sequences better than 1.0e-05: 6
Number of HSP's gapped: 420
Number of HSP's successfully gapped: 30
Length of query: 3088
Length of database: 2,808,509,378
Length adjustment: 22
Effective length of query: 3066
Effective length of database: 2,808,408,574
Effective search space: 8610580687884
Effective search space used: 8610580687884
X1: 11 (21.8 bits)
X2: 15 (29.7 bits)
X3: 50 (99.1 bits)
S1: 18 (36.2 bits)
S2: 30 (60.0 bits)