Search to RefSeqBP_Rel49
BLASTX 2.2.24 [Aug-08-2010]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= 20110601C-008065
(1804 letters)
Database: RefSeq49_BP.fasta
33,088 sequences; 17,681,374 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
Alignment gi|NP_001039371.1| [3-methyl-2-oxobutanoate dehydrogenase [lipo... 580 e-165
Alignment gi|NP_001192886.1| [Pyruvate dehydrogenase [lipoamide]] kinase ... 95 9e-28
Alignment gi|XP_002685369.1| PREDICTED: pyruvate dehydrogenase kinase, is... 95 9e-28
Alignment gi|NP_001152953.1| [Pyruvate dehydrogenase [lipoamide]] kinase ... 99 1e-20
Alignment gi|NP_001095404.1| [Pyruvate dehydrogenase [lipoamide]] kinase ... 91 4e-18
Alignment gi|NP_001095353.1| [Pyruvate dehydrogenase [lipoamide]] kinase ... 85 2e-16
Alignment gi|NP_001069321.1| [Pyruvate dehydrogenase [lipoamide]] kinase ... 82 1e-15
>ref|NP_001039371.1| [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase,
mitochondrial precursor [Bos taurus].
Length = 412
Score = 580 bits (1495), Expect = e-165
Identities = 314/412 (76%), Positives = 324/412 (78%)
Frame = +3
Query: 363 TSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYSGRSQDGSHLLKSA 542
TSATDTHHVEMARERSKTVTSFYNQSAID AAEKPSVRLTPTMMLYSGRSQDGSHLLKSA
Sbjct: 32 TSATDTHHVEMARERSKTVTSFYNQSAIDVAAEKPSVRLTPTMMLYSGRSQDGSHLLKSA 91
Query: 543 RYLQQELPVRIAHRIKDFRSLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQY 722
RYLQQELPVRIAHRIK FRSLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEA+Y
Sbjct: 92 RYLQQELPVRIAHRIKGFRSLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEARY 151
Query: 723 CQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRSFLDKTLTSRLGIRMLATHHLALH 902
CQLVRQLLDDHKDVVTLLAEGLRESRK+IEDEKLVR FLDKTLTSRLGIRMLATHHLALH
Sbjct: 152 CQLVRQLLDDHKDVVTLLAEGLRESRKYIEDEKLVRYFLDKTLTSRLGIRMLATHHLALH 211
Query: 903 EDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDY 1082
EDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDY
Sbjct: 212 EDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDY 271
Query: 1083 ILPELLKNAMRATMECHLDTPYNVPDVVITIANNGY*SRHQDF*PGWGNCSQRPGSGYGL 1262
ILPELLKNAMRATME HLDTPYNVPDVVITIANN + S R G
Sbjct: 272 ILPELLKNAMRATMESHLDTPYNVPDVVITIANNDIDLVIR--------ISDRGGGIAHK 323
Query: 1263 PLHHGRGQYPGPPDQPSLRPPRHAQWQPVRTHARVRPHLAGMEGWEAPGDSSL*GPCPVP 1442
L Y + S + PR + P+ H + H G G
Sbjct: 324 DLDRVM-DYHFTTAEASTQDPRIS---PLFGHLDL--HSGGQSG---------------- 361
Query: 1443 LPIPSFGFGLPTSRAYAEYXXXXXXXXXXXXXXTDVYLQLRHIDGREESFRI 1598
P+ FGFGLPTSRAYAEY TDVYL+LRHIDGREESFRI
Sbjct: 362 -PMHGFGFGLPTSRAYAEYLGGSLRLQSLQGIGTDVYLRLRHIDGREESFRI 412
>ref|NP_001192886.1| [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial
[Bos taurus].
Length = 438
Score = 95.1 bits (235), Expect(3) = 9e-28
Identities = 73/224 (32%), Positives = 117/224 (52%), Gaps = 23/224 (10%)
Frame = +3
Query: 537 SARYLQQELPVRIAHRIKDFRSLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADE- 713
S +L+QELPVR+A+ +K+ LP + P++ V YI++ Q+L +F KD++ E
Sbjct: 77 SFMFLRQELPVRLANIMKEISLLPDNLLRTPSVQLVQSWYIQSLQELLEF---KDKSAED 133
Query: 714 ----AQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKL----VRSFLDKTLTSRLGI 869
+ V ++ + H DV+ +AEG+ E ++ + + V+ FLD+ SR+ I
Sbjct: 134 AKTIYDFTDTVIRIRNRHNDVIPTMAEGVVEYKESFGVDPVTSQNVQYFLDRFYMSRISI 193
Query: 870 RMLATHHLALHEDK-------PDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVR 1028
RML H L K VG I S ++I+ + ARRLC+ Y N+P +
Sbjct: 194 RMLLNQHSLLFGGKGKGSLSHRKHVGSINPNCSVVEVIKDGYENARRLCDLYYINSPELE 253
Query: 1029 INGHVAARFP-------FIPMPLDYILPELLKNAMRATMECHLD 1139
+ + A+ P ++P L +++ EL KNAMRATME H D
Sbjct: 254 LE-ELNAKSPGQPIQVVYVPSHLYHMVFELFKNAMRATMEHHAD 296
Score = 37.4 bits (85), Expect(3) = 9e-28
Identities = 17/44 (38%), Positives = 28/44 (63%), Gaps = 1/44 (2%)
Frame = +1
Query: 1192 DLVIRISDRGGGIAHKDLDRVMDYHFTTA-EASTQDPRISPLFG 1320
DL +++SDRGGG+ + +DR+ +Y ++TA + R PL G
Sbjct: 313 DLTVKMSDRGGGVPLRKIDRLFNYMYSTAPRPRVETSRAVPLAG 356
Score = 31.2 bits (69), Expect(3) = 9e-28
Identities = 13/41 (31%), Positives = 20/41 (48%)
Frame = +3
Query: 1443 LPIPSFGFGLPTSRAYAEYXXXXXXXXXXXXXXTDVYLQLR 1565
+P+ FG+GLP SR YA+Y TD + ++
Sbjct: 352 VPLAGFGYGLPISRLYAQYFQGDLKLYSLEGYGTDAVIYIK 392
>ref|XP_002685369.1| PREDICTED: pyruvate dehydrogenase kinase, isozyme 1 [Bos taurus].
Length = 438
Score = 95.1 bits (235), Expect(3) = 9e-28
Identities = 73/224 (32%), Positives = 117/224 (52%), Gaps = 23/224 (10%)
Frame = +3
Query: 537 SARYLQQELPVRIAHRIKDFRSLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADE- 713
S +L+QELPVR+A+ +K+ LP + P++ V YI++ Q+L +F KD++ E
Sbjct: 77 SFMFLRQELPVRLANIMKEISLLPDNLLRTPSVQLVQSWYIQSLQELLEF---KDKSAED 133
Query: 714 ----AQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKL----VRSFLDKTLTSRLGI 869
+ V ++ + H DV+ +AEG+ E ++ + + V+ FLD+ SR+ I
Sbjct: 134 AKTIYDFTDTVIRIRNRHNDVIPTMAEGVVEYKESFGVDPVTSQNVQYFLDRFYMSRISI 193
Query: 870 RMLATHHLALHEDK-------PDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVR 1028
RML H L K VG I S ++I+ + ARRLC+ Y N+P +
Sbjct: 194 RMLLNQHSLLFGGKGKGSLSHRKHVGSINPNCSVVEVIKDGYENARRLCDLYYINSPELE 253
Query: 1029 INGHVAARFP-------FIPMPLDYILPELLKNAMRATMECHLD 1139
+ + A+ P ++P L +++ EL KNAMRATME H D
Sbjct: 254 LE-ELNAKSPGQPIQVVYVPSHLYHMVFELFKNAMRATMEHHAD 296
Score = 37.4 bits (85), Expect(3) = 9e-28
Identities = 17/44 (38%), Positives = 28/44 (63%), Gaps = 1/44 (2%)
Frame = +1
Query: 1192 DLVIRISDRGGGIAHKDLDRVMDYHFTTA-EASTQDPRISPLFG 1320
DL +++SDRGGG+ + +DR+ +Y ++TA + R PL G
Sbjct: 313 DLTVKMSDRGGGVPLRKIDRLFNYMYSTAPRPRVETSRAVPLAG 356
Score = 31.2 bits (69), Expect(3) = 9e-28
Identities = 13/41 (31%), Positives = 20/41 (48%)
Frame = +3
Query: 1443 LPIPSFGFGLPTSRAYAEYXXXXXXXXXXXXXXTDVYLQLR 1565
+P+ FG+GLP SR YA+Y TD + ++
Sbjct: 352 VPLAGFGYGLPISRLYAQYFQGDLKLYSLEGYGTDAVIYIK 392
>ref|NP_001152953.1| [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial
isoform 1 [Bos taurus].
Length = 407
Score = 99.0 bits (245), Expect = 1e-20
Identities = 87/361 (24%), Positives = 150/361 (41%), Gaps = 18/361 (4%)
Frame = +3
Query: 537 SARYLQQELPVRIAHRIKDFRSLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADE- 713
S +L+QELPVR+A+ +K+ LP + P++ V Y+++ + +F KD D
Sbjct: 49 SFTFLRQELPVRLANIMKEINLLPDRVLSTPSVQLVQSWYVQSLLDIMEFLD-KDPEDHR 107
Query: 714 --AQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKL----VRSFLDKTLTSRLGIRM 875
+Q+ + + + H DVV +A+G+ E + D+ + ++ FLD+ SR+ IRM
Sbjct: 108 TLSQFTDALVTIRNRHNDVVPTMAQGVLEYKDTYGDDPVSNQNIQYFLDRFYLSRISIRM 167
Query: 876 LATHHLALHEDK-----PDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRI--- 1031
L H L + + P +G I + ++++ D A+ LC+ Y +P + I
Sbjct: 168 LINQHTLLFDGRTNPAHPKHIGSIDPNCNVSEVVKDAYDMAKLLCDKYYMASPDLEIQEI 227
Query: 1032 ---NGHVAARFPFIPMPLDYILPELLKNAMRATMECHLDTPYNVPDVVITIANNGY*SRH 1202
N ++P L ++L EL KNAMRAT+E H ++ +P V + +A
Sbjct: 228 NASNSKQPIHMVYVPSHLYHMLFELFKNAMRATVESH-ESSVTLPPVKVMVALG------ 280
Query: 1203 QDF*PGWGNCSQRPGSGYGLPLHHGRGQYPGPPDQPSLRPPRHAQWQPVRTHARVRPHLA 1382
+ S++ P+R R+ ++
Sbjct: 281 --------------------------------EEDLSIKMSDRGGGVPLRKIDRLFSYMY 308
Query: 1383 GMEGWEAPGDSSL*GPCPVPLPIPSFGFGLPTSRAYAEYXXXXXXXXXXXXXXTDVYLQL 1562
PG P+ FG+GLP SR YA+Y TD + L
Sbjct: 309 STAPTPQPGTGG--------TPLAGFGYGLPISRLYAKYFQGDLQLFSMEGFGTDAVIYL 360
Query: 1563 R 1565
+
Sbjct: 361 K 361
>ref|NP_001095404.1| [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3, mitochondrial
[Bos taurus].
Length = 415
Score = 90.5 bits (223), Expect = 4e-18
Identities = 91/375 (24%), Positives = 155/375 (41%), Gaps = 23/375 (6%)
Frame = +3
Query: 537 SARYLQQELPVRIAHRIKDFRSLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEA 716
S +L++ELPVR+A+ +++ LP + P++ V Y+++F +L ++ + +
Sbjct: 45 SYMFLRKELPVRLANTMREVNLLPENLLNRPSVGLVQSWYMQSFLELLEYENKSPEDPQV 104
Query: 717 --QYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRS----FLDKTLTSRLGIRML 878
+ Q++ ++ + H DVV +A+G+ E ++ + + S FLD+ T+R+ RML
Sbjct: 105 LDNFLQVLIKVRNRHNDVVPTMAQGVIEYKEKFGFDPFISSNIQYFLDRFYTNRISFRML 164
Query: 879 ATHHLAL-----HEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHV 1043
H L + P +G I + +++ + A+ LCE Y AP + +
Sbjct: 165 INQHTLLFGGDTNPVHPKHIGSIDPTCNVADVVKDAYETAKMLCEQYYLVAPELEVEEFN 224
Query: 1044 AA------RFPFIPMPLDYILPELLKNAMRATMECHLDTPYNVPDV--VITIANNGY*SR 1199
A + ++P L ++L EL KN+MRAT+E + D P V ++T+ +
Sbjct: 225 AKAPNKPIQVVYVPSHLFHMLFELFKNSMRATVELYEDRKEGYPAVKTLVTLGKEDLSIK 284
Query: 1200 HQDF*PGWGNCSQRPGSGYGLPLHH----GRGQYPGPPDQPSLRPPRHAQWQPVRTHARV 1367
D G G+PL Y P +PSL P R A
Sbjct: 285 ISDL-------------GGGVPLRKIDRLFNYMYSTAP-RPSLEPTRAA----------- 319
Query: 1368 RPHLAGMEGWEAPGDSSL*GPCPVPLPIPSFGFGLPTSRAYAEYXXXXXXXXXXXXXXTD 1547
P+ FG+GLP SR YA Y TD
Sbjct: 320 --------------------------PLAGFGYGLPISRLYARYFQGDLKLYSMEGVGTD 353
Query: 1548 VYLQLRHIDGREESF 1592
+ L+ + ESF
Sbjct: 354 AVIYLKALS--SESF 366
>ref|NP_001095353.1| [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 4, mitochondrial
[Bos taurus].
Length = 407
Score = 85.1 bits (209), Expect = 2e-16
Identities = 60/230 (26%), Positives = 112/230 (48%), Gaps = 17/230 (7%)
Frame = +3
Query: 537 SARYLQQELPVRIAHRIKDFRSLPFIIGCNPTILHVHELYIRAFQKLTDF--PPIKDQAD 710
S +L+QELPVR+A+ +K+ LP + ++ V Y+++ +L +F +DQ
Sbjct: 48 SFAFLRQELPVRLANILKEIYILPDRLVNTSSVQLVKSWYMQSLMELVEFHEKSPEDQKA 107
Query: 711 EAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRS----FLDKTLTSRLGIRML 878
+ + + ++ + H DV+ +A+G+ E + + + FLD+ +R+ RML
Sbjct: 108 LSDFVDTLIKVRNRHHDVIPTMAQGILEYKDACTVDPVTNQNLQYFLDRFYMNRISTRML 167
Query: 879 ATHHLALHED----KPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVA 1046
H+ + D P +G I +++ + ++ LC+ Y +P + + V
Sbjct: 168 MNQHILIFGDLQTGNPSLIGSIDPNCDVAAVVQDAFECSKMLCDQYYLTSPELNLT-QVN 226
Query: 1047 ARFP-------FIPMPLDYILPELLKNAMRATMECHLDTPYNVPDVVITI 1175
+FP ++P L ++L EL KNAMRAT+E + P P VI +
Sbjct: 227 VKFPGQPIHIVYVPSHLHHMLFELFKNAMRATVEHQQNWPSLTPIQVIVV 276
>ref|NP_001069321.1| [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial
isoform 2 [Bos taurus].
Length = 343
Score = 82.4 bits (202), Expect = 1e-15
Identities = 78/345 (22%), Positives = 137/345 (39%), Gaps = 18/345 (5%)
Frame = +3
Query: 585 IKDFRSLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADE---AQYCQLVRQLLDDH 755
+K+ LP + P++ V Y+++ + +F KD D +Q+ + + + H
Sbjct: 1 MKEINLLPDRVLSTPSVQLVQSWYVQSLLDIMEFLD-KDPEDHRTLSQFTDALVTIRNRH 59
Query: 756 KDVVTLLAEGLRESRKHIEDEKL----VRSFLDKTLTSRLGIRMLATHHLALHEDK---- 911
DVV +A+G+ E + D+ + ++ FLD+ SR+ IRML H L + +
Sbjct: 60 NDVVPTMAQGVLEYKDTYGDDPVSNQNIQYFLDRFYLSRISIRMLINQHTLLFDGRTNPA 119
Query: 912 -PDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRI------NGHVAARFPFIPM 1070
P +G I + ++++ D A+ LC+ Y +P + I N ++P
Sbjct: 120 HPKHIGSIDPNCNVSEVVKDAYDMAKLLCDKYYMASPDLEIQEINASNSKQPIHMVYVPS 179
Query: 1071 PLDYILPELLKNAMRATMECHLDTPYNVPDVVITIANNGY*SRHQDF*PGWGNCSQRPGS 1250
L ++L EL KNAMRAT+E H ++ +P V + +A
Sbjct: 180 HLYHMLFELFKNAMRATVESH-ESSVTLPPVKVMVALG---------------------- 216
Query: 1251 GYGLPLHHGRGQYPGPPDQPSLRPPRHAQWQPVRTHARVRPHLAGMEGWEAPGDSSL*GP 1430
+ S++ P+R R+ ++ PG
Sbjct: 217 ----------------EEDLSIKMSDRGGGVPLRKIDRLFSYMYSTAPTPQPGTGG---- 256
Query: 1431 CPVPLPIPSFGFGLPTSRAYAEYXXXXXXXXXXXXXXTDVYLQLR 1565
P+ FG+GLP SR YA+Y TD + L+
Sbjct: 257 ----TPLAGFGYGLPISRLYAKYFQGDLQLFSMEGFGTDAVIYLK 297
Database: RefSeq49_BP.fasta
Posted date: Oct 17, 2011 1:42 PM
Number of letters in database: 17,681,374
Number of sequences in database: 33,088
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 33088
Number of Hits to DB: 81,772,885
Number of extensions: 2783937
Number of successful extensions: 15780
Number of sequences better than 1.0e-05: 7
Number of HSP's gapped: 15620
Number of HSP's successfully gapped: 16
Length of query: 601
Length of database: 17,681,374
Length adjustment: 108
Effective length of query: 493
Effective length of database: 14,107,870
Effective search space: 6955179910
Effective search space used: 6955179910
Neighboring words threshold: 12
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 36 (18.5 bits)
Search to RefSeqCP_Rel49
BLASTX 2.2.24 [Aug-08-2010]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= 20110601C-008065
(1804 letters)
Database: RefSeq49_CP.fasta
33,336 sequences; 18,874,504 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
Alignment gi|XP_536903.1| PREDICTED: similar to [3-methyl-2-oxobutanoate ... 583 e-166
Alignment gi|XP_534032.2| PREDICTED: similar to [Pyruvate dehydrogenase [... 95 1e-27
Alignment gi|XP_548195.2| PREDICTED: similar to pyruvate dehydrogenase ki... 96 1e-19
Alignment gi|XP_859771.1| PREDICTED: similar to [Pyruvate dehydrogenase [... 91 4e-18
Alignment gi|XP_537984.2| PREDICTED: similar to pyruvate dehydrogenase ki... 91 4e-18
Alignment gi|XP_539427.1| PREDICTED: similar to [Pyruvate dehydrogenase [... 83 8e-16
Alignment gi|XP_535965.2| PREDICTED: similar to [Pyruvate dehydrogenase [... 37 2e-10
>ref|XP_536903.1| PREDICTED: similar to [3-methyl-2-oxobutanoate dehydrogenase
[lipoamide]] kinase, mitochondrial precursor
(Branched-chain alpha-ketoacid dehydrogenase kinase)
(BCKDHKIN) (BCKD-kinase) [Canis familiaris].
Length = 510
Score = 583 bits (1504), Expect = e-166
Identities = 334/505 (66%), Positives = 352/505 (69%), Gaps = 5/505 (0%)
Frame = +3
Query: 99 GAAPWGLSLSASWTGPRP*SQEKSPC----AP-TPL*LPFGVASVCRVFSPSGCAVRQRS 263
G+ G L + P EKSP AP + L P + S + S +++
Sbjct: 37 GSCSLGAELVSILDLPSLLKSEKSPLPTHIAPCSVLGSPPSIRSSALAAAQSNKETKEQG 96
Query: 264 RTMMLASVXXXXXXXXXXXXXXXXXXXXXXXXXTSATDTHHVEMARERSKTVTSFYNQSA 443
R M+LASV TSATDTHHVEMARERSKTVTSFYNQSA
Sbjct: 97 RKMILASVLGSGPRSGPPLRPLLGPALSLRARSTSATDTHHVEMARERSKTVTSFYNQSA 156
Query: 444 IDAAAEKPSVRLTPTMMLYSGRSQDGSHLLKSARYLQQELPVRIAHRIKDFRSLPFIIGC 623
ID AAEKPSVRLTPTMMLYSGRSQDGSHLLKSARYLQQELPVRIAHRIK FRSLPFIIGC
Sbjct: 157 IDVAAEKPSVRLTPTMMLYSGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRSLPFIIGC 216
Query: 624 NPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRK 803
NPTILHVHELYIRAFQKLTDFP IKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRK
Sbjct: 217 NPTILHVHELYIRAFQKLTDFPLIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRK 276
Query: 804 HIEDEKLVRSFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFA 983
HI+DEKLVR FLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFA
Sbjct: 277 HIQDEKLVRFFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFA 336
Query: 984 RRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMECHLDTPYNVPDV 1163
RRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATME HLDTPYNVPDV
Sbjct: 337 RRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDV 396
Query: 1164 VITIANNGY*SRHQDF*PGWGNCSQRPGSGYGLPLHHGRGQYPGPPDQPSLRPPRHAQWQ 1343
VITIANN + S R G L Y + S + PR +
Sbjct: 397 VITIANNDIDLVIR--------ISDRGGGIAHKDLDRVM-DYHFTTAEASTQDPRIS--- 444
Query: 1344 PVRTHARVRPHLAGMEGWEAPGDSSL*GPCPVPLPIPSFGFGLPTSRAYAEYXXXXXXXX 1523
P+ H + H G G P+ FGFGLPTSRAYAEY
Sbjct: 445 PLFGHLDM--HSGGQSG-----------------PMHGFGFGLPTSRAYAEYLGGSLHLQ 485
Query: 1524 XXXXXXTDVYLQLRHIDGREESFRI 1598
TDVYL+LRHIDGREESFRI
Sbjct: 486 SLQGIGTDVYLRLRHIDGREESFRI 510
Score = 70.5 bits (171), Expect = 5e-12
Identities = 37/49 (75%), Positives = 38/49 (77%), Gaps = 2/49 (4%)
Frame = +2
Query: 44 VDCRAVPLGPR--P*LWPRDGSCSLGAELVSILDWPSPLKSREESLRTH 184
VDC AVPLGPR P WPRDGSCSLGAELVSILD PS LKS + L TH
Sbjct: 17 VDCWAVPLGPRARPWPWPRDGSCSLGAELVSILDLPSLLKSEKSPLPTH 65
>ref|XP_534032.2| PREDICTED: similar to [Pyruvate dehydrogenase [lipoamide]] kinase
isozyme 1, mitochondrial precursor (Pyruvate
dehydrogenase kinase isoform 1) [Canis familiaris].
Length = 369
Score = 95.1 bits (235), Expect(3) = 1e-27
Identities = 77/239 (32%), Positives = 125/239 (52%), Gaps = 24/239 (10%)
Frame = +3
Query: 537 SARYLQQELPVRIAHRIKDFRSLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQ-ADE 713
S +L+QELPVR+A+ +K+ LP + P++ V YI++ Q+L +F KD+ A+E
Sbjct: 8 SFMFLRQELPVRLANIMKEISLLPDNLLRTPSVQLVQSWYIQSLQELLEF---KDKSAEE 64
Query: 714 AQ----YCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKL----VRSFLDKTLTSRLGI 869
A+ + V ++ + H DV+ +A+G+ E ++ + + V+ FLD+ SR+ I
Sbjct: 65 AKTIYDFTDTVIRIRNRHNDVIPTMAQGVIEYKESFGVDPVTSQNVQYFLDRFYMSRISI 124
Query: 870 RMLATHHLALHEDK-------PDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVR 1028
RML H L K +G I ++I+ + ARRLC+ Y N+P +
Sbjct: 125 RMLLNQHSLLFGGKGKGSPAHRKHIGSINPNCDVVEVIKDGYENARRLCDLYYINSPELE 184
Query: 1029 INGHVAARFP-------FIPMPLDYILPELLKNAMRATMECHLDTPYNVP-DVVITIAN 1181
+ + A+ P ++P L +++ EL KNAMRATME H D P V IT+ N
Sbjct: 185 LE-ELNAKSPGQPIQVVYVPSHLYHMVFELFKNAMRATMEHHADKGVYPPIQVHITLGN 242
Score = 37.4 bits (85), Expect(3) = 1e-27
Identities = 17/44 (38%), Positives = 28/44 (63%), Gaps = 1/44 (2%)
Frame = +1
Query: 1192 DLVIRISDRGGGIAHKDLDRVMDYHFTTA-EASTQDPRISPLFG 1320
DL +++SDRGGG+ + +DR+ +Y ++TA + R PL G
Sbjct: 244 DLTVKMSDRGGGVPLRKIDRLFNYMYSTAPRPRVETSRAVPLAG 287
Score = 31.2 bits (69), Expect(3) = 1e-27
Identities = 13/41 (31%), Positives = 20/41 (48%)
Frame = +3
Query: 1443 LPIPSFGFGLPTSRAYAEYXXXXXXXXXXXXXXTDVYLQLR 1565
+P+ FG+GLP SR YA+Y TD + ++
Sbjct: 283 VPLAGFGYGLPISRLYAQYFQGDLKLYSLEGYGTDAVIYIK 323
>ref|XP_548195.2| PREDICTED: similar to pyruvate dehydrogenase kinase, isoenzyme 2
[Canis familiaris].
Length = 458
Score = 95.9 bits (237), Expect = 1e-19
Identities = 85/362 (23%), Positives = 149/362 (41%), Gaps = 19/362 (5%)
Frame = +3
Query: 537 SARYLQQELPVRIAHRIKDFRSLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADE- 713
S +L+QELPVR+A+ +K+ LP + P++ V Y+++ + +F KD D
Sbjct: 99 SFTFLRQELPVRLANIMKEINLLPDRVLSTPSVQLVQSWYVQSLLDIMEFLD-KDPEDHR 157
Query: 714 --AQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKL----VRSFLDKTLTSRLGIRM 875
+Q+ + + + H DVV +A+G+ E + D+ + ++ FLD+ SR+ IRM
Sbjct: 158 TLSQFTDALVTIRNRHNDVVPTMAQGVLEYKDTYGDDPVSNQNIQYFLDRFYLSRISIRM 217
Query: 876 LATHHLALHEDK-----PDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRI--- 1031
L H + + P +G I + ++++ D A+ LC+ Y +P + I
Sbjct: 218 LINQHTLIFDGSTNPAHPKHIGSIDPNCNVSEVVKDAYDMAKLLCDKYYMASPDLEIQEI 277
Query: 1032 ----NGHVAARFPFIPMPLDYILPELLKNAMRATMECHLDTPYNVPDVVITIANNGY*SR 1199
N ++P L ++L EL KNAMRAT+E H ++ +P + + +A
Sbjct: 278 NTASNSKQPIHMVYVPSHLYHMLFELFKNAMRATVESH-ESSLVLPPIKVMVALG----- 331
Query: 1200 HQDF*PGWGNCSQRPGSGYGLPLHHGRGQYPGPPDQPSLRPPRHAQWQPVRTHARVRPHL 1379
+ S++ P+R R+ ++
Sbjct: 332 ---------------------------------EEDLSIKMSDRGGGVPLRKIERLFSYM 358
Query: 1380 AGMEGWEAPGDSSL*GPCPVPLPIPSFGFGLPTSRAYAEYXXXXXXXXXXXXXXTDVYLQ 1559
PG P+ FG+GLP SR YA+Y TD +
Sbjct: 359 YSTAPTPQPGTGG--------TPLAGFGYGLPISRLYAKYFQGDLQLFSMEGFGTDAVIY 410
Query: 1560 LR 1565
L+
Sbjct: 411 LK 412
>ref|XP_859771.1| PREDICTED: similar to [Pyruvate dehydrogenase [lipoamide]] kinase
isozyme 3, mitochondrial precursor (Pyruvate
dehydrogenase kinase isoform 3) isoform 2 [Canis
familiaris].
Length = 406
Score = 90.9 bits (224), Expect = 4e-18
Identities = 91/375 (24%), Positives = 155/375 (41%), Gaps = 23/375 (6%)
Frame = +3
Query: 537 SARYLQQELPVRIAHRIKDFRSLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEA 716
S +L++ELPVR+A+ +++ LP + P++ V Y+++F +L ++ + +
Sbjct: 45 SYMFLRKELPVRLANTMREVNLLPDNLLNRPSVGLVQSWYMQSFLELLEYENKSPEDPQV 104
Query: 717 --QYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRS----FLDKTLTSRLGIRML 878
+ Q++ ++ + H DVV +A+G+ E ++ + + S FLD+ T+R+ RML
Sbjct: 105 LDNFLQVLIKVRNRHNDVVPTMAQGVIEYKEKFGFDPFISSNIQYFLDRFYTNRISFRML 164
Query: 879 ATHHLAL-----HEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHV 1043
H L + P +G I + +++ + A+ LCE Y AP + +
Sbjct: 165 INQHTLLFGGDTNPAHPKHIGSIDPTCNVADVVKDAYETAKMLCEQYYLVAPELEVEEFN 224
Query: 1044 AA------RFPFIPMPLDYILPELLKNAMRATMECHLDTPYNVPDV--VITIANNGY*SR 1199
A + ++P L ++L EL KN+MRAT+E + D P V ++T+ +
Sbjct: 225 AKAPDKPIQVVYVPSHLFHMLFELFKNSMRATVELYEDRKEGYPAVKTLVTLGKEDLSIK 284
Query: 1200 HQDF*PGWGNCSQRPGSGYGLPLHH----GRGQYPGPPDQPSLRPPRHAQWQPVRTHARV 1367
D G G+PL Y P +PSL P R A
Sbjct: 285 ISDL-------------GGGVPLRKIDRLFNYMYSTAP-RPSLEPTRAA----------- 319
Query: 1368 RPHLAGMEGWEAPGDSSL*GPCPVPLPIPSFGFGLPTSRAYAEYXXXXXXXXXXXXXXTD 1547
P+ FG+GLP SR YA Y TD
Sbjct: 320 --------------------------PLAGFGYGLPISRLYARYFQGDLKLYSMEGVGTD 353
Query: 1548 VYLQLRHIDGREESF 1592
+ L+ + ESF
Sbjct: 354 AVIYLKALS--SESF 366
>ref|XP_537984.2| PREDICTED: similar to pyruvate dehydrogenase kinase, isoenzyme 3
isoform 1 [Canis familiaris].
Length = 415
Score = 90.9 bits (224), Expect = 4e-18
Identities = 91/375 (24%), Positives = 155/375 (41%), Gaps = 23/375 (6%)
Frame = +3
Query: 537 SARYLQQELPVRIAHRIKDFRSLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEA 716
S +L++ELPVR+A+ +++ LP + P++ V Y+++F +L ++ + +
Sbjct: 45 SYMFLRKELPVRLANTMREVNLLPDNLLNRPSVGLVQSWYMQSFLELLEYENKSPEDPQV 104
Query: 717 --QYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRS----FLDKTLTSRLGIRML 878
+ Q++ ++ + H DVV +A+G+ E ++ + + S FLD+ T+R+ RML
Sbjct: 105 LDNFLQVLIKVRNRHNDVVPTMAQGVIEYKEKFGFDPFISSNIQYFLDRFYTNRISFRML 164
Query: 879 ATHHLAL-----HEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHV 1043
H L + P +G I + +++ + A+ LCE Y AP + +
Sbjct: 165 INQHTLLFGGDTNPAHPKHIGSIDPTCNVADVVKDAYETAKMLCEQYYLVAPELEVEEFN 224
Query: 1044 AA------RFPFIPMPLDYILPELLKNAMRATMECHLDTPYNVPDV--VITIANNGY*SR 1199
A + ++P L ++L EL KN+MRAT+E + D P V ++T+ +
Sbjct: 225 AKAPDKPIQVVYVPSHLFHMLFELFKNSMRATVELYEDRKEGYPAVKTLVTLGKEDLSIK 284
Query: 1200 HQDF*PGWGNCSQRPGSGYGLPLHH----GRGQYPGPPDQPSLRPPRHAQWQPVRTHARV 1367
D G G+PL Y P +PSL P R A
Sbjct: 285 ISDL-------------GGGVPLRKIDRLFNYMYSTAP-RPSLEPTRAA----------- 319
Query: 1368 RPHLAGMEGWEAPGDSSL*GPCPVPLPIPSFGFGLPTSRAYAEYXXXXXXXXXXXXXXTD 1547
P+ FG+GLP SR YA Y TD
Sbjct: 320 --------------------------PLAGFGYGLPISRLYARYFQGDLKLYSMEGVGTD 353
Query: 1548 VYLQLRHIDGREESF 1592
+ L+ + ESF
Sbjct: 354 AVIYLKALS--SESF 366
>ref|XP_539427.1| PREDICTED: similar to [Pyruvate dehydrogenase [lipoamide]] kinase
isozyme 4, mitochondrial precursor (Pyruvate
dehydrogenase kinase isoform 4) [Canis familiaris].
Length = 412
Score = 83.2 bits (204), Expect = 8e-16
Identities = 61/230 (26%), Positives = 112/230 (48%), Gaps = 17/230 (7%)
Frame = +3
Query: 537 SARYLQQELPVRIAHRIKDFRSLPFIIGCNPTILHVHELYIRAFQKLTDF--PPIKDQAD 710
S +L+QELPVR+A+ +K+ LP + ++ V YI++ L +F +DQ
Sbjct: 53 SFAFLRQELPVRLANILKEIDILPDRLVNTSSVQLVKSWYIQSLMDLVEFHEKSPEDQKA 112
Query: 711 EAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRS----FLDKTLTSRLGIRML 878
+ + + ++ + H +VV +A+G+ E + + + FLD+ +R+ RML
Sbjct: 113 LSDFTDTLIKVRNRHYNVVPTMAQGIIEYKDGCTVDPVTNQNLQYFLDRFYMNRISTRML 172
Query: 879 ATHHLALHEDK----PDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVA 1046
H+ + D P +G I +++ + ++ LC+ Y +P +++ V
Sbjct: 173 MNQHILIFSDSETGNPTHIGSIDPSCDVAAVVQDAFECSKMLCDQYYLTSPELKLT-QVN 231
Query: 1047 ARFP-------FIPMPLDYILPELLKNAMRATMECHLDTPYNVPDVVITI 1175
+FP ++P L ++L EL KNAMRAT+E + P P VI +
Sbjct: 232 GKFPGQPIHIVYVPSHLHHMLFELFKNAMRATVEHQENWPSLTPIEVIVV 281
>ref|XP_535965.2| PREDICTED: similar to [Pyruvate dehydrogenase [lipoamide]] kinase
isozyme 1, mitochondrial precursor (Pyruvate
dehydrogenase kinase isoform 1) [Canis familiaris].
Length = 323
Score = 37.4 bits (85), Expect(3) = 2e-10
Identities = 17/44 (38%), Positives = 28/44 (63%), Gaps = 1/44 (2%)
Frame = +1
Query: 1192 DLVIRISDRGGGIAHKDLDRVMDYHFTTA-EASTQDPRISPLFG 1320
DL +++SDRGGG+ + +DR+ +Y ++TA + R PL G
Sbjct: 198 DLTVKMSDRGGGVPLRKIDRLFNYMYSTAPRPRVETSRAVPLAG 241
Score = 35.4 bits (80), Expect(3) = 2e-10
Identities = 44/190 (23%), Positives = 75/190 (39%), Gaps = 5/190 (2%)
Frame = +3
Query: 627 PTILHVHELYIRAFQKLTDFPPIKDQADEAQ----YCQLVRQLLDDHKDVVTLLAEGLRE 794
P++ V YI++ +L +F A+EA+ + V Q+ + H DV+ +A+G+ E
Sbjct: 36 PSVQLVQSWYIQSLHELLEFKG--KSAEEAKTIYDFTDTVIQIRNRHNDVIPTMAQGVIE 93
Query: 795 SRKHIEDEKLVRSFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWV 974
++ + + + H+ D V +I
Sbjct: 94 YKESFGVDPVTSQNHSLLFGGKGKGSPAHRKHIGSMNPNCDVVEVI-------------- 139
Query: 975 DFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMECHLDTPYNV 1154
+ Y NA R I + ++P L +++ L +NAMRATME H D
Sbjct: 140 -------KDGYENARRQPI------QVVYVPSHLYHMVFGLFRNAMRATMEHHADKGVYA 186
Query: 1155 P-DVVITIAN 1181
P V IT+ N
Sbjct: 187 PIQVHITLGN 196
Score = 31.2 bits (69), Expect(3) = 2e-10
Identities = 13/41 (31%), Positives = 20/41 (48%)
Frame = +3
Query: 1443 LPIPSFGFGLPTSRAYAEYXXXXXXXXXXXXXXTDVYLQLR 1565
+P+ FG+GLP SR YA+Y TD + ++
Sbjct: 237 VPLAGFGYGLPISRLYAQYFQGNLKLYSLEGYGTDAVIYIK 277
Database: RefSeq49_CP.fasta
Posted date: Oct 17, 2011 1:42 PM
Number of letters in database: 18,874,504
Number of sequences in database: 33,336
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 33336
Number of Hits to DB: 85,111,241
Number of extensions: 2860323
Number of successful extensions: 17398
Number of sequences better than 1.0e-05: 7
Number of HSP's gapped: 17187
Number of HSP's successfully gapped: 17
Length of query: 601
Length of database: 18,874,504
Length adjustment: 109
Effective length of query: 492
Effective length of database: 15,240,880
Effective search space: 7498512960
Effective search space used: 7498512960
Neighboring words threshold: 12
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 36 (18.5 bits)
Search to RefSeqSP_Rel49
BLASTX 2.2.24 [Aug-08-2010]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= 20110601C-008065
(1804 letters)
Database: RefSeq49_SP.fasta
24,897 sequences; 11,343,932 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
Alignment gi|XP_003124519.1| PREDICTED: [3-methyl-2-oxobutanoate dehydrog... 582 e-166
Alignment gi|NP_001153080.1| [Pyruvate dehydrogenase [lipoamide]] kinase ... 96 3e-28
Alignment gi|XP_003358141.1| PREDICTED: [Pyruvate dehydrogenase [lipoamid... 92 3e-23
Alignment gi|XP_003131637.2| PREDICTED: [Pyruvate dehydrogenase [lipoamid... 92 3e-23
Alignment gi|XP_003360296.1| PREDICTED: [Pyruvate dehydrogenase [lipoamid... 91 2e-18
Alignment gi|XP_001927474.1| PREDICTED: [Pyruvate dehydrogenase [lipoamid... 91 2e-18
Alignment gi|NP_001152778.1| [Pyruvate dehydrogenase [lipoamide]] kinase ... 84 3e-16
>ref|XP_003124519.1| PREDICTED: [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]]
kinase, mitochondrial [Sus scrofa].
Length = 412
Score = 582 bits (1500), Expect = e-166
Identities = 320/454 (70%), Positives = 330/454 (72%), Gaps = 11/454 (2%)
Frame = +3
Query: 270 MMLASVXXXXXXXXXXXXXXXXXXXXXXXXXTSATDTHHVEMARERSKTVTSFYNQSAID 449
MMLASV TSATDTHHVEMARERSKTVTSFYNQSAID
Sbjct: 1 MMLASVLGSGPRGGPPLRPLLGPALSLRALSTSATDTHHVEMARERSKTVTSFYNQSAID 60
Query: 450 AAAEKPSVRLTPTMMLYSGRSQDGSHLLKSARYLQQELPVRIAHRIKDFRSLPFIIGCNP 629
AAAEKPSVRLTPTMMLYSGRSQDGSHLLKSARYLQQELPVRIAHRIKDFRSLPFIIGCNP
Sbjct: 61 AAAEKPSVRLTPTMMLYSGRSQDGSHLLKSARYLQQELPVRIAHRIKDFRSLPFIIGCNP 120
Query: 630 TILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHI 809
TILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHI
Sbjct: 121 TILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHI 180
Query: 810 EDEKLVRSFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARR 989
EDEKLVRSFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARR
Sbjct: 181 EDEKLVRSFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARR 240
Query: 990 LCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMECHLDTPYNVPDVV- 1166
LCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMECHLDTPYNVPDVV
Sbjct: 241 LCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMECHLDTPYNVPDVVI 300
Query: 1167 ----------ITIANNGY*SRHQDF*PGWGNCSQRPGSGYGLPLHHGRGQYPGPPDQPSL 1316
I I++ G H+D Y + S
Sbjct: 301 TIANNDIDLVIRISDRGGGIAHKDL--------------------DRVMDYHFTTAEAST 340
Query: 1317 RPPRHAQWQPVRTHARVRPHLAGMEGWEAPGDSSL*GPCPVPLPIPSFGFGLPTSRAYAE 1496
+ PR + P+ H + H G P+ FGFGLPTSRAYAE
Sbjct: 341 QDPRIS---PLFGHLDM--HSGSQSG-----------------PMHGFGFGLPTSRAYAE 378
Query: 1497 YXXXXXXXXXXXXXXTDVYLQLRHIDGREESFRI 1598
Y TDVYL+LRHIDGREESFRI
Sbjct: 379 YLGGSLRLQSLQGIGTDVYLRLRHIDGREESFRI 412
>ref|NP_001153080.1| [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial
[Sus scrofa].
Length = 438
Score = 95.9 bits (237), Expect(3) = 3e-28
Identities = 75/239 (31%), Positives = 123/239 (51%), Gaps = 24/239 (10%)
Frame = +3
Query: 537 SARYLQQELPVRIAHRIKDFRSLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADE- 713
S +L+QELPVR+A+ +K+ LP + P++ V YI++ Q+L DF KD++ E
Sbjct: 77 SFMFLRQELPVRLANIMKEISLLPDNLLRTPSVQLVQSWYIQSLQELLDF---KDKSAED 133
Query: 714 ----AQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKL----VRSFLDKTLTSRLGI 869
+ V ++ + H DV+ +A+G+ E ++ + + V+ FLD+ SR+ I
Sbjct: 134 AKTIYDFTDTVIRIRNRHNDVIPTMAQGVVEYKESFGVDPVTSQNVQYFLDRFYMSRISI 193
Query: 870 RMLATHHLALHEDK-------PDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVR 1028
RML H L K +G I + ++I+ + ARRLC+ Y N+P +
Sbjct: 194 RMLLNQHSLLFGGKGKGSLSHQKHIGSINPNCNVVEVIKDGYENARRLCDLYYINSPELE 253
Query: 1029 INGHVAARFP-------FIPMPLDYILPELLKNAMRATMECHLDTPYNVP-DVVITIAN 1181
+ + A+ P ++P L +++ EL KNAMRATME H D P V +T+ N
Sbjct: 254 LE-ELNAKSPGQPIQVVYVPSHLYHMVFELFKNAMRATMEHHADKGVYPPIQVHVTLGN 311
Score = 37.4 bits (85), Expect(3) = 3e-28
Identities = 17/44 (38%), Positives = 28/44 (63%), Gaps = 1/44 (2%)
Frame = +1
Query: 1192 DLVIRISDRGGGIAHKDLDRVMDYHFTTA-EASTQDPRISPLFG 1320
DL +++SDRGGG+ + +DR+ +Y ++TA + R PL G
Sbjct: 313 DLTVKMSDRGGGVPLRKIDRLFNYMYSTAPRPRVETSRAVPLAG 356
Score = 31.2 bits (69), Expect(3) = 3e-28
Identities = 13/41 (31%), Positives = 20/41 (48%)
Frame = +3
Query: 1443 LPIPSFGFGLPTSRAYAEYXXXXXXXXXXXXXXTDVYLQLR 1565
+P+ FG+GLP SR YA+Y TD + ++
Sbjct: 352 VPLAGFGYGLPISRLYAQYFQGDLKLYSLEGYGTDAVIYIK 392
>ref|XP_003358141.1| PREDICTED: [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2,
mitochondrial [Sus scrofa].
Length = 412
Score = 92.4 bits (228), Expect(2) = 3e-23
Identities = 62/231 (26%), Positives = 116/231 (50%), Gaps = 17/231 (7%)
Frame = +3
Query: 537 SARYLQQELPVRIAHRIKDFRSLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEA 716
S +L+QELPVR+A+ +K+ LP + P++ V Y+++ + +F + + A
Sbjct: 49 SFTFLRQELPVRLANIMKEINLLPDRVLSTPSVQLVQSWYVQSLLDIMEFLDKEPEPPRA 108
Query: 717 --QYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKL----VRSFLDKTLTSRLGIRML 878
++ + + + H DVV +A+G+ E + D+ + ++ FLD+ SR+ IRML
Sbjct: 109 CCRFTDALVTIRNRHNDVVPTMAQGVLEYKDAYGDDPVSNQNIQYFLDRFYLSRISIRML 168
Query: 879 ATHHLALHEDK-----PDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRI---- 1031
H + + P +G I + ++++ D A+ LC+ Y +P + I
Sbjct: 169 INQHTLIFDGSTNPAHPKHIGSIDPNCNVSEVVKDAYDMAKLLCDKYYMASPDLEIQEIN 228
Query: 1032 --NGHVAARFPFIPMPLDYILPELLKNAMRATMECHLDTPYNVPDVVITIA 1178
N ++P L ++L EL KNAMRAT+E H ++ +P + + +A
Sbjct: 229 ASNAKQPIHMVYVPSHLYHMLFELFKNAMRATVESH-ESSLTLPSIKVMVA 278
Score = 35.0 bits (79), Expect(2) = 3e-23
Identities = 16/43 (37%), Positives = 26/43 (60%)
Frame = +1
Query: 1192 DLVIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFG 1320
DL I++SDRGGG+ + ++R+ Y ++TA +PL G
Sbjct: 283 DLSIKMSDRGGGVPLRKIERLFSYMYSTAPTPQLGTGGTPLAG 325
>ref|XP_003131637.2| PREDICTED: [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2,
mitochondrial isoform 2 [Sus scrofa].
Length = 407
Score = 92.4 bits (228), Expect(2) = 3e-23
Identities = 62/231 (26%), Positives = 116/231 (50%), Gaps = 17/231 (7%)
Frame = +3
Query: 537 SARYLQQELPVRIAHRIKDFRSLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEA 716
S +L+QELPVR+A+ +K+ LP + P++ V Y+++ + +F + + A
Sbjct: 49 SFTFLRQELPVRLANIMKEINLLPDRVLSTPSVQLVQSWYVQSLLDIMEFLDKEPEPPRA 108
Query: 717 --QYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKL----VRSFLDKTLTSRLGIRML 878
++ + + + H DVV +A+G+ E + D+ + ++ FLD+ SR+ IRML
Sbjct: 109 CCRFTDALVTIRNRHNDVVPTMAQGVLEYKDAYGDDPVSNQNIQYFLDRFYLSRISIRML 168
Query: 879 ATHHLALHEDK-----PDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRI---- 1031
H + + P +G I + ++++ D A+ LC+ Y +P + I
Sbjct: 169 INQHTLIFDGSTNPAHPKHIGSIDPNCNVSEVVKDAYDMAKLLCDKYYMASPDLEIQEIN 228
Query: 1032 --NGHVAARFPFIPMPLDYILPELLKNAMRATMECHLDTPYNVPDVVITIA 1178
N ++P L ++L EL KNAMRAT+E H ++ +P + + +A
Sbjct: 229 ASNAKQPIHMVYVPSHLYHMLFELFKNAMRATVESH-ESSLTLPSIKVMVA 278
Score = 35.0 bits (79), Expect(2) = 3e-23
Identities = 16/43 (37%), Positives = 26/43 (60%)
Frame = +1
Query: 1192 DLVIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFG 1320
DL I++SDRGGG+ + ++R+ Y ++TA +PL G
Sbjct: 283 DLSIKMSDRGGGVPLRKIERLFSYMYSTAPTPQLGTGGTPLAG 325
>ref|XP_003360296.1| PREDICTED: [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3,
mitochondrial isoform 2 [Sus scrofa].
Length = 406
Score = 90.9 bits (224), Expect = 2e-18
Identities = 91/375 (24%), Positives = 155/375 (41%), Gaps = 23/375 (6%)
Frame = +3
Query: 537 SARYLQQELPVRIAHRIKDFRSLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEA 716
S +L++ELPVR+A+ +++ LP + P++ V Y+++F +L ++ + +
Sbjct: 45 SYMFLRKELPVRLANTMREVNLLPDNLLNRPSVGLVQSWYMQSFLELLEYENKSPEDPQV 104
Query: 717 --QYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRS----FLDKTLTSRLGIRML 878
+ Q++ ++ + H DVV +A+G+ E ++ + + S FLD+ T+R+ RML
Sbjct: 105 LDNFLQVLIKVRNRHNDVVPTMAQGVIEYKEKFGFDPFISSNIQYFLDRFYTNRISFRML 164
Query: 879 ATHHLAL-----HEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHV 1043
H L + P +G I + +++ + A+ LCE Y AP + +
Sbjct: 165 INQHTLLFGGDTNPAHPKHIGSIDPTCNVADVVKDAYETAKMLCEQYYLVAPELEVEEFN 224
Query: 1044 AA------RFPFIPMPLDYILPELLKNAMRATMECHLDTPYNVPDV--VITIANNGY*SR 1199
A + ++P L ++L EL KN+MRAT+E + D P V ++T+ +
Sbjct: 225 AKAPNKPIQVVYVPSHLFHMLFELFKNSMRATVELYEDRKEGYPAVKTLVTLGKEDLSIK 284
Query: 1200 HQDF*PGWGNCSQRPGSGYGLPLHH----GRGQYPGPPDQPSLRPPRHAQWQPVRTHARV 1367
D G G+PL Y P +PSL P R A
Sbjct: 285 ISDL-------------GGGVPLRKIDRLFNYMYSTAP-RPSLEPTRAA----------- 319
Query: 1368 RPHLAGMEGWEAPGDSSL*GPCPVPLPIPSFGFGLPTSRAYAEYXXXXXXXXXXXXXXTD 1547
P+ FG+GLP SR YA Y TD
Sbjct: 320 --------------------------PLAGFGYGLPISRLYARYFQGDLKLYSMEGVGTD 353
Query: 1548 VYLQLRHIDGREESF 1592
+ L+ + ESF
Sbjct: 354 AVIYLKALS--SESF 366
>ref|XP_001927474.1| PREDICTED: [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3,
mitochondrial isoform 1 [Sus scrofa].
Length = 415
Score = 90.9 bits (224), Expect = 2e-18
Identities = 91/375 (24%), Positives = 155/375 (41%), Gaps = 23/375 (6%)
Frame = +3
Query: 537 SARYLQQELPVRIAHRIKDFRSLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEA 716
S +L++ELPVR+A+ +++ LP + P++ V Y+++F +L ++ + +
Sbjct: 45 SYMFLRKELPVRLANTMREVNLLPDNLLNRPSVGLVQSWYMQSFLELLEYENKSPEDPQV 104
Query: 717 --QYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRS----FLDKTLTSRLGIRML 878
+ Q++ ++ + H DVV +A+G+ E ++ + + S FLD+ T+R+ RML
Sbjct: 105 LDNFLQVLIKVRNRHNDVVPTMAQGVIEYKEKFGFDPFISSNIQYFLDRFYTNRISFRML 164
Query: 879 ATHHLAL-----HEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHV 1043
H L + P +G I + +++ + A+ LCE Y AP + +
Sbjct: 165 INQHTLLFGGDTNPAHPKHIGSIDPTCNVADVVKDAYETAKMLCEQYYLVAPELEVEEFN 224
Query: 1044 AA------RFPFIPMPLDYILPELLKNAMRATMECHLDTPYNVPDV--VITIANNGY*SR 1199
A + ++P L ++L EL KN+MRAT+E + D P V ++T+ +
Sbjct: 225 AKAPNKPIQVVYVPSHLFHMLFELFKNSMRATVELYEDRKEGYPAVKTLVTLGKEDLSIK 284
Query: 1200 HQDF*PGWGNCSQRPGSGYGLPLHH----GRGQYPGPPDQPSLRPPRHAQWQPVRTHARV 1367
D G G+PL Y P +PSL P R A
Sbjct: 285 ISDL-------------GGGVPLRKIDRLFNYMYSTAP-RPSLEPTRAA----------- 319
Query: 1368 RPHLAGMEGWEAPGDSSL*GPCPVPLPIPSFGFGLPTSRAYAEYXXXXXXXXXXXXXXTD 1547
P+ FG+GLP SR YA Y TD
Sbjct: 320 --------------------------PLAGFGYGLPISRLYARYFQGDLKLYSMEGVGTD 353
Query: 1548 VYLQLRHIDGREESF 1592
+ L+ + ESF
Sbjct: 354 AVIYLKALS--SESF 366
>ref|NP_001152778.1| [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 4, mitochondrial
[Sus scrofa].
Length = 407
Score = 84.0 bits (206), Expect = 3e-16
Identities = 61/229 (26%), Positives = 114/229 (49%), Gaps = 16/229 (6%)
Frame = +3
Query: 537 SARYLQQELPVRIAHRIKDFRSLPFIIGCNPTILHVHELYIRAFQKLTDF--PPIKDQAD 710
S +L+QELPVR+A+ +K+ LP + ++ V YI++ +L +F +DQ
Sbjct: 48 SFAFLRQELPVRLANILKEIYILPDRLVNTSSVQLVKSWYIQSLMELVEFHEKSPEDQKV 107
Query: 711 EAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKL----VRSFLDKTLTSRLGIRML 878
A + + ++ + H +VV +A+G+ E + + + ++ FLD+ +R+ RML
Sbjct: 108 LADFVDTLIKVRNRHHNVVPTMAQGILEYKDACTVDPVTNQNLQYFLDRFYMNRISTRML 167
Query: 879 ATHHLALHED----KPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVR---ING 1037
H+ + D P +G I +++ + ++ LC Y +P ++ +NG
Sbjct: 168 MNQHILIFSDLQTANPSHIGSIDPNCDVAAVVQDAFECSKMLCNQYYLTSPELKLTQVNG 227
Query: 1038 HVAAR---FPFIPMPLDYILPELLKNAMRATMECHLDTPYNVPDVVITI 1175
+ + ++P L ++L EL KNAMRAT+E + P P VI +
Sbjct: 228 KLPGQPIHIVYVPSHLHHMLFELFKNAMRATVEHQENWPSLTPIEVIVV 276
Database: RefSeq49_SP.fasta
Posted date: Oct 17, 2011 1:42 PM
Number of letters in database: 11,343,932
Number of sequences in database: 24,897
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 24897
Number of Hits to DB: 52,887,895
Number of extensions: 1805235
Number of successful extensions: 10411
Number of sequences better than 1.0e-05: 7
Number of HSP's gapped: 10213
Number of HSP's successfully gapped: 15
Length of query: 601
Length of database: 11,343,932
Length adjustment: 105
Effective length of query: 496
Effective length of database: 8,729,747
Effective search space: 4329954512
Effective search space used: 4329954512
Neighboring words threshold: 12
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 35 (18.1 bits)
Search to RefSeqMP_Rel49
BLASTX 2.2.24 [Aug-08-2010]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= 20110601C-008065
(1804 letters)
Database: RefSeq49_MP.fasta
30,036 sequences; 15,617,559 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
Alignment gi|NP_033869.1| [3-methyl-2-oxobutanoate dehydrogenase [lipoami... 580 e-165
Alignment gi|NP_766253.2| pyruvate dehydrogenase kinase, isozyme 1 precur... 97 3e-28
Alignment gi|NP_598428.2| pyruvate dehydrogenase kinase, isoenzyme 2 prec... 98 2e-20
Alignment gi|NP_663605.1| pyruvate dehydrogenase kinase, isozyme 3 precur... 91 4e-18
Alignment gi|NP_038771.1| pyruvate dehydrogenase kinase, isozyme 4 precur... 87 4e-17
>ref|NP_033869.1| [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase,
mitochondrial precursor [Mus musculus].
Length = 412
Score = 580 bits (1494), Expect = e-165
Identities = 313/412 (75%), Positives = 322/412 (78%)
Frame = +3
Query: 363 TSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYSGRSQDGSHLLKSA 542
TSATDTHHVE+ARERSKTVTSFYNQSAID AAEKPSVRLTPTMMLYSGRSQDGSHLLKS
Sbjct: 32 TSATDTHHVELARERSKTVTSFYNQSAIDVAAEKPSVRLTPTMMLYSGRSQDGSHLLKSG 91
Query: 543 RYLQQELPVRIAHRIKDFRSLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQY 722
RYLQQELPVRIAHRIK FRSLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQY
Sbjct: 92 RYLQQELPVRIAHRIKGFRSLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQY 151
Query: 723 CQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRSFLDKTLTSRLGIRMLATHHLALH 902
CQLVRQLLDDHKDVVTLLAEGLRESRKHI+DEKLVR FLDKTLTSRLGIRMLATHHLALH
Sbjct: 152 CQLVRQLLDDHKDVVTLLAEGLRESRKHIQDEKLVRYFLDKTLTSRLGIRMLATHHLALH 211
Query: 903 EDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDY 1082
EDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDY
Sbjct: 212 EDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDY 271
Query: 1083 ILPELLKNAMRATMECHLDTPYNVPDVVITIANNGY*SRHQDF*PGWGNCSQRPGSGYGL 1262
ILPELLKNAMRATME HLDTPYNVPDVVITIANN + S R G
Sbjct: 272 ILPELLKNAMRATMESHLDTPYNVPDVVITIANNDIDLIIR--------ISDRGGGIAHK 323
Query: 1263 PLHHGRGQYPGPPDQPSLRPPRHAQWQPVRTHARVRPHLAGMEGWEAPGDSSL*GPCPVP 1442
L Y + S + PR P+ H + H G G
Sbjct: 324 DLDRVM-DYHFTTAEASTQDPR---INPLFGHLDM--HSGGQSG---------------- 361
Query: 1443 LPIPSFGFGLPTSRAYAEYXXXXXXXXXXXXXXTDVYLQLRHIDGREESFRI 1598
P+ FGFGLPTSRAYAEY TDVYL+LRHIDGREESFRI
Sbjct: 362 -PMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 412
>ref|NP_766253.2| pyruvate dehydrogenase kinase, isozyme 1 precursor [Mus musculus].
Length = 434
Score = 96.7 bits (239), Expect(3) = 3e-28
Identities = 71/222 (31%), Positives = 117/222 (52%), Gaps = 21/222 (9%)
Frame = +3
Query: 537 SARYLQQELPVRIAHRIKDFRSLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADE- 713
S +L+QELPVR+A+ +K+ LP + P++ V YI++ Q+L DF KD++ E
Sbjct: 75 SFMFLRQELPVRLANIMKEISLLPDNLLRTPSVQLVQSWYIQSLQELLDF---KDKSAED 131
Query: 714 ----AQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKL----VRSFLDKTLTSRLGI 869
++ V ++ + H DV+ +A+G+ E ++ + + V+ FLD+ SR+ I
Sbjct: 132 AKTIYEFTDTVIRIRNRHNDVIPTMAQGVTEYKESFGVDPVTSQNVQYFLDRFYMSRISI 191
Query: 870 RMLATHHLALHEDKPD-----FVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRIN 1034
RML H L K +G I ++I+ + ARRLC+ Y N+P + +
Sbjct: 192 RMLLNQHSLLFGGKGSPSHRKHIGSINPNCDVVEVIKDGYENARRLCDLYYVNSPELELE 251
Query: 1035 GHVAARFP-------FIPMPLDYILPELLKNAMRATMECHLD 1139
+ A+ P ++P L +++ EL KNAMRATME H D
Sbjct: 252 -ELNAKSPGQTIQVVYVPSHLYHMVFELFKNAMRATMEHHAD 292
Score = 37.4 bits (85), Expect(3) = 3e-28
Identities = 17/44 (38%), Positives = 28/44 (63%), Gaps = 1/44 (2%)
Frame = +1
Query: 1192 DLVIRISDRGGGIAHKDLDRVMDYHFTTA-EASTQDPRISPLFG 1320
DL +++SDRGGG+ + +DR+ +Y ++TA + R PL G
Sbjct: 309 DLTVKMSDRGGGVPLRKIDRLFNYMYSTAPRPRVETSRAVPLAG 352
Score = 31.2 bits (69), Expect(3) = 3e-28
Identities = 13/41 (31%), Positives = 20/41 (48%)
Frame = +3
Query: 1443 LPIPSFGFGLPTSRAYAEYXXXXXXXXXXXXXXTDVYLQLR 1565
+P+ FG+GLP SR YA+Y TD + ++
Sbjct: 348 VPLAGFGYGLPISRLYAQYFQGDLKLYSLEGYGTDAVIYIK 388
>ref|NP_598428.2| pyruvate dehydrogenase kinase, isoenzyme 2 precursor [Mus musculus].
Length = 407
Score = 98.2 bits (243), Expect = 2e-20
Identities = 87/361 (24%), Positives = 149/361 (41%), Gaps = 18/361 (4%)
Frame = +3
Query: 537 SARYLQQELPVRIAHRIKDFRSLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADE- 713
S +L+QELPVR+A+ +K+ LP + P++ V Y+++ + +F KD D
Sbjct: 49 SFTFLRQELPVRLANIMKEINLLPDRVLGTPSVQLVQSWYVQSLLDIMEFLD-KDPEDHR 107
Query: 714 --AQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKL----VRSFLDKTLTSRLGIRM 875
+Q+ + + + H DVV +A+G+ E + D+ + ++ FLD+ SR+ IRM
Sbjct: 108 TLSQFTDALVTIRNRHNDVVPTMAQGVLEYKDTYGDDPVSNQNIQYFLDRFYLSRISIRM 167
Query: 876 LATHHLALHEDK-----PDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRI--- 1031
L H + + P +G I S +++ D A+ LC+ Y +P + I
Sbjct: 168 LINQHTLIFDGSTNPAHPKHIGSIDPNCSVSDVVKDAYDMAKLLCDKYYMASPDLEIQEV 227
Query: 1032 ---NGHVAARFPFIPMPLDYILPELLKNAMRATMECHLDTPYNVPDVVITIANNGY*SRH 1202
N + ++P L ++L EL KNAMRAT+E H ++ +P + I +A
Sbjct: 228 NATNANQPIHMVYVPSHLYHMLFELFKNAMRATVESH-ESSLTLPPIKIMVALG------ 280
Query: 1203 QDF*PGWGNCSQRPGSGYGLPLHHGRGQYPGPPDQPSLRPPRHAQWQPVRTHARVRPHLA 1382
+ S++ P+R R+ ++
Sbjct: 281 --------------------------------EEDLSIKMSDRGGGVPLRKIERLFSYMY 308
Query: 1383 GMEGWEAPGDSSL*GPCPVPLPIPSFGFGLPTSRAYAEYXXXXXXXXXXXXXXTDVYLQL 1562
PG P+ FG+GLP SR YA+Y TD + L
Sbjct: 309 STAPTPQPGTGG--------TPLAGFGYGLPISRLYAKYFQGDLQLFSMEGFGTDAVIYL 360
Query: 1563 R 1565
+
Sbjct: 361 K 361
>ref|NP_663605.1| pyruvate dehydrogenase kinase, isozyme 3 precursor [Mus musculus].
Length = 415
Score = 90.5 bits (223), Expect = 4e-18
Identities = 91/375 (24%), Positives = 152/375 (40%), Gaps = 23/375 (6%)
Frame = +3
Query: 537 SARYLQQELPVRIAHRIKDFRSLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEA 716
S +L++ELPVR+A+ +++ LP + P++ V Y+++F +L ++ +
Sbjct: 45 SYMFLRKELPVRLANTMREVNLLPDNLLNRPSVGLVQSWYMQSFLELLEYENKSPEDPRV 104
Query: 717 --QYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRS----FLDKTLTSRLGIRML 878
+ ++ + + H DVV +A+G+ E ++ + + S FLD+ T+R+ RML
Sbjct: 105 LDNFLNVLINIRNRHNDVVPTMAQGVIEYKEKFGFDPFISSNIQYFLDRFYTNRISFRML 164
Query: 879 ATHHLAL-----HEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHV 1043
H L + P +G I + +++ + A+ LCE Y AP + +
Sbjct: 165 INQHTLLFGGDTNPAHPKHIGSIDPTCNVADVVKDAYETAKMLCEQYYLVAPELEVEEFN 224
Query: 1044 AA------RFPFIPMPLDYILPELLKNAMRATMECHLDTPYNVPDV--VITIANNGY*SR 1199
A + ++P L ++L EL KN+MRAT+E H D P V ++T+ +
Sbjct: 225 AKAPNKPIQVVYVPSHLFHMLFELFKNSMRATVELHEDKKEGYPAVKTLVTLGKEDLSIK 284
Query: 1200 HQDF*PGWGNCSQRPGSGYGLPLHH----GRGQYPGPPDQPSLRPPRHAQWQPVRTHARV 1367
D G G+PL Y P +PSL P R A
Sbjct: 285 ISDL-------------GGGVPLRKIDRLFNYMYSTAP-RPSLEPTRAA----------- 319
Query: 1368 RPHLAGMEGWEAPGDSSL*GPCPVPLPIPSFGFGLPTSRAYAEYXXXXXXXXXXXXXXTD 1547
P+ FG+GLP SR YA Y TD
Sbjct: 320 --------------------------PLAGFGYGLPISRLYARYFQGDLKLYSMEGVGTD 353
Query: 1548 VYLQLRHIDGREESF 1592
+ L+ + ESF
Sbjct: 354 AVIYLKALS--SESF 366
>ref|NP_038771.1| pyruvate dehydrogenase kinase, isozyme 4 precursor [Mus musculus].
Length = 412
Score = 87.0 bits (214), Expect = 4e-17
Identities = 65/244 (26%), Positives = 119/244 (48%), Gaps = 27/244 (11%)
Frame = +3
Query: 537 SARYLQQELPVRIAHRIKDFRSLPFIIGCNPTILHVHELYIRAFQKLTDF--PPIKDQAD 710
S +L+QELPVR+A+ +K+ LP + P++ V YI++ L +F +DQ
Sbjct: 53 SFAFLRQELPVRLANILKEIDILPDRLVNTPSVQLVKSWYIQSLMDLVEFHEKSPEDQKA 112
Query: 711 EAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKL----VRSFLDKTLTSRLGIRML 878
+++ + ++ + H +VV +A+G+ E + + + ++ FLD+ +R+ RML
Sbjct: 113 LSEFVDTLVKVRNRHHNVVPTMAQGILEYKDTCTVDPVTNQNLQYFLDRFYMNRISTRML 172
Query: 879 ATHHLALHED----KPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVA 1046
H+ + D P +G I +++ + A+ LC+ Y +P + + V
Sbjct: 173 MNQHILIFSDSKTGNPSHIGSIDPNCDVVAVVQDAFECAKMLCDQYYLTSPELNLT-QVN 231
Query: 1047 ARFP-------FIPMPLDYILPELLKNAMRATMECHLDTPYNVP----------DVVITI 1175
+FP ++P L ++L EL KNAMRAT+E + P P D+ I I
Sbjct: 232 GKFPGQPIHIVYVPSHLHHMLFELFKNAMRATVEHQENRPSLTPVEATVVLGKEDLTIKI 291
Query: 1176 ANNG 1187
++ G
Sbjct: 292 SDRG 295
Database: RefSeq49_MP.fasta
Posted date: Oct 17, 2011 1:42 PM
Number of letters in database: 15,617,559
Number of sequences in database: 30,036
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 30036
Number of Hits to DB: 69,875,319
Number of extensions: 2274729
Number of successful extensions: 12177
Number of sequences better than 1.0e-05: 5
Number of HSP's gapped: 12028
Number of HSP's successfully gapped: 11
Length of query: 601
Length of database: 15,617,559
Length adjustment: 107
Effective length of query: 494
Effective length of database: 12,403,707
Effective search space: 6127431258
Effective search space used: 6127431258
Neighboring words threshold: 12
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 36 (18.5 bits)
Search to RefSeqHP_Rel49
BLASTX 2.2.24 [Aug-08-2010]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= 20110601C-008065
(1804 letters)
Database: RefSeq49_HP.fasta
32,964 sequences; 18,297,164 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
Alignment gi|NP_001116429.1| [3-methyl-2-oxobutanoate dehydrogenase [lipo... 543 0.0
Alignment gi|NP_005872.2| [3-methyl-2-oxobutanoate dehydrogenase [lipoami... 570 e-162
Alignment gi|NP_002601.1| pyruvate dehydrogenase kinase, isozyme 1 precur... 94 3e-27
Alignment gi|NP_002603.1| pyruvate dehydrogenase kinase, isozyme 4 precur... 86 2e-22
Alignment gi|NP_002602.2| pyruvate dehydrogenase kinase, isozyme 2 isofor... 96 8e-20
Alignment gi|NP_005382.1| pyruvate dehydrogenase kinase, isozyme 3 isofor... 89 1e-17
Alignment gi|NP_001135858.1| pyruvate dehydrogenase kinase, isozyme 3 iso... 89 1e-17
Alignment gi|NP_001186828.1| pyruvate dehydrogenase kinase, isozyme 2 iso... 80 8e-15
Alignment gi|NP_001186827.1| pyruvate dehydrogenase kinase, isozyme 2 iso... 80 8e-15
Alignment gi|NP_001186829.1| pyruvate dehydrogenase kinase, isozyme 2 iso... 60 9e-09
>ref|NP_001116429.1| [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase,
mitochondrial isoform b [Homo sapiens].
Length = 365
Score = 543 bits (1399), Expect(2) = 0.0
Identities = 269/274 (98%), Positives = 270/274 (98%)
Frame = +3
Query: 363 TSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYSGRSQDGSHLLKSA 542
TSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLY+GRSQDGSHLLKSA
Sbjct: 32 TSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSA 91
Query: 543 RYLQQELPVRIAHRIKDFRSLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQY 722
RYLQQELPVRIAHRIK FR LPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQY
Sbjct: 92 RYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQY 151
Query: 723 CQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRSFLDKTLTSRLGIRMLATHHLALH 902
CQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVR FLDKTLTSRLGIRMLATHHLALH
Sbjct: 152 CQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALH 211
Query: 903 EDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDY 1082
EDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDY
Sbjct: 212 EDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDY 271
Query: 1083 ILPELLKNAMRATMECHLDTPYNVPDVVITIANN 1184
ILPELLKNAMRATME HLDTPYNVPDVVITIANN
Sbjct: 272 ILPELLKNAMRATMESHLDTPYNVPDVVITIANN 305
Score = 125 bits (315), Expect(2) = 0.0
Identities = 57/60 (95%), Positives = 60/60 (100%)
Frame = +1
Query: 1186 DIDLVIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGSQSGPMHG 1365
D+DL+IRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSG+QSGPMHG
Sbjct: 306 DVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHG 365
>ref|NP_005872.2| [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase,
mitochondrial isoform a [Homo sapiens].
Length = 412
Score = 570 bits (1468), Expect = e-162
Identities = 309/423 (73%), Positives = 320/423 (75%), Gaps = 11/423 (2%)
Frame = +3
Query: 363 TSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYSGRSQDGSHLLKSA 542
TSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLY+GRSQDGSHLLKSA
Sbjct: 32 TSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSA 91
Query: 543 RYLQQELPVRIAHRIKDFRSLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQY 722
RYLQQELPVRIAHRIK FR LPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQY
Sbjct: 92 RYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQY 151
Query: 723 CQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRSFLDKTLTSRLGIRMLATHHLALH 902
CQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVR FLDKTLTSRLGIRMLATHHLALH
Sbjct: 152 CQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALH 211
Query: 903 EDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDY 1082
EDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDY
Sbjct: 212 EDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDY 271
Query: 1083 ILPELLKNAMRATMECHLDTPYNVPDVV-----------ITIANNGY*SRHQDF*PGWGN 1229
ILPELLKNAMRATME HLDTPYNVPDVV I I++ G H+D
Sbjct: 272 ILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDL------ 325
Query: 1230 CSQRPGSGYGLPLHHGRGQYPGPPDQPSLRPPRHAQWQPVRTHARVRPHLAGMEGWEAPG 1409
Y + S + PR + P+ H + H G
Sbjct: 326 --------------DRVMDYHFTTAEASTQDPRIS---PLFGHLDM--HSGAQSG----- 361
Query: 1410 DSSL*GPCPVPLPIPSFGFGLPTSRAYAEYXXXXXXXXXXXXXXTDVYLQLRHIDGREES 1589
P+ FGFGLPTSRAYAEY TDVYL+LRHIDGREES
Sbjct: 362 ------------PMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREES 409
Query: 1590 FRI 1598
FRI
Sbjct: 410 FRI 412
>ref|NP_002601.1| pyruvate dehydrogenase kinase, isozyme 1 precursor [Homo sapiens].
Length = 436
Score = 93.6 bits (231), Expect(3) = 3e-27
Identities = 74/239 (30%), Positives = 123/239 (51%), Gaps = 24/239 (10%)
Frame = +3
Query: 537 SARYLQQELPVRIAHRIKDFRSLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADE- 713
S +L+QELPVR+A+ +K+ LP + P++ V YI++ Q+L DF KD++ E
Sbjct: 75 SFMFLRQELPVRLANIMKEISLLPDNLLRTPSVQLVQSWYIQSLQELLDF---KDKSAED 131
Query: 714 ----AQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKL----VRSFLDKTLTSRLGI 869
+ V ++ + H DV+ +A+G+ E ++ + + V+ FLD+ SR+ I
Sbjct: 132 AKAIYDFTDTVIRIRNRHNDVIPTMAQGVIEYKESFGVDPVTSQNVQYFLDRFYMSRISI 191
Query: 870 RMLATHHLALHEDK-------PDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVR 1028
RML H L K +G I + ++I+ + ARRLC+ Y N+P +
Sbjct: 192 RMLLNQHSLLFGGKGKGSPSHRKHIGSINPNCNVLEVIKDGYENARRLCDLYYINSPELE 251
Query: 1029 INGHVAARFP-------FIPMPLDYILPELLKNAMRATMECHLDTPYNVP-DVVITIAN 1181
+ + A+ P ++P L +++ EL KNAMRATME H + P V +T+ N
Sbjct: 252 LE-ELNAKSPGQPIQVVYVPSHLYHMVFELFKNAMRATMEHHANRGVYPPIQVHVTLGN 309
Score = 37.4 bits (85), Expect(3) = 3e-27
Identities = 17/44 (38%), Positives = 28/44 (63%), Gaps = 1/44 (2%)
Frame = +1
Query: 1192 DLVIRISDRGGGIAHKDLDRVMDYHFTTA-EASTQDPRISPLFG 1320
DL +++SDRGGG+ + +DR+ +Y ++TA + R PL G
Sbjct: 311 DLTVKMSDRGGGVPLRKIDRLFNYMYSTAPRPRVETSRAVPLAG 354
Score = 31.2 bits (69), Expect(3) = 3e-27
Identities = 13/41 (31%), Positives = 20/41 (48%)
Frame = +3
Query: 1443 LPIPSFGFGLPTSRAYAEYXXXXXXXXXXXXXXTDVYLQLR 1565
+P+ FG+GLP SR YA+Y TD + ++
Sbjct: 350 VPLAGFGYGLPISRLYAQYFQGDLKLYSLEGYGTDAVIYIK 390
>ref|NP_002603.1| pyruvate dehydrogenase kinase, isozyme 4 precursor [Homo sapiens].
Length = 411
Score = 85.5 bits (210), Expect(2) = 2e-22
Identities = 62/230 (26%), Positives = 112/230 (48%), Gaps = 17/230 (7%)
Frame = +3
Query: 537 SARYLQQELPVRIAHRIKDFRSLPFIIGCNPTILHVHELYIRAFQKLTDFPPIK--DQAD 710
S +L+QELPVR+A+ +K+ LP + ++ V YI++ L +F DQ
Sbjct: 53 SFAFLRQELPVRLANILKEIDILPTQLVNTSSVQLVKSWYIQSLMDLVEFHEKSPDDQKA 112
Query: 711 EAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRS----FLDKTLTSRLGIRML 878
+ + + ++ + H +VV +A+G+ E + + + FLD+ +R+ RML
Sbjct: 113 LSDFVDTLIKVRNRHHNVVPTMAQGIIEYKDACTVDPVTNQNLQYFLDRFYMNRISTRML 172
Query: 879 ATHHLALHEDK----PDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVA 1046
H+ + D P +G I +++ + +R LC+ Y ++P +++ V
Sbjct: 173 MNQHILIFSDSQTGNPSHIGSIDPNCDVVAVVQDAFECSRMLCDQYYLSSPELKLT-QVN 231
Query: 1047 ARFP-------FIPMPLDYILPELLKNAMRATMECHLDTPYNVPDVVITI 1175
+FP ++P L ++L EL KNAMRAT+E + P P VI +
Sbjct: 232 GKFPDQPIHIVYVPSHLHHMLFELFKNAMRATVEHQENQPSLTPIEVIVV 281
Score = 40.0 bits (92), Expect(2) = 2e-22
Identities = 20/44 (45%), Positives = 28/44 (63%), Gaps = 1/44 (2%)
Frame = +1
Query: 1192 DLVIRISDRGGGIAHKDLDRVMDYHFTTAEASTQD-PRISPLFG 1320
DL I+ISDRGGG+ + +DR+ Y ++TA D R +PL G
Sbjct: 286 DLTIKISDRGGGVPLRIIDRLFSYTYSTAPTPVMDNSRNAPLAG 329
>ref|NP_002602.2| pyruvate dehydrogenase kinase, isozyme 2 isoform 1 precursor [Homo
sapiens].
Length = 407
Score = 96.3 bits (238), Expect = 8e-20
Identities = 85/361 (23%), Positives = 149/361 (41%), Gaps = 18/361 (4%)
Frame = +3
Query: 537 SARYLQQELPVRIAHRIKDFRSLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADE- 713
S +L+QELPVR+A+ +K+ LP + P++ V Y+++ + +F KD D
Sbjct: 49 SFTFLRQELPVRLANIMKEINLLPDRVLSTPSVQLVQSWYVQSLLDIMEFLD-KDPEDHR 107
Query: 714 --AQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKL----VRSFLDKTLTSRLGIRM 875
+Q+ + + + H DVV +A+G+ E + D+ + ++ FLD+ SR+ IRM
Sbjct: 108 TLSQFTDALVTIRNRHNDVVPTMAQGVLEYKDTYGDDPVSNQNIQYFLDRFYLSRISIRM 167
Query: 876 LATHHLALHEDK-----PDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRI--- 1031
L H + + P +G I + ++++ D A+ LC+ Y +P + I
Sbjct: 168 LINQHTLIFDGSTNPAHPKHIGSIDPNCNVSEVVKDAYDMAKLLCDKYYMASPDLEIQEI 227
Query: 1032 ---NGHVAARFPFIPMPLDYILPELLKNAMRATMECHLDTPYNVPDVVITIANNGY*SRH 1202
N ++P L ++L EL KNAMRAT+E H ++ +P + + +A
Sbjct: 228 NAANSKQPIHMVYVPSHLYHMLFELFKNAMRATVESH-ESSLILPPIKVMVALG------ 280
Query: 1203 QDF*PGWGNCSQRPGSGYGLPLHHGRGQYPGPPDQPSLRPPRHAQWQPVRTHARVRPHLA 1382
+ S++ P+R R+ ++
Sbjct: 281 --------------------------------EEDLSIKMSDRGGGVPLRKIERLFSYMY 308
Query: 1383 GMEGWEAPGDSSL*GPCPVPLPIPSFGFGLPTSRAYAEYXXXXXXXXXXXXXXTDVYLQL 1562
PG P+ FG+GLP SR YA+Y TD + L
Sbjct: 309 STAPTPQPGTGG--------TPLAGFGYGLPISRLYAKYFQGDLQLFSMEGFGTDAVIYL 360
Query: 1563 R 1565
+
Sbjct: 361 K 361
>ref|NP_005382.1| pyruvate dehydrogenase kinase, isozyme 3 isoform 2 precursor [Homo
sapiens].
Length = 406
Score = 89.4 bits (220), Expect = 1e-17
Identities = 90/375 (24%), Positives = 155/375 (41%), Gaps = 23/375 (6%)
Frame = +3
Query: 537 SARYLQQELPVRIAHRIKDFRSLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEA 716
S +L++ELPVR+A+ +++ LP + P++ V Y+++F +L ++ + +
Sbjct: 45 SYMFLRKELPVRLANTMREVNLLPDNLLNRPSVGLVQSWYMQSFLELLEYENKSPEDPQV 104
Query: 717 --QYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRS----FLDKTLTSRLGIRML 878
+ Q++ ++ + H DVV +A+G+ E ++ + + + FLD+ T+R+ RML
Sbjct: 105 LDNFLQVLIKVRNRHNDVVPTMAQGVIEYKEKFGFDPFISTNIQYFLDRFYTNRISFRML 164
Query: 879 ATHHLAL-----HEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHV 1043
H L + P +G I + +++ + A+ LCE Y AP + +
Sbjct: 165 INQHTLLFGGDTNPVHPKHIGSIDPTCNVADVVKDAYETAKMLCEQYYLVAPELEVEEFN 224
Query: 1044 AA------RFPFIPMPLDYILPELLKNAMRATMECHLDTPYNVPDV--VITIANNGY*SR 1199
A + ++P L ++L EL KN+MRAT+E + D P V ++T+ +
Sbjct: 225 AKAPDKPIQVVYVPSHLFHMLFELFKNSMRATVELYEDRKEGYPAVKTLVTLGKEDLSIK 284
Query: 1200 HQDF*PGWGNCSQRPGSGYGLPLHH----GRGQYPGPPDQPSLRPPRHAQWQPVRTHARV 1367
D G G+PL Y P +PSL P R A
Sbjct: 285 ISDL-------------GGGVPLRKIDRLFNYMYSTAP-RPSLEPTRAA----------- 319
Query: 1368 RPHLAGMEGWEAPGDSSL*GPCPVPLPIPSFGFGLPTSRAYAEYXXXXXXXXXXXXXXTD 1547
P+ FG+GLP SR YA Y TD
Sbjct: 320 --------------------------PLAGFGYGLPISRLYARYFQGDLKLYSMEGVGTD 353
Query: 1548 VYLQLRHIDGREESF 1592
+ L+ + ESF
Sbjct: 354 AVIYLKALS--SESF 366
>ref|NP_001135858.1| pyruvate dehydrogenase kinase, isozyme 3 isoform 1 precursor [Homo
sapiens].
Length = 415
Score = 89.4 bits (220), Expect = 1e-17
Identities = 90/375 (24%), Positives = 155/375 (41%), Gaps = 23/375 (6%)
Frame = +3
Query: 537 SARYLQQELPVRIAHRIKDFRSLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEA 716
S +L++ELPVR+A+ +++ LP + P++ V Y+++F +L ++ + +
Sbjct: 45 SYMFLRKELPVRLANTMREVNLLPDNLLNRPSVGLVQSWYMQSFLELLEYENKSPEDPQV 104
Query: 717 --QYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRS----FLDKTLTSRLGIRML 878
+ Q++ ++ + H DVV +A+G+ E ++ + + + FLD+ T+R+ RML
Sbjct: 105 LDNFLQVLIKVRNRHNDVVPTMAQGVIEYKEKFGFDPFISTNIQYFLDRFYTNRISFRML 164
Query: 879 ATHHLAL-----HEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHV 1043
H L + P +G I + +++ + A+ LCE Y AP + +
Sbjct: 165 INQHTLLFGGDTNPVHPKHIGSIDPTCNVADVVKDAYETAKMLCEQYYLVAPELEVEEFN 224
Query: 1044 AA------RFPFIPMPLDYILPELLKNAMRATMECHLDTPYNVPDV--VITIANNGY*SR 1199
A + ++P L ++L EL KN+MRAT+E + D P V ++T+ +
Sbjct: 225 AKAPDKPIQVVYVPSHLFHMLFELFKNSMRATVELYEDRKEGYPAVKTLVTLGKEDLSIK 284
Query: 1200 HQDF*PGWGNCSQRPGSGYGLPLHH----GRGQYPGPPDQPSLRPPRHAQWQPVRTHARV 1367
D G G+PL Y P +PSL P R A
Sbjct: 285 ISDL-------------GGGVPLRKIDRLFNYMYSTAP-RPSLEPTRAA----------- 319
Query: 1368 RPHLAGMEGWEAPGDSSL*GPCPVPLPIPSFGFGLPTSRAYAEYXXXXXXXXXXXXXXTD 1547
P+ FG+GLP SR YA Y TD
Sbjct: 320 --------------------------PLAGFGYGLPISRLYARYFQGDLKLYSMEGVGTD 353
Query: 1548 VYLQLRHIDGREESF 1592
+ L+ + ESF
Sbjct: 354 AVIYLKALS--SESF 366
>ref|NP_001186828.1| pyruvate dehydrogenase kinase, isozyme 2 isoform 2 [Homo sapiens].
Length = 343
Score = 79.7 bits (195), Expect = 8e-15
Identities = 76/345 (22%), Positives = 136/345 (39%), Gaps = 18/345 (5%)
Frame = +3
Query: 585 IKDFRSLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADE---AQYCQLVRQLLDDH 755
+K+ LP + P++ V Y+++ + +F KD D +Q+ + + + H
Sbjct: 1 MKEINLLPDRVLSTPSVQLVQSWYVQSLLDIMEFLD-KDPEDHRTLSQFTDALVTIRNRH 59
Query: 756 KDVVTLLAEGLRESRKHIEDEKL----VRSFLDKTLTSRLGIRMLATHHLALHEDK---- 911
DVV +A+G+ E + D+ + ++ FLD+ SR+ IRML H + +
Sbjct: 60 NDVVPTMAQGVLEYKDTYGDDPVSNQNIQYFLDRFYLSRISIRMLINQHTLIFDGSTNPA 119
Query: 912 -PDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRI------NGHVAARFPFIPM 1070
P +G I + ++++ D A+ LC+ Y +P + I N ++P
Sbjct: 120 HPKHIGSIDPNCNVSEVVKDAYDMAKLLCDKYYMASPDLEIQEINAANSKQPIHMVYVPS 179
Query: 1071 PLDYILPELLKNAMRATMECHLDTPYNVPDVVITIANNGY*SRHQDF*PGWGNCSQRPGS 1250
L ++L EL KNAMRAT+E H ++ +P + + +A
Sbjct: 180 HLYHMLFELFKNAMRATVESH-ESSLILPPIKVMVALG---------------------- 216
Query: 1251 GYGLPLHHGRGQYPGPPDQPSLRPPRHAQWQPVRTHARVRPHLAGMEGWEAPGDSSL*GP 1430
+ S++ P+R R+ ++ PG
Sbjct: 217 ----------------EEDLSIKMSDRGGGVPLRKIERLFSYMYSTAPTPQPGTGG---- 256
Query: 1431 CPVPLPIPSFGFGLPTSRAYAEYXXXXXXXXXXXXXXTDVYLQLR 1565
P+ FG+GLP SR YA+Y TD + L+
Sbjct: 257 ----TPLAGFGYGLPISRLYAKYFQGDLQLFSMEGFGTDAVIYLK 297
>ref|NP_001186827.1| pyruvate dehydrogenase kinase, isozyme 2 isoform 2 [Homo sapiens].
Length = 343
Score = 79.7 bits (195), Expect = 8e-15
Identities = 76/345 (22%), Positives = 136/345 (39%), Gaps = 18/345 (5%)
Frame = +3
Query: 585 IKDFRSLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADE---AQYCQLVRQLLDDH 755
+K+ LP + P++ V Y+++ + +F KD D +Q+ + + + H
Sbjct: 1 MKEINLLPDRVLSTPSVQLVQSWYVQSLLDIMEFLD-KDPEDHRTLSQFTDALVTIRNRH 59
Query: 756 KDVVTLLAEGLRESRKHIEDEKL----VRSFLDKTLTSRLGIRMLATHHLALHEDK---- 911
DVV +A+G+ E + D+ + ++ FLD+ SR+ IRML H + +
Sbjct: 60 NDVVPTMAQGVLEYKDTYGDDPVSNQNIQYFLDRFYLSRISIRMLINQHTLIFDGSTNPA 119
Query: 912 -PDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRI------NGHVAARFPFIPM 1070
P +G I + ++++ D A+ LC+ Y +P + I N ++P
Sbjct: 120 HPKHIGSIDPNCNVSEVVKDAYDMAKLLCDKYYMASPDLEIQEINAANSKQPIHMVYVPS 179
Query: 1071 PLDYILPELLKNAMRATMECHLDTPYNVPDVVITIANNGY*SRHQDF*PGWGNCSQRPGS 1250
L ++L EL KNAMRAT+E H ++ +P + + +A
Sbjct: 180 HLYHMLFELFKNAMRATVESH-ESSLILPPIKVMVALG---------------------- 216
Query: 1251 GYGLPLHHGRGQYPGPPDQPSLRPPRHAQWQPVRTHARVRPHLAGMEGWEAPGDSSL*GP 1430
+ S++ P+R R+ ++ PG
Sbjct: 217 ----------------EEDLSIKMSDRGGGVPLRKIERLFSYMYSTAPTPQPGTGG---- 256
Query: 1431 CPVPLPIPSFGFGLPTSRAYAEYXXXXXXXXXXXXXXTDVYLQLR 1565
P+ FG+GLP SR YA+Y TD + L+
Sbjct: 257 ----TPLAGFGYGLPISRLYAKYFQGDLQLFSMEGFGTDAVIYLK 297
>ref|NP_001186829.1| pyruvate dehydrogenase kinase, isozyme 2 isoform 3 precursor [Homo
sapiens].
Length = 199
Score = 59.7 bits (143), Expect = 9e-09
Identities = 38/125 (30%), Positives = 67/125 (53%), Gaps = 7/125 (5%)
Frame = +3
Query: 537 SARYLQQELPVRIAHRIKDFRSLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADE- 713
S +L+QELPVR+A+ +K+ LP + P++ V Y+++ + +F KD D
Sbjct: 49 SFTFLRQELPVRLANIMKEINLLPDRVLSTPSVQLVQSWYVQSLLDIMEFLD-KDPEDHR 107
Query: 714 --AQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKL----VRSFLDKTLTSRLGIRM 875
+Q+ + + + H DVV +A+G+ E + D+ + ++ FLD+ SR+ IRM
Sbjct: 108 TLSQFTDALVTIRNRHNDVVPTMAQGVLEYKDTYGDDPVSNQNIQYFLDRFYLSRISIRM 167
Query: 876 LATHH 890
L H
Sbjct: 168 LINQH 172
Database: RefSeq49_HP.fasta
Posted date: Oct 17, 2011 1:42 PM
Number of letters in database: 18,297,164
Number of sequences in database: 32,964
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 32964
Number of Hits to DB: 83,278,704
Number of extensions: 2779521
Number of successful extensions: 15341
Number of sequences better than 1.0e-05: 10
Number of HSP's gapped: 15160
Number of HSP's successfully gapped: 21
Length of query: 601
Length of database: 18,297,164
Length adjustment: 108
Effective length of query: 493
Effective length of database: 14,737,052
Effective search space: 7265366636
Effective search space used: 7265366636
Neighboring words threshold: 12
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 36 (18.5 bits)
Search to Sscrofa10_2
BLASTN 2.2.24 [Aug-08-2010]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= 20110601C-008065
(1804 letters)
Database: Sscrofa_10.2.fasta
4582 sequences; 2,808,509,378 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
Sscrofa_Chr03 1178 0.0
>Sscrofa_Chr03
|| Length = 144787322
Score = 1178 bits (594), Expect = 0.0
Identities = 600/602 (99%)
Strand = Plus / Plus
Query: 1203 caggatttctgaccggggtgggggaattgctcacaaagacctggatcgggttatggacta 1262
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 17495959 caggatttctgaccggggtgggggaattgctcacaaagacctggatcgggttatggacta 17496018
Query: 1263 ccacttcaccacggccgaggccagtacccaggacccccggatcagccctctcttcggcca 1322
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 17496019 ccacttcaccacggccgaggccagtacccaggacccccggatcagccctctcttcggcca 17496078
Query: 1323 cctagacatgcacagtggcagccagtcaggacccatgcacgggtgaggccccacctggct 1382
||||||||||||||||||||||||||| ||||||||||||||||||||||||||||||||
Sbjct: 17496079 cctagacatgcacagtggcagccagtcgggacccatgcacgggtgaggccccacctggct 17496138
Query: 1383 ggaatggaggggtgggaggccccaggagactcaagcctctgaggcccgtgtcctgtcccc 1442
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 17496139 ggaatggaggggtgggaggccccaggagactcaagcctctgaggcccgtgtcctgtcccc 17496198
Query: 1443 ctgcccatccccagctttggcttcgggctgcccacgtcgcgggcttatgcagaatacctc 1502
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 17496199 ctgcccatccccagctttggcttcgggctgcccacgtcgcgggcttatgcagaatacctc 17496258
Query: 1503 ggtggttcccttcggctgcagtccctgcagggcatcggcacggatgtctacctgcagctt 1562
||||||||||||||||||||||||||||||||||||||||||||||||||||||| ||||
Sbjct: 17496259 ggtggttcccttcggctgcagtccctgcagggcatcggcacggatgtctacctgcggctt 17496318
Query: 1563 cggcacatcgatggccgggaggaaagcttccgcatctgaccccacagctctgggcctgcg 1622
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 17496319 cggcacatcgatggccgggaggaaagcttccgcatctgaccccacagctctgggcctgcg 17496378
Query: 1623 gacctgcccaggttgggccacacaccctgccaggaccttccaggccaggccgggtgccac 1682
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 17496379 gacctgcccaggttgggccacacaccctgccaggaccttccaggccaggccgggtgccac 17496438
Query: 1683 cctgctccacacactgctgtgtctctcgggctgaagggccccaaacagatggacttacat 1742
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 17496439 cctgctccacacactgctgtgtctctcgggctgaagggccccaaacagatggacttacat 17496498
Query: 1743 ggagccaggcgccgcccctcctcgatagggtccactgcttccctgcctccaggccttaga 1802
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 17496499 ggagccaggcgccgcccctcctcgatagggtccactgcttccctgcctccaggccttaga 17496558
Query: 1803 gc 1804
||
Sbjct: 17496559 gc 17496560
Score = 680 bits (343), Expect = 0.0
Identities = 362/371 (97%)
Strand = Plus / Plus
Query: 94 agatgggagctgctccctgggggctgagcttgtcagcatcctggactggccctcgcccct 153
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 17492119 agatgggagctgctccctgggggctgagcttgtcagcatcctggactggccctcgcccct 17492178
Query: 154 gaagtcaagagaagagtccctgcgcacccacacctctctagctcccttttggggtcgctt 213
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 17492179 gaagtcaagagaagagtccctgcgcacccacacctctctagctcccttttggggtcgctt 17492238
Query: 214 cagtctgtcgggtcttcagccctagtggctgcgcagtccgacaaaggagcagaacgatga 273
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 17492239 cagtctgtcgggtcttcagccctagtggctgcgcagtccgacaaaggagcagaacgatga 17492298
Query: 274 tgctggcatcggtgctggggagtggtccccnnnnnnnnccaccactccggcctctcttgg 333
|||||||||||||||||||||||||||||| ||||||||||||||||||||||
Sbjct: 17492299 tgctggcatcggtgctggggagtggtccccggggggggccaccactccggcctctcttgg 17492358
Query: 334 ggcccgcactctcgctccgggccctctccacatcagccaccgatacccaccacgtggaga 393
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 17492359 ggcccgcactctcgctccgggccctctccacatcagccaccgatacccaccacgtggaga 17492418
Query: 394 tggcgcgggagcgctccaagaccgtcacctccttttacaaccagtcagccatcgacgcag 453
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 17492419 tggcgcgggagcgctccaagaccgtcacctccttttacaaccagtcagccatcgacgcag 17492478
Query: 454 cagcggagaag 464
|||| ||||||
Sbjct: 17492479 cagcagagaag 17492489
Score = 262 bits (132), Expect = 6e-67
Identities = 132/132 (100%)
Strand = Plus / Plus
Query: 983 cagacgcctgtgtgagcacaagtatggcaacgccccccgggtccgcatcaacggccacgt 1042
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 17494494 cagacgcctgtgtgagcacaagtatggcaacgccccccgggtccgcatcaacggccacgt 17494553
Query: 1043 ggctgcccgtttccccttcatccccatgccgctggactacatcctgcccgagctgctcaa 1102
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 17494554 ggctgcccgtttccccttcatccccatgccgctggactacatcctgcccgagctgctcaa 17494613
Query: 1103 gaatgccatgag 1114
||||||||||||
Sbjct: 17494614 gaatgccatgag 17494625
Score = 242 bits (122), Expect = 6e-61
Identities = 122/122 (100%)
Strand = Plus / Plus
Query: 692 gatcaaggaccaggcggatgaggcccagtactgccagctggtgcgacagctgttggacga 751
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 17493325 gatcaaggaccaggcggatgaggcccagtactgccagctggtgcgacagctgttggacga 17493384
Query: 752 ccacaaggatgtggtgaccctcttggctgagggcctgcgtgagagccggaagcacataga 811
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 17493385 ccacaaggatgtggtgaccctcttggctgagggcctgcgtgagagccggaagcacataga 17493444
Query: 812 gg 813
||
Sbjct: 17493445 gg 17493446
Score = 222 bits (112), Expect = 5e-55
Identities = 112/112 (100%)
Strand = Plus / Plus
Query: 533 gaaaagtgctcggtacttgcagcaagagttgcccgtgaggattgctcaccgcatcaagga 592
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 17492779 gaaaagtgctcggtacttgcagcaagagttgcccgtgaggattgctcaccgcatcaagga 17492838
Query: 593 cttccgcagccttcctttcatcattggctgcaaccccactatactgcacgtg 644
||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 17492839 cttccgcagccttcctttcatcattggctgcaaccccactatactgcacgtg 17492890
Score = 200 bits (101), Expect = 2e-48
Identities = 101/101 (100%)
Strand = Plus / Plus
Query: 811 aggacgagaagctggtccgctccttcttagacaagacgctgacttcgaggctcgggatcc 870
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 17493527 aggacgagaagctggtccgctccttcttagacaagacgctgacttcgaggctcgggatcc 17493586
Query: 871 gcatgttggccacacaccatctggctctacatgaggacaag 911
|||||||||||||||||||||||||||||||||||||||||
Sbjct: 17493587 gcatgttggccacacaccatctggctctacatgaggacaag 17493627
Score = 188 bits (95), Expect = 7e-45
Identities = 95/95 (100%)
Strand = Plus / Plus
Query: 1 atcccggcggcagagggcgcaggcggctcggctaatccggcgggtcgactgtcgggccgt 60
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 17491395 atcccggcggcagagggcgcaggcggctcggctaatccggcgggtcgactgtcgggccgt 17491454
Query: 61 cccgctcggaccccggccctagctctggccccgag 95
|||||||||||||||||||||||||||||||||||
Sbjct: 17491455 cccgctcggaccccggccctagctctggccccgag 17491489
Score = 170 bits (86), Expect = 2e-39
Identities = 93/94 (98%), Gaps = 1/94 (1%)
Strand = Plus / Plus
Query: 1113 agagccacgatggaatgtcacctagacacgccctacaacgtcccggatgtggtcatcacc 1172
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 17494712 agagccacgatggaatgtcacctagacacgccctacaacgtcccggatgtggtcatcacc 17494771
Query: 1173 atcgccaacaacggatattgatctcgtcatcagg 1206
|||||||||||| |||||||||||||||||||||
Sbjct: 17494772 atcgccaacaac-gatattgatctcgtcatcagg 17494804
Score = 151 bits (76), Expect = 2e-33
Identities = 76/76 (100%)
Strand = Plus / Plus
Query: 910 agcccgactttgttggcatcatctgcactcgcctctcaccaaagaagattattgaaaaat 969
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 17493830 agcccgactttgttggcatcatctgcactcgcctctcaccaaagaagattattgaaaaat 17493889
Query: 970 gggtggactttgccag 985
||||||||||||||||
Sbjct: 17493890 gggtggactttgccag 17493905
Score = 141 bits (71), Expect = 2e-30
Identities = 71/71 (100%)
Strand = Plus / Plus
Query: 463 agccctcagtccgcctcactccgaccatgatgctctattcaggacgctctcaggatggca 522
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 17492616 agccctcagtccgcctcactccgaccatgatgctctattcaggacgctctcaggatggca 17492675
Query: 523 gccacctgctg 533
|||||||||||
Sbjct: 17492676 gccacctgctg 17492686
Score = 97.6 bits (49), Expect = 2e-17
Identities = 49/49 (100%)
Strand = Plus / Plus
Query: 644 gcacgaactgtacatccgtgccttccagaagctgacagacttccctccg 692
|||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 17493193 gcacgaactgtacatccgtgccttccagaagctgacagacttccctccg 17493241
Database: Sscrofa_10.2.fasta
Posted date: Nov 16, 2011 10:34 AM
Number of letters in database: 2,808,509,378
Number of sequences in database: 4582
Lambda K H
1.37 0.711 1.31
Gapped
Lambda K H
1.37 0.711 1.31
Matrix: blastn matrix:1 -3
Gap Penalties: Existence: 5, Extension: 2
Number of Sequences: 4582
Number of Hits to DB: 40,465,431
Number of extensions: 236
Number of successful extensions: 236
Number of sequences better than 1.0e-05: 1
Number of HSP's gapped: 235
Number of HSP's successfully gapped: 12
Length of query: 1804
Length of database: 2,808,509,378
Length adjustment: 22
Effective length of query: 1782
Effective length of database: 2,808,408,574
Effective search space: 5004584078868
Effective search space used: 5004584078868
X1: 11 (21.8 bits)
X2: 15 (29.7 bits)
X3: 50 (99.1 bits)
S1: 18 (36.2 bits)
S2: 30 (60.0 bits)