Animal-Genome cDNA 20110601C-007684

BLASTX 2.2.24 [Aug-08-2010]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= 20110601C-007684
         (1055 letters)

Database: RefSeq49_BP.fasta 
           33,088 sequences; 17,681,374 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

Alignment   gi|NP_001069826.1| cAMP-dependent protein kinase type I-alpha r...   533   e-151
Alignment   gi|NP_001068669.1| protein kinase, cAMP-dependent, regulatory, ...   449   e-126
Alignment   gi|NP_001178296.1| cAMP-dependent protein kinase type II-alpha ...   162   6e-40
Alignment   gi|XP_002697092.1| PREDICTED: cAMP-dependent protein kinase, re...   162   6e-40
Alignment   gi|NP_777074.1| cAMP-dependent protein kinase type II-beta regu...   158   7e-39
Alignment   gi|XP_596590.3| PREDICTED: cAMP-dependent protein kinase, regul...   153   2e-37
Alignment   gi|NP_776861.1| cGMP-dependent protein kinase 1 [Bos taurus].        121   1e-27
Alignment   gi|NP_001137571.1| cGMP-dependent protein kinase 2 [Bos taurus].     110   2e-24
Alignment   gi|XP_002698219.1| PREDICTED: protein kinase, cAMP-dependent, r...    63   4e-10
Alignment   gi|NP_001073771.1| rap guanine nucleotide exchange factor 3 [Bo...    54   2e-07

>ref|NP_001069826.1| cAMP-dependent protein kinase type I-alpha regulatory subunit [Bos
            taurus].
          Length = 380

 Score =  533 bits (1373), Expect = e-151
 Identities = 271/288 (94%), Positives = 274/288 (95%)
 Frame = +2

Query: 146  MASGSTAXXXXXXXXXXXXYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKEE 325
            MASG+TA            YVQKHNIQALLKDSIVQLCTARPERPMAFLREYFE+LEKEE
Sbjct: 1    MASGTTASEEERSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFEKLEKEE 60

Query: 326  AKQIQNLQKASARADSREDEISPPPPNPVVKGRRRRGAISAEVYTEEDAASYVRKVIPKD 505
            AKQIQNLQKA +RADSREDEISPPPPNPVVKGRRRRGAISAEVYTEEDAASYVRKVIPKD
Sbjct: 61   AKQIQNLQKAGSRADSREDEISPPPPNPVVKGRRRRGAISAEVYTEEDAASYVRKVIPKD 120

Query: 506  YKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFPVSFIAGETVIQQGDEGDNFYVIDQGE 685
            YKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFPVSFIAGETVIQQGDEGDNFYVIDQGE
Sbjct: 121  YKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFPVSFIAGETVIQQGDEGDNFYVIDQGE 180

Query: 686  MDVYVNNEWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTLR 865
            MDVYVNNEWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTLR
Sbjct: 181  MDVYVNNEWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTLR 240

Query: 866  KRKMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEQG 1009
            KRKMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGE G
Sbjct: 241  KRKMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEPG 288



 Score = 69.7 bits (169), Expect = 4e-12
 Identities = 51/152 (33%), Positives = 76/152 (50%), Gaps = 9/152 (5%)
 Frame = +2

Query: 467 DAASYVRKVIPKDYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFPVSFIAGETVIQQG 646
           D  SY R ++    +      + + K  +   LD  ER  + DA+ PV F  G+ ++ QG
Sbjct: 226 DRDSYRRILMGSTLRKRKMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQG 285

Query: 647 DEGDNFYVIDQGEMDVY---VNNEWATSVGEGGS---FGELALIYGTPRAATVKAKTNVK 808
           + GD F++I +G   V      NE    VG  G    FGE+AL+   PRAATV A+  +K
Sbjct: 286 EPGDEFFIILEGSAAVLQRRSENEEFVEVGRLGPSDYFGEIALLMNRPRAATVVARGPLK 345

Query: 809 LWGIDRDSYRRIL-MGSTLRKR--KMYEEFLS 895
              +DR  + R+L   S + KR  + Y  F+S
Sbjct: 346 CVKLDRPRFERVLGPCSDILKRNIQQYNSFVS 377


>ref|NP_001068669.1| protein kinase, cAMP-dependent, regulatory, type I, beta [Bos
            taurus].
          Length = 381

 Score =  449 bits (1156), Expect = e-126
 Identities = 221/269 (82%), Positives = 245/269 (91%)
 Frame = +2

Query: 203  YVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKEEAKQIQNLQKASARADSRED 382
            YVQ+  IQ +LKD IVQLC A+PERPM FLRE+FERLEKEE +QI   QK+++++D +++
Sbjct: 21   YVQRRGIQQVLKDCIVQLCLAKPERPMRFLREHFERLEKEENRQILAQQKSASQSDLQDE 80

Query: 383  EISPPPPNPVVKGRRRRGAISAEVYTEEDAASYVRKVIPKDYKTMAALAKAIEKNVLFSH 562
            ++SP PPNPVVK R RRG +SAEVYTEEDA SYVRKVIPKDYKTM ALAKAI KNVLFSH
Sbjct: 81   DVSPLPPNPVVKARHRRGGVSAEVYTEEDAVSYVRKVIPKDYKTMTALAKAISKNVLFSH 140

Query: 563  LDDNERSDIFDAMFPVSFIAGETVIQQGDEGDNFYVIDQGEMDVYVNNEWATSVGEGGSF 742
            LDDNERSDIFDAMFPV+ IAGETVIQQGDEGDNFYVIDQGE+DVYVN EW TS+ EGGSF
Sbjct: 141  LDDNERSDIFDAMFPVTHIAGETVIQQGDEGDNFYVIDQGEVDVYVNGEWVTSISEGGSF 200

Query: 743  GELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSILESLD 922
            GELALIYGTPRAATVKAKT++KLWGIDRDSYRRILMGSTLRKR+MYEEFLSKVSIL SL+
Sbjct: 201  GELALIYGTPRAATVKAKTDLKLWGIDRDSYRRILMGSTLRKRRMYEEFLSKVSILASLE 260

Query: 923  KWERLTVADALEPVQFEDGQKIVVQGEQG 1009
            KWERLTVADALEPVQFEDG+KIVVQGE G
Sbjct: 261  KWERLTVADALEPVQFEDGEKIVVQGEPG 289



 Score = 70.1 bits (170), Expect = 3e-12
 Identities = 50/152 (32%), Positives = 78/152 (51%), Gaps = 9/152 (5%)
 Frame = +2

Query: 467 DAASYVRKVIPKDYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFPVSFIAGETVIQQG 646
           D  SY R ++    +      + + K  + + L+  ER  + DA+ PV F  GE ++ QG
Sbjct: 227 DRDSYRRILMGSTLRKRRMYEEFLSKVSILASLEKWERLTVADALEPVQFEDGEKIVVQG 286

Query: 647 DEGDNFYVIDQGEMDVYVN---NEWATSVGEGGS---FGELALIYGTPRAATVKAKTNVK 808
           + GD+F++I +G   V      +E    VG  G    FGE+AL+   PRAATV A+  +K
Sbjct: 287 EPGDDFFIITEGTASVLQRRSPSEEYVEVGRLGPSDYFGEIALLLNRPRAATVVARGPLK 346

Query: 809 LWGIDRDSYRRIL-MGSTLRKRKM--YEEFLS 895
              +DR  + R+L   S + KR +  Y  F+S
Sbjct: 347 CVKLDRPRFERVLGPCSEILKRNIQRYNSFIS 378


>ref|NP_001178296.1| cAMP-dependent protein kinase type II-alpha regulatory subunit [Bos
            taurus].
          Length = 401

 Score =  162 bits (409), Expect = 6e-40
 Identities = 108/285 (37%), Positives = 160/285 (56%), Gaps = 23/285 (8%)
 Frame = +2

Query: 230  LLKDSIVQLCTARPERPMAFLREYFERLEKEEAKQI----------QNLQK-----ASAR 364
            LL+   V++   RP   + F  +YF RL +  ++            Q+        A A 
Sbjct: 13   LLQGYTVEVLRQRPPDLVDFAVDYFTRLREARSRASTPPAAPPSGSQDFDPGAGLVADAV 72

Query: 365  ADSR-EDEISPPPPNPVVKGR-RRRGAISAEVYT--EEDAASYVRKVIPKDYKTMAALAK 532
            ADS  EDE     P P   GR  RR ++ AE Y   EE+  +  R + PK  +    L +
Sbjct: 73   ADSESEDEEDLDVPIP---GRFDRRVSVCAETYNPDEEEEDTDPRVIHPKTDQQRCRLQE 129

Query: 533  AIEKNVLFSHLDDNERSDIFDAMFPVSFIAGETVIQQGDEGDNFYVIDQGEMDVYVNNEW 712
            A +  +LF +LD  + S + DAMF  +    E VI QGD+GDNFYVI++G  D+ V  + 
Sbjct: 130  ACKDILLFKNLDPEQLSQVLDAMFERTVKVDEHVIDQGDDGDNFYVIERGTYDILVTKDN 189

Query: 713  AT-SVGE---GGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTLRKRKMY 880
             T SVG+    GSFGELAL+Y TPRAAT+ A +   LWG+DR ++RRI++ +  +KRKM+
Sbjct: 190  QTRSVGQYDNHGSFGELALMYNTPRAATIVATSEGSLWGLDRVTFRRIIVKNNAKKRKMF 249

Query: 881  EEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEQGTS 1015
            E F+  V +L+SL+  ER+ + D +    ++DG++I+ QGE+  S
Sbjct: 250  ESFIESVPLLKSLEVSERMKIVDVIGEKVYKDGERIITQGEKADS 294



 Score = 67.0 bits (162), Expect = 3e-11
 Identities = 48/162 (29%), Positives = 77/162 (47%), Gaps = 17/162 (10%)
 Frame = +2

Query: 467 DAASYVRKVIPKDYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFPVSFIAGETVIQQG 646
           D  ++ R ++  + K        IE   L   L+ +ER  I D +    +  GE +I QG
Sbjct: 230 DRVTFRRIIVKNNAKKRKMFESFIESVPLLKSLEVSERMKIVDVIGEKVYKDGERIITQG 289

Query: 647 DEGDNFYVIDQGEMDVYVNNEWATSVGEGGS--------------FGELALIYGTPRAAT 784
           ++ D+FY+I+ GE+ + + ++  T V + G               FGELAL+   PRAA+
Sbjct: 290 EKADSFYIIESGEVSILIKSK--TKVNKDGENQEVEIARCHKGQYFGELALVTNKPRAAS 347

Query: 785 VKAKTNVKLWGIDRDSYRRIL---MGSTLRKRKMYEEFLSKV 901
             A  +VK   +D  ++ R+L   M    R    YEE L K+
Sbjct: 348 AYAVGDVKCLVMDVQAFERLLGPCMDIMKRNISHYEEQLVKM 389


>ref|XP_002697092.1| PREDICTED: cAMP-dependent protein kinase, regulatory subunit alpha
            2-like [Bos taurus].
          Length = 401

 Score =  162 bits (409), Expect = 6e-40
 Identities = 108/285 (37%), Positives = 160/285 (56%), Gaps = 23/285 (8%)
 Frame = +2

Query: 230  LLKDSIVQLCTARPERPMAFLREYFERLEKEEAKQI----------QNLQK-----ASAR 364
            LL+   V++   RP   + F  +YF RL +  ++            Q+        A A 
Sbjct: 13   LLQGYTVEVLRQRPPDLVDFAVDYFTRLREARSRASTPPAAPPSGSQDFDPGAGLVADAV 72

Query: 365  ADSR-EDEISPPPPNPVVKGR-RRRGAISAEVYT--EEDAASYVRKVIPKDYKTMAALAK 532
            ADS  EDE     P P   GR  RR ++ AE Y   EE+  +  R + PK  +    L +
Sbjct: 73   ADSESEDEEDLDVPIP---GRFDRRVSVCAETYNPDEEEEDTDPRVIHPKTDQQRCRLQE 129

Query: 533  AIEKNVLFSHLDDNERSDIFDAMFPVSFIAGETVIQQGDEGDNFYVIDQGEMDVYVNNEW 712
            A +  +LF +LD  + S + DAMF  +    E VI QGD+GDNFYVI++G  D+ V  + 
Sbjct: 130  ACKDILLFKNLDPEQLSQVLDAMFERTVKVDEHVIDQGDDGDNFYVIERGTYDILVTKDN 189

Query: 713  AT-SVGE---GGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTLRKRKMY 880
             T SVG+    GSFGELAL+Y TPRAAT+ A +   LWG+DR ++RRI++ +  +KRKM+
Sbjct: 190  QTRSVGQYDNHGSFGELALMYNTPRAATIVATSEGSLWGLDRVTFRRIIVKNNAKKRKMF 249

Query: 881  EEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEQGTS 1015
            E F+  V +L+SL+  ER+ + D +    ++DG++I+ QGE+  S
Sbjct: 250  ESFIESVPLLKSLEVSERMKIVDVIGEKVYKDGERIITQGEKADS 294



 Score = 67.0 bits (162), Expect = 3e-11
 Identities = 48/162 (29%), Positives = 77/162 (47%), Gaps = 17/162 (10%)
 Frame = +2

Query: 467 DAASYVRKVIPKDYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFPVSFIAGETVIQQG 646
           D  ++ R ++  + K        IE   L   L+ +ER  I D +    +  GE +I QG
Sbjct: 230 DRVTFRRIIVKNNAKKRKMFESFIESVPLLKSLEVSERMKIVDVIGEKVYKDGERIITQG 289

Query: 647 DEGDNFYVIDQGEMDVYVNNEWATSVGEGGS--------------FGELALIYGTPRAAT 784
           ++ D+FY+I+ GE+ + + ++  T V + G               FGELAL+   PRAA+
Sbjct: 290 EKADSFYIIESGEVSILIKSK--TKVNKDGENQEVEIARCHKGQYFGELALVTNKPRAAS 347

Query: 785 VKAKTNVKLWGIDRDSYRRIL---MGSTLRKRKMYEEFLSKV 901
             A  +VK   +D  ++ R+L   M    R    YEE L K+
Sbjct: 348 AYAVGDVKCLVMDVQAFERLLGPCMDIMKRNISHYEEQLVKM 389


>ref|NP_777074.1| cAMP-dependent protein kinase type II-beta regulatory subunit [Bos
            taurus].
          Length = 418

 Score =  158 bits (400), Expect = 7e-39
 Identities = 89/211 (42%), Positives = 124/211 (58%), Gaps = 8/211 (3%)
 Frame = +2

Query: 407  PVVKGRRRRGAISAEVYT----EEDAASYVRKVIPKDYKTMAALAKAIEKNVLFSHLDDN 574
            PV+    RR ++ AE Y     E+DA S  R + PK       L +A +  +LF +LD  
Sbjct: 104  PVINRFTRRASVCAEAYNPDEEEDDAES--RIIHPKTDDQRNRLQEACKDILLFKNLDPE 161

Query: 575  ERSDIFDAMFPVSFIAGETVIQQGDEGDNFYVIDQGEMDVYVN----NEWATSVGEGGSF 742
            + S + DAMF      GE VI QGD+GDNFYVID+G  D+YV          +    GSF
Sbjct: 162  QMSQVLDAMFEKLVKEGEHVIDQGDDGDNFYVIDRGTFDIYVKCDGVGRCVGNYDNRGSF 221

Query: 743  GELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSILESLD 922
            GELAL+Y TPRAAT+ A +   LWG+DR ++RRI++ +  +KRKMYE F+  +  L+SL+
Sbjct: 222  GELALMYNTPRAATITATSPGALWGLDRVTFRRIIVKNNAKKRKMYESFIESLPFLKSLE 281

Query: 923  KWERLTVADALEPVQFEDGQKIVVQGEQGTS 1015
              ERL V D +    + DG++I+ QG+   S
Sbjct: 282  VSERLKVVDVIGTKVYNDGEQIIAQGDSADS 312



 Score = 65.5 bits (158), Expect = 8e-11
 Identities = 44/156 (28%), Positives = 72/156 (46%), Gaps = 14/156 (8%)
 Frame = +2

Query: 467 DAASYVRKVIPKDYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFPVSFIAGETVIQQG 646
           D  ++ R ++  + K        IE       L+ +ER  + D +    +  GE +I QG
Sbjct: 248 DRVTFRRIIVKNNAKKRKMYESFIESLPFLKSLEVSERLKVVDVIGTKVYNDGEQIIAQG 307

Query: 647 DEGDNFYVIDQGEMDVYVNNEWATSVGEGGS-----------FGELALIYGTPRAATVKA 793
           D  D+F++++ GE+ + +  +  + V E G+           FGELAL+   PRAA+  A
Sbjct: 308 DSADSFFIVESGEVKITMKRKGKSEVEENGAVEIARCSRGQYFGELALVTNKPRAASAHA 367

Query: 794 KTNVKLWGIDRDSYRRIL---MGSTLRKRKMYEEFL 892
              VK   +D  ++ R+L   M    R    YEE L
Sbjct: 368 IGTVKCLAMDVQAFERLLGPCMEIMKRNIATYEEQL 403


>ref|XP_596590.3| PREDICTED: cAMP-dependent protein kinase, regulatory subunit alpha 2
            [Bos taurus].
          Length = 329

 Score =  153 bits (387), Expect = 2e-37
 Identities = 83/199 (41%), Positives = 126/199 (63%), Gaps = 6/199 (3%)
 Frame = +2

Query: 437  AISAEVYT--EEDAASYVRKVIPKDYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFPV 610
            ++ AE Y   EE+  +  R + PK  +    L +A +  +LF +LD  + S + DAMF  
Sbjct: 24   SVCAETYNPDEEEEDTDPRVIHPKTDQQRCRLQEACKDILLFKNLDPEQLSQVLDAMFER 83

Query: 611  SFIAGETVIQQGDEGDNFYVIDQGEMDVYVNNEWAT-SVGE---GGSFGELALIYGTPRA 778
            +    E VI QGD+GDNFYVI++G  D+ V  +  T SVG+    GSFGELAL+Y TPRA
Sbjct: 84   TVKVDEHVIDQGDDGDNFYVIERGTYDILVTKDNQTRSVGQYDNHGSFGELALMYNTPRA 143

Query: 779  ATVKAKTNVKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSILESLDKWERLTVADALE 958
            AT+ A +   LWG+DR ++RRI++ +  +KRKM+E F+  V +L+SL+  ER+ + D + 
Sbjct: 144  ATIVATSEGSLWGLDRVTFRRIIVKNNAKKRKMFESFIESVPLLKSLEVSERMKIVDVIG 203

Query: 959  PVQFEDGQKIVVQGEQGTS 1015
               ++DG++I+ QGE+  S
Sbjct: 204  EKVYKDGERIITQGEKADS 222



 Score = 67.0 bits (162), Expect = 3e-11
 Identities = 48/162 (29%), Positives = 77/162 (47%), Gaps = 17/162 (10%)
 Frame = +2

Query: 467 DAASYVRKVIPKDYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFPVSFIAGETVIQQG 646
           D  ++ R ++  + K        IE   L   L+ +ER  I D +    +  GE +I QG
Sbjct: 158 DRVTFRRIIVKNNAKKRKMFESFIESVPLLKSLEVSERMKIVDVIGEKVYKDGERIITQG 217

Query: 647 DEGDNFYVIDQGEMDVYVNNEWATSVGEGGS--------------FGELALIYGTPRAAT 784
           ++ D+FY+I+ GE+ + + ++  T V + G               FGELAL+   PRAA+
Sbjct: 218 EKADSFYIIESGEVSILIKSK--TKVNKDGENQEVEIARCHKGQYFGELALVTNKPRAAS 275

Query: 785 VKAKTNVKLWGIDRDSYRRIL---MGSTLRKRKMYEEFLSKV 901
             A  +VK   +D  ++ R+L   M    R    YEE L K+
Sbjct: 276 AYAVGDVKCLVMDVQAFERLLGPCMDIMKRNISHYEEQLVKM 317


>ref|NP_776861.1| cGMP-dependent protein kinase 1 [Bos taurus].
          Length = 671

 Score =  121 bits (303), Expect = 1e-27
 Identities = 82/262 (31%), Positives = 134/262 (51%), Gaps = 3/262 (1%)
 Frame = +2

Query: 233  LKDSIVQLCTARPERPMAFLREYFERLEKEEAKQIQNLQKASARADSREDEISPPPPNPV 412
            L++   ++   + ER    ++E  +RL ++E ++IQ L++   +  S    + P P   +
Sbjct: 4    LEEDFAKILMLKEER----IKELEKRLSEKE-EEIQELKRKLHKCQS----VLPVPSTHI 54

Query: 413  VKGRRRRGAISAEVYTEE---DAASYVRKVIPKDYKTMAALAKAIEKNVLFSHLDDNERS 583
                 R   ISAE  T     D     RK   K  ++   + +AI  N    +L+ ++  
Sbjct: 55   GPRTTRAQGISAEPQTYRSFHDLRQAFRK-FTKSERSKDLIKEAILDNDFMKNLELSQIQ 113

Query: 584  DIFDAMFPVSFIAGETVIQQGDEGDNFYVIDQGEMDVYVNNEWATSVGEGGSFGELALIY 763
            +I D M+PV +     +I++GD G   YV++ G+++V        ++G G  FGELA++Y
Sbjct: 114  EIVDCMYPVEYGKDSCIIKEGDVGSLVYVMEDGKVEVTKEGVKLCTMGPGKVFGELAILY 173

Query: 764  GTPRAATVKAKTNVKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSILESLDKWERLTV 943
               R ATVK   NVKLW IDR  ++ I+M + L K   Y EFL  V   +SL +     +
Sbjct: 174  NCTRTATVKTLVNVKLWAIDRQCFQTIMMRTGLIKHTEYMEFLKSVPTFQSLPEEILSKL 233

Query: 944  ADALEPVQFEDGQKIVVQGEQG 1009
            AD LE   +E+G+ I+ QG +G
Sbjct: 234  ADVLEETHYENGEYIIRQGARG 255



 Score = 55.1 bits (131), Expect = 1e-07
 Identities = 37/121 (30%), Positives = 60/121 (49%), Gaps = 6/121 (4%)
 Frame = +2

Query: 554 FSHLDDNERSDIFDAMFPVSFIAGETVIQQGDEGDNFYVIDQGEMDVYVNNE------WA 715
           F  L +   S + D +    +  GE +I+QG  GD F++I +G+++V   +       + 
Sbjct: 222 FQSLPEEILSKLADVLEETHYENGEYIIRQGARGDTFFIISKGKVNVTREDSPNEDPVFL 281

Query: 716 TSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTLRKRKMYEEFLS 895
            ++G+G  FGE AL     R A V A   V    IDRDS++ ++ G      K YE+  +
Sbjct: 282 RTLGKGDWFGEKALQGEDVRTANVIAAEAVTCLVIDRDSFKHLIGGLDDVSNKAYEDAEA 341

Query: 896 K 898
           K
Sbjct: 342 K 342


>ref|NP_001137571.1| cGMP-dependent protein kinase 2 [Bos taurus].
          Length = 762

 Score =  110 bits (275), Expect = 2e-24
 Identities = 61/205 (29%), Positives = 112/205 (54%), Gaps = 9/205 (4%)
 Frame = +2

Query: 428  RRGA---ISAEVYT------EEDAASYVRKVIPKDYKTMAALAKAIEKNVLFSHLDDNER 580
            RRGA   +SAE  T      +    S+ +  + KD      +  A+ KN     LD  + 
Sbjct: 118  RRGAKAGVSAEPTTRTYDLNKPPEFSFEKARVRKDSSEKKLITDALNKNQFLKRLDPQQI 177

Query: 581  SDIFDAMFPVSFIAGETVIQQGDEGDNFYVIDQGEMDVYVNNEWATSVGEGGSFGELALI 760
             D+ + M+  ++  G  +I+QG+ G++ +V+ +G ++V    +  +S+    +FGELA++
Sbjct: 178  KDMVECMYGRNYQQGSYIIKQGEPGNHIFVLAEGRLEVSQGEKLLSSIPMWTTFGELAIL 237

Query: 761  YGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSILESLDKWERLT 940
            Y   R A+VKA TNVK W +DR+ ++ I+  +   + + Y  FL  VS+L++L + +   
Sbjct: 238  YNCTRTASVKAITNVKTWALDREVFQNIMRRTAQARDEQYRNFLRSVSLLKNLPEDKLTK 297

Query: 941  VADALEPVQFEDGQKIVVQGEQGTS 1015
            + D LE   ++ G  I+ +GE+G++
Sbjct: 298  IIDCLEVEYYDKGDYIIREGEEGST 322


>ref|XP_002698219.1| PREDICTED: protein kinase, cAMP-dependent, regulatory, type I,
           beta-like [Bos taurus].
          Length = 201

 Score = 63.2 bits (152), Expect = 4e-10
 Identities = 29/39 (74%), Positives = 33/39 (84%)
 Frame = +2

Query: 203 YVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEK 319
           YVQ+  IQ +LKD IVQLC A+PERPM FLRE+FERLEK
Sbjct: 21  YVQRRGIQQVLKDCIVQLCLAKPERPMRFLREHFERLEK 59


>ref|NP_001073771.1| rap guanine nucleotide exchange factor 3 [Bos taurus].
          Length = 923

 Score = 54.3 bits (129), Expect = 2e-07
 Identities = 35/122 (28%), Positives = 66/122 (54%), Gaps = 3/122 (2%)
 Frame = +2

Query: 557 SHLDDNERSDIFDAM-FPVSFIAGETVIQQGDEGDNFYVIDQGEMDVYVNNEW-ATSVGE 730
           +HL ++ + ++   + F     AG  +  QGD+G ++Y+I +G ++V  + +   T++ E
Sbjct: 247 AHLSNSVKRELAAVLLFEPHSKAGTVLFSQGDKGTSWYIIWKGSVNVVTHGKGLVTTLHE 306

Query: 731 GGSFGELALIYGTPRAAT-VKAKTNVKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSI 907
           G  FG+LAL+   PRAAT +  + N     +D+  + RI+     +  ++ EE    V +
Sbjct: 307 GDDFGQLALVNDAPRAATIILGEDNCHFLRVDKQDFNRIIKDVEAKTMRL-EEHGKVVLV 365

Query: 908 LE 913
           LE
Sbjct: 366 LE 367


  Database: RefSeq49_BP.fasta
    Posted date:  Oct 17, 2011  1:42 PM
  Number of letters in database: 17,681,374
  Number of sequences in database:  33,088
  
Lambda     K      H
   0.318    0.134    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 33088
Number of Hits to DB: 40,127,096
Number of extensions: 1085164
Number of successful extensions: 4379
Number of sequences better than 1.0e-05: 12
Number of HSP's gapped: 4332
Number of HSP's successfully gapped: 19
Length of query: 351
Length of database: 17,681,374
Length adjustment: 103
Effective length of query: 248
Effective length of database: 14,273,310
Effective search space: 3539780880
Effective search space used: 3539780880
Neighboring words threshold: 12
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 34 (17.7 bits)

BLASTX 2.2.24 [Aug-08-2010]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= 20110601C-007684
         (1055 letters)

Database: RefSeq49_CP.fasta 
           33,336 sequences; 18,874,504 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

Alignment   gi|XP_862649.1| PREDICTED: similar to cAMP-dependent protein ki...   532   e-151
Alignment   gi|XP_537577.2| PREDICTED: similar to cAMP-dependent protein ki...   532   e-151
Alignment   gi|XP_862625.1| PREDICTED: similar to cAMP-dependent protein ki...   505   e-143
Alignment   gi|XP_862606.1| PREDICTED: similar to protein kinase, cAMP depe...   503   e-142
Alignment   gi|XP_537920.2| PREDICTED: similar to protein kinase, cAMP-depe...   453   e-127
Alignment   gi|XP_856004.1| PREDICTED: similar to protein kinase, cAMP-depe...   441   e-124
Alignment   gi|XP_857982.1| PREDICTED: similar to cAMP-dependent protein ki...   166   3e-41
Alignment   gi|XP_541890.2| PREDICTED: similar to cAMP-dependent protein ki...   162   6e-40
Alignment   gi|XP_858066.1| PREDICTED: similar to cAMP-dependent protein ki...   161   8e-40
Alignment   gi|XP_857939.1| PREDICTED: similar to cAMP-dependent protein ki...   161   1e-39

>ref|XP_862649.1| PREDICTED: similar to cAMP-dependent protein kinase type I-alpha
            regulatory subunit (Tissue-specific extinguisher-1)
            (TSE1) isoform 4 [Canis familiaris].
          Length = 381

 Score =  532 bits (1371), Expect = e-151
 Identities = 274/289 (94%), Positives = 275/289 (95%), Gaps = 1/289 (0%)
 Frame = +2

Query: 146  MASGSTAXXXXXXXXXXXX-YVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKE 322
            MASGSTA             YVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKE
Sbjct: 1    MASGSTATSEEERSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKE 60

Query: 323  EAKQIQNLQKASARADSREDEISPPPPNPVVKGRRRRGAISAEVYTEEDAASYVRKVIPK 502
            EAKQIQNLQKAS+RADSREDEISPPPPNPVVKGRRRRGAISAEVYTEEDAASYVRKVIPK
Sbjct: 61   EAKQIQNLQKASSRADSREDEISPPPPNPVVKGRRRRGAISAEVYTEEDAASYVRKVIPK 120

Query: 503  DYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFPVSFIAGETVIQQGDEGDNFYVIDQG 682
            DYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFPVSFIAGETVIQQGDEGDNFYVIDQG
Sbjct: 121  DYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFPVSFIAGETVIQQGDEGDNFYVIDQG 180

Query: 683  EMDVYVNNEWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTL 862
            EMDVYVNNEWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTL
Sbjct: 181  EMDVYVNNEWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTL 240

Query: 863  RKRKMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEQG 1009
            RKRKMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGE G
Sbjct: 241  RKRKMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEPG 289



 Score = 69.7 bits (169), Expect = 4e-12
 Identities = 51/152 (33%), Positives = 76/152 (50%), Gaps = 9/152 (5%)
 Frame = +2

Query: 467 DAASYVRKVIPKDYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFPVSFIAGETVIQQG 646
           D  SY R ++    +      + + K  +   LD  ER  + DA+ PV F  G+ ++ QG
Sbjct: 227 DRDSYRRILMGSTLRKRKMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQG 286

Query: 647 DEGDNFYVIDQGEMDVY---VNNEWATSVGEGGS---FGELALIYGTPRAATVKAKTNVK 808
           + GD F++I +G   V      NE    VG  G    FGE+AL+   PRAATV A+  +K
Sbjct: 287 EPGDEFFIILEGSAAVLQRRSENEEFVEVGRLGPSDYFGEIALLMNRPRAATVVARGPLK 346

Query: 809 LWGIDRDSYRRIL-MGSTLRKR--KMYEEFLS 895
              +DR  + R+L   S + KR  + Y  F+S
Sbjct: 347 CVKLDRPRFERVLGPCSDILKRNIQQYNSFVS 378


>ref|XP_537577.2| PREDICTED: similar to cAMP-dependent protein kinase type I-alpha
            regulatory subunit (Tissue-specific extinguisher-1)
            (TSE1) isoform 1 [Canis familiaris].
          Length = 381

 Score =  532 bits (1371), Expect = e-151
 Identities = 274/289 (94%), Positives = 275/289 (95%), Gaps = 1/289 (0%)
 Frame = +2

Query: 146  MASGSTAXXXXXXXXXXXX-YVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKE 322
            MASGSTA             YVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKE
Sbjct: 1    MASGSTATSEEERSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKE 60

Query: 323  EAKQIQNLQKASARADSREDEISPPPPNPVVKGRRRRGAISAEVYTEEDAASYVRKVIPK 502
            EAKQIQNLQKAS+RADSREDEISPPPPNPVVKGRRRRGAISAEVYTEEDAASYVRKVIPK
Sbjct: 61   EAKQIQNLQKASSRADSREDEISPPPPNPVVKGRRRRGAISAEVYTEEDAASYVRKVIPK 120

Query: 503  DYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFPVSFIAGETVIQQGDEGDNFYVIDQG 682
            DYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFPVSFIAGETVIQQGDEGDNFYVIDQG
Sbjct: 121  DYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFPVSFIAGETVIQQGDEGDNFYVIDQG 180

Query: 683  EMDVYVNNEWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTL 862
            EMDVYVNNEWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTL
Sbjct: 181  EMDVYVNNEWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTL 240

Query: 863  RKRKMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEQG 1009
            RKRKMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGE G
Sbjct: 241  RKRKMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEPG 289



 Score = 69.7 bits (169), Expect = 4e-12
 Identities = 51/152 (33%), Positives = 76/152 (50%), Gaps = 9/152 (5%)
 Frame = +2

Query: 467 DAASYVRKVIPKDYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFPVSFIAGETVIQQG 646
           D  SY R ++    +      + + K  +   LD  ER  + DA+ PV F  G+ ++ QG
Sbjct: 227 DRDSYRRILMGSTLRKRKMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQG 286

Query: 647 DEGDNFYVIDQGEMDVY---VNNEWATSVGEGGS---FGELALIYGTPRAATVKAKTNVK 808
           + GD F++I +G   V      NE    VG  G    FGE+AL+   PRAATV A+  +K
Sbjct: 287 EPGDEFFIILEGSAAVLQRRSENEEFVEVGRLGPSDYFGEIALLMNRPRAATVVARGPLK 346

Query: 809 LWGIDRDSYRRIL-MGSTLRKR--KMYEEFLS 895
              +DR  + R+L   S + KR  + Y  F+S
Sbjct: 347 CVKLDRPRFERVLGPCSDILKRNIQQYNSFVS 378


>ref|XP_862625.1| PREDICTED: similar to cAMP-dependent protein kinase type I-alpha
            regulatory subunit isoform 3 [Canis familiaris].
          Length = 377

 Score =  505 bits (1301), Expect = e-143
 Identities = 263/289 (91%), Positives = 267/289 (92%), Gaps = 1/289 (0%)
 Frame = +2

Query: 146  MASGSTAXXXXXXXXXXXX-YVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKE 322
            MASGSTA             YVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEK 
Sbjct: 1    MASGSTATSEEERSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKV 60

Query: 323  EAKQIQNLQKASARADSREDEISPPPPNPVVKGRRRRGAISAEVYTEEDAASYVRKVIPK 502
            + +Q  N    ++RADSREDEISPPPPNPVVKGRRRRGAISAEVYTEEDAASYVRKVIPK
Sbjct: 61   KIRQGGN----NSRADSREDEISPPPPNPVVKGRRRRGAISAEVYTEEDAASYVRKVIPK 116

Query: 503  DYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFPVSFIAGETVIQQGDEGDNFYVIDQG 682
            DYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFPVSFIAGETVIQQGDEGDNFYVIDQG
Sbjct: 117  DYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFPVSFIAGETVIQQGDEGDNFYVIDQG 176

Query: 683  EMDVYVNNEWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTL 862
            EMDVYVNNEWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTL
Sbjct: 177  EMDVYVNNEWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTL 236

Query: 863  RKRKMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEQG 1009
            RKRKMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGE G
Sbjct: 237  RKRKMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEPG 285



 Score = 69.7 bits (169), Expect = 4e-12
 Identities = 51/152 (33%), Positives = 76/152 (50%), Gaps = 9/152 (5%)
 Frame = +2

Query: 467 DAASYVRKVIPKDYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFPVSFIAGETVIQQG 646
           D  SY R ++    +      + + K  +   LD  ER  + DA+ PV F  G+ ++ QG
Sbjct: 223 DRDSYRRILMGSTLRKRKMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQG 282

Query: 647 DEGDNFYVIDQGEMDVY---VNNEWATSVGEGGS---FGELALIYGTPRAATVKAKTNVK 808
           + GD F++I +G   V      NE    VG  G    FGE+AL+   PRAATV A+  +K
Sbjct: 283 EPGDEFFIILEGSAAVLQRRSENEEFVEVGRLGPSDYFGEIALLMNRPRAATVVARGPLK 342

Query: 809 LWGIDRDSYRRIL-MGSTLRKR--KMYEEFLS 895
              +DR  + R+L   S + KR  + Y  F+S
Sbjct: 343 CVKLDRPRFERVLGPCSDILKRNIQQYNSFVS 374


>ref|XP_862606.1| PREDICTED: similar to protein kinase, cAMP dependent regulatory, type
            I, alpha isoform 2 [Canis familiaris].
          Length = 373

 Score =  503 bits (1294), Expect = e-142
 Identities = 262/289 (90%), Positives = 265/289 (91%), Gaps = 1/289 (0%)
 Frame = +2

Query: 146  MASGSTAXXXXXXXXXXXX-YVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKE 322
            MASGSTA             YVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEK 
Sbjct: 1    MASGSTATSEEERSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEK- 59

Query: 323  EAKQIQNLQKASARADSREDEISPPPPNPVVKGRRRRGAISAEVYTEEDAASYVRKVIPK 502
                   ++  S+RADSREDEISPPPPNPVVKGRRRRGAISAEVYTEEDAASYVRKVIPK
Sbjct: 60   -------VKITSSRADSREDEISPPPPNPVVKGRRRRGAISAEVYTEEDAASYVRKVIPK 112

Query: 503  DYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFPVSFIAGETVIQQGDEGDNFYVIDQG 682
            DYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFPVSFIAGETVIQQGDEGDNFYVIDQG
Sbjct: 113  DYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFPVSFIAGETVIQQGDEGDNFYVIDQG 172

Query: 683  EMDVYVNNEWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTL 862
            EMDVYVNNEWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTL
Sbjct: 173  EMDVYVNNEWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTL 232

Query: 863  RKRKMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEQG 1009
            RKRKMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGE G
Sbjct: 233  RKRKMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEPG 281



 Score = 69.7 bits (169), Expect = 4e-12
 Identities = 51/152 (33%), Positives = 76/152 (50%), Gaps = 9/152 (5%)
 Frame = +2

Query: 467 DAASYVRKVIPKDYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFPVSFIAGETVIQQG 646
           D  SY R ++    +      + + K  +   LD  ER  + DA+ PV F  G+ ++ QG
Sbjct: 219 DRDSYRRILMGSTLRKRKMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQG 278

Query: 647 DEGDNFYVIDQGEMDVY---VNNEWATSVGEGGS---FGELALIYGTPRAATVKAKTNVK 808
           + GD F++I +G   V      NE    VG  G    FGE+AL+   PRAATV A+  +K
Sbjct: 279 EPGDEFFIILEGSAAVLQRRSENEEFVEVGRLGPSDYFGEIALLMNRPRAATVVARGPLK 338

Query: 809 LWGIDRDSYRRIL-MGSTLRKR--KMYEEFLS 895
              +DR  + R+L   S + KR  + Y  F+S
Sbjct: 339 CVKLDRPRFERVLGPCSDILKRNIQQYNSFVS 370


>ref|XP_537920.2| PREDICTED: similar to protein kinase, cAMP-dependent, regulatory,
            type I, beta isoform 1 [Canis familiaris].
          Length = 377

 Score =  453 bits (1165), Expect = e-127
 Identities = 223/269 (82%), Positives = 245/269 (91%)
 Frame = +2

Query: 203  YVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKEEAKQIQNLQKASARADSRED 382
            YVQKH +Q +LKD IV LC ++P+RPM FLRE+FE+LEKEE +QIQ+ QK+    DS ++
Sbjct: 21   YVQKHGVQQVLKDCIVHLCISKPDRPMTFLREHFEKLEKEENRQIQSQQKS----DSHDE 76

Query: 383  EISPPPPNPVVKGRRRRGAISAEVYTEEDAASYVRKVIPKDYKTMAALAKAIEKNVLFSH 562
            E+SP PPNPVVK RRRRG +SAEVYTEEDA SYVRKVIPKDYKTM ALAKAI KNVLF+H
Sbjct: 77   EVSPTPPNPVVKARRRRGGVSAEVYTEEDAVSYVRKVIPKDYKTMTALAKAISKNVLFAH 136

Query: 563  LDDNERSDIFDAMFPVSFIAGETVIQQGDEGDNFYVIDQGEMDVYVNNEWATSVGEGGSF 742
            LDDNERSDIFDAMFPV+ IAGETVIQQGDEGDNFYVIDQGE+DVYVN EW TS+ EGGSF
Sbjct: 137  LDDNERSDIFDAMFPVTHIAGETVIQQGDEGDNFYVIDQGEVDVYVNGEWVTSISEGGSF 196

Query: 743  GELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSILESLD 922
            GELALIYGTPRAATVKAKT++KLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSILESL+
Sbjct: 197  GELALIYGTPRAATVKAKTDLKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSILESLE 256

Query: 923  KWERLTVADALEPVQFEDGQKIVVQGEQG 1009
            KWERLTVADALEPVQFEDG+KIVVQGE G
Sbjct: 257  KWERLTVADALEPVQFEDGEKIVVQGEPG 285



 Score = 71.2 bits (173), Expect = 2e-12
 Identities = 51/152 (33%), Positives = 77/152 (50%), Gaps = 9/152 (5%)
 Frame = +2

Query: 467 DAASYVRKVIPKDYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFPVSFIAGETVIQQG 646
           D  SY R ++    +      + + K  +   L+  ER  + DA+ PV F  GE ++ QG
Sbjct: 223 DRDSYRRILMGSTLRKRKMYEEFLSKVSILESLEKWERLTVADALEPVQFEDGEKIVVQG 282

Query: 647 DEGDNFYVIDQGEMDVYVN---NEWATSVGEGGS---FGELALIYGTPRAATVKAKTNVK 808
           + GD+F++I +G   V      NE    VG  G    FGE+AL+   PRAATV A+  +K
Sbjct: 283 EPGDDFFIITEGTASVLQRRSPNEEYMEVGRLGPSDYFGEIALLLNRPRAATVVARGPLK 342

Query: 809 LWGIDRDSYRRIL-MGSTLRKRKM--YEEFLS 895
              +DR  + R+L   S + KR +  Y  F+S
Sbjct: 343 CVKLDRPRFERVLGPCSEILKRNIQRYNSFIS 374


>ref|XP_856004.1| PREDICTED: similar to protein kinase, cAMP-dependent, regulatory,
            type I, beta isoform 3 [Canis familiaris].
          Length = 380

 Score =  441 bits (1133), Expect = e-124
 Identities = 220/274 (80%), Positives = 240/274 (87%), Gaps = 5/274 (1%)
 Frame = +2

Query: 203  YVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKEEAKQIQNLQKASARA----- 367
            YVQKH +Q +LKD IV LC ++P+RPM FLRE+FE+LEK       NLQ    R+     
Sbjct: 21   YVQKHGVQQVLKDCIVHLCISKPDRPMTFLREHFEKLEK------MNLQTGDGRSAVPPS 74

Query: 368  DSREDEISPPPPNPVVKGRRRRGAISAEVYTEEDAASYVRKVIPKDYKTMAALAKAIEKN 547
            DS ++E+SP PPNPVVK RRRRG +SAEVYTEEDA SYVRKVIPKDYKTM ALAKAI KN
Sbjct: 75   DSHDEEVSPTPPNPVVKARRRRGGVSAEVYTEEDAVSYVRKVIPKDYKTMTALAKAISKN 134

Query: 548  VLFSHLDDNERSDIFDAMFPVSFIAGETVIQQGDEGDNFYVIDQGEMDVYVNNEWATSVG 727
            VLF+HLDDNERSDIFDAMFPV+ IAGETVIQQGDEGDNFYVIDQGE+DVYVN EW TS+ 
Sbjct: 135  VLFAHLDDNERSDIFDAMFPVTHIAGETVIQQGDEGDNFYVIDQGEVDVYVNGEWVTSIS 194

Query: 728  EGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSI 907
            EGGSFGELALIYGTPRAATVKAKT++KLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSI
Sbjct: 195  EGGSFGELALIYGTPRAATVKAKTDLKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSI 254

Query: 908  LESLDKWERLTVADALEPVQFEDGQKIVVQGEQG 1009
            LESL+KWERLTVADALEPVQFEDG+KIVVQGE G
Sbjct: 255  LESLEKWERLTVADALEPVQFEDGEKIVVQGEPG 288



 Score = 71.2 bits (173), Expect = 2e-12
 Identities = 51/152 (33%), Positives = 77/152 (50%), Gaps = 9/152 (5%)
 Frame = +2

Query: 467 DAASYVRKVIPKDYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFPVSFIAGETVIQQG 646
           D  SY R ++    +      + + K  +   L+  ER  + DA+ PV F  GE ++ QG
Sbjct: 226 DRDSYRRILMGSTLRKRKMYEEFLSKVSILESLEKWERLTVADALEPVQFEDGEKIVVQG 285

Query: 647 DEGDNFYVIDQGEMDVYVN---NEWATSVGEGGS---FGELALIYGTPRAATVKAKTNVK 808
           + GD+F++I +G   V      NE    VG  G    FGE+AL+   PRAATV A+  +K
Sbjct: 286 EPGDDFFIITEGTASVLQRRSPNEEYMEVGRLGPSDYFGEIALLLNRPRAATVVARGPLK 345

Query: 809 LWGIDRDSYRRIL-MGSTLRKRKM--YEEFLS 895
              +DR  + R+L   S + KR +  Y  F+S
Sbjct: 346 CVKLDRPRFERVLGPCSEILKRNIQRYNSFIS 377


>ref|XP_857982.1| PREDICTED: similar to cAMP-dependent protein kinase type II-beta
            regulatory subunit isoform 9 [Canis familiaris].
          Length = 398

 Score =  166 bits (420), Expect = 3e-41
 Identities = 100/285 (35%), Positives = 153/285 (53%), Gaps = 23/285 (8%)
 Frame = +2

Query: 230  LLKDSIVQLCTARPERPMAFLREYFERLEKEEAK---------------QIQNLQKASAR 364
            LL+   V++   +P   + F  ++F RL++E  +               ++  ++ A   
Sbjct: 12   LLQGFTVEVLRHQPADLLDFALQHFTRLQQENERRGAAIISPPNRRPFQEVFGVKTAQEE 71

Query: 365  ADSREDEISPPPPNPVVKGRRRRGAISAEVYT----EEDAASYVRKVIPKDYKTMAALAK 532
             +++ +     P  PV+    RR ++ AE Y     E+DA S  R + PK       L +
Sbjct: 72   GEAKLNCSDRDPKTPVINRFTRRASVCAEAYNPDEEEDDAES--RIIHPKTDDQRNRLQE 129

Query: 533  AIEKNVLFSHLDDNERSDIFDAMFPVSFIAGETVIQQGDEGDNFYVIDQGEMDVYVN--- 703
            A +  +LF +LD  + S + DAMF      GE VI QGD+GDNFYVID+G  D+YV    
Sbjct: 130  ACKDILLFKNLDPEQMSQVLDAMFEKLVKEGEHVIDQGDDGDNFYVIDRGTFDIYVKCDG 189

Query: 704  -NEWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTLRKRKMY 880
                  +    GSFGELAL+Y TPRAAT+ A +   LWG+DR ++RRI++ +  +KRKMY
Sbjct: 190  VGRCVGNYDNRGSFGELALMYNTPRAATITATSPGALWGLDRVTFRRIIVKNNAKKRKMY 249

Query: 881  EEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEQGTS 1015
            E F+  +  L+SL+  ERL V D +    + DG++I+ QG+   S
Sbjct: 250  ESFIESLPFLKSLEVSERLKVVDVIGTKVYNDGEQIIAQGDSADS 294



 Score = 62.0 bits (149), Expect = 9e-10
 Identities = 45/154 (29%), Positives = 70/154 (45%), Gaps = 12/154 (7%)
 Frame = +2

Query: 467 DAASYVRKVIPKDYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFPVSFIAGETVIQQG 646
           D  ++ R ++  + K        IE       L+ +ER  + D +    +  GE +I QG
Sbjct: 230 DRVTFRRIIVKNNAKKRKMYESFIESLPFLKSLEVSERLKVVDVIGTKVYNDGEQIIAQG 289

Query: 647 DEGDNFYVIDQGEM------DVYVNNEWATSV---GEGGSFGELALIYGTPRAATVKAKT 799
           D  D+F++++ GE+       V V  + A  +     G  FGELAL+   PRAA+  A  
Sbjct: 290 DSADSFFIVESGEVKITMKRKVKVEEDGAVEIARCSRGQYFGELALVTNKPRAASAHAIG 349

Query: 800 NVKLWGIDRDSYRRIL---MGSTLRKRKMYEEFL 892
            VK   +D  ++ R+L   M    R    YEE L
Sbjct: 350 TVKCLAMDVQAFERLLGPCMEIMKRNIATYEEQL 383


>ref|XP_541890.2| PREDICTED: similar to cAMP-dependent protein kinase type II-alpha
            regulatory subunit isoform 1 [Canis familiaris].
          Length = 401

 Score =  162 bits (409), Expect = 6e-40
 Identities = 103/283 (36%), Positives = 158/283 (55%), Gaps = 21/283 (7%)
 Frame = +2

Query: 230  LLKDSIVQLCTARPERPMAFLREYFERLEKEEAKQI----------QNLQK-----ASAR 364
            LL+   V++   +P   + F  +YF RL +   +            Q L+      A A+
Sbjct: 13   LLQGYTVEVLRQQPPDLVDFAVDYFTRLREARLQASSPPAAPPSGSQGLEPSPGLVADAK 72

Query: 365  ADSREDEISPPPPNPVVKGRRRRGAISAEVYT--EEDAASYVRKVIPKDYKTMAALAKAI 538
            ADS E E       P+     RR ++ AE Y   EE+  +  R + PK  +    L +A 
Sbjct: 73   ADS-ESEDDEDLDVPIPSRFDRRVSVCAETYNPDEEEEDTDPRVIHPKTDQQRCRLQEAC 131

Query: 539  EKNVLFSHLDDNERSDIFDAMFPVSFIAGETVIQQGDEGDNFYVIDQGEMDVYVNNEWAT 718
            +  +LF +LD  + S + DAMF  +    E VI QGD+GDNFYVI++G  D+ V  +  T
Sbjct: 132  KDILLFKNLDQEQLSQVLDAMFERTVKVDEHVIDQGDDGDNFYVIERGTYDILVTKDNQT 191

Query: 719  -SVGE---GGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTLRKRKMYEE 886
             SVG+    GSFGELAL+Y TPRAAT+ A +   LWG+DR ++RRI++ +  +KR+M+E 
Sbjct: 192  RSVGQYDNRGSFGELALMYNTPRAATIIATSEGSLWGLDRVTFRRIIVKNNAKKRRMFES 251

Query: 887  FLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEQGTS 1015
            F+  V +L+SL+  ER+ + D +    ++DG++I+ QGE+  S
Sbjct: 252  FIESVPLLKSLEMSERMKIVDVIGEKAYKDGERIITQGEKADS 294



 Score = 67.8 bits (164), Expect = 2e-11
 Identities = 46/160 (28%), Positives = 76/160 (47%), Gaps = 15/160 (9%)
 Frame = +2

Query: 467 DAASYVRKVIPKDYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFPVSFIAGETVIQQG 646
           D  ++ R ++  + K        IE   L   L+ +ER  I D +   ++  GE +I QG
Sbjct: 230 DRVTFRRIIVKNNAKKRRMFESFIESVPLLKSLEMSERMKIVDVIGEKAYKDGERIITQG 289

Query: 647 DEGDNFYVIDQGEMDVYVNNEWATSVGEGGS------------FGELALIYGTPRAATVK 790
           ++ D+FY+I+ GE+ + + ++   +   G              FGELAL+   PRAA+  
Sbjct: 290 EKADSFYIIESGEVSILIRSKTKANKDGGNQEVEIARCHKGQYFGELALVTNKPRAASAY 349

Query: 791 AKTNVKLWGIDRDSYRRIL---MGSTLRKRKMYEEFLSKV 901
           A  +VK   +D  ++ R+L   M    R    YEE L K+
Sbjct: 350 AVGDVKCLVMDVQAFERLLGPCMDIMKRNISHYEEQLVKM 389


>ref|XP_858066.1| PREDICTED: similar to cAMP-dependent protein kinase, regulatory
            subunit beta 2 isoform 10 [Canis familiaris].
          Length = 412

 Score =  161 bits (408), Expect = 8e-40
 Identities = 95/234 (40%), Positives = 133/234 (56%), Gaps = 9/234 (3%)
 Frame = +2

Query: 341  NLQKASARADSRE-DEISPPPPNPVVKGRRRRGAISAEVYT----EEDAASYVRKVIPKD 505
            N  +  AR DS + +E       PV+    RR ++ AE Y     E+DA S  R + PK 
Sbjct: 75   NFAEEPARTDSEDAEEEEEEYVAPVINRFTRRASVCAEAYNPDEEEDDAES--RIIHPKT 132

Query: 506  YKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFPVSFIAGETVIQQGDEGDNFYVIDQGE 685
                  L +A +  +LF +LD  + S + DAMF      GE VI QGD+GDNFYVID+G 
Sbjct: 133  DDQRNRLQEACKDILLFKNLDPEQMSQVLDAMFEKLVKEGEHVIDQGDDGDNFYVIDRGT 192

Query: 686  MDVYVN----NEWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMG 853
             D+YV          +    GSFGELAL+Y TPRAAT+ A +   LWG+DR ++RRI++ 
Sbjct: 193  FDIYVKCDGVGRCVGNYDNRGSFGELALMYNTPRAATITATSPGALWGLDRVTFRRIIVK 252

Query: 854  STLRKRKMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEQGTS 1015
            +  +KRKMYE F+  +  L+SL+  ERL V D +    + DG++I+ QG+   S
Sbjct: 253  NNAKKRKMYESFIESLPFLKSLEVSERLKVVDVIGTKVYNDGEQIIAQGDSADS 306



 Score = 65.1 bits (157), Expect = 1e-10
 Identities = 44/156 (28%), Positives = 72/156 (46%), Gaps = 14/156 (8%)
 Frame = +2

Query: 467 DAASYVRKVIPKDYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFPVSFIAGETVIQQG 646
           D  ++ R ++  + K        IE       L+ +ER  + D +    +  GE +I QG
Sbjct: 242 DRVTFRRIIVKNNAKKRKMYESFIESLPFLKSLEVSERLKVVDVIGTKVYNDGEQIIAQG 301

Query: 647 DEGDNFYVIDQGEMDVYVNNEWATSVGEGGS-----------FGELALIYGTPRAATVKA 793
           D  D+F++++ GE+ + +  +  + V E G+           FGELAL+   PRAA+  A
Sbjct: 302 DSADSFFIVESGEVKITMKRKGKSEVEEDGAVEIARCSRGQYFGELALVTNKPRAASAHA 361

Query: 794 KTNVKLWGIDRDSYRRIL---MGSTLRKRKMYEEFL 892
              VK   +D  ++ R+L   M    R    YEE L
Sbjct: 362 IGTVKCLAMDVQAFERLLGPCMEIMKRNIATYEEQL 397


>ref|XP_857939.1| PREDICTED: similar to cAMP-dependent protein kinase type II-beta
            regulatory subunit isoform 8 [Canis familiaris].
          Length = 402

 Score =  161 bits (407), Expect = 1e-39
 Identities = 103/299 (34%), Positives = 150/299 (50%), Gaps = 37/299 (12%)
 Frame = +2

Query: 230  LLKDSIVQLCTARPERPMAFLREYFERLEKEEAKQIQNLQKASARADSREDEISPPPP-- 403
            LL+   V++   +P   + F  ++F RL++E  +          R  +  D  +PP P  
Sbjct: 12   LLQGFTVEVLRHQPADLLDFALQHFTRLQQENER----------RGPASPDPAAPPQPAA 61

Query: 404  ---------------------------NPVVKGRRRRGAISAEVYT----EEDAASYVRK 490
                                        PV+    RR ++ AE Y     E+DA S  R 
Sbjct: 62   RRPPPTPQPTERAQAGGEAEGEGDSLLTPVINRFTRRASVCAEAYNPDEEEDDAES--RI 119

Query: 491  VIPKDYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFPVSFIAGETVIQQGDEGDNFYV 670
            + PK       L +A +  +LF +LD  + S + DAMF      GE VI QGD+GDNFYV
Sbjct: 120  IHPKTDDQRNRLQEACKDILLFKNLDPEQMSQVLDAMFEKLVKEGEHVIDQGDDGDNFYV 179

Query: 671  IDQGEMDVYVN----NEWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYR 838
            ID+G  D+YV          +    GSFGELAL+Y TPRAAT+ A +   LWG+DR ++R
Sbjct: 180  IDRGTFDIYVKCDGVGRCVGNYDNRGSFGELALMYNTPRAATITATSPGALWGLDRVTFR 239

Query: 839  RILMGSTLRKRKMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEQGTS 1015
            RI++ +  +KRKMYE F+  +  L+SL+  ERL V D +    + DG++I+ QG+   S
Sbjct: 240  RIIVKNNAKKRKMYESFIESLPFLKSLEVSERLKVVDVIGTKVYNDGEQIIAQGDSADS 298



 Score = 62.0 bits (149), Expect = 9e-10
 Identities = 45/154 (29%), Positives = 70/154 (45%), Gaps = 12/154 (7%)
 Frame = +2

Query: 467 DAASYVRKVIPKDYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFPVSFIAGETVIQQG 646
           D  ++ R ++  + K        IE       L+ +ER  + D +    +  GE +I QG
Sbjct: 234 DRVTFRRIIVKNNAKKRKMYESFIESLPFLKSLEVSERLKVVDVIGTKVYNDGEQIIAQG 293

Query: 647 DEGDNFYVIDQGEM------DVYVNNEWATSV---GEGGSFGELALIYGTPRAATVKAKT 799
           D  D+F++++ GE+       V V  + A  +     G  FGELAL+   PRAA+  A  
Sbjct: 294 DSADSFFIVESGEVKITMKRKVKVEEDGAVEIARCSRGQYFGELALVTNKPRAASAHAIG 353

Query: 800 NVKLWGIDRDSYRRIL---MGSTLRKRKMYEEFL 892
            VK   +D  ++ R+L   M    R    YEE L
Sbjct: 354 TVKCLAMDVQAFERLLGPCMEIMKRNIATYEEQL 387


  Database: RefSeq49_CP.fasta
    Posted date:  Oct 17, 2011  1:42 PM
  Number of letters in database: 18,874,504
  Number of sequences in database:  33,336
  
Lambda     K      H
   0.318    0.134    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 33336
Number of Hits to DB: 41,918,598
Number of extensions: 1123007
Number of successful extensions: 4712
Number of sequences better than 1.0e-05: 25
Number of HSP's gapped: 4614
Number of HSP's successfully gapped: 40
Length of query: 351
Length of database: 18,874,504
Length adjustment: 104
Effective length of query: 247
Effective length of database: 15,407,560
Effective search space: 3805667320
Effective search space used: 3805667320
Neighboring words threshold: 12
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 35 (18.1 bits)

BLASTX 2.2.24 [Aug-08-2010]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= 20110601C-007684
         (1055 letters)

Database: RefSeq49_MP.fasta 
           30,036 sequences; 15,617,559 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

Alignment   gi|NP_068680.1| cAMP-dependent protein kinase type I-alpha regu...   518   e-147
Alignment   gi|NP_032949.3| cAMP-dependent protein kinase type I-beta regul...   452   e-127
Alignment   gi|NP_032950.1| cAMP-dependent protein kinase type II-alpha reg...   160   2e-39
Alignment   gi|NP_035288.2| cAMP-dependent protein kinase type II-beta regu...   157   1e-38
Alignment   gi|NP_035290.1| cGMP-dependent protein kinase 1 beta isoform [M...   120   1e-27
Alignment   gi|NP_001013855.1| cGMP-dependent protein kinase 1 alpha isofor...   120   2e-27
Alignment   gi|NP_032952.3| cGMP-dependent protein kinase 2 [Mus musculus].      112   5e-25
Alignment   gi|NP_001171282.1| rap guanine nucleotide exchange factor 3 iso...    54   2e-07
Alignment   gi|NP_001171281.1| rap guanine nucleotide exchange factor 3 iso...    54   2e-07
Alignment   gi|NP_659099.2| rap guanine nucleotide exchange factor 3 isofor...    54   2e-07

>ref|NP_068680.1| cAMP-dependent protein kinase type I-alpha regulatory subunit [Mus
            musculus].
          Length = 381

 Score =  518 bits (1335), Expect = e-147
 Identities = 267/289 (92%), Positives = 268/289 (92%), Gaps = 1/289 (0%)
 Frame = +2

Query: 146  MASGSTAXXXXXXXXXXXX-YVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKE 322
            MASGS A             YVQKHNIQALLKDSIVQLCT RPERPMAFLREYFERLEKE
Sbjct: 1    MASGSMATSEEERSLRECELYVQKHNIQALLKDSIVQLCTTRPERPMAFLREYFERLEKE 60

Query: 323  EAKQIQNLQKASARADSREDEISPPPPNPVVKGRRRRGAISAEVYTEEDAASYVRKVIPK 502
            EA+QIQ LQK   R DSREDEISPPPPNPVVKGRRRRGAISAEVYTEEDAASYVRKVIPK
Sbjct: 61   EARQIQCLQKTGIRTDSREDEISPPPPNPVVKGRRRRGAISAEVYTEEDAASYVRKVIPK 120

Query: 503  DYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFPVSFIAGETVIQQGDEGDNFYVIDQG 682
            DYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFPVSFIAGETVIQQGDEGDNFYVIDQG
Sbjct: 121  DYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFPVSFIAGETVIQQGDEGDNFYVIDQG 180

Query: 683  EMDVYVNNEWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTL 862
            EMDVYVNNEWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTL
Sbjct: 181  EMDVYVNNEWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTL 240

Query: 863  RKRKMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEQG 1009
            RKRKMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGE G
Sbjct: 241  RKRKMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEPG 289



 Score = 69.3 bits (168), Expect = 5e-12
 Identities = 51/152 (33%), Positives = 76/152 (50%), Gaps = 9/152 (5%)
 Frame = +2

Query: 467 DAASYVRKVIPKDYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFPVSFIAGETVIQQG 646
           D  SY R ++    +      + + K  +   LD  ER  + DA+ PV F  G+ ++ QG
Sbjct: 227 DRDSYRRILMGSTLRKRKMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQG 286

Query: 647 DEGDNFYVIDQGEMDVY---VNNEWATSVGEGGS---FGELALIYGTPRAATVKAKTNVK 808
           + GD F++I +G   V      NE    VG  G    FGE+AL+   PRAATV A+  +K
Sbjct: 287 EPGDEFFIILEGTAAVLQRRSENEEFVEVGRLGPSDYFGEIALLMNRPRAATVVARGPLK 346

Query: 809 LWGIDRDSYRRIL-MGSTLRKR--KMYEEFLS 895
              +DR  + R+L   S + KR  + Y  F+S
Sbjct: 347 CVKLDRPRFERVLGPCSDILKRNIQQYNSFVS 378


>ref|NP_032949.3| cAMP-dependent protein kinase type I-beta regulatory subunit [Mus
            musculus].
          Length = 381

 Score =  452 bits (1162), Expect = e-127
 Identities = 221/269 (82%), Positives = 245/269 (91%)
 Frame = +2

Query: 203  YVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKEEAKQIQNLQKASARADSRED 382
            YVQKH IQ +LK+ IV LC A+P+RP+ FLRE+FE+LEKEE +QI   QK++++ DS ++
Sbjct: 21   YVQKHGIQQVLKECIVHLCVAKPDRPLRFLREHFEKLEKEENRQILARQKSNSQCDSHDE 80

Query: 383  EISPPPPNPVVKGRRRRGAISAEVYTEEDAASYVRKVIPKDYKTMAALAKAIEKNVLFSH 562
            EISP PPNPVVK RRRRG +SAEVYTEEDA SYVRKVIPKDYKTM ALAKAI KNVLFSH
Sbjct: 81   EISPTPPNPVVKARRRRGGVSAEVYTEEDAVSYVRKVIPKDYKTMTALAKAISKNVLFSH 140

Query: 563  LDDNERSDIFDAMFPVSFIAGETVIQQGDEGDNFYVIDQGEMDVYVNNEWATSVGEGGSF 742
            LDDNERSDIFDAMFPV+ I GETVIQQG+EGDNFYVIDQGE+DVYVN EW T++ EGGSF
Sbjct: 141  LDDNERSDIFDAMFPVTHIGGETVIQQGNEGDNFYVIDQGEVDVYVNGEWVTNISEGGSF 200

Query: 743  GELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSILESLD 922
            GELALIYGTPRAATVKAKT++KLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSILESL+
Sbjct: 201  GELALIYGTPRAATVKAKTDLKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSILESLE 260

Query: 923  KWERLTVADALEPVQFEDGQKIVVQGEQG 1009
            KWERLTVADALEPVQFEDG+KIVVQGE G
Sbjct: 261  KWERLTVADALEPVQFEDGEKIVVQGEPG 289



 Score = 73.2 bits (178), Expect = 3e-13
 Identities = 52/152 (34%), Positives = 77/152 (50%), Gaps = 9/152 (5%)
 Frame = +2

Query: 467 DAASYVRKVIPKDYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFPVSFIAGETVIQQG 646
           D  SY R ++    +      + + K  +   L+  ER  + DA+ PV F  GE ++ QG
Sbjct: 227 DRDSYRRILMGSTLRKRKMYEEFLSKVSILESLEKWERLTVADALEPVQFEDGEKIVVQG 286

Query: 647 DEGDNFYVIDQGEMDVYVN---NEWATSVGEGGS---FGELALIYGTPRAATVKAKTNVK 808
           + GD+FY+I +G   V      NE    VG  G    FGE+AL+   PRAATV A+  +K
Sbjct: 287 EPGDDFYIITEGTASVLQRRSPNEEYVEVGRLGPSDYFGEIALLLNRPRAATVVARGPLK 346

Query: 809 LWGIDRDSYRRIL-MGSTLRKRKM--YEEFLS 895
              +DR  + R+L   S + KR +  Y  F+S
Sbjct: 347 CVKLDRPRFERVLGPCSEILKRNIQRYNSFIS 378


>ref|NP_032950.1| cAMP-dependent protein kinase type II-alpha regulatory subunit [Mus
            musculus].
          Length = 402

 Score =  160 bits (404), Expect = 2e-39
 Identities = 101/287 (35%), Positives = 158/287 (55%), Gaps = 25/287 (8%)
 Frame = +2

Query: 230  LLKDSIVQLCTARPERPMAFLREYFERLEKEEAKQIQNL---------QKASA------- 361
            LL+   V++   +P   + F  EYF RL +   ++             Q++SA       
Sbjct: 13   LLQGYTVEVLRQQPPDLVDFAVEYFTRLREARRQESDTFIVSPTTFHTQESSAVPVIEED 72

Query: 362  ---RADSREDEISPPPPNPVVKGRRRRGAISAEVYT--EEDAASYVRKVIPKDYKTMAAL 526
                +DS + ++  P P+       RR ++ AE +   EE+  +  R V PK  +    L
Sbjct: 73   GESDSDSEDADLEVPVPSKFT----RRVSVCAETFNPDEEEEDNDPRVVHPKTDEQRCRL 128

Query: 527  AKAIEKNVLFSHLDDNERSDIFDAMFPVSFIAGETVIQQGDEGDNFYVIDQGEMDVYVNN 706
             +A +  +LF +LD  + S + DAMF       E VI QGD+GDNFYVI++G  D+ V  
Sbjct: 129  QEACKDILLFKNLDQEQLSQVLDAMFEKIVKTDEHVIDQGDDGDNFYVIERGTYDILVTK 188

Query: 707  EWAT-SVGE---GGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTLRKRK 874
            +  T SVG+    GSFGELAL+Y TPRAAT+ A +   LWG+DR ++RRI++ +  +KRK
Sbjct: 189  DNQTRSVGQYDNRGSFGELALMYNTPRAATIIATSEGSLWGLDRVTFRRIIVKNNAKKRK 248

Query: 875  MYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEQGTS 1015
            M+E F+  V + +SL+  ER+ + D +    ++DG++I+ QGE+  S
Sbjct: 249  MFESFIESVPLFKSLEMSERMKIVDVIGEKIYKDGERIIAQGEKADS 295



 Score = 69.7 bits (169), Expect = 4e-12
 Identities = 47/160 (29%), Positives = 77/160 (48%), Gaps = 15/160 (9%)
 Frame = +2

Query: 467 DAASYVRKVIPKDYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFPVSFIAGETVIQQG 646
           D  ++ R ++  + K        IE   LF  L+ +ER  I D +    +  GE +I QG
Sbjct: 231 DRVTFRRIIVKNNAKKRKMFESFIESVPLFKSLEMSERMKIVDVIGEKIYKDGERIIAQG 290

Query: 647 DEGDNFYVIDQGEMDVYVNNEWATSVGEGGS------------FGELALIYGTPRAATVK 790
           ++ D+FY+I+ GE+ + + ++  ++   G              FGELAL+   PRAA+  
Sbjct: 291 EKADSFYIIESGEVSILIRSKTKSNKNGGNQEVEIAHCHKGQYFGELALVTNKPRAASAY 350

Query: 791 AKTNVKLWGIDRDSYRRIL---MGSTLRKRKMYEEFLSKV 901
           A  +VK   +D  ++ R+L   M    R    YEE L K+
Sbjct: 351 AVGDVKCLVMDVQAFERLLGPCMDIMKRNISHYEEQLVKM 390


>ref|NP_035288.2| cAMP-dependent protein kinase type II-beta regulatory subunit [Mus
            musculus].
          Length = 416

 Score =  157 bits (398), Expect = 1e-38
 Identities = 89/211 (42%), Positives = 124/211 (58%), Gaps = 8/211 (3%)
 Frame = +2

Query: 407  PVVKGRRRRGAISAEVYT----EEDAASYVRKVIPKDYKTMAALAKAIEKNVLFSHLDDN 574
            PV+    RR ++ AE Y     E+DA S  R + PK       L +A +  +LF +LD  
Sbjct: 102  PVINRFTRRASVCAEAYNPDEEEDDAES--RIIHPKTDDQRNRLQEACKDILLFKNLDPE 159

Query: 575  ERSDIFDAMFPVSFIAGETVIQQGDEGDNFYVIDQGEMDVYVN----NEWATSVGEGGSF 742
            + S + DAMF      GE VI QGD+GDNFYVID+G  D+YV          +    GSF
Sbjct: 160  QMSQVLDAMFEKLVKEGEHVIDQGDDGDNFYVIDRGTFDIYVKCDGVGRCVGNYDNRGSF 219

Query: 743  GELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSILESLD 922
            GELAL+Y TPRAAT+ A +   LWG+DR ++RRI++ +  +KRKMYE F+  +  L+SL+
Sbjct: 220  GELALMYNTPRAATITATSPGALWGLDRVTFRRIIVKNNAKKRKMYESFIESLPFLKSLE 279

Query: 923  KWERLTVADALEPVQFEDGQKIVVQGEQGTS 1015
              ERL V D +    + DG++I+ QG+   S
Sbjct: 280  VSERLKVVDVIGTKVYNDGEQIIAQGDLADS 310



 Score = 64.3 bits (155), Expect = 2e-10
 Identities = 44/156 (28%), Positives = 72/156 (46%), Gaps = 14/156 (8%)
 Frame = +2

Query: 467 DAASYVRKVIPKDYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFPVSFIAGETVIQQG 646
           D  ++ R ++  + K        IE       L+ +ER  + D +    +  GE +I QG
Sbjct: 246 DRVTFRRIIVKNNAKKRKMYESFIESLPFLKSLEVSERLKVVDVIGTKVYNDGEQIIAQG 305

Query: 647 DEGDNFYVIDQGEMDVYVNNEWATSVGEGGS-----------FGELALIYGTPRAATVKA 793
           D  D+F++++ GE+ + +  +  + V E G+           FGELAL+   PRAA+  A
Sbjct: 306 DLADSFFIVESGEVKITMKRKGKSEVEENGAVEIARCFRGQYFGELALVTNKPRAASAHA 365

Query: 794 KTNVKLWGIDRDSYRRIL---MGSTLRKRKMYEEFL 892
              VK   +D  ++ R+L   M    R    YEE L
Sbjct: 366 IGTVKCLAMDVQAFERLLGPCMEIMKRNIATYEEQL 401


>ref|NP_035290.1| cGMP-dependent protein kinase 1 beta isoform [Mus musculus].
          Length = 686

 Score =  120 bits (302), Expect = 1e-27
 Identities = 76/240 (31%), Positives = 122/240 (50%), Gaps = 2/240 (0%)
 Frame = +2

Query: 296  EYFERLEKEEAKQIQNLQKASARADSREDEISPPPPNPVVKGRRRRGAISAE--VYTEED 469
            E  ++L+ E  K    ++ A+ +A  +        P      R +R AISAE   +  +D
Sbjct: 37   ELIQKLQNELDKYRSVIRPATQQAQKQSASTLQGEP------RTKRQAISAEPTAFDIQD 90

Query: 470  AASYVRKVIPKDYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFPVSFIAGETVIQQGD 649
             +       PK  ++   + +AI  N    +L+ ++  +I D M+PV +     +I++GD
Sbjct: 91   LSHVTLPFYPKSPQSKDLIKEAILDNDFMKNLELSQIQEIVDCMYPVEYGKDSCIIKEGD 150

Query: 650  EGDNFYVIDQGEMDVYVNNEWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRD 829
             G   YV++ G+++V        ++G G  FGELA++Y   R ATVK   NVKLW IDR 
Sbjct: 151  VGSLVYVMEDGKVEVTKEGVKLCTMGPGKVFGELAILYNCTRTATVKTLVNVKLWAIDRQ 210

Query: 830  SYRRILMGSTLRKRKMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEQG 1009
             ++ I+M + L K   Y EFL  V   +SL       +AD LE   +E+G+ I+ QG +G
Sbjct: 211  CFQTIMMRTGLIKHTEYMEFLKSVPTFQSLPDEILSKLADVLEETHYENGEYIIRQGARG 270



 Score = 57.0 bits (136), Expect = 2e-08
 Identities = 38/121 (31%), Positives = 60/121 (49%), Gaps = 6/121 (4%)
 Frame = +2

Query: 554 FSHLDDNERSDIFDAMFPVSFIAGETVIQQGDEGDNFYVIDQGEMDVYVNNE------WA 715
           F  L D   S + D +    +  GE +I+QG  GD F++I +G+++V   +       + 
Sbjct: 237 FQSLPDEILSKLADVLEETHYENGEYIIRQGARGDTFFIISKGQVNVTREDSPSEDPVFL 296

Query: 716 TSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTLRKRKMYEEFLS 895
            ++G+G  FGE AL     R A V A   V    IDRDS++ ++ G      K YE+  +
Sbjct: 297 RTLGKGDWFGEKALQGEDVRTANVIAAEAVTCLVIDRDSFKHLIGGLDDVSNKAYEDAEA 356

Query: 896 K 898
           K
Sbjct: 357 K 357


>ref|NP_001013855.1| cGMP-dependent protein kinase 1 alpha isoform [Mus musculus].
          Length = 671

 Score =  120 bits (301), Expect = 2e-27
 Identities = 82/262 (31%), Positives = 133/262 (50%), Gaps = 3/262 (1%)
 Frame = +2

Query: 233  LKDSIVQLCTARPERPMAFLREYFERLEKEEAKQIQNLQKASARADSREDEISPPPPNPV 412
            L++   ++   + ER    ++E  +RL ++E ++IQ L++   +  S    + P P   +
Sbjct: 4    LEEDFAKILMLKEER----IKELEKRLSEKE-EEIQELKRKLHKCQS----VLPVPSTHI 54

Query: 413  VKGRRRRGAISAEVYTEE---DAASYVRKVIPKDYKTMAALAKAIEKNVLFSHLDDNERS 583
                 R   ISAE  T     D     RK   K  ++   + +AI  N    +L+ ++  
Sbjct: 55   GPRTTRAQGISAEPQTYRSFHDLRQAFRK-FTKSERSKDLIKEAILDNDFMKNLELSQIQ 113

Query: 584  DIFDAMFPVSFIAGETVIQQGDEGDNFYVIDQGEMDVYVNNEWATSVGEGGSFGELALIY 763
            +I D M+PV +     +I++GD G   YV++ G+++V        ++G G  FGELA++Y
Sbjct: 114  EIVDCMYPVEYGKDSCIIKEGDVGSLVYVMEDGKVEVTKEGVKLCTMGPGKVFGELAILY 173

Query: 764  GTPRAATVKAKTNVKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSILESLDKWERLTV 943
               R ATVK   NVKLW IDR  ++ I+M + L K   Y EFL  V   +SL       +
Sbjct: 174  NCTRTATVKTLVNVKLWAIDRQCFQTIMMRTGLIKHTEYMEFLKSVPTFQSLPDEILSKL 233

Query: 944  ADALEPVQFEDGQKIVVQGEQG 1009
            AD LE   +E+G+ I+ QG +G
Sbjct: 234  ADVLEETHYENGEYIIRQGARG 255



 Score = 57.0 bits (136), Expect = 2e-08
 Identities = 38/121 (31%), Positives = 60/121 (49%), Gaps = 6/121 (4%)
 Frame = +2

Query: 554 FSHLDDNERSDIFDAMFPVSFIAGETVIQQGDEGDNFYVIDQGEMDVYVNNE------WA 715
           F  L D   S + D +    +  GE +I+QG  GD F++I +G+++V   +       + 
Sbjct: 222 FQSLPDEILSKLADVLEETHYENGEYIIRQGARGDTFFIISKGQVNVTREDSPSEDPVFL 281

Query: 716 TSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTLRKRKMYEEFLS 895
            ++G+G  FGE AL     R A V A   V    IDRDS++ ++ G      K YE+  +
Sbjct: 282 RTLGKGDWFGEKALQGEDVRTANVIAAEAVTCLVIDRDSFKHLIGGLDDVSNKAYEDAEA 341

Query: 896 K 898
           K
Sbjct: 342 K 342


>ref|NP_032952.3| cGMP-dependent protein kinase 2 [Mus musculus].
          Length = 762

 Score =  112 bits (280), Expect = 5e-25
 Identities = 76/272 (27%), Positives = 137/272 (50%), Gaps = 30/272 (11%)
 Frame = +2

Query: 290  LREYFERLEKEE---AKQIQNLQKASARADSREDEI-----SPPPPNP------------ 409
            L+E  E+L K+    A+  + LQ    + +  +D I     SP   +P            
Sbjct: 51   LKELREQLAKQTVAIAELTEELQSKCIQLNKLQDVIHVQGGSPLQASPDKVPLDVHRKTS 110

Query: 410  -VVKGRRRRGA---ISAEVYT------EEDAASYVRKVIPKDYKTMAALAKAIEKNVLFS 559
             +V    RRGA   +SAE  T      +    S+ +  + KD      +  A+ KN    
Sbjct: 111  GLVSLHSRRGAKAGVSAEPTTRTYDLNKPPEFSFEKARVRKDSSEKKLITDALNKNQFLK 170

Query: 560  HLDDNERSDIFDAMFPVSFIAGETVIQQGDEGDNFYVIDQGEMDVYVNNEWATSVGEGGS 739
             LD  +  D+ + M+  ++  G  VI+QG+ G++ +V+ +G ++V+   +  +S+    +
Sbjct: 171  RLDPQQIKDMVECMYGRNYQQGSYVIKQGEPGNHIFVLAEGRLEVFQGEKLLSSIPMWTT 230

Query: 740  FGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSILESL 919
            FGELA++Y   R A+VKA TNVK W +DR+ ++ I+  +   + + Y  FL  VS+L++L
Sbjct: 231  FGELAILYNCTRTASVKAITNVKTWALDREVFQNIMRRTAQARDEEYRNFLRSVSLLKNL 290

Query: 920  DKWERLTVADALEPVQFEDGQKIVVQGEQGTS 1015
             + +   + D LE   ++ G  I+ +GE+G++
Sbjct: 291  PEDKLTKIIDCLEVEYYDKGDYIIREGEEGST 322


>ref|NP_001171282.1| rap guanine nucleotide exchange factor 3 isoform 3 [Mus musculus].
          Length = 909

 Score = 54.3 bits (129), Expect = 2e-07
 Identities = 35/122 (28%), Positives = 66/122 (54%), Gaps = 3/122 (2%)
 Frame = +2

Query: 557 SHLDDNERSDIFDAM-FPVSFIAGETVIQQGDEGDNFYVIDQGEMDVYVNNEW-ATSVGE 730
           +HL ++ + ++   + F     AG  +  QGD+G ++Y+I +G ++V  + +   T++ E
Sbjct: 247 AHLSNSVKRELAAVLLFEPHSKAGTVLFSQGDKGTSWYIIWKGSVNVVTHGKGLVTTLHE 306

Query: 731 GGSFGELALIYGTPRAAT-VKAKTNVKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSI 907
           G  FG+LAL+   PRAAT +  + N     +D+  + RI+     +  ++ EE    V +
Sbjct: 307 GDDFGQLALVNDAPRAATIILRENNCHFLRVDKQDFNRIIKDVEAKTMRL-EEHGKVVLV 365

Query: 908 LE 913
           LE
Sbjct: 366 LE 367


>ref|NP_001171281.1| rap guanine nucleotide exchange factor 3 isoform 1 [Mus musculus].
          Length = 926

 Score = 54.3 bits (129), Expect = 2e-07
 Identities = 35/122 (28%), Positives = 66/122 (54%), Gaps = 3/122 (2%)
 Frame = +2

Query: 557 SHLDDNERSDIFDAM-FPVSFIAGETVIQQGDEGDNFYVIDQGEMDVYVNNEW-ATSVGE 730
           +HL ++ + ++   + F     AG  +  QGD+G ++Y+I +G ++V  + +   T++ E
Sbjct: 247 AHLSNSVKRELAAVLLFEPHSKAGTVLFSQGDKGTSWYIIWKGSVNVVTHGKGLVTTLHE 306

Query: 731 GGSFGELALIYGTPRAAT-VKAKTNVKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSI 907
           G  FG+LAL+   PRAAT +  + N     +D+  + RI+     +  ++ EE    V +
Sbjct: 307 GDDFGQLALVNDAPRAATIILRENNCHFLRVDKQDFNRIIKDVEAKTMRL-EEHGKVVLV 365

Query: 908 LE 913
           LE
Sbjct: 366 LE 367


>ref|NP_659099.2| rap guanine nucleotide exchange factor 3 isoform 2 [Mus musculus].
          Length = 918

 Score = 54.3 bits (129), Expect = 2e-07
 Identities = 35/122 (28%), Positives = 66/122 (54%), Gaps = 3/122 (2%)
 Frame = +2

Query: 557 SHLDDNERSDIFDAM-FPVSFIAGETVIQQGDEGDNFYVIDQGEMDVYVNNEW-ATSVGE 730
           +HL ++ + ++   + F     AG  +  QGD+G ++Y+I +G ++V  + +   T++ E
Sbjct: 247 AHLSNSVKRELAAVLLFEPHSKAGTVLFSQGDKGTSWYIIWKGSVNVVTHGKGLVTTLHE 306

Query: 731 GGSFGELALIYGTPRAAT-VKAKTNVKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSI 907
           G  FG+LAL+   PRAAT +  + N     +D+  + RI+     +  ++ EE    V +
Sbjct: 307 GDDFGQLALVNDAPRAATIILRENNCHFLRVDKQDFNRIIKDVEAKTMRL-EEHGKVVLV 365

Query: 908 LE 913
           LE
Sbjct: 366 LE 367


  Database: RefSeq49_MP.fasta
    Posted date:  Oct 17, 2011  1:42 PM
  Number of letters in database: 15,617,559
  Number of sequences in database:  30,036
  
Lambda     K      H
   0.318    0.134    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 30036
Number of Hits to DB: 34,964,161
Number of extensions: 931031
Number of successful extensions: 3563
Number of sequences better than 1.0e-05: 13
Number of HSP's gapped: 3523
Number of HSP's successfully gapped: 19
Length of query: 351
Length of database: 15,617,559
Length adjustment: 102
Effective length of query: 249
Effective length of database: 12,553,887
Effective search space: 3125917863
Effective search space used: 3125917863
Neighboring words threshold: 12
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 34 (17.7 bits)

BLASTX 2.2.24 [Aug-08-2010]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= 20110601C-007684
         (1055 letters)

Database: RefSeq49_SP.fasta 
           24,897 sequences; 11,343,932 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

Alignment   gi|NP_999191.1| cAMP-dependent protein kinase type I-alpha regu...   535   e-152
Alignment   gi|XP_003124299.2| PREDICTED: cAMP-dependent protein kinase typ...   318   4e-87
Alignment   gi|NP_999423.2| cAMP-dependent protein kinase type II-alpha reg...   162   3e-40
Alignment   gi|XP_003130314.2| PREDICTED: cAMP-dependent protein kinase typ...   157   7e-39
Alignment   gi|NP_001038039.1| cGMP-dependent protein kinase 1 [Sus scrofa].     121   7e-28
Alignment   gi|XP_003129412.2| PREDICTED: cGMP-dependent protein kinase 2 [...   110   1e-24
Alignment   gi|XP_003133536.2| PREDICTED: rap guanine nucleotide exchange f...    53   2e-07

>ref|NP_999191.1| cAMP-dependent protein kinase type I-alpha regulatory subunit [Sus
            scrofa].
          Length = 380

 Score =  535 bits (1379), Expect = e-152
 Identities = 274/288 (95%), Positives = 274/288 (95%)
 Frame = +2

Query: 146  MASGSTAXXXXXXXXXXXXYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKEE 325
            MASGSTA            YVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKEE
Sbjct: 1    MASGSTASEEERSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKEE 60

Query: 326  AKQIQNLQKASARADSREDEISPPPPNPVVKGRRRRGAISAEVYTEEDAASYVRKVIPKD 505
            AKQIQNLQKASARADSREDEISPPPPNPVVKGRRRRGAISAEVYTEEDAASYVRKVIPKD
Sbjct: 61   AKQIQNLQKASARADSREDEISPPPPNPVVKGRRRRGAISAEVYTEEDAASYVRKVIPKD 120

Query: 506  YKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFPVSFIAGETVIQQGDEGDNFYVIDQGE 685
            YKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFPVSFIAGETVIQQGDEGDNFYVIDQGE
Sbjct: 121  YKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFPVSFIAGETVIQQGDEGDNFYVIDQGE 180

Query: 686  MDVYVNNEWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTLR 865
            MDVYVNNEWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWG DRDSYRRILMGSTLR
Sbjct: 181  MDVYVNNEWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGNDRDSYRRILMGSTLR 240

Query: 866  KRKMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEQG 1009
            KRKMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGE G
Sbjct: 241  KRKMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEPG 288



 Score = 70.5 bits (171), Expect = 2e-12
 Identities = 54/174 (31%), Positives = 84/174 (48%), Gaps = 12/174 (6%)
 Frame = +2

Query: 410 VVKGRRRRGAISAEVYTE---EDAASYVRKVIPKDYKTMAALAKAIEKNVLFSHLDDNER 580
           ++ G  R   + A+   +    D  SY R ++    +      + + K  +   LD  ER
Sbjct: 204 LIYGTPRAATVKAKTNVKLWGNDRDSYRRILMGSTLRKRKMYEEFLSKVSILESLDKWER 263

Query: 581 SDIFDAMFPVSFIAGETVIQQGDEGDNFYVIDQGEMDVY---VNNEWATSVGEGGS---F 742
             + DA+ PV F  G+ ++ QG+ GD F++I +G   V      NE    VG  G    F
Sbjct: 264 LTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSAAVLQRRSENEEFVEVGRLGPSDYF 323

Query: 743 GELALIYGTPRAATVKAKTNVKLWGIDRDSYRRIL-MGSTLRKR--KMYEEFLS 895
           GE+AL+   PRAATV A+  +K   +DR  + R+L   S + KR  + Y  F+S
Sbjct: 324 GEIALLMNRPRAATVVARGPLKCVKLDRPRFERVLGPCSDILKRNIQQYNSFVS 377


>ref|XP_003124299.2| PREDICTED: cAMP-dependent protein kinase type I-beta regulatory
            subunit-like [Sus scrofa].
          Length = 324

 Score =  318 bits (814), Expect = 4e-87
 Identities = 154/176 (87%), Positives = 168/176 (95%)
 Frame = +2

Query: 482  VRKVIPKDYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFPVSFIAGETVIQQGDEGDN 661
            + KVIPKDYKTM ALA+AI KNVLF+HLDDNERSDIFDAMFPV+ IAGETVIQQGDEGDN
Sbjct: 57   LEKVIPKDYKTMTALARAISKNVLFAHLDDNERSDIFDAMFPVTHIAGETVIQQGDEGDN 116

Query: 662  FYVIDQGEMDVYVNNEWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRR 841
            FYV+DQGE+DVYVN EW TS+ EGGSFGELALIYGTPRAATVKAKT++KLWGIDRDSYRR
Sbjct: 117  FYVVDQGEVDVYVNGEWVTSISEGGSFGELALIYGTPRAATVKAKTDLKLWGIDRDSYRR 176

Query: 842  ILMGSTLRKRKMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEQG 1009
            ILMGSTLRKR++Y+EFLSKVSILESL+KWERLTVADALEPVQFEDG+KIVVQGE G
Sbjct: 177  ILMGSTLRKRRVYQEFLSKVSILESLEKWERLTVADALEPVQFEDGEKIVVQGEPG 232



 Score = 72.0 bits (175), Expect = 5e-13
 Identities = 51/152 (33%), Positives = 77/152 (50%), Gaps = 9/152 (5%)
 Frame = +2

Query: 467 DAASYVRKVIPKDYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFPVSFIAGETVIQQG 646
           D  SY R ++    +      + + K  +   L+  ER  + DA+ PV F  GE ++ QG
Sbjct: 170 DRDSYRRILMGSTLRKRRVYQEFLSKVSILESLEKWERLTVADALEPVQFEDGEKIVVQG 229

Query: 647 DEGDNFYVIDQGEMDVYVN---NEWATSVGEGGS---FGELALIYGTPRAATVKAKTNVK 808
           + GD+F++I +G   V      NE    VG  G    FGE+AL+   PRAATV A+  +K
Sbjct: 230 EPGDDFFIITEGTASVLQRRSPNEEYVEVGRLGPSDYFGEIALLLNRPRAATVVARGPLK 289

Query: 809 LWGIDRDSYRRIL-MGSTLRKRKM--YEEFLS 895
              +DR  + R+L   S + KR +  Y  F+S
Sbjct: 290 CVKLDRPRFERVLGPCSEILKRNIQRYNSFIS 321



 Score = 65.1 bits (157), Expect = 6e-11
 Identities = 33/58 (56%), Positives = 42/58 (72%)
 Frame = +2

Query: 203 YVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKEEAKQIQNLQKASARADSR 376
           YVQKH +Q +LKD IVQLC ++P RPM FLRE+FE+LEK   K  + +  A ARA S+
Sbjct: 21  YVQKHGVQQVLKDCIVQLCVSKPARPMKFLREHFEKLEKVIPKDYKTM-TALARAISK 77


>ref|NP_999423.2| cAMP-dependent protein kinase type II-alpha regulatory subunit [Sus
            scrofa].
          Length = 401

 Score =  162 bits (410), Expect = 3e-40
 Identities = 104/283 (36%), Positives = 160/283 (56%), Gaps = 21/283 (7%)
 Frame = +2

Query: 230  LLKDSIVQLCTARPERPMAFLREYFERLEKEEAKQI----------QNLQKAS-----AR 364
            LL+   V++   +P   + F  +YF RL +  ++            Q+L+ +S     A 
Sbjct: 13   LLQGYTVEVLRRQPPDLVDFAVDYFTRLREARSRASTPPAAPPSGSQDLEPSSGLVTDAI 72

Query: 365  ADSREDEISPPPPNPVVKGRRRRGAISAEVYT--EEDAASYVRKVIPKDYKTMAALAKAI 538
            ADS E E       P+     RR ++ AE Y   EE+  +  R + PK  +    L +A 
Sbjct: 73   ADS-ESEDDEDLDVPIPSRFDRRVSVCAETYNPDEEEEDTDPRVIHPKTDQQRCRLQEAC 131

Query: 539  EKNVLFSHLDDNERSDIFDAMFPVSFIAGETVIQQGDEGDNFYVIDQGEMDVYVNNEWAT 718
            +  +LF +LD  + S + DAMF  +    E VI QGD+GDNFYVI++G  D+ V  +  T
Sbjct: 132  KDILLFKNLDQEQLSQVLDAMFERTVKVDEHVIDQGDDGDNFYVIERGTYDILVTKDNQT 191

Query: 719  -SVGE---GGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTLRKRKMYEE 886
             SVG+    GSFGELAL+Y TPRAAT+ A +   LWG+DR ++RRI++ +  +KRKM+E 
Sbjct: 192  RSVGQYDNHGSFGELALMYNTPRAATIVATSEGSLWGLDRVTFRRIIVKNNAKKRKMFES 251

Query: 887  FLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEQGTS 1015
            F+  V +L+SL+  ER+ + D +    ++DG++I+ QGE+  S
Sbjct: 252  FIESVPLLKSLEVSERMKIVDVIGEKIYKDGERIITQGEKADS 294



 Score = 66.6 bits (161), Expect = 2e-11
 Identities = 46/160 (28%), Positives = 75/160 (46%), Gaps = 15/160 (9%)
 Frame = +2

Query: 467 DAASYVRKVIPKDYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFPVSFIAGETVIQQG 646
           D  ++ R ++  + K        IE   L   L+ +ER  I D +    +  GE +I QG
Sbjct: 230 DRVTFRRIIVKNNAKKRKMFESFIESVPLLKSLEVSERMKIVDVIGEKIYKDGERIITQG 289

Query: 647 DEGDNFYVIDQGEMDVYVNNEWATSVGEGGS------------FGELALIYGTPRAATVK 790
           ++ D+FY+I+ GE+ + + ++   +   G              FGELAL+   PRAA+  
Sbjct: 290 EKADSFYIIESGEVSILIKSKTKANKDGGNQEVEIARCHKGQYFGELALVTNKPRAASAY 349

Query: 791 AKTNVKLWGIDRDSYRRIL---MGSTLRKRKMYEEFLSKV 901
           A  +VK   +D  ++ R+L   M    R    YEE L K+
Sbjct: 350 AVGDVKCLVMDVQAFERLLGPCMDIMKRNISHYEEQLVKM 389


>ref|XP_003130314.2| PREDICTED: cAMP-dependent protein kinase type II-beta regulatory
            subunit [Sus scrofa].
          Length = 359

 Score =  157 bits (398), Expect = 7e-39
 Identities = 89/211 (42%), Positives = 124/211 (58%), Gaps = 8/211 (3%)
 Frame = +2

Query: 407  PVVKGRRRRGAISAEVYT----EEDAASYVRKVIPKDYKTMAALAKAIEKNVLFSHLDDN 574
            PV+    RR ++ AE Y     E+DA S  R + PK       L +A +  +LF +LD  
Sbjct: 45   PVINRFTRRASVCAEAYNPDEEEDDAES--RIIHPKTDDQRNRLQEACKDILLFKNLDPE 102

Query: 575  ERSDIFDAMFPVSFIAGETVIQQGDEGDNFYVIDQGEMDVYVN----NEWATSVGEGGSF 742
            + S + DAMF      GE VI QGD+GDNFYVID+G  D+YV          +    GSF
Sbjct: 103  QMSQVLDAMFEKLVKEGEHVIDQGDDGDNFYVIDRGTFDIYVKCDGVGRCVGNYDNRGSF 162

Query: 743  GELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSILESLD 922
            GELAL+Y TPRAAT+ A +   LWG+DR ++RRI++ +  +KRKMYE F+  +  L+SL+
Sbjct: 163  GELALMYNTPRAATITATSPGALWGLDRVTFRRIIVKNNAKKRKMYESFIESLPFLKSLE 222

Query: 923  KWERLTVADALEPVQFEDGQKIVVQGEQGTS 1015
              ERL V D +    + DG++I+ QG+   S
Sbjct: 223  VSERLKVVDVIGTKVYNDGEQIIAQGDLADS 253



 Score = 64.3 bits (155), Expect = 1e-10
 Identities = 44/156 (28%), Positives = 72/156 (46%), Gaps = 14/156 (8%)
 Frame = +2

Query: 467 DAASYVRKVIPKDYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFPVSFIAGETVIQQG 646
           D  ++ R ++  + K        IE       L+ +ER  + D +    +  GE +I QG
Sbjct: 189 DRVTFRRIIVKNNAKKRKMYESFIESLPFLKSLEVSERLKVVDVIGTKVYNDGEQIIAQG 248

Query: 647 DEGDNFYVIDQGEMDVYVNNEWATSVGEGGS-----------FGELALIYGTPRAATVKA 793
           D  D+F++++ GE+ + +  +  + V E G+           FGELAL+   PRAA+  A
Sbjct: 249 DLADSFFIVESGEVKITMKRKGKSEVEENGAVEIARCSRGQYFGELALVTNKPRAASAHA 308

Query: 794 KTNVKLWGIDRDSYRRIL---MGSTLRKRKMYEEFL 892
              VK   +D  ++ R+L   M    R    YEE L
Sbjct: 309 IGTVKCLAMDVQAFERLLGPCMEIMKRNIATYEEQL 344


>ref|NP_001038039.1| cGMP-dependent protein kinase 1 [Sus scrofa].
          Length = 671

 Score =  121 bits (303), Expect = 7e-28
 Identities = 82/262 (31%), Positives = 134/262 (51%), Gaps = 3/262 (1%)
 Frame = +2

Query: 233  LKDSIVQLCTARPERPMAFLREYFERLEKEEAKQIQNLQKASARADSREDEISPPPPNPV 412
            L++   ++   + ER    ++E  +RL ++E ++IQ L++   +  S    + P P   +
Sbjct: 4    LEEDFAKILMLKEER----IKELEKRLSEKE-EEIQELKRKLHKCQS----VLPVPSTHI 54

Query: 413  VKGRRRRGAISAEVYTEE---DAASYVRKVIPKDYKTMAALAKAIEKNVLFSHLDDNERS 583
                 R   ISAE  T     D     RK   K  ++   + +AI  N    +L+ ++  
Sbjct: 55   GPRTTRAQGISAEPQTYRSFHDLRQAFRK-FTKSERSKDLIKEAILDNDFMKNLELSQIQ 113

Query: 584  DIFDAMFPVSFIAGETVIQQGDEGDNFYVIDQGEMDVYVNNEWATSVGEGGSFGELALIY 763
            +I D M+PV +     +I++GD G   YV++ G+++V        ++G G  FGELA++Y
Sbjct: 114  EIVDCMYPVEYGKDSCIIKEGDVGSLVYVMEDGKVEVTKEGVKLCTMGPGKVFGELAILY 173

Query: 764  GTPRAATVKAKTNVKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSILESLDKWERLTV 943
               R ATVK   NVKLW IDR  ++ I+M + L K   Y EFL  V   +SL +     +
Sbjct: 174  NCTRTATVKTLVNVKLWAIDRQCFQTIMMRTGLIKHTEYMEFLKSVPTFQSLPEEILSKL 233

Query: 944  ADALEPVQFEDGQKIVVQGEQG 1009
            AD LE   +E+G+ I+ QG +G
Sbjct: 234  ADVLEETHYENGEYIIRQGARG 255



 Score = 55.1 bits (131), Expect = 7e-08
 Identities = 37/121 (30%), Positives = 60/121 (49%), Gaps = 6/121 (4%)
 Frame = +2

Query: 554 FSHLDDNERSDIFDAMFPVSFIAGETVIQQGDEGDNFYVIDQGEMDVYVNNE------WA 715
           F  L +   S + D +    +  GE +I+QG  GD F++I +G+++V   +       + 
Sbjct: 222 FQSLPEEILSKLADVLEETHYENGEYIIRQGARGDTFFIISKGKVNVTREDSPSEDPIFL 281

Query: 716 TSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTLRKRKMYEEFLS 895
            ++G+G  FGE AL     R A V A   V    IDRDS++ ++ G      K YE+  +
Sbjct: 282 RTLGKGDWFGEKALQGEDVRTANVIAAEAVTCLVIDRDSFKHLIGGLDDVSNKAYEDAEA 341

Query: 896 K 898
           K
Sbjct: 342 K 342


>ref|XP_003129412.2| PREDICTED: cGMP-dependent protein kinase 2 [Sus scrofa].
          Length = 1053

 Score =  110 bits (275), Expect = 1e-24
 Identities = 82/305 (26%), Positives = 140/305 (45%), Gaps = 6/305 (1%)
 Frame = +2

Query: 119  PAAVCPQGTMASGSTAXXXXXXXXXXXXYVQKHNIQALLKDSIVQLCTARPERPMAFLRE 298
            PA   P+G + +GS               V     Q+ + D +   CT R E   A L E
Sbjct: 317  PATWAPRGPLPAGSYFFRASWRLLLLVTKVS----QSCVLDGLRDGCTRRGEG--ALLGE 370

Query: 299  YFERLEKEEAKQIQNLQKASARADSREDEISPPPP------NPVVKGRRRRGAISAEVYT 460
                L  EE    +  ++   RA  R   I  P           + G   RG    E Y 
Sbjct: 371  -MRGLSVEETLLSRVWRRMGGRATERVWRIGDPQAVRWAWATLSMGGWTGRGLDCQESYP 429

Query: 461  EEDAASYVRKVIPKDYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFPVSFIAGETVIQ 640
              +  + V  V          +  A+ KN     LD  +  D+ + M+  +F  G  +I+
Sbjct: 430  HCEGVT-VTVVTEVALNEKKLITDALNKNQFLKRLDPQQIKDMVECMYGRNFQQGSYIIK 488

Query: 641  QGDEGDNFYVIDQGEMDVYVNNEWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGI 820
            QG+ G++ +V+ +G ++V+   +  +S+    +FGELA++Y   R A+VKA TNVK W +
Sbjct: 489  QGEPGNHIFVLAEGRLEVFQGEKLLSSIPMWTTFGELAILYNCTRTASVKAITNVKTWAL 548

Query: 821  DRDSYRRILMGSTLRKRKMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQG 1000
            DR+ ++ I+  +   + + Y  FL  VS+L++L + +   + D LE   ++ G  I+ +G
Sbjct: 549  DREVFQNIMRRTAQARDEQYRNFLRSVSLLKNLPEDKLTKIIDCLEVEYYDKGDYIIREG 608

Query: 1001 EQGTS 1015
            E+G++
Sbjct: 609  EEGST 613


>ref|XP_003133536.2| PREDICTED: rap guanine nucleotide exchange factor 4-like, partial
           [Sus scrofa].
          Length = 832

 Score = 53.1 bits (126), Expect = 2e-07
 Identities = 40/143 (27%), Positives = 74/143 (51%), Gaps = 6/143 (4%)
 Frame = +2

Query: 557 SHLDDNERSDIFDAMFPVSFIAGETVI-QQGDEGDNFYVIDQGEMDVYVNNEWAT-SVGE 730
           SHL    + ++   +   S   G TV+  QG+EG ++Y+I +G ++V +  +    ++ E
Sbjct: 179 SHLSTTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHE 238

Query: 731 GGSFGELALIYGTPRAAT-VKAKTNVKLWGIDRDSYRRILM---GSTLRKRKMYEEFLSK 898
           G  FG+LAL+   PRAA+ V  + N     +D++ + RIL     +T+R ++  ++ L  
Sbjct: 239 GDDFGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQDVL-- 296

Query: 899 VSILESLDKWERLTVADALEPVQ 967
             +LE +    R +     +P Q
Sbjct: 297 --VLEKVPAGNRASNQGNSQPQQ 317


  Database: RefSeq49_SP.fasta
    Posted date:  Oct 17, 2011  1:42 PM
  Number of letters in database: 11,343,932
  Number of sequences in database:  24,897
  
Lambda     K      H
   0.318    0.134    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 24897
Number of Hits to DB: 25,832,172
Number of extensions: 697314
Number of successful extensions: 2702
Number of sequences better than 1.0e-05: 7
Number of HSP's gapped: 2678
Number of HSP's successfully gapped: 13
Length of query: 351
Length of database: 11,343,932
Length adjustment: 100
Effective length of query: 251
Effective length of database: 8,854,232
Effective search space: 2222412232
Effective search space used: 2222412232
Neighboring words threshold: 12
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 34 (17.7 bits)

BLASTX 2.2.24 [Aug-08-2010]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= 20110601C-007684
         (1055 letters)

Database: RefSeq49_HP.fasta 
           32,964 sequences; 18,297,164 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

Alignment   gi|NP_997637.1| cAMP-dependent protein kinase type I-alpha regu...   521   e-148
Alignment   gi|NP_997636.1| cAMP-dependent protein kinase type I-alpha regu...   521   e-148
Alignment   gi|NP_002725.1| cAMP-dependent protein kinase type I-alpha regu...   521   e-148
Alignment   gi|NP_001158234.1| cAMP-dependent protein kinase type I-beta re...   451   e-127
Alignment   gi|NP_001158233.1| cAMP-dependent protein kinase type I-beta re...   451   e-127
Alignment   gi|NP_001158232.1| cAMP-dependent protein kinase type I-beta re...   451   e-127
Alignment   gi|NP_001158231.1| cAMP-dependent protein kinase type I-beta re...   451   e-127
Alignment   gi|NP_001158230.1| cAMP-dependent protein kinase type I-beta re...   451   e-127
Alignment   gi|NP_002726.1| cAMP-dependent protein kinase type I-beta regul...   451   e-127
Alignment   gi|NP_004148.1| cAMP-dependent protein kinase type II-alpha reg...   163   2e-40

>ref|NP_997637.1| cAMP-dependent protein kinase type I-alpha regulatory subunit [Homo
            sapiens].
          Length = 381

 Score =  521 bits (1343), Expect = e-148
 Identities = 269/289 (93%), Positives = 269/289 (93%), Gaps = 1/289 (0%)
 Frame = +2

Query: 146  MASGSTAXXXXXXXXXXXX-YVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKE 322
            M SGSTA             YVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKE
Sbjct: 1    MESGSTAASEEARSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKE 60

Query: 323  EAKQIQNLQKASARADSREDEISPPPPNPVVKGRRRRGAISAEVYTEEDAASYVRKVIPK 502
            EAKQIQNLQKA  R DSREDEISPPPPNPVVKGRRRRGAISAEVYTEEDAASYVRKVIPK
Sbjct: 61   EAKQIQNLQKAGTRTDSREDEISPPPPNPVVKGRRRRGAISAEVYTEEDAASYVRKVIPK 120

Query: 503  DYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFPVSFIAGETVIQQGDEGDNFYVIDQG 682
            DYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMF VSFIAGETVIQQGDEGDNFYVIDQG
Sbjct: 121  DYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFSVSFIAGETVIQQGDEGDNFYVIDQG 180

Query: 683  EMDVYVNNEWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTL 862
            E DVYVNNEWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTL
Sbjct: 181  ETDVYVNNEWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTL 240

Query: 863  RKRKMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEQG 1009
            RKRKMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGE G
Sbjct: 241  RKRKMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEPG 289



 Score = 69.7 bits (169), Expect = 4e-12
 Identities = 51/152 (33%), Positives = 76/152 (50%), Gaps = 9/152 (5%)
 Frame = +2

Query: 467 DAASYVRKVIPKDYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFPVSFIAGETVIQQG 646
           D  SY R ++    +      + + K  +   LD  ER  + DA+ PV F  G+ ++ QG
Sbjct: 227 DRDSYRRILMGSTLRKRKMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQG 286

Query: 647 DEGDNFYVIDQGEMDVY---VNNEWATSVGEGGS---FGELALIYGTPRAATVKAKTNVK 808
           + GD F++I +G   V      NE    VG  G    FGE+AL+   PRAATV A+  +K
Sbjct: 287 EPGDEFFIILEGSAAVLQRRSENEEFVEVGRLGPSDYFGEIALLMNRPRAATVVARGPLK 346

Query: 809 LWGIDRDSYRRIL-MGSTLRKR--KMYEEFLS 895
              +DR  + R+L   S + KR  + Y  F+S
Sbjct: 347 CVKLDRPRFERVLGPCSDILKRNIQQYNSFVS 378


>ref|NP_997636.1| cAMP-dependent protein kinase type I-alpha regulatory subunit [Homo
            sapiens].
          Length = 381

 Score =  521 bits (1343), Expect = e-148
 Identities = 269/289 (93%), Positives = 269/289 (93%), Gaps = 1/289 (0%)
 Frame = +2

Query: 146  MASGSTAXXXXXXXXXXXX-YVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKE 322
            M SGSTA             YVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKE
Sbjct: 1    MESGSTAASEEARSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKE 60

Query: 323  EAKQIQNLQKASARADSREDEISPPPPNPVVKGRRRRGAISAEVYTEEDAASYVRKVIPK 502
            EAKQIQNLQKA  R DSREDEISPPPPNPVVKGRRRRGAISAEVYTEEDAASYVRKVIPK
Sbjct: 61   EAKQIQNLQKAGTRTDSREDEISPPPPNPVVKGRRRRGAISAEVYTEEDAASYVRKVIPK 120

Query: 503  DYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFPVSFIAGETVIQQGDEGDNFYVIDQG 682
            DYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMF VSFIAGETVIQQGDEGDNFYVIDQG
Sbjct: 121  DYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFSVSFIAGETVIQQGDEGDNFYVIDQG 180

Query: 683  EMDVYVNNEWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTL 862
            E DVYVNNEWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTL
Sbjct: 181  ETDVYVNNEWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTL 240

Query: 863  RKRKMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEQG 1009
            RKRKMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGE G
Sbjct: 241  RKRKMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEPG 289



 Score = 69.7 bits (169), Expect = 4e-12
 Identities = 51/152 (33%), Positives = 76/152 (50%), Gaps = 9/152 (5%)
 Frame = +2

Query: 467 DAASYVRKVIPKDYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFPVSFIAGETVIQQG 646
           D  SY R ++    +      + + K  +   LD  ER  + DA+ PV F  G+ ++ QG
Sbjct: 227 DRDSYRRILMGSTLRKRKMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQG 286

Query: 647 DEGDNFYVIDQGEMDVY---VNNEWATSVGEGGS---FGELALIYGTPRAATVKAKTNVK 808
           + GD F++I +G   V      NE    VG  G    FGE+AL+   PRAATV A+  +K
Sbjct: 287 EPGDEFFIILEGSAAVLQRRSENEEFVEVGRLGPSDYFGEIALLMNRPRAATVVARGPLK 346

Query: 809 LWGIDRDSYRRIL-MGSTLRKR--KMYEEFLS 895
              +DR  + R+L   S + KR  + Y  F+S
Sbjct: 347 CVKLDRPRFERVLGPCSDILKRNIQQYNSFVS 378


>ref|NP_002725.1| cAMP-dependent protein kinase type I-alpha regulatory subunit [Homo
            sapiens].
          Length = 381

 Score =  521 bits (1343), Expect = e-148
 Identities = 269/289 (93%), Positives = 269/289 (93%), Gaps = 1/289 (0%)
 Frame = +2

Query: 146  MASGSTAXXXXXXXXXXXX-YVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKE 322
            M SGSTA             YVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKE
Sbjct: 1    MESGSTAASEEARSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKE 60

Query: 323  EAKQIQNLQKASARADSREDEISPPPPNPVVKGRRRRGAISAEVYTEEDAASYVRKVIPK 502
            EAKQIQNLQKA  R DSREDEISPPPPNPVVKGRRRRGAISAEVYTEEDAASYVRKVIPK
Sbjct: 61   EAKQIQNLQKAGTRTDSREDEISPPPPNPVVKGRRRRGAISAEVYTEEDAASYVRKVIPK 120

Query: 503  DYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFPVSFIAGETVIQQGDEGDNFYVIDQG 682
            DYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMF VSFIAGETVIQQGDEGDNFYVIDQG
Sbjct: 121  DYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFSVSFIAGETVIQQGDEGDNFYVIDQG 180

Query: 683  EMDVYVNNEWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTL 862
            E DVYVNNEWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTL
Sbjct: 181  ETDVYVNNEWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTL 240

Query: 863  RKRKMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEQG 1009
            RKRKMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGE G
Sbjct: 241  RKRKMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEPG 289



 Score = 69.7 bits (169), Expect = 4e-12
 Identities = 51/152 (33%), Positives = 76/152 (50%), Gaps = 9/152 (5%)
 Frame = +2

Query: 467 DAASYVRKVIPKDYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFPVSFIAGETVIQQG 646
           D  SY R ++    +      + + K  +   LD  ER  + DA+ PV F  G+ ++ QG
Sbjct: 227 DRDSYRRILMGSTLRKRKMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQG 286

Query: 647 DEGDNFYVIDQGEMDVY---VNNEWATSVGEGGS---FGELALIYGTPRAATVKAKTNVK 808
           + GD F++I +G   V      NE    VG  G    FGE+AL+   PRAATV A+  +K
Sbjct: 287 EPGDEFFIILEGSAAVLQRRSENEEFVEVGRLGPSDYFGEIALLMNRPRAATVVARGPLK 346

Query: 809 LWGIDRDSYRRIL-MGSTLRKR--KMYEEFLS 895
              +DR  + R+L   S + KR  + Y  F+S
Sbjct: 347 CVKLDRPRFERVLGPCSDILKRNIQQYNSFVS 378


>ref|NP_001158234.1| cAMP-dependent protein kinase type I-beta regulatory subunit [Homo
            sapiens].
          Length = 381

 Score =  451 bits (1161), Expect = e-127
 Identities = 220/269 (81%), Positives = 246/269 (91%)
 Frame = +2

Query: 203  YVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKEEAKQIQNLQKASARADSRED 382
            YVQ H IQ +LKD IV LC ++PERPM FLRE+FE+LEKEE +QI   QK+++++DS ++
Sbjct: 21   YVQLHGIQQVLKDCIVHLCISKPERPMKFLREHFEKLEKEENRQILARQKSNSQSDSHDE 80

Query: 383  EISPPPPNPVVKGRRRRGAISAEVYTEEDAASYVRKVIPKDYKTMAALAKAIEKNVLFSH 562
            E+SP PPNPVVK RRRRG +SAEVYTEEDA SYVRKVIPKDYKTM ALAKAI KNVLF+H
Sbjct: 81   EVSPTPPNPVVKARRRRGGVSAEVYTEEDAVSYVRKVIPKDYKTMTALAKAISKNVLFAH 140

Query: 563  LDDNERSDIFDAMFPVSFIAGETVIQQGDEGDNFYVIDQGEMDVYVNNEWATSVGEGGSF 742
            LDDNERSDIFDAMFPV+ IAGETVIQQG+EGDNFYV+DQGE+DVYVN EW T++ EGGSF
Sbjct: 141  LDDNERSDIFDAMFPVTHIAGETVIQQGNEGDNFYVVDQGEVDVYVNGEWVTNISEGGSF 200

Query: 743  GELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSILESLD 922
            GELALIYGTPRAATVKAKT++KLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSILESL+
Sbjct: 201  GELALIYGTPRAATVKAKTDLKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSILESLE 260

Query: 923  KWERLTVADALEPVQFEDGQKIVVQGEQG 1009
            KWERLTVADALEPVQFEDG+KIVVQGE G
Sbjct: 261  KWERLTVADALEPVQFEDGEKIVVQGEPG 289



 Score = 73.2 bits (178), Expect = 4e-13
 Identities = 52/152 (34%), Positives = 77/152 (50%), Gaps = 9/152 (5%)
 Frame = +2

Query: 467 DAASYVRKVIPKDYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFPVSFIAGETVIQQG 646
           D  SY R ++    +      + + K  +   L+  ER  + DA+ PV F  GE ++ QG
Sbjct: 227 DRDSYRRILMGSTLRKRKMYEEFLSKVSILESLEKWERLTVADALEPVQFEDGEKIVVQG 286

Query: 647 DEGDNFYVIDQGEMDVYVN---NEWATSVGEGGS---FGELALIYGTPRAATVKAKTNVK 808
           + GD+FY+I +G   V      NE    VG  G    FGE+AL+   PRAATV A+  +K
Sbjct: 287 EPGDDFYIITEGTASVLQRRSPNEEYVEVGRLGPSDYFGEIALLLNRPRAATVVARGPLK 346

Query: 809 LWGIDRDSYRRIL-MGSTLRKRKM--YEEFLS 895
              +DR  + R+L   S + KR +  Y  F+S
Sbjct: 347 CVKLDRPRFERVLGPCSEILKRNIQRYNSFIS 378


>ref|NP_001158233.1| cAMP-dependent protein kinase type I-beta regulatory subunit [Homo
            sapiens].
          Length = 381

 Score =  451 bits (1161), Expect = e-127
 Identities = 220/269 (81%), Positives = 246/269 (91%)
 Frame = +2

Query: 203  YVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKEEAKQIQNLQKASARADSRED 382
            YVQ H IQ +LKD IV LC ++PERPM FLRE+FE+LEKEE +QI   QK+++++DS ++
Sbjct: 21   YVQLHGIQQVLKDCIVHLCISKPERPMKFLREHFEKLEKEENRQILARQKSNSQSDSHDE 80

Query: 383  EISPPPPNPVVKGRRRRGAISAEVYTEEDAASYVRKVIPKDYKTMAALAKAIEKNVLFSH 562
            E+SP PPNPVVK RRRRG +SAEVYTEEDA SYVRKVIPKDYKTM ALAKAI KNVLF+H
Sbjct: 81   EVSPTPPNPVVKARRRRGGVSAEVYTEEDAVSYVRKVIPKDYKTMTALAKAISKNVLFAH 140

Query: 563  LDDNERSDIFDAMFPVSFIAGETVIQQGDEGDNFYVIDQGEMDVYVNNEWATSVGEGGSF 742
            LDDNERSDIFDAMFPV+ IAGETVIQQG+EGDNFYV+DQGE+DVYVN EW T++ EGGSF
Sbjct: 141  LDDNERSDIFDAMFPVTHIAGETVIQQGNEGDNFYVVDQGEVDVYVNGEWVTNISEGGSF 200

Query: 743  GELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSILESLD 922
            GELALIYGTPRAATVKAKT++KLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSILESL+
Sbjct: 201  GELALIYGTPRAATVKAKTDLKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSILESLE 260

Query: 923  KWERLTVADALEPVQFEDGQKIVVQGEQG 1009
            KWERLTVADALEPVQFEDG+KIVVQGE G
Sbjct: 261  KWERLTVADALEPVQFEDGEKIVVQGEPG 289



 Score = 73.2 bits (178), Expect = 4e-13
 Identities = 52/152 (34%), Positives = 77/152 (50%), Gaps = 9/152 (5%)
 Frame = +2

Query: 467 DAASYVRKVIPKDYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFPVSFIAGETVIQQG 646
           D  SY R ++    +      + + K  +   L+  ER  + DA+ PV F  GE ++ QG
Sbjct: 227 DRDSYRRILMGSTLRKRKMYEEFLSKVSILESLEKWERLTVADALEPVQFEDGEKIVVQG 286

Query: 647 DEGDNFYVIDQGEMDVYVN---NEWATSVGEGGS---FGELALIYGTPRAATVKAKTNVK 808
           + GD+FY+I +G   V      NE    VG  G    FGE+AL+   PRAATV A+  +K
Sbjct: 287 EPGDDFYIITEGTASVLQRRSPNEEYVEVGRLGPSDYFGEIALLLNRPRAATVVARGPLK 346

Query: 809 LWGIDRDSYRRIL-MGSTLRKRKM--YEEFLS 895
              +DR  + R+L   S + KR +  Y  F+S
Sbjct: 347 CVKLDRPRFERVLGPCSEILKRNIQRYNSFIS 378


>ref|NP_001158232.1| cAMP-dependent protein kinase type I-beta regulatory subunit [Homo
            sapiens].
          Length = 381

 Score =  451 bits (1161), Expect = e-127
 Identities = 220/269 (81%), Positives = 246/269 (91%)
 Frame = +2

Query: 203  YVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKEEAKQIQNLQKASARADSRED 382
            YVQ H IQ +LKD IV LC ++PERPM FLRE+FE+LEKEE +QI   QK+++++DS ++
Sbjct: 21   YVQLHGIQQVLKDCIVHLCISKPERPMKFLREHFEKLEKEENRQILARQKSNSQSDSHDE 80

Query: 383  EISPPPPNPVVKGRRRRGAISAEVYTEEDAASYVRKVIPKDYKTMAALAKAIEKNVLFSH 562
            E+SP PPNPVVK RRRRG +SAEVYTEEDA SYVRKVIPKDYKTM ALAKAI KNVLF+H
Sbjct: 81   EVSPTPPNPVVKARRRRGGVSAEVYTEEDAVSYVRKVIPKDYKTMTALAKAISKNVLFAH 140

Query: 563  LDDNERSDIFDAMFPVSFIAGETVIQQGDEGDNFYVIDQGEMDVYVNNEWATSVGEGGSF 742
            LDDNERSDIFDAMFPV+ IAGETVIQQG+EGDNFYV+DQGE+DVYVN EW T++ EGGSF
Sbjct: 141  LDDNERSDIFDAMFPVTHIAGETVIQQGNEGDNFYVVDQGEVDVYVNGEWVTNISEGGSF 200

Query: 743  GELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSILESLD 922
            GELALIYGTPRAATVKAKT++KLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSILESL+
Sbjct: 201  GELALIYGTPRAATVKAKTDLKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSILESLE 260

Query: 923  KWERLTVADALEPVQFEDGQKIVVQGEQG 1009
            KWERLTVADALEPVQFEDG+KIVVQGE G
Sbjct: 261  KWERLTVADALEPVQFEDGEKIVVQGEPG 289



 Score = 73.2 bits (178), Expect = 4e-13
 Identities = 52/152 (34%), Positives = 77/152 (50%), Gaps = 9/152 (5%)
 Frame = +2

Query: 467 DAASYVRKVIPKDYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFPVSFIAGETVIQQG 646
           D  SY R ++    +      + + K  +   L+  ER  + DA+ PV F  GE ++ QG
Sbjct: 227 DRDSYRRILMGSTLRKRKMYEEFLSKVSILESLEKWERLTVADALEPVQFEDGEKIVVQG 286

Query: 647 DEGDNFYVIDQGEMDVYVN---NEWATSVGEGGS---FGELALIYGTPRAATVKAKTNVK 808
           + GD+FY+I +G   V      NE    VG  G    FGE+AL+   PRAATV A+  +K
Sbjct: 287 EPGDDFYIITEGTASVLQRRSPNEEYVEVGRLGPSDYFGEIALLLNRPRAATVVARGPLK 346

Query: 809 LWGIDRDSYRRIL-MGSTLRKRKM--YEEFLS 895
              +DR  + R+L   S + KR +  Y  F+S
Sbjct: 347 CVKLDRPRFERVLGPCSEILKRNIQRYNSFIS 378


>ref|NP_001158231.1| cAMP-dependent protein kinase type I-beta regulatory subunit [Homo
            sapiens].
          Length = 381

 Score =  451 bits (1161), Expect = e-127
 Identities = 220/269 (81%), Positives = 246/269 (91%)
 Frame = +2

Query: 203  YVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKEEAKQIQNLQKASARADSRED 382
            YVQ H IQ +LKD IV LC ++PERPM FLRE+FE+LEKEE +QI   QK+++++DS ++
Sbjct: 21   YVQLHGIQQVLKDCIVHLCISKPERPMKFLREHFEKLEKEENRQILARQKSNSQSDSHDE 80

Query: 383  EISPPPPNPVVKGRRRRGAISAEVYTEEDAASYVRKVIPKDYKTMAALAKAIEKNVLFSH 562
            E+SP PPNPVVK RRRRG +SAEVYTEEDA SYVRKVIPKDYKTM ALAKAI KNVLF+H
Sbjct: 81   EVSPTPPNPVVKARRRRGGVSAEVYTEEDAVSYVRKVIPKDYKTMTALAKAISKNVLFAH 140

Query: 563  LDDNERSDIFDAMFPVSFIAGETVIQQGDEGDNFYVIDQGEMDVYVNNEWATSVGEGGSF 742
            LDDNERSDIFDAMFPV+ IAGETVIQQG+EGDNFYV+DQGE+DVYVN EW T++ EGGSF
Sbjct: 141  LDDNERSDIFDAMFPVTHIAGETVIQQGNEGDNFYVVDQGEVDVYVNGEWVTNISEGGSF 200

Query: 743  GELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSILESLD 922
            GELALIYGTPRAATVKAKT++KLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSILESL+
Sbjct: 201  GELALIYGTPRAATVKAKTDLKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSILESLE 260

Query: 923  KWERLTVADALEPVQFEDGQKIVVQGEQG 1009
            KWERLTVADALEPVQFEDG+KIVVQGE G
Sbjct: 261  KWERLTVADALEPVQFEDGEKIVVQGEPG 289



 Score = 73.2 bits (178), Expect = 4e-13
 Identities = 52/152 (34%), Positives = 77/152 (50%), Gaps = 9/152 (5%)
 Frame = +2

Query: 467 DAASYVRKVIPKDYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFPVSFIAGETVIQQG 646
           D  SY R ++    +      + + K  +   L+  ER  + DA+ PV F  GE ++ QG
Sbjct: 227 DRDSYRRILMGSTLRKRKMYEEFLSKVSILESLEKWERLTVADALEPVQFEDGEKIVVQG 286

Query: 647 DEGDNFYVIDQGEMDVYVN---NEWATSVGEGGS---FGELALIYGTPRAATVKAKTNVK 808
           + GD+FY+I +G   V      NE    VG  G    FGE+AL+   PRAATV A+  +K
Sbjct: 287 EPGDDFYIITEGTASVLQRRSPNEEYVEVGRLGPSDYFGEIALLLNRPRAATVVARGPLK 346

Query: 809 LWGIDRDSYRRIL-MGSTLRKRKM--YEEFLS 895
              +DR  + R+L   S + KR +  Y  F+S
Sbjct: 347 CVKLDRPRFERVLGPCSEILKRNIQRYNSFIS 378


>ref|NP_001158230.1| cAMP-dependent protein kinase type I-beta regulatory subunit [Homo
            sapiens].
          Length = 381

 Score =  451 bits (1161), Expect = e-127
 Identities = 220/269 (81%), Positives = 246/269 (91%)
 Frame = +2

Query: 203  YVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKEEAKQIQNLQKASARADSRED 382
            YVQ H IQ +LKD IV LC ++PERPM FLRE+FE+LEKEE +QI   QK+++++DS ++
Sbjct: 21   YVQLHGIQQVLKDCIVHLCISKPERPMKFLREHFEKLEKEENRQILARQKSNSQSDSHDE 80

Query: 383  EISPPPPNPVVKGRRRRGAISAEVYTEEDAASYVRKVIPKDYKTMAALAKAIEKNVLFSH 562
            E+SP PPNPVVK RRRRG +SAEVYTEEDA SYVRKVIPKDYKTM ALAKAI KNVLF+H
Sbjct: 81   EVSPTPPNPVVKARRRRGGVSAEVYTEEDAVSYVRKVIPKDYKTMTALAKAISKNVLFAH 140

Query: 563  LDDNERSDIFDAMFPVSFIAGETVIQQGDEGDNFYVIDQGEMDVYVNNEWATSVGEGGSF 742
            LDDNERSDIFDAMFPV+ IAGETVIQQG+EGDNFYV+DQGE+DVYVN EW T++ EGGSF
Sbjct: 141  LDDNERSDIFDAMFPVTHIAGETVIQQGNEGDNFYVVDQGEVDVYVNGEWVTNISEGGSF 200

Query: 743  GELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSILESLD 922
            GELALIYGTPRAATVKAKT++KLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSILESL+
Sbjct: 201  GELALIYGTPRAATVKAKTDLKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSILESLE 260

Query: 923  KWERLTVADALEPVQFEDGQKIVVQGEQG 1009
            KWERLTVADALEPVQFEDG+KIVVQGE G
Sbjct: 261  KWERLTVADALEPVQFEDGEKIVVQGEPG 289



 Score = 73.2 bits (178), Expect = 4e-13
 Identities = 52/152 (34%), Positives = 77/152 (50%), Gaps = 9/152 (5%)
 Frame = +2

Query: 467 DAASYVRKVIPKDYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFPVSFIAGETVIQQG 646
           D  SY R ++    +      + + K  +   L+  ER  + DA+ PV F  GE ++ QG
Sbjct: 227 DRDSYRRILMGSTLRKRKMYEEFLSKVSILESLEKWERLTVADALEPVQFEDGEKIVVQG 286

Query: 647 DEGDNFYVIDQGEMDVYVN---NEWATSVGEGGS---FGELALIYGTPRAATVKAKTNVK 808
           + GD+FY+I +G   V      NE    VG  G    FGE+AL+   PRAATV A+  +K
Sbjct: 287 EPGDDFYIITEGTASVLQRRSPNEEYVEVGRLGPSDYFGEIALLLNRPRAATVVARGPLK 346

Query: 809 LWGIDRDSYRRIL-MGSTLRKRKM--YEEFLS 895
              +DR  + R+L   S + KR +  Y  F+S
Sbjct: 347 CVKLDRPRFERVLGPCSEILKRNIQRYNSFIS 378


>ref|NP_002726.1| cAMP-dependent protein kinase type I-beta regulatory subunit [Homo
            sapiens].
          Length = 381

 Score =  451 bits (1161), Expect = e-127
 Identities = 220/269 (81%), Positives = 246/269 (91%)
 Frame = +2

Query: 203  YVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKEEAKQIQNLQKASARADSRED 382
            YVQ H IQ +LKD IV LC ++PERPM FLRE+FE+LEKEE +QI   QK+++++DS ++
Sbjct: 21   YVQLHGIQQVLKDCIVHLCISKPERPMKFLREHFEKLEKEENRQILARQKSNSQSDSHDE 80

Query: 383  EISPPPPNPVVKGRRRRGAISAEVYTEEDAASYVRKVIPKDYKTMAALAKAIEKNVLFSH 562
            E+SP PPNPVVK RRRRG +SAEVYTEEDA SYVRKVIPKDYKTM ALAKAI KNVLF+H
Sbjct: 81   EVSPTPPNPVVKARRRRGGVSAEVYTEEDAVSYVRKVIPKDYKTMTALAKAISKNVLFAH 140

Query: 563  LDDNERSDIFDAMFPVSFIAGETVIQQGDEGDNFYVIDQGEMDVYVNNEWATSVGEGGSF 742
            LDDNERSDIFDAMFPV+ IAGETVIQQG+EGDNFYV+DQGE+DVYVN EW T++ EGGSF
Sbjct: 141  LDDNERSDIFDAMFPVTHIAGETVIQQGNEGDNFYVVDQGEVDVYVNGEWVTNISEGGSF 200

Query: 743  GELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSILESLD 922
            GELALIYGTPRAATVKAKT++KLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSILESL+
Sbjct: 201  GELALIYGTPRAATVKAKTDLKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSILESLE 260

Query: 923  KWERLTVADALEPVQFEDGQKIVVQGEQG 1009
            KWERLTVADALEPVQFEDG+KIVVQGE G
Sbjct: 261  KWERLTVADALEPVQFEDGEKIVVQGEPG 289



 Score = 73.2 bits (178), Expect = 4e-13
 Identities = 52/152 (34%), Positives = 77/152 (50%), Gaps = 9/152 (5%)
 Frame = +2

Query: 467 DAASYVRKVIPKDYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFPVSFIAGETVIQQG 646
           D  SY R ++    +      + + K  +   L+  ER  + DA+ PV F  GE ++ QG
Sbjct: 227 DRDSYRRILMGSTLRKRKMYEEFLSKVSILESLEKWERLTVADALEPVQFEDGEKIVVQG 286

Query: 647 DEGDNFYVIDQGEMDVYVN---NEWATSVGEGGS---FGELALIYGTPRAATVKAKTNVK 808
           + GD+FY+I +G   V      NE    VG  G    FGE+AL+   PRAATV A+  +K
Sbjct: 287 EPGDDFYIITEGTASVLQRRSPNEEYVEVGRLGPSDYFGEIALLLNRPRAATVVARGPLK 346

Query: 809 LWGIDRDSYRRIL-MGSTLRKRKM--YEEFLS 895
              +DR  + R+L   S + KR +  Y  F+S
Sbjct: 347 CVKLDRPRFERVLGPCSEILKRNIQRYNSFIS 378


>ref|NP_004148.1| cAMP-dependent protein kinase type II-alpha regulatory subunit [Homo
            sapiens].
          Length = 404

 Score =  163 bits (413), Expect = 2e-40
 Identities = 106/286 (37%), Positives = 158/286 (55%), Gaps = 24/286 (8%)
 Frame = +2

Query: 230  LLKDSIVQLCTARPERPMAFLREYFERLEKEEAKQI--------QNL----------QKA 355
            LL+   V++   +P   + F  EYF RL +  A           Q+L          + A
Sbjct: 13   LLQGYTVEVLRQQPPDLVEFAVEYFTRLREARAPASVLPAATPRQSLGHPPPEPGPDRVA 72

Query: 356  SARADSREDEISPPPPNPVVKGRRRRGAISAEVYT--EEDAASYVRKVIPKDYKTMAALA 529
             A+ DS  +E       PV     RR ++ AE Y   EE+  +  R + PK  +    L 
Sbjct: 73   DAKGDSESEE-DEDLEVPVPSRFNRRVSVCAETYNPDEEEEDTDPRVIHPKTDEQRCRLQ 131

Query: 530  KAIEKNVLFSHLDDNERSDIFDAMFPVSFIAGETVIQQGDEGDNFYVIDQGEMDVYVNNE 709
            +A +  +LF +LD  + S + DAMF     A E VI QGD+GDNFYVI++G  D+ V  +
Sbjct: 132  EACKDILLFKNLDQEQLSQVLDAMFERIVKADEHVIDQGDDGDNFYVIERGTYDILVTKD 191

Query: 710  WAT-SVGE---GGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTLRKRKM 877
              T SVG+    GSFGELAL+Y TPRAAT+ A +   LWG+DR ++RRI++ +  +KRKM
Sbjct: 192  NQTRSVGQYDNRGSFGELALMYNTPRAATIVATSEGSLWGLDRVTFRRIIVKNNAKKRKM 251

Query: 878  YEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEQGTS 1015
            +E F+  V +L+SL+  ER+ + D +    ++DG++I+ QGE+  S
Sbjct: 252  FESFIESVPLLKSLEVSERMKIVDVIGEKIYKDGERIITQGEKADS 297



 Score = 66.6 bits (161), Expect = 4e-11
 Identities = 48/161 (29%), Positives = 77/161 (47%), Gaps = 16/161 (9%)
 Frame = +2

Query: 467 DAASYVRKVIPKDYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFPVSFIAGETVIQQG 646
           D  ++ R ++  + K        IE   L   L+ +ER  I D +    +  GE +I QG
Sbjct: 233 DRVTFRRIIVKNNAKKRKMFESFIESVPLLKSLEVSERMKIVDVIGEKIYKDGERIITQG 292

Query: 647 DEGDNFYVIDQGEMDVYVNNEWATSVGEGGS-------------FGELALIYGTPRAATV 787
           ++ D+FY+I+ GE+ + + +    S  +GG+             FGELAL+   PRAA+ 
Sbjct: 293 EKADSFYIIESGEVSILIRSR-TKSNKDGGNQEVEIARCHKGQYFGELALVTNKPRAASA 351

Query: 788 KAKTNVKLWGIDRDSYRRIL---MGSTLRKRKMYEEFLSKV 901
            A  +VK   +D  ++ R+L   M    R    YEE L K+
Sbjct: 352 YAVGDVKCLVMDVQAFERLLGPCMDIMKRNISHYEEQLVKM 392


  Database: RefSeq49_HP.fasta
    Posted date:  Oct 17, 2011  1:42 PM
  Number of letters in database: 18,297,164
  Number of sequences in database:  32,964
  
Lambda     K      H
   0.318    0.134    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 32964
Number of Hits to DB: 41,163,952
Number of extensions: 1102909
Number of successful extensions: 4355
Number of sequences better than 1.0e-05: 19
Number of HSP's gapped: 4305
Number of HSP's successfully gapped: 32
Length of query: 351
Length of database: 18,297,164
Length adjustment: 103
Effective length of query: 248
Effective length of database: 14,901,872
Effective search space: 3695664256
Effective search space used: 3695664256
Neighboring words threshold: 12
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 35 (18.1 bits)

BLASTN 2.2.24 [Aug-08-2010]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= 20110601C-007684
         (1055 letters)

Database: Sscrofa_10.2.fasta 
           4582 sequences; 2,808,509,378 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

Sscrofa_Chr12                                                         363   1e-97
Sscrofa_Chr03                                                          62   7e-07

>Sscrofa_Chr12 
||          Length = 63588571

 Score =  363 bits (183), Expect = 1e-97
 Identities = 183/183 (100%)
 Strand = Plus / Minus

                                                                            
Query: 138      agggaaccatggcgtctggcagcaccgccagtgaggaggagcgtagcctccgggaatgtg 197
                ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 12144119 agggaaccatggcgtctggcagcaccgccagtgaggaggagcgtagcctccgggaatgtg 12144060

                                                                            
Query: 198      agctctacgtccagaagcacaacattcaggccctgctcaaggattctatcgtgcagttgt 257
                ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 12144059 agctctacgtccagaagcacaacattcaggccctgctcaaggattctatcgtgcagttgt 12144000

                                                                            
Query: 258      gcactgcgcggcccgagagacccatggcattcctcagggaatacttcgagaggttggaga 317
                ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 12143999 gcactgcgcggcccgagagacccatggcattcctcagggaatacttcgagaggttggaga 12143940

                   
Query: 318      agg 320
                |||
Sbjct: 12143939 agg 12143937



 Score =  347 bits (175), Expect = 8e-93
 Identities = 175/175 (100%)
 Strand = Plus / Minus

                                                                            
Query: 318      aggaggaggcaaagcagatccagaatctgcagaaagcaagtgcccgggcagactcgaggg 377
                ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 12138900 aggaggaggcaaagcagatccagaatctgcagaaagcaagtgcccgggcagactcgaggg 12138841

                                                                            
Query: 378      aggatgaaatctctcctcctccacccaacccagtggtaaagggccgaaggcgacgaggtg 437
                ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 12138840 aggatgaaatctctcctcctccacccaacccagtggtaaagggccgaaggcgacgaggtg 12138781

                                                                       
Query: 438      ctatcagtgctgaggtctatacggaggaagatgctgcatcatatgttagaaaggt 492
                |||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 12138780 ctatcagtgctgaggtctatacggaggaagatgctgcatcatatgttagaaaggt 12138726



 Score =  317 bits (160), Expect = 7e-84
 Identities = 160/160 (100%)
 Strand = Plus / Minus

                                                                            
Query: 692      gtctacgtcaacaatgagtgggcaaccagtgttggggaaggaggaagctttggagaactt 751
                ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 12135821 gtctacgtcaacaatgagtgggcaaccagtgttggggaaggaggaagctttggagaactt 12135762

                                                                            
Query: 752      gctctgatttatggtacacctagagcagccactgtcaaggcaaagacaaatgtgaaattg 811
                ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 12135761 gctctgatttatggtacacctagagcagccactgtcaaggcaaagacaaatgtgaaattg 12135702

                                                        
Query: 812      tggggtattgaccgagacagctacagaagaatccttatgg 851
                ||||||||||||||||||||||||||||||||||||||||
Sbjct: 12135701 tggggtattgaccgagacagctacagaagaatccttatgg 12135662



 Score =  278 bits (140), Expect = 6e-72
 Identities = 140/140 (100%)
 Strand = Plus / Minus

                                                                            
Query: 1        tgtggctagccgtttccggtggagtcgccgcggagccgctatcgctgtgtgcagccgggc 60
                ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 12147137 tgtggctagccgtttccggtggagtcgccgcggagccgctatcgctgtgtgcagccgggc 12147078

                                                                            
Query: 61       tgggagggaaacgctgagggagctcagcaagccgtcacctcacaccggtaatcccgtgcc 120
                ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 12147077 tgggagggaaacgctgagggagctcagcaagccgtcacctcacaccggtaatcccgtgcc 12147018

                                    
Query: 121      cgccgccgtctgtccccagg 140
                ||||||||||||||||||||
Sbjct: 12147017 cgccgccgtctgtccccagg 12146998



 Score =  228 bits (115), Expect = 5e-57
 Identities = 122/123 (99%), Gaps = 1/123 (0%)
 Strand = Plus / Minus

                                                                            
Query: 906      ttttagaatctctggacaagtgggaacgtcttactgttgctgatgcgttggaaccagtcc 965
                ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 12132683 ttttagaatctctggacaagtgggaacgtcttactgttgctgatgcgttggaaccagtcc 12132624

                                                                            
Query: 966      agtttgaagatggacagaagattgtggtgcagggagaa-caggggacgagttcttcatta 1024
                |||||||||||||||||||||||||||||||||||||| |||||||||||||||||||||
Sbjct: 12132623 agtttgaagatggacagaagattgtggtgcagggagaaccaggggacgagttcttcatta 12132564

                   
Query: 1025     ttt 1027
                |||
Sbjct: 12132563 ttt 12132561



 Score =  186 bits (94), Expect = 2e-44
 Identities = 94/94 (100%)
 Strand = Plus / Minus

                                                                            
Query: 489      aggttataccaaaagattataagacaatggctgctttagctaaagccattgaaaagaatg 548
                ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 12137944 aggttataccaaaagattataagacaatggctgctttagctaaagccattgaaaagaatg 12137885

                                                  
Query: 549      tactgttttcacatcttgatgataatgagagaag 582
                ||||||||||||||||||||||||||||||||||
Sbjct: 12137884 tactgttttcacatcttgatgataatgagagaag 12137851



 Score =  131 bits (66), Expect = 8e-28
 Identities = 66/66 (100%)
 Strand = Plus / Minus

                                                                            
Query: 581      agtgatatttttgatgccatgtttccggtttcctttattgctggagagactgttattcag 640
                ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 12137411 agtgatatttttgatgccatgtttccggtttcctttattgctggagagactgttattcag 12137352

                      
Query: 641      caaggt 646
                ||||||
Sbjct: 12137351 caaggt 12137346



 Score =  123 bits (62), Expect = 2e-25
 Identities = 62/62 (100%)
 Strand = Plus / Minus

                                                                            
Query: 850      gggaagcacgctgagaaagcggaagatgtatgaggagtttcttagtaaagtgtctatttt 909
                ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 12133853 gggaagcacgctgagaaagcggaagatgtatgaggagtttcttagtaaagtgtctatttt 12133794

                  
Query: 910      ag 911
                ||
Sbjct: 12133793 ag 12133792



 Score =  101 bits (51), Expect = 8e-19
 Identities = 51/51 (100%)
 Strand = Plus / Minus

                                                                   
Query: 643      aggtgatgaaggggataacttctatgtgattgatcaaggagagatggatgt 693
                |||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 12136525 aggtgatgaaggggataacttctatgtgattgatcaaggagagatggatgt 12136475


>Sscrofa_Chr03 
||          Length = 144787322

 Score = 61.9 bits (31), Expect = 7e-07
 Identities = 70/83 (84%)
 Strand = Plus / Minus

                                                                          
Query: 917    ctggacaagtgggaacgtcttactgttgctgatgcgttggaaccagtccagtttgaagat 976
              ||||| |||||||| ||||| || || || |||||  |||| || ||||||||||| |||
Sbjct: 205023 ctggagaagtgggagcgtctgacggtggccgatgccctggagcccgtccagtttgaggat 204964

                                     
Query: 977    ggacagaagattgtggtgcaggg 999
              ||| ||||||||||||| |||||
Sbjct: 204963 ggagagaagattgtggtccaggg 204941


  Database: Sscrofa_10.2.fasta
    Posted date:  Nov 16, 2011 10:34 AM
  Number of letters in database: 2,808,509,378
  Number of sequences in database:  4582
  
Lambda     K      H
    1.37    0.711     1.31 

Gapped
Lambda     K      H
    1.37    0.711     1.31 


Matrix: blastn matrix:1 -3
Gap Penalties: Existence: 5, Extension: 2
Number of Sequences: 4582
Number of Hits to DB: 29,551,260
Number of extensions: 194
Number of successful extensions: 194
Number of sequences better than 1.0e-05: 2
Number of HSP's gapped: 193
Number of HSP's successfully gapped: 10
Length of query: 1055
Length of database: 2,808,509,378
Length adjustment: 21
Effective length of query: 1034
Effective length of database: 2,808,413,156
Effective search space: 2903899203304
Effective search space used: 2903899203304
X1: 11 (21.8 bits)
X2: 15 (29.7 bits)
X3: 50 (99.1 bits)
S1: 18 (36.2 bits)
S2: 30 (60.0 bits)