Animal-Genome cDNA LVRM1_0151_G04


Search to RefSeqBP

BLASTX 2.2.10 [Oct-19-2004]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= LVRM1_0151_G04
         (2212 letters)

Database: RefSeqBP 
           33,508 sequences; 16,112,626 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

Alignment   gi|XP_604169.2| PREDICTED: similar to malic enzyme 3, NADP(+)-d...   722   0.0  
Alignment   gi|XP_613987.2| PREDICTED: similar to NADP-dependent malic enzy...   610   e-174
Alignment   gi|XP_584500.2| PREDICTED: similar to NAD-dependent malic enzym...   504   e-142
Alignment   gi|XP_875137.1| PREDICTED: similar to NAD-dependent malic enzym...   163   6e-40
Alignment   gi|XP_596455.2| PREDICTED: similar to NADP-dependent malic enzy...   162   1e-39

>ref|XP_604169.2| PREDICTED: similar to malic enzyme 3, NADP(+)-dependent,
            mitochondrial [Bos taurus]
          Length = 564

 Score =  722 bits (1863), Expect = 0.0
 Identities = 353/498 (70%), Positives = 425/498 (85%)
 Frame = +3

Query: 219  LAFTLEERQQLNIHGLLPPCFISQDIQVLRVIKNFERLNSDFDRYLLLMDLQDRNEKLFY 398
            +AFTLEER QL IHGL+PPCF+SQD+Q+LRV++ +ER  SD D+Y++LM LQDRNEKLFY
Sbjct: 1    MAFTLEERLQLGIHGLIPPCFLSQDVQLLRVMRYYERQQSDLDKYIILMTLQDRNEKLFY 60

Query: 399  KVLMSDIEKFMPIVYTPTVGLACQQYSLAFRKPRGLFISIHDRGHVASVLNAWPEDVIKA 578
            +VL SD+EKF+PIVYTPTVGLACQ Y L FR+PRGLFI++HD+GH+A++LN+WPED IKA
Sbjct: 61   RVLTSDVEKFLPIVYTPTVGLACQHYGLTFRRPRGLFITVHDKGHLATMLNSWPEDDIKA 120

Query: 579  VVVTDGERILGLGDLGCNGMGIPVGKLALYTACGGVNPQECLPVILDVGTENEELLKDPL 758
            VVVTDGERILGLGDLGC GMGIPVGKLALYTACGGVNP++CLPV+LDVGT NEELL+DPL
Sbjct: 121  VVVTDGERILGLGDLGCYGMGIPVGKLALYTACGGVNPRQCLPVLLDVGTNNEELLRDPL 180

Query: 759  YIGLRQRRVRGPEYDDFLDEFMEAVSSKYGMNCLIQFEDFANINAFRLLKKYQNQYCTFN 938
            YIGL+ RRVRG EYDD LDEFM+AV+ K+G+NCLIQFEDFAN NAFRLL KY+N+YC FN
Sbjct: 181  YIGLKHRRVRGQEYDDLLDEFMQAVTDKFGINCLIQFEDFANANAFRLLNKYRNKYCMFN 240

Query: 939  DDIQGTASVAVAGILAALRITKNKLSDQTILFQGAGEAALGIAHLIVMAMEKEGVPKEKA 1118
            DDIQGTASVAVAGILAALRITKNKLS+   +FQGAGEAA+GIAHL+VMA+EKEG+ ++  
Sbjct: 241  DDIQGTASVAVAGILAALRITKNKLSNHVFVFQGAGEAAMGIAHLLVMALEKEGISRQ-- 298

Query: 1119 IKKIWLVDSKGLIVKGRAALTNXXXXXXXXXXXMKNLEAIVQDIKPTALIGVAAIGGAFS 1298
              + W+     L ++GR+ L +           + +LE +V+ +KPTA+IGVAAI GAF+
Sbjct: 299  --EYWMF---FLSLQGRSHLNHEKEMFAQDHPEVNSLEEVVRLVKPTAIIGVAAIAGAFT 353

Query: 1299 EQILKDMAAFNERPIIFALSNPTSKAECTAEQCYTLTQGRAIFASGSPFDPVTLPSGQTL 1478
            EQIL+DMA+F+E PIIFALSNPTSKAECTAE+CY +T+GR IFASGSPF  VTL  G+T 
Sbjct: 354  EQILRDMASFHEHPIIFALSNPTSKAECTAEKCYRVTEGRGIFASGSPFPSVTLEDGRTF 413

Query: 1479 YPGQGNNSYVFPGVALGVVACGLRHITDKILLTTAEVIAQQVSDKHLEEGRLYPPLNTIR 1658
            +PGQGNN+YVFPGVALGV+A G+RHI D+I L TAE IAQ+VS+ HL +GRLYPPL+TIR
Sbjct: 414  FPGQGNNAYVFPGVALGVIAGGIRHIPDEIFLLTAEQIAQEVSEHHLSQGRLYPPLSTIR 473

Query: 1659 DVSLKIAEKIVRDAYQEK 1712
            DVSL+IA K VRD+   K
Sbjct: 474  DVSLRIAIK-VRDSSPPK 490


>ref|XP_613987.2| PREDICTED: similar to NADP-dependent malic enzyme (NADP-ME) (Malic
            enzyme 1) [Bos taurus]
          Length = 472

 Score =  610 bits (1573), Expect = e-174
 Identities = 307/343 (89%), Positives = 322/343 (93%)
 Frame = +3

Query: 822  MEAVSSKYGMNCLIQFEDFANINAFRLLKKYQNQYCTFNDDIQGTASVAVAGILAALRIT 1001
            +  +S +YGMNCLIQFEDFANINAFRLL+KYQNQYCTFNDDIQGTASVAVAGILAALRIT
Sbjct: 130  VNVLSHRYGMNCLIQFEDFANINAFRLLRKYQNQYCTFNDDIQGTASVAVAGILAALRIT 189

Query: 1002 KNKLSDQTILFQGAGEAALGIAHLIVMAMEKEGVPKEKAIKKIWLVDSKGLIVKGRAALT 1181
            KNKLSDQT+LFQGAGEAALGIAHLIVMAMEKEG+ KE+AI+KIWLVDSKGLIVKGRAALT
Sbjct: 190  KNKLSDQTVLFQGAGEAALGIAHLIVMAMEKEGLSKEQAIEKIWLVDSKGLIVKGRAALT 249

Query: 1182 NXXXXXXXXXXXMKNLEAIVQDIKPTALIGVAAIGGAFSEQILKDMAAFNERPIIFALSN 1361
                        MKNLEAIVQDIKPTALIGVAAIGGAFSEQI+KDMAAFNERPIIFALSN
Sbjct: 250  QEKEEFAHEHKEMKNLEAIVQDIKPTALIGVAAIGGAFSEQIIKDMAAFNERPIIFALSN 309

Query: 1362 PTSKAECTAEQCYTLTQGRAIFASGSPFDPVTLPSGQTLYPGQGNNSYVFPGVALGVVAC 1541
            PTSKAECTAEQCY LT+GRAIFASGSPFDPVTLPSG+TLYPGQGNNSYVFPGVALGVVAC
Sbjct: 310  PTSKAECTAEQCYKLTKGRAIFASGSPFDPVTLPSGKTLYPGQGNNSYVFPGVALGVVAC 369

Query: 1542 GLRHITDKILLTTAEVIAQQVSDKHLEEGRLYPPLNTIRDVSLKIAEKIVRDAYQEKTAT 1721
            GLRHITDKI LTTAEVIAQQVSDKHLEEGRLYPPL+TIRDVSLKIAEKIV+DAYQEKTAT
Sbjct: 370  GLRHITDKIFLTTAEVIAQQVSDKHLEEGRLYPPLDTIRDVSLKIAEKIVKDAYQEKTAT 429

Query: 1722 IYPEPSNKEAFVRSQMYSTDYDQILPDGYSWPEEAQKIQTKLD 1850
            +YPEP NKEAFVRSQMYSTDYDQILPD Y WP+EAQKIQTKLD
Sbjct: 430  VYPEPPNKEAFVRSQMYSTDYDQILPDCYPWPKEAQKIQTKLD 472



 Score =  189 bits (481), Expect = 6e-48
 Identities = 95/109 (87%), Positives = 100/109 (91%), Gaps = 8/109 (7%)
 Frame = +3

Query: 216 DLAFTLEERQQLNIHGLLPPCFISQDIQVLRVIKNFERLNSDFDRYLLLMDLQDRNEKLF 395
           DLAFTLEERQQLNIHGLLPP FISQD+QVLRV+KNFERLNSDFDRYLLLMDLQDRNEKLF
Sbjct: 14  DLAFTLEERQQLNIHGLLPPSFISQDVQVLRVLKNFERLNSDFDRYLLLMDLQDRNEKLF 73

Query: 396 YKVLMSDIEKFMPIVYTPTVGLACQQYSLAFRKPR--------GLFISI 518
           YKVLMSDIEKFMPIVYTPTVGLACQQYSLAFRKPR        GLF+++
Sbjct: 74  YKVLMSDIEKFMPIVYTPTVGLACQQYSLAFRKPRFNVLVTSYGLFLNV 122


>ref|XP_584500.2| PREDICTED: similar to NAD-dependent malic enzyme, mitochondrial
            precursor (NAD-ME) (Malic enzyme 2), partial [Bos taurus]
          Length = 513

 Score =  504 bits (1297), Expect = e-142
 Identities = 249/424 (58%), Positives = 310/424 (73%), Gaps = 3/424 (0%)
 Frame = +3

Query: 150  APRRRHTLQRGYAVTRIPHLNKDLAFTLEERQQLNIHGLLPPCFISQDIQVLRVIKNFER 329
            A R  HT ++G  +   P  NK +AFTL+ERQ L + GLLPP   +QDIQ LR  +N ++
Sbjct: 90   ACRHLHTKEKGKPLMLNPRTNKGMAFTLQERQMLGLQGLLPPKIETQDIQALRFHRNLKK 149

Query: 330  LNSDFDRYLLLMDLQDRNEKLFYKVLMSDIEKFMPIVYTPTVGLACQQYSLAFRKPRGLF 509
            LN   ++Y+ +M +Q+RNEKLFY++L  DIE  MPIVYTPTVGLAC QY   FR+P+GLF
Sbjct: 150  LNGPLEKYIYIMGIQERNEKLFYRILQDDIETLMPIVYTPTVGLACSQYGHIFRRPKGLF 209

Query: 510  ISIHDRGHVASVLNAWPEDVIKAVVVTDGERILGLGDLGCNGMGIPVGKLALYTACGGVN 689
            ISI DRGHV S+++ WPE+ +KAVVVTDGERILGLGDLG  GMGIPVGKL LYTAC G+ 
Sbjct: 210  ISISDRGHVRSIVDNWPENHVKAVVVTDGERILGLGDLGVYGMGIPVGKLCLYTACAGIR 269

Query: 690  PQECLPVILDVGTENEELLKDPLYIGLRQRRVRGPEYDDFLDEFMEAVSSKYGMNCLIQF 869
            P  CLPV +DVGT+N  LLKDP Y+GL Q+R R   YDD +DEFM+A++ +YG N LIQF
Sbjct: 270  PDRCLPVCIDVGTDNPALLKDPFYMGLYQKRDRSQRYDDLIDEFMKAITDRYGQNTLIQF 329

Query: 870  EDFANINAFRLLKKYQNQYCTFNDDIQGTASVAVAGILAALRITKNKLSDQTILFQGAGE 1049
            EDF N NAFR L+KY+ +YCTFNDDIQGTA+VA+AG+LAA ++    +SD  ILF GAGE
Sbjct: 330  EDFGNHNAFRFLRKYREKYCTFNDDIQGTAAVALAGLLAAQKVIGKPISDHRILFLGAGE 389

Query: 1050 AALGIAHLIVMAMEKEGVPKEKAIKKIWLVDSKGLIVKGRAALTNX---XXXXXXXXXXM 1220
            AALGIA+LIVMAM + G+ +E+A KKIW+VD  GL+ KGR A                  
Sbjct: 390  AALGIANLIVMAMVENGLSEEEARKKIWMVDKFGLLFKGRKAKIESHQEAFAHSAPESLP 449

Query: 1221 KNLEAIVQDIKPTALIGVAAIGGAFSEQILKDMAAFNERPIIFALSNPTSKAECTAEQCY 1400
               E  V  +KP+A+IGVA  G  F+  ++K MA  NERPIIFALSNPT++AECTAE+ Y
Sbjct: 450  DTFEEAVNILKPSAIIGVAGAGRLFTPGVIKAMAEINERPIIFALSNPTAQAECTAEEAY 509

Query: 1401 TLTQ 1412
            TLT+
Sbjct: 510  TLTE 513


>ref|XP_875137.1| PREDICTED: similar to NAD-dependent malic enzyme, mitochondrial
            precursor (NAD-ME) (Malic enzyme 2), partial [Bos taurus]
          Length = 152

 Score =  163 bits (412), Expect = 6e-40
 Identities = 72/139 (51%), Positives = 97/139 (69%)
 Frame = +3

Query: 1410 QGRAIFASGSPFDPVTLPSGQTLYPGQGNNSYVFPGVALGVVACGLRHITDKILLTTAEV 1589
            QGR +FASGSPF+PV L  GQ   PGQGNN Y+FPGVAL V+ C  RHI+D + L  A+ 
Sbjct: 6    QGRCLFASGSPFEPVKLSDGQVFTPGQGNNVYIFPGVALAVILCNTRHISDHVFLEAAKA 65

Query: 1590 IAQQVSDKHLEEGRLYPPLNTIRDVSLKIAEKIVRDAYQEKTATIYPEPSNKEAFVRSQM 1769
            +  Q++DK L +GRLYPPL+ I++VS+ IA K+    Y  K A  YPEP +K  ++R ++
Sbjct: 66   LTSQLTDKELAQGRLYPPLSNIQEVSINIAIKVTEYLYANKMAFRYPEPEDKAKYIRERI 125

Query: 1770 YSTDYDQILPDGYSWPEEA 1826
            + ++YD +LPD Y WPE A
Sbjct: 126  WRSEYDSLLPDVYEWPEAA 144


>ref|XP_596455.2| PREDICTED: similar to NADP-dependent malic enzyme (NADP-ME) (Malic
           enzyme 1) [Bos taurus]
          Length = 157

 Score =  162 bits (410), Expect = 1e-39
 Identities = 74/80 (92%), Positives = 80/80 (100%)
 Frame = +3

Query: 498 RGLFISIHDRGHVASVLNAWPEDVIKAVVVTDGERILGLGDLGCNGMGIPVGKLALYTAC 677
           RGLFISIHDRGH++SVLNAWPEDVIKA+VVTDGERILGLGDLGCNGMGIPVGKLALYTAC
Sbjct: 72  RGLFISIHDRGHISSVLNAWPEDVIKAIVVTDGERILGLGDLGCNGMGIPVGKLALYTAC 131

Query: 678 GGVNPQECLPVILDVGTENE 737
           GG+NPQ+CLPV+LDVGTENE
Sbjct: 132 GGMNPQQCLPVMLDVGTENE 151


  Database: RefSeqBP
    Posted date:  Aug 1, 2006  7:14 PM
  Number of letters in database: 16,112,626
  Number of sequences in database:  33,508
  
Lambda     K      H
   0.318    0.134    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 67,461,018
Number of Sequences: 33508
Number of extensions: 1680811
Number of successful extensions: 4738
Number of sequences better than 1.0e-05: 5
Number of HSP's better than  0.0 without gapping: 4160
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4732
length of database: 16,112,626
effective HSP length: 109
effective length of database: 12,460,254
effective search space used: 7812579258
frameshift window, decay const: 40,  0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)

Search to RefSeqCP

BLASTX 2.2.10 [Oct-19-2004]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= LVRM1_0151_G04
         (2212 letters)

Database: RefSeqCP 
           33,732 sequences; 19,266,565 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

Alignment   gi|XP_532217.2| PREDICTED: similar to NADP-dependent malic enzy...  1014   0.0  
Alignment   gi|XP_848770.1| PREDICTED: similar to malic enzyme 3, NADP(+)-d...   840   0.0  
Alignment   gi|XP_542269.2| PREDICTED: similar to malic enzyme 3, NADP(+)-d...   804   0.0  
Alignment   gi|XP_857227.1| PREDICTED: similar to malic enzyme 3, NADP(+)-d...   801   0.0  
Alignment   gi|XP_857135.1| PREDICTED: similar to malic enzyme 3, NADP(+)-d...   798   0.0  
Alignment   gi|XP_857177.1| PREDICTED: similar to malic enzyme 3, NADP(+)-d...   746   0.0  
Alignment   gi|XP_849530.1| PREDICTED: similar to NAD-dependent malic enzym...   652   0.0  
Alignment   gi|XP_533402.2| PREDICTED: similar to NAD-dependent malic enzym...   594   e-169
Alignment   gi|XP_857051.1| PREDICTED: similar to malic enzyme 3, NADP(+)-d...   551   e-157
Alignment   gi|XP_857091.1| PREDICTED: similar to NADP-dependent malic enzy...   296   7e-80

>ref|XP_532217.2| PREDICTED: similar to NADP-dependent malic enzyme (NADP-ME) (Malic
            enzyme 1) [Canis familiaris]
          Length = 634

 Score = 1014 bits (2622), Expect = 0.0
 Identities = 505/546 (92%), Positives = 522/546 (95%)
 Frame = +3

Query: 213  KDLAFTLEERQQLNIHGLLPPCFISQDIQVLRVIKNFERLNSDFDRYLLLMDLQDRNEKL 392
            +DLAFTLEERQQLNIHGLLPPCFISQDIQVLR+IKNFERL SDFDRYLLLMDLQDRNEKL
Sbjct: 88   QDLAFTLEERQQLNIHGLLPPCFISQDIQVLRIIKNFERLTSDFDRYLLLMDLQDRNEKL 147

Query: 393  FYKVLMSDIEKFMPIVYTPTVGLACQQYSLAFRKPRGLFISIHDRGHVASVLNAWPEDVI 572
            FY VLMSD+EKFMPIVYTPTVGLACQQYSLAFRKPRGLFISIHDRGH+ASVLNAWPEDVI
Sbjct: 148  FYSVLMSDLEKFMPIVYTPTVGLACQQYSLAFRKPRGLFISIHDRGHIASVLNAWPEDVI 207

Query: 573  KAVVVTDGERILGLGDLGCNGMGIPVGKLALYTACGGVNPQECLPVILDVGTENEELLKD 752
            KA+VVTDGERILGLGDLGCNGMGIPVGKLALYTACGG+NPQECLPVILDVGTENE LLKD
Sbjct: 208  KAIVVTDGERILGLGDLGCNGMGIPVGKLALYTACGGMNPQECLPVILDVGTENEALLKD 267

Query: 753  PLYIGLRQRRVRGPEYDDFLDEFMEAVSSKYGMNCLIQFEDFANINAFRLLKKYQNQYCT 932
            PLYIGLRQRRVRGPEYDDFLDEFMEAVSSKYGMNCLIQFEDFANINAFRLLKKYQN+YCT
Sbjct: 268  PLYIGLRQRRVRGPEYDDFLDEFMEAVSSKYGMNCLIQFEDFANINAFRLLKKYQNRYCT 327

Query: 933  FNDDIQGTASVAVAGILAALRITKNKLSDQTILFQGAGEAALGIAHLIVMAMEKEGVPKE 1112
            FNDDIQGTASVAVAGILAALRITKNKLSDQ ILFQGAGEAALGIAHLIVMAMEKEG+PKE
Sbjct: 328  FNDDIQGTASVAVAGILAALRITKNKLSDQKILFQGAGEAALGIAHLIVMAMEKEGLPKE 387

Query: 1113 KAIKKIWLVDSKGLIVKGRAALTNXXXXXXXXXXXMKNLEAIVQDIKPTALIGVAAIGGA 1292
            KA+K IWLVDSKGLIVKGRAALT            MKNLEAIVQ+IKPTALIGVAAIGGA
Sbjct: 388  KAMKNIWLVDSKGLIVKGRAALTQEKEQFAHEHEEMKNLEAIVQEIKPTALIGVAAIGGA 447

Query: 1293 FSEQILKDMAAFNERPIIFALSNPTSKAECTAEQCYTLTQGRAIFASGSPFDPVTLPSGQ 1472
            FSEQILKDMAAFNERPIIFALSNPTSKAECTAEQCY LT+GRAIFASGSPFDPVTLP+G+
Sbjct: 448  FSEQILKDMAAFNERPIIFALSNPTSKAECTAEQCYKLTKGRAIFASGSPFDPVTLPNGR 507

Query: 1473 TLYPGQGNNSYVFPGVALGVVACGLRHITDKILLTTAEVIAQQVSDKHLEEGRLYPPLNT 1652
            TLYPGQGNNSYVFPGVALGVVACGLRHITD I LTTAE+IAQQVSDKHLEEGRLYPPL+T
Sbjct: 508  TLYPGQGNNSYVFPGVALGVVACGLRHITDNIFLTTAEIIAQQVSDKHLEEGRLYPPLDT 567

Query: 1653 IRDVSLKIAEKIVRDAYQEKTATIYPEPSNKEAFVRSQMYSTDYDQILPDGYSWPEEAQK 1832
            IRDVSLKIA KIV+DAYQEKTAT+YPEP NKEAFVRSQMY TDYDQILPD YSWPEEAQK
Sbjct: 568  IRDVSLKIAAKIVKDAYQEKTATVYPEPPNKEAFVRSQMYDTDYDQILPDCYSWPEEAQK 627

Query: 1833 IQTKLD 1850
            IQTKLD
Sbjct: 628  IQTKLD 633


>ref|XP_848770.1| PREDICTED: similar to malic enzyme 3, NADP(+)-dependent,
            mitochondrial isoform 2 [Canis familiaris]
          Length = 604

 Score =  840 bits (2171), Expect = 0.0
 Identities = 403/556 (72%), Positives = 481/556 (86%)
 Frame = +3

Query: 174  QRGYAVTRIPHLNKDLAFTLEERQQLNIHGLLPPCFISQDIQVLRVIKNFERLNSDFDRY 353
            +RGY VTR PHLNK +AFTLEER QL IHGL+PPCF+SQD+Q+LR+++ +ER  SD D+Y
Sbjct: 48   KRGYDVTRNPHLNKGMAFTLEERLQLGIHGLIPPCFLSQDVQLLRIMRYYERQQSDLDKY 107

Query: 354  LLLMDLQDRNEKLFYKVLMSDIEKFMPIVYTPTVGLACQQYSLAFRKPRGLFISIHDRGH 533
            ++LM LQDRNEKLFY+VL SD+EKFMPIVYTPTVGLACQQY L FR+PRGLFI+IHD+GH
Sbjct: 108  IILMTLQDRNEKLFYRVLTSDVEKFMPIVYTPTVGLACQQYGLTFRRPRGLFITIHDKGH 167

Query: 534  VASVLNAWPEDVIKAVVVTDGERILGLGDLGCNGMGIPVGKLALYTACGGVNPQECLPVI 713
            +A++LN+WPED IKAVVVTDGERILGLGDLGC GMGIPVGKLALYTACGGV+PQ+CLPV+
Sbjct: 168  LATMLNSWPEDDIKAVVVTDGERILGLGDLGCYGMGIPVGKLALYTACGGVSPQQCLPVL 227

Query: 714  LDVGTENEELLKDPLYIGLRQRRVRGPEYDDFLDEFMEAVSSKYGMNCLIQFEDFANINA 893
            LDVGT NEELL+DPLYIGL+ +RVRG EYDD LDEFM+AV+ K+G+NCLIQFEDFAN NA
Sbjct: 228  LDVGTNNEELLRDPLYIGLKHQRVRGKEYDDLLDEFMQAVTDKFGINCLIQFEDFANANA 287

Query: 894  FRLLKKYQNQYCTFNDDIQGTASVAVAGILAALRITKNKLSDQTILFQGAGEAALGIAHL 1073
            FRLL KY+N+YC FNDDIQGTASVAVAGILAALRITKNKLS+   +FQGAGEAA+GIAHL
Sbjct: 288  FRLLNKYRNKYCMFNDDIQGTASVAVAGILAALRITKNKLSNHVFVFQGAGEAAMGIAHL 347

Query: 1074 IVMAMEKEGVPKEKAIKKIWLVDSKGLIVKGRAALTNXXXXXXXXXXXMKNLEAIVQDIK 1253
            +VMA+EKEGVPK +A +KIW+VDSKGLIVKGR+ L +           +K+LE +V+ +K
Sbjct: 348  LVMALEKEGVPKAEATRKIWMVDSKGLIVKGRSHLNHEKEMFAQDHPEVKSLEEVVRLVK 407

Query: 1254 PTALIGVAAIGGAFSEQILKDMAAFNERPIIFALSNPTSKAECTAEQCYTLTQGRAIFAS 1433
            PTA+IGVAAI GAF+EQIL+DMA+F+ERPIIFALSNPTSKAECTAE+CY +T+GR IFAS
Sbjct: 408  PTAIIGVAAIAGAFTEQILRDMASFHERPIIFALSNPTSKAECTAEKCYRVTEGRGIFAS 467

Query: 1434 GSPFDPVTLPSGQTLYPGQGNNSYVFPGVALGVVACGLRHITDKILLTTAEVIAQQVSDK 1613
            GSPF  VTL  G+T  PGQGNN+YVFPGVALGV+A G+RHI D+I L TAE IAQ+VS++
Sbjct: 468  GSPFKSVTLEDGRTFIPGQGNNAYVFPGVALGVIAGGIRHIPDEIFLLTAEQIAQEVSEQ 527

Query: 1614 HLEEGRLYPPLNTIRDVSLKIAEKIVRDAYQEKTATIYPEPSNKEAFVRSQMYSTDYDQI 1793
            HL +GRLYPPL+TIRDVSL+IA K++  AY+   A+ YPEP +KEAFVRS +Y+ DYD  
Sbjct: 528  HLSQGRLYPPLSTIRDVSLRIAIKVLDFAYKHNLASYYPEPKDKEAFVRSLVYTPDYDSF 587

Query: 1794 LPDGYSWPEEAQKIQT 1841
              D Y+WP+EA  +QT
Sbjct: 588  TLDSYTWPKEAMNVQT 603


>ref|XP_542269.2| PREDICTED: similar to malic enzyme 3, NADP(+)-dependent,
            mitochondrial isoform 1 [Canis familiaris]
          Length = 569

 Score =  804 bits (2076), Expect = 0.0
 Identities = 392/568 (69%), Positives = 469/568 (82%), Gaps = 27/568 (4%)
 Frame = +3

Query: 219  LAFTLEERQQLNIHGLLPPCFISQDIQVLRVIKNFERLNSDFDRYLLLMDLQDRNEKLFY 398
            +AFTLEER QL IHGL+PPCF+SQD+Q+LR+++ +ER  SD D+Y++LM LQDRNEKLFY
Sbjct: 1    MAFTLEERLQLGIHGLIPPCFLSQDVQLLRIMRYYERQQSDLDKYIILMTLQDRNEKLFY 60

Query: 399  KVLMSDIEKFMPIVYTPTVGLACQQYSLAFRKPR-------------------------- 500
            +VL SD+EKFMPIVYTPTVGLACQQY L FR+PR                          
Sbjct: 61   RVLTSDVEKFMPIVYTPTVGLACQQYGLTFRRPRSAKEGLRGESHYGVDSLSSEGLSCSA 120

Query: 501  -GLFISIHDRGHVASVLNAWPEDVIKAVVVTDGERILGLGDLGCNGMGIPVGKLALYTAC 677
             GLFI+IHD+GH+A++LN+WPED IKAVVVTDGERILGLGDLGC GMGIPVGKLALYTAC
Sbjct: 121  RGLFITIHDKGHLATMLNSWPEDDIKAVVVTDGERILGLGDLGCYGMGIPVGKLALYTAC 180

Query: 678  GGVNPQECLPVILDVGTENEELLKDPLYIGLRQRRVRGPEYDDFLDEFMEAVSSKYGMNC 857
            GGV+PQ+CLPV+LDVGT NEELL+DPLYIGL+ +RVRG EYDD LDEFM+AV+ K+G+NC
Sbjct: 181  GGVSPQQCLPVLLDVGTNNEELLRDPLYIGLKHQRVRGKEYDDLLDEFMQAVTDKFGINC 240

Query: 858  LIQFEDFANINAFRLLKKYQNQYCTFNDDIQGTASVAVAGILAALRITKNKLSDQTILFQ 1037
            LIQFEDFAN NAFRLL KY+N+YC FNDDIQGTASVAVAGILAALRITKNKLS+   +FQ
Sbjct: 241  LIQFEDFANANAFRLLNKYRNKYCMFNDDIQGTASVAVAGILAALRITKNKLSNHVFVFQ 300

Query: 1038 GAGEAALGIAHLIVMAMEKEGVPKEKAIKKIWLVDSKGLIVKGRAALTNXXXXXXXXXXX 1217
            GAGEAA+GIAHL+VMA+EKEGVPK +A +KIW+VDSKGLIVKGR+ L +           
Sbjct: 301  GAGEAAMGIAHLLVMALEKEGVPKAEATRKIWMVDSKGLIVKGRSHLNHEKEMFAQDHPE 360

Query: 1218 MKNLEAIVQDIKPTALIGVAAIGGAFSEQILKDMAAFNERPIIFALSNPTSKAECTAEQC 1397
            +K+LE +V+ +KPTA+IGVAAI GAF+EQIL+DMA+F+ERPIIFALSNPTSKAECTAE+C
Sbjct: 361  VKSLEEVVRLVKPTAIIGVAAIAGAFTEQILRDMASFHERPIIFALSNPTSKAECTAEKC 420

Query: 1398 YTLTQGRAIFASGSPFDPVTLPSGQTLYPGQGNNSYVFPGVALGVVACGLRHITDKILLT 1577
            Y +T+GR IFASGSPF  VTL  G+T  PGQGNN+YVFPGVALGV+A G+RHI D+I L 
Sbjct: 421  YRVTEGRGIFASGSPFKSVTLEDGRTFIPGQGNNAYVFPGVALGVIAGGIRHIPDEIFLL 480

Query: 1578 TAEVIAQQVSDKHLEEGRLYPPLNTIRDVSLKIAEKIVRDAYQEKTATIYPEPSNKEAFV 1757
            TAE IAQ+VS++HL +GRLYPPL+TIRDVSL+IA K++  AY+   A+ YPEP +KEAFV
Sbjct: 481  TAEQIAQEVSEQHLSQGRLYPPLSTIRDVSLRIAIKVLDFAYKHNLASYYPEPKDKEAFV 540

Query: 1758 RSQMYSTDYDQILPDGYSWPEEAQKIQT 1841
            RS +Y+ DYD    D Y+WP+EA  +QT
Sbjct: 541  RSLVYTPDYDSFTLDSYTWPKEAMNVQT 568


>ref|XP_857227.1| PREDICTED: similar to malic enzyme 3, NADP(+)-dependent,
            mitochondrial isoform 7 [Canis familiaris]
          Length = 562

 Score =  801 bits (2070), Expect = 0.0
 Identities = 390/561 (69%), Positives = 468/561 (83%), Gaps = 20/561 (3%)
 Frame = +3

Query: 219  LAFTLEERQQLNIHGLLPPCFISQDIQVLRVIKNFERLNSDFDRYLLLMDLQDRNEKLFY 398
            +AFTLEER QL IHGL+PPCF+SQD+Q+LR+++ +ER  SD D+Y++LM LQDRNEKLFY
Sbjct: 1    MAFTLEERLQLGIHGLIPPCFLSQDVQLLRIMRYYERQQSDLDKYIILMTLQDRNEKLFY 60

Query: 399  KVLMSDIEKFMPIVYTPTVGLACQQYSLAFRKPRGLFISIHDRGHVASVLNAWPEDVIKA 578
            +VL SD+EKFMPIVYTPTVGLACQQY L FR+PRGLFI+IHD+GH+A++LN+WPED IKA
Sbjct: 61   RVLTSDVEKFMPIVYTPTVGLACQQYGLTFRRPRGLFITIHDKGHLATMLNSWPEDDIKA 120

Query: 579  VVVTDGERILGLGDLGCNGMGIPVGKLALYTACGGVNPQECLPVILDVGTENEELLKDPL 758
            VVVTDGERILGLGDLGC GMGIPVGKLALYTACGGV+PQ+CLPV+LDVGT NEELL+DPL
Sbjct: 121  VVVTDGERILGLGDLGCYGMGIPVGKLALYTACGGVSPQQCLPVLLDVGTNNEELLRDPL 180

Query: 759  YIGLRQRRVRGPEYDDFLDEFMEAVSSKYGMNCLIQFEDFANINAFRLLKKYQNQYCTFN 938
            YIGL+ +RVRG EYDD LDEFM+AV+ K+G+NCLIQFEDFAN NAFRLL KY+N+YC FN
Sbjct: 181  YIGLKHQRVRGKEYDDLLDEFMQAVTDKFGINCLIQFEDFANANAFRLLNKYRNKYCMFN 240

Query: 939  DDIQGTASVAVAGILAALRITKNKLSDQTILFQGAGEAALGIAHLIVMAMEKEGVPKEKA 1118
            DDIQGTASVAVAGILAALRITKNKLS+   +FQGAGEAA+GIAHL+VMA+EKEGVPK +A
Sbjct: 241  DDIQGTASVAVAGILAALRITKNKLSNHVFVFQGAGEAAMGIAHLLVMALEKEGVPKAEA 300

Query: 1119 IKKIWLVDSKGLIVKGRAA--------------------LTNXXXXXXXXXXXMKNLEAI 1238
             +KIW+VDSKGLIVK  ++                    L +           +K+LE +
Sbjct: 301  TRKIWMVDSKGLIVKVLSSSYQCLACNECVIMPADPKDHLNHEKEMFAQDHPEVKSLEEV 360

Query: 1239 VQDIKPTALIGVAAIGGAFSEQILKDMAAFNERPIIFALSNPTSKAECTAEQCYTLTQGR 1418
            V+ +KPTA+IGVAAI GAF+EQIL+DMA+F+ERPIIFALSNPTSKAECTAE+CY +T+GR
Sbjct: 361  VRLVKPTAIIGVAAIAGAFTEQILRDMASFHERPIIFALSNPTSKAECTAEKCYRVTEGR 420

Query: 1419 AIFASGSPFDPVTLPSGQTLYPGQGNNSYVFPGVALGVVACGLRHITDKILLTTAEVIAQ 1598
             IFASGSPF  VTL  G+T  PGQGNN+YVFPGVALGV+A G+RHI D+I L TAE IAQ
Sbjct: 421  GIFASGSPFKSVTLEDGRTFIPGQGNNAYVFPGVALGVIAGGIRHIPDEIFLLTAEQIAQ 480

Query: 1599 QVSDKHLEEGRLYPPLNTIRDVSLKIAEKIVRDAYQEKTATIYPEPSNKEAFVRSQMYST 1778
            +VS++HL +GRLYPPL+TIRDVSL+IA K++  AY+   A+ YPEP +KEAFVRS +Y+ 
Sbjct: 481  EVSEQHLSQGRLYPPLSTIRDVSLRIAIKVLDFAYKHNLASYYPEPKDKEAFVRSLVYTP 540

Query: 1779 DYDQILPDGYSWPEEAQKIQT 1841
            DYD    D Y+WP+EA  +QT
Sbjct: 541  DYDSFTLDSYTWPKEAMNVQT 561


>ref|XP_857135.1| PREDICTED: similar to malic enzyme 3, NADP(+)-dependent,
            mitochondrial isoform 5 [Canis familiaris]
          Length = 573

 Score =  798 bits (2061), Expect = 0.0
 Identities = 392/572 (68%), Positives = 469/572 (81%), Gaps = 31/572 (5%)
 Frame = +3

Query: 219  LAFTLEERQQLNIHGLLPPCFISQDIQVLRVIKNFERLNSDFDRYLLLMDLQDRNEKLFY 398
            +AFTLEER QL IHGL+PPCF+SQD+Q+LR+++ +ER  SD D+Y++LM LQDRNEKLFY
Sbjct: 1    MAFTLEERLQLGIHGLIPPCFLSQDVQLLRIMRYYERQQSDLDKYIILMTLQDRNEKLFY 60

Query: 399  KVLMSDIEKFMPIVYTPTVGLACQQYSLAFRKPRGLFISIHDRGHVASVLNAWPEDVIKA 578
            +VL SD+EKFMPIVYTPTVGLACQQY L FR+PRGLFI+IHD+GH+A++LN+WPED IKA
Sbjct: 61   RVLTSDVEKFMPIVYTPTVGLACQQYGLTFRRPRGLFITIHDKGHLATMLNSWPEDDIKA 120

Query: 579  VVVTDGERILGLGDLGCNGMGIPVGKLALYTACGGVNPQECLPVILDVGTENEELLKDPL 758
            VVVTDGERILGLGDLGC GMGIPVGKLALYTACGGV+PQ+CLPV+LDVGT NEELL+DPL
Sbjct: 121  VVVTDGERILGLGDLGCYGMGIPVGKLALYTACGGVSPQQCLPVLLDVGTNNEELLRDPL 180

Query: 759  YIGLRQRRVRGPEYDDFLDEFMEAVSSKYGMNCLIQFEDFANINAFRLLKKYQNQYCTFN 938
            YIGL+ +RVRG EYDD LDEFM+AV+ K+G+NCLIQFEDFAN NAFRLL KY+N+YC FN
Sbjct: 181  YIGLKHQRVRGKEYDDLLDEFMQAVTDKFGINCLIQFEDFANANAFRLLNKYRNKYCMFN 240

Query: 939  DDIQGTASVAVAGILAALRITKNKLSDQTILFQGAGEAALGIAHLIVMAMEKEGVPKEKA 1118
            DDIQGTASVAVAGILAALRITKNKLS+   +FQGAGEAA+GIAHL+VMA+EKEGVPK +A
Sbjct: 241  DDIQGTASVAVAGILAALRITKNKLSNHVFVFQGAGEAAMGIAHLLVMALEKEGVPKAEA 300

Query: 1119 IKKIWLVDSKGLIVK---GRAALTNXXXXXXXXXXXMKNLEAIVQDIKPTALIGVAAIGG 1289
             +KIW+VDSKGLIVK   GR+ L +           +K+LE +V+ +KPTA+IGVAAI G
Sbjct: 301  TRKIWMVDSKGLIVKVLSGRSHLNHEKEMFAQDHPEVKSLEEVVRLVKPTAIIGVAAIAG 360

Query: 1290 AFSEQILKDMAAFNERPIIFALSNPTSKAECTAEQCYTLTQ------------------- 1412
            AF+EQIL+DMA+F+ERPIIFALSNPTSKAECTAE+CY +T+                   
Sbjct: 361  AFTEQILRDMASFHERPIIFALSNPTSKAECTAEKCYRVTEVSGESFLPQAERTYPSSYH 420

Query: 1413 ---------GRAIFASGSPFDPVTLPSGQTLYPGQGNNSYVFPGVALGVVACGLRHITDK 1565
                     GR IFASGSPF  VTL  G+T  PGQGNN+YVFPGVALGV+A G+RHI D+
Sbjct: 421  HVILFRVPLGRGIFASGSPFKSVTLEDGRTFIPGQGNNAYVFPGVALGVIAGGIRHIPDE 480

Query: 1566 ILLTTAEVIAQQVSDKHLEEGRLYPPLNTIRDVSLKIAEKIVRDAYQEKTATIYPEPSNK 1745
            I L TAE IAQ+VS++HL +GRLYPPL+TIRDVSL+IA K++  AY+   A+ YPEP +K
Sbjct: 481  IFLLTAEQIAQEVSEQHLSQGRLYPPLSTIRDVSLRIAIKVLDFAYKHNLASYYPEPKDK 540

Query: 1746 EAFVRSQMYSTDYDQILPDGYSWPEEAQKIQT 1841
            EAFVRS +Y+ DYD    D Y+WP+EA  +QT
Sbjct: 541  EAFVRSLVYTPDYDSFTLDSYTWPKEAMNVQT 572


>ref|XP_857177.1| PREDICTED: similar to malic enzyme 3, NADP(+)-dependent,
            mitochondrial isoform 6 [Canis familiaris]
          Length = 513

 Score =  746 bits (1926), Expect = 0.0
 Identities = 363/541 (67%), Positives = 437/541 (80%)
 Frame = +3

Query: 219  LAFTLEERQQLNIHGLLPPCFISQDIQVLRVIKNFERLNSDFDRYLLLMDLQDRNEKLFY 398
            +AFTLEER QL IHGL+PPCF+SQD+Q+LR+++ +ER  SD D+Y++LM LQDRNEKLFY
Sbjct: 1    MAFTLEERLQLGIHGLIPPCFLSQDVQLLRIMRYYERQQSDLDKYIILMTLQDRNEKLFY 60

Query: 399  KVLMSDIEKFMPIVYTPTVGLACQQYSLAFRKPRGLFISIHDRGHVASVLNAWPEDVIKA 578
            +VL SD+EKFMPIVYTPTVGLACQQY L FR+PRGLFI+IHD+GH+A++LN+WPED IKA
Sbjct: 61   RVLTSDVEKFMPIVYTPTVGLACQQYGLTFRRPRGLFITIHDKGHLATMLNSWPEDDIKA 120

Query: 579  VVVTDGERILGLGDLGCNGMGIPVGKLALYTACGGVNPQECLPVILDVGTENEELLKDPL 758
            VVVTDGERILGLGDLGC GMGIPVGKLALYTACGGV+PQ+CLPV+LDVGT NEELL+DPL
Sbjct: 121  VVVTDGERILGLGDLGCYGMGIPVGKLALYTACGGVSPQQCLPVLLDVGTNNEELLRDPL 180

Query: 759  YIGLRQRRVRGPEYDDFLDEFMEAVSSKYGMNCLIQFEDFANINAFRLLKKYQNQYCTFN 938
            YIGL+ +RVRG EYDD LDEFM+AV+ K+G+NCLIQFEDFAN NAFRLL KY+N+YC FN
Sbjct: 181  YIGLKHQRVRGKEYDDLLDEFMQAVTDKFGINCLIQFEDFANANAFRLLNKYRNKYCMFN 240

Query: 939  DDIQGTASVAVAGILAALRITKNKLSDQTILFQGAGEAALGIAHLIVMAMEKEGVPKEKA 1118
            DDIQGTASVAVAGILAALRITKNKLS+   +FQGAGEAA+GIAHL+VMA+EKEGVPK +A
Sbjct: 241  DDIQGTASVAVAGILAALRITKNKLSNHVFVFQGAGEAAMGIAHLLVMALEKEGVPKAEA 300

Query: 1119 IKKIWLVDSKGLIVKGRAALTNXXXXXXXXXXXMKNLEAIVQDIKPTALIGVAAIGGAFS 1298
             +KIW+VDSKGLIVKGR+ L +           +K+LE +V+ +KPTA+IG         
Sbjct: 301  TRKIWMVDSKGLIVKGRSHLNHEKEMFAQDHPEVKSLEEVVRLVKPTAIIG--------- 351

Query: 1299 EQILKDMAAFNERPIIFALSNPTSKAECTAEQCYTLTQGRAIFASGSPFDPVTLPSGQTL 1478
                                    +AECTAE+CY +T+GR IFASGSPF  VTL  G+T 
Sbjct: 352  --------------------RRRQEAECTAEKCYRVTEGRGIFASGSPFKSVTLEDGRTF 391

Query: 1479 YPGQGNNSYVFPGVALGVVACGLRHITDKILLTTAEVIAQQVSDKHLEEGRLYPPLNTIR 1658
             PGQGNN+YVFPGVALGV+A G+RHI D+I L TAE IAQ+VS++HL +GRLYPPL+TIR
Sbjct: 392  IPGQGNNAYVFPGVALGVIAGGIRHIPDEIFLLTAEQIAQEVSEQHLSQGRLYPPLSTIR 451

Query: 1659 DVSLKIAEKIVRDAYQEKTATIYPEPSNKEAFVRSQMYSTDYDQILPDGYSWPEEAQKIQ 1838
            DVSL+IA K++  AY+   A+ YPEP +KEAFVRS +Y+ DYD    D Y+WP+EA  +Q
Sbjct: 452  DVSLRIAIKVLDFAYKHNLASYYPEPKDKEAFVRSLVYTPDYDSFTLDSYTWPKEAMNVQ 511

Query: 1839 T 1841
            T
Sbjct: 512  T 512


>ref|XP_849530.1| PREDICTED: similar to NAD-dependent malic enzyme, mitochondrial
            precursor (NAD-ME) (Malic enzyme 2) isoform 2 [Canis
            familiaris]
          Length = 584

 Score =  652 bits (1683), Expect = 0.0
 Identities = 318/562 (56%), Positives = 406/562 (72%), Gaps = 3/562 (0%)
 Frame = +3

Query: 150  APRRRHTLQRGYAVTRIPHLNKDLAFTLEERQQLNIHGLLPPCFISQDIQVLRVIKNFER 329
            A R  H  ++G  +   P  NK +AFTL+ERQ L + GLLPP   +QDIQ LR  KN ++
Sbjct: 15   ACRHIHIKEKGKPLMLNPRTNKGMAFTLQERQMLGLQGLLPPKIETQDIQALRFHKNVKK 74

Query: 330  LNSDFDRYLLLMDLQDRNEKLFYKVLMSDIEKFMPIVYTPTVGLACQQYSLAFRKPRGLF 509
            +N   ++Y+ +M +Q+RNEKLFY++L  DIE  MPIVYTPTVGLAC QY   FR+P+GLF
Sbjct: 75   MNGPLEKYIYIMGIQERNEKLFYRILQDDIESLMPIVYTPTVGLACSQYGHIFRRPKGLF 134

Query: 510  ISIHDRGHVASVLNAWPEDVIKAVVVTDGERILGLGDLGCNGMGIPVGKLALYTACGGVN 689
            ISI DRGHV S+++ WPE+ +KAVVVTDGERILGLGDLG  GMGIPVGKL LYTAC G+ 
Sbjct: 135  ISISDRGHVRSIVDNWPENHVKAVVVTDGERILGLGDLGVYGMGIPVGKLCLYTACAGIR 194

Query: 690  PQECLPVILDVGTENEELLKDPLYIGLRQRRVRGPEYDDFLDEFMEAVSSKYGMNCLIQF 869
            P  CLPV +DVGT+N  LLKDP Y+GL Q+R R   YDD +DEFM+A++ +YG N LIQF
Sbjct: 195  PDRCLPVCIDVGTDNPALLKDPFYMGLYQKRDRSQRYDDLIDEFMKAITDRYGQNTLIQF 254

Query: 870  EDFANINAFRLLKKYQNQYCTFNDDIQGTASVAVAGILAALRITKNKLSDQTILFQGAGE 1049
            EDF N NAFR L+KY+ +YCTFNDDIQGTA+VA+AG+LAA ++     S+  ILF GAGE
Sbjct: 255  EDFGNHNAFRFLRKYREKYCTFNDDIQGTAAVALAGLLAAQKVIGKSFSEHKILFLGAGE 314

Query: 1050 AALGIAHLIVMAMEKEGVPKEKAIKKIWLVDSKGLIVKGR-AALTNXXXXXXXXXXXM-- 1220
            AALGIA+LIVMAM + G+ +E+A KKIW+VD  GL+ KGR A + N           +  
Sbjct: 315  AALGIANLIVMAMVENGLSEEEAQKKIWMVDKFGLLFKGRKAKIENHQEPFAHSAPGIIP 374

Query: 1221 KNLEAIVQDIKPTALIGVAAIGGAFSEQILKDMAAFNERPIIFALSNPTSKAECTAEQCY 1400
               E  V  ++P+A+IGVA  G  F+  ++K MA  NERP+IFALSNPT+ AECTAE+ Y
Sbjct: 375  DTFEDAVNILRPSAIIGVAGAGRLFTPGVIKAMADINERPVIFALSNPTAMAECTAEEAY 434

Query: 1401 TLTQGRAIFASGSPFDPVTLPSGQTLYPGQGNNSYVFPGVALGVVACGLRHITDKILLTT 1580
            TLT+GR +FASGSPF+PV L  GQ   PGQGNN Y+FPGVAL V+ C  RHI+D + L  
Sbjct: 435  TLTEGRCLFASGSPFEPVKLSDGQLFTPGQGNNVYIFPGVALAVILCNTRHISDHVFLEA 494

Query: 1581 AEVIAQQVSDKHLEEGRLYPPLNTIRDVSLKIAEKIVRDAYQEKTATIYPEPSNKEAFVR 1760
            A+ +A Q++DK L +GRLYPPL  I++VS+ IA K+    Y  K A  YPEP +K  ++R
Sbjct: 495  AKALANQLTDKELAQGRLYPPLADIQEVSINIAIKVTEYLYANKMAFRYPEPEDKAKYIR 554

Query: 1761 SQMYSTDYDQILPDGYSWPEEA 1826
             +++ ++YD +LPD Y WPE A
Sbjct: 555  ERIWRSEYDSLLPDVYDWPESA 576


>ref|XP_533402.2| PREDICTED: similar to NAD-dependent malic enzyme, mitochondrial
            precursor (NAD-ME) (Malic enzyme 2) isoform 1 [Canis
            familiaris]
          Length = 499

 Score =  594 bits (1531), Expect = e-169
 Identities = 288/491 (58%), Positives = 362/491 (73%), Gaps = 3/491 (0%)
 Frame = +3

Query: 363  MDLQDRNEKLFYKVLMSDIEKFMPIVYTPTVGLACQQYSLAFRKPRGLFISIHDRGHVAS 542
            M +Q+RNEKLFY++L  DIE  MPIVYTPTVGLAC QY   FR+P+GLFISI DRGHV S
Sbjct: 1    MGIQERNEKLFYRILQDDIESLMPIVYTPTVGLACSQYGHIFRRPKGLFISISDRGHVRS 60

Query: 543  VLNAWPEDVIKAVVVTDGERILGLGDLGCNGMGIPVGKLALYTACGGVNPQECLPVILDV 722
            +++ WPE+ +KAVVVTDGERILGLGDLG  GMGIPVGKL LYTAC G+ P  CLPV +DV
Sbjct: 61   IVDNWPENHVKAVVVTDGERILGLGDLGVYGMGIPVGKLCLYTACAGIRPDRCLPVCIDV 120

Query: 723  GTENEELLKDPLYIGLRQRRVRGPEYDDFLDEFMEAVSSKYGMNCLIQFEDFANINAFRL 902
            GT+N  LLKDP Y+GL Q+R R   YDD +DEFM+A++ +YG N LIQFEDF N NAFR 
Sbjct: 121  GTDNPALLKDPFYMGLYQKRDRSQRYDDLIDEFMKAITDRYGQNTLIQFEDFGNHNAFRF 180

Query: 903  LKKYQNQYCTFNDDIQGTASVAVAGILAALRITKNKLSDQTILFQGAGEAALGIAHLIVM 1082
            L+KY+ +YCTFNDDIQGTA+VA+AG+LAA ++     S+  ILF GAGEAALGIA+LIVM
Sbjct: 181  LRKYREKYCTFNDDIQGTAAVALAGLLAAQKVIGKSFSEHKILFLGAGEAALGIANLIVM 240

Query: 1083 AMEKEGVPKEKAIKKIWLVDSKGLIVKGR-AALTNXXXXXXXXXXXM--KNLEAIVQDIK 1253
            AM + G+ +E+A KKIW+VD  GL+ KGR A + N           +     E  V  ++
Sbjct: 241  AMVENGLSEEEAQKKIWMVDKFGLLFKGRKAKIENHQEPFAHSAPGIIPDTFEDAVNILR 300

Query: 1254 PTALIGVAAIGGAFSEQILKDMAAFNERPIIFALSNPTSKAECTAEQCYTLTQGRAIFAS 1433
            P+A+IGVA  G  F+  ++K MA  NERP+IFALSNPT+ AECTAE+ YTLT+GR +FAS
Sbjct: 301  PSAIIGVAGAGRLFTPGVIKAMADINERPVIFALSNPTAMAECTAEEAYTLTEGRCLFAS 360

Query: 1434 GSPFDPVTLPSGQTLYPGQGNNSYVFPGVALGVVACGLRHITDKILLTTAEVIAQQVSDK 1613
            GSPF+PV L  GQ   PGQGNN Y+FPGVAL V+ C  RHI+D + L  A+ +A Q++DK
Sbjct: 361  GSPFEPVKLSDGQLFTPGQGNNVYIFPGVALAVILCNTRHISDHVFLEAAKALANQLTDK 420

Query: 1614 HLEEGRLYPPLNTIRDVSLKIAEKIVRDAYQEKTATIYPEPSNKEAFVRSQMYSTDYDQI 1793
             L +GRLYPPL  I++VS+ IA K+    Y  K A  YPEP +K  ++R +++ ++YD +
Sbjct: 421  ELAQGRLYPPLADIQEVSINIAIKVTEYLYANKMAFRYPEPEDKAKYIRERIWRSEYDSL 480

Query: 1794 LPDGYSWPEEA 1826
            LPD Y WPE A
Sbjct: 481  LPDVYDWPESA 491


>ref|XP_857051.1| PREDICTED: similar to malic enzyme 3, NADP(+)-dependent,
            mitochondrial isoform 3 [Canis familiaris]
          Length = 361

 Score =  551 bits (1421), Expect = e-157
 Identities = 262/351 (74%), Positives = 311/351 (88%)
 Frame = +3

Query: 219  LAFTLEERQQLNIHGLLPPCFISQDIQVLRVIKNFERLNSDFDRYLLLMDLQDRNEKLFY 398
            +AFTLEER QL IHGL+PPCF+SQD+Q+LR+++ +ER  SD D+Y++LM LQDRNEKLFY
Sbjct: 1    MAFTLEERLQLGIHGLIPPCFLSQDVQLLRIMRYYERQQSDLDKYIILMTLQDRNEKLFY 60

Query: 399  KVLMSDIEKFMPIVYTPTVGLACQQYSLAFRKPRGLFISIHDRGHVASVLNAWPEDVIKA 578
            +VL SD+EKFMPIVYTPTVGLACQQY L FR+PRGLFI+IHD+GH+A++LN+WPED IKA
Sbjct: 61   RVLTSDVEKFMPIVYTPTVGLACQQYGLTFRRPRGLFITIHDKGHLATMLNSWPEDDIKA 120

Query: 579  VVVTDGERILGLGDLGCNGMGIPVGKLALYTACGGVNPQECLPVILDVGTENEELLKDPL 758
            VVVTDGERILGLGDLGC GMGIPVGKLALYTACGGV+PQ+CLPV+LDVGT NEELL+DPL
Sbjct: 121  VVVTDGERILGLGDLGCYGMGIPVGKLALYTACGGVSPQQCLPVLLDVGTNNEELLRDPL 180

Query: 759  YIGLRQRRVRGPEYDDFLDEFMEAVSSKYGMNCLIQFEDFANINAFRLLKKYQNQYCTFN 938
            YIGL+ +RVRG EYDD LDEFM+AV+ K+G+NCLIQFEDFAN NAFRLL KY+N+YC FN
Sbjct: 181  YIGLKHQRVRGKEYDDLLDEFMQAVTDKFGINCLIQFEDFANANAFRLLNKYRNKYCMFN 240

Query: 939  DDIQGTASVAVAGILAALRITKNKLSDQTILFQGAGEAALGIAHLIVMAMEKEGVPKEKA 1118
            DDIQGTASVAVAGILAALRITKNKLS+   +FQGAGEAA+GIAHL+VMA+EKEGVPK +A
Sbjct: 241  DDIQGTASVAVAGILAALRITKNKLSNHVFVFQGAGEAAMGIAHLLVMALEKEGVPKAEA 300

Query: 1119 IKKIWLVDSKGLIVKGRAALTNXXXXXXXXXXXMKNLEAIVQDIKPTALIG 1271
             +KIW+VDSKGLIVKGR+ L +           +K+LE +V+ +KPTA+IG
Sbjct: 301  TRKIWMVDSKGLIVKGRSHLNHEKEMFAQDHPEVKSLEEVVRLVKPTAIIG 351


>ref|XP_857091.1| PREDICTED: similar to NADP-dependent malic enzyme, mitochondrial
            precursor (NADP-ME) (Malic enzyme 3) isoform 4 [Canis
            familiaris]
          Length = 231

 Score =  296 bits (757), Expect = 7e-80
 Identities = 144/227 (63%), Positives = 180/227 (79%)
 Frame = +3

Query: 1161 KGRAALTNXXXXXXXXXXXMKNLEAIVQDIKPTALIGVAAIGGAFSEQILKDMAAFNERP 1340
            KGR+ L +           +K+LE +V+ +KPTA+IGVAAI GAF+EQIL+DMA+F+ERP
Sbjct: 4    KGRSHLNHEKEMFAQDHPEVKSLEEVVRLVKPTAIIGVAAIAGAFTEQILRDMASFHERP 63

Query: 1341 IIFALSNPTSKAECTAEQCYTLTQGRAIFASGSPFDPVTLPSGQTLYPGQGNNSYVFPGV 1520
            IIFALSNPTSKAECTAE+CY +T+GR IFASGSPF  VTL  G+T  PGQGNN+YVFPGV
Sbjct: 64   IIFALSNPTSKAECTAEKCYRVTEGRGIFASGSPFKSVTLEDGRTFIPGQGNNAYVFPGV 123

Query: 1521 ALGVVACGLRHITDKILLTTAEVIAQQVSDKHLEEGRLYPPLNTIRDVSLKIAEKIVRDA 1700
            ALGV+A G+RHI D+I L TAE IAQ+VS++HL +GRLYPPL+TIRDVSL+IA K++  A
Sbjct: 124  ALGVIAGGIRHIPDEIFLLTAEQIAQEVSEQHLSQGRLYPPLSTIRDVSLRIAIKVLDFA 183

Query: 1701 YQEKTATIYPEPSNKEAFVRSQMYSTDYDQILPDGYSWPEEAQKIQT 1841
            Y+   A+ YPEP +KEAFVRS +Y+ DYD    D Y+WP+EA  +QT
Sbjct: 184  YKHNLASYYPEPKDKEAFVRSLVYTPDYDSFTLDSYTWPKEAMNVQT 230


  Database: RefSeqCP
    Posted date:  Aug 1, 2006  9:25 PM
  Number of letters in database: 19,266,565
  Number of sequences in database:  33,732
  
Lambda     K      H
   0.318    0.134    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 79,277,383
Number of Sequences: 33732
Number of extensions: 1969684
Number of successful extensions: 5890
Number of sequences better than 1.0e-05: 10
Number of HSP's better than  0.0 without gapping: 5056
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5878
length of database: 19,266,565
effective HSP length: 110
effective length of database: 15,556,045
effective search space used: 9738084170
frameshift window, decay const: 40,  0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)

Search to RefSeqSP

BLASTX 2.2.10 [Oct-19-2004]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= LVRM1_0151_G04
         (2212 letters)

Database: RefSeqSP 
           1040 sequences; 434,620 total letters

Searching...done

 ***** No hits found ******

  Database: RefSeqSP
    Posted date:  Aug 1, 2006  7:14 PM
  Number of letters in database: 434,620
  Number of sequences in database:  1040
  
Lambda     K      H
   0.318    0.134    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 1,864,736
Number of Sequences: 1040
Number of extensions: 46536
Number of successful extensions: 107
Number of sequences better than 1.0e-05: 0
Number of HSP's better than  0.0 without gapping: 100
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 107
length of database: 434,620
effective HSP length: 84
effective length of database: 347,260
effective search space used: 226413520
frameshift window, decay const: 40,  0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)

Search to RefSeqHP

BLASTX 2.2.10 [Oct-19-2004]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= LVRM1_0151_G04
         (2212 letters)

Database: RefSeqHP 
           39,411 sequences; 17,774,539 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

Alignment   gi|NP_002386.1| cytosolic malic enzyme 1 [Homo sapiens]             1045   0.0  
Alignment   gi|NP_001014811.1| malic enzyme 3, NADP(+)-dependent, mitochond...   835   0.0  
Alignment   gi|NP_006671.2| malic enzyme 3, NADP(+)-dependent, mitochondria...   835   0.0  
Alignment   gi|NP_002387.1| malic enzyme 2, NAD(+)-dependent, mitochondrial...   645   0.0  
Alignment   gi|XP_934770.1| PREDICTED: similar to NAD-dependent malic enzym...   239   7e-63
Alignment   gi|XP_944182.1| PREDICTED: similar to NAD-dependent malic enzym...   239   7e-63

>ref|NP_002386.1| cytosolic malic enzyme 1 [Homo sapiens]
          Length = 572

 Score = 1045 bits (2703), Expect = 0.0
 Identities = 519/571 (90%), Positives = 541/571 (94%)
 Frame = +3

Query: 138  MEPRAPRRRHTLQRGYAVTRIPHLNKDLAFTLEERQQLNIHGLLPPCFISQDIQVLRVIK 317
            MEP APRRRHT QRGY +TR PHLNKDLAFTLEERQQLNIHGLLPP F SQ+IQVLRV+K
Sbjct: 1    MEPEAPRRRHTHQRGYLLTRNPHLNKDLAFTLEERQQLNIHGLLPPSFNSQEIQVLRVVK 60

Query: 318  NFERLNSDFDRYLLLMDLQDRNEKLFYKVLMSDIEKFMPIVYTPTVGLACQQYSLAFRKP 497
            NFE LNSDFDRYLLLMDLQDRNEKLFY+VL SDIEKFMPIVYTPTVGLACQQYSL FRKP
Sbjct: 61   NFEHLNSDFDRYLLLMDLQDRNEKLFYRVLTSDIEKFMPIVYTPTVGLACQQYSLVFRKP 120

Query: 498  RGLFISIHDRGHVASVLNAWPEDVIKAVVVTDGERILGLGDLGCNGMGIPVGKLALYTAC 677
            RGLFI+IHDRGH+ASVLNAWPEDVIKA+VVTDGERILGLGDLGCNGMGIPVGKLALYTAC
Sbjct: 121  RGLFITIHDRGHIASVLNAWPEDVIKAIVVTDGERILGLGDLGCNGMGIPVGKLALYTAC 180

Query: 678  GGVNPQECLPVILDVGTENEELLKDPLYIGLRQRRVRGPEYDDFLDEFMEAVSSKYGMNC 857
            GG+NPQECLPVILDVGTENEELLKDPLYIGLRQRRVRG EYDDFLDEFMEAVSSKYGMNC
Sbjct: 181  GGMNPQECLPVILDVGTENEELLKDPLYIGLRQRRVRGSEYDDFLDEFMEAVSSKYGMNC 240

Query: 858  LIQFEDFANINAFRLLKKYQNQYCTFNDDIQGTASVAVAGILAALRITKNKLSDQTILFQ 1037
            LIQFEDFAN+NAFRLL KY+NQYCTFNDDIQGTASVAVAG+LAALRITKNKLSDQTILFQ
Sbjct: 241  LIQFEDFANVNAFRLLNKYRNQYCTFNDDIQGTASVAVAGLLAALRITKNKLSDQTILFQ 300

Query: 1038 GAGEAALGIAHLIVMAMEKEGVPKEKAIKKIWLVDSKGLIVKGRAALTNXXXXXXXXXXX 1217
            GAGEAALGIAHLIVMA+EKEG+PKEKAIKKIWLVDSKGLIVKGRA+LT            
Sbjct: 301  GAGEAALGIAHLIVMALEKEGLPKEKAIKKIWLVDSKGLIVKGRASLTQEKEKFAHEHEE 360

Query: 1218 MKNLEAIVQDIKPTALIGVAAIGGAFSEQILKDMAAFNERPIIFALSNPTSKAECTAEQC 1397
            MKNLEAIVQ+IKPTALIGVAAIGGAFSEQILKDMAAFNERPIIFALSNPTSKAEC+AEQC
Sbjct: 361  MKNLEAIVQEIKPTALIGVAAIGGAFSEQILKDMAAFNERPIIFALSNPTSKAECSAEQC 420

Query: 1398 YTLTQGRAIFASGSPFDPVTLPSGQTLYPGQGNNSYVFPGVALGVVACGLRHITDKILLT 1577
            Y +T+GRAIFASGSPFDPVTLP+GQTLYPGQGNNSYVFPGVALGVVACGLR ITD I LT
Sbjct: 421  YKITKGRAIFASGSPFDPVTLPNGQTLYPGQGNNSYVFPGVALGVVACGLRQITDNIFLT 480

Query: 1578 TAEVIAQQVSDKHLEEGRLYPPLNTIRDVSLKIAEKIVRDAYQEKTATIYPEPSNKEAFV 1757
            TAEVIAQQVSDKHLEEGRLYPPLNTIRDVSLKIAEKIV+DAYQEKTAT+YPEP NKEAFV
Sbjct: 481  TAEVIAQQVSDKHLEEGRLYPPLNTIRDVSLKIAEKIVKDAYQEKTATVYPEPQNKEAFV 540

Query: 1758 RSQMYSTDYDQILPDGYSWPEEAQKIQTKLD 1850
            RSQMYSTDYDQILPD YSWPEE QKIQTK+D
Sbjct: 541  RSQMYSTDYDQILPDCYSWPEEVQKIQTKVD 571


>ref|NP_001014811.1| malic enzyme 3, NADP(+)-dependent, mitochondrial [Homo sapiens]
          Length = 604

 Score =  835 bits (2157), Expect = 0.0
 Identities = 406/585 (69%), Positives = 488/585 (83%)
 Frame = +3

Query: 87   GSIRPLSPVPPRQRQPAMEPRAPRRRHTLQRGYAVTRIPHLNKDLAFTLEERQQLNIHGL 266
            G++   +P  P Q   + +P   R     +RGY VTR PHLNK +AFTLEER QL IHGL
Sbjct: 20   GALPRWTPTAPAQGCHS-KPGPARPVPLKKRGYDVTRNPHLNKGMAFTLEERLQLGIHGL 78

Query: 267  LPPCFISQDIQVLRVIKNFERLNSDFDRYLLLMDLQDRNEKLFYKVLMSDIEKFMPIVYT 446
            +PPCF+SQD+Q+LR+++ +ER  SD D+Y++LM LQDRNEKLFY+VL SD+EKFMPIVYT
Sbjct: 79   IPPCFLSQDVQLLRIMRYYERQQSDLDKYIILMTLQDRNEKLFYRVLTSDVEKFMPIVYT 138

Query: 447  PTVGLACQQYSLAFRKPRGLFISIHDRGHVASVLNAWPEDVIKAVVVTDGERILGLGDLG 626
            PTVGLACQ Y L FR+PRGLFI+IHD+GH+A++LN+WPED IKAVVVTDGERILGLGDLG
Sbjct: 139  PTVGLACQHYGLTFRRPRGLFITIHDKGHLATMLNSWPEDNIKAVVVTDGERILGLGDLG 198

Query: 627  CNGMGIPVGKLALYTACGGVNPQECLPVILDVGTENEELLKDPLYIGLRQRRVRGPEYDD 806
            C GMGIPVGKLALYTACGGVNPQ+CLPV+LDVGT NEELL+DPLYIGL+ +RV G  YDD
Sbjct: 199  CYGMGIPVGKLALYTACGGVNPQQCLPVLLDVGTNNEELLRDPLYIGLKHQRVHGKAYDD 258

Query: 807  FLDEFMEAVSSKYGMNCLIQFEDFANINAFRLLKKYQNQYCTFNDDIQGTASVAVAGILA 986
             LDEFM+AV+ K+G+NCLIQFEDFAN NAFRLL KY+N+YC FNDDIQGTASVAVAGILA
Sbjct: 259  LLDEFMQAVTDKFGINCLIQFEDFANANAFRLLNKYRNKYCMFNDDIQGTASVAVAGILA 318

Query: 987  ALRITKNKLSDQTILFQGAGEAALGIAHLIVMAMEKEGVPKEKAIKKIWLVDSKGLIVKG 1166
            ALRITKNKLS+   +FQGAGEAA+GIAHL+VMA+EKEGVPK +A +KIW+VDSKGLIVKG
Sbjct: 319  ALRITKNKLSNHVFVFQGAGEAAMGIAHLLVMALEKEGVPKAEATRKIWMVDSKGLIVKG 378

Query: 1167 RAALTNXXXXXXXXXXXMKNLEAIVQDIKPTALIGVAAIGGAFSEQILKDMAAFNERPII 1346
            R+ L +           + +LE +V+ +KPTA+IGVAAI GAF+EQIL+DMA+F+ERPII
Sbjct: 379  RSHLNHEKEMFAQDHPEVNSLEEVVRLVKPTAIIGVAAIAGAFTEQILRDMASFHERPII 438

Query: 1347 FALSNPTSKAECTAEQCYTLTQGRAIFASGSPFDPVTLPSGQTLYPGQGNNSYVFPGVAL 1526
            FALSNPTSKAECTAE+CY +T+GR IFASGSPF  VTL  G+T  PGQGNN+YVFPGVAL
Sbjct: 439  FALSNPTSKAECTAEKCYRVTEGRGIFASGSPFKSVTLEDGKTFIPGQGNNAYVFPGVAL 498

Query: 1527 GVVACGLRHITDKILLTTAEVIAQQVSDKHLEEGRLYPPLNTIRDVSLKIAEKIVRDAYQ 1706
            GV+A G+RHI D+I L TAE IAQ+VS++HL +GRLYPPL+TIRDVSL+IA K++  AY+
Sbjct: 499  GVIAGGIRHIPDEIFLLTAEQIAQEVSEQHLSQGRLYPPLSTIRDVSLRIAIKVLDYAYK 558

Query: 1707 EKTATIYPEPSNKEAFVRSQMYSTDYDQILPDGYSWPEEAQKIQT 1841
               A+ YPEP +KEAFVRS +Y+ DYD    D Y+WP+EA  +QT
Sbjct: 559  HNLASYYPEPKDKEAFVRSLVYTPDYDSFTLDSYTWPKEAMNVQT 603


>ref|NP_006671.2| malic enzyme 3, NADP(+)-dependent, mitochondrial [Homo sapiens]
          Length = 604

 Score =  835 bits (2157), Expect = 0.0
 Identities = 406/585 (69%), Positives = 488/585 (83%)
 Frame = +3

Query: 87   GSIRPLSPVPPRQRQPAMEPRAPRRRHTLQRGYAVTRIPHLNKDLAFTLEERQQLNIHGL 266
            G++   +P  P Q   + +P   R     +RGY VTR PHLNK +AFTLEER QL IHGL
Sbjct: 20   GALPRWTPTAPAQGCHS-KPGPARPVPLKKRGYDVTRNPHLNKGMAFTLEERLQLGIHGL 78

Query: 267  LPPCFISQDIQVLRVIKNFERLNSDFDRYLLLMDLQDRNEKLFYKVLMSDIEKFMPIVYT 446
            +PPCF+SQD+Q+LR+++ +ER  SD D+Y++LM LQDRNEKLFY+VL SD+EKFMPIVYT
Sbjct: 79   IPPCFLSQDVQLLRIMRYYERQQSDLDKYIILMTLQDRNEKLFYRVLTSDVEKFMPIVYT 138

Query: 447  PTVGLACQQYSLAFRKPRGLFISIHDRGHVASVLNAWPEDVIKAVVVTDGERILGLGDLG 626
            PTVGLACQ Y L FR+PRGLFI+IHD+GH+A++LN+WPED IKAVVVTDGERILGLGDLG
Sbjct: 139  PTVGLACQHYGLTFRRPRGLFITIHDKGHLATMLNSWPEDNIKAVVVTDGERILGLGDLG 198

Query: 627  CNGMGIPVGKLALYTACGGVNPQECLPVILDVGTENEELLKDPLYIGLRQRRVRGPEYDD 806
            C GMGIPVGKLALYTACGGVNPQ+CLPV+LDVGT NEELL+DPLYIGL+ +RV G  YDD
Sbjct: 199  CYGMGIPVGKLALYTACGGVNPQQCLPVLLDVGTNNEELLRDPLYIGLKHQRVHGKAYDD 258

Query: 807  FLDEFMEAVSSKYGMNCLIQFEDFANINAFRLLKKYQNQYCTFNDDIQGTASVAVAGILA 986
             LDEFM+AV+ K+G+NCLIQFEDFAN NAFRLL KY+N+YC FNDDIQGTASVAVAGILA
Sbjct: 259  LLDEFMQAVTDKFGINCLIQFEDFANANAFRLLNKYRNKYCMFNDDIQGTASVAVAGILA 318

Query: 987  ALRITKNKLSDQTILFQGAGEAALGIAHLIVMAMEKEGVPKEKAIKKIWLVDSKGLIVKG 1166
            ALRITKNKLS+   +FQGAGEAA+GIAHL+VMA+EKEGVPK +A +KIW+VDSKGLIVKG
Sbjct: 319  ALRITKNKLSNHVFVFQGAGEAAMGIAHLLVMALEKEGVPKAEATRKIWMVDSKGLIVKG 378

Query: 1167 RAALTNXXXXXXXXXXXMKNLEAIVQDIKPTALIGVAAIGGAFSEQILKDMAAFNERPII 1346
            R+ L +           + +LE +V+ +KPTA+IGVAAI GAF+EQIL+DMA+F+ERPII
Sbjct: 379  RSHLNHEKEMFAQDHPEVNSLEEVVRLVKPTAIIGVAAIAGAFTEQILRDMASFHERPII 438

Query: 1347 FALSNPTSKAECTAEQCYTLTQGRAIFASGSPFDPVTLPSGQTLYPGQGNNSYVFPGVAL 1526
            FALSNPTSKAECTAE+CY +T+GR IFASGSPF  VTL  G+T  PGQGNN+YVFPGVAL
Sbjct: 439  FALSNPTSKAECTAEKCYRVTEGRGIFASGSPFKSVTLEDGKTFIPGQGNNAYVFPGVAL 498

Query: 1527 GVVACGLRHITDKILLTTAEVIAQQVSDKHLEEGRLYPPLNTIRDVSLKIAEKIVRDAYQ 1706
            GV+A G+RHI D+I L TAE IAQ+VS++HL +GRLYPPL+TIRDVSL+IA K++  AY+
Sbjct: 499  GVIAGGIRHIPDEIFLLTAEQIAQEVSEQHLSQGRLYPPLSTIRDVSLRIAIKVLDYAYK 558

Query: 1707 EKTATIYPEPSNKEAFVRSQMYSTDYDQILPDGYSWPEEAQKIQT 1841
               A+ YPEP +KEAFVRS +Y+ DYD    D Y+WP+EA  +QT
Sbjct: 559  HNLASYYPEPKDKEAFVRSLVYTPDYDSFTLDSYTWPKEAMNVQT 603


>ref|NP_002387.1| malic enzyme 2, NAD(+)-dependent, mitochondrial [Homo sapiens]
          Length = 584

 Score =  645 bits (1664), Expect = 0.0
 Identities = 310/562 (55%), Positives = 404/562 (71%), Gaps = 3/562 (0%)
 Frame = +3

Query: 150  APRRRHTLQRGYAVTRIPHLNKDLAFTLEERQQLNIHGLLPPCFISQDIQVLRVIKNFER 329
            A R  H  ++G  +   P  NK +AFTL+ERQ L + GLLPP   +QDIQ LR  +N ++
Sbjct: 15   ACRHLHIKEKGKPLMLNPRTNKGMAFTLQERQMLGLQGLLPPKIETQDIQALRFHRNLKK 74

Query: 330  LNSDFDRYLLLMDLQDRNEKLFYKVLMSDIEKFMPIVYTPTVGLACQQYSLAFRKPRGLF 509
            + S  ++Y+ +M +Q+RNEKLFY++L  DIE  MPIVYTPTVGLAC QY   FR+P+GLF
Sbjct: 75   MTSPLEKYIYIMGIQERNEKLFYRILQDDIESLMPIVYTPTVGLACSQYGHIFRRPKGLF 134

Query: 510  ISIHDRGHVASVLNAWPEDVIKAVVVTDGERILGLGDLGCNGMGIPVGKLALYTACGGVN 689
            ISI DRGHV S+++ WPE+ +KAVVVTDGERILGLGDLG  GMGIPVGKL LYTAC G+ 
Sbjct: 135  ISISDRGHVRSIVDNWPENHVKAVVVTDGERILGLGDLGVYGMGIPVGKLCLYTACAGIR 194

Query: 690  PQECLPVILDVGTENEELLKDPLYIGLRQRRVRGPEYDDFLDEFMEAVSSKYGMNCLIQF 869
            P  CLPV +DVGT+N  LLKDP Y+GL Q+R R  +YDD +DEFM+A++ +YG N LIQF
Sbjct: 195  PDRCLPVCIDVGTDNIALLKDPFYMGLYQKRDRTQQYDDLIDEFMKAITDRYGRNTLIQF 254

Query: 870  EDFANINAFRLLKKYQNQYCTFNDDIQGTASVAVAGILAALRITKNKLSDQTILFQGAGE 1049
            EDF N NAFR L+KY+ +YCTFNDDIQGTA+VA+AG+LAA ++    +S+  ILF GAGE
Sbjct: 255  EDFGNHNAFRFLRKYREKYCTFNDDIQGTAAVALAGLLAAQKVISKPISEHKILFLGAGE 314

Query: 1050 AALGIAHLIVMAMEKEGVPKEKAIKKIWLVDSKGLIVKGRAALTNXX---XXXXXXXXXM 1220
            AALGIA+LIVM+M + G+ +++A KKIW+ D  GL+VKGR A  +               
Sbjct: 315  AALGIANLIVMSMVENGLSEQEAQKKIWMFDKYGLLVKGRKAKIDSYQEPFTHSAPESIP 374

Query: 1221 KNLEAIVQDIKPTALIGVAAIGGAFSEQILKDMAAFNERPIIFALSNPTSKAECTAEQCY 1400
               E  V  +KP+ +IGVA  G  F+  +++ MA+ NERP+IFALSNPT++AECTAE+ Y
Sbjct: 375  DTFEDAVNILKPSTIIGVAGAGRLFTPDVIRAMASINERPVIFALSNPTAQAECTAEEAY 434

Query: 1401 TLTQGRAIFASGSPFDPVTLPSGQTLYPGQGNNSYVFPGVALGVVACGLRHITDKILLTT 1580
            TLT+GR +FASGSPF PV L  G+   PGQGNN Y+FPGVAL V+ C  RHI+D + L  
Sbjct: 435  TLTEGRCLFASGSPFGPVKLTDGRVFTPGQGNNVYIFPGVALAVILCNTRHISDSVFLEA 494

Query: 1581 AEVIAQQVSDKHLEEGRLYPPLNTIRDVSLKIAEKIVRDAYQEKTATIYPEPSNKEAFVR 1760
            A+ +  Q++D+ L +GRLYPPL  I++VS+ IA K+    Y  K A  YPEP +K  +V+
Sbjct: 495  AKALTSQLTDEELAQGRLYPPLANIQEVSINIAIKVTEYLYANKMAFRYPEPEDKAKYVK 554

Query: 1761 SQMYSTDYDQILPDGYSWPEEA 1826
             + + ++YD +LPD Y WPE A
Sbjct: 555  ERTWRSEYDSLLPDVYEWPESA 576


>ref|XP_934770.1| PREDICTED: similar to NAD-dependent malic enzyme, mitochondrial
           precursor (NAD-ME) (Malic enzyme 2) [Homo sapiens]
          Length = 196

 Score =  239 bits (610), Expect = 7e-63
 Identities = 112/196 (57%), Positives = 144/196 (73%)
 Frame = +3

Query: 330 LNSDFDRYLLLMDLQDRNEKLFYKVLMSDIEKFMPIVYTPTVGLACQQYSLAFRKPRGLF 509
           + S  + Y+ +M +Q+RN+KLFY++L  D E  MPI YTPTVGL C Q    FR+P+GLF
Sbjct: 1   MTSPSENYIYIMGIQERNDKLFYRILQDDTESLMPIAYTPTVGLVCSQCGHLFRRPKGLF 60

Query: 510 ISIHDRGHVASVLNAWPEDVIKAVVVTDGERILGLGDLGCNGMGIPVGKLALYTACGGVN 689
           ISI DRGHV S+++ WPE+ +KAV+VTDGERILG GDLG  GMGIPVGK+ LYT C G+ 
Sbjct: 61  ISISDRGHVRSIVDKWPENHVKAVLVTDGERILGHGDLGVYGMGIPVGKICLYTVCPGIW 120

Query: 690 PQECLPVILDVGTENEELLKDPLYIGLRQRRVRGPEYDDFLDEFMEAVSSKYGMNCLIQF 869
           P  CL V +DVG +N  LLK   Y+GL Q+R R  + DD +DEFM+A++ +YG N L+QF
Sbjct: 121 PDRCLLVCIDVGADNIALLKGTFYMGLYQKRDRTQQSDDPIDEFMKAITDRYGWNTLLQF 180

Query: 870 EDFANINAFRLLKKYQ 917
           E F + NAFR L+KYQ
Sbjct: 181 EGFGHHNAFRFLRKYQ 196


>ref|XP_944182.1| PREDICTED: similar to NAD-dependent malic enzyme, mitochondrial
           precursor (NAD-ME) (Malic enzyme 2) [Homo sapiens]
          Length = 196

 Score =  239 bits (610), Expect = 7e-63
 Identities = 112/196 (57%), Positives = 144/196 (73%)
 Frame = +3

Query: 330 LNSDFDRYLLLMDLQDRNEKLFYKVLMSDIEKFMPIVYTPTVGLACQQYSLAFRKPRGLF 509
           + S  + Y+ +M +Q+RN+KLFY++L  D E  MPI YTPTVGL C Q    FR+P+GLF
Sbjct: 1   MTSPSENYIYIMGIQERNDKLFYRILQDDTESLMPIAYTPTVGLVCSQCGHLFRRPKGLF 60

Query: 510 ISIHDRGHVASVLNAWPEDVIKAVVVTDGERILGLGDLGCNGMGIPVGKLALYTACGGVN 689
           ISI DRGHV S+++ WPE+ +KAV+VTDGERILG GDLG  GMGIPVGK+ LYT C G+ 
Sbjct: 61  ISISDRGHVRSIVDKWPENHVKAVLVTDGERILGHGDLGVYGMGIPVGKICLYTVCPGIW 120

Query: 690 PQECLPVILDVGTENEELLKDPLYIGLRQRRVRGPEYDDFLDEFMEAVSSKYGMNCLIQF 869
           P  CL V +DVG +N  LLK   Y+GL Q+R R  + DD +DEFM+A++ +YG N L+QF
Sbjct: 121 PDRCLLVCIDVGADNIALLKGTFYMGLYQKRDRTQQSDDPIDEFMKAITDRYGWNTLLQF 180

Query: 870 EDFANINAFRLLKKYQ 917
           E F + NAFR L+KYQ
Sbjct: 181 EGFGHHNAFRFLRKYQ 196


  Database: RefSeqHP
    Posted date:  Aug 2, 2006 12:57 AM
  Number of letters in database: 17,774,539
  Number of sequences in database:  39,411
  
Lambda     K      H
   0.318    0.134    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 75,758,260
Number of Sequences: 39411
Number of extensions: 1915497
Number of successful extensions: 5801
Number of sequences better than 1.0e-05: 6
Number of HSP's better than  0.0 without gapping: 4948
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5790
length of database: 17,774,539
effective HSP length: 109
effective length of database: 13,478,740
effective search space used: 8451169980
frameshift window, decay const: 40,  0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)

Search to RefSeqMP

BLASTX 2.2.10 [Oct-19-2004]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= LVRM1_0151_G04
         (2212 letters)

Database: RefSeqMP 
           45,328 sequences; 21,768,885 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

Alignment   gi|NP_032641.1| malic enzyme, supernatant [Mus musculus]            1004   0.0  
Alignment   gi|XP_001004685.1| PREDICTED: similar to NADP-dependent malic e...   967   0.0  
Alignment   gi|XP_001004679.1| PREDICTED: similar to NADP-dependent malic e...   945   0.0  
Alignment   gi|NP_852072.1| malic enzyme 3, NADP(+)-dependent, mitochondria...   832   0.0  
Alignment   gi|XP_001004683.1| PREDICTED: similar to NADP-dependent malic e...   696   0.0  
Alignment   gi|NP_663469.1| malic enzyme 2, NAD(+)-dependent, mitochondrial...   640   0.0  
Alignment   gi|XP_001004682.1| PREDICTED: similar to NADP-dependent malic e...   422   e-118
Alignment   gi|XP_001004303.1| PREDICTED: similar to NADP-dependent malic e...   114   3e-25

>ref|NP_032641.1| malic enzyme, supernatant [Mus musculus]
          Length = 572

 Score = 1004 bits (2595), Expect = 0.0
 Identities = 493/571 (86%), Positives = 529/571 (92%)
 Frame = +3

Query: 138  MEPRAPRRRHTLQRGYAVTRIPHLNKDLAFTLEERQQLNIHGLLPPCFISQDIQVLRVIK 317
            MEPRAPRRRHT QRGY +TR PHLNKDLAFTLEERQQLNIHGLLPPC ISQ++QVLR+IK
Sbjct: 1    MEPRAPRRRHTHQRGYLLTRDPHLNKDLAFTLEERQQLNIHGLLPPCIISQELQVLRIIK 60

Query: 318  NFERLNSDFDRYLLLMDLQDRNEKLFYKVLMSDIEKFMPIVYTPTVGLACQQYSLAFRKP 497
            NFERLNSDFDRYLLLMDLQDRNEKLFY VLMSD+EKFMPIVYTPTVGLACQQYSLAFRKP
Sbjct: 61   NFERLNSDFDRYLLLMDLQDRNEKLFYSVLMSDVEKFMPIVYTPTVGLACQQYSLAFRKP 120

Query: 498  RGLFISIHDRGHVASVLNAWPEDVIKAVVVTDGERILGLGDLGCNGMGIPVGKLALYTAC 677
            RGLFISIHD+GH+ASVLNAWPEDV+KA+VVTDGERILGLGDLGCNGMGIPVGKLALYTAC
Sbjct: 121  RGLFISIHDKGHIASVLNAWPEDVVKAIVVTDGERILGLGDLGCNGMGIPVGKLALYTAC 180

Query: 678  GGVNPQECLPVILDVGTENEELLKDPLYIGLRQRRVRGPEYDDFLDEFMEAVSSKYGMNC 857
            GGVNPQ+CLP+ LDVGTENEELLKDPLYIGLR RRVRGPEYD FLDEFMEA SSKYGMNC
Sbjct: 181  GGVNPQQCLPITLDVGTENEELLKDPLYIGLRHRRVRGPEYDAFLDEFMEAASSKYGMNC 240

Query: 858  LIQFEDFANINAFRLLKKYQNQYCTFNDDIQGTASVAVAGILAALRITKNKLSDQTILFQ 1037
            LIQFEDFAN NAFRLL KY+N+YCTFNDDIQGTASVAVAG+LAALRITKNKLSDQT+LFQ
Sbjct: 241  LIQFEDFANRNAFRLLNKYRNKYCTFNDDIQGTASVAVAGLLAALRITKNKLSDQTVLFQ 300

Query: 1038 GAGEAALGIAHLIVMAMEKEGVPKEKAIKKIWLVDSKGLIVKGRAALTNXXXXXXXXXXX 1217
            GAGEAALGIAHL+VMAMEKEG+ KE A KKIWLVDSKGLIVKGRA+LT            
Sbjct: 301  GAGEAALGIAHLVVMAMEKEGLSKENARKKIWLVDSKGLIVKGRASLTEEKEVFAHEHEE 360

Query: 1218 MKNLEAIVQDIKPTALIGVAAIGGAFSEQILKDMAAFNERPIIFALSNPTSKAECTAEQC 1397
            MKNLEAIVQ IKPTALIGVAAIGGAF+EQILKDMAAFNERPIIFALS+PTSKAEC+A++C
Sbjct: 361  MKNLEAIVQKIKPTALIGVAAIGGAFTEQILKDMAAFNERPIIFALSSPTSKAECSADEC 420

Query: 1398 YTLTQGRAIFASGSPFDPVTLPSGQTLYPGQGNNSYVFPGVALGVVACGLRHITDKILLT 1577
            Y +T+GRAIFASGSPFDPVTLP G+TL+PGQGNNSYVFPGVALGVVACGLRHI DK+ LT
Sbjct: 421  YKVTKGRAIFASGSPFDPVTLPDGRTLFPGQGNNSYVFPGVALGVVACGLRHIDDKVFLT 480

Query: 1578 TAEVIAQQVSDKHLEEGRLYPPLNTIRDVSLKIAEKIVRDAYQEKTATIYPEPSNKEAFV 1757
            T EVI+QQVSDKHL+EGRLYPPLNTIR VSLKIA KIV+DAY+EK AT+YPEP NKE FV
Sbjct: 481  TREVISQQVSDKHLQEGRLYPPLNTIRGVSLKIAVKIVQDAYKEKMATVYPEPQNKEEFV 540

Query: 1758 RSQMYSTDYDQILPDGYSWPEEAQKIQTKLD 1850
             SQMYST+YDQILPD Y WP E QKIQTK++
Sbjct: 541  SSQMYSTNYDQILPDCYPWPAEVQKIQTKVN 571


>ref|XP_001004685.1| PREDICTED: similar to NADP-dependent malic enzyme (NADP-ME) (Malic
            enzyme 1) isoform 4 [Mus musculus]
          Length = 552

 Score =  967 bits (2501), Expect = 0.0
 Identities = 476/546 (87%), Positives = 509/546 (93%)
 Frame = +3

Query: 213  KDLAFTLEERQQLNIHGLLPPCFISQDIQVLRVIKNFERLNSDFDRYLLLMDLQDRNEKL 392
            +DLAFTLEERQQLNIHGLLPPC ISQ++QVLR+IKNFERLNSDFDRYLLLMDLQDRNEKL
Sbjct: 6    EDLAFTLEERQQLNIHGLLPPCIISQELQVLRIIKNFERLNSDFDRYLLLMDLQDRNEKL 65

Query: 393  FYKVLMSDIEKFMPIVYTPTVGLACQQYSLAFRKPRGLFISIHDRGHVASVLNAWPEDVI 572
            FY VLMSD+EKFMPIVYTPTVGLACQQYSLAFRKPRGLFISIHD+GH+ASVLNAWPEDV+
Sbjct: 66   FYSVLMSDVEKFMPIVYTPTVGLACQQYSLAFRKPRGLFISIHDKGHIASVLNAWPEDVV 125

Query: 573  KAVVVTDGERILGLGDLGCNGMGIPVGKLALYTACGGVNPQECLPVILDVGTENEELLKD 752
            KA+VVTDGERILGLGDLGCNGMGIPVGKLALYTACGGVNPQ+CLP+ LDVGTENEELLKD
Sbjct: 126  KAIVVTDGERILGLGDLGCNGMGIPVGKLALYTACGGVNPQQCLPITLDVGTENEELLKD 185

Query: 753  PLYIGLRQRRVRGPEYDDFLDEFMEAVSSKYGMNCLIQFEDFANINAFRLLKKYQNQYCT 932
            PLYIGLR RRVRGPEYD FLDEFMEA SSKYGMNCLIQFEDFAN NAFRLL KY+N+YCT
Sbjct: 186  PLYIGLRHRRVRGPEYDAFLDEFMEAASSKYGMNCLIQFEDFANRNAFRLLNKYRNKYCT 245

Query: 933  FNDDIQGTASVAVAGILAALRITKNKLSDQTILFQGAGEAALGIAHLIVMAMEKEGVPKE 1112
            FNDDIQGTASVAVAG+LAALRITKNKLSDQT+LFQGAGEAALGIAHL+VMAMEKEG+ KE
Sbjct: 246  FNDDIQGTASVAVAGLLAALRITKNKLSDQTVLFQGAGEAALGIAHLVVMAMEKEGLSKE 305

Query: 1113 KAIKKIWLVDSKGLIVKGRAALTNXXXXXXXXXXXMKNLEAIVQDIKPTALIGVAAIGGA 1292
             A KKIWLVDSKGLIVKGRA+LT            MKNLEAIVQ IKPTALIGVAAIGGA
Sbjct: 306  NARKKIWLVDSKGLIVKGRASLTEEKEVFAHEHEEMKNLEAIVQKIKPTALIGVAAIGGA 365

Query: 1293 FSEQILKDMAAFNERPIIFALSNPTSKAECTAEQCYTLTQGRAIFASGSPFDPVTLPSGQ 1472
            F+EQILKDMAAFNERPIIFALSNPTSKAEC+AEQCY +T+GRAIFASGSPFDPVTLP G+
Sbjct: 366  FTEQILKDMAAFNERPIIFALSNPTSKAECSAEQCYKVTKGRAIFASGSPFDPVTLPDGR 425

Query: 1473 TLYPGQGNNSYVFPGVALGVVACGLRHITDKILLTTAEVIAQQVSDKHLEEGRLYPPLNT 1652
            TL+PGQGNNSYVFPGVALGVVACGLRHI DK+ LTTAEVI+QQVSDKHL+EGRLYPPLNT
Sbjct: 426  TLFPGQGNNSYVFPGVALGVVACGLRHIDDKVFLTTAEVISQQVSDKHLQEGRLYPPLNT 485

Query: 1653 IRDVSLKIAEKIVRDAYQEKTATIYPEPSNKEAFVRSQMYSTDYDQILPDGYSWPEEAQK 1832
            IRDVSLKIA KIV+DAY+EK AT+YPEP NKE FV SQMYST+YDQILPD Y WP E QK
Sbjct: 486  IRDVSLKIAVKIVQDAYKEKMATVYPEPQNKEEFVSSQMYSTNYDQILPDCYPWPAEVQK 545

Query: 1833 IQTKLD 1850
            IQTK++
Sbjct: 546  IQTKVN 551


>ref|XP_001004679.1| PREDICTED: similar to NADP-dependent malic enzyme (NADP-ME) (Malic
            enzyme 1) isoform 1 [Mus musculus]
          Length = 554

 Score =  945 bits (2442), Expect = 0.0
 Identities = 468/548 (85%), Positives = 502/548 (91%), Gaps = 2/548 (0%)
 Frame = +3

Query: 213  KDLAFTLEERQQLNIHGLLPPCFISQDIQVLRVIKNFERLNSDFDRYLLLMDLQDRNEKL 392
            +DLAFTLEERQQLNIHGLLPPC ISQ++QVLR+IKNFERLNSDFDRYLLLMDLQDRNEKL
Sbjct: 6    EDLAFTLEERQQLNIHGLLPPCIISQELQVLRIIKNFERLNSDFDRYLLLMDLQDRNEKL 65

Query: 393  FYKVLMSDIEKFMPIVYTPTVGLACQQYSLAFRKPRGLFISIHDRGHVASVLNAWPEDVI 572
            FY VLMSD+EKFMPIVYTPTVGLACQQYSLAFRKPRGLFISIHD+GH+ASVLNAWPEDV+
Sbjct: 66   FYSVLMSDVEKFMPIVYTPTVGLACQQYSLAFRKPRGLFISIHDKGHIASVLNAWPEDVV 125

Query: 573  KAVVVTDGERILGLGDLGCNGMGIPVGKLALYTACGGVNPQECLPVILDVGTENEELLKD 752
            KA+VVTDGERILGLGDLGCNGMGIPVGKLALYTACGGVNPQ+CLP+ LDVGTENEELLKD
Sbjct: 126  KAIVVTDGERILGLGDLGCNGMGIPVGKLALYTACGGVNPQQCLPITLDVGTENEELLKD 185

Query: 753  PLYIGLRQRRVRGPEYDDFLDEFMEAVSSKYGMNCLIQFEDFANINAFRLLKKYQNQYCT 932
            PLYIGLR RRVRGPEYD FLDEFMEA SSKYGMNCLIQFEDFAN NAFRLL KY+N+YCT
Sbjct: 186  PLYIGLRHRRVRGPEYDAFLDEFMEAASSKYGMNCLIQFEDFANRNAFRLLNKYRNKYCT 245

Query: 933  FNDDIQGTASVAVAGILAALRITKNKLSDQTILFQGAGEAALGIAHLIVMAMEKEGVPKE 1112
            FNDDIQGTASVAVAG+LAALRITKNKLSDQT+LFQGAGEAALGIAHL+VMAMEKEG+ KE
Sbjct: 246  FNDDIQGTASVAVAGLLAALRITKNKLSDQTVLFQGAGEAALGIAHLVVMAMEKEGLSKE 305

Query: 1113 KAIKKIWLVDSKGLIVKGRAALTNXX--XXXXXXXXXMKNLEAIVQDIKPTALIGVAAIG 1286
             A KKIWLVDSKGLIVK R  +T                NLEAIVQ IKPTALIGVAAIG
Sbjct: 306  NARKKIWLVDSKGLIVKVRKKVTTYLKPYTGAAPDSLHSNLEAIVQKIKPTALIGVAAIG 365

Query: 1287 GAFSEQILKDMAAFNERPIIFALSNPTSKAECTAEQCYTLTQGRAIFASGSPFDPVTLPS 1466
            GAF+EQILKDMAAFNERPIIFALSNPTSKAEC+AEQCY +T+GRAIFASGSPFDPVTLP 
Sbjct: 366  GAFTEQILKDMAAFNERPIIFALSNPTSKAECSAEQCYKVTKGRAIFASGSPFDPVTLPD 425

Query: 1467 GQTLYPGQGNNSYVFPGVALGVVACGLRHITDKILLTTAEVIAQQVSDKHLEEGRLYPPL 1646
            G+TL+PGQGNNSYVFPGVALGVVACGLRHI DK+ LTTAEVI+QQVSDKHL+EGRLYPPL
Sbjct: 426  GRTLFPGQGNNSYVFPGVALGVVACGLRHIDDKVFLTTAEVISQQVSDKHLQEGRLYPPL 485

Query: 1647 NTIRDVSLKIAEKIVRDAYQEKTATIYPEPSNKEAFVRSQMYSTDYDQILPDGYSWPEEA 1826
            NTIRDVSLKIA K+ + AY+EK AT+YPEP NKE FV SQMYST+YDQILPD Y WP E 
Sbjct: 486  NTIRDVSLKIAVKVRQYAYKEKMATVYPEPQNKEEFVSSQMYSTNYDQILPDCYPWPAEV 545

Query: 1827 QKIQTKLD 1850
            QKIQTK++
Sbjct: 546  QKIQTKVN 553


>ref|NP_852072.1| malic enzyme 3, NADP(+)-dependent, mitochondrial [Mus musculus]
          Length = 604

 Score =  832 bits (2148), Expect = 0.0
 Identities = 404/583 (69%), Positives = 487/583 (83%)
 Frame = +3

Query: 90   SIRPLSPVPPRQRQPAMEPRAPRRRHTLQRGYAVTRIPHLNKDLAFTLEERQQLNIHGLL 269
            S+R  +P  P Q   + +   PR     +RGY VTR PHLNK +AFTLEER QL IHGL+
Sbjct: 21   SLRRQAPSAPAQGCHS-KSGPPRPVPLKKRGYDVTRNPHLNKGMAFTLEERLQLGIHGLI 79

Query: 270  PPCFISQDIQVLRVIKNFERLNSDFDRYLLLMDLQDRNEKLFYKVLMSDIEKFMPIVYTP 449
            PPCF+SQD+Q+LR+++ +E   SD D+Y++LM  QDRNEKLFY+VL SD+EKFMPIVYTP
Sbjct: 80   PPCFLSQDVQLLRIMRYYENQQSDLDKYIILMTHQDRNEKLFYRVLTSDVEKFMPIVYTP 139

Query: 450  TVGLACQQYSLAFRKPRGLFISIHDRGHVASVLNAWPEDVIKAVVVTDGERILGLGDLGC 629
            TVGLACQ Y L FR+PRGLFI+IHD+GH+A++LN+WPED IKAVVVTDGERILGLGDLGC
Sbjct: 140  TVGLACQHYGLTFRRPRGLFITIHDKGHIATMLNSWPEDNIKAVVVTDGERILGLGDLGC 199

Query: 630  NGMGIPVGKLALYTACGGVNPQECLPVILDVGTENEELLKDPLYIGLRQRRVRGPEYDDF 809
             GMGIPVGKLALYTACGGVNPQ+CLPV+LDVGT NEELL+DPLYIGL+ +RVRG EYDD 
Sbjct: 200  YGMGIPVGKLALYTACGGVNPQQCLPVLLDVGTNNEELLRDPLYIGLKHQRVRGEEYDDL 259

Query: 810  LDEFMEAVSSKYGMNCLIQFEDFANINAFRLLKKYQNQYCTFNDDIQGTASVAVAGILAA 989
            LDEFM+AV+ K+G+NCLIQFEDFAN NAFRLL KY+N+YC FNDDIQGTASVAVAGILAA
Sbjct: 260  LDEFMQAVTDKFGINCLIQFEDFANANAFRLLNKYRNKYCMFNDDIQGTASVAVAGILAA 319

Query: 990  LRITKNKLSDQTILFQGAGEAALGIAHLIVMAMEKEGVPKEKAIKKIWLVDSKGLIVKGR 1169
            LRITKN+LS+   +FQGA EAA+GIAHL+VMA+EKEG+PK +AIKKIW+VDSKGLIVKGR
Sbjct: 320  LRITKNRLSNHVFVFQGADEAAMGIAHLLVMALEKEGIPKTEAIKKIWMVDSKGLIVKGR 379

Query: 1170 AALTNXXXXXXXXXXXMKNLEAIVQDIKPTALIGVAAIGGAFSEQILKDMAAFNERPIIF 1349
            + L +           + +LE +V+ +KPTA+IGVAAI GAF+EQIL+DMA+F+ERPI+F
Sbjct: 380  SHLNHEKEMFAQDHPEVNSLEEVVRLVKPTAIIGVAAIAGAFTEQILRDMASFHERPIVF 439

Query: 1350 ALSNPTSKAECTAEQCYTLTQGRAIFASGSPFDPVTLPSGQTLYPGQGNNSYVFPGVALG 1529
            ALSNPTSKAECTAE+CY +T+GR IFASGSPF  VTL  G+T  PGQGNN+YVFPGVALG
Sbjct: 440  ALSNPTSKAECTAEKCYRVTEGRGIFASGSPFKSVTLEDGRTFTPGQGNNAYVFPGVALG 499

Query: 1530 VVACGLRHITDKILLTTAEVIAQQVSDKHLEEGRLYPPLNTIRDVSLKIAEKIVRDAYQE 1709
            V+A G+RHI D+I L TAE IAQ+VS++HL +GRLYPPL+TIRDVSL+IA K++  AY+ 
Sbjct: 500  VIAGGIRHIPDEIFLLTAEQIAQEVSEQHLSQGRLYPPLSTIRDVSLRIAVKVLDYAYKH 559

Query: 1710 KTATIYPEPSNKEAFVRSQMYSTDYDQILPDGYSWPEEAQKIQ 1838
              A+ YPEP +KEAFV+S +Y+ DYD    D YSWP+EA  +Q
Sbjct: 560  NLASYYPEPKDKEAFVKSLIYTPDYDSFSLDTYSWPKEAMSVQ 602


>ref|XP_001004683.1| PREDICTED: similar to NADP-dependent malic enzyme (NADP-ME) (Malic
            enzyme 1) isoform 3 [Mus musculus]
          Length = 406

 Score =  696 bits (1797), Expect = 0.0
 Identities = 346/405 (85%), Positives = 370/405 (91%)
 Frame = +3

Query: 636  MGIPVGKLALYTACGGVNPQECLPVILDVGTENEELLKDPLYIGLRQRRVRGPEYDDFLD 815
            MGIPVGKLALYTACGGVNPQ+CLP+ LDVGTENEELLKDPLYIGLR RRVRGPEYD FLD
Sbjct: 1    MGIPVGKLALYTACGGVNPQQCLPITLDVGTENEELLKDPLYIGLRHRRVRGPEYDAFLD 60

Query: 816  EFMEAVSSKYGMNCLIQFEDFANINAFRLLKKYQNQYCTFNDDIQGTASVAVAGILAALR 995
            EFMEA SSKYGMNCLIQFEDFAN NAFRLL KY+N+YCTFNDDIQGTASVAVAG+LAALR
Sbjct: 61   EFMEAASSKYGMNCLIQFEDFANRNAFRLLNKYRNKYCTFNDDIQGTASVAVAGLLAALR 120

Query: 996  ITKNKLSDQTILFQGAGEAALGIAHLIVMAMEKEGVPKEKAIKKIWLVDSKGLIVKGRAA 1175
            ITKNKLSDQT+LFQGAGEAALGIAHL+VMAMEKEG+ KE A KKIWLVDSKGLIVKGRA+
Sbjct: 121  ITKNKLSDQTVLFQGAGEAALGIAHLVVMAMEKEGLSKENARKKIWLVDSKGLIVKGRAS 180

Query: 1176 LTNXXXXXXXXXXXMKNLEAIVQDIKPTALIGVAAIGGAFSEQILKDMAAFNERPIIFAL 1355
            LT            MKNLEAIVQ IKPTALIGVAAIGGAF+EQILKDMAAFNERPIIFAL
Sbjct: 181  LTEEKEVFAHEHEEMKNLEAIVQKIKPTALIGVAAIGGAFTEQILKDMAAFNERPIIFAL 240

Query: 1356 SNPTSKAECTAEQCYTLTQGRAIFASGSPFDPVTLPSGQTLYPGQGNNSYVFPGVALGVV 1535
            SNPTSKAEC+AEQCY +T+GRAIFASGSPFDPVTLP G+TL+PGQGNNSYVFPGVALGVV
Sbjct: 241  SNPTSKAECSAEQCYKVTKGRAIFASGSPFDPVTLPDGRTLFPGQGNNSYVFPGVALGVV 300

Query: 1536 ACGLRHITDKILLTTAEVIAQQVSDKHLEEGRLYPPLNTIRDVSLKIAEKIVRDAYQEKT 1715
            ACGLRHI DK+ LTTAEVI+QQVSDKHL+EGRLYPPLNTIRDVSLKIA KIV+DAY+EK 
Sbjct: 301  ACGLRHIDDKVFLTTAEVISQQVSDKHLQEGRLYPPLNTIRDVSLKIAVKIVQDAYKEKM 360

Query: 1716 ATIYPEPSNKEAFVRSQMYSTDYDQILPDGYSWPEEAQKIQTKLD 1850
            AT+YPEP NKE FV SQMYST+YDQILPD Y WP E QKIQTK++
Sbjct: 361  ATVYPEPQNKEEFVSSQMYSTNYDQILPDCYPWPAEVQKIQTKVN 405


>ref|NP_663469.1| malic enzyme 2, NAD(+)-dependent, mitochondrial [Mus musculus]
          Length = 589

 Score =  640 bits (1651), Expect = 0.0
 Identities = 310/560 (55%), Positives = 403/560 (71%), Gaps = 3/560 (0%)
 Frame = +3

Query: 156  RRRHTLQRGYAVTRIPHLNKDLAFTLEERQQLNIHGLLPPCFISQDIQVLRVIKNFERLN 335
            RR H  ++G  +   P  NK +AFTL+ERQ L + GLLPP   +QDIQ LR  +N +++ 
Sbjct: 17   RRVHLKEKGKPLMLNPRTNKGMAFTLQERQMLGLQGLLPPKIETQDIQALRFHRNLKKMT 76

Query: 336  SDFDRYLLLMDLQDRNEKLFYKVLMSDIEKFMPIVYTPTVGLACQQYSLAFRKPRGLFIS 515
            S  ++Y+ +M +Q+RNEKLFY++L  DIE  MPIVYTPTVGLAC QY   FR+P+GLFIS
Sbjct: 77   SPLEKYIYIMGIQERNEKLFYRILQDDIESLMPIVYTPTVGLACCQYGHIFRRPKGLFIS 136

Query: 516  IHDRGHVASVLNAWPEDVIKAVVVTDGERILGLGDLGCNGMGIPVGKLALYTACGGVNPQ 695
            I DRGHV S+++ WPE+ +KAVVVTDGERILGLGDLG  GMGIPVGKL LYTAC G+ P+
Sbjct: 137  ISDRGHVRSIVDNWPENHVKAVVVTDGERILGLGDLGVYGMGIPVGKLCLYTACAGIQPE 196

Query: 696  ECLPVILDVGTENEELLKDPLYIGLRQRRVRGPEYDDFLDEFMEAVSSKYGMNCLIQFED 875
            +CLPV +DVGT+N  LLKDP Y+GL Q+R R   YDD +DEFM+A++ +YG N LIQFED
Sbjct: 197  KCLPVCIDVGTDNMALLKDPFYMGLYQKRDRSQLYDDLMDEFMKAITDRYGRNTLIQFED 256

Query: 876  FANINAFRLLKKYQNQYCTFNDDIQGTASVAVAGILAALRITKNKLSDQTILFQGAGEAA 1055
            F N NAFR L+KYQ +YCTFNDDIQGTA+VA++G+LAA R+    +S+  ILF GAGEAA
Sbjct: 257  FGNHNAFRFLRKYQQKYCTFNDDIQGTAAVALSGLLAAQRVINKPVSEHKILFLGAGEAA 316

Query: 1056 LGIAHLIVMAMEKEGVPKEKAIKKIWLVDSKGLIVKGRAALTNXX---XXXXXXXXXMKN 1226
            LGIA+LIV++M + G+ +E+A +KIW+ D  GL+VKGR A  +                 
Sbjct: 317  LGIANLIVLSMVESGLSEEEAQRKIWMFDKSGLLVKGRTASIDSNQEPYAHAAPESIPAT 376

Query: 1227 LEAIVQDIKPTALIGVAAIGGAFSEQILKDMAAFNERPIIFALSNPTSKAECTAEQCYTL 1406
             E  V  +KP+ +IGVA  G  F+  ++K MA+ NERPIIFALSNPT++AECTAE  YTL
Sbjct: 377  FEDAVNKLKPSVIIGVAGAGPLFTHGVIKAMASINERPIIFALSNPTAQAECTAEDAYTL 436

Query: 1407 TQGRAIFASGSPFDPVTLPSGQTLYPGQGNNSYVFPGVALGVVACGLRHITDKILLTTAE 1586
            T+GR +FASGSPF+PV L  G+   PGQGNN+Y+FPGVAL V+ C  RHI+D + L  A+
Sbjct: 437  TEGRCLFASGSPFEPVKLQDGRVFTPGQGNNAYIFPGVALAVILCEARHISDTVFLEAAK 496

Query: 1587 VIAQQVSDKHLEEGRLYPPLNTIRDVSLKIAEKIVRDAYQEKTATIYPEPSNKEAFVRSQ 1766
             +  Q++D  L +GRLYP L  I++VS  IA K+    Y  K A  YPEP +K  +VR +
Sbjct: 497  ALTTQLTDAELAQGRLYPSLANIQEVSANIAIKLAEYLYANKMAFRYPEPEDKARYVRER 556

Query: 1767 MYSTDYDQILPDGYSWPEEA 1826
            ++ ++Y  +LPD Y WPE +
Sbjct: 557  IWRSNYVSLLPDVYDWPESS 576


>ref|XP_001004682.1| PREDICTED: similar to NADP-dependent malic enzyme (NADP-ME) (Malic
            enzyme 1) isoform 2 [Mus musculus]
          Length = 258

 Score =  422 bits (1085), Expect = e-118
 Identities = 211/257 (82%), Positives = 228/257 (88%)
 Frame = +3

Query: 1080 MAMEKEGVPKEKAIKKIWLVDSKGLIVKGRAALTNXXXXXXXXXXXMKNLEAIVQDIKPT 1259
            MAMEKEG+ KE A KKIWLVDSKGLIVKGRA+LT            MKNLEAIVQ IKPT
Sbjct: 1    MAMEKEGLSKENARKKIWLVDSKGLIVKGRASLTEEKEVFAHEHEEMKNLEAIVQKIKPT 60

Query: 1260 ALIGVAAIGGAFSEQILKDMAAFNERPIIFALSNPTSKAECTAEQCYTLTQGRAIFASGS 1439
            ALIGVAAIGGAF+EQILKDMAAFNERPIIFALSNPTSKAEC+AEQCY +T+GRAIFASGS
Sbjct: 61   ALIGVAAIGGAFTEQILKDMAAFNERPIIFALSNPTSKAECSAEQCYKVTKGRAIFASGS 120

Query: 1440 PFDPVTLPSGQTLYPGQGNNSYVFPGVALGVVACGLRHITDKILLTTAEVIAQQVSDKHL 1619
            PFDPVTLP G+TL+PGQGNNSYVFPGVALGVVACGLRHI DK+ LTTAEVI+QQVSDKHL
Sbjct: 121  PFDPVTLPDGRTLFPGQGNNSYVFPGVALGVVACGLRHIDDKVFLTTAEVISQQVSDKHL 180

Query: 1620 EEGRLYPPLNTIRDVSLKIAEKIVRDAYQEKTATIYPEPSNKEAFVRSQMYSTDYDQILP 1799
            +EGRLYPPLNTIRDVSLKIA KIV+DAY+EK AT+YPEP NKE FV SQMYST+YDQILP
Sbjct: 181  QEGRLYPPLNTIRDVSLKIAVKIVQDAYKEKMATVYPEPQNKEEFVSSQMYSTNYDQILP 240

Query: 1800 DGYSWPEEAQKIQTKLD 1850
            D Y WP E QKIQTK++
Sbjct: 241  DCYPWPAEVQKIQTKVN 257


>ref|XP_001004303.1| PREDICTED: similar to NADP-dependent malic enzyme (NADP-ME) (Malic
            enzyme 1) [Mus musculus]
          Length = 66

 Score =  114 bits (286), Expect = 3e-25
 Identities = 53/60 (88%), Positives = 57/60 (95%)
 Frame = +3

Query: 1413 GRAIFASGSPFDPVTLPSGQTLYPGQGNNSYVFPGVALGVVACGLRHITDKILLTTAEVI 1592
            GRAIFASGSPFDPVTLP G+TL+PGQGNNSYVFPGVALGVVACGLRHI DK+ LTTAEV+
Sbjct: 7    GRAIFASGSPFDPVTLPDGRTLFPGQGNNSYVFPGVALGVVACGLRHIDDKVFLTTAEVL 66


  Database: RefSeqMP
    Posted date:  Aug 2, 2006 12:58 AM
  Number of letters in database: 21,768,885
  Number of sequences in database:  45,328
  
Lambda     K      H
   0.318    0.134    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 91,437,922
Number of Sequences: 45328
Number of extensions: 2292341
Number of successful extensions: 6519
Number of sequences better than 1.0e-05: 8
Number of HSP's better than  0.0 without gapping: 5571
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 6504
length of database: 21,768,885
effective HSP length: 111
effective length of database: 16,737,477
effective search space used: 10460923125
frameshift window, decay const: 40,  0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)