Search to RefSeqBP
BLASTX 2.2.10 [Oct-19-2004]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= LVRM1_0096_C03
(1457 letters)
Database: RefSeqBP
33,508 sequences; 16,112,626 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
Alignment gi|NP_001030472.1| hypothetical protein LOC533086 [Bos taurus] 530 e-150
Alignment gi|XP_879080.1| PREDICTED: similar to microsomal NAD+-dependent... 384 e-106
Alignment gi|XP_878888.1| PREDICTED: similar to microsomal NAD+-dependent... 384 e-106
Alignment gi|XP_878794.1| PREDICTED: similar to microsomal NAD+-dependent... 384 e-106
Alignment gi|XP_869667.1| PREDICTED: similar to microsomal NAD+-dependent... 384 e-106
Alignment gi|XP_878985.1| PREDICTED: similar to microsomal NAD+-dependent... 379 e-105
Alignment gi|XP_601132.2| PREDICTED: similar to microsomal NAD+-dependent... 370 e-102
Alignment gi|XP_583421.2| PREDICTED: similar to orphan short-chain dehydr... 327 1e-89
Alignment gi|NP_777158.1| NADP-dependent retinol dehydrogenase/reductase ... 305 6e-83
Alignment gi|NP_776591.1| retinol dehydrogenase 5 (11-cis and 9-cis) [Bos... 275 5e-74
>ref|NP_001030472.1| hypothetical protein LOC533086 [Bos taurus]
Length = 317
Score = 530 bits (1365), Expect = e-150
Identities = 259/317 (81%), Positives = 279/317 (88%)
Frame = +1
Query: 121 MWXXXXXXXXXXXXXRWYRERQMVSHLGDKYVFIAGCDSGFGNLLARQLDVRGLRVLAAC 300
MW RW+RERQ+VSHL DK+VFI GCDSGFGN LARQLD+RGLRVLA C
Sbjct: 1 MWLYLAVLLGLYYLLRWFRERQVVSHLQDKFVFITGCDSGFGNQLARQLDLRGLRVLAGC 60
Query: 301 LTEQGAQQLRKQTSDRLETVLLDVTKTESIAAATQWVKERVGDRGLWGLVNNAGTFHPLC 480
LTEQGA+QLR QTSDRL+TV+LDVTKTESIAAAT+WVKE VGDRGLWGLVNNAG FH
Sbjct: 61 LTEQGAEQLRNQTSDRLQTVILDVTKTESIAAATEWVKECVGDRGLWGLVNNAGIFHSHG 120
Query: 481 ITEWLKTETWIHTLKVNLIGVTEVTLSMLPLVKKAQGRIVNVSSILGRVAFFGAVYSSSK 660
EW+K ET+ TL+VNLIGV EVTLSMLPLV+KAQGRIVNVSSILGR+AFFGAVYS SK
Sbjct: 121 YAEWIKIETYRDTLRVNLIGVIEVTLSMLPLVRKAQGRIVNVSSILGRIAFFGAVYSCSK 180
Query: 661 HGVEAFSDVLRCELQHFGVKVSIVEPGYFRTGMTDVQKSSEAMKQVWKEVPAHIKDTYGQ 840
+GVEAFSD+LR ELQHFGVKVS+VEPGYFRT MTD QK SE MKQ+WKE PAHIK+TYGQ
Sbjct: 181 YGVEAFSDILRRELQHFGVKVSMVEPGYFRTAMTDWQKFSEIMKQIWKETPAHIKETYGQ 240
Query: 841 KFFDAYHDVMKQGLSSCSTNLNLVTDCMEHALTSVHPRTRYSAGWDAQFFFIPLSYLPTS 1020
KFFDAYHD+MKQGL SCSTNLNLVTDCMEHALTSVHPRTRYSAGWDAQFFF+PLSYLPTS
Sbjct: 241 KFFDAYHDLMKQGLLSCSTNLNLVTDCMEHALTSVHPRTRYSAGWDAQFFFVPLSYLPTS 300
Query: 1021 LADYILTRSWPKPVQAV 1071
LADYILTRSWPKP QAV
Sbjct: 301 LADYILTRSWPKPAQAV 317
>ref|XP_879080.1| PREDICTED: similar to microsomal NAD+-dependent retinol dehydrogenase
4 isoform 5 [Bos taurus]
Length = 317
Score = 384 bits (986), Expect = e-106
Identities = 191/318 (60%), Positives = 239/318 (75%), Gaps = 1/318 (0%)
Frame = +1
Query: 121 MWXXXXXXXXXXXXXRWYRERQMVSHLGDKYVFIAGCDSGFGNLLARQLDVRGLRVLAAC 300
MW RWYRERQ+VSHL DK+VFI GCDSGFGNLLARQLD+RGLRVLAAC
Sbjct: 1 MWLYLVVLVGLYYLLRWYRERQVVSHLRDKFVFITGCDSGFGNLLARQLDLRGLRVLAAC 60
Query: 301 LTEQGAQQLRKQTSDRLETVLLDVTKTESIAAATQWVKERVGDRGLWGLVNNAGTFHPLC 480
LTE+GA+QLR QTSDRL+TV+LDVTKT+S+AAAT+WVKERVGDRGLWGLVNNAG P
Sbjct: 61 LTEKGAEQLRNQTSDRLQTVILDVTKTDSVAAATEWVKERVGDRGLWGLVNNAGISTPTA 120
Query: 481 ITEWLKTETWIHTLKVNLIGVTEVTLSMLPLVKKAQGRIVNVSSILGRVAFFGAVYSSSK 660
EWL + ++ L VNL+GV +VTLS+LPLV+KA+GR+VNVSSI+GRVA G Y SK
Sbjct: 121 PNEWLTKQDFMKILDVNLLGVIDVTLSVLPLVRKARGRVVNVSSIMGRVALLGGGYCMSK 180
Query: 661 HGVEAFSDVLRCELQHFGVKVSIVEPGYFRTGMTDVQKSSEAMKQVWKEVPAHIKDTYGQ 840
+GVEAFSD LR EL +FGVKV ++EPGYF+T +T + S+ + W + IK+ YG+
Sbjct: 181 YGVEAFSDSLRRELSYFGVKVVMIEPGYFKTAVTSPKALSQGFQASWNQASPEIKELYGE 240
Query: 841 KFF-DAYHDVMKQGLSSCSTNLNLVTDCMEHALTSVHPRTRYSAGWDAQFFFIPLSYLPT 1017
KF + V +SC +L+LVT+CMEHALT+ HPRTRYS GWDA+F ++P+SYLP+
Sbjct: 241 KFMANLMKSVDLLETTSCQ-DLSLVTNCMEHALTACHPRTRYSPGWDAKFIYLPMSYLPS 299
Query: 1018 SLADYILTRSWPKPVQAV 1071
L D ++ P+P +A+
Sbjct: 300 FLVDLMVYWRNPRPAKAL 317
>ref|XP_878888.1| PREDICTED: similar to microsomal NAD+-dependent retinol dehydrogenase
4 isoform 3 [Bos taurus]
Length = 317
Score = 384 bits (986), Expect = e-106
Identities = 191/318 (60%), Positives = 239/318 (75%), Gaps = 1/318 (0%)
Frame = +1
Query: 121 MWXXXXXXXXXXXXXRWYRERQMVSHLGDKYVFIAGCDSGFGNLLARQLDVRGLRVLAAC 300
MW RWYRERQ+VSHL DK+VFI GCDSGFGNLLARQLD+RGLRVLAAC
Sbjct: 1 MWLYLVVLVGLYYLLRWYRERQVVSHLRDKFVFITGCDSGFGNLLARQLDLRGLRVLAAC 60
Query: 301 LTEQGAQQLRKQTSDRLETVLLDVTKTESIAAATQWVKERVGDRGLWGLVNNAGTFHPLC 480
LTE+GA+QLR QTSDRL+TV+LDVTKT+S+AAAT+WVKERVGDRGLWGLVNNAG P
Sbjct: 61 LTEKGAEQLRNQTSDRLQTVILDVTKTDSVAAATEWVKERVGDRGLWGLVNNAGISTPTA 120
Query: 481 ITEWLKTETWIHTLKVNLIGVTEVTLSMLPLVKKAQGRIVNVSSILGRVAFFGAVYSSSK 660
EWL + ++ L VNL+GV +VTLS+LPLV+KA+GR+VNVSSI+GRVA G Y SK
Sbjct: 121 PNEWLTKQDFMKILDVNLLGVIDVTLSVLPLVRKARGRVVNVSSIMGRVALLGGGYCMSK 180
Query: 661 HGVEAFSDVLRCELQHFGVKVSIVEPGYFRTGMTDVQKSSEAMKQVWKEVPAHIKDTYGQ 840
+GVEAFSD LR EL +FGVKV ++EPGYF+T +T + S+ + W + IK+ YG+
Sbjct: 181 YGVEAFSDSLRRELSYFGVKVVMIEPGYFKTAVTSPKALSQGFQASWNQASPEIKELYGE 240
Query: 841 KFF-DAYHDVMKQGLSSCSTNLNLVTDCMEHALTSVHPRTRYSAGWDAQFFFIPLSYLPT 1017
KF + V +SC +L+LVT+CMEHALT+ HPRTRYS GWDA+F ++P+SYLP+
Sbjct: 241 KFMANLMKSVDLLETTSCQ-DLSLVTNCMEHALTACHPRTRYSPGWDAKFIYLPMSYLPS 299
Query: 1018 SLADYILTRSWPKPVQAV 1071
L D ++ P+P +A+
Sbjct: 300 FLVDLMVYWRNPRPAKAL 317
>ref|XP_878794.1| PREDICTED: similar to microsomal NAD+-dependent retinol dehydrogenase
4 isoform 2 [Bos taurus]
Length = 317
Score = 384 bits (986), Expect = e-106
Identities = 191/318 (60%), Positives = 239/318 (75%), Gaps = 1/318 (0%)
Frame = +1
Query: 121 MWXXXXXXXXXXXXXRWYRERQMVSHLGDKYVFIAGCDSGFGNLLARQLDVRGLRVLAAC 300
MW RWYRERQ+VSHL DK+VFI GCDSGFGNLLARQLD+RGLRVLAAC
Sbjct: 1 MWLYLVVLVGLYYLLRWYRERQVVSHLRDKFVFITGCDSGFGNLLARQLDLRGLRVLAAC 60
Query: 301 LTEQGAQQLRKQTSDRLETVLLDVTKTESIAAATQWVKERVGDRGLWGLVNNAGTFHPLC 480
LTE+GA+QLR QTSDRL+TV+LDVTKT+S+AAAT+WVKERVGDRGLWGLVNNAG P
Sbjct: 61 LTEKGAEQLRNQTSDRLQTVILDVTKTDSVAAATEWVKERVGDRGLWGLVNNAGISTPTA 120
Query: 481 ITEWLKTETWIHTLKVNLIGVTEVTLSMLPLVKKAQGRIVNVSSILGRVAFFGAVYSSSK 660
EWL + ++ L VNL+GV +VTLS+LPLV+KA+GR+VNVSSI+GRVA G Y SK
Sbjct: 121 PNEWLTKQDFMKILDVNLLGVIDVTLSVLPLVRKARGRVVNVSSIMGRVALLGGGYCMSK 180
Query: 661 HGVEAFSDVLRCELQHFGVKVSIVEPGYFRTGMTDVQKSSEAMKQVWKEVPAHIKDTYGQ 840
+GVEAFSD LR EL +FGVKV ++EPGYF+T +T + S+ + W + IK+ YG+
Sbjct: 181 YGVEAFSDSLRRELSYFGVKVVMIEPGYFKTAVTSPKALSQGFQASWNQASPEIKELYGE 240
Query: 841 KFF-DAYHDVMKQGLSSCSTNLNLVTDCMEHALTSVHPRTRYSAGWDAQFFFIPLSYLPT 1017
KF + V +SC +L+LVT+CMEHALT+ HPRTRYS GWDA+F ++P+SYLP+
Sbjct: 241 KFMANLMKSVDLLETTSCQ-DLSLVTNCMEHALTACHPRTRYSPGWDAKFIYLPMSYLPS 299
Query: 1018 SLADYILTRSWPKPVQAV 1071
L D ++ P+P +A+
Sbjct: 300 FLVDLMVYWRNPRPAKAL 317
>ref|XP_869667.1| PREDICTED: similar to microsomal NAD+-dependent retinol dehydrogenase
4 isoform 1 [Bos taurus]
Length = 317
Score = 384 bits (986), Expect = e-106
Identities = 191/318 (60%), Positives = 239/318 (75%), Gaps = 1/318 (0%)
Frame = +1
Query: 121 MWXXXXXXXXXXXXXRWYRERQMVSHLGDKYVFIAGCDSGFGNLLARQLDVRGLRVLAAC 300
MW RWYRERQ+VSHL DK+VFI GCDSGFGNLLARQLD+RGLRVLAAC
Sbjct: 1 MWLYLVVLVGLYYLLRWYRERQVVSHLRDKFVFITGCDSGFGNLLARQLDLRGLRVLAAC 60
Query: 301 LTEQGAQQLRKQTSDRLETVLLDVTKTESIAAATQWVKERVGDRGLWGLVNNAGTFHPLC 480
LTE+GA+QLR QTSDRL+TV+LDVTKT+S+AAAT+WVKERVGDRGLWGLVNNAG P
Sbjct: 61 LTEKGAEQLRNQTSDRLQTVILDVTKTDSVAAATEWVKERVGDRGLWGLVNNAGISTPTA 120
Query: 481 ITEWLKTETWIHTLKVNLIGVTEVTLSMLPLVKKAQGRIVNVSSILGRVAFFGAVYSSSK 660
EWL + ++ L VNL+GV +VTLS+LPLV+KA+GR+VNVSSI+GRVA G Y SK
Sbjct: 121 PNEWLTKQDFMKILDVNLLGVIDVTLSVLPLVRKARGRVVNVSSIMGRVALLGGGYCMSK 180
Query: 661 HGVEAFSDVLRCELQHFGVKVSIVEPGYFRTGMTDVQKSSEAMKQVWKEVPAHIKDTYGQ 840
+GVEAFSD LR EL +FGVKV ++EPGYF+T +T + S+ + W + IK+ YG+
Sbjct: 181 YGVEAFSDSLRRELSYFGVKVVMIEPGYFKTAVTSPKALSQGFQASWNQASPEIKELYGE 240
Query: 841 KFF-DAYHDVMKQGLSSCSTNLNLVTDCMEHALTSVHPRTRYSAGWDAQFFFIPLSYLPT 1017
KF + V +SC +L+LVT+CMEHALT+ HPRTRYS GWDA+F ++P+SYLP+
Sbjct: 241 KFMANLMKSVDLLETTSCQ-DLSLVTNCMEHALTACHPRTRYSPGWDAKFIYLPMSYLPS 299
Query: 1018 SLADYILTRSWPKPVQAV 1071
L D ++ P+P +A+
Sbjct: 300 FLVDLMVYWRNPRPAKAL 317
>ref|XP_878985.1| PREDICTED: similar to microsomal NAD+-dependent retinol dehydrogenase
4 isoform 4 [Bos taurus]
Length = 317
Score = 379 bits (973), Expect = e-105
Identities = 187/317 (58%), Positives = 235/317 (74%)
Frame = +1
Query: 121 MWXXXXXXXXXXXXXRWYRERQMVSHLGDKYVFIAGCDSGFGNLLARQLDVRGLRVLAAC 300
MW RWYRERQ+VSHL DK+VFI GCDSGFGNLLARQLD+RGLRVLAAC
Sbjct: 1 MWLYLVVLVGLYYLLRWYRERQVVSHLRDKFVFITGCDSGFGNLLARQLDLRGLRVLAAC 60
Query: 301 LTEQGAQQLRKQTSDRLETVLLDVTKTESIAAATQWVKERVGDRGLWGLVNNAGTFHPLC 480
LTE+GA+QLR QTSDRL+TV+LDVTKT+S+AAAT+WVKERVGDRGLWGLVNNAG P
Sbjct: 61 LTEKGAEQLRNQTSDRLQTVILDVTKTDSVAAATEWVKERVGDRGLWGLVNNAGISTPTA 120
Query: 481 ITEWLKTETWIHTLKVNLIGVTEVTLSMLPLVKKAQGRIVNVSSILGRVAFFGAVYSSSK 660
EWL + ++ L VNL+GV +VTLS+LPLV+KA+GR+VNVSSI+GRVA G Y SK
Sbjct: 121 PNEWLTKQDFMKILDVNLLGVIDVTLSVLPLVRKARGRVVNVSSIMGRVALLGGGYCMSK 180
Query: 661 HGVEAFSDVLRCELQHFGVKVSIVEPGYFRTGMTDVQKSSEAMKQVWKEVPAHIKDTYGQ 840
+GVEAFSD LR EL +FGVKV ++EPGYF+T +T + S+ + W + IK+ YG+
Sbjct: 181 YGVEAFSDSLRRELSYFGVKVVMIEPGYFKTAVTSPKALSQGFQASWNQASPEIKELYGE 240
Query: 841 KFFDAYHDVMKQGLSSCSTNLNLVTDCMEHALTSVHPRTRYSAGWDAQFFFIPLSYLPTS 1020
+ + S +L+LVT+CMEHALT+ HPRTRYS GWDA+F ++P+SYLP+
Sbjct: 241 NHGKLALEQLIFTSSDLLFDLSLVTNCMEHALTACHPRTRYSPGWDAKFIYLPMSYLPSF 300
Query: 1021 LADYILTRSWPKPVQAV 1071
L D ++ P+P +A+
Sbjct: 301 LVDLMVYWRNPRPAKAL 317
>ref|XP_601132.2| PREDICTED: similar to microsomal NAD+-dependent retinol dehydrogenase
4 [Bos taurus]
Length = 338
Score = 370 bits (951), Expect = e-102
Identities = 184/338 (54%), Positives = 238/338 (70%), Gaps = 21/338 (6%)
Frame = +1
Query: 121 MWXXXXXXXXXXXXXRWYRERQMVSHLGDKYVFIAGCDSGFGNLLARQLDVRGLRVLAAC 300
MW RWYRERQ+VSHL DK+VFI GCDSGFGN LARQLD++GLRVLAAC
Sbjct: 1 MWLYLAVLLGLYYFLRWYRERQVVSHLRDKFVFITGCDSGFGNQLARQLDLKGLRVLAAC 60
Query: 301 LTEQGAQQLRKQTSDRLETVLLDVTKTESIAAATQWVKERVGDRGLWGLVNNAGTFHPLC 480
L +QGA+QLR QTSDRL+TV+LDVTKTES+AAAT+WVKERVGDRGLWGLVNNAG P+
Sbjct: 61 LMKQGAEQLRNQTSDRLQTVILDVTKTESVAAATEWVKERVGDRGLWGLVNNAGICTPMA 120
Query: 481 ITEWLKTETWIHTLKVNLIGVTEVTLSMLPLVKKAQGRIVNVSSILGRVAFFGAVYSSSK 660
+WL + ++ L+VNL+GV +VTLS+LPLV+KA+G +VNVSS++GR+A FG YS SK
Sbjct: 121 PNQWLTKQDFVKILEVNLLGVIDVTLSLLPLVRKARGHVVNVSSVMGRMAVFGGGYSMSK 180
Query: 661 HGVEAFSDVL---------------------RCELQHFGVKVSIVEPGYFRTGMTDVQKS 777
+GVEAFSD L R EL +FGVKV+++EPGYF T MT +
Sbjct: 181 YGVEAFSDSLSSSHLLCMSFDGKHVHVFGIPRRELSYFGVKVAVIEPGYFLTDMTQEEVY 240
Query: 778 SEAMKQVWKEVPAHIKDTYGQKFFDAYHDVMKQGLSSCSTNLNLVTDCMEHALTSVHPRT 957
E ++ W I++ YG F + + + NL+LVT+CMEHALT+ HPR+
Sbjct: 241 HENLQTSWDHASPEIQELYGDNFLADFIKASDFLKAPWARNLSLVTNCMEHALTACHPRS 300
Query: 958 RYSAGWDAQFFFIPLSYLPTSLADYILTRSWPKPVQAV 1071
RYSAGWDA+F ++P+SYLP+ L D ++ ++P+P +A+
Sbjct: 301 RYSAGWDAKFLYLPMSYLPSFLVDLMIYWNYPQPAKAL 338
>ref|XP_583421.2| PREDICTED: similar to orphan short-chain dehydrogenase / reductase
[Bos taurus]
Length = 313
Score = 327 bits (839), Expect = 1e-89
Identities = 159/302 (52%), Positives = 218/302 (72%)
Frame = +1
Query: 166 RWYRERQMVSHLGDKYVFIAGCDSGFGNLLARQLDVRGLRVLAACLTEQGAQQLRKQTSD 345
RW++ +V +L DKYVFI GCDSGFGNLLARQL RG+RVLAAC T++GAQ+L++ TS
Sbjct: 12 RWFKNCNLVRNLSDKYVFITGCDSGFGNLLARQLVDRGMRVLAACFTKEGAQKLQQDTSY 71
Query: 346 RLETVLLDVTKTESIAAATQWVKERVGDRGLWGLVNNAGTFHPLCITEWLKTETWIHTLK 525
+L+T+LLDVTKTESI AATQWV+++VG++GLW LVNNAG P EWL E ++ +
Sbjct: 72 QLQTILLDVTKTESIKAATQWVRDQVGEQGLWALVNNAGVGLPSGPNEWLTKEDFVKVIN 131
Query: 526 VNLIGVTEVTLSMLPLVKKAQGRIVNVSSILGRVAFFGAVYSSSKHGVEAFSDVLRCELQ 705
VNL+G+ EVTL MLP+VKKA+GR+VN+SS GRVA G Y SK GVEAFSD +R EL
Sbjct: 132 VNLVGLIEVTLHMLPMVKKARGRVVNMSSSGGRVAVIGGGYCISKFGVEAFSDSIRRELH 191
Query: 706 HFGVKVSIVEPGYFRTGMTDVQKSSEAMKQVWKEVPAHIKDTYGQKFFDAYHDVMKQGLS 885
+FGVKVSI+EPG FRT + + M+++W+ +P +++YG+++F Y D +K +
Sbjct: 192 YFGVKVSIIEPGNFRTAILGKDGLEKHMRKLWERLPPETRESYGEEYFRIYTDNLKSTMQ 251
Query: 886 SCSTNLNLVTDCMEHALTSVHPRTRYSAGWDAQFFFIPLSYLPTSLADYILTRSWPKPVQ 1065
++ VT+ MEHA+ S PR RY+ G DA+ ++PL+ PT + D+IL+R P+P
Sbjct: 252 LADPRISEVTNSMEHAIVSRSPRIRYNPGLDAKLLYLPLAKFPTPVTDFILSRYLPRPAD 311
Query: 1066 AV 1071
+V
Sbjct: 312 SV 313
>ref|NP_777158.1| NADP-dependent retinol dehydrogenase/reductase [Bos taurus]
Length = 319
Score = 305 bits (781), Expect = 6e-83
Identities = 146/293 (49%), Positives = 210/293 (71%), Gaps = 1/293 (0%)
Frame = +1
Query: 169 WYRERQM-VSHLGDKYVFIAGCDSGFGNLLARQLDVRGLRVLAACLTEQGAQQLRKQTSD 345
W +RQ+ ++++ DKY+FI GCD+GFGNL AR D +G V+AACLTE G+ L+ +TS+
Sbjct: 16 WNYKRQLKIANITDKYIFITGCDTGFGNLAARTFDKKGFHVIAACLTESGSTALKAETSE 75
Query: 346 RLETVLLDVTKTESIAAATQWVKERVGDRGLWGLVNNAGTFHPLCITEWLKTETWIHTLK 525
RL TVLLDVT E++ A QWVK +VG++GLWGL+NNAG L +WL E + ++
Sbjct: 76 RLHTVLLDVTDPENVKRAAQWVKNQVGEKGLWGLINNAGILGVLAPNDWLTVEDYREPVE 135
Query: 526 VNLIGVTEVTLSMLPLVKKAQGRIVNVSSILGRVAFFGAVYSSSKHGVEAFSDVLRCELQ 705
VNL G+ VTL+MLPLVKKA+GRI+NVSSI GR+AF G YS SK+ VE F+D LR +++
Sbjct: 136 VNLFGLISVTLNMLPLVKKARGRIINVSSIGGRLAFGGGGYSPSKYAVEGFNDSLRRDMK 195
Query: 706 HFGVKVSIVEPGYFRTGMTDVQKSSEAMKQVWKEVPAHIKDTYGQKFFDAYHDVMKQGLS 885
FGV V+ +EPG F+T ++D +K++E +WK + IK YG+ + + + +K S
Sbjct: 196 AFGVHVACIEPGLFKTNLSDPEKTAEKKLAIWKHLSPDIKQQYGESYIEKSLEQLKGTAS 255
Query: 886 SCSTNLNLVTDCMEHALTSVHPRTRYSAGWDAQFFFIPLSYLPTSLADYILTR 1044
+ +L+LV +CM+HALTS+ P+TRY+AG DA+ F+IPLS++P L D++L +
Sbjct: 256 FVNVDLSLVVECMDHALTSLFPKTRYAAGKDAKTFWIPLSHMPAVLQDFLLLK 308
>ref|NP_776591.1| retinol dehydrogenase 5 (11-cis and 9-cis) [Bos taurus]
Length = 319
Score = 275 bits (704), Expect = 5e-74
Identities = 139/288 (48%), Positives = 192/288 (66%), Gaps = 1/288 (0%)
Frame = +1
Query: 211 YVFIAGCDSGFGNLLARQLDVRGLRVLAACLTEQGAQQLRKQTSDRLETVLLDVTKTESI 390
++FI GCDSGFG LLA +LD RG RVLA+CLT GA+ L++ S RL T LLDVT +SI
Sbjct: 31 FIFITGCDSGFGRLLALRLDQRGFRVLASCLTPSGAEDLQRVASSRLHTTLLDVTDPQSI 90
Query: 391 AAATQWVKERVGDRGLWGLVNNAGTFHPLCITEWLKTETWIHTLKVNLIGVTEVTLSMLP 570
A +WV+ VG+ GL+GLVNNAG + T W E + L VN +G VTL++LP
Sbjct: 91 RQAVKWVETHVGEAGLFGLVNNAGVAGIIGPTPWQTREDFQRVLNVNTLGPIGVTLALLP 150
Query: 571 LVKKAQGRIVNVSSILGRVAFFGAVYSSSKHGVEAFSDVLRCELQHFGVKVSIVEPGYFR 750
L+ +A+GR++N++S+LGR+A G Y SK G+EAFSD LR ++ FGV+VSIVEPG+FR
Sbjct: 151 LLLQARGRVINITSVLGRLAANGGGYCVSKFGLEAFSDSLRRDVAPFGVRVSIVEPGFFR 210
Query: 751 TGMTDVQKSSEAMKQVWKEVPAHIKDTYGQKFFDAYHDVMKQGLSS-CSTNLNLVTDCME 927
T +T+++ + ++ W +P + YG+ F Y V ++ ++ C +L V+ C+E
Sbjct: 211 TPVTNLETLEDTLQACWARLPPATQALYGEAFLTKYLRVQQRIMNMICDPDLAKVSRCLE 270
Query: 928 HALTSVHPRTRYSAGWDAQFFFIPLSYLPTSLADYILTRSWPKPVQAV 1071
HALT+ HPRTRYS GWDA+ ++P SYLP L D +L PKP Q V
Sbjct: 271 HALTARHPRTRYSPGWDAKLLWLPASYLPARLVDAVLAWVLPKPAQTV 318
Database: RefSeqBP
Posted date: Aug 1, 2006 7:14 PM
Number of letters in database: 16,112,626
Number of sequences in database: 33,508
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 46,900,845
Number of Sequences: 33508
Number of extensions: 1146920
Number of successful extensions: 4304
Number of sequences better than 1.0e-05: 10
Number of HSP's better than 0.0 without gapping: 3451
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4260
length of database: 16,112,626
effective HSP length: 105
effective length of database: 12,594,286
effective search space used: 4785828680
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
Search to RefSeqCP
BLASTX 2.2.10 [Oct-19-2004]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= LVRM1_0096_C03
(1457 letters)
Database: RefSeqCP
33,732 sequences; 19,266,565 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
Alignment gi|XP_538239.2| PREDICTED: similar to 3-hydroxysteroid epimeras... 511 e-145
Alignment gi|XP_858059.1| PREDICTED: similar to 3-hydroxysteroid epimeras... 501 e-142
Alignment gi|XP_531641.2| PREDICTED: similar to microsomal NAD+-dependent... 392 e-109
Alignment gi|XP_858182.1| PREDICTED: similar to microsomal NAD+-dependent... 384 e-106
Alignment gi|XP_538240.2| PREDICTED: similar to orphan short-chain dehydr... 333 3e-91
Alignment gi|XP_545513.2| PREDICTED: similar to NADP-dependent retinol de... 302 6e-82
Alignment gi|XP_538220.2| PREDICTED: similar to 11-cis retinol dehydrogen... 294 1e-79
Alignment gi|XP_545160.2| PREDICTED: similar to 3-hydroxybutyrate dehydro... 184 2e-46
Alignment gi|XP_546810.2| PREDICTED: similar to hydroxysteroid (17-beta) ... 159 5e-39
Alignment gi|XP_853935.1| PREDICTED: similar to Corticosteroid 11-beta-de... 147 3e-35
>ref|XP_538239.2| PREDICTED: similar to 3-hydroxysteroid epimerase isoform 3 [Canis
familiaris]
Length = 317
Score = 511 bits (1316), Expect = e-145
Identities = 247/317 (77%), Positives = 272/317 (85%)
Frame = +1
Query: 121 MWXXXXXXXXXXXXXRWYRERQMVSHLGDKYVFIAGCDSGFGNLLARQLDVRGLRVLAAC 300
MW RWYRERQ+VSHL DKYVFI GCDSGFGNLLARQLD+RGLRVLAAC
Sbjct: 1 MWWSLAVLVGLYCLLRWYRERQVVSHLHDKYVFITGCDSGFGNLLARQLDLRGLRVLAAC 60
Query: 301 LTEQGAQQLRKQTSDRLETVLLDVTKTESIAAATQWVKERVGDRGLWGLVNNAGTFHPLC 480
LTE+GAQQLR QTSDRL+TV+LDVTKTESI AATQWV+ERVGDRGLWGLVNNAG FHP C
Sbjct: 61 LTEKGAQQLRSQTSDRLDTVILDVTKTESILAATQWVEERVGDRGLWGLVNNAGIFHPHC 120
Query: 481 ITEWLKTETWIHTLKVNLIGVTEVTLSMLPLVKKAQGRIVNVSSILGRVAFFGAVYSSSK 660
+EWLK E ++ KVNL G+ EVTLSMLPL+++A+GRIVNVSSILGR+AFFG Y SSK
Sbjct: 121 YSEWLKIEAYVDVFKVNLTGLIEVTLSMLPLLRRARGRIVNVSSILGRLAFFGGAYCSSK 180
Query: 661 HGVEAFSDVLRCELQHFGVKVSIVEPGYFRTGMTDVQKSSEAMKQVWKEVPAHIKDTYGQ 840
+GVEAFSD LR EL+HFGVK+SIVEPGYFRTGMT V E +KQ W+EVP HIK+ YGQ
Sbjct: 181 YGVEAFSDTLRRELRHFGVKISIVEPGYFRTGMTHVAWCLERLKQAWEEVPTHIKEAYGQ 240
Query: 841 KFFDAYHDVMKQGLSSCSTNLNLVTDCMEHALTSVHPRTRYSAGWDAQFFFIPLSYLPTS 1020
KFFDA+H+ +KQGL CSTNLNLVTDCMEHALTSVHPRTRYSAGWD+QFFFIPLSYLPTS
Sbjct: 241 KFFDAHHNGVKQGLLKCSTNLNLVTDCMEHALTSVHPRTRYSAGWDSQFFFIPLSYLPTS 300
Query: 1021 LADYILTRSWPKPVQAV 1071
LADYILTRSWPKP QAV
Sbjct: 301 LADYILTRSWPKPAQAV 317
>ref|XP_858059.1| PREDICTED: similar to 3-hydroxysteroid epimerase isoform 4 [Canis
familiaris]
Length = 323
Score = 501 bits (1289), Expect = e-142
Identities = 245/323 (75%), Positives = 271/323 (83%), Gaps = 6/323 (1%)
Frame = +1
Query: 121 MWXXXXXXXXXXXXXRWYRERQMVSHLGDKYVFIAGCDSGFGNLLARQLDVRGLRVLAAC 300
MW RWYRERQ+VSHL DKYVFI GCDSGFGNLLARQLD+RGLRVLAAC
Sbjct: 1 MWWSLAVLVGLYCLLRWYRERQVVSHLHDKYVFITGCDSGFGNLLARQLDLRGLRVLAAC 60
Query: 301 LTEQGAQQLRKQTSDRLETVLLDVTKTESIAAATQWVKERVGDRGLWGLVNNAGTFHPLC 480
LTE+GAQQLR QTSDRL+TV+LDVTKTESI AATQWV+ERVGDRGLWGLVNNAG FHP C
Sbjct: 61 LTEKGAQQLRSQTSDRLDTVILDVTKTESILAATQWVEERVGDRGLWGLVNNAGIFHPHC 120
Query: 481 ITEWLKTETWIHTLKVNLIGVTEVTLSMLPLVKKAQGRIVNVSSILGRVAFFGAVYSSSK 660
+EWLK E ++ KVNL G+ EVTLSMLPL+++A+GRIVNVSSILGR+AFFG Y SSK
Sbjct: 121 YSEWLKIEAYVDVFKVNLTGLIEVTLSMLPLLRRARGRIVNVSSILGRLAFFGGAYCSSK 180
Query: 661 HGVEAFSDVLRCELQHFGVKVSIVEPGYFRTGMTDVQKSSEAMKQVWKEVPAHIKDTYGQ 840
+GVEAFSD LR EL+HFGVK+SIVEPGYFRTGMT V E +KQ W+EVP HIK+ YGQ
Sbjct: 181 YGVEAFSDTLRRELRHFGVKISIVEPGYFRTGMTHVAWCLERLKQAWEEVPTHIKEAYGQ 240
Query: 841 KFFDAY------HDVMKQGLSSCSTNLNLVTDCMEHALTSVHPRTRYSAGWDAQFFFIPL 1002
KFF ++ H+ +KQGL CSTNLNLVTDCMEHALTSVHPRTRYSAGWD+QFFFIPL
Sbjct: 241 KFFASFLFLYTDHNGVKQGLLKCSTNLNLVTDCMEHALTSVHPRTRYSAGWDSQFFFIPL 300
Query: 1003 SYLPTSLADYILTRSWPKPVQAV 1071
SYLPTSLADYILTRSWPKP QAV
Sbjct: 301 SYLPTSLADYILTRSWPKPAQAV 323
>ref|XP_531641.2| PREDICTED: similar to microsomal NAD+-dependent retinol dehydrogenase
4 isoform 1 [Canis familiaris]
Length = 317
Score = 392 bits (1007), Expect = e-109
Identities = 190/317 (59%), Positives = 239/317 (75%)
Frame = +1
Query: 121 MWXXXXXXXXXXXXXRWYRERQMVSHLGDKYVFIAGCDSGFGNLLARQLDVRGLRVLAAC 300
MW RWYRERQ+VSHL DKYVFI GCDSGFGNLLARQLD+RGLRVLAAC
Sbjct: 1 MWWSLAVLVGLYYLLRWYRERQVVSHLQDKYVFITGCDSGFGNLLARQLDLRGLRVLAAC 60
Query: 301 LTEQGAQQLRKQTSDRLETVLLDVTKTESIAAATQWVKERVGDRGLWGLVNNAGTFHPLC 480
LTE+GAQQLR QTSDRL+TV+LDVTKTESI AATQWV+E VGDRGLWGLVNNAG P
Sbjct: 61 LTEKGAQQLRSQTSDRLDTVILDVTKTESILAATQWVEEHVGDRGLWGLVNNAGISWPTA 120
Query: 481 ITEWLKTETWIHTLKVNLIGVTEVTLSMLPLVKKAQGRIVNVSSILGRVAFFGAVYSSSK 660
EWL + ++ L VNL+G+ EVTLS+L LV+KA+GR+VNVSSI+GR++ G Y SK
Sbjct: 121 PNEWLTKDDFMKILDVNLLGLVEVTLSLLSLVRKARGRVVNVSSIMGRLSLCGGGYCISK 180
Query: 661 HGVEAFSDVLRCELQHFGVKVSIVEPGYFRTGMTDVQKSSEAMKQVWKEVPAHIKDTYGQ 840
+GVEAFSD LR EL +FGVKV+++EPGYF T +T+ +K S ++ W + +++ YG+
Sbjct: 181 YGVEAFSDSLRRELTYFGVKVAVIEPGYFSTNVTNPEKISRGFQETWDRLSPEVREAYGE 240
Query: 841 KFFDAYHDVMKQGLSSCSTNLNLVTDCMEHALTSVHPRTRYSAGWDAQFFFIPLSYLPTS 1020
+F + +++ S C TNL LVT+CMEHALT+ HPRTRYS GWDA+ ++P+SYLPT
Sbjct: 241 EFLASARKPIEKLKSMCDTNLYLVTNCMEHALTACHPRTRYSPGWDAKLLYLPMSYLPTL 300
Query: 1021 LADYILTRSWPKPVQAV 1071
L D ++ + P+P +AV
Sbjct: 301 LVDTMIYWNSPRPAKAV 317
>ref|XP_858182.1| PREDICTED: similar to microsomal NAD+-dependent retinol dehydrogenase
4 isoform 2 [Canis familiaris]
Length = 319
Score = 384 bits (987), Expect = e-106
Identities = 191/322 (59%), Positives = 239/322 (74%), Gaps = 5/322 (1%)
Frame = +1
Query: 121 MWXXXXXXXXXXXXXRWYRERQMVSHLGDKYVFIAGCDSGFGNLLARQLDVRGLRVLAAC 300
MW RWYRERQ+VSHL DKYVFI GCDSGFGNLLARQLD+RGLRVLAAC
Sbjct: 1 MWWSLAVLVGLYYLLRWYRERQVVSHLQDKYVFITGCDSGFGNLLARQLDLRGLRVLAAC 60
Query: 301 LTEQGAQQLRKQTSDRLETVLLDVTKTESIAAATQWVKERVGDRGLWGLVNNAGTFHPLC 480
LTE+GAQQLR QTSDRL+TV+LDVTKTESI AATQWV+E VGDRGLWGLVNNAG P
Sbjct: 61 LTEKGAQQLRSQTSDRLDTVILDVTKTESILAATQWVEEHVGDRGLWGLVNNAGISWPTA 120
Query: 481 ITEWLKTETWIHTLKVNLIGVTEVTLSMLPLVKKAQGRIVNVSSILGRVAFFGAVYSSSK 660
EWL + ++ L VNL+G+ EVTLS+L LV+KA+GR+VNVSSI+GR++ G Y SK
Sbjct: 121 PNEWLTKDDFMKILDVNLLGLVEVTLSLLSLVRKARGRVVNVSSIMGRLSLCGGGYCISK 180
Query: 661 HGVEAFSDVLRCELQHFGVKVSIVEPGYFRTGMTDVQKSSEAMKQVWKEVPAHIKDTYGQ 840
+GVEAFSD LR EL +FGVKV+++EPGYF T +T+ +K S ++ W + +++ YG+
Sbjct: 181 YGVEAFSDSLRRELTYFGVKVAVIEPGYFSTNVTNPEKISRGFQETWDRLSPEVREAYGE 240
Query: 841 KFFD-----AYHDVMKQGLSSCSTNLNLVTDCMEHALTSVHPRTRYSAGWDAQFFFIPLS 1005
+ A +++K S C TNL LVT+CMEHALT+ HPRTRYS GWDA+ ++P+S
Sbjct: 241 EHARTPGKLAVKELLK---SMCDTNLYLVTNCMEHALTACHPRTRYSPGWDAKLLYLPMS 297
Query: 1006 YLPTSLADYILTRSWPKPVQAV 1071
YLPT L D ++ + P+P +AV
Sbjct: 298 YLPTLLVDTMIYWNSPRPAKAV 319
>ref|XP_538240.2| PREDICTED: similar to orphan short-chain dehydrogenase / reductase
[Canis familiaris]
Length = 313
Score = 333 bits (853), Expect = 3e-91
Identities = 163/302 (53%), Positives = 217/302 (71%)
Frame = +1
Query: 166 RWYRERQMVSHLGDKYVFIAGCDSGFGNLLARQLDVRGLRVLAACLTEQGAQQLRKQTSD 345
RW + +V +L DKYVFI GCDSGFGNLLARQL RG+RVLAAC TE+GAQ+L++ TS
Sbjct: 12 RWLKNCNLVRNLSDKYVFITGCDSGFGNLLARQLVNRGMRVLAACFTEEGAQKLQRDTSY 71
Query: 346 RLETVLLDVTKTESIAAATQWVKERVGDRGLWGLVNNAGTFHPLCITEWLKTETWIHTLK 525
RL+T LLDVT+TESI AATQWV+++VG++GLW LVNNAG P EWL E ++ +
Sbjct: 72 RLQTTLLDVTRTESIQAATQWVRDQVGEQGLWALVNNAGIGLPSGPNEWLTKEDFVKVIN 131
Query: 526 VNLIGVTEVTLSMLPLVKKAQGRIVNVSSILGRVAFFGAVYSSSKHGVEAFSDVLRCELQ 705
VNL+G+ EVTL MLP+VKKA+GR+VN+SS GRVA G Y SK GVEAFSD +R EL
Sbjct: 132 VNLVGLIEVTLHMLPMVKKARGRVVNMSSSGGRVALIGGGYCVSKFGVEAFSDSIRRELH 191
Query: 706 HFGVKVSIVEPGYFRTGMTDVQKSSEAMKQVWKEVPAHIKDTYGQKFFDAYHDVMKQGLS 885
+FGVKVSI+EPG +RT + + M+++W+ +P KD+YG+++F Y D +K +
Sbjct: 192 YFGVKVSIIEPGNYRTSILGKEDMVSRMRKLWERLPQETKDSYGEEYFRNYTDKLKNMMQ 251
Query: 886 SCSTNLNLVTDCMEHALTSVHPRTRYSAGWDAQFFFIPLSYLPTSLADYILTRSWPKPVQ 1065
S + VT+ MEHA+ S PR RY+ G DA+ ++PL+ LPT + D+IL+R P+P
Sbjct: 252 SAEPRIREVTNSMEHAIVSRSPRVRYNPGLDAKLLYLPLAKLPTPVTDFILSRYLPRPAD 311
Query: 1066 AV 1071
+V
Sbjct: 312 SV 313
>ref|XP_545513.2| PREDICTED: similar to NADP-dependent retinol dehydrogenase/reductase
[Canis familiaris]
Length = 753
Score = 302 bits (773), Expect = 6e-82
Identities = 145/293 (49%), Positives = 207/293 (70%), Gaps = 1/293 (0%)
Frame = +1
Query: 169 WYRERQM-VSHLGDKYVFIAGCDSGFGNLLARQLDVRGLRVLAACLTEQGAQQLRKQTSD 345
W +RQ+ ++ + DKY+FI GCD+GFGNL AR D +G V+AACLTE + L+ +TS+
Sbjct: 450 WNYKRQLKIADITDKYIFITGCDTGFGNLAARTFDKKGFHVIAACLTESESTALKAETSE 509
Query: 346 RLETVLLDVTKTESIAAATQWVKERVGDRGLWGLVNNAGTFHPLCITEWLKTETWIHTLK 525
RL TVLLDVT E++ QWVK +VG++GLWGL+NNAG L T+WL E + ++
Sbjct: 510 RLHTVLLDVTDPENVKRTAQWVKNQVGEKGLWGLINNAGVLGVLAPTDWLTVEDYREPIE 569
Query: 526 VNLIGVTEVTLSMLPLVKKAQGRIVNVSSILGRVAFFGAVYSSSKHGVEAFSDVLRCELQ 705
VNL G+ VTL++LPLVKKA+GRI+NVSSI GR+A G Y+ SK+ VE F+D LR +++
Sbjct: 570 VNLFGLISVTLNLLPLVKKARGRIINVSSIGGRLAISGGGYTPSKYAVEGFNDSLRRDMK 629
Query: 706 HFGVKVSIVEPGYFRTGMTDVQKSSEAMKQVWKEVPAHIKDTYGQKFFDAYHDVMKQGLS 885
FGV VS +EPG F+TG++D K++E +WK + IK YG+ + + D +K S
Sbjct: 630 AFGVHVSCIEPGLFKTGLSDPIKATEKKLAIWKHLSPDIKQQYGESYIEKSLDKLKDTTS 689
Query: 886 SCSTNLNLVTDCMEHALTSVHPRTRYSAGWDAQFFFIPLSYLPTSLADYILTR 1044
+ +L+LV +CM+HALTS+ P+TRY+AG DA+ F+IPLS++P L D++L +
Sbjct: 690 FVNVDLSLVVECMDHALTSLFPKTRYAAGRDAKTFWIPLSHMPAVLQDFLLLK 742
>ref|XP_538220.2| PREDICTED: similar to 11-cis retinol dehydrogenase (11-cis RDH)
[Canis familiaris]
Length = 339
Score = 294 bits (753), Expect = 1e-79
Identities = 154/330 (46%), Positives = 211/330 (63%), Gaps = 1/330 (0%)
Frame = +1
Query: 85 LPNKHFSGGPHTMWXXXXXXXXXXXXXRWYRERQMVSHLGDKYVFIAGCDSGFGNLLARQ 264
LP SG MW W R++Q + D +VFI GCDSGFG LLA +
Sbjct: 12 LPPAGHSGS--AMWLPLLLGVLLWAVLWWLRDQQSLP-ASDAFVFITGCDSGFGRLLALR 68
Query: 265 LDVRGLRVLAACLTEQGAQQLRKQTSDRLETVLLDVTKTESIAAATQWVKERVGDRGLWG 444
LD RG RVLA+CLT GA+ L++ S RL T LLDVT+ +S+ A +WV+ VG+ GL+G
Sbjct: 69 LDQRGFRVLASCLTPAGAEDLQRVASSRLHTTLLDVTEPQSVQRAAKWVETHVGEAGLFG 128
Query: 445 LVNNAGTFHPLCITEWLKTETWIHTLKVNLIGVTEVTLSMLPLVKKAQGRIVNVSSILGR 624
LVNNAG + T WL + + L VN +G VTL++LPL+++++GR+VN+SS+LGR
Sbjct: 129 LVNNAGVAGIIGPTPWLTQDDFHRVLNVNTLGPIRVTLALLPLLQQSRGRVVNISSVLGR 188
Query: 625 VAFFGAVYSSSKHGVEAFSDVLRCELQHFGVKVSIVEPGYFRTGMTDVQKSSEAMKQVWK 804
+A G Y SK G+EAFSD LR ++ HFGV+VSIVEPG+FRT +T+++ +++ W
Sbjct: 189 LAANGGGYCVSKFGLEAFSDSLRRDVAHFGVRVSIVEPGFFRTPVTNLEHLENTLQECWA 248
Query: 805 EVPAHIKDTYGQKFFDAYHDVMKQGLS-SCSTNLNLVTDCMEHALTSVHPRTRYSAGWDA 981
+P + YG+ F Y V + +S C +L V+ C+EHALT+ +PRTRYS GWDA
Sbjct: 249 RLPPSTQAHYGEAFLPKYLQVQQHIMSLICDPDLTKVSRCLEHALTARYPRTRYSPGWDA 308
Query: 982 QFFFIPLSYLPTSLADYILTRSWPKPVQAV 1071
+ ++P SYLP SL D +LT PKP QAV
Sbjct: 309 KLLWLPASYLPASLVDAVLTWVLPKPAQAV 338
>ref|XP_545160.2| PREDICTED: similar to 3-hydroxybutyrate dehydrogenase precursor
[Canis familiaris]
Length = 299
Score = 184 bits (466), Expect = 2e-46
Identities = 110/270 (40%), Positives = 162/270 (60%), Gaps = 11/270 (4%)
Frame = +1
Query: 187 MVSHLGDKYVFIAGCDSGFGNLLARQLDVRGLRVLAACLTEQ----GAQQLRKQTSDRLE 354
++ +G K V + GCDSGFG LA+ L +G V A CL + G ++L SDRL
Sbjct: 5 LLKQVGSKAVLVTGCDSGFGFSLAKHLHSKGFLVFAGCLMKDQGGDGVKELDGLKSDRLR 64
Query: 355 TVLLDVTKTESIAAATQWVKERVGD--RGLWGLVNNAG--TFHPLCITEWLKTETWIHTL 522
T+ L+V K E + + V+ + D +G+WGLVNNAG TF + E+ ET+
Sbjct: 65 TIQLNVCKGEEVERVVEVVRSSLEDPEKGMWGLVNNAGISTFGEV---EFTSMETYKEVA 121
Query: 523 KVNLIGVTEVTLSMLPLVKKAQGRIVNVSSILGRVAF-FGAVYSSSKHGVEAFSDVLRCE 699
+VNL G ++T + LPL+++A+GRIVN+SS+LGR+A + Y +K GVEAFSD LR E
Sbjct: 122 EVNLWGTVQMTKAFLPLIRRARGRIVNISSMLGRMANPARSPYCITKFGVEAFSDCLRYE 181
Query: 700 LQHFGVKVSIVEPGYF--RTGMTDVQKSSEAMKQVWKEVPAHIKDTYGQKFFDAYHDVMK 873
+ GVKVS+VEPG F T + + ++ ++W E+P ++ YG+K+FD M+
Sbjct: 182 MYPLGVKVSVVEPGNFIAATSLYNPERIQAIADKMWDELPEVVRKDYGRKYFDEKIARMQ 241
Query: 874 QGLSSCSTNLNLVTDCMEHALTSVHPRTRY 963
+S ST+++ V + HALTS P TRY
Sbjct: 242 AYCNSGSTDISPVVSAVTHALTSRSPYTRY 271
>ref|XP_546810.2| PREDICTED: similar to hydroxysteroid (17-beta) dehydrogenase 2 [Canis
familiaris]
Length = 382
Score = 159 bits (403), Expect = 5e-39
Identities = 99/291 (34%), Positives = 157/291 (53%), Gaps = 4/291 (1%)
Frame = +1
Query: 172 YRERQMVSHLGDKYVFIAGCDSGFGNLLARQLDVRGLRVLAACLTEQG--AQQLRKQTSD 345
Y Q + + K V I G DSGFG+ L++ LD G V L E+G A++LR+ S
Sbjct: 72 YLSGQELLPVDQKAVLITGGDSGFGHALSKYLDELGFTVFVGVLDEKGSGAEELRRTCSK 131
Query: 346 RLETVLLDVTKTESIAAATQWVKERVGDRGLWGLVNNAGTFHPLCITEWLKTETWIHTLK 525
RL + +D+T + I A V E++ DRGLW +VNNAG E + + +
Sbjct: 132 RLSVLQMDITDQQQIKDAHSKVVEKLQDRGLWAVVNNAGIICLPADGELIPMTDYKKCMA 191
Query: 526 VNLIGVTEVTLSMLPLVKKAQGRIVNVSSILGRVAFFG-AVYSSSKHGVEAFSDVLRCEL 702
VN G EVT + LPL++K++GR+VN+SS+ V A YSSSK + FS V+R EL
Sbjct: 192 VNFFGAVEVTKAFLPLLRKSKGRLVNISSMAAGVPMEKLAAYSSSKAALTMFSAVMRQEL 251
Query: 703 QHFGVKVSIVEPGYFRTGMTDVQKS-SEAMKQVWKEVPAHIKDTYGQKFFDAYHDVMKQG 879
+GVKVS+++PG FRT + + S+ K + + + +++ YG+ + + +K
Sbjct: 252 SKWGVKVSVIQPGGFRTNIAGTSEMWSKLEKNILDHLSSDVEEDYGKDYILQQRNYLKSI 311
Query: 880 LSSCSTNLNLVTDCMEHALTSVHPRTRYSAGWDAQFFFIPLSYLPTSLADY 1032
+T+++ V + HA+++ P Y+ G A +S+ PT + DY
Sbjct: 312 NIKTNTDISPVLQDIRHAVSAKSPFAFYAPGALAYCLLFFVSFSPTGIFDY 362
>ref|XP_853935.1| PREDICTED: similar to Corticosteroid 11-beta-dehydrogenase, isozyme 2
(11-DH2) (11-beta-hydroxysteroid dehydrogenase type 2)
(11-beta-HSD2) (NAD-dependent 11-beta-hydroxysteroid
dehydrogenase) [Canis familiaris]
Length = 323
Score = 147 bits (371), Expect = 3e-35
Identities = 91/269 (33%), Positives = 135/269 (50%), Gaps = 4/269 (1%)
Frame = +1
Query: 229 CDSGFGNLLARQLDVRGLRVLAACLTEQG--AQQLRKQTSDRLETVLLDVTKTESIAAAT 402
CDSGFG A++LD G VLA L G A +LR S RL + +D+TK I+ A
Sbjct: 8 CDSGFGKETAKKLDAMGFTVLATVLELDGPGALELRACCSPRLRLLQMDLTKPADISRAL 67
Query: 403 QWVKERVGDRGLWGLVNNAGTFHPLCITEWLKTETWIHTLKVNLIGVTEVTLSMLPLVKK 582
++ K GLWGLVNNAG + E T+ ++VN G E+T +LPL+++
Sbjct: 68 EFTKAHTSSTGLWGLVNNAGHNDVVADVELSPVATFRSCMEVNFFGALELTKGLLPLLRR 127
Query: 583 AQGRIVNVSSILGRVAF-FGAVYSSSKHGVEAFSDVLRCELQHFGVKVSIVEPGYFRT-G 756
++GRIV V S G + + A Y +SK + D CEL +GVKVS+++PG F+T
Sbjct: 128 SRGRIVTVGSPAGDMPYPCLAAYGTSKAAMALLMDTFSCELLPWGVKVSVIQPGCFKTES 187
Query: 757 MTDVQKSSEAMKQVWKEVPAHIKDTYGQKFFDAYHDVMKQGLSSCSTNLNLVTDCMEHAL 936
+ +V + + + +P + YG+ + + H L +L+ V D + AL
Sbjct: 188 VRNVGHWEQRKQLLLASLPRELLQAYGEDYIEHLHGQFLHSLRLALPDLSPVVDAITDAL 247
Query: 937 TSVHPRTRYSAGWDAQFFFIPLSYLPTSL 1023
+ PR RY G + YLP L
Sbjct: 248 LAAQPRRRYYPGRGLGLMYFIHYYLPEGL 276
Database: RefSeqCP
Posted date: Aug 1, 2006 9:25 PM
Number of letters in database: 19,266,565
Number of sequences in database: 33,732
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 54,995,481
Number of Sequences: 33732
Number of extensions: 1341524
Number of successful extensions: 4986
Number of sequences better than 1.0e-05: 10
Number of HSP's better than 0.0 without gapping: 3972
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4951
length of database: 19,266,565
effective HSP length: 107
effective length of database: 15,657,241
effective search space used: 5918437098
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
Search to RefSeqHP
BLASTX 2.2.10 [Oct-19-2004]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= LVRM1_0096_C03
(1457 letters)
Database: RefSeqHP
39,411 sequences; 17,774,539 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
Alignment gi|NP_003716.2| 3-hydroxysteroid epimerase [Homo sapiens] 499 e-141
Alignment gi|NP_003699.2| retinol dehydrogenase 16 [Homo sapiens] 370 e-102
Alignment gi|NP_683695.1| orphan short-chain dehydrogenase / reductase [H... 317 2e-86
Alignment gi|NP_005762.2| NADP-dependent retinol dehydrogenase/reductase ... 295 7e-80
Alignment gi|NP_954674.1| NADP-dependent retinol dehydrogenase/reductase ... 295 7e-80
Alignment gi|NP_002896.2| retinol dehydrogenase 5 (11-cis and 9-cis) [Hom... 283 3e-76
Alignment gi|NP_976059.1| 3-hydroxybutyrate dehydrogenase precursor [Homo... 188 1e-47
Alignment gi|NP_976060.1| 3-hydroxybutyrate dehydrogenase precursor [Homo... 188 1e-47
Alignment gi|NP_004042.1| 3-hydroxybutyrate dehydrogenase precursor [Homo... 188 1e-47
Alignment gi|NP_002144.1| hydroxysteroid (17-beta) dehydrogenase 2 [Homo ... 155 8e-38
>ref|NP_003716.2| 3-hydroxysteroid epimerase [Homo sapiens]
Length = 317
Score = 499 bits (1285), Expect = e-141
Identities = 244/317 (76%), Positives = 271/317 (85%)
Frame = +1
Query: 121 MWXXXXXXXXXXXXXRWYRERQMVSHLGDKYVFIAGCDSGFGNLLARQLDVRGLRVLAAC 300
MW WYRERQ+VSHL DKYVFI GCDSGFGNLLARQLD RGLRVLAAC
Sbjct: 1 MWLYLAAFVGLYYLLHWYRERQVVSHLQDKYVFITGCDSGFGNLLARQLDARGLRVLAAC 60
Query: 301 LTEQGAQQLRKQTSDRLETVLLDVTKTESIAAATQWVKERVGDRGLWGLVNNAGTFHPLC 480
LTE+GA+QLR QTSDRLETV LDVTK ESIAAATQWVKE VGDRGLWGLVNNAG P+
Sbjct: 61 LTEKGAEQLRGQTSDRLETVTLDVTKMESIAAATQWVKEHVGDRGLWGLVNNAGILTPIT 120
Query: 481 ITEWLKTETWIHTLKVNLIGVTEVTLSMLPLVKKAQGRIVNVSSILGRVAFFGAVYSSSK 660
+ EWL TE ++ LKVNLIGV +VTLSMLPLV++A+GRIVNVSSILGRVAFF Y SK
Sbjct: 121 LCEWLNTEDSMNMLKVNLIGVIQVTLSMLPLVRRARGRIVNVSSILGRVAFFVGGYCVSK 180
Query: 661 HGVEAFSDVLRCELQHFGVKVSIVEPGYFRTGMTDVQKSSEAMKQVWKEVPAHIKDTYGQ 840
+GVEAFSD+LR E+QHFGVK+SIVEPGYFRTGMT++ +S E MKQ WKE P HIK+TYGQ
Sbjct: 181 YGVEAFSDILRREIQHFGVKISIVEPGYFRTGMTNMTQSLERMKQSWKEAPKHIKETYGQ 240
Query: 841 KFFDAYHDVMKQGLSSCSTNLNLVTDCMEHALTSVHPRTRYSAGWDAQFFFIPLSYLPTS 1020
++FDA +++MK+GL +CSTNLNLVTDCMEHALTSVHPRTRYSAGWDA+FFFIPLSYLPTS
Sbjct: 241 QYFDALYNIMKEGLLNCSTNLNLVTDCMEHALTSVHPRTRYSAGWDAKFFFIPLSYLPTS 300
Query: 1021 LADYILTRSWPKPVQAV 1071
LADYILTRSWPKP QAV
Sbjct: 301 LADYILTRSWPKPAQAV 317
>ref|NP_003699.2| retinol dehydrogenase 16 [Homo sapiens]
Length = 317
Score = 370 bits (950), Expect = e-102
Identities = 181/317 (57%), Positives = 230/317 (72%)
Frame = +1
Query: 121 MWXXXXXXXXXXXXXRWYRERQMVSHLGDKYVFIAGCDSGFGNLLARQLDVRGLRVLAAC 300
MW WYRERQ++SHL DKYVFI GCDSGFG LLARQLD RGLRVLAAC
Sbjct: 1 MWLYLAVFVGLYYLLHWYRERQVLSHLRDKYVFITGCDSGFGKLLARQLDARGLRVLAAC 60
Query: 301 LTEQGAQQLRKQTSDRLETVLLDVTKTESIAAATQWVKERVGDRGLWGLVNNAGTFHPLC 480
LTE+GA+QLR QTSDRLETV LDVTKTES+AAA QWVKE V D+GLWGLVNNAG P
Sbjct: 61 LTEKGAEQLRGQTSDRLETVTLDVTKTESVAAAAQWVKECVRDKGLWGLVNNAGISLPTA 120
Query: 481 ITEWLKTETWIHTLKVNLIGVTEVTLSMLPLVKKAQGRIVNVSSILGRVAFFGAVYSSSK 660
E L + + L VNL+GV +VTL++LPLV++A+GR+VNV S++GRV+ FG Y SK
Sbjct: 121 PNELLTKQDLLTILDVNLLGVIDVTLNLLPLVRRARGRVVNVFSVMGRVSLFGGGYCISK 180
Query: 661 HGVEAFSDVLRCELQHFGVKVSIVEPGYFRTGMTDVQKSSEAMKQVWKEVPAHIKDTYGQ 840
+GVEAFSD LR EL +FGVKV+++EPGYF+T +T ++ ++ ++W +K+ YG+
Sbjct: 181 YGVEAFSDSLRRELSYFGVKVAMIEPGYFKTAVTSKERFLKSFLEIWDRSSPEVKEAYGE 240
Query: 841 KFFDAYHDVMKQGLSSCSTNLNLVTDCMEHALTSVHPRTRYSAGWDAQFFFIPLSYLPTS 1020
KF Y +Q C+ +L+LVT+CMEHAL + HPRTRYSAGWDA+ ++P+SY+PT
Sbjct: 241 KFVADYKKSAEQMEQKCTQDLSLVTNCMEHALIACHPRTRYSAGWDAKLLYLPMSYMPTF 300
Query: 1021 LADYILTRSWPKPVQAV 1071
L D I+ P P +A+
Sbjct: 301 LVDAIMYWVSPSPAKAL 317
>ref|NP_683695.1| orphan short-chain dehydrogenase / reductase [Homo sapiens]
Length = 313
Score = 317 bits (811), Expect = 2e-86
Identities = 153/302 (50%), Positives = 213/302 (70%)
Frame = +1
Query: 166 RWYRERQMVSHLGDKYVFIAGCDSGFGNLLARQLDVRGLRVLAACLTEQGAQQLRKQTSD 345
RW++ +V +L +KYVFI GCDSGFGNLLA+QL RG++VLAAC TE+G+Q+L++ TS
Sbjct: 12 RWFKNCNLVGNLSEKYVFITGCDSGFGNLLAKQLVDRGMQVLAACFTEEGSQKLQRDTSY 71
Query: 346 RLETVLLDVTKTESIAAATQWVKERVGDRGLWGLVNNAGTFHPLCITEWLKTETWIHTLK 525
RL+T LLDVTK+ESI AA QWV+++VG++GLW LVNNAG P EWL + ++ +
Sbjct: 72 RLQTTLLDVTKSESIKAAAQWVRDKVGEQGLWALVNNAGVGLPSGPNEWLTKDDFVKVIN 131
Query: 526 VNLIGVTEVTLSMLPLVKKAQGRIVNVSSILGRVAFFGAVYSSSKHGVEAFSDVLRCELQ 705
VNL+G+ EVTL MLP+VK+A+GR+VN+SS GRVA G Y SK GVEAFSD +R EL
Sbjct: 132 VNLVGLIEVTLHMLPMVKRARGRVVNMSSSGGRVAVIGGGYCVSKFGVEAFSDSIRRELY 191
Query: 706 HFGVKVSIVEPGYFRTGMTDVQKSSEAMKQVWKEVPAHIKDTYGQKFFDAYHDVMKQGLS 885
+FGVKV I+EPG +RT + + M+++W+ +P +D+YG+ +F Y D +K +
Sbjct: 192 YFGVKVCIIEPGNYRTAILGKENLESRMRKLWERLPQETRDSYGEDYFRIYTDKLKNIMQ 251
Query: 886 SCSTNLNLVTDCMEHALTSVHPRTRYSAGWDAQFFFIPLSYLPTSLADYILTRSWPKPVQ 1065
+ V + MEHA+ S PR RY+ G DA+ +IPL+ LPT + D+IL+R P+P
Sbjct: 252 VAEPRVRDVINSMEHAIVSRSPRIRYNPGLDAKLLYIPLAKLPTPVTDFILSRYLPRPAD 311
Query: 1066 AV 1071
+V
Sbjct: 312 SV 313
>ref|NP_005762.2| NADP-dependent retinol dehydrogenase/reductase [Homo sapiens]
Length = 319
Score = 295 bits (755), Expect = 7e-80
Identities = 142/293 (48%), Positives = 203/293 (69%), Gaps = 1/293 (0%)
Frame = +1
Query: 169 WYRERQM-VSHLGDKYVFIAGCDSGFGNLLARQLDVRGLRVLAACLTEQGAQQLRKQTSD 345
W R+ ++ + + DKY+FI GCDSGFGNL AR D +G V+AACLTE G+ L+ +TS+
Sbjct: 16 WTRKGKLKIEDITDKYIFITGCDSGFGNLAARTFDKKGFHVIAACLTESGSTALKAETSE 75
Query: 346 RLETVLLDVTKTESIAAATQWVKERVGDRGLWGLVNNAGTFHPLCITEWLKTETWIHTLK 525
RL TVLLDVT E++ QWVK +VG++GLWGL+NNAG L T+WL E + ++
Sbjct: 76 RLRTVLLDVTDPENVKRTAQWVKNQVGEKGLWGLINNAGVPGVLAPTDWLTLEDYREPIE 135
Query: 526 VNLIGVTEVTLSMLPLVKKAQGRIVNVSSILGRVAFFGAVYSSSKHGVEAFSDVLRCELQ 705
VNL G+ VTL+MLPLVKKAQGR++NVSS+ GR+A G Y+ SK+ VE F+D LR +++
Sbjct: 136 VNLFGLISVTLNMLPLVKKAQGRVINVSSVGGRLAIVGGGYTPSKYAVEGFNDSLRRDMK 195
Query: 706 HFGVKVSIVEPGYFRTGMTDVQKSSEAMKQVWKEVPAHIKDTYGQKFFDAYHDVMKQGLS 885
FGV VS +EPG F+T + D K E +W+++ IK YG+ + + D +K S
Sbjct: 196 AFGVHVSCIEPGLFKTNLADPVKVIEKKLAIWEQLSPDIKQQYGEGYIEKSLDKLKGNKS 255
Query: 886 SCSTNLNLVTDCMEHALTSVHPRTRYSAGWDAQFFFIPLSYLPTSLADYILTR 1044
+ +L+ V +CM+HALTS+ P+T Y+AG DA+ F+IPLS++P +L D++L +
Sbjct: 256 YVNMDLSPVVECMDHALTSLFPKTHYAAGKDAKIFWIPLSHMPAALQDFLLLK 308
>ref|NP_954674.1| NADP-dependent retinol dehydrogenase/reductase [Homo sapiens]
Length = 319
Score = 295 bits (755), Expect = 7e-80
Identities = 142/293 (48%), Positives = 203/293 (69%), Gaps = 1/293 (0%)
Frame = +1
Query: 169 WYRERQM-VSHLGDKYVFIAGCDSGFGNLLARQLDVRGLRVLAACLTEQGAQQLRKQTSD 345
W R+ ++ + + DKY+FI GCDSGFGNL AR D +G V+AACLTE G+ L+ +TS+
Sbjct: 16 WTRKGKLKIEDITDKYIFITGCDSGFGNLAARTFDKKGFHVIAACLTESGSTALKAETSE 75
Query: 346 RLETVLLDVTKTESIAAATQWVKERVGDRGLWGLVNNAGTFHPLCITEWLKTETWIHTLK 525
RL TVLLDVT E++ QWVK +VG++GLWGL+NNAG L T+WL E + ++
Sbjct: 76 RLRTVLLDVTDPENVKRTAQWVKNQVGEKGLWGLINNAGVPGVLAPTDWLTLEDYREPIE 135
Query: 526 VNLIGVTEVTLSMLPLVKKAQGRIVNVSSILGRVAFFGAVYSSSKHGVEAFSDVLRCELQ 705
VNL G+ VTL+MLPLVKKAQGR++NVSS+ GR+A G Y+ SK+ VE F+D LR +++
Sbjct: 136 VNLFGLISVTLNMLPLVKKAQGRVINVSSVGGRLAIVGGGYTPSKYAVEGFNDSLRRDMK 195
Query: 706 HFGVKVSIVEPGYFRTGMTDVQKSSEAMKQVWKEVPAHIKDTYGQKFFDAYHDVMKQGLS 885
FGV VS +EPG F+T + D K E +W+++ IK YG+ + + D +K S
Sbjct: 196 AFGVHVSCIEPGLFKTNLADPVKVIEKKLAIWEQLSPDIKQQYGEGYIEKSLDKLKGNKS 255
Query: 886 SCSTNLNLVTDCMEHALTSVHPRTRYSAGWDAQFFFIPLSYLPTSLADYILTR 1044
+ +L+ V +CM+HALTS+ P+T Y+AG DA+ F+IPLS++P +L D++L +
Sbjct: 256 YVNMDLSPVVECMDHALTSLFPKTHYAAGKDAKIFWIPLSHMPAALQDFLLLK 308
>ref|NP_002896.2| retinol dehydrogenase 5 (11-cis and 9-cis) [Homo sapiens]
Length = 318
Score = 283 bits (723), Expect = 3e-76
Identities = 143/300 (47%), Positives = 202/300 (67%), Gaps = 1/300 (0%)
Frame = +1
Query: 175 RERQMVSHLGDKYVFIAGCDSGFGNLLARQLDVRGLRVLAACLTEQGAQQLRKQTSDRLE 354
R+RQ + + +VFI GCDSGFG LLA QLD RG RVLA+CLT GA+ L++ S RL
Sbjct: 19 RDRQSLP-ASNAFVFITGCDSGFGRLLALQLDQRGFRVLASCLTPSGAEDLQRVASSRLH 77
Query: 355 TVLLDVTKTESIAAATQWVKERVGDRGLWGLVNNAGTFHPLCITEWLKTETWIHTLKVNL 534
T LLD+T +S+ A +WV+ V + GL+GLVNNAG + T WL + + L VN
Sbjct: 78 TTLLDITDPQSVQQAAKWVEMHVKEAGLFGLVNNAGVAGIIGPTPWLTRDDFQRVLNVNT 137
Query: 535 IGVTEVTLSMLPLVKKAQGRIVNVSSILGRVAFFGAVYSSSKHGVEAFSDVLRCELQHFG 714
+G VTL++LPL+++A+GR++N++S+LGR+A G Y SK G+EAFSD LR ++ HFG
Sbjct: 138 MGPIGVTLALLPLLQQARGRVINITSVLGRLAANGGGYCVSKFGLEAFSDSLRRDVAHFG 197
Query: 715 VKVSIVEPGYFRTGMTDVQKSSEAMKQVWKEVPAHIKDTYGQKFFDAYHDVMKQGLS-SC 891
++VSIVEPG+FRT +T+++ + ++ W +P + YG F Y + ++ ++ C
Sbjct: 198 IRVSIVEPGFFRTPVTNLESLEKTLQACWARLPPATQAHYGGAFLTKYLKMQQRIMNLIC 257
Query: 892 STNLNLVTDCMEHALTSVHPRTRYSAGWDAQFFFIPLSYLPTSLADYILTRSWPKPVQAV 1071
+L V+ C+EHALT+ HPRTRYS GWDA+ ++P SYLP SL D +LT PKP QAV
Sbjct: 258 DPDLTKVSRCLEHALTARHPRTRYSPGWDAKLLWLPASYLPASLVDAVLTWVLPKPAQAV 317
>ref|NP_976059.1| 3-hydroxybutyrate dehydrogenase precursor [Homo sapiens]
Length = 343
Score = 188 bits (477), Expect = 1e-47
Identities = 118/296 (39%), Positives = 172/296 (58%), Gaps = 14/296 (4%)
Frame = +1
Query: 199 LGDKYVFIAGCDSGFGNLLARQLDVRGLRVLAACLTEQ----GAQQLRKQTSDRLETVLL 366
+G K V + GCDSGFG LA+ L +G V A CL + G ++L SDRL TV L
Sbjct: 53 VGSKAVLVTGCDSGFGFSLAKHLHSKGFLVFAGCLMKDKGHDGVKELDSLNSDRLRTVQL 112
Query: 367 DVTKTESIAAATQWVKERVGD--RGLWGLVNNAG--TFHPLCITEWLKTETWIHTLKVNL 534
+V +E + + V+ + D +G+WGLVNNAG TF + E+ ET+ +VNL
Sbjct: 113 NVCSSEEVEKVVEIVRSSLKDPEKGMWGLVNNAGISTFGEV---EFTSLETYKQVAEVNL 169
Query: 535 IGVTEVTLSMLPLVKKAQGRIVNVSSILGRVAF-FGAVYSSSKHGVEAFSDVLRCELQHF 711
G +T S LPL+++A+GR+VN+SS+LGR+A + Y +K GVEAFSD LR E+
Sbjct: 170 WGTVRMTKSFLPLIRRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDCLRYEMYPL 229
Query: 712 GVKVSIVEPGYF--RTGMTDVQKSSEAMKQVWKEVPAHIKDTYGQKFFDAYHDVMKQGLS 885
GVKVS+VEPG F T + + K++W+E+P ++ YG+K+FD M+ S
Sbjct: 230 GVKVSVVEPGNFIAATSLYSPESIQAIAKKMWEELPEVVRKDYGKKYFDEKIAKMETYCS 289
Query: 886 SCSTNLNLVTDCMEHALTSVHPRTRY---SAGWDAQFFFIPLSYLPTSLADYILTR 1044
S ST+ + V D + HALT+ P TRY W + +++LP +++D I R
Sbjct: 290 SGSTDTSPVIDAVTHALTATTPYTRYHPMDYYWWLRMQI--MTHLPGAISDMIYIR 343
>ref|NP_976060.1| 3-hydroxybutyrate dehydrogenase precursor [Homo sapiens]
Length = 343
Score = 188 bits (477), Expect = 1e-47
Identities = 118/296 (39%), Positives = 172/296 (58%), Gaps = 14/296 (4%)
Frame = +1
Query: 199 LGDKYVFIAGCDSGFGNLLARQLDVRGLRVLAACLTEQ----GAQQLRKQTSDRLETVLL 366
+G K V + GCDSGFG LA+ L +G V A CL + G ++L SDRL TV L
Sbjct: 53 VGSKAVLVTGCDSGFGFSLAKHLHSKGFLVFAGCLMKDKGHDGVKELDSLNSDRLRTVQL 112
Query: 367 DVTKTESIAAATQWVKERVGD--RGLWGLVNNAG--TFHPLCITEWLKTETWIHTLKVNL 534
+V +E + + V+ + D +G+WGLVNNAG TF + E+ ET+ +VNL
Sbjct: 113 NVCSSEEVEKVVEIVRSSLKDPEKGMWGLVNNAGISTFGEV---EFTSLETYKQVAEVNL 169
Query: 535 IGVTEVTLSMLPLVKKAQGRIVNVSSILGRVAF-FGAVYSSSKHGVEAFSDVLRCELQHF 711
G +T S LPL+++A+GR+VN+SS+LGR+A + Y +K GVEAFSD LR E+
Sbjct: 170 WGTVRMTKSFLPLIRRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDCLRYEMYPL 229
Query: 712 GVKVSIVEPGYF--RTGMTDVQKSSEAMKQVWKEVPAHIKDTYGQKFFDAYHDVMKQGLS 885
GVKVS+VEPG F T + + K++W+E+P ++ YG+K+FD M+ S
Sbjct: 230 GVKVSVVEPGNFIAATSLYSPESIQAIAKKMWEELPEVVRKDYGKKYFDEKIAKMETYCS 289
Query: 886 SCSTNLNLVTDCMEHALTSVHPRTRY---SAGWDAQFFFIPLSYLPTSLADYILTR 1044
S ST+ + V D + HALT+ P TRY W + +++LP +++D I R
Sbjct: 290 SGSTDTSPVIDAVTHALTATTPYTRYHPMDYYWWLRMQI--MTHLPGAISDMIYIR 343
>ref|NP_004042.1| 3-hydroxybutyrate dehydrogenase precursor [Homo sapiens]
Length = 343
Score = 188 bits (477), Expect = 1e-47
Identities = 118/296 (39%), Positives = 172/296 (58%), Gaps = 14/296 (4%)
Frame = +1
Query: 199 LGDKYVFIAGCDSGFGNLLARQLDVRGLRVLAACLTEQ----GAQQLRKQTSDRLETVLL 366
+G K V + GCDSGFG LA+ L +G V A CL + G ++L SDRL TV L
Sbjct: 53 VGSKAVLVTGCDSGFGFSLAKHLHSKGFLVFAGCLMKDKGHDGVKELDSLNSDRLRTVQL 112
Query: 367 DVTKTESIAAATQWVKERVGD--RGLWGLVNNAG--TFHPLCITEWLKTETWIHTLKVNL 534
+V +E + + V+ + D +G+WGLVNNAG TF + E+ ET+ +VNL
Sbjct: 113 NVCSSEEVEKVVEIVRSSLKDPEKGMWGLVNNAGISTFGEV---EFTSLETYKQVAEVNL 169
Query: 535 IGVTEVTLSMLPLVKKAQGRIVNVSSILGRVAF-FGAVYSSSKHGVEAFSDVLRCELQHF 711
G +T S LPL+++A+GR+VN+SS+LGR+A + Y +K GVEAFSD LR E+
Sbjct: 170 WGTVRMTKSFLPLIRRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDCLRYEMYPL 229
Query: 712 GVKVSIVEPGYF--RTGMTDVQKSSEAMKQVWKEVPAHIKDTYGQKFFDAYHDVMKQGLS 885
GVKVS+VEPG F T + + K++W+E+P ++ YG+K+FD M+ S
Sbjct: 230 GVKVSVVEPGNFIAATSLYSPESIQAIAKKMWEELPEVVRKDYGKKYFDEKIAKMETYCS 289
Query: 886 SCSTNLNLVTDCMEHALTSVHPRTRY---SAGWDAQFFFIPLSYLPTSLADYILTR 1044
S ST+ + V D + HALT+ P TRY W + +++LP +++D I R
Sbjct: 290 SGSTDTSPVIDAVTHALTATTPYTRYHPMDYYWWLRMQI--MTHLPGAISDMIYIR 343
>ref|NP_002144.1| hydroxysteroid (17-beta) dehydrogenase 2 [Homo sapiens]
Length = 387
Score = 155 bits (392), Expect = 8e-38
Identities = 100/295 (33%), Positives = 148/295 (50%), Gaps = 4/295 (1%)
Frame = +1
Query: 172 YRERQMVSHLGDKYVFIAGCDSGFGNLLARQLDVRGLRVLAACLTEQG--AQQLRKQTSD 345
Y Q + + K V + G D G G+ L + LD G V A L E G A++LR+ S
Sbjct: 71 YLSGQELLPVDQKAVLVTGGDCGLGHALCKYLDELGFTVFAGVLNENGPGAEELRRTCSP 130
Query: 346 RLETVLLDVTKTESIAAATQWVKERVGDRGLWGLVNNAGTFHPLCITEWLKTETWIHTLK 525
RL + +D+TK I A V + DRGLW ++NNAG E L + +
Sbjct: 131 RLSVLQMDITKPVQIKDAYSKVAAMLQDRGLWAVINNAGVLGFPTDGELLLMTDYKQCMA 190
Query: 526 VNLIGVTEVTLSMLPLVKKAQGRIVNVSSILGRVAFFG-AVYSSSKHGVEAFSDVLRCEL 702
VN G EVT + LPL++K++GR+VNVSS+ G A Y SSK V FS V+R EL
Sbjct: 191 VNFFGTVEVTKTFLPLLRKSKGRLVNVSSMGGGAPMERLASYGSSKAAVTMFSSVMRLEL 250
Query: 703 QHFGVKVSIVEPGYFRTGMTDVQKSSEAM-KQVWKEVPAHIKDTYGQKFFDAYHDVMKQG 879
+G+KV+ ++PG F T + E + K + +PA +++ YGQ + A + +
Sbjct: 251 SKWGIKVASIQPGGFLTNIAGTSDKWEKLEKDILDHLPAEVQEDYGQDYILAQRNFLLLI 310
Query: 880 LSSCSTNLNLVTDCMEHALTSVHPRTRYSAGWDAQFFFIPLSYLPTSLADYILTR 1044
S S + + V ++HA+ + P Y+ G A + YLP + DY R
Sbjct: 311 NSLASKDFSPVLRDIQHAILAKSPFAYYTPGKGAYLWICLAHYLPIGIYDYFAKR 365
Database: RefSeqHP
Posted date: Aug 2, 2006 12:57 AM
Number of letters in database: 17,774,539
Number of sequences in database: 39,411
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 52,745,118
Number of Sequences: 39411
Number of extensions: 1319181
Number of successful extensions: 5079
Number of sequences better than 1.0e-05: 10
Number of HSP's better than 0.0 without gapping: 3833
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5035
length of database: 17,774,539
effective HSP length: 106
effective length of database: 13,596,973
effective search space used: 5153252767
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
Search to RefSeqSP
BLASTX 2.2.10 [Oct-19-2004]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= LVRM1_0096_C03
(1457 letters)
Database: RefSeqSP
1040 sequences; 434,620 total letters
Searching...done
Score E
Sequences producing significant alignments: (bits) Value
Alignment gi|NP_999078.1| hydroxysteroid 11-beta dehydrogenase 2 [Sus scr... 162 2e-41
Alignment gi|NP_998992.1| carbonyl reductase [Sus scrofa] 49 3e-07
Alignment gi|NP_999238.1| 20-beta-hydroxysteroid dehydrogenase [Sus scrofa] 49 4e-07
Alignment gi|NP_999413.1| 11-beta hydroxysteroid dehydrogenase isoform 1 ... 45 6e-06
>ref|NP_999078.1| hydroxysteroid 11-beta dehydrogenase 2 [Sus scrofa]
Length = 400
Score = 162 bits (409), Expect = 2e-41
Identities = 99/274 (36%), Positives = 143/274 (52%), Gaps = 4/274 (1%)
Frame = +1
Query: 214 VFIAGCDSGFGNLLARQLDVRGLRVLAACLT--EQGAQQLRKQTSDRLETVLLDVTKTES 387
V I GCDSGFG A++LD G VLA L GAQ+LR S RL+ + +D+TK
Sbjct: 85 VLITGCDSGFGKATAKKLDAMGFTVLATVLELDSPGAQELRACCSPRLKLLQMDLTKPAD 144
Query: 388 IAAATQWVKERVGDRGLWGLVNNAGTFHPLCITEWLKTETWIHTLKVNLIGVTEVTLSML 567
I+ ++ K GLWGLVNNAG + E T+ ++VN G E+T ++L
Sbjct: 145 ISRVLEFTKVHTASTGLWGLVNNAGHNILVADAELSPVATYRSCMEVNFFGTLEMTKALL 204
Query: 568 PLVKKAQGRIVNVSSILGRVAF-FGAVYSSSKHGVEAFSDVLRCELQHFGVKVSIVEPGY 744
PL++++ GRIV VSS G + F + Y +SK V D CELQ +GVKVS+++P
Sbjct: 205 PLLRRSSGRIVTVSSPAGDMPFPCLSAYGTSKAAVALLMDSFSCELQPWGVKVSVIQPAC 264
Query: 745 FRT-GMTDVQKSSEAMKQVWKEVPAHIKDTYGQKFFDAYHDVMKQGLSSCSTNLNLVTDC 921
FRT + +V + E +Q+ +P + YG+ + + + LS +L+ V D
Sbjct: 265 FRTEAVKNVDQWEERKRQLLATLPQELLQAYGEDYIEHLNGQFLHSLSQGLPDLSPVVDA 324
Query: 922 MEHALTSVHPRTRYSAGWDAQFFFIPLSYLPTSL 1023
+ AL + PR RY G + YLP L
Sbjct: 325 ITDALLAAKPRHRYYPGHGLGLMYFIHYYLPEGL 358
>ref|NP_998992.1| carbonyl reductase [Sus scrofa]
Length = 244
Score = 48.9 bits (115), Expect = 3e-07
Identities = 57/199 (28%), Positives = 85/199 (42%), Gaps = 3/199 (1%)
Frame = +1
Query: 220 IAGCDSGFGNLLARQLDVRGLRVLAACLTEQGAQQLRKQTSDRLETVLLDVTKTESIAAA 399
+ G G G + L V G RV+A T L Q +E V +D+ E A
Sbjct: 12 VTGAGKGIGRDTVKALHVSGARVVAVTRTNGDLVSL-SQECPGIEPVCVDLGDWE----A 66
Query: 400 TQWVKERVGDRGLWGLVNNAGTFHPLCITEWLKTETWIHTLKVNLIGVTEVT--LSMLPL 573
T+ VG L LVNNA + K E + + VNL V +V+ ++ +
Sbjct: 67 TERALGGVGPVDL--LVNNAAVALMQPFLDTTK-EVFDRSFNVNLRSVFQVSQIVARSMI 123
Query: 574 VKKAQGRIVNVSSILGRVAFFG-AVYSSSKHGVEAFSDVLRCELQHFGVKVSIVEPGYFR 750
+ G IVNVSS++ V + G A YSS+K + + + EL ++V+ V P
Sbjct: 124 ERGVPGSIVNVSSMVSHVTYPGLAAYSSTKGAMTMLTKSMAMELGPHKIRVNSVNPTVVL 183
Query: 751 TGMTDVQKSSEAMKQVWKE 807
T M S + + KE
Sbjct: 184 TAMGRSVTSDPELARKLKE 202
>ref|NP_999238.1| 20-beta-hydroxysteroid dehydrogenase [Sus scrofa]
Length = 289
Score = 48.5 bits (114), Expect = 4e-07
Identities = 46/147 (31%), Positives = 67/147 (45%), Gaps = 9/147 (6%)
Frame = +1
Query: 208 KYVFIAGCDSGFGNLLARQL--DVRGLRVLAACLTEQGAQQLRKQTSDRLETVL--LDVT 375
+ + G + G G + R L G VL A +G +++ ++ L LD+
Sbjct: 6 RVALVTGANKGIGFAIVRDLCRQFAGDVVLTARDVARGQAAVKQLQAEGLSPRFHQLDII 65
Query: 376 KTESIAAATQWVKERVGDRGLWGLVNNAGTFHPLCITEWLKTETWIH-----TLKVNLIG 540
+SI A ++++ G GL LVNNA I L T H T+K N +G
Sbjct: 66 DLQSIRALCDFLRKEYG--GLDVLVNNAA------IAFQLDNPTPFHIQAELTMKTNFMG 117
Query: 541 VTEVTLSMLPLVKKAQGRIVNVSSILG 621
V +LPL+ K QGR+VNVSS G
Sbjct: 118 TRNVCTELLPLI-KPQGRVVNVSSTEG 143
>ref|NP_999413.1| 11-beta hydroxysteroid dehydrogenase isoform 1 [Sus scrofa]
Length = 292
Score = 44.7 bits (104), Expect = 6e-06
Identities = 52/188 (27%), Positives = 87/188 (46%), Gaps = 11/188 (5%)
Frame = +1
Query: 199 LGDKYVFIAGCDSGFGNLLARQLDVRGLRVLAACLTEQGAQQLRKQTSDRLETVLLDVTK 378
L K V + G G G +A L G V+ +T + + L+K S LE L +
Sbjct: 32 LRGKKVIVTGASKGIGREMAYHLARMGAHVV---VTARSEETLKKVVSHSLE---LGASS 85
Query: 379 TESIAAATQ---WVKERVGDRG-LWGLVNNAGTFHPLCITEWLKTETW--IH----TLKV 528
+A + + ++ V G L G ++ H IT+ T + IH +++V
Sbjct: 86 AHYVAGTMEDMTFAEQFVAKAGKLLGGLDMLILNH---ITQAFMTSVYDDIHLVRRSMEV 142
Query: 529 NLIGVTEVTLSMLPLVKKAQGRIVNVSSILGRVAF-FGAVYSSSKHGVEAFSDVLRCELQ 705
N + ++++ LP++K++ G IV VSS G++A A YS+SK ++ F + E
Sbjct: 143 NFLSYVVLSVAALPMLKQSNGSIVVVSSQAGKMANPLVAPYSASKFALDGFFSSITKEYS 202
Query: 706 HFGVKVSI 729
V VSI
Sbjct: 203 VTKVNVSI 210
Database: RefSeqSP
Posted date: Aug 1, 2006 7:14 PM
Number of letters in database: 434,620
Number of sequences in database: 1040
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 1,289,370
Number of Sequences: 1040
Number of extensions: 31373
Number of successful extensions: 129
Number of sequences better than 1.0e-05: 4
Number of HSP's better than 0.0 without gapping: 100
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 126
length of database: 434,620
effective HSP length: 80
effective length of database: 351,420
effective search space used: 142325100
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
Search to RefSeqMP
BLASTX 2.2.10 [Oct-19-2004]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= LVRM1_0096_C03
(1457 letters)
Database: RefSeqMP
45,328 sequences; 21,768,885 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
Alignment gi|NP_038814.1| hydroxysteroid (17-beta) dehydrogenase 9 [Mus m... 443 e-124
Alignment gi|NP_059501.1| retinol dehydrogenase 7 [Mus musculus] 391 e-108
Alignment gi|NP_536684.1| retinol dehydrogenase 1 (all trans) [Mus musculus] 386 e-107
Alignment gi|NP_671755.1| retinol dehydrogenase similar protein 2 [Mus mu... 383 e-106
Alignment gi|NP_694773.1| retinol dehydrogenase 9 [Mus musculus] 382 e-106
Alignment gi|NP_033066.1| retinol dehydrogenase 16 [Mus musculus] 380 e-105
Alignment gi|NP_663399.1| cis-retinol/3alpha hydroxysterol short-chain de... 374 e-103
Alignment gi|NP_081577.1| retinol dehydrogenase similar protein [Mus musc... 314 2e-85
Alignment gi|NP_780721.1| NADP-dependent retinol dehydrogenase/reductase ... 301 2e-81
Alignment gi|NP_598767.1| retinol dehydrogenase 5 [Mus musculus] 289 5e-78
>ref|NP_038814.1| hydroxysteroid (17-beta) dehydrogenase 9 [Mus musculus]
Length = 317
Score = 443 bits (1140), Expect = e-124
Identities = 219/316 (69%), Positives = 250/316 (79%)
Frame = +1
Query: 121 MWXXXXXXXXXXXXXRWYRERQMVSHLGDKYVFIAGCDSGFGNLLARQLDVRGLRVLAAC 300
MW RWYRERQ+VSHL DKYVFI GCDSGFGNLLARQLD RG+RVLAAC
Sbjct: 1 MWFYLVTLVGLYHLLRWYRERQVVSHLQDKYVFITGCDSGFGNLLARQLDRRGMRVLAAC 60
Query: 301 LTEQGAQQLRKQTSDRLETVLLDVTKTESIAAATQWVKERVGDRGLWGLVNNAGTFHPLC 480
LTE+GA++LR +TSDRLETV+LDVTKTESI AATQWVKERVGDRGLWGLVNNAG P
Sbjct: 61 LTEKGAEELRNKTSDRLETVILDVTKTESIVAATQWVKERVGDRGLWGLVNNAGVLQPFA 120
Query: 481 ITEWLKTETWIHTLKVNLIGVTEVTLSMLPLVKKAQGRIVNVSSILGRVAFFGAVYSSSK 660
EW + E ++ +VNLIG+T+VT+SML LVKKA+GRIVNVSS LGRVA FG YS SK
Sbjct: 121 YIEWYRPEDYMPIFQVNLIGLTQVTISMLFLVKKARGRIVNVSSALGRVALFGGFYSCSK 180
Query: 661 HGVEAFSDVLRCELQHFGVKVSIVEPGYFRTGMTDVQKSSEAMKQVWKEVPAHIKDTYGQ 840
+GVEAFSDVLR E+Q FGVKVSI+EPG F+T MTD + + E K+VW+ P HIK++YGQ
Sbjct: 181 YGVEAFSDVLRHEVQDFGVKVSIIEPGSFKTEMTDAELTIERTKKVWEAAPEHIKESYGQ 240
Query: 841 KFFDAYHDVMKQGLSSCSTNLNLVTDCMEHALTSVHPRTRYSAGWDAQFFFIPLSYLPTS 1020
+FFD + K+ L CS NL+LVTDCMEHALTS HPRTRYSAGWDA+FFFIPLSYLP S
Sbjct: 241 QFFDDFCSTTKRELMKCSRNLSLVTDCMEHALTSTHPRTRYSAGWDAKFFFIPLSYLPAS 300
Query: 1021 LADYILTRSWPKPVQA 1068
L DY+L S KP QA
Sbjct: 301 LVDYLLAISRGKPAQA 316
>ref|NP_059501.1| retinol dehydrogenase 7 [Mus musculus]
Length = 316
Score = 391 bits (1004), Expect = e-108
Identities = 192/317 (60%), Positives = 245/317 (77%)
Frame = +1
Query: 121 MWXXXXXXXXXXXXXRWYRERQMVSHLGDKYVFIAGCDSGFGNLLARQLDVRGLRVLAAC 300
MW R++RERQ+VSHL DKYVFI GCDSGFGNLLARQLD RG+RVLAAC
Sbjct: 1 MWLYLVALVGLWTLLRFFRERQVVSHLQDKYVFITGCDSGFGNLLARQLDRRGMRVLAAC 60
Query: 301 LTEQGAQQLRKQTSDRLETVLLDVTKTESIAAATQWVKERVGDRGLWGLVNNAGTFHPLC 480
LTE+GA+QLR +TSDRLETV+LDVTKTESI AATQWVKERVG+RGLWGLVNNAG
Sbjct: 61 LTEKGAEQLRNKTSDRLETVILDVTKTESIVAATQWVKERVGNRGLWGLVNNAGIC-VFA 119
Query: 481 ITEWLKTETWIHTLKVNLIGVTEVTLSMLPLVKKAQGRIVNVSSILGRVAFFGAVYSSSK 660
I EWLK E + + L VNL+G+ EVTLSMLPLV+KA+GR+VN+SS +GRV+ G Y SK
Sbjct: 120 INEWLKKEDFANILDVNLLGMIEVTLSMLPLVRKARGRVVNISSSMGRVSLCGGGYCISK 179
Query: 661 HGVEAFSDVLRCELQHFGVKVSIVEPGYFRTGMTDVQKSSEAMKQVWKEVPAHIKDTYGQ 840
+GVEAFSD LR E+ +FGVKV+I+EPG FRT +++ ++ S +++++W + + +K+ Y +
Sbjct: 180 YGVEAFSDSLRREISYFGVKVAIIEPGGFRTNVSNYERLSHSIEKLWDQTSSEVKEVYDK 239
Query: 841 KFFDAYHDVMKQGLSSCSTNLNLVTDCMEHALTSVHPRTRYSAGWDAQFFFIPLSYLPTS 1020
F D+Y ++ +CS +L++VTDCMEHALT+ HPRTRYSAGWDA+ F++PLSY+PT
Sbjct: 240 NFLDSYIKAIQSLTDTCSDDLSVVTDCMEHALTACHPRTRYSAGWDAKLFYLPLSYMPTF 299
Query: 1021 LADYILTRSWPKPVQAV 1071
L D +L S KP QA+
Sbjct: 300 LVDAMLYWSSVKPAQAL 316
>ref|NP_536684.1| retinol dehydrogenase 1 (all trans) [Mus musculus]
Length = 317
Score = 386 bits (991), Expect = e-107
Identities = 192/317 (60%), Positives = 240/317 (75%)
Frame = +1
Query: 121 MWXXXXXXXXXXXXXRWYRERQMVSHLGDKYVFIAGCDSGFGNLLARQLDVRGLRVLAAC 300
MW R++RERQ+VSHL KYVFI GCDSGFGNLLARQLD RG+RVLAAC
Sbjct: 1 MWLYLVALVGLWTLLRFFRERQVVSHLQVKYVFITGCDSGFGNLLARQLDRRGMRVLAAC 60
Query: 301 LTEQGAQQLRKQTSDRLETVLLDVTKTESIAAATQWVKERVGDRGLWGLVNNAGTFHPLC 480
LTE+GA++LR +TSDRLETV+LDVTKTESI AATQWVKERVG+RGLWGLVNNAG P
Sbjct: 61 LTEKGAEELRNKTSDRLETVILDVTKTESIVAATQWVKERVGNRGLWGLVNNAGISTPSG 120
Query: 481 ITEWLKTETWIHTLKVNLIGVTEVTLSMLPLVKKAQGRIVNVSSILGRVAFFGAVYSSSK 660
EW+K + + L VNL+G+ EVTLSMLPLV+KA+GR+VNVSS++GR++FFG Y SK
Sbjct: 121 PNEWMKKQDFARVLDVNLLGMIEVTLSMLPLVRKARGRVVNVSSVMGRMSFFGGGYCISK 180
Query: 661 HGVEAFSDVLRCELQHFGVKVSIVEPGYFRTGMTDVQKSSEAMKQVWKEVPAHIKDTYGQ 840
+GVEAFSD LR EL +FGVKV+I+EPG F+T +T + S K +W + + +K+ YG+
Sbjct: 181 YGVEAFSDSLRRELSYFGVKVAIIEPGGFKTCVTSSDRLSSNTKMIWDKASSEVKEIYGE 240
Query: 841 KFFDAYHDVMKQGLSSCSTNLNLVTDCMEHALTSVHPRTRYSAGWDAQFFFIPLSYLPTS 1020
KF Y + + C+ +L++VTDCMEHALT+ HPRTRYSAGWDA+F F+PLSYLPT
Sbjct: 241 KFLLFYLKNLNELDKRCNKDLSVVTDCMEHALTARHPRTRYSAGWDAKFLFLPLSYLPTF 300
Query: 1021 LADYILTRSWPKPVQAV 1071
L D +L + KP +A+
Sbjct: 301 LVDALLYWTSMKPEKAL 317
>ref|NP_671755.1| retinol dehydrogenase similar protein 2 [Mus musculus]
Length = 318
Score = 383 bits (983), Expect = e-106
Identities = 191/318 (60%), Positives = 240/318 (75%), Gaps = 1/318 (0%)
Frame = +1
Query: 121 MWXXXXXXXXXXXXXRWYRERQMVSHLGDKYVFIAGCDSGFGNLLARQLDVRGLRVLAAC 300
MW R++RERQ+VSHL DKYVFI GCDSGFGNLLARQLD RG+RVLAAC
Sbjct: 1 MWLYLVPLVGLWTLLRFFRERQVVSHLQDKYVFITGCDSGFGNLLARQLDRRGMRVLAAC 60
Query: 301 LTEQGAQQLRKQTSDRLETVLLDVTKTESIAAATQWVKERVGDRGLWGLVNNAGTFHPLC 480
LTE+GA++LR +TSDRLETV+LDVTKTESI AATQWVKERVG+RGLWGLVNNAG PL
Sbjct: 61 LTEKGAEELRNKTSDRLETVILDVTKTESIVAATQWVKERVGNRGLWGLVNNAGISVPLG 120
Query: 481 ITEWLKTETWIHTLKVNLIGVTEVTLSMLPLVKKAQGRIVNVSSILGRVAFFG-AVYSSS 657
+++W+ + + L VNL+G+ EVTL+MLPLV+KA+GR+VNVSSI+GRV+ G Y S
Sbjct: 121 LSQWMNKQNFASVLDVNLLGMIEVTLTMLPLVRKARGRVVNVSSIMGRVSLHGNGGYCIS 180
Query: 658 KHGVEAFSDVLRCELQHFGVKVSIVEPGYFRTGMTDVQKSSEAMKQVWKEVPAHIKDTYG 837
K+GVEAFSD LR EL +FGVKV+I+EPG+F TGM + S + +W + + I++ YG
Sbjct: 181 KYGVEAFSDSLRRELSYFGVKVAIIEPGFFLTGMASSARLSSNTQMLWDQTSSEIREIYG 240
Query: 838 QKFFDAYHDVMKQGLSSCSTNLNLVTDCMEHALTSVHPRTRYSAGWDAQFFFIPLSYLPT 1017
+K+ Y + + C+ +L+LVTDCMEHALT+ HPRTRYSAGWDA+ FFIPLSYLPT
Sbjct: 241 EKYLAFYLKSLNELDKRCNKDLSLVTDCMEHALTACHPRTRYSAGWDAKLFFIPLSYLPT 300
Query: 1018 SLADYILTRSWPKPVQAV 1071
L D + + KP +A+
Sbjct: 301 FLVDAVFYWTSMKPEKAL 318
>ref|NP_694773.1| retinol dehydrogenase 9 [Mus musculus]
Length = 317
Score = 382 bits (980), Expect = e-106
Identities = 187/317 (58%), Positives = 239/317 (75%)
Frame = +1
Query: 121 MWXXXXXXXXXXXXXRWYRERQMVSHLGDKYVFIAGCDSGFGNLLARQLDVRGLRVLAAC 300
MW ++RERQ+VS+L DKYVFI GCDSGFGNLLARQLD RG+RVLAAC
Sbjct: 1 MWLFLVALVGLWTLLCFFRERQVVSYLQDKYVFITGCDSGFGNLLARQLDRRGMRVLAAC 60
Query: 301 LTEQGAQQLRKQTSDRLETVLLDVTKTESIAAATQWVKERVGDRGLWGLVNNAGTFHPLC 480
LTE+GA++LR +TSDRLETV+LDVTKTESI ATQWVKERVG+RGLWGLVNNAG P
Sbjct: 61 LTEKGAEELRNKTSDRLETVILDVTKTESIVTATQWVKERVGNRGLWGLVNNAGISIPSG 120
Query: 481 ITEWLKTETWIHTLKVNLIGVTEVTLSMLPLVKKAQGRIVNVSSILGRVAFFGAVYSSSK 660
EW+K + + H L VNL+G+ EVTLSMLPLV+KA+GR++NV+S+LGRV+ G Y SK
Sbjct: 121 PNEWMKKQDFAHVLDVNLLGLIEVTLSMLPLVRKARGRVINVASVLGRVSLCGGAYCISK 180
Query: 661 HGVEAFSDVLRCELQHFGVKVSIVEPGYFRTGMTDVQKSSEAMKQVWKEVPAHIKDTYGQ 840
+GVEAFSD LR EL +FGVKV+I+EPG+F TG+T + + +W + + I++ YG+
Sbjct: 181 YGVEAFSDSLRRELSYFGVKVAIIEPGFFLTGVTSSARLCSNTQMLWDQTSSEIREIYGE 240
Query: 841 KFFDAYHDVMKQGLSSCSTNLNLVTDCMEHALTSVHPRTRYSAGWDAQFFFIPLSYLPTS 1020
K+ +Y + + C+ +L+LVTDCMEHALT+ HPRTRYSAGWDA+ F++PLSYLPT
Sbjct: 241 KYLASYLKRLNELDKRCNKDLSLVTDCMEHALTACHPRTRYSAGWDAKLFYLPLSYLPTF 300
Query: 1021 LADYILTRSWPKPVQAV 1071
L D +L + KP +A+
Sbjct: 301 LVDALLYWTSLKPEKAL 317
>ref|NP_033066.1| retinol dehydrogenase 16 [Mus musculus]
Length = 317
Score = 380 bits (975), Expect = e-105
Identities = 187/317 (58%), Positives = 237/317 (74%)
Frame = +1
Query: 121 MWXXXXXXXXXXXXXRWYRERQMVSHLGDKYVFIAGCDSGFGNLLARQLDVRGLRVLAAC 300
MW R++R RQ+VSHL DKYVFI GCDSGFG LLARQLD RG+RVLAAC
Sbjct: 1 MWLYLVALVGLWTLLRFFRVRQVVSHLQDKYVFITGCDSGFGTLLARQLDRRGMRVLAAC 60
Query: 301 LTEQGAQQLRKQTSDRLETVLLDVTKTESIAAATQWVKERVGDRGLWGLVNNAGTFHPLC 480
LTE+GA++LR +TSDRLETV+LDVTKTESI ATQWVKE VG+RGLWGLVNNAG P
Sbjct: 61 LTEKGAEELRNKTSDRLETVILDVTKTESIVTATQWVKEHVGNRGLWGLVNNAGISTPSG 120
Query: 481 ITEWLKTETWIHTLKVNLIGVTEVTLSMLPLVKKAQGRIVNVSSILGRVAFFGAVYSSSK 660
EW+K + + H L VNL+G+ EVTLSMLPLV+KA+GR+VNVSS++GRV+ FG Y SK
Sbjct: 121 PNEWMKKQDFAHVLDVNLLGMIEVTLSMLPLVRKARGRVVNVSSVMGRVSLFGGGYCISK 180
Query: 661 HGVEAFSDVLRCELQHFGVKVSIVEPGYFRTGMTDVQKSSEAMKQVWKEVPAHIKDTYGQ 840
+GVEAFSD LR EL +FGVKV+I+EPG+F TG+T + + +W + + I++ YG+
Sbjct: 181 YGVEAFSDSLRRELSYFGVKVAIIEPGFFLTGVTSSARLCSNTQMLWDQTSSEIREIYGE 240
Query: 841 KFFDAYHDVMKQGLSSCSTNLNLVTDCMEHALTSVHPRTRYSAGWDAQFFFIPLSYLPTS 1020
K+ +Y + + C+ +L+ VTDCMEHALT+ HPRTRYSAGWDA+ F++PLSYLPT
Sbjct: 241 KYLASYLKRLNKLDKRCNKDLSGVTDCMEHALTACHPRTRYSAGWDAKLFYLPLSYLPTF 300
Query: 1021 LADYILTRSWPKPVQAV 1071
L D +L + KP +A+
Sbjct: 301 LVDALLYWTSLKPEKAL 317
>ref|NP_663399.1| cis-retinol/3alpha hydroxysterol short-chain dehydrogenase-like [Mus
musculus]
Length = 318
Score = 374 bits (961), Expect = e-103
Identities = 187/318 (58%), Positives = 239/318 (75%), Gaps = 1/318 (0%)
Frame = +1
Query: 121 MWXXXXXXXXXXXXXRWYRERQMVSHLGDKYVFIAGCDSGFGNLLARQLDVRGLRVLAAC 300
MW R++RERQ+V HL DKYVFI GC SGFGNLLARQLD RG+RVLAAC
Sbjct: 1 MWLYMVALLGLWMLLRFFRERQVVDHLQDKYVFITGCGSGFGNLLARQLDRRGMRVLAAC 60
Query: 301 LTEQGAQQLRKQTSDRLETVLLDVTKTESIAAATQWVKERVGDRGLWGLVNNAGTFHPLC 480
E+GA++LR++TS+RLETV+LDVTKTESI AATQWVKERVG+RGLWGLVNNAG P
Sbjct: 61 RKEEGAEELRRKTSERLETVILDVTKTESIVAATQWVKERVGNRGLWGLVNNAGISVPSG 120
Query: 481 ITEWLKTETWIHTLKVNLIGVTEVTLSMLPLVKKAQGRIVNVSSILGRVAFFGA-VYSSS 657
EW+K + + L VNL+G+ EVTLSMLPLV+KA+GR+VNVSSILGRV+ G+ Y S
Sbjct: 121 PNEWMKKQDFASVLDVNLLGLIEVTLSMLPLVRKARGRVVNVSSILGRVSLGGSGGYCIS 180
Query: 658 KHGVEAFSDVLRCELQHFGVKVSIVEPGYFRTGMTDVQKSSEAMKQVWKEVPAHIKDTYG 837
K+G+EAFSD LR EL++FGVKV+I+EPG+F TGM + ++ +W + + I++ YG
Sbjct: 181 KYGIEAFSDSLRRELRYFGVKVAIIEPGFFLTGMASSARLCSNIQMLWDQTSSEIREIYG 240
Query: 838 QKFFDAYHDVMKQGLSSCSTNLNLVTDCMEHALTSVHPRTRYSAGWDAQFFFIPLSYLPT 1017
+K+ +Y + + C+ +L++VTDCMEHALT+ HPRTRYSAGWDA+ FF PLSYLPT
Sbjct: 241 EKYLASYLKNLNELDQRCNKDLSVVTDCMEHALTACHPRTRYSAGWDAKLFFTPLSYLPT 300
Query: 1018 SLADYILTRSWPKPVQAV 1071
L D +L + PKP +A+
Sbjct: 301 FLVDALLYWTSPKPDKAL 318
>ref|NP_081577.1| retinol dehydrogenase similar protein [Mus musculus]
Length = 313
Score = 314 bits (804), Expect = 2e-85
Identities = 149/302 (49%), Positives = 214/302 (70%)
Frame = +1
Query: 166 RWYRERQMVSHLGDKYVFIAGCDSGFGNLLARQLDVRGLRVLAACLTEQGAQQLRKQTSD 345
RW++ +V +L +KYVFI GCDSGFGNLLA+QL RG++VLAACLTE+GAQ+L + TS
Sbjct: 12 RWFKNCNLVKNLSEKYVFITGCDSGFGNLLAKQLVDRGMKVLAACLTEEGAQKLLQDTSH 71
Query: 346 RLETVLLDVTKTESIAAATQWVKERVGDRGLWGLVNNAGTFHPLCITEWLKTETWIHTLK 525
+L+T LLDVTK+E++ A QWV+++VG++GLW LVNNAG P EWL + ++ +
Sbjct: 72 QLQTFLLDVTKSENVKEAAQWVRDQVGEQGLWALVNNAGVGLPSGPNEWLTIKDFVKVIN 131
Query: 526 VNLIGVTEVTLSMLPLVKKAQGRIVNVSSILGRVAFFGAVYSSSKHGVEAFSDVLRCELQ 705
+NL+G+ +VTL+MLP++KKA+GR+VN+SS GRVA FG Y SK GVEAFSD +R EL
Sbjct: 132 INLVGLIDVTLNMLPMIKKARGRVVNMSSSGGRVAIFGGGYCVSKFGVEAFSDSIRRELH 191
Query: 706 HFGVKVSIVEPGYFRTGMTDVQKSSEAMKQVWKEVPAHIKDTYGQKFFDAYHDVMKQGLS 885
FGVKVSI+EPG ++T + + MK++W +P +D+YG+++F Y + +
Sbjct: 192 FFGVKVSIIEPGNYKTSILGQEALESRMKKLWDRLPQETRDSYGEEYFQTYTKKLVNLMR 251
Query: 886 SCSTNLNLVTDCMEHALTSVHPRTRYSAGWDAQFFFIPLSYLPTSLADYILTRSWPKPVQ 1065
S ++ VT+ MEHA+ S PR RY+ G D +F ++ L+ LPT + D+IL+R P+P
Sbjct: 252 SAEPRISDVTNSMEHAIVSRSPRIRYNPGLDVKFLYLTLAKLPTPVTDFILSRYLPRPAD 311
Query: 1066 AV 1071
+V
Sbjct: 312 SV 313
>ref|NP_780721.1| NADP-dependent retinol dehydrogenase/reductase [Mus musculus]
Length = 319
Score = 301 bits (770), Expect = 2e-81
Identities = 145/291 (49%), Positives = 203/291 (69%)
Frame = +1
Query: 172 YRERQMVSHLGDKYVFIAGCDSGFGNLLARQLDVRGLRVLAACLTEQGAQQLRKQTSDRL 351
Y+ + ++ + DKYVFI GCD+GFGNL AR D +G RV+AACLTE G+ L+ +TS+RL
Sbjct: 18 YKGQLKIADIADKYVFITGCDTGFGNLAARTFDKKGFRVIAACLTESGSAALKAKTSERL 77
Query: 352 ETVLLDVTKTESIAAATQWVKERVGDRGLWGLVNNAGTFHPLCITEWLKTETWIHTLKVN 531
TVLLDVT E++ QWVK VG++GLWGL+NNAG L T+WL + + ++VN
Sbjct: 78 HTVLLDVTDPENVKKTAQWVKSHVGEKGLWGLINNAGVLGVLAPTDWLTVDDYREPIEVN 137
Query: 532 LIGVTEVTLSMLPLVKKAQGRIVNVSSILGRVAFFGAVYSSSKHGVEAFSDVLRCELQHF 711
L G+ VTL+MLPLVKKA+GR++NVSSI GR+AF G Y+ SK+ VE F+D LR +++ F
Sbjct: 138 LFGLINVTLNMLPLVKKARGRVINVSSIGGRLAFGGGGYTPSKYAVEGFNDSLRRDMKAF 197
Query: 712 GVKVSIVEPGYFRTGMTDVQKSSEAMKQVWKEVPAHIKDTYGQKFFDAYHDVMKQGLSSC 891
GV VS +EPG F+T + D K++E +WK + IK YG+ + + +K SS
Sbjct: 198 GVHVSCIEPGLFKTELADPIKTTEKKLAIWKHLSPDIKQQYGEGYIEKSLHRLKSNTSSV 257
Query: 892 STNLNLVTDCMEHALTSVHPRTRYSAGWDAQFFFIPLSYLPTSLADYILTR 1044
+ +L+LV CM+HALTS+ P+TRY AG DA+ F+IPLS++P L D++L +
Sbjct: 258 NLDLSLVVGCMDHALTSLFPKTRYIAGKDAKTFWIPLSHMPAVLQDFLLLK 308
>ref|NP_598767.1| retinol dehydrogenase 5 [Mus musculus]
Length = 318
Score = 289 bits (740), Expect = 5e-78
Identities = 144/300 (48%), Positives = 201/300 (67%), Gaps = 1/300 (0%)
Frame = +1
Query: 175 RERQMVSHLGDKYVFIAGCDSGFGNLLARQLDVRGLRVLAACLTEQGAQQLRKQTSDRLE 354
R+RQ + D ++FI GCDSGFG LLA QLD +G +VLA CLT GA+ L++ S RL
Sbjct: 19 RDRQSLP-ASDAFIFITGCDSGFGRLLALQLDQKGFQVLAGCLTPSGAEDLQQMASSRLH 77
Query: 355 TVLLDVTKTESIAAATQWVKERVGDRGLWGLVNNAGTFHPLCITEWLKTETWIHTLKVNL 534
T LLD+T +++ +WVK RVG+ GL+GLVNNAG + T WL + + L VN
Sbjct: 78 TTLLDITDPQNVQQVAKWVKTRVGETGLFGLVNNAGVAGIIGPTPWLTQDDFQRVLSVNT 137
Query: 535 IGVTEVTLSMLPLVKKAQGRIVNVSSILGRVAFFGAVYSSSKHGVEAFSDVLRCELQHFG 714
+G VTL++LPL+++A+GR+VN++S+LGR+A G Y SK G+EAFSD LR ++ FG
Sbjct: 138 LGPIGVTLALLPLLQQARGRVVNITSVLGRIAANGGGYCVSKFGLEAFSDSLRRDMAPFG 197
Query: 715 VKVSIVEPGYFRTGMTDVQKSSEAMKQVWKEVPAHIKDTYGQKFFDAYHDVMKQGLS-SC 891
V+VSIVEPG+FRT +T+++ +K W +P I+ YG+ F D Y V ++ ++ C
Sbjct: 198 VQVSIVEPGFFRTPVTNLESLESTLKACWARLPPAIQAHYGEAFLDTYLRVQRRIMNLIC 257
Query: 892 STNLNLVTDCMEHALTSVHPRTRYSAGWDAQFFFIPLSYLPTSLADYILTRSWPKPVQAV 1071
L VT C+EHALT+ HPRTRYS GWDA+ ++P SYLP + D +LT P+P Q+V
Sbjct: 258 DPELTKVTSCLEHALTARHPRTRYSPGWDAKLLWLPASYLPARVVDAVLTWILPRPAQSV 317
Database: RefSeqMP
Posted date: Aug 2, 2006 12:58 AM
Number of letters in database: 21,768,885
Number of sequences in database: 45,328
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 63,714,543
Number of Sequences: 45328
Number of extensions: 1566074
Number of successful extensions: 5463
Number of sequences better than 1.0e-05: 10
Number of HSP's better than 0.0 without gapping: 4360
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5421
length of database: 21,768,885
effective HSP length: 107
effective length of database: 16,918,789
effective search space used: 6395302242
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)